Kontorlandskap, forskning

Forskning i CERG

CERG har mer enn 50 ansatte, og forskningsaktiviteten i gruppa er høy. På denne sida kan du lese mer om de nyeste forskningsresultatene våre, om pågående forskningsprosjekter, og kanskje finne en studie som det passer å delta i for deg eller noen du kjenner.


CERG-laboratorium, studier

Generasjon 100-studien og HUNT4 Kondisprosjektet er blant de største pågående forskningsprosjektene i gruppa, i tillegg til multisenterstudier om treningseffekter ved hjertesvikt og metabolsk syndrom. 

CERG har høy forskningsaktivitet, og på denne sida kan du lese mer om både større og mindre forskningsprosjekter i gruppa.

Delta i vår forskning

Forskningsdeltaker løper på tredemølle

CERG gjennomfører mange studier, og vi har av og til behov for deltakere. Kanskje trenger du et lite puff for å komme i gang med regelmessig trening?

Klikk her hvis du kan tenke deg å delta i et av forskningsprosjektene våre.

Liste over vitenskapelige publikasjoner


Dalen, T., Lorås, H., Hjelde, G. H., Kjøsnes, T. N., & Wisløff, U. (2019). Accelerations – a new approach to quantify physical performance decline in male elite soccer?European Journal of Sport Science, 1-9.

Rasch-Halvorsen, Ø., Hassel, E., Langhammer, A., Brumpton, B. M., & Steinshamn, S. (2019). The association between dynamic lung volume and peak oxygen uptake in a healthy general population: the HUNT studyBMC Pulmonary Medicine, 19(1), 2.


Souza, R. W., Alves, C. R., Medeiros, A., Rolim, N., Silva, G. J., Moreira, J. B., Alves, M. N., Wohlwend, M., Gebriel, M., Hagen, L., Sharma, A., Koch, L. G., Britton, S. L., Slupphaug, G., Wisløff, U., & Brum, P. C. (2018). Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacityScientific reports, 8(1), 17772.

Shi, M., Ellingsen, Ø., Bathen, T. F., Høydal, M. A., Koch, L. G., Britton, S. L., Wisløff, U., Stølen, T., & Esmaeili, M. (2018). Skeletal muscle metabolism in rats with low and high intrinsic aerobic capacity: Effect of aging and exercise trainingPLOS ONE, 13(12), e0208703.

Letnes, J. M., Dalen, H., Vesterbekkmo, E. K., Wisløff, U., & Nes, B. M. (2018). Peak oxygen uptake and incident coronary heart disease in a healthy population: the HUNT Fitness Study European Heart Journal, ehy708

Berglund, I. J., Sørås, S. E., Relling, B. E., Lundgren, K. M., Kiel, I. A., & Moholdt, T. (2018). The relationship between maximum heart rate in a cardiorespiratory fitness test and in a maximum heart rate testJournal of Science and Medicine in Sport.

Ozemek, C., Laddu, D. R., Lavie, C. J., Claeys, H., Kaminsky, L. A., Ross, R., Wisløff, U., Arena, R., & Blair, S. N. (2018). An Update on the Role of Cardiorespiratory Fitness, Structured Exercise and Lifestyle Physical Activity in Preventing Cardiovascular Disease and Health RiskProgress in Cardiovascular Diseases.

Gunnes, M., Langhammer, B., Aamot, I. L., Lydersen, S., Ihle-Hansen, H., Indredavik, B., Kristine H. Reneflot, Schroeter, W., & Askim, T. (2018). Adherence to a Long-Term Physical Activity and Exercise Program After Stroke Applied in a Randomized Controlled TrialPhysical therapy.

Thomsen, R. S., Nilsen, T. I. L., Haugeberg, G., Bye, A., Kavanaugh, A., & Hoff, M. (2018). Effect of high-intensity interval training on cardiovascular disease risk factors and body composition in psoriatic arthritis: a randomised controlled trialRMD Open, 4(2), e000729.

Zotcheva, E., Bergh, S., Selbæk, G., Krokstad, S., Håberg, A. K., Strand, B. H., & Ernstsen, L. (2018). Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT StudyJournal of Alzheimer's Disease, (Preprint), 1-9.

Tucker, W. J., Beaudry, R. I., Liang, Y., Clark, A. M., Tomczak, C. R., Nelson, M. D., Ellingsen, Ø., & Haykowsky, M. J. (2018). Meta-analysis of exercise training on left ventricular ejection fraction in heart failure with reduced ejection fraction: a 10–year update. Progress in cardiovascular diseases.

Kieffer, S. K., Croci, I., Wisløff, U., & Nauman, J. (2018). Temporal Changes in a Novel Metric of Physical Activity Tracking (Personal Activity Intelligence) and Mortality: The HUNT Study, NorwayProgress in Cardiovascular Diseases.

Reitlo, L. S., Sandbakk, S. B., Viken, H., Aspvik, N. P., Ingebrigtsen, J. E., Tan, X., Wisløff, U., & Stensvold, D. (2018). Exercise patterns in older adults instructed to follow moderate-or high-intensity exercise protocol–the generation 100 studyBMC Geriatrics, 18(1), 208.

Bowen, T. S., Herz, C., Rolim, N. P., Berre, A. M. O., Halle, M., Kricke, A., Linke, A., da Silva, G. J., Wisløff, U., & Adams, V. (2018). Effects of endurance training on detrimental structural, cellular, and functional alterations in skeletal muscles of heart failure with preserved ejection fractionJournal of cardiac failure, 24(9), 603-613.

Kieffer, S. K., Zisko, N., Coombes, J. S., Nauman, J., & Wisløff, U. (2018) Personal Activity Intelligence and Mortality in Patients with Cardiovacular Disease: The HUNT Study. Mayo Clinic Proceedings, 92(5), 1191-1201

Bozi, L. H., Takano, A. P., Campos, J. C., Rolim, N., Dourado, P. M., Voltarelli, V. A., Wisløff, U., Ferreira, J. C. B., Barreto-Chaves, M. L. M., & Brum, P. C. (2018). Endoplasmic reticulum stress impairs cardiomyocyte contractility through JNK-dependent upregulation of BNIP3International Journal of Cardiology.

Myrstad, M., Malmo, V., Ulimoen, S. R., Tveit, A., & Loennechen, J. P. (2018). Exercise in individuals with atrial fibrillationClinical Research in Cardiology, 1-8.

Viken, H., Reitlo, L. S., Zisko, N., Nauman, J., Aspvik, N. P., Ingebrigtsen, J. E., Wisløff, D., & Stensvold, D. (2018). Predictors of Dropout in Exercise Trials in Older AdultsMedicine and science in sports and exercise.

Bjørnland, T., Bye, A., Ryeng, E., Wisløff, U., & Langaas, M. (2018). Powerful extreme phenotype sampling designs and score tests for genetic association studiesStatistics in medicine.

Aspvik, N. P., Viken, H., Ingebrigtsen, J. E., Zisko, N., Mehus, I., Wisløff, U., & Stensvold, D. (2018). Do weather changes influence physical activity level among older adults?–The Generation 100 studyPloS one, 13(7), e0199463.

Garnvik, L. E., Malmo, V., Janzsky, I., Wisløff, U., Loennechen, J. P., & Nes, B. M. (2018). Physical activity modifies the risk of atrial fibrillation in obese individuals: The HUNT3 study. European Journal of Preventive Cardiology. 2047487318784365

Nyrnes, S. A., Garnæs, K. K., Salvesen, Ø., Timilsina, A. S., Moholdt, T., & Ingul, C. B. (2018). Cardiac function in newborns of obese women and the effect of exercise during pregnancy. A randomized controlled trialPloS one 13(6): e0197334

Zotcheva, E., Selbæk, G., Bjertness, E., Ernstsen, L., & Strand, B. H. (2018). Leisure-time physical activity is associated with reduced risk of dementia-related mortality in adults with and without psychological distress: The Cohort of NorwayFrontiers in Aging Neuroscience, 10, 151.

Aamot, I. L., & Rognmo, Ø. (2018) Exercise therapy in intermittent claudication. E-Journal of Cardiology Practice

Carlsen, T., Salvesen, Ø., Sui, X., Lavie, C. J., Blair, S. N., Wisløff, U., & Ernstsen, L. (2018). Long-term Changes in Depressive Symptoms and Estimated Cardiorespiratory Fitness and Risk of All-Cause Mortality: The Nord-Trøndelag Health Study. Mayo Clinic Proceedings.

Tjønna, A. E., Ramos, J. S., Pressler, A., Halle, M., Jungbluth, K., Ermacora, E., Salvesen, Ø., Rodrigues, J., Bueno jr., C. R., Munk, P. S., Coombes, J., & Wisløff, U. (2018). EX-MET study: exercise in prevention on of metabolic syndrome–a randomized multicenter trial: rational and designBMC public health, 18(1), 437.

Moholdt, T., Lavie, C. J., & Nauman, J. (2018). Sustained Physical Activity, Not Weight Loss, Associated With Improved Survival in Coronary Heart DiseaseJournal of the American College of Cardiology, 71(10), 1094-1101.

Neto, M. G., Durães, A. R., Conceição, L. S. R., Saquetto, M. B., Ellingsen, Ø., & Carvalho, V. O. (2018). High intensity interval training versus moderate intensity continuous training on exercise capacity and quality of life in patients with heart failure with reduced ejection fraction: A systematic review and meta-analysisInternational Journal of Cardiology.

Dias, K. A., Ingul, C. B., Tjønna, A. E., Keating, S. E., Gomersall, S. R., Follestad, T., Hosseini, M. S., Hollekim-Strand, S. M., Ro, T. B., Haram, M., & Huuse, E. M., Davies, P. S. W., Cain, P. A., Leong, G. M., & Coombes, J. S. (2017). Effect of High-Intensity Interval Training on Fitness, Fat Mass and Cardiometabolic Biomarkers in Children with Obesity: A Randomised Controlled TrialSports Medicine, 1-14.

Malmo, V., Kelly, A., Stolen, T., Garten, K. S., Rolim, N., Wisløff, U., Smith, G., & Loennechen, J. P. (2018). Aerobic interval training prevents age-dependent vulnerability to atrial fibrillation in rodentsFrontiers in Physiology, 9, 206.

Ingul, C. B. (2018). Low volume, high intensity: Time-efficient exercise for the treatment of hypertensionEuropean Journal of Preventive Cardiology, 2047487318760040.

Smenes, B. T., Bækkerud, F. H., Slagsvold, K. H., Hassel, E., Wohlwend, M., Pinho, M., Høydal, M., Wisløff, U., Rognmo, Ø., & Wahba, A. (2018). Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trialInteractive cardiovascular and thoracic surgery.

Ingul, C. B., Dias, K. A., Tjonna, A. E., Follestad, T., Hosseini, M. S., Timilsina, A. S., Hollekim-Strand, S. M., Ro, T. B., Davies, P. S. W., Leong, G. M., & Coombes, J. S. (2018). Effect of High Intensity Interval Training on Cardiac Function in Children with Obesity: a Randomised Controlled TrialProgress in Cardiovascular Diseases.

Høydal, M. A., Kirkeby‐Garstad, I., Karevold, A., Wiseth, R., Haaverstad, R., Wahba, A., Stølen, T., L. Contu, R., Condorelli, G., Ellingsen, Ø., Smith, G. L., Kemi, O. J., & Wisløff, U. (2018). Human cardiomyocyte calcium handling and transverse tubules in mid‐stage of post‐myocardial‐infarction heart failureESC heart failure.


Williams, C. J., Williams, M. G., Eynon, N., Ashton, K. J., Little, J. P., Wisloff, U., & Coombes, J. S. (2017). Genes to predict VO 2max trainability: a systematic reviewBMC genomics, 18(8), 831.

Ellingsen, Ø. (2018). A flying start? Early interval training in heart failure rehabilitationEuropean Journal of Preventive Cardiology, 25(1), 7-8

Stensvold, D., Sandbakk, S. B., Viken, H., Zisko, N., Reitlo, L. S., Nauman, J., Gaustad, S. E., Hassel, E., Moufack, M., Brønstad, E., Aspvik, N. P., Malmo, V., Steinshamn, S. L., Støylen, A., Anderssen, S. A., Helbostad, J. L., Rognmo, Ø, & Wisløff, U. (2017). Cardiorespiratory Reference Data in Older Adults: The Generation 100 StudyMedicine and science in sports and exercise, 49(11), 2206.

Bowen, T. S., Brauer, D., Rolim, N. P., Bækkerud, F. H., Kricke, A., Berre, A. M. O., Fischer, T., Linke, A., da Silva G. J., Wisløff, U., & Adams, V. (2017). Exercise Training Reveals Inflexibility of the Diaphragm in an Animal Model of Patients With Obesity‐Driven Heart Failure With a Preserved Ejection FractionJournal of the American Heart Association, 6(10), e006416.

Mallard, A. R., Hollekim-Strand, S. M., Coombes, J. S., & Ingul, C. B. (2017). Exercise intensity, redox homeostasis and inflammation in type 2 diabetes mellitusJournal of science and medicine in sport, 20(10), 893-898.

Zaglia, T., Ceriotti, P., Campo, A., Borile, G., Armani, A., Carullo, P., Prando, V., Coppini, R., Vida, V., Stølen, T., Wisløff, U., Cerbai, E., Stellin, G., Faggian, G., De Stefani, D., Sandri, M., Rizzuto, R., Di Lisa, F., Pozzan, T., Catalucci, D., & Mongillo, M. (2017). Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophyProceedings of the National Academy of Sciences, 201708772.

Wisloff, U., & Lavie, C. J. (2017). Taking Physical Activity, Exercise, and Fitness to a Higher Level. Progress in cardiovascular diseases, 60(1), 1.

Wisløff, U., Lavie, C. J., & Rognmo, Ø. (2017). Letter by Wisløff et al Regarding Article,“High-Intensity Interval Training in Patients With Heart Failure With Reduced Ejection Fraction”Circulation, 136(6), 607-608.

Leinan, I. M., Aamot, I. L., Støylen, A., Karlsen, T., & Wisløff, U. (2015). Upper arm venous compliance and fitness in stable coronary artery disease patients and healthy controlsClinical physiology and functional imaging.

Martins C, Aschehoug I, Ludviksen M, Holst J, Finlayson G, Wisloff U, Morgan L, King N, Kulseng B. (2017). High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese. Medicine & Science in Sports & Exercise 49(9):1851-1858

D'Souza, A., Pearman, C. M., Wang, Y., Nakao, S., Logantha, S. J. R., Cox, C., Bennett, H., Zhang., Y., Johnsen, A. B., Linscheid, N., Poulsen, P. C., Elliott, J., Coulson, J., McPhee, J., Robertson, A., da Costa Martins, P. A., Kitmitto, A., Wisløff, U., Cartwright, E. J., Monfredi, O., Lundby, A., Dobrzynski, H., Ocaendy, D., Morris, G. M., & Boyett, M. R. (2017). Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus BradycardiaCirculation research, CIRCRESAHA-117.

Dias, K. A., Masterson, C. E., Wallen, M. P., Tjonna, A. E., Hosseini, M. S., Davies, P. S., Cain, P. A., Leong, G. M., Arena, R., Ingul, C. B., & Coombes, J. S. (2017). Assessment of the 5-Minute Oxygen Uptake Efficiency Slope in Children With ObesityPediatric exercise science, 29(3), 350-360.

Dias, K. A., Spence, A. L., Sarma, S., Oxborough, D., Timilsina, A. S., Davies, P. S., Cain, P. A., Leong, G. M., Ingul, C. B., & Coombes, J. S. (2017). Left ventricular morphology and function in adolescents: Relations to fitness and fatnessInternational journal of cardiology, 240, 313-319.

Silva, G. J., Bye, A., el Azzouzi, H., & Wisløff, U. (2017). MicroRNAs as important regulators of exercise adaptationProgress in cardiovascular diseases, 60(1), 130-151.

Sandbakk, S. B., Nauman, J., Lavie, C. J., Wisløff, U., & Stensvold, D. (2017). Combined Association of Cardiorespiratory Fitness and Body Fatness With Cardiometabolic Risk Factors in Older Norwegian Adults: The Generation 100 StudyMayo Clinic Proceedings: Innovations, Quality & Outcomes, 1(1), 67-77.

Karlsen, T., Aamot, I. L., Haykowsky, M., & Rognmo, Ø. (2017). High Intensity Interval Training for Maximizing Health OutcomesProgress in Cardiovascular Diseases.

Zisko, N., Skjerve, K. N., Tari, A. R., Sandbakk, S. B., Wisloff, U., Nes, B. M., & Nauman, J. (2017). Personal Activity Intelligence (PAI), Sedentary Behavior and Cardiovascular Risk Factor Clustering-The HUNT Study. Progress in Cardiovascular Diseases.

Nauman, J., Tauschek, L. C., Kaminsky, L. A., Nes, B. M., & Wisløff, U. (2017). Global fitness levels: findings from a Web-based surveillance reportProgress in Cardiovascular Diseases.

Schaardenburgh, M., Wohlwend, M., Rognmo, Ø., & Mattsson, E. J. (2017). Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial functionJournal of translational medicine, 15(1), 130.

Morland, C., Andersson, K. A., Haugen, Ø. P., Hadzic, A., Kleppa, L., Gille, A., Rinholm, J. E., Palibrk, V., Diget, E. H., Kennedy, L. H., Stølen, T., Hennestad, E., Moldestad, O., Cai, Y., Puchades, M., Offermanns, S., Vervaeke, K., Bjørås, M., Wisløff, U., Storm-Mathisen, J., & Bergersen, L. H., (2017). Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1Nature Communications, 8.

Zisko, N., Nauman, J., Sandbakk, S. B., Aspvik, N. P., Salvesen, Ø., Carlsen, T., Viken, H., Ingebrigtsen, J. E., Wisløff, U., & Stensvold, D. (2017). Absolute and relative accelerometer thresholds for determining the association between physical activity and metabolic syndrome in the older adults: The Generation-100 studyBMC geriatrics, 17(1), 109.

Karlsen, T., Nauman, J., Dalen, H., Langhammer, A., & Wisløff, U. (2017, May). The Combined Association of Skeletal Muscle Strength and Physical Activity on Mortality in Older Women: The HUNT2 Study. In Mayo Clinic Proceedings (Vol. 92, No. 5, pp. 710-718). Elsevier.

Bowen, T. S., Aakerøy, L., Eisenkolb, S., Kunth, P., Bakkerud, F., Wohlwend, M., Berre, A. M. O., Fischer, T., Wisløff, U., Schuler, G., Steinshamn, S., Adams, V, & Brønstad, E., (2017). Exercise Training Reverses Extrapulmonary Impairments in Smoke-exposed MiceMedicine and science in sports and exercise, 49(5), 879-887.

Østhus, I. B. Ø., Lydersen, S., Dalen, H., Nauman, J., & Wisløff, U. (2017). Association of Telomere Length With Myocardial Infarction: A Prospective Cohort From the Population Based HUNT 2 StudyProgress in Cardiovascular Diseases.

Van Schaardenburgh, M., Wohlwend, M., Rognmo, Ø., & Mattsson, E. (2017). Calf raise exercise increases walking performance in patients with intermittent claudication. Journal of vascular surgery, 65(5), 1473-1482.

Hassel, E., Stensvold, D., Halvorsen, T., Wisløff, U., Langhammer, A., & Steinshamn, S. (2017). Lung function parameters improve prediction of VO2peak in an elderly population: The Generation 100 studyPloS one, 12(3), e0174058.

Ljones, K., Ness, H. O., Solvang-Garten, K., Gaustad, S. E., & Høydal, M. A. (2017). Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley ratsPloS one, 12(3), e0173449.

Nes, B. M., Gutvik, C. R., Lavie, C. J., Nauman, J., & Wisløff, U. (2017). Personalized activity intelligence (PAI) for prevention of cardiovascular disease and promotion of physical activityThe American journal of medicine, 130(3), 328-336.

Ellingsen, Ø., Halle, M., Conraads, V., Støylen, A., Dalen, H., Delagardelle, C.,  Larsen, A-I., Hole, T., Mezzqani, A., van Craenenbroeck E. M., Videm, V., Beckers, P. J., Christie, J. W., Winzer, E. B., Mangne, N., Woitek, F., Höllriegel, R., Pressler, A. P., Monk-Hansen, T., Snoer, M., Feiereisen, P., Valborgland, T., Kjekshus, J. K., Hambrecht, R., Gielen, S., Karlsen, T., Prescott, E. B. & Linke, A. (2017). High-Intensity Interval Training in Patients With Heart Failure With Reduced Ejection FractionCirculation, 135(9), 839-849.