Bakgrunn og aktiviteter

Research focus: TGF-β superfamily signaling in multiple myeloma

Our research is focused on understanding the role of transforming growth factor (TGF)-ß superfamily signaling pathways in multiple myeloma. This includes ligands such as TGF-ß, activins, BMPs and GDFs. There is extensive redundancy in this superfamily of ligands and receptors, and the effects of a given molecule will always depend on the context. Activation of the SMAD1/5 transcription factors by TGF-ß superfamily ligands induces apoptosis in myeloma cells by downregulating the oncogene c-MYC. We reviewed the role of BMP signaling in myeloma cell survival in 2014 (Figure 1). Potentiaion of SMAD1/5 activity represents therefore a possible treatment option for myeloma patients. We are also interested in the role of TGF-ß signaling in the context of the tumor microenvironment, particularly in relation to angiogenesis and dissemination. For this part we collaborate with the Bjørkøy group.

We welcome students that want to study regulation of signaling in the TGF-ß superfamily.

 

Figure 1. BMP signal transduction. (Reprinted from CGFR, Vol 25/Issue 3, Toril Holien and Anders Sundan, The role of bone morphogenetic proteins in myeloma cell survival, Pages No. 343-350, Copyright 2014, with permission from Elsevier)

 

People in the lab

Post doctor: Oddrun Elise Olsen
- Interview, "First person" Journal of Cell Science, 2018.
PhD student (Bjørkøy group, cosupervised): Camilla Wolowczyk
Medical student (Medical Students' Research Programme): Ingrid Quist-Løkken
Master students:
Molecular medicine: Aliaksandr Maisiuk
Biotechnology (cosupervised): Jenny Malm Rasmussen

Former students
PhD (2012-2017): Oddrun Elise Olsen

Master level:
Pharmacy (2018/19): Martin Haugrud Kastnes, Nerissa Rae Booc
Pharmacy (2017/18): Thi Le, Fartun Hussein Ali
Molecular Medicine (2016/17): Samah Elsaadi, Fekadu Alemu Atire, Vilde Yuli Stenberg
Biotechnology (2013/15): Anette Skjærvik
Cell biology (2012/14): Kine Husteli Kristiansen
Biotechnology (2011/12): Oddrun Elise Olsen
Erasmus trainee students: Alexander Stockhammer (2018), Marie-Thérèse Henke (2017), Meenu Sankar (2015/16), Sarah Nevens (2013/14)

 

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