Morten Beck Rye
Om
Jeg driver translasjonell forskning innen beregningsbiologi med fokus på integrasjon av storskaladata fra genekspresjon, metabolisme, epigenetikk og genregulering for å forbedre diagnostikk og behandlingsvalg for pasienter med prostatakreft. Dette gjøres i et forskningssamarbeid mellom BiGR og MR-Senteret på NTNU og Urologisk institutt ved St.Olavs hospital. Gjennom vår forsking prøver vi å finne ut hva som skiller aggressiv fra ufarlig prostatakreft på molekylært nivå gjennom integrasjon av data generert fra ulike høykapasitetsteknologier.
Det har i de senere år vært økt fokus på menns helse i kampanjer og offentlige debatter, noe som har ført en økning i antall menn som testes for prostatakreft. En utfordring inne prostatakreftdiagnostikk er å kunne skille de kreftformene som er aggressive og livstruende, fra se som er ufarlige. Dette gjøres i dag ved å vurdere innsamlede kliniske data fra MR-bilder, blodprøver og vevsprøver fra prostata. På grunn av begrensinger i klassifiseringssystemet, har overbehandling av ufarlig prostatakreft blitt en økende belastning for både pasienter og helsesystemet. I tillegg kommer det at dagens klassifisering i enkelt tilfeller også mislykkes med å detektere aggressive kreftformer. Målet for vår forskning er derfor å forbedre klassifiseringen av aggressiv og ufarlig prostatakreft, både ved første diagnose og for pasienter under aktiv overvåkning av sykdommen.
Vi utvikler for tiden en robust klassifikator for aggressiv prostatakreft baser på molekylære data fra vevsbiopsier, som er invasiv i prostata. Vår visjon derimot, er at aggressiv prostatakreft skal kunne detekteres kun ved minimalt invasive metoder (f.eks blodprøver) eller ikke-invasive metoder som MR-avbilding. For å oppnå dette har vi valgt å fokusere vår forskning på detaljert storskala analyse av frosset vev donert av pasienter med prostatkreft. Vi analysere prøvene molekylært med nye avanserte målemetoder for å få en forståelse av hvordan vevsstrukturer, molekylære sammensetninger og bildesegmenter kan knyttes mot hverandre. Dette er hovedtema i ProstOmics, et pågående samarbeidsprosjekt hvor Gruppe for bioinformatikk bidrar med beregningsbaserte analyser.
Forskningsaktivitet og retninger
Utvikling og validering av en robust geneskpresjonssignatur som kan skille aggressiv og ufarlig prostatakreft fra kliniske pasientprøver
Integrasjon av data fra ProstOmics med store mengder fritt tilgjengelige data for å knytte molekylære signaturesr med vev og MR-bilde-strukturer. Dette for å forbedre ikke-invasiv klassifisering av aggressiv prostatakreft
Undersøke potensialet for epigenetiske markører for deteksjon av aggressiv prostatakreft i blod, urin og sekret fra prostata.
I tillegg er jeg involvert i kjernefasiliteten for bioinformatikk (BioCore) og tilsvarende tjenester for bioinformatikk gjennom Elixir, der jeg assisterer andre forskere med bioinformatikk-analyser i ulike prosjekter. Jeg er også ansvarlig for et årlig kurs i sekvenseringsanalyse (arrangert annethvert år gjennom NORBIS).
Publikasjoner
2025
-
Wess, Maximilian;
Andersen, Maria Karoline;
Midtbust, Elise;
Guillem, Juan Carlos Cabellos;
Viset, Trond;
Størkersen, Øystein.
(2025)
Spatial integration of multi-omics data from serial sections using the novel Multi-Omics Imaging Integration Toolset.
GigaScience
Vitenskapelig artikkel
2024
-
Wess, Maximilian;
Andersen, Maria Karoline;
Midtbust, Elise;
Guillem, Juan Carlos Cabellos;
Viset, Trond;
Størkersen, Øystein.
(2024)
Spatial Integration of Multi-Omics Data using the novel Multi-Omics Imaging Integration Toolset.
bioRxiv
Vitenskapelig artikkel
-
Bergum, Olaug Elisabeth Torheim;
Singleton, Amanda Holstad;
Røst, Lisa Marie Ivarsdatter;
Bodein, Antoine;
Scott-Boyer, Marie-Pier;
Rye, Morten Beck.
(2024)
SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated.
Frontiers in Microbiology
Vitenskapelig artikkel
-
Behsen, Alenka Djarmila;
Holien, Toril;
Micci, Francesca;
Rye, Morten Beck;
Rasmussen, Jenny Malm;
Andersen, Kristin.
(2024)
Cell surface marker heterogeneity in human myeloma cell lines for modeling of disease and therapy.
Scientific Reports
Vitenskapelig artikkel
-
Andersen, Maria K.;
Krossa, Sebastian;
Midtbust, Elise;
Pedersen, Christine Aaserød;
Wess, Maximilian;
Høiem, Therese Stork.
(2024)
Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer.
Communications Biology
Vitenskapelig artikkel
-
Kiviaho, Antti;
Eerola, Sini K.;
Kallio, Heini M.L.;
Andersen, Maria K.;
Hoikka, Miina;
Salonen, Iida.
(2024)
Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer.
Nature Communications
Vitenskapelig artikkel
2023
-
Andersen, Maria Karoline;
Krossa, Sebastian;
Midtbust, Elise;
Pedersen, Christine Aaserød;
Wess, Maximilian;
Høiem, Therese Stork.
(2023)
Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer.
Research Square
Vitenskapelig artikkel
2022
-
Andersen, Maria Karoline;
Krossa, Sebastian;
Midtbust, Elise;
Viset, Trond;
Størkersen, Øystein;
Giskeødegård, Guro F..
(2022)
Multiomics spatial mapping of lipid metabolism in prostate cancer.
European Urology
Sammendrag/abstract
-
Krossa, Sebastian;
Andersen, Maria Karoline;
Midtbust, Elise;
Viset, Trond;
Størkersen, Øystein;
Giskeødegård, Guro.
(2022)
Inflammatory chemokines upregulated in the tumor microenvironment of prostate cancer patients experiencing relapse after radical prostatectomy.
European Urology
Sammendrag/abstract
-
Pedersen, Christine Aaserød;
Cao, Maria Dung;
Fleischer, Thomas;
Rye, Morten Beck;
Knappskog, Stian;
Eikesdal, Hans Petter.
(2022)
DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival.
Breast Cancer Research
Vitenskapelig artikkel
-
Grapotte, Mathys;
Saraswat, Manu;
Bessière, Chloé;
Menichelli, Christophe;
Ramilowski, Jordan A.;
Severin, Jessica.
(2022)
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7).
Nature Communications
Errata
-
Rise, Kjersti;
Tessem, May-Britt;
Drabløs, Finn;
Rye, Morten Beck.
(2022)
FunHoP analysis reveals upregulation of mitochondrial genes in prostate cancer.
PLOS ONE
Vitenskapelig artikkel
-
Misund, Kristine;
Hofste op Bruinink, Davine;
Coward, Eivind;
Hoogenboezem, Remco M.;
Rustad, Even Holth;
Sanders, Mathijs A..
(2022)
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence.
Leukemia
Vitenskapelig artikkel
-
Rye, Morten Beck;
Krossa, Sebastian;
Hall, Martina;
van Mourik, Casper;
Bathen, Tone Frost;
Drabløs, Finn.
(2022)
The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems.
iScience
Vitenskapelig artikkel
-
Emdal, Elisabeth Fritzke;
Ottestad, Anine Larsen;
Vågbø, Cathrine Broberg;
Skarpeteig, Veronica ;
Rye, Morten Beck.
(2022)
Prøv deg som en DNA-detektiv.
Forskningstorget 2022
Annen presentasjon
-
Hansen, Ailin Falkmo;
Høiem, Therese Stork;
Selnæs, Kirsten Margrete;
Bofin, Anna M.;
Størkersen, Øystein;
Bertilsson, Helena.
(2022)
Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy.
NMR in Biomedicine
Vitenskapelig artikkel
2021
-
Vandsemb, Esten;
Rye, Morten Beck;
Steiro, Ida Johnsen;
Elsaadi, Samah;
Rø, Torstein Baade;
Slørdahl, Tobias Schmidt.
(2021)
PRL-3 induces a positive signaling circuit between glycolysis and activation of STAT1/2.
The FEBS Journal
Vitenskapelig artikkel
-
Rise, Kjersti;
Tessem, May-Britt;
Drabløs, Finn;
Rye, Morten Beck.
(2021)
FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks.
Genomics, Proteomics & Bioinformatics (GPB)
Vitenskapelig artikkel
-
Andersen, Maria Karoline;
Høiem, Therese Stork;
Claes, Britt S.R.;
Balluff, Benjamin;
Marta, Martin-Lorenzo;
Richardsen, Elin.
(2021)
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI.
Cancer & Metabolism
Vitenskapelig artikkel
2020
-
Rauluseviciute, Ieva;
Drabløs, Finn;
Rye, Morten Beck.
(2020)
DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation.
BMC Medical Genomics
Vitenskapelig artikkel
-
Jalili, Mahsa;
Gerdol, Marco;
Greco, S.;
Pallavicini, Alberto;
Buonocore, Francesco;
Scapigliati, Giuseppe.
(2020)
Differential Effects of Dietary Supplementation of Krill Meal, Soybean Meal, Butyrate, and Bactocell® on the Gene Expression of Atlantic Salmon Head Kidney.
International Journal of Molecular Sciences
Vitenskapelig artikkel
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances
Vitenskapelig artikkel
2019
-
Grinde, Maria Tunset;
Hilmarsdòttir, Bylgja;
Tunset, Hanna Maja;
Henriksen, Ida Marie;
Kim, Jana;
Haugen, Mads Haugland.
(2019)
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer .
Breast Cancer Research
Vitenskapelig artikkel
-
Vardaxis, Ioannis;
Drabløs, Finn;
Rye, Morten Beck;
Lindqvist, Bo Henry.
(2019)
MACPET: model-based analysis for ChIA-PET.
Biostatistics
Vitenskapelig artikkel
-
Reuluseviciute, Ieva;
Drabløs, Finn;
Rye, Morten Beck.
(2019)
DNA methylation data by sequencing: experimental approaches and recommendations for tools and pipelines for data analysis.
Clinical Epigenetics
Vitenskapelig oversiktsartikkel/review
2018
-
Tekle, Kidane M;
Gundersen, Sveinung;
Klepper, Kjetil;
Bongo, Lars Ailo;
Raknes, Inge Alexander;
Li, Xiaxi.
(2018)
Norwegian e-Infrastructure for Life Sciences (NeLS).
F1000 Research
Vitenskapelig artikkel
-
Andersen, Maria Karoline;
Rise, Kjersti;
Giskeødegård, Guro F.;
Richardsen, Elin;
Bertilsson, Helena;
Størkersen, Øystein.
(2018)
Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma.
Scientific Reports
Vitenskapelig artikkel
-
Rye, Morten Beck;
Bertilsson, Helena;
Andersen, Maria Karoline;
Rise, Kjersti;
Bathen, Tone Frost;
Drabløs, Finn.
(2018)
Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized.
BMC Cancer
Vitenskapelig artikkel
-
Søgaard, Caroline Danielsen;
Moestue, Siver Andreas;
Rye, Morten Beck;
Kim, Jana;
Nepal, Anala;
Liabakk, Nina-Beate.
(2018)
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
OncoTarget
Vitenskapelig artikkel
2017
-
Sandsmark, Elise;
Andersen, Maria Karoline;
Bofin, Anna M.;
Bertilsson, Helena;
Drabløs, Finn;
Bathen, Tone Frost.
(2017)
SFRP4 gene expression is increased in aggressive prostate cancer.
Scientific Reports
Vitenskapelig artikkel
2016
-
Hansen, Ailin Falkmo;
Sandsmark, Elise;
Rye, Morten Beck;
Wright, Alan J;
Bertilsson, Helena;
Richardsen, Elin.
(2016)
Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer.
OncoTarget
Vitenskapelig artikkel
-
Sandsmark, Elise;
Hansen, Ailin Falkmo;
Selnæs, Kirsten Margrete;
Bertilsson, Helena;
Bofin, Anna M.;
Wright, Alan J..
(2016)
A novel non-canonical Wnt signature for prostate cancer aggressiveness.
OncoTarget
Vitenskapelig artikkel
-
Vandsemb, Esten Nymoen;
Bertilsson, Helena;
Abdollahi, Pegah;
Størkersen, Øystein;
Våtsveen, Thea Kristin;
Rye, Morten Beck.
(2016)
Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Tessem, May-Britt;
Bertilsson, Helena;
Angelsen, Anders;
Bathen, Tone Frost;
Drabløs, Finn Sverre;
Rye, Morten Beck.
(2016)
A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer.
PLOS ONE
Vitenskapelig artikkel
2015
-
Hurst, Laurence D.;
Ghanbarian, Avazeh T.;
Forrest, Alistair R.R.;
Huminiecki, Lukasz;
Haberle, Vanja;
Drabløs, Finn Sverre.
(2015)
The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome.
PLoS Biology
Vitenskapelig artikkel
-
Rydbeck, Halfdan;
Sandve, Geir Kjetil F.;
Ferkingstad, Egil;
Simovski, Boris;
Rye, Morten Beck;
Hovig, Johannes Eivind.
(2015)
ClusTrack: Feature extraction and similarity measures for clustering of genome-wide data sets.
PLOS ONE
Vitenskapelig artikkel
2014
-
Tessem, May-Britt;
Rye, Morten Beck.
(2014)
Early markers of a potentially dangerous type of prostate cancer.
Nettsider (opplysningsmateriale)
-
Forest, Alistair R.R.;
Kawaji, Hideya;
Rehli, Michael;
Baillie, John Kenneth;
de Hoon, Michiel;
Haberle, Vanja.
(2014)
A promoter-level mammalian expression atlas.
Nature
Vitenskapelig artikkel
-
Rye, Morten Beck;
Bertilsson, Helena;
Drabløs, Finn;
Angelsen, Anders;
Bathen, Tone Frost;
Tessem, May-Britt.
(2014)
Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer.
BMC Medical Genomics
Vitenskapelig artikkel
-
Rye, Morten Beck;
Sandve, Geir Kjetil F.;
Daub, Carsten O;
Kawaji, H;
Carninci, P;
Forrest, A.
(2014)
Chromatin states reveal functional associations for globally defined transcription start sites in four human cell lines.
BMC Genomics
Vitenskapelig artikkel
2013
-
Sandve, Geir Kjetil;
Gundersen, Sveinung;
Johansen, Morten;
Glad, Ingrid Kristine;
Gunathasan, Krishanthi;
Holden, Lars.
(2013)
The Genomic HyperBrowser: an analysis web server for genome-scale data.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Hofsli, Eva;
Sjursen, Wenche;
Prestvik, Wenche S;
Johansen, Jostein;
Rye, Morten Beck;
Tranø, Gerd.
(2013)
Identification of serum microRNA profiles in colon cancer.
British Journal of Cancer
Vitenskapelig artikkel
2012
-
Rye, Morten Beck;
Færgestad, Ellen Mosleth.
(2012)
Preprocessing of electrophoretic images in 2-DE analysis.
Chemometrics and Intelligent Laboratory Systems
Vitenskapelig artikkel
-
Kornacker, K;
Rye, Morten Beck;
Håndstad, Tony;
Drabløs, Finn.
(2012)
The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding.
BMC Bioinformatics
Vitenskapelig artikkel
-
Håndstad, Tony;
Rye, Morten Beck;
Mocnik, Rok;
Drabløs, Finn;
Sætrom, Pål.
(2012)
Cell-type specificity of ChIP-predicted transcription factor binding sites.
BMC Genomics
Vitenskapelig artikkel
2011
-
Rye, Morten Beck;
Sætrom, Pål;
Drabløs, Finn.
(2011)
A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Sun, Cheng;
Fiksdal, Liv;
Hanssen-Bauer, Audun;
Rye, Morten Beck;
Leiknes, TorOve.
(2011)
Characterization of membrane biofouling at different operating conditions (flux) in drinking water treatment using confocal laser scanning microscopy (CLSM) and image analysis.
Journal of Membrane Science
Vitenskapelig artikkel
-
Færgestad, Ellen Mosleth;
Rye, Morten Beck;
Nhek, Sarin;
Hollung, Kristin;
Grove, Harald.
(2011)
The Use of Chemometrics to Analyse Protein Patterns from Gel Electrophoresis.
Acta Chromatographica
Vitenskapelig oversiktsartikkel/review
-
Rye, Morten Beck;
Sætrom, Pål;
Håndstad, Tony;
Drabløs, Finn.
(2011)
Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements.
BMC Biology
Vitenskapelig artikkel
-
Håndstad, Tony;
Rye, Morten Beck;
Drabløs, Finn;
Sætrom, Pål.
(2011)
A ChIP-Seq Benchmark Shows That Sequence Conservation Mainly Improves Detection of Strong Transcription Factor Binding Sites.
PLOS ONE
Vitenskapelig artikkel
2008
-
Rye, Morten Beck;
Alsberg, Bjørn Kåre.
(2008)
A multivariate spot filtering model for two-dimensional gel electrophoresis.
Electrophoresis
Vitenskapelig artikkel
-
Rye, Morten Beck;
Færgestad, Ellen Mosleth;
Martens, Harald;
Wold, Jens-Petter;
Alsberg, Bjørn Kåre.
(2008)
An improved pixel-based approach for analyzing images in two-dimensional gel electrophoresis.
Electrophoresis
Vitenskapelig artikkel
-
Rye, Morten Beck;
Mosleth, Ellen Færgestad;
Alsberg, Bjørn Kåre.
(2008)
A new method for assigning common spot boundaries for multiple gels in two-dimensional gel electrophoresis.
Electrophoresis
Vitenskapelig artikkel
-
Rye, Morten Beck;
Feargestad, EM;
Martens, H;
Wold, JP;
Alsberg, Bjørn Kåre.
(2008)
An improved pixel-based approach for analyzing images in two-dimensional gel electrophoresis.
Electrophoresis
Vitenskapelig artikkel
2007
-
Mosleth, Ellen Færgestad;
Rye, Morten Beck;
Walczak, Beata;
Gidskehaug, Lars;
Wold, Jens Petter;
Grove, Harald.
(2007)
Pixel-based analysis of multiple images for the identification of changes: A novel approach applied to unravel proteome patters of 2-D electrophoresis gel images.
Proteomics
Vitenskapelig artikkel
-
Rye, Morten Beck.
(2007)
Image segmentation and multivariate analysis in two-dimensional gel electrophoresis.
Doktoravhandlinger ved NTNU (200)
Doktorgradsavhandling
Tidsskriftspublikasjoner
-
Wess, Maximilian;
Andersen, Maria Karoline;
Midtbust, Elise;
Guillem, Juan Carlos Cabellos;
Viset, Trond;
Størkersen, Øystein.
(2025)
Spatial integration of multi-omics data from serial sections using the novel Multi-Omics Imaging Integration Toolset.
GigaScience
Vitenskapelig artikkel
-
Wess, Maximilian;
Andersen, Maria Karoline;
Midtbust, Elise;
Guillem, Juan Carlos Cabellos;
Viset, Trond;
Størkersen, Øystein.
(2024)
Spatial Integration of Multi-Omics Data using the novel Multi-Omics Imaging Integration Toolset.
bioRxiv
Vitenskapelig artikkel
-
Bergum, Olaug Elisabeth Torheim;
Singleton, Amanda Holstad;
Røst, Lisa Marie Ivarsdatter;
Bodein, Antoine;
Scott-Boyer, Marie-Pier;
Rye, Morten Beck.
(2024)
SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated.
Frontiers in Microbiology
Vitenskapelig artikkel
-
Behsen, Alenka Djarmila;
Holien, Toril;
Micci, Francesca;
Rye, Morten Beck;
Rasmussen, Jenny Malm;
Andersen, Kristin.
(2024)
Cell surface marker heterogeneity in human myeloma cell lines for modeling of disease and therapy.
Scientific Reports
Vitenskapelig artikkel
-
Andersen, Maria K.;
Krossa, Sebastian;
Midtbust, Elise;
Pedersen, Christine Aaserød;
Wess, Maximilian;
Høiem, Therese Stork.
(2024)
Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer.
Communications Biology
Vitenskapelig artikkel
-
Kiviaho, Antti;
Eerola, Sini K.;
Kallio, Heini M.L.;
Andersen, Maria K.;
Hoikka, Miina;
Salonen, Iida.
(2024)
Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer.
Nature Communications
Vitenskapelig artikkel
-
Andersen, Maria Karoline;
Krossa, Sebastian;
Midtbust, Elise;
Pedersen, Christine Aaserød;
Wess, Maximilian;
Høiem, Therese Stork.
(2023)
Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer.
Research Square
Vitenskapelig artikkel
-
Andersen, Maria Karoline;
Krossa, Sebastian;
Midtbust, Elise;
Viset, Trond;
Størkersen, Øystein;
Giskeødegård, Guro F..
(2022)
Multiomics spatial mapping of lipid metabolism in prostate cancer.
European Urology
Sammendrag/abstract
-
Krossa, Sebastian;
Andersen, Maria Karoline;
Midtbust, Elise;
Viset, Trond;
Størkersen, Øystein;
Giskeødegård, Guro.
(2022)
Inflammatory chemokines upregulated in the tumor microenvironment of prostate cancer patients experiencing relapse after radical prostatectomy.
European Urology
Sammendrag/abstract
-
Pedersen, Christine Aaserød;
Cao, Maria Dung;
Fleischer, Thomas;
Rye, Morten Beck;
Knappskog, Stian;
Eikesdal, Hans Petter.
(2022)
DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival.
Breast Cancer Research
Vitenskapelig artikkel
-
Grapotte, Mathys;
Saraswat, Manu;
Bessière, Chloé;
Menichelli, Christophe;
Ramilowski, Jordan A.;
Severin, Jessica.
(2022)
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7).
Nature Communications
Errata
-
Rise, Kjersti;
Tessem, May-Britt;
Drabløs, Finn;
Rye, Morten Beck.
(2022)
FunHoP analysis reveals upregulation of mitochondrial genes in prostate cancer.
PLOS ONE
Vitenskapelig artikkel
-
Misund, Kristine;
Hofste op Bruinink, Davine;
Coward, Eivind;
Hoogenboezem, Remco M.;
Rustad, Even Holth;
Sanders, Mathijs A..
(2022)
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence.
Leukemia
Vitenskapelig artikkel
-
Rye, Morten Beck;
Krossa, Sebastian;
Hall, Martina;
van Mourik, Casper;
Bathen, Tone Frost;
Drabløs, Finn.
(2022)
The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems.
iScience
Vitenskapelig artikkel
-
Hansen, Ailin Falkmo;
Høiem, Therese Stork;
Selnæs, Kirsten Margrete;
Bofin, Anna M.;
Størkersen, Øystein;
Bertilsson, Helena.
(2022)
Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy.
NMR in Biomedicine
Vitenskapelig artikkel
-
Vandsemb, Esten;
Rye, Morten Beck;
Steiro, Ida Johnsen;
Elsaadi, Samah;
Rø, Torstein Baade;
Slørdahl, Tobias Schmidt.
(2021)
PRL-3 induces a positive signaling circuit between glycolysis and activation of STAT1/2.
The FEBS Journal
Vitenskapelig artikkel
-
Rise, Kjersti;
Tessem, May-Britt;
Drabløs, Finn;
Rye, Morten Beck.
(2021)
FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks.
Genomics, Proteomics & Bioinformatics (GPB)
Vitenskapelig artikkel
-
Andersen, Maria Karoline;
Høiem, Therese Stork;
Claes, Britt S.R.;
Balluff, Benjamin;
Marta, Martin-Lorenzo;
Richardsen, Elin.
(2021)
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI.
Cancer & Metabolism
Vitenskapelig artikkel
-
Rauluseviciute, Ieva;
Drabløs, Finn;
Rye, Morten Beck.
(2020)
DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation.
BMC Medical Genomics
Vitenskapelig artikkel
-
Jalili, Mahsa;
Gerdol, Marco;
Greco, S.;
Pallavicini, Alberto;
Buonocore, Francesco;
Scapigliati, Giuseppe.
(2020)
Differential Effects of Dietary Supplementation of Krill Meal, Soybean Meal, Butyrate, and Bactocell® on the Gene Expression of Atlantic Salmon Head Kidney.
International Journal of Molecular Sciences
Vitenskapelig artikkel
-
Zwiggelaar, Rosalie;
Lindholm, Håvard Takle;
Fosslie, Madeleine Lystad;
Pedersen, Marianne Terndrup;
Ohta, Yuki;
Sanchez, Alberto Diez.
(2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.
Science Advances
Vitenskapelig artikkel
-
Grinde, Maria Tunset;
Hilmarsdòttir, Bylgja;
Tunset, Hanna Maja;
Henriksen, Ida Marie;
Kim, Jana;
Haugen, Mads Haugland.
(2019)
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer .
Breast Cancer Research
Vitenskapelig artikkel
-
Vardaxis, Ioannis;
Drabløs, Finn;
Rye, Morten Beck;
Lindqvist, Bo Henry.
(2019)
MACPET: model-based analysis for ChIA-PET.
Biostatistics
Vitenskapelig artikkel
-
Reuluseviciute, Ieva;
Drabløs, Finn;
Rye, Morten Beck.
(2019)
DNA methylation data by sequencing: experimental approaches and recommendations for tools and pipelines for data analysis.
Clinical Epigenetics
Vitenskapelig oversiktsartikkel/review
-
Tekle, Kidane M;
Gundersen, Sveinung;
Klepper, Kjetil;
Bongo, Lars Ailo;
Raknes, Inge Alexander;
Li, Xiaxi.
(2018)
Norwegian e-Infrastructure for Life Sciences (NeLS).
F1000 Research
Vitenskapelig artikkel
-
Andersen, Maria Karoline;
Rise, Kjersti;
Giskeødegård, Guro F.;
Richardsen, Elin;
Bertilsson, Helena;
Størkersen, Øystein.
(2018)
Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma.
Scientific Reports
Vitenskapelig artikkel
-
Rye, Morten Beck;
Bertilsson, Helena;
Andersen, Maria Karoline;
Rise, Kjersti;
Bathen, Tone Frost;
Drabløs, Finn.
(2018)
Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized.
BMC Cancer
Vitenskapelig artikkel
-
Søgaard, Caroline Danielsen;
Moestue, Siver Andreas;
Rye, Morten Beck;
Kim, Jana;
Nepal, Anala;
Liabakk, Nina-Beate.
(2018)
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
OncoTarget
Vitenskapelig artikkel
-
Sandsmark, Elise;
Andersen, Maria Karoline;
Bofin, Anna M.;
Bertilsson, Helena;
Drabløs, Finn;
Bathen, Tone Frost.
(2017)
SFRP4 gene expression is increased in aggressive prostate cancer.
Scientific Reports
Vitenskapelig artikkel
-
Hansen, Ailin Falkmo;
Sandsmark, Elise;
Rye, Morten Beck;
Wright, Alan J;
Bertilsson, Helena;
Richardsen, Elin.
(2016)
Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer.
OncoTarget
Vitenskapelig artikkel
-
Sandsmark, Elise;
Hansen, Ailin Falkmo;
Selnæs, Kirsten Margrete;
Bertilsson, Helena;
Bofin, Anna M.;
Wright, Alan J..
(2016)
A novel non-canonical Wnt signature for prostate cancer aggressiveness.
OncoTarget
Vitenskapelig artikkel
-
Vandsemb, Esten Nymoen;
Bertilsson, Helena;
Abdollahi, Pegah;
Størkersen, Øystein;
Våtsveen, Thea Kristin;
Rye, Morten Beck.
(2016)
Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Tessem, May-Britt;
Bertilsson, Helena;
Angelsen, Anders;
Bathen, Tone Frost;
Drabløs, Finn Sverre;
Rye, Morten Beck.
(2016)
A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer.
PLOS ONE
Vitenskapelig artikkel
-
Hurst, Laurence D.;
Ghanbarian, Avazeh T.;
Forrest, Alistair R.R.;
Huminiecki, Lukasz;
Haberle, Vanja;
Drabløs, Finn Sverre.
(2015)
The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome.
PLoS Biology
Vitenskapelig artikkel
-
Rydbeck, Halfdan;
Sandve, Geir Kjetil F.;
Ferkingstad, Egil;
Simovski, Boris;
Rye, Morten Beck;
Hovig, Johannes Eivind.
(2015)
ClusTrack: Feature extraction and similarity measures for clustering of genome-wide data sets.
PLOS ONE
Vitenskapelig artikkel
-
Forest, Alistair R.R.;
Kawaji, Hideya;
Rehli, Michael;
Baillie, John Kenneth;
de Hoon, Michiel;
Haberle, Vanja.
(2014)
A promoter-level mammalian expression atlas.
Nature
Vitenskapelig artikkel
-
Rye, Morten Beck;
Bertilsson, Helena;
Drabløs, Finn;
Angelsen, Anders;
Bathen, Tone Frost;
Tessem, May-Britt.
(2014)
Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer.
BMC Medical Genomics
Vitenskapelig artikkel
-
Rye, Morten Beck;
Sandve, Geir Kjetil F.;
Daub, Carsten O;
Kawaji, H;
Carninci, P;
Forrest, A.
(2014)
Chromatin states reveal functional associations for globally defined transcription start sites in four human cell lines.
BMC Genomics
Vitenskapelig artikkel
-
Sandve, Geir Kjetil;
Gundersen, Sveinung;
Johansen, Morten;
Glad, Ingrid Kristine;
Gunathasan, Krishanthi;
Holden, Lars.
(2013)
The Genomic HyperBrowser: an analysis web server for genome-scale data.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Hofsli, Eva;
Sjursen, Wenche;
Prestvik, Wenche S;
Johansen, Jostein;
Rye, Morten Beck;
Tranø, Gerd.
(2013)
Identification of serum microRNA profiles in colon cancer.
British Journal of Cancer
Vitenskapelig artikkel
-
Rye, Morten Beck;
Færgestad, Ellen Mosleth.
(2012)
Preprocessing of electrophoretic images in 2-DE analysis.
Chemometrics and Intelligent Laboratory Systems
Vitenskapelig artikkel
-
Kornacker, K;
Rye, Morten Beck;
Håndstad, Tony;
Drabløs, Finn.
(2012)
The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding.
BMC Bioinformatics
Vitenskapelig artikkel
-
Håndstad, Tony;
Rye, Morten Beck;
Mocnik, Rok;
Drabløs, Finn;
Sætrom, Pål.
(2012)
Cell-type specificity of ChIP-predicted transcription factor binding sites.
BMC Genomics
Vitenskapelig artikkel
-
Rye, Morten Beck;
Sætrom, Pål;
Drabløs, Finn.
(2011)
A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Sun, Cheng;
Fiksdal, Liv;
Hanssen-Bauer, Audun;
Rye, Morten Beck;
Leiknes, TorOve.
(2011)
Characterization of membrane biofouling at different operating conditions (flux) in drinking water treatment using confocal laser scanning microscopy (CLSM) and image analysis.
Journal of Membrane Science
Vitenskapelig artikkel
-
Færgestad, Ellen Mosleth;
Rye, Morten Beck;
Nhek, Sarin;
Hollung, Kristin;
Grove, Harald.
(2011)
The Use of Chemometrics to Analyse Protein Patterns from Gel Electrophoresis.
Acta Chromatographica
Vitenskapelig oversiktsartikkel/review
-
Rye, Morten Beck;
Sætrom, Pål;
Håndstad, Tony;
Drabløs, Finn.
(2011)
Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements.
BMC Biology
Vitenskapelig artikkel
-
Håndstad, Tony;
Rye, Morten Beck;
Drabløs, Finn;
Sætrom, Pål.
(2011)
A ChIP-Seq Benchmark Shows That Sequence Conservation Mainly Improves Detection of Strong Transcription Factor Binding Sites.
PLOS ONE
Vitenskapelig artikkel
-
Rye, Morten Beck;
Alsberg, Bjørn Kåre.
(2008)
A multivariate spot filtering model for two-dimensional gel electrophoresis.
Electrophoresis
Vitenskapelig artikkel
-
Rye, Morten Beck;
Færgestad, Ellen Mosleth;
Martens, Harald;
Wold, Jens-Petter;
Alsberg, Bjørn Kåre.
(2008)
An improved pixel-based approach for analyzing images in two-dimensional gel electrophoresis.
Electrophoresis
Vitenskapelig artikkel
-
Rye, Morten Beck;
Mosleth, Ellen Færgestad;
Alsberg, Bjørn Kåre.
(2008)
A new method for assigning common spot boundaries for multiple gels in two-dimensional gel electrophoresis.
Electrophoresis
Vitenskapelig artikkel
-
Rye, Morten Beck;
Feargestad, EM;
Martens, H;
Wold, JP;
Alsberg, Bjørn Kåre.
(2008)
An improved pixel-based approach for analyzing images in two-dimensional gel electrophoresis.
Electrophoresis
Vitenskapelig artikkel
-
Mosleth, Ellen Færgestad;
Rye, Morten Beck;
Walczak, Beata;
Gidskehaug, Lars;
Wold, Jens Petter;
Grove, Harald.
(2007)
Pixel-based analysis of multiple images for the identification of changes: A novel approach applied to unravel proteome patters of 2-D electrophoresis gel images.
Proteomics
Vitenskapelig artikkel
Rapport
-
Rye, Morten Beck.
(2007)
Image segmentation and multivariate analysis in two-dimensional gel electrophoresis.
Doktoravhandlinger ved NTNU (200)
Doktorgradsavhandling
UTSTILLING
-
Emdal, Elisabeth Fritzke;
Ottestad, Anine Larsen;
Vågbø, Cathrine Broberg;
Skarpeteig, Veronica ;
Rye, Morten Beck.
(2022)
Prøv deg som en DNA-detektiv.
Forskningstorget 2022
Annen presentasjon
Informasjonsmateriell
-
Tessem, May-Britt;
Rye, Morten Beck.
(2014)
Early markers of a potentially dangerous type of prostate cancer.
Nettsider (opplysningsmateriale)
Undervisning
Emner
Formidling
2025
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PosterTelumyan, Elen; Martín Gracia, Beatriz; Sagini, Krizia; Andersen, Maria K.; Tessem, May-Britt; Rye, Morten Beck. (2025) Optimizing Protocols for Seminal Extracellular Vesicle Isolation in Prostate Cancer Research. International Society of Extracellular Vesicles ISEV2025 Annual Meeting , Vienna, Austria 2025-04-23 - 2025-04-27
2024
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Vitenskapelig foredragWess, Maximilian; Andersen, Maria Karoline; Midtbust, Elise; Guillem, Juan Carlos Cabellos; Viset, Trond; Størkersen, Øystein. (2024) Integration of Spatial Transcriptomics and Mass Spectrometry Imaging using MIIT. VIB Conference Spatial Omics , Ghent, Belgium 2024-06-13 - 2024-06-14
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PosterAndersen, Maria Karoline; Krossa, Sebastian; Midtbust, Elise; Pedersen, Christine Aaserød; Wess, Maximilian; Viset, Trond. (2024) Spatial transcriptomics reveals biomarker SFRP4 to be strongly associated with extracellular matrix remodeling in prostate cancer stroma. VIB Spatial Omics , Gent 2024-06-13 - 2024-06-14
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PosterTelumyan, Elen; Martín Gracia, Beatriz; Sagini, Krizia; Andersen, Maria K.; Llorente, Alicia; Tessem, May-Britt. (2024) Transcriptomic Biomarker for Prostate Cancer Active Surveillance in Extracellular Vesicles from Liquid Biopsies. Institute for Cancer Research at Oslo University Hospital The Norwegian Cancer Symposium , Oslo 2024-09-09 - 2024-09-10
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Vitenskapelig foredragSharma, Abhibhav; Wess, Maximilian; Andersen, Maria K.; Rye, Morten Beck; Krossa, Sebastian; Midtbust, Elise. (2024) Spatial multi-omics characterization of epithelial glands reveals novel prognostic signatures in prostate cancer . 20th Annual International Conference of the Metabolomics Society , Osaka 2024-06-16 - 2024-06-20
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Vitenskapelig foredragSharma, Abhibhav; Wess, Maximilian; Andersen, Maria K.; Rye, Morten Beck; Krossa, Sebastian; Midtbust, Elise. (2024) Spatial multi-omics characterization of epithelial glands reveals novel prognostic signatures in prostate cancer . 4th-Nordic Metabolomic Conference 2024 , Turku 2024-08-25 - 2024-08-28
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PosterSingh, Mithlesh Prasad; Wess, Maximilian; Rye, Morten Beck; Lehti, Kaisa Irene; Tessem, May-Britt; Andersen, Maria K.. (2024) Unveiling Spatial Metabolism in Prostate Cancer Tissue: Applying Explainable Machine Learning to Mass Spectrometry Imaging Data. Biomarker Discovery with MSI and Explainable Machine Learning. VIB-KU Leuven Spatial Omics 2024 a VIB Tools and Technologies conference , Ghent 2024-06-13 - 2024-06-14
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PosterTelumyan, Elen; Martín Gracia, Beatriz; Sagini, Krizia; Andersen, Maria K.; Llorente, Alicia; Tessem, May-Britt. (2024) A Transcriptomic Biomarker for Prostate Cancer Active Surveillance in Extracellular Vesicles from Liquid Biopsies . Institute for Cancer Research at Oslo University Hospital CanCell Annual Retreat , Stromstad 2024-10-09 - 2024-10-10
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PosterTelumyan, Elen; Martín Gracia, Beatriz; Sagini, Krizia; Andersen, Maria K.; Llorente, Alicia; Tessem, May-Britt. (2024) Transcriptomic Biomarker for Prostate Cancer Active Surveillance in Extracellular Vesicles from Liquid Biopsies. Cambridge University Precision EV Forum 2024 , Cambridge 2024-10-23 - 2024-10-24
2023
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Vitenskapelig foredragWess, Maximilian; Andersen, Maria Karoline; Midtbust, Elise; Krossa, Sebastian; Rye, Morten Beck; Tessem, May-Britt. (2023) Integration of Spatial Multi-Omics Data for Prostate Cancer Classification. Swedish Academy of Pharmaceutical Sciences Regional Mass Spectrometry Imaging Spring Workshop , Uppsala, Swede 2023-03-27 - 2023-03-29
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Vitenskapelig foredragWess, Maximilian; Andersen, Maria Karoline; Midtbust, Elise; Krossa, Sebastian; Rye, Morten Beck; Tessem, May-Britt. (2023) Registration-based Integration of Spatial Multi-Omics Data for Prostate Cancer Classification. NTNU The 3rd Nordic Metabolomics Conference , Trondheim, Norway 2023-10-18 - 2023-10-20
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PosterWess, Maximilian; Andersen, Maria Karoline; Midtbust, Elise; Krossa, Sebastian; Rye, Morten Beck; Tessem, May-Britt. (2023) Prostate Cancer Classification using Registration-based Integration of Spatial Multi-Omics Data. NTNU NTNU Health , Trondheim, Norway 2023-10-23 - 2023-10-23
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PosterWess, Maximilian; Andersen, Maria Karoline; Midtbust, Elise; Guillem, Juan Carlos Cabellos; Krossa, Sebastian; Rye, Morten Beck. (2023) Registration-based Integration of Spatially Resolved Multi-Omics Data for Prostate Cancer Classification. PRESIMAL PRESIMAL Autumn Research School 2023 , Sommarøya, Norway 2023-09-13 - 2023-09-15
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Vitenskapelig foredragAndersen, Maria Karoline; Midtbust, Elise; Krossa, Sebastian; Viset, Trond; Størkersen, Øystein; Vandenbosch, Michiel. (2023) Spatial multiomics show lipid metabolism alterations in prostate cancer. Regional Mass Spectrometry Imaging Spring Workshop , Uppsala 2023-04-27 - 2023-04-29
2022
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Vitenskapelig foredragKrossa, Sebastian; Andersen, Maria Karoline; Midtbust, Elise; Wess, Maximilian; Viset, Trond; Størkersen, Øystein. (2022) Inflamed normal appearing glands in the tumor microenvironment of prostate cancer are associated with relapse after radical prostatectomy. Norsk Biokjemisk Selskap NBS Contact Meeting 2022 , Tromsø 2022-02-10 - 2022-02-12
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Vitenskapelig foredragAndersen, Maria Karoline; Krossa, Sebastian; Midtbust, Elise; Pedersen, Christine Aaserød; Wess, Maximillian; Viset, Trond. (2022) Spatial transcriptomics reveals biomarker SFRP4 to be strongly associated with extracellular matrix remodeling in prostate cancer stroma. University of Oslo The Norwegian Cancer Symposium 2022 , Oslo 2022-09-14 - 2022-09-15
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PosterAndersen, Maria Karoline; Krossa, Sebastian; Midtbust, Elise; Høiem, Therese Stork; Viset, Trond; Størkersen, Øystein. (2022) Multiomics spatial analysis shows lipid metabolism alterations in prostate cancer. CA19105 EpiLipidNET Cost Action 3rd EpiLipidNET Action Meeting , Aveiro 2022-09-21 - 2022-09-23
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PosterPedersen, Christine Aaserød; Midtbust, Elise; Krossa, Sebastian; Andersen, Maria Karoline; Viset, Trond; Størkersen, Øystein. (2022) DNA methylation aberrations predicts recurrence both in tumor and normal appearing prostate tissue. European Association of Urology European Association of Urology conference 2022 , Amsterdam 2022-06-30 - 2022-07-04
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PosterKrossa, Sebastian; Andersen, Maria Karoline; Midtbust, Elise; Wess, Maximilian; Viset, Trond; Størkersen, Øystein. (2022) Inflamed normal appearing glands in the tumor microenvironment of prostate cancer are associated with relapse after radical prostatectomy. The Norwegian Cancer Symposium 2022 2022-09-14 - 2022-09-15
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PosterAndersen, Maria Karoline; Krossa, Sebastian; Midtbust, Elise; Høiem, Therese Stork; Viset, Trond; Størkersen, Øystein. (2022) Multiomics spatial analysis shows lipid metabolism alterations in prostate cancer. Digitalt Life Digital Life Conference 2022 , Trondheim 2022-10-20 - 2022-10-21
2021
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Vitenskapelig foredragWess, Maximilian; Andersen, Maria Karoline; Krossa, Sebastian; Rye, Morten Beck; Tessem, May-Britt. (2021) Spatial Integration of Multi-Omics Data for Prostate Cancer Classification. Institut Curie Computational Systems Biology of Cancer multiomics and machine learning , Virtual 2021-09-27 - 2021-10-01
2020
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Vitenskapelig foredragRye, Morten Beck; Bertilsson, Helena; Krossa, Sebastian; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt. (2020) A gene signature for citrate and spermine (CS) secretion in the prostate. Sahlgrenska Academy, University of Gothenburg Swedish Symposium on Prostate Cancer Research , Gøteborg 2020-02-03 - 2020-02-04
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Vitenskapelig foredragRise, Kjersti; Tessem, May-Britt; Drabløs, Finn; Rye, Morten Beck. (2020) How FunHoP changed the picture. Mabalacat City College MCC International Webinar Series 2020-10-10 -
2019
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Faglig foredragRye, Morten Beck; Nygård, Ståle; Drabløs, Finn; Petersen, Kjell; Våge, Dag Inge; Willassen, Nils Peder. (2019) ELIXIR.NO - The national infrastructure of bioinformatics. Norsk Biokjemisk Selskap Norwegian Biochemical Society 55th Contact Meeting , Røros 2019-01-24 - 2019-01-27
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Faglig foredragRye, Morten Beck; Bertilsson, Helena; Krossa, Sebastian; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt. (2019) The genes controlling citrate and spermine secretion in prostate cancer. Norsk Biokjemisk Selskap Norwegian Biochemical Society 55th Contact Meeting , Røros 2019-01-24 - 2019-01-27
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Faglig foredragRye, Morten Beck; Tessem, May-Britt; Krossa, Sebastian; Bathen, Tone Frost; Drabløs, Finn; Bertilsson, Helena. (2019) The expression of genes controlling citrate and spermine secretion is lost in aggressive prostate cancer and metastasis. Nordisk Urologisk Forening The 32nd NUF Congress , Reykjavik 2019-08-05 - 2019-08-08
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PosterJalili, Mahsa; Gerdol, Marco; Greco, Samuele; Pallavicini, Alberto; Buonocore, Francesco; Scapigliati, Giuseppe. (2019) Altered transcription levels of immune markers in head kidney of Atlantic salmon after different feedings. Scandinavian Society of Immunology Scandinavian Society of Immunology conference 2019-12-01 -
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PosterAndersen, Maria Karoline; Høiem, Therese Stork; Balluff, Benjamin; Claes, Britt S.R.; Martin-Lorenzo, Marta; Richardsen, Elin. (2019) Altered metabolism in prostate cancer and stroma detected through MALDI-TOF MSI. Metabolomics Society Metabolomics 2019 , The Hague 2019-06-23 - 2019-06-27
2018
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PosterAndersen, Maria Karoline; Rise, Kjersti; Giskeødegård, Guro F.; Richardsen, Elin; Bertilsson, Helena; Størkersen, Øystein. (2018) Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma. ISMRM ISMRM Workshop on Advances in Multiscale Cancer Detection: From Micro to Macro , Dublin 2018-10-07 - 2018-10-10
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PosterAndersen, Maria Karoline; Høiem, Therese Stork; Balluff, Benjamin; Martin-Lorenzo, Marta; Richardsen, Elin; Bertilsson, Helena. (2018) Altered metabolism in prostate cancer and stroma detected through MALDI-TOF MSI. IMSS IMSS II & OurCon VI Joint Meeting , Charleston 2018-11-11 - 2018-11-14
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PosterRise, Kjersti; Drabløs, Finn; Rye, Morten Beck. (2018) FunHoP – Enhanced visualisation and analysis of functionally homologous proteins in complex metabolic networks. International Study Group for Systems Biology 2018-09-24 - 2018-09-28
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PosterRise, Kjersti; Drabløs, Finn; Rye, Morten Beck. (2018) Cell Lines vs. Tissue - A Comparative Study of Gene Expression Using FunHoP. International Conference on Systems Biology 2018-10-28 - 2018-11-01
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PosterRye, Morten Beck; Bertilsson, Helena; Andersen, Maria Karoline; Rise, Kjersti; Bathen, Tone Frost; Drabløs, Finn. (2018) Computational minimization of stroma tissue confounding reveals systematic downregulation of cholesterol synthesis pathway genes in prostate cancer . Hellenic Society for Computational Biology and Bioinformatic ECCB 2018 - 17th European Conference on Computational Biology , Athen 2018-09-08 - 2918-09-12
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Populærvitenskapelig foredragRye, Morten Beck. (2018) When Prostate Cancer Becomes Dangerous!. Medisinsk Fakultet Health Innovation Seminar , Trondheim 2018-03-21 - 2018-03-21
2017
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Vitenskapelig foredragRye, Morten Beck; Bertilsson, Helena; Andersen, Maria Karoline; Rise, Kjersti; Bathen, Tone Frost; Drabløs, Finn. (2017) Transcriptional downregulation of cholesterol synthesis pathway genes in prostate cancer. NBS - Norsk Biokjemisk Selskap The 53rd Contact Meeting , Storefjell Resort Hotel, Gol 2017-01-19 -
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Vitenskapelig foredragRye, Morten Beck; Bertilsson, Helena; Andersen, Maria Karoline; Rise, Kjersti; Bathen, Tone Frost; Drabløs, Finn. (2017) Computational assessment of tissue heterogeneity in patient tissue samples reveals that cholesterol synthesis pathway genes in prostate cancer are consistently downregulated. Swiss Institute of Bioinformatics BC2 Computational Biology Conference , Basel 2017-09-12 - 2017-09-15
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Vitenskapelig foredragRye, Morten Beck; Tessem, May-Britt; Andersen, Maria Karoline; Rise, Kjersti; Bathen, Tone Frost; Drabløs, Finn. (2017) Cholesterol synthesis pathway genes in prostate cancer are downregulated. Scandinavian Association of Urology 31st NUF Congress , Odense 2017-06-14 - 2017-06-16
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Vitenskapelig foredragRise, Kjersti; Drabløs, Finn; Rye, Morten Beck. (2017) Aggregating RNA-Seq reads from multiple genes in KEGG metabolic pathways improves interpretability in gene expression pathway analysis. International Conference on Systems Biology , Blacksburg, Virginia 2017-08-06 - 2017-08-12
2016
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PosterSandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J. (2016) A novel non-canonical wnt signature associated with Gleason score, recurrence, metastases and metabolic alterations in prostate cancer. The 8th National PhD Conference in Medical Imaging 2016-11-21 - 2016-11-22
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Faglig foredragRye, Morten Beck; Bertilsson, Helena; Andersen, Maria Karoline; Rise, Kjersti; Bathen, Tone Frost; Drabløs, Finn Sverre. (2016) Transcriptional downregulation of cholesterol synthesis revealed as a hallmark for prostate cancer after adjustment for confounding stroma. EAU- european Association of Urology ESUR16 - 23rd Meeting of the EAU Section of Urological Research , Parma 2016-10-20 - 2016-10-22
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Vitenskapelig foredragSandsmark, Elise; Hansen, Ailin Falkmo; Bertilsson, Helena; Selnæs, Kirsten Margrete; Wright, Alan; Bofin, Anna M.. (2016) Non-canonicle Wnt5a signalling is associated with EMT and metabolic alterations in human prostate cancer. NTNU Current and Future Clinical Biomarkers of Cancer , Trondheim 2016-06-16 - 2016-06-17
2015
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PosterSandsmark, Elise; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan; Viset, Trond. (2015) Non-canonical Wnt5a-Fizzled2 signaling is associated with metabolic reprogramming and biochemical recurrence in human prostate cancer. ESUR-SBUR15 - The 11th World Congress on Urological Research , Nijmegen 2015-09-10 - 2015-09-12
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Vitenskapelig foredragHansen, Ailin Falkmo; Sandsmark, Elise; Rye, Morten Beck; Wright, Alan; Bertilsson, Helena; Sjøbakk, Torill Eidhammer. (2015) TMPRSS2:ERG gene fusion in human prostate cancer is associated with altered metabolism. Norsk Biokjemisk Selskap NBS contact meeting Svalbard , Svalbard 2015-02-09 - 2015-02-13
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Vitenskapelig foredragHansen, Ailin Falkmo; Sandsmark, Elise; Rye, Morten Beck; Wright, Alan; Bertilsson, Helena; Bofin, Anna M.. (2015) TMPRSS2:ERG gene fusion and ERG overexpression in human prostate cancer are associated with changed metabolism. ISMRM 2015 , Toronto 2015-05-30 - 2015-07-05
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Vitenskapelig foredragSandsmark, Elise; Hansen, Ailin Falkmo; Bertilsson, Helena; Selnæs, Kirsten Margrete; Wright, Alan J; Axcrona, K. (2015) Non-canonical Wnt5a signalling is associated with EMT and metabolic alterations in human prostate cancer. ESMRMB 2015 Congress 2015-10-01 - 2015-10-03
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PosterSandsmark, Elise; Hansen, Ailin Falkmo; Rye, Morten Beck; Wright, Alan; Bertilsson, Helena; Sjøbakk, Torill Eidhammer. (2015) TMPRSS2:ERG gene fusion in human prostate cancer shows decreased levels of citrate and spermine . Helse Nord-Trøndelag Regional forskningskonferanse i Helse Midt-Norge , Sjørdal 2015-06-09 - 2015-06-10
2014
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Vitenskapelig foredragRye, Morten Beck; Bertilsson, Helena; Drabløs, Finn; Angelsen, Anders; Bathen, Tone Frost; Tessem, May-Britt. (2014) Subtype classification of prostate cancer. IKM Onsdagsmøte, IKM , Kunnskapssenteret, St.Olav 2014-01-15 - 2014-01-15
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Vitenskapelig foredragRye, Morten Beck; Sandve, Geir Kjetil F.; Daub, Carsten O; Kawaji, Hideya; Carninci, Piero; Forrest, Alistair. (2014) Repressed promoters in active chromatin. Society for Bioinformatics in Northern Europe (SocBiN) SocBiN Bioinformatics 2014 , Oslo 2014-06-11 - 2014-06-13
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Vitenskapelig foredragRye, Morten Beck; Bertilsson, Helena; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt. (2014) Tissue heterogeneity and data integration in prostate cancer. Program for Bioinformatikk (PBI) Bioinformatics Network Seminar: Biological networks – from genes to populations , Sumhuset, Trondheim 2014-12-08 - 2014-12-08
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PosterRye, Morten Beck; Bertilsson, Helena; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt. (2014) Simplifying methods for adjusting tissue heterogeneity pinpoint genes responsible for altered metabolism in prostate cancer samples. EAU Section of Urological Research (ESUR) ESUR 2014 , Glasgow, Scotland 2014-10-09 - 2014-10-11
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PosterRye, Morten Beck; Sandve, Geir Kjetil F.; Daub, Carsten O; Kawaji, Hideya; Carninci, Piero; Forrest, Alistair. (2014) Chromatin data integrated with a human reference atlas of experimentally defined promoters reveal repressed promoters located in active chromatin. Society for Bioinformatics in Northern Europe (SocBiN) SocBiN Bioinformatics 2014 , Oslo 2014-06-11 - 2014-06-13
2013
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Vitenskapelig foredragRye, Morten Beck. (2013) Chromatin states reveal functional associations for globally defined transcription start sites in four human cell lines. Karolinska Institut Faglig besøk til Karolinska Institut , Stockholm 2013-04-12 - 2013-04-12
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PosterKornacker, Karl; Rye, Morten Beck; Håndstad, Tony; Drabløs, Finn. (2013) The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding. COST TD801 StatSeq 5th StatSeq Workshop , Helsinki 2013-04-24 - 2013-04-26
2012
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Vitenskapelig foredragDrabløs, Finn; Kornacker, Karl; Rye, Morten Beck; Håndstad, Tony. (2012) The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding. Norwegian Bioinformatics Forum , Trondheim 2012-10-18 - 2012-10-19
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Vitenskapelig foredragDrabløs, Finn; Rye, Morten Beck; Klepper, Kjetil; Sætrom, Pål. (2012) Definition and analysis of gene sets from time series data. FANTOM RIKEN FANTOM time-courses meeting , Yokohama 2012-10-29 - 2012-11-02
2011
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PosterRye, Morten Beck; Drabløs, Finn; Sætrom, Pål; Håndstad, Tony. (2011) Epigenetic Influence on Cell-type specific peaks from ChIP-Seq data. Keystone Symposia Histone code: Fact or fiction? , Midway, Utah 2011-01-10 - 2011-01-15
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PosterRye, Morten Beck; Sætrom, Pål; Håndstad, Tony; Drabløs, Finn. (2011) Clusters of ChIP-Seq defined transcription factor binding sites map regulatory elelemnts in the human genome. Cambridge Research Institute Unanswered Questions in Transcription, Annual international Symposium , Cambridge 2011-11-04 - 2011-11-05
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Vitenskapelig foredragRye, Morten Beck. (2011) Transcription factors and histone modifications. Joint Friday meeting, Systems Biology and BiGR group 2011-03-10 -
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Vitenskapelig foredragRye, Morten Beck. (2011) Transcription factors and histone modifications. FUGE, Bergen BFYS 2011 (Bioinformatics for young scientists) , Ullensvang 2011-03-16 - 2011-03-18
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Vitenskapelig foredragRye, Morten Beck. (2011) Epigenetics and SNPs. eGenVar kickoff meating , NTNU, Trondheim 2011-03-25 -
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Vitenskapelig foredragRye, Morten Beck. (2011) Chemometrics in Medicine. Faggruppa for Kjemometri Seminar i forbindelse med årsmøte i faggruppa for kjemometri , NTNU, Trondheim 2011-04-04 -
2010
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Vitenskapelig foredragRye, Morten Beck. (2010) A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs. NBF, Norwegian Bioinformatics Forum 2010 , Radiumhospitalet, Oslo 2010-11-18 - 2010-11-19
2009
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ProgramdeltagelseElvestad, Maiken Bratt; Gjerde, Anne Heidi; Hanssen-Bauer, Audun; Fladvad, Torill; Gilljam, Karin Margaretha; Bergstrøm, Bjarte. (2009) Forskningsdagene 2009. Forskningstorget Forskningstorget [TV] 2009-09-25
2008
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PosterFærgestad, Ellen Mosleth; Høy, Martin; Grove, Harald; Gidskehaug, Lars; Moldestad, Anette Aamodt; Hollung, Kristin. (2008) An improved and rapid method for analysis of 2-DE images; a pixel based approach. FROM GENOME TO PROTEOME: INTEGRATION AND PROTEOME COMPLETION , Siena, Italy 2008-08-31 - 2008-09-04
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PosterMartens, Harald; Høy, Martin; Grove, Harald; Moldestad, Anette; Hollung, Kristin; Rye, Morten Beck. (2008) An improved and rapid method for analysis of 2-DE images; a pixel based approach. 8, Siena Meeting: From genome to proteome , Siena, italy 2008-08-28 - 2008-09-04
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PosterRye, Morten Beck. (2008) Pixel-based approach for identifying significant features in two-dimensional gel electrophoresis. Iris NPC2008, 4th Annual Norwegian Proteomics Conference , Ulstein 2008-10-20 - 2008-10-21
2006
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Vitenskapelig foredragRye, Morten Beck; Alsberg, Bjørn Kåre. (2006) Separering av proteinsegment fra støysegment ved DPLSR i 2D gel elektroforese. 18. norske kjemometrisymposium , Hafjell 2006-03-20 - 2006-03-22
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PosterRye, Morten Beck; Alsberg, Bjørn Kåre. (2006) Automatic spot classification in 2DE gel analysis. 7th Siena Meeting From Genome To Proteome , Siena 2006-09-03 - 2006-09-07
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PosterRye, Morten Beck; Mosleh Færgestad, Ellen; Grove, Harald; Van Der Berg, Franz; Martens, Harald; Hollung, Kristin. (2006) Viewing Images As Spectra: A Novel approach of analysing 2DE proteome data. 7th Siena Meeting. From Genome To Proteome , Siena 2006-09-03 - 2006-09-07
2005
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Vitenskapelig foredragRye, Morten Beck; Alsberg, Bjørn Kåre. (2005) Comparing Segmentation methods in Two-Dimensional Gel Electrophoresis. BFYS 2005 2005-04-15 - 2005-04-17
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PosterRye, Morten Beck; Alsberg, Bjørn Kåre. (2005) Protein spot classification by PLSR in two dimensional gel electrophoresis. SSC9 - 9th Scandinavian Symposium on Chemometrics 2005-08-21 - 2005-08-25