Øyvind Halaas
Øyvind Halaas
Professor i medisin (nanomedisin)
Institutt for klinisk og molekylær medisin Fakultet for medisin og helsevitenskapBakgrunn og aktiviteter
Vår forskning forskning dreier seg rundt mikrofysiologiske systemer (MPS) for immunsystemet i helse og sykdom. Immunsystemet er komplekst cellebiologisk, men relativt enkelt anatomisk. Vi har valgt en vev-på-brikke-tilnærming for å etterlikne flere av funksjonene av immunsystemet, slik som migrasjon, T celleutvikling og immuneffekter i sykt vev, for bedre å kunne drive forskning og utvikloing på viktige komopnenter til bruk i immunterapi.
Vitenskapelig, faglig og kunstnerisk arbeid
Et utvalg av nyere tidsskriftspublikasjoner, kunstneriske produksjoner, bok, inklusiv bokdeler og rapport-del. Se alle publikasjoner i databasen
Tidsskriftspublikasjoner
- (2019) A novel lab-on-chip platform enabling axotomy and neuromodulation in a multi-nodal network. Biosensors & bioelectronics. vol. 140:111329.
- (2018) Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination. Frontiers in Immunology. vol. 9:650.
- (2018) Structuring a multi-nodal neural network in vitro within a novel design microfluidic chip. Biomedical microdevices. vol. 20:9.
- (2016) The intercell dynamics of T cells and dendritic cells in a lymph node-on-a-chip flow device. Lab on a Chip. vol. 16.
- (2016) Abstract A008: Photochemical internalization: Light-induced enhancement of MHC Class I antigen presentation, giving strong enhancement of cytotoxic T-cell responses to vaccination. Cancer immunology research. vol. 4 (11).
- (2015) Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proceedings of the National Academy of Sciences of the United States of America. vol. 112 (31).
- (2015) Seeing a mycobacterium-infected cell in nanoscale 3D: Correlative imaging by light microscopy and FIB/SEM tomography. PLOS ONE. vol. 10:e0134644 (9).
- (2015) Infection and immunity on a chip: A compartmentalised microfluidic platform to monitor immune cell behaviour in real time. Lab on a Chip. vol. 15 (6).
- (2013) Dynamics of immune effector mechanisms during infection with Mycobacterium aviumin C57BL/6 mice. Immunology. vol. 140 (2).
- (2010) Intracellular Mycobacterium avium Intersect Transferrin in the Rab11(+) Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway. Journal of Infectious Diseases. vol. 201 (5).
- (2010) The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes. Immunity. vol. 33 (4).
- (2009) IL-10 Enhances MD-2 and CD14 Expression in Monocytes and the Proteins Are Increased and Correlated in HIV-Infected Patients. Journal of Immunology. vol. 182 (1).
- (2007) The journey of Toll-like receptors in the cell. Advances in Experimental Medicine and Biology. vol. 598.
- (2006) Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO Journal. vol. 25.
- (2004) Monocytes stimulated with group B Streptococci or interferons release tumour necrosis factor-related apoptosis-inducing ligand. Scandinavian Journal of Immunology. vol. 60 (1-2).
- (2002) Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. Journal of Biological Chemistry. vol. 277 (38).
- (2001) Differential expression of Toll-like receptor 2 in human cells. Journal of Leukocyte Biology. vol. 69.
- (2001) Nonlabeled Secondary Antibodies Augment/Maintain the binding of Primarym Specific Antibodies to Cell Membrane Antigens. Cytometry. vol. 45.
- (2000) Human Toll-like Receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. Journal of Immunology. vol. 164.
- (2000) Immune stimulating properties of di-equatorially beta(1->4) linked poly-uronides. Proceedings of the Phytochemical Society of Europe. vol. 44.