Tone Frost Bathen
Bakgrunn og aktiviteter
MR Cancer gruppen studerer funksjonelle og metabolske egenskaper i kreft ved hjelp av magnetisk resonans (MR) avbildning og spektroskopi. Ved å utvikle, anvende og optimalisere MR metodikk (i kombinasjon med andre molekylære metoder) for å karakterisere sykdom, er vårt mål å etablere bedre diagnostiske metoder som har prognostisk verdi (i.e. etablerere og validere biomarkører), og som kan stratifisere pasienter til riktig behandling. Våre to største fokusområder er brystkreft og prostatakreft, og vi jobber med vevsprøver og biofluids fra store biobanker, prekliniske dyremodeller og kliniske pasientstudier. I tillegg driver gruppen utstrakt biomedisinsk forskning basert på MR-metodikk i bred forstand; vi er involvert i flere studier med problemstillinger knyttet til hjerte-karsykdom, svangerskapsforgiftning og utprøving av nye kontrastmidler.
Publikasjoner registrert i PubMed:
https://www.ncbi.nlm.nih.gov/pubmed/?term=Bathen+TF
Emner
- KLMED8014 - Forskningsmetoder i radiologi og nukleærmedisin
- RAT3901 - Masteroppgave i medisinsk bildeteknologi
- RAT3001 - Introduksjon til medisinsk bildeteknologi
- MEDT8010 - Metabolomics- Metoder og praktisk anvendelse
- RAT3104 - Avansert MR-fysikk: generelle metoder
- RAT3002 - Bildebehandling og automatisert klassifisering
Vitenskapelig, faglig og kunstnerisk arbeid
Viser et utvalg av aktivitet. Se alle publikasjoner i databasen
2015
- (2015) In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts. Journal of Magnetic Resonance Imaging. vol. 41 (3).
2014
- (2014) Metabolomic biomarkers in serum and urine in women with preeclampsia. PLOS ONE. vol. 9 (3:e91923).
- (2014) Impacts of MR spectroscopic imaging on glioma patient management. Acta Oncologica. vol. 53 (5).
- (2014) Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts. Magnetic Resonance in Medicine. vol. 71 (6).
- (2014) Interplay of choline metabolites and genes in patient-derived breast cancer xenografts. Breast Cancer Research. vol. 16 (1).
2013
- (2013) Changes in Levels of Metabolomic Biomarkers in Serum and Urine in Women with Preeclampsia. Magnetic Resonance Materials in Physics, Biology and Medicine. vol. 26 (1).
- (2013) Metabolomic biomarkers in serum and urine of preeclamptic women. Pregnancy Hypertension. vol. 3 (2).
- (2013) Feasibility of MR Metabolomics for Immediate Analysis of Resection Margins during Breast Cancer Surgery. PLOS ONE. vol. 8 (4).
- (2013) 2-hydroxyglutarate as a magnetic resonance biomarker for glioma subtyping. Translational Oncology. vol. 6 (2).
- (2013) Spermine and Citrate as Metabolic Biomarkers for Assessing Prostate Cancer Aggressiveness. PLOS ONE. vol. 8 (4).
- (2013) Metabolic changes in psoriatic skin under topical corticosteroid treatment. BMC Dermatology. vol. 13.
- (2013) Metabolic profiles of brain metastases. International Journal of Molecular Sciences. vol. 14 (1).
- (2013) Differentiating diffuse World Health Organization grade II and IV astrocytomas with ex vivo magnetic resonance spectroscopy. Neurosurgery. vol. 72 (2).
- (2013) Proton magnetic resonance metabolomic characterization of ovarian serous carcinoma effusions: chemotherapy-related effects and comparison with malignant mesothelioma and breast carcinoma. Human Pathology. vol. 44 (9).
2012
- (2012) In vivo MRI and histopathological assessment of tumor microenvironment in luminal-like and basal-like breast cancer xenografts. Journal of Magnetic Resonance Imaging. vol. 35 (5).
- (2012) Serum Levels of Choline-Containing Compounds Are Associated with Aerobic Fitness Level: The HUNT-Study. PLOS ONE. vol. 7 (7).
- (2012) Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy. BMC Cancer. vol. 12.
- (2012) Predicting long-term survival and treatment response in breast cancer patients receiving neoadjuvant chemotherapy by MR metabolic profiling. NMR in Biomedicine. vol. 25 (2).
- (2012) Lactate and glycine-potential MR biomarkers of prognosis in estrogen receptor-positive breast cancers. NMR in Biomedicine. vol. 25 (11).
- (2012) Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. vol. 109 (38).
2011
- (2011) In vivo MRS of locally advanced breast cancer: characteristics related to negative or positive choline detection and early monitoring of treatment response. Magnetic Resonance Materials in Physics, Biology and Medicine. vol. 24 (6).
- (2011) Monitoring Neoadjuvant Chemotherapy in Breast Cancer Patients: Improved MR Assessment at 3 T?. Journal of Magnetic Resonance Imaging. vol. 34 (3).
- (2011) Diffusion-Weighted and Dynamic Contrast-Enhanced MRI in Evaluation of Early Treatment Effects During Neoadjuvant Chemotherapy in Breast Cancer Patients. Journal of Magnetic Resonance Imaging. vol. 34 (5).
- (2011) HR MAS MR Spectroscopy in Metabolic Characterization of Cancer. Current Topics in Medicinal Chemistry. vol. 11 (1).
2010
- (2010) Magnetic Resonance Metabolomics of Intact Tissue: A Biotechnological Tool in Cancer Diagnostics and Treatment Evaluation. Cancer Research. vol. 70 (17).
- (2010) Merging transcriptomics and metabolomics - advances in breast cancer profiling. BMC Cancer. vol. 10.
- (2010) Alignment of high resolution magic angle spinning magnetic resonance spectra using warping methods. Analytica Chimica Acta. vol. 683 (1).
- (2010) Multivariate modeling and prediction of breast cancer prognostic factors using MR metabolomics. Journal of Proteome Research. vol. 9 (2).
- (2010) Prognostic value of pretreatment dynamic contrast-enhanced MR imaging in breast cancer patients receiving neoadjuvant chemotherapy: Overall survival predicted from combined time course and volume analysis. Acta Radiologica. vol. 51 (6).
- (2010) Monitoring the Effect of Docetaxel Treatment in MCF7 Xenografts Using Multimodal In Vivo and Ex Vivo Magnetic Resonance Methods, Histopathology and Gene Expression. Translational Oncology. vol. 3 (4).
- (2010) Assessment of early docetaxel response in an experimental model of human breast cancer using DCE-MRI, ex vivo HR MAS, and in vivo 1H MRS. NMR in Biomedicine. vol. 23 (1).
- (2010) Quantification of metabolites in breast cancer patients with different clinical prognosis using HR MAS MR spectroscopy. NMR in Biomedicine. vol. 23 (4).
- (2010) Discrimination of Patients with Microsatellite Instability Colon Cancer using H-1 HR MAS MR Spectroscopy and Chemometric Analysis. Journal of Proteome Research. vol. 9 (7).
2009
- (2009) Combining clinical assessment scores and in vivo MR spectroscopy neurometabolites in very low birth weight adolescents. Artificial Intelligence in Medicine. vol. 47 (2).
- (2009) Predicting Survival and Early Clinical Response to Primary Chemotherapy for Patients With Locally Advanced Breast Cancer Using DCE-MRI. Journal of Magnetic Resonance Imaging. vol. 29 (6).
- (2009) High-resolution MAS MRS of breast cancer biopsies - different approaches. European Radiology. vol. 19.
- (2009) High-resolution magic angle spinning (HR MAS) MR spectroscopy in metabolic characterization of human cancer. Progress in nuclear magnetic resonance spectroscopy. vol. 54 (3-4).
2008
- (2008) Omega-3 Fatty Acids Supress Growth of SW620 Human Colon Cancer Xenografts in Nude Mice. Anticancer Research. vol. 28 (6A).
- (2008) Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy. Molecular Cancer. vol. 7.
- (2008) Characterization of brain metastases using high-resolution magic angle spinning MRS. NMR in Biomedicine. vol. 21.