Bakgrunn og aktiviteter
Prof. Duan Chen (Dr. Med.) er forskningsgruppeleder i forskningsgruppen for eksperimentell kirurgi ved Institutt for klinisk og molekylær medisin (IKOM) ved det medisinske fakultet, NTNU. Han ble uteksaminert fra Lunds universitet i Sverige, er professor ved NTNU og medlemmer i Norges Tekniske Vitenskapsakademi og det Kongelige Norske Videnskabers Selskabs Akademi. Han var president for gastrointestinal seksjon i International Union of Basic and Clinical Pharmacology (IUPHAR), og var leder for en arbeidspakke i EU-prosjektet “Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health” i det 7. europeiske rammeprogrammet.
Vennligst se lenkene under for flere detaljer om hans forskning
http://www.ntnu.no/dmf/ikm/molbiol
http://www.ntnu.no/dmf/ikm/eksperimentell-kirurgi
http://www.ntnu.no/dmf/ikm/eksperimentell_pagaende-forskning
Vitenskapelig, faglig og kunstnerisk arbeid
Et utvalg av nyere tidsskriftspublikasjoner, kunstneriske produksjoner, bok, inklusiv bokdeler og rapport-del. Se alle publikasjoner i databasen
Tidsskriftspublikasjoner
- (2019) PYY plays a key role in the resolution of diabetes following bariatric surgery in humans. EBioMedicine.
- (2018) Innervating Prostate Cancer. New England Journal of Medicine. vol. 378 (7).
- (2018) Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY. Diabetes, obesity and metabolism. vol. 20 (3).
- (2018) New approaches for weight loss: Experiments using animal models. Current pharmaceutical design. vol. 24 (18).
- (2018) 390 - A New Treatment for Pancreatic Cancer: Targeting Nervecancer Cell Crosstalk. Gastroenterology. vol. 154.
- (2017) Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling. Cancer Cell. vol. 31 (1).
- (2017) Time-restricted feeding on weekdays restricts weight gain: A study using rat models of high-fat diet-induced obesity. Physiology and Behavior. vol. 173.
- (2016) A Potential New Regimen (“Tricyclie”) for Treatment of Gastric Cancer: Targeting Glutamine-Dependent Wnt/β-Catenin-mTOR Signaling. Gastroenterology. vol. 150 (4).
- (2016) Intragastric Injection of Botulinum Toxin a to Treat Obesity: Mechanism of Action and a Randomized, Double-Blind, Placebo-Controlled Phase II Trial With Open-Label Extension Study. Gastroenterology. vol. 150 (4).
- (2016) Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. Nature Communications. vol. 7 (10517).
- (2016) Vagal blocking for obesity control: a possible mechanism-of-action. Obesity Surgery. vol. 27 (1).
- (2016) Steady-state energy balance in animal models of obesity and weight loss. Scandinavian Journal of Gastroenterology. vol. 52 (4).
- (2016) Vagotomy and gastric tumorigenesis. Current Neuropharmacology. vol. 14 (8).
- (2016) PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery. Cell reports. vol. 15 (5).
- (2016) Roux-En-Y Gastric Bypass Surgery Restores Impaired Islet Architecture and Function in Type-2 Diabetes by Elevation of Plasma PYY. Gastroenterology. vol. 150 (4).
- (2016) Possible mechanism-of-action of naturally occurring isothiocyanates in chemoprevention and adjuvant chemotherapy for gastric cancer. Gastroenterology.
- (2015) 565Glutamine Metabolism As a Therapeutic Target for Gastric Cancer: Effects of Vagotomy Gastroenterology,Volume 148, Issue 4, Supplement 1, April 2015, Pages S-565–S-566. Gastroenterology. vol. 148 (4).
- (2015) Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjectshypergastrinaemia in healthy subjects. British Journal of Clinical Pharmacology. vol. 79 (5).
- (2015) NGF Promotes Gastrointestinal Cancer Development Through Tumor-Associated Neurogenesis. Gastroenterology. vol. 148 (4).
- (2015) CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis. Gut. vol. 64 (4).