Bodil Merete Kavli
Om
DNA reparasjon og adaptiv immunitet
Hvordan dannes og hvordan repareres skader i arvestoffet vårt? Hvordan benytter immunforsvaret samme molekylære mekanismer for å generere antistoffer til bekjempelse av infeksjon? Hva går galt når friske celler akkumulerer mutasjoner og omdannes til kreftceller? Dette er viktige spørsmål i min forskning.
Sentralt i forskningen er DNA-skaden uracil. I motsetning til i RNA, er ikke uracil en normal base i DNA, men dannes ved spontan eller enzymatisk fjerning av aminogruppen på cytosin. Alle levende organismer har enzymer som kan fjerne uracil fra DNA, såkalte uracil-DNA glycosylaser. Disse er viktige for å forhindre mutasjoner. Karakterisering av disse enzymene har blant annet resultert i den første publiserte proteinstrukturen til et DNA-reparasjonsenzym fra menneske. I tillegg la det grunnlag for den molekylære forståelsen av hvordan et enzym kan gjenkjenne og dytte ut en modifisert base bland alle de normale basene i DNA helixen.
I den senere tid har det blitt klart at immunforsvaret benytter seg av enzymer som spesifikt introduserer uracil i DNA (DNA deaminaser). Dette benyttes både for å inaktivere virus DNA (APOBEC enzymer) og for å generere nye antistoffer ved somatisk hypermutasjon (SHM) og klasse switch rekombinasjon (CSR). I aktiverte B-celler utrykkes activation-induced cytidine deaminase (AID). AID deaminerer cytosin til uracil i immunoglobulin (Ig) genene, noe som initierer både SHM og CSR. Uracil-DNA glycosylase er også sentrale for disse nøkkelprosessene i vårt adaptive immunforsvar.
AID er et mutatorprotein som er veldig sentralt i utviklingen av blant annet B-celle lymfom. Uregulert AID aktivitet kan også mutere gener som er viktige ved utvikling av kreft. I den senere tid har regulering av AID og AID-generert genomisk uracil i forhold til genomstabilitet og utvikling av kreft vært mitt viktigste forskningsfokus.
Publikasjoner
2025
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Iveland, Tobias Solli;
Hagen, Lars;
Sousa, Mirta;
Liabakk, Nina-Beate;
Aas, Per Arne;
Sharma, Animesh;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2025)
Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA.
Scientific Reports
Vitenskapelig artikkel
2023
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Hayran , Abdul Baset ;
Liabakk, Nina-Beate;
Aas, Per Arne;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Sarno, Antonio;
Iveland, Tobias Solli;
Chawla, Konika;
Zahn, Astrid;
DiNoia, Javier M.
(2023)
RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2022
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Halsne, Ruth;
Kavli, Bodil Merete.
(2022)
Cellers replikasjon påvirker translokasjon av DNA.
Tidsskrift for Den norske legeforening (Tidsskriftet)
Fagartikkel
2021
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Kavli, Bodil Merete;
Iveland, Tobias Solli;
Buchinger, Edith;
Hagen, Lars;
Liabakk, Nina-Beate;
Aas, Per Arne;
Obermann, Tobias Sebastian;
Aachmann, Finn Lillelund;
Slupphaug, Geir.
(2021)
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2020
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Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2020)
Genomic Uracil in Biology, Immunity and Cancer.
Vitenskapelig kapittel
2019
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Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars;
Sousa, Mirta;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2018
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Krokan, Hans Einar;
Kavli, Bodil Merete;
Sarno, Antonio;
Slupphaug, Geir.
(2018)
Enzymology of Genomic Uracil Repair.
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir;
Drabløs, Finn.
(2018)
The Earth, Life and Genomic Uracil.
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
DNA Repair is Integrated with Many Cellular Processes.
Faglig kapittel
-
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Genomic Uracil and Immunity.
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Viral Uracil - Uracil DNA glycosylases and dUTPases.
Faglig kapittel
-
Slupphaug, Geir;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2018)
Routes to Uracil in DNA.
Faglig kapittel
-
Sarno, Antonio;
Sætrom, Pål;
Kavli, Bodil Merete;
Pettersen, Henrik Sahlin.
(2018)
Genomic Uracil and Cancer.
Faglig kapittel
-
Dewan, Alisa Elinsdatter;
Xing, Mengtan;
Lundbæk, Marie Benner;
Gago-Fuentes, Raquel;
Beck, Carole;
Aas, Per Arne;
Liabakk, Nina-Beate;
Sæterstad, Siri;
Chau, Khac Thanh Phong;
Kavli, Bodil Merete.
(2018)
Robust DNA repair in PAXX-deficient mammalian cells.
FEBS Open Bio
Vitenskapelig artikkel
2017
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Krokan, Hans Einar;
Slupphaug, Geir;
Kavli, Bodil Merete.
(2017)
Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig kapittel
-
Buchinger, Edith;
Wiik, Siv Åshild;
Kusnierczyk, Anna;
Rabe, Renana;
Aas, Per Arne;
Kavli, Bodil Merete;
Slupphaug, Geir;
Aachmann, Finn Lillelund.
(2017)
Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2.
Biomolecular NMR Assignments
Vitenskapelig artikkel
2015
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Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild;
Aas, Per Arne;
Liabakk, Nina-Beate;
Slupphaug, Geir;
Sætrom, Pål.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
2014
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Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Vitenskapelig artikkel
-
Wallenius, Anders;
Hauser, Jannek;
Aas, Per Arne;
Sarno, Antonio;
Kavli, Bodil Merete;
Krokan, Hans Einar;
Grundström, Thomas.
(2014)
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Molecular Immunology
Vitenskapelig artikkel
-
Hu, Yi;
Ericsson, Ida;
Doseth, Berit;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2014)
Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors.
Experimental Cell Research
Vitenskapelig artikkel
2013
-
Hu, Yi;
Ericsson, Ida;
Torseth, Kathrin;
Methot, Stephen;
Sundheim, Ottar;
Liabakk, Nina-Beate;
Slupphaug, Geir;
Noia, Javier Di;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2013)
A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.
Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Ericsson, Ida;
Galashevskaya, Anastasia;
Sarno, Antonio;
Aas, Per Arne;
Vagbo, CB;
Pettersen, Henrik P Sahlin;
Slupphaug, Geir.
(2013)
Genomic uracil - potent mutagen but normal intermediate in adaptive immunity.
The FEBS Journal
Konferanseabstract
2012
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Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi;
Durandy, Anne;
Otterlei, Marit;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Vitenskapelig artikkel
-
Doseth, Berit;
Ekre, Cecilie;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2012)
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
DNA Repair
Vitenskapelig artikkel
2011
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Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Doseth, Berit;
Visnes, Torkild;
Wallenius, Anders;
Ericsson, Ida;
Sarno, Antonio;
Pettersen, Henrik Sahlin;
Flatberg, Arnar;
Catterall, Tara Cherie;
Slupphaug, Geir;
Krokan, Hans Einar.
(2011)
Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE.
Journal of Biological Chemistry
Vitenskapelig artikkel
2010
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Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Konferanseabstract
2009
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Patenaude, AM;
Orthwein, A;
Hu, Yi;
Campo, VA;
Kavli, Bodil Merete;
Buschiazzo, A;
Noia, JM Di.
(2009)
Active nuclear import and cytoplasmic retention of activation-induced deaminase.
Nature Structural & Molecular Biology
Vitenskapelig artikkel
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour;
Otterlei, Marit;
Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel
2008
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Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete;
Hagen, Lars;
Sundheim, Ottar;
Akbari, Mansour;
Liabakk, Nina-Beate.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar;
Diaz, Javier Pena;
Otterlei, Marit;
Hørning, Ole;
Jensen, Ole N.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
2007
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Hagen, Lars;
Otterlei, Marit;
Gilljam, Karin Margaretha;
Slupphaug, Geir.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Konferanseabstract
-
Parsons, Jason L.;
Kavli, Bodil Merete;
Slupphaug, Geir;
Dianov, Grigory L..
(2007)
NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break.
Biochemistry
Vitenskapelig artikkel
-
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Gilljam, Karin Margaretha;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2007)
Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2006
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Vitenskapelig oversiktsartikkel
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene;
Aarset, Harald;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Konferanseabstract
2005
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A;
Durandy, A;
Krokan, Hans Einar;
Slupphaug, Geir.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
-
Zeitlin, SG;
Patel, S;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2005)
Xenopus CENP - A assembly into chromatin requires base excision repair proteins.
DNA Repair
Vitenskapelig artikkel
2004
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Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate;
Hagen, Lars;
Imai, K;
Durandy, A;
Slupphaug, Geir.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud;
Diaz, Javier Pena;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel
2003
-
Slupphaug, Geir;
Kavli, Bodil;
Krokan, Hans Einar.
(2003)
Interacting pathways that prevent and repair oxidative DNA damage.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Imai, K;
Slupphaug, Geir;
Lee, W-I;
Revy, P;
Nonoyama, S;
Catalan, N;
Yel, L;
Forveille, M;
Kavli, Bodil;
Krokan, Hans Einar.
(2003)
Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch.
Nature Immunology
Vitenskapelig artikkel
-
Scaramozzino, N;
Sanz, G;
Crance, J.M;
Saparbaev, M;
Drillien, R;
Laval, J;
Kavli, Bodil;
Garin, D.
(2003)
Characterisation of the substrate specificity of homogeneous vaccinia virus uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2002
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Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank;
Aas, Per Arne;
Hagen, Lars;
Krokan, Hans Einar;
Slupphaug, Geir.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
2001
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja;
Skjelbred, Camilla Furu;
Akbari, Mansour;
Aas, Per Arne;
Slupphaug, Geir.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
-
Kavli, Bodil.
(2001)
Human uracil-DNA glycosylases from the UNG gene: Structural basis for substrate spesificity and repair.
NTNU, Trondheim
Doktoravhandling
2000
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
1999
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Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde;
Skjelbred, Camilla;
Kavli, Bodil;
Standal, Rune;
Slupphaug, Geir.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
1998
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Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde;
Hernes, T Nagelhus-;
Haug, T;
Aas, Per A;
Akbari, M.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
Plenum Press
Faglig monografi
1996
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Slupphaug, Geir;
Mol, Clifford D.;
Kavli, Bodil;
Arvai, Andrew S.;
Krokan, Hans Einar;
Tainer, John A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Kavli, Bodil;
Slupphaug, Geir;
Mol, Clifford D.;
Arvai, Andrew S.;
Petersen, Steffen B.;
Tainer, John A.;
Krokan, Hans Einar.
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Kavli, B.;
Slupphaug, Geir;
Mol, C.D.;
Arvai, A.S.;
Petersen, S.B.;
Tainer, J.A.;
Krokan, Hans Einar.
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Slupphaug, Geir;
Kavli, B.;
Mol, C.D.;
Arvai, A.;
Krokan, Hans Einar;
Tainer, J.A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
1995
-
Slupphaug, Geir;
Eftedal, Ingrid;
Kavli, Bodil;
Bharati, Sangeeta;
Helle, Nils M;
Haug, Terje;
Levine, David William;
Krokan, Hans Einar.
(1995)
Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.
Biochemistry
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Hu, Yi;
Ericsson, Ida;
Torseth, Kathrin;
Methot, Stephen;
Sundheim, Ottar;
Liabakk, Nina-Beate;
Slupphaug, Geir;
Noia, Javier Di;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2013)
A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.
Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja;
Skjelbred, Camilla Furu;
Akbari, Mansour;
Aas, Per Arne;
Slupphaug, Geir.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete;
Hagen, Lars;
Sundheim, Ottar;
Akbari, Mansour;
Liabakk, Nina-Beate.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Iveland, Tobias Solli;
Buchinger, Edith;
Hagen, Lars;
Liabakk, Nina-Beate;
Aas, Per Arne;
Obermann, Tobias Sebastian;
Aachmann, Finn Lillelund;
Slupphaug, Geir.
(2021)
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Slupphaug, Geir;
Eftedal, Ingrid;
Kavli, Bodil;
Bharati, Sangeeta;
Helle, Nils M;
Haug, Terje;
Levine, David William;
Krokan, Hans Einar.
(1995)
Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.
Biochemistry
Vitenskapelig artikkel
-
Patenaude, AM;
Orthwein, A;
Hu, Yi;
Campo, VA;
Kavli, Bodil Merete;
Buschiazzo, A;
Noia, JM Di.
(2009)
Active nuclear import and cytoplasmic retention of activation-induced deaminase.
Nature Structural & Molecular Biology
Vitenskapelig artikkel
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Vitenskapelig oversiktsartikkel
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Hagen, Lars;
Otterlei, Marit;
Gilljam, Karin Margaretha;
Slupphaug, Geir.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Konferanseabstract
-
Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars;
Sousa, Mirta;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Parsons, Jason L.;
Kavli, Bodil Merete;
Slupphaug, Geir;
Dianov, Grigory L..
(2007)
NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break.
Biochemistry
Vitenskapelig artikkel
-
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Gilljam, Karin Margaretha;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2007)
Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde;
Skjelbred, Camilla;
Kavli, Bodil;
Standal, Rune;
Slupphaug, Geir.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
-
Slupphaug, Geir;
Mol, Clifford D.;
Kavli, Bodil;
Arvai, Andrew S.;
Krokan, Hans Einar;
Tainer, John A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Hayran , Abdul Baset ;
Liabakk, Nina-Beate;
Aas, Per Arne;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Sarno, Antonio;
Iveland, Tobias Solli;
Chawla, Konika;
Zahn, Astrid;
DiNoia, Javier M.
(2023)
RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Kavli, Bodil;
Slupphaug, Geir;
Mol, Clifford D.;
Arvai, Andrew S.;
Petersen, Steffen B.;
Tainer, John A.;
Krokan, Hans Einar.
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Dewan, Alisa Elinsdatter;
Xing, Mengtan;
Lundbæk, Marie Benner;
Gago-Fuentes, Raquel;
Beck, Carole;
Aas, Per Arne;
Liabakk, Nina-Beate;
Sæterstad, Siri;
Chau, Khac Thanh Phong;
Kavli, Bodil Merete.
(2018)
Robust DNA repair in PAXX-deficient mammalian cells.
FEBS Open Bio
Vitenskapelig artikkel
-
Iveland, Tobias Solli;
Hagen, Lars;
Sousa, Mirta;
Liabakk, Nina-Beate;
Aas, Per Arne;
Sharma, Animesh;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2025)
Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA.
Scientific Reports
Vitenskapelig artikkel
-
Buchinger, Edith;
Wiik, Siv Åshild;
Kusnierczyk, Anna;
Rabe, Renana;
Aas, Per Arne;
Kavli, Bodil Merete;
Slupphaug, Geir;
Aachmann, Finn Lillelund.
(2017)
Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2.
Biomolecular NMR Assignments
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate;
Hagen, Lars;
Imai, K;
Durandy, A;
Slupphaug, Geir.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild;
Aas, Per Arne;
Liabakk, Nina-Beate;
Slupphaug, Geir;
Sætrom, Pål.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Ericsson, Ida;
Galashevskaya, Anastasia;
Sarno, Antonio;
Aas, Per Arne;
Vagbo, CB;
Pettersen, Henrik P Sahlin;
Slupphaug, Geir.
(2013)
Genomic uracil - potent mutagen but normal intermediate in adaptive immunity.
The FEBS Journal
Konferanseabstract
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene;
Aarset, Harald;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Konferanseabstract
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A;
Durandy, A;
Krokan, Hans Einar;
Slupphaug, Geir.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud;
Diaz, Javier Pena;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel
-
Slupphaug, Geir;
Kavli, Bodil;
Krokan, Hans Einar.
(2003)
Interacting pathways that prevent and repair oxidative DNA damage.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Imai, K;
Slupphaug, Geir;
Lee, W-I;
Revy, P;
Nonoyama, S;
Catalan, N;
Yel, L;
Forveille, M;
Kavli, Bodil;
Krokan, Hans Einar.
(2003)
Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch.
Nature Immunology
Vitenskapelig artikkel
-
Scaramozzino, N;
Sanz, G;
Crance, J.M;
Saparbaev, M;
Drillien, R;
Laval, J;
Kavli, Bodil;
Garin, D.
(2003)
Characterisation of the substrate specificity of homogeneous vaccinia virus uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Zeitlin, SG;
Patel, S;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2005)
Xenopus CENP - A assembly into chromatin requires base excision repair proteins.
DNA Repair
Vitenskapelig artikkel
-
Doseth, Berit;
Visnes, Torkild;
Wallenius, Anders;
Ericsson, Ida;
Sarno, Antonio;
Pettersen, Henrik Sahlin;
Flatberg, Arnar;
Catterall, Tara Cherie;
Slupphaug, Geir;
Krokan, Hans Einar.
(2011)
Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi;
Durandy, Anne;
Otterlei, Marit;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Vitenskapelig artikkel
-
Doseth, Berit;
Ekre, Cecilie;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2012)
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Konferanseabstract
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar;
Diaz, Javier Pena;
Otterlei, Marit;
Hørning, Ole;
Jensen, Ole N.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
-
Kavli, B.;
Slupphaug, Geir;
Mol, C.D.;
Arvai, A.S.;
Petersen, S.B.;
Tainer, J.A.;
Krokan, Hans Einar.
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Slupphaug, Geir;
Kavli, B.;
Mol, C.D.;
Arvai, A.;
Krokan, Hans Einar;
Tainer, J.A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Wallenius, Anders;
Hauser, Jannek;
Aas, Per Arne;
Sarno, Antonio;
Kavli, Bodil Merete;
Krokan, Hans Einar;
Grundström, Thomas.
(2014)
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Molecular Immunology
Vitenskapelig artikkel
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank;
Aas, Per Arne;
Hagen, Lars;
Krokan, Hans Einar;
Slupphaug, Geir.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Hu, Yi;
Ericsson, Ida;
Doseth, Berit;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2014)
Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors.
Experimental Cell Research
Vitenskapelig artikkel
-
Halsne, Ruth;
Kavli, Bodil Merete.
(2022)
Cellers replikasjon påvirker translokasjon av DNA.
Tidsskrift for Den norske legeforening (Tidsskriftet)
Fagartikkel
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour;
Otterlei, Marit;
Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel
Bøker
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde;
Hernes, T Nagelhus-;
Haug, T;
Aas, Per A;
Akbari, M.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
Plenum Press
Faglig monografi
Del av bok/rapport
-
Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2020)
Genomic Uracil in Biology, Immunity and Cancer.
Vitenskapelig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Sarno, Antonio;
Slupphaug, Geir.
(2018)
Enzymology of Genomic Uracil Repair.
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir;
Drabløs, Finn.
(2018)
The Earth, Life and Genomic Uracil.
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
DNA Repair is Integrated with Many Cellular Processes.
Faglig kapittel
-
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Genomic Uracil and Immunity.
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Viral Uracil - Uracil DNA glycosylases and dUTPases.
Faglig kapittel
-
Slupphaug, Geir;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2018)
Routes to Uracil in DNA.
Faglig kapittel
-
Krokan, Hans Einar;
Slupphaug, Geir;
Kavli, Bodil Merete.
(2017)
Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig kapittel
-
Sarno, Antonio;
Sætrom, Pål;
Kavli, Bodil Merete;
Pettersen, Henrik Sahlin.
(2018)
Genomic Uracil and Cancer.
Faglig kapittel
Studentoppgave eller avhandling
-
Kavli, Bodil.
(2001)
Human uracil-DNA glycosylases from the UNG gene: Structural basis for substrate spesificity and repair.
NTNU, Trondheim
Doktoravhandling
Undervisning
Emner
Formidling
UNG in antibody class switching and uracil repair – How to be in the right place at the right time
2025
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KonferanseforedragKavli, Bodil Merete. (2025) UNG in antibody class switching and uracil repair – How to be in the right place at the right time. 8th EU-US Conference on Endogenous DNA Damage and Repair
2023
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KonferanseforedragKavli, Bodil Merete. (2023) Uracil-DNA glycosylase(UNG)-one enzyme-many functions ...how to be in the right place at the right time…. Monday meeting - Untit of Labarotory Mediscine
2021
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KonferanseforedragKavli, Bodil Merete. (2021) How to repair DNA lesions in single stranded DNA at the replication fork. Mandagsforedrag - Faggruppe for laboratoriemedisin
2019
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KonferanseforedragKavli, Bodil Merete. (2019) Identification of novel biomarkers in B-cell lymphomas. Workshop LABMED: From basic to translational research
2018
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ForedragKavli, Bodil Merete. (2018) Cytidin deaminaser - Sentrale aktører i immunforsvaret, men også en viktig kilde til mutasjoner og kreft. Prøveforelesning for professorat
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ForedragKavli, Bodil Merete. (2018) DNA repair, adaptive immunity and B-cell lymphoma - Its all about genomic uracil.... Seminar Faggruppe for Laboratoriemedisin
2017
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Konferanseforedrag
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KonferanseforedragKavli, Bodil Merete. (2017) DNA repair, adaptive immunity and B-cell lymphoma. Trondheim-Oslo Genome Dynamics Workkshop
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KonferanseposterLundbæk, Marie Benner; Sarno, Antonio; Liabakk, Nina-Beate; Aas, Per Arne; Krokan, Hans Einar; Kavli, Bodil Merete. (2017) Mitochondrial uracil-DNA glycosylase UNG1 supports class switch recombination and genomic uracil processing in mouse B-cell. B-cells and T Follicular Helper cells: Controling Long-Lived Immunity
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ForedragKavli, Bodil Merete. (2017) DNA-reparasjon og immunforsvar - Hva er sammenhengen?. Møte i Det Kongelige Norske Videnskapers Selskabs Akademi
2016
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KonferanseforedragKrokan, Hans Einar; Kavli, Bodil Merete; Pettersen, Henrik Sahlin; Sætrom, Pål; Galashevskaya, Anastasia; Sarno, Antonio; Aas, Per Arne; Doseth, Berit; Slupphaug, Geir. (2016) Genomic Uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan
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KonferanseforedragKavli, Bodil Merete; Pettersen, Henrik Sahlin; Ericsson, Ida; Hu, Yi; Krokan, Hans Einar. (2016) AID og genomisk uracil; kilde til mutasjoner og utvikling av B-celle lymphom. Onkologisk forum 2016
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KonferanseforedragKavli, Bodil Merete; Lundbæk, Marie Benner; Sarno, Antonio; Liabakk, Nina-Beate. (2016) New results and ongoing research related to deaminases. 1st DeamiNET meeting
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KonferanseforedragLundbæk, Marie Benner; Sarno, Antonio; Liabakk, Nina-Beate; Krokan, Hans Einar; Kavli, Bodil Merete. (2016) Mitochondrial UNG1 supports class switch recombination in mouse B-cells. 10th 3R International Symposium
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KonferanseforedragKrokan, Hans Einar; Pettersen, Henrik Sahlin; Mjelle, Robin; Hegre, Siv Anita; Sætrom, Pål; Drabløs, Finn Sverre; Sarno, Antonio; Galashevskaya, Anastasia; Aas, Per Arne; Liabakk, Nina-Beate. (2016) REGULATION OF BASE EXCISION REPAIR – CANONICAL AND NON-CANONICAL PROCESSING OF GENOMIC URACIL. 10th International Multiconference on Bioinformatics of Genome Regulation and Structure\Systems Biology
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KonferanseforedragKrokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2016) DNA Repair in diagnosis and therapy of cancer - opportunities and problems. 1st International NTNU Symposium on Clinical Biomarkers of Cancer
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ForedragKrokan, Hans Einar; Slupphaug, Geir; Sætrom, Pål; Sarno, Antonio; Galashevskaya, Anastasia; Lundbæk, Marie Benner; Aas, Per Arne; Krokan, Ruth Haaland; Liabakk, Nina-Beate; Pettersen, Henrik Sahlin. (2016) Genomic uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. Eurotox 2016
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ForedragKavli, Bodil Merete. (2016) Genomic uracil - General mutagic DNA lesion and Specific intermediate in immunity. 1st minisymposium "DNA repair, Epigenetics and Traslational medicine"
2015
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KonferanseforedragKavli, Bodil Merete. (2015) AID and BER enzymes in Adaptive Immunity and Genomic Integrity. Genomic Interity Conference 2015
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KonferanseforedragKavli, Bodil Merete. (2015) Activation-induced cytidine deaminase and base excision repair in adaptive immunity. Onsdagsmøte IKM
2014
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ForedragKavli, Bodil Merete. (2014) Identification of the AID interactome. Gruppemøte, Faggruppe for molekylærbiologi
2013
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KonferanseforedragKavli, Bodil Merete. (2013) "Nuclear Import Rate and Deaminase Activity of AID Control Ig Class Switching". Onsdagseminar
2012
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Konferanseforedrag
2011
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KonferanseposterPettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. 4th EU-USA conference on DNA base damage and repair
2010
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KonferanseforedragHagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Slupphaug, Geir. (2010) Post translational modifications of the human DNA repair protein uracil DNA glycosylase, UNG2. 6th Norwegian National Proteomics Meeting
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KonferanseforedragKavli, Bodil Merete. (2010) Ervervet immunitet- nødvendig for overlevelse, men med risiko for kreft. Fagdagene, åpning av nytt sykehus, St Olav
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Intervju
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KonferanseforedragKavli, Bodil Merete. (2010) Adaptive immunity - Essential for survival, but with risk for cancer. onsdagsmøte -IKM
2009
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KonferanseposterSahlin, Pettersen Henrik; Visnes, Torkild; Vågbø, Cathrine Broberg; Kavli, Bodil Merete; Krokan, Hans Einar. (2009) Cytotoxicity of 5-fluorouracil is mainly due to RNA effects and thymidylate synthase inhibition, not excessive DNA repair. 2nd Erling Seeberg Symposium on DNA Repair
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KonferanseforedragSlupphaug, Geir; Doseth, Berit; Kavli, Bodil Merete; Visnes, Torkild; Hagen, Lars; Torseth, Kathrin; Pettersen, Henrik Sahlin; Akbari, Mansour; Otterlei, Marit; Krokan, Hans Einar. (2009) Genomic uracil processing in mice and men. 2.nd Erling Seeberg symposium on DNA repair
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KonferanseforedragHu, Yi; Kavli, Bodil Merete. (2009) The mutator enzyme AID; how is the intracellular localization regulated?. IKM tirsdagsmøte
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KonferanseforedragKrokan, Hans Einar; Visnes, Torkild; Doseth, Berit; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir. (2009) Uracil in DNA and its processing. 3rd US-EU Conference- Repair of Endogenous Genome Damage
2008
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KonferanseforedragSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance
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KonferanseforedragKavli, Bodil Merete. (2008) Two levels of protection for the B cell genome during somatic hypermutation. Mandagsmøte IKM
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ForedragKavli, Bodil Merete. (2008) Uracil i DNA; generelt mutagen og viktig mellomprodukt i adaptiv immunitet. Fagdag i biologi for biologilærere i videregående skole
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ForedragKavli, Bodil Merete. (2008) Uracil i DNA. Foredrag for Bioligistudenter fra Byåsen videregående skole
2007
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KonferanseforedragVisnes, Torkild; Kavli, Bodil Merete; Pettersen, Henrik P Sahlin; Krokan, Hans Einar. (2007) Efficient repair of 5-fluorouracil from DNA by base excision repair: roles of UNG2 and SMUG1. EU - IP DNA Repair workshop for young scientists
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KonferanseforedragKavli, Bodil Merete. (2007) UNG2 and SMUG1 coordinate the initial steps in BER by different mechanisms. Mandagsforedrag IKMM
2006
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KonferanseforedragKavli, Bodil Merete. (2006) Uracil i DNA; Generelt mutagen og viktig intermediat i adaptive immunitet. Gjesteforelesning for elever ved Høyskolen i Oslo
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KonferanseposterHagen, Lars; Kavli, Bodil Merete; Sundheim, Ottar; Sousa, Mirta; Otterlei, Marit; Liabakk, Nina-Beate; Torseth, Kathrin; Krokan, Hans Einar; Slupphaug, Geir. (2006) Regulation of uracil base excision repair by post-translational modifications. Erling Seeberg Symposium on DNA Repair
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Konferanseforedrag
2005
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KonferanseposterKavli, Bodil Merete; Diaz, Javier Pena; Otterlei, Marit; Liabakk, Nina-Beate; Giljam, Karin Margaretha; Krokan, Hans Einar; Hørning, Ole; Jensen, Ole N; Slupphaug, Geir; Hagen, Lars. (2005) The enzymatic activity of human uracil-DNA glycosylase UNG2 is regulated by N-terminal phosphorylation during cell cycle. 2nd EU-US DNA Repair Meeting: Endogeneous Stress, Base excision repair and related processes
2004
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KonferanseposterKavli, Bodil; Otterlei, Marit; Liabakk, Nina-Beate; Krokan, Hans Einar; Slupphaug, Geir. (2004) The mutant UNG2-F-25 1S associated with HIGM syndrome is abnormally translocated and degraded, and results in impaired nuclear uracil excision and accumulation of genomic uracil. ASM Conference on DNA Repair and Mutagenesis
2003
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ForedragKavli, Bodil. (2003) AID og UNG; Nøkkelenzymer i affinitetsmodning av immunoglobuliner og klasse-switch. [Mangler data]
2002
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KonferanseposterKavli, Bodil; Otterlei, Marit; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in uracil-DNA repair in the nucleus. Mutagenesis and Carcinogenesis, Gordon Research Conference
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KonferanseposterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2002) Substrate preference and enzyme kinetics reveal distinct properties of UNG2 and SMUG1 in cellular base-excision repair; hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup. 32nd Annual Meeting of European Environmental Mutagen Society. DNA Damage and Repair Fundamental Aspects and Contribution to Human Disorders
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Konferanseforedrag
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KonferanseposterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Otterlei, Marit; Skorpen, Frank; Krokan, Hans Einar; Slupphaug, Geir. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in DNA-uracil repair in the nucleus. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life
2001
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ForedragKavli, Bodil. (2001) Human uracil DNA glucosylases from UNG-gene. Structural basis for substrate specificity and repair. [Mangler data]
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KonferanseposterSundheim, Ottar; Otterlei, Marit; Kavli, Bodil; Skorpen, Frank; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2001) Structure-function analysis of the human uracil-DNA glycosylase hSMUG1. Sixth International School on the Crystallography of Biological Macromolecules.
2000
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ForedragKrokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Slupphaug, Geir; Barnes, Deborah; Lindahl, Tomas. (2000) Structure-function aspects of human uracil-DNA glycosylase and its interactions with other proteins. DNA Base Excision Repair Workshop (BER 2000 WORKSHOP)
1999
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KonferanseposterKrokan, Hans Einar; Slupphaug, Geir; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank. (1999) Excicion Repar of DNA Damage 1. [Mangler data]
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KonferanseposterOtterlei, Marit; Kavli, B.; Standal, R.; Skjelbred, Camilla; Bharati, S.; Krokan, Hans Einar. (1999) In vivo Repair of AP-sites in the E.coli Chromosome. [Mangler data]
1998
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ForedragKavli, Bodil. (1998) Kartlegging av protein struktur/funksjon vha setespesifikk mutagenese og røntgenkrystallografi. Storlienmøte
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KonferanseposterKavli, Bodil; Otterlei, Marit; Skjelbred, Camilla; Standal, Rune; Bharati, Sangeeta; Krokan, Hans Einar. (1998) Mutation frequency and mutation spectra caused by chromosomal AP-site in repair deficient E.coli strains. Norsk Biokjemisk Selskaps møte