Bodil Merete Kavli
Om
DNA reparasjon og adaptiv immunitet
Hvordan dannes og hvordan repareres skader i arvestoffet vårt? Hvordan benytter immunforsvaret samme molekylære mekanismer for å generere antistoffer til bekjempelse av infeksjon? Hva går galt når friske celler akkumulerer mutasjoner og omdannes til kreftceller? Dette er viktige spørsmål i min forskning.
Sentralt i forskningen er DNA-skaden uracil. I motsetning til i RNA, er ikke uracil en normal base i DNA, men dannes ved spontan eller enzymatisk fjerning av aminogruppen på cytosin. Alle levende organismer har enzymer som kan fjerne uracil fra DNA, såkalte uracil-DNA glycosylaser. Disse er viktige for å forhindre mutasjoner. Karakterisering av disse enzymene har blant annet resultert i den første publiserte proteinstrukturen til et DNA-reparasjonsenzym fra menneske. I tillegg la det grunnlag for den molekylære forståelsen av hvordan et enzym kan gjenkjenne og dytte ut en modifisert base bland alle de normale basene i DNA helixen.
I den senere tid har det blitt klart at immunforsvaret benytter seg av enzymer som spesifikt introduserer uracil i DNA (DNA deaminaser). Dette benyttes både for å inaktivere virus DNA (APOBEC enzymer) og for å generere nye antistoffer ved somatisk hypermutasjon (SHM) og klasse switch rekombinasjon (CSR). I aktiverte B-celler utrykkes activation-induced cytidine deaminase (AID). AID deaminerer cytosin til uracil i immunoglobulin (Ig) genene, noe som initierer både SHM og CSR. Uracil-DNA glycosylase er også sentrale for disse nøkkelprosessene i vårt adaptive immunforsvar.
AID er et mutatorprotein som er veldig sentralt i utviklingen av blant annet B-celle lymfom. Uregulert AID aktivitet kan også mutere gener som er viktige ved utvikling av kreft. I den senere tid har regulering av AID og AID-generert genomisk uracil i forhold til genomstabilitet og utvikling av kreft vært mitt viktigste forskningsfokus.
Publikasjoner
2025
-
Iveland, Tobias Solli;
Hagen, Lars;
Sousa, Mirta;
Liabakk, Nina-Beate;
Aas, Per Arne;
Sharma, Animesh.
(2025)
Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA.
Scientific Reports
Vitenskapelig artikkel
2023
-
Hayran , Abdul Baset ;
Liabakk, Nina-Beate;
Aas, Per Arne;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Sarno, Antonio.
(2023)
RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2022
-
Halsne, Ruth;
Kavli, Bodil Merete.
(2022)
Cellers replikasjon påvirker translokasjon av DNA.
Tidsskrift for Den norske legeforening (Tidsskriftet)
Fagartikkel
2021
-
Kavli, Bodil Merete;
Iveland, Tobias Solli;
Buchinger, Edith;
Hagen, Lars;
Liabakk, Nina-Beate;
Aas, Per Arne.
(2021)
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2020
-
Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2020)
Genomic Uracil in Biology, Immunity and Cancer.
Royal Society of Chemistry (RSC) Publishing
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
2019
-
Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2018
-
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Genomic Uracil and Immunity.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Viral Uracil - Uracil DNA glycosylases and dUTPases.
World Scientific
Faglig kapittel
-
Slupphaug, Geir;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2018)
Routes to Uracil in DNA.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
DNA Repair is Integrated with Many Cellular Processes.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Sarno, Antonio;
Slupphaug, Geir.
(2018)
Enzymology of Genomic Uracil Repair.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir;
Drabløs, Finn.
(2018)
The Earth, Life and Genomic Uracil.
World Scientific
Faglig kapittel
-
Sarno, Antonio;
Sætrom, Pål;
Kavli, Bodil Merete;
Pettersen, Henrik Sahlin.
(2018)
Genomic Uracil and Cancer.
World Scientific
Faglig kapittel
-
Dewan, Alisa Elinsdatter;
Xing, Mengtan;
Lundbæk, Marie Benner;
Gago-Fuentes, Raquel;
Beck, Carole;
Aas, Per Arne.
(2018)
Robust DNA repair in PAXX-deficient mammalian cells.
FEBS Open Bio
Vitenskapelig artikkel
2017
-
Buchinger, Edith;
Wiik, Siv Åshild;
Kusnierczyk, Anna;
Rabe, Renana;
Aas, Per Arne;
Kavli, Bodil Merete.
(2017)
Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2.
Biomolecular NMR Assignments
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Slupphaug, Geir;
Kavli, Bodil Merete.
(2017)
Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
2015
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
2014
-
Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Vitenskapelig artikkel
-
Hu, Yi;
Ericsson, Ida;
Doseth, Berit;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2014)
Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors.
Experimental Cell Research
Vitenskapelig artikkel
-
Wallenius, Anders;
Hauser, Jannek;
Aas, Per Arne;
Sarno, Antonio;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2014)
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Molecular Immunology
Vitenskapelig artikkel
2013
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Ericsson, Ida;
Galashevskaya, Anastasia;
Sarno, Antonio;
Aas, Per Arne.
(2013)
Genomic uracil - potent mutagen but normal intermediate in adaptive immunity.
The FEBS Journal
Sammendrag/abstract
-
Hu, Yi;
Ericsson, Ida;
Torseth, Kathrin;
Methot, Stephen;
Sundheim, Ottar;
Liabakk, Nina-Beate.
(2013)
A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.
Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
2012
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Vitenskapelig artikkel
-
Doseth, Berit;
Ekre, Cecilie;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2012)
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
DNA Repair
Vitenskapelig artikkel
2011
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Doseth, Berit;
Visnes, Torkild;
Wallenius, Anders;
Ericsson, Ida;
Sarno, Antonio;
Pettersen, Henrik Sahlin.
(2011)
Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE.
Journal of Biological Chemistry
Vitenskapelig artikkel
2010
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Sammendrag/abstract
2009
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel/review
-
Patenaude, AM;
Orthwein, A;
Hu, Yi;
Campo, VA;
Kavli, Bodil Merete;
Buschiazzo, A.
(2009)
Active nuclear import and cytoplasmic retention of activation-induced deaminase.
Nature Structural & Molecular Biology
Vitenskapelig artikkel
2008
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
2007
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Sammendrag/abstract
-
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Gilljam, Karin Margaretha;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2007)
Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Vitenskapelig artikkel
-
Parsons, Jason L.;
Kavli, Bodil Merete;
Slupphaug, Geir;
Dianov, Grigory L..
(2007)
NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break.
Biochemistry
Vitenskapelig artikkel
2006
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Vitenskapelig oversiktsartikkel/review
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Sammendrag/abstract
2005
-
Zeitlin, SG;
Patel, S;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2005)
Xenopus CENP - A assembly into chromatin requires base excision repair proteins.
DNA Repair
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
2004
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2003
-
Scaramozzino, N;
Sanz, G;
Crance, J.M;
Saparbaev, M;
Drillien, R;
Laval, J.
(2003)
Characterisation of the substrate specificity of homogeneous vaccinia virus uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Slupphaug, Geir;
Kavli, Bodil;
Krokan, Hans Einar.
(2003)
Interacting pathways that prevent and repair oxidative DNA damage.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Imai, K;
Slupphaug, Geir;
Lee, W-I;
Revy, P;
Nonoyama, S;
Catalan, N.
(2003)
Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch.
Nature Immunology
Vitenskapelig artikkel
2002
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
2001
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
-
Kavli, Bodil.
(2001)
Human uracil-DNA glycosylases from the UNG gene: Structural basis for substrate spesificity and repair.
NTNU, Trondheim
Doktorgradsavhandling
2000
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
1999
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
1998
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences.
Fagbok
1996
-
Slupphaug, Geir;
Kavli, B.;
Mol, C.D.;
Arvai, A.;
Krokan, Hans Einar;
Tainer, J.A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Kavli, B.;
Slupphaug, Geir;
Mol, C.D.;
Arvai, A.S.;
Petersen, S.B.;
Tainer, J.A..
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Kavli, Bodil;
Slupphaug, Geir;
Mol, Clifford D.;
Arvai, Andrew S.;
Petersen, Steffen B.;
Tainer, John A..
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Slupphaug, Geir;
Mol, Clifford D.;
Kavli, Bodil;
Arvai, Andrew S.;
Krokan, Hans Einar;
Tainer, John A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
1995
-
Slupphaug, Geir;
Eftedal, Ingrid;
Kavli, Bodil;
Bharati, Sangeeta;
Helle, Nils M;
Haug, Terje.
(1995)
Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.
Biochemistry
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Iveland, Tobias Solli;
Hagen, Lars;
Sousa, Mirta;
Liabakk, Nina-Beate;
Aas, Per Arne;
Sharma, Animesh.
(2025)
Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA.
Scientific Reports
Vitenskapelig artikkel
-
Hayran , Abdul Baset ;
Liabakk, Nina-Beate;
Aas, Per Arne;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Sarno, Antonio.
(2023)
RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Halsne, Ruth;
Kavli, Bodil Merete.
(2022)
Cellers replikasjon påvirker translokasjon av DNA.
Tidsskrift for Den norske legeforening (Tidsskriftet)
Fagartikkel
-
Kavli, Bodil Merete;
Iveland, Tobias Solli;
Buchinger, Edith;
Hagen, Lars;
Liabakk, Nina-Beate;
Aas, Per Arne.
(2021)
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Dewan, Alisa Elinsdatter;
Xing, Mengtan;
Lundbæk, Marie Benner;
Gago-Fuentes, Raquel;
Beck, Carole;
Aas, Per Arne.
(2018)
Robust DNA repair in PAXX-deficient mammalian cells.
FEBS Open Bio
Vitenskapelig artikkel
-
Buchinger, Edith;
Wiik, Siv Åshild;
Kusnierczyk, Anna;
Rabe, Renana;
Aas, Per Arne;
Kavli, Bodil Merete.
(2017)
Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2.
Biomolecular NMR Assignments
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Vitenskapelig artikkel
-
Hu, Yi;
Ericsson, Ida;
Doseth, Berit;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2014)
Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors.
Experimental Cell Research
Vitenskapelig artikkel
-
Wallenius, Anders;
Hauser, Jannek;
Aas, Per Arne;
Sarno, Antonio;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2014)
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Molecular Immunology
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Ericsson, Ida;
Galashevskaya, Anastasia;
Sarno, Antonio;
Aas, Per Arne.
(2013)
Genomic uracil - potent mutagen but normal intermediate in adaptive immunity.
The FEBS Journal
Sammendrag/abstract
-
Hu, Yi;
Ericsson, Ida;
Torseth, Kathrin;
Methot, Stephen;
Sundheim, Ottar;
Liabakk, Nina-Beate.
(2013)
A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.
Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Vitenskapelig artikkel
-
Doseth, Berit;
Ekre, Cecilie;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2012)
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
DNA Repair
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Doseth, Berit;
Visnes, Torkild;
Wallenius, Anders;
Ericsson, Ida;
Sarno, Antonio;
Pettersen, Henrik Sahlin.
(2011)
Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Sammendrag/abstract
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel/review
-
Patenaude, AM;
Orthwein, A;
Hu, Yi;
Campo, VA;
Kavli, Bodil Merete;
Buschiazzo, A.
(2009)
Active nuclear import and cytoplasmic retention of activation-induced deaminase.
Nature Structural & Molecular Biology
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Sammendrag/abstract
-
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Gilljam, Karin Margaretha;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2007)
Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Vitenskapelig artikkel
-
Parsons, Jason L.;
Kavli, Bodil Merete;
Slupphaug, Geir;
Dianov, Grigory L..
(2007)
NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break.
Biochemistry
Vitenskapelig artikkel
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Vitenskapelig oversiktsartikkel/review
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Sammendrag/abstract
-
Zeitlin, SG;
Patel, S;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2005)
Xenopus CENP - A assembly into chromatin requires base excision repair proteins.
DNA Repair
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Scaramozzino, N;
Sanz, G;
Crance, J.M;
Saparbaev, M;
Drillien, R;
Laval, J.
(2003)
Characterisation of the substrate specificity of homogeneous vaccinia virus uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Slupphaug, Geir;
Kavli, Bodil;
Krokan, Hans Einar.
(2003)
Interacting pathways that prevent and repair oxidative DNA damage.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Imai, K;
Slupphaug, Geir;
Lee, W-I;
Revy, P;
Nonoyama, S;
Catalan, N.
(2003)
Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch.
Nature Immunology
Vitenskapelig artikkel
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
-
Slupphaug, Geir;
Kavli, B.;
Mol, C.D.;
Arvai, A.;
Krokan, Hans Einar;
Tainer, J.A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Kavli, B.;
Slupphaug, Geir;
Mol, C.D.;
Arvai, A.S.;
Petersen, S.B.;
Tainer, J.A..
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Kavli, Bodil;
Slupphaug, Geir;
Mol, Clifford D.;
Arvai, Andrew S.;
Petersen, Steffen B.;
Tainer, John A..
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Slupphaug, Geir;
Mol, Clifford D.;
Kavli, Bodil;
Arvai, Andrew S.;
Krokan, Hans Einar;
Tainer, John A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Slupphaug, Geir;
Eftedal, Ingrid;
Kavli, Bodil;
Bharati, Sangeeta;
Helle, Nils M;
Haug, Terje.
(1995)
Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.
Biochemistry
Vitenskapelig artikkel
Bøker
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences.
Fagbok
Del av bok/rapport
-
Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2020)
Genomic Uracil in Biology, Immunity and Cancer.
Royal Society of Chemistry (RSC) Publishing
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Genomic Uracil and Immunity.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Viral Uracil - Uracil DNA glycosylases and dUTPases.
World Scientific
Faglig kapittel
-
Slupphaug, Geir;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2018)
Routes to Uracil in DNA.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
DNA Repair is Integrated with Many Cellular Processes.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Sarno, Antonio;
Slupphaug, Geir.
(2018)
Enzymology of Genomic Uracil Repair.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir;
Drabløs, Finn.
(2018)
The Earth, Life and Genomic Uracil.
World Scientific
Faglig kapittel
-
Sarno, Antonio;
Sætrom, Pål;
Kavli, Bodil Merete;
Pettersen, Henrik Sahlin.
(2018)
Genomic Uracil and Cancer.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Slupphaug, Geir;
Kavli, Bodil Merete.
(2017)
Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
Rapport
-
Kavli, Bodil.
(2001)
Human uracil-DNA glycosylases from the UNG gene: Structural basis for substrate spesificity and repair.
NTNU, Trondheim
Doktorgradsavhandling
Undervisning
Emner
Formidling
2023
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Vitenskapelig foredragKavli, Bodil Merete. (2023) Uracil-DNA glycosylase(UNG)-one enzyme-many functions ...how to be in the right place at the right time… . IKOM Monday meeting - Untit of Labarotory Mediscine , NTNU-Lab senter 2023-08-21 -
2021
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Vitenskapelig foredragKavli, Bodil Merete. (2021) How to repair DNA lesions in single stranded DNA at the replication fork. Marit Otterlei-IKOM-Faggruppe for laboratoriemedisin-NTNU Mandagsforedrag - Faggruppe for laboratoriemedisin , Trondheim 2021-01-18 - 2021-01-18
2019
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Vitenskapelig foredragKavli, Bodil Merete. (2019) Identification of novel biomarkers in B-cell lymphomas . Fagruppe for laboratoriemedisin Workshop LABMED: From basic to translational research , Trondheim, Laboratoriesenteret Øya 2019-11-11 - 2019-11-11
2018
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Faglig foredragKavli, Bodil Merete. (2018) Cytidin deaminaser - Sentrale aktører i immunforsvaret, men også en viktig kilde til mutasjoner og kreft . NTNU-IKOM Prøveforelesning for professorat 2018-11-26 -
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Faglig foredragKavli, Bodil Merete. (2018) DNA repair, adaptive immunity and B-cell lymphoma - Its all about genomic uracil.... Magnar Bjørås IKOM Seminar Faggruppe for Laboratoriemedisin , NTNU 2018-10-29 -
2017
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Vitenskapelig foredragKavli, Bodil Merete. (2017) DNA repair, adaptive immunity and B-cell lymphoma. Magnar Bjørås Trondheim-Oslo Genome Dynamics Workkshop , Scandic hotel Lerkendal 2017-06-15 - 2017-06-16
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Populærvitenskapelig foredragKavli, Bodil Merete. (2017) DNA-reparasjon og immunforsvar - Hva er sammenhengen?. DKNVS Akademiet Møte i Det Kongelige Norske Videnskapers Selskabs Akademi , DKNVS Elvegata 17, Trondheim 2017-02-06 - 2017-07-06
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PosterLundbæk, Marie Benner; Sarno, Antonio; Liabakk, Nina-Beate; Aas, Per Arne; Krokan, Hans Einar; Kavli, Bodil Merete. (2017) Mitochondrial uracil-DNA glycosylase UNG1 supports class switch recombination and genomic uracil processing in mouse B-cell. Keystone B-cells and T Follicular Helper cells: Controling Long-Lived Immunity , Whistler 2017-04-23 - 2017-04-27
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Vitenskapelig foredragKavli, Bodil Merete. (2017) Genomic Uracil-Introduction and Processing in Immunity. NTNU Unit meeting 2017-03-13 - 2017-03-13
2016
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Vitenskapelig foredragKavli, Bodil Merete; Lundbæk, Marie Benner; Sarno, Antonio; Liabakk, Nina-Beate. (2016) New results and ongoing research related to deaminases. Svend Petersen-Mahrt IFOM 1st DeamiNET meeting , UFOM-Milano 2016-11-10 - 2016-11-11
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Faglig foredragKavli, Bodil Merete. (2016) Genomic uracil - General mutagic DNA lesion and Specific intermediate in immunity. Barbara van Loon 1st minisymposium "DNA repair, Epigenetics and Traslational medicine" , NTNU - kunnskapssenteret 2016-09-22 - 2016-09-23
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Vitenskapelig foredragKrokan, Hans Einar; Kavli, Bodil Merete; Pettersen, Henrik Sahlin; Sætrom, Pål; Galashevskaya, Anastasia; Sarno, Antonio. (2016) Genomic Uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan , Matsue 2016-11-13 - 2016-11-17
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Vitenskapelig foredragKavli, Bodil Merete; Pettersen, Henrik Sahlin; Ericsson, Ida; Hu, Yi; Krokan, Hans Einar. (2016) AID og genomisk uracil; kilde til mutasjoner og utvikling av B-celle lymphom. Onkologisk forum Onkologisk forum 2016 , Scandic hotel- Lerkendal, Trondheim 2016-11-17 - 2016-11-18
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Vitenskapelig foredragLundbæk, Marie Benner; Sarno, Antonio; Liabakk, Nina-Beate; Krokan, Hans Einar; Kavli, Bodil Merete. (2016) Mitochondrial UNG1 supports class switch recombination in mouse B-cells. 10th 3R Symposium Organzing Committee 10th 3R International Symposium , Matsue 2016-11-13 - 2016-11-17
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Vitenskapelig foredragKrokan, Hans Einar; Pettersen, Henrik Sahlin; Mjelle, Robin; Hegre, Siv Anita; Sætrom, Pål; Drabløs, Finn Sverre. (2016) REGULATION OF BASE EXCISION REPAIR – CANONICAL AND NON-CANONICAL PROCESSING OF GENOMIC URACIL. Russian Academy of Sciences, Siberian branch 10th International Multiconference on Bioinformatics of Genome Regulation and Structure\Systems Biology , Akademorodok, Novosibirsk 2016-08-29 - 2016-09-03
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Faglig foredragKrokan, Hans Einar; Slupphaug, Geir; Sætrom, Pål; Sarno, Antonio; Galashevskaya, Anastasia; Lundbæk, Marie Benner. (2016) Genomic uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. Turkish Society of Toxicology. Eurotox 2016 , Sivilla 2016-09-04 -
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Vitenskapelig foredragKrokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2016) DNA Repair in diagnosis and therapy of cancer - opportunities and problems. NTNU 1st International NTNU Symposium on Clinical Biomarkers of Cancer , Trondheim 2016-06-16 - 2016-06-17
2015
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Vitenskapelig foredragKavli, Bodil Merete. (2015) AID and BER enzymes in Adaptive Immunity and Genomic Integrity. Zing Conferences Genomic Interity Conference 2015 , Cairns 2015-08-01 - 2015-08-05
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Vitenskapelig foredragKavli, Bodil Merete. (2015) Activation-induced cytidine deaminase and base excision repair in adaptive immunity. IKM-NTNU Onsdagsmøte IKM , Trondheim 2015-09-02 -
2014
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Faglig foredragKavli, Bodil Merete. (2014) Identification of the AID interactome. Faggruppe for Molekylærbiologi Gruppemøte, Faggruppe for molekylærbiologi , NTNU 2014-10-13 - 2014-10-13
2013
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Vitenskapelig foredragKavli, Bodil Merete. (2013) "Nuclear Import Rate and Deaminase Activity of AID Control Ig Class Switching". IKM Onsdagseminar , NTNU 2013-01-09 -
2012
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Vitenskapelig foredragKavli, Bodil Merete. (2012) "Regulation of AID". Instituttgruppe for molekylærbiologi Mandagsmøte 2012-10-22 -
2011
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PosterPettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. UiO 4th EU-USA conference on DNA base damage and repair , Holmenkollen Park Hotell 2011-05-18 - 2011-05-22
2010
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Vitenskapelig foredragHagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Slupphaug, Geir. (2010) Post translational modifications of the human DNA repair protein uracil DNA glycosylase, UNG2. 6th Norwegian National Proteomics Meeting 2010-12-09 - 2010-12-10
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Vitenskapelig foredragKavli, Bodil Merete. (2010) Adaptive immunity - Essential for survival, but with risk for cancer. Jon lamvik onsdagsmøte -IKM , NTNU 2010-09-29 -
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IntervjuKavli, Bodil Merete. (2010) "Sammenhengen mellom betennelse og kreft". Her og nå, NRK p1 Her og nå, NRK p1 [Radio] 2010-11-01
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Vitenskapelig foredragKavli, Bodil Merete. (2010) Ervervet immunitet- nødvendig for overlevelse, men med risiko for kreft. Fagdagene, åpning av nytt sykehus, St Olav , ST.Olav og NTNU 2010-06-10 -
2009
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Vitenskapelig foredragSlupphaug, Geir; Doseth, Berit; Kavli, Bodil Merete; Visnes, Torkild; Hagen, Lars; Torseth, Kathrin. (2009) Genomic uracil processing in mice and men. 2.nd Erling Seeberg symposium on DNA repair , Ålesund/Geiranger 2009-06-20 - 2009-06-25
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Vitenskapelig foredragKrokan, Hans Einar; Visnes, Torkild; Doseth, Berit; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete. (2009) Uracil in DNA and its processing. E. Dogliotti, H. Krokan, T. Stevnsner, S. Mitra, S.H. Wilson 3rd US-EU Conference- Repair of Endogenous Genome Damage , Moody Gardens Hotel, Galveston, Texas 2009-02-21 - 2009-02-25
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Vitenskapelig foredragHu, Yi; Kavli, Bodil Merete. (2009) The mutator enzyme AID; how is the intracellular localization regulated?. IKM tirsdagsmøte , Lab sentret 2009-11-03 -
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PosterHenrik Sahlin, Pettersen; Visnes, Torkild; Vågbø, Cathrine Broberg; Kavli, Bodil Merete; Krokan, Hans Einar. (2009) Cytotoxicity of 5-fluorouracil is mainly due to RNA effects and thymidylate synthase inhibition, not excessive DNA repair. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair , Ålesund og Geiranger 2009-06-20 - 2009-06-25
2008
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Vitenskapelig foredragKavli, Bodil Merete. (2008) Two levels of protection for the B cell genome during somatic hypermutation. Mandagsmøte IKM 2008-05-25 -
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Vitenskapelig foredragSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance , St. Petersburg 2008-06-24 - 2008-06-26
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Populærvitenskapelig foredragKavli, Bodil Merete. (2008) Uracil i DNA. Bodil Kavli i samarbeid med byåsen videregående skole Foredrag for Bioligistudenter fra Byåsen videregående skole , Laboratoriesenteret, NTNU 2008-03-26 -
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Populærvitenskapelig foredragKavli, Bodil Merete. (2008) Uracil i DNA; generelt mutagen og viktig mellomprodukt i adaptiv immunitet. Silja Strand Storbakken, Byåsen videregående skole Fagdag i biologi for biologilærere i videregående skole 2008-10-30 -
2007
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Vitenskapelig foredragVisnes, Torkild; Kavli, Bodil Merete; Pettersen, Henrik P Sahlin; Krokan, Hans Einar. (2007) Efficient repair of 5-fluorouracil from DNA by base excision repair: roles of UNG2 and SMUG1. EU EU - IP DNA Repair workshop for young scientists , Gent 2007-05-13 - 2007-05-16
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Vitenskapelig foredragKavli, Bodil Merete. (2007) UNG2 and SMUG1 coordinate the initial steps in BER by different mechanisms. IKMM Mandagsforedrag IKMM , Trondheim 2007-05-14 -
2006
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Vitenskapelig foredragKavli, Bodil Merete. (2006) Uracil i DNA; Generelt mutagen og viktig intermediat i adaptive immunitet. Gjesteforelesning for elever ved Høyskolen i Oslo 2006-10-05 -
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Vitenskapelig foredragKavli, Bodil Merete. (2006) UNG2; betydning for utvikling av humaoral immunitet. Institutt seminar 2006-11-28 -
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PosterHagen, Lars; Kavli, Bodil Merete; Sundheim, Ottar; Sousa, Mirta; Otterlei, Marit; Liabakk, Nina-Beate. (2006) Regulation of uracil base excision repair by post-translational modifications. Erling Seeberg Symposium on DNA Repair 2006-05-28 - 2006-06-02
2005
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PosterKavli, Bodil Merete; Diaz, Javier Pena; Otterlei, Marit; Liabakk, Nina-Beate; Giljam, Karin Margaretha; Krokan, Hans Einar. (2005) The enzymatic activity of human uracil-DNA glycosylase UNG2 is regulated by N-terminal phosphorylation during cell cycle. Instituto Superiore di Sanita/EMBO 2nd EU-US DNA Repair Meeting: Endogeneous Stress, Base excision repair and related processes , Erice, Sicily 2005-11-28 - 2005-12-03
2004
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PosterKavli, Bodil; Otterlei, Marit; Liabakk, Nina-Beate; Krokan, Hans Einar; Slupphaug, Geir. (2004) The mutant UNG2-F-25 1S associated with HIGM syndrome is abnormally translocated and degraded, and results in impaired nuclear uracil excision and accumulation of genomic uracil. ASM Conference on DNA Repair and Mutagenesis , Bermuda 2004-11-14 - 2004-11-20
2003
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Populærvitenskapelig foredragKavli, Bodil. (2003) AID og UNG; Nøkkelenzymer i affinitetsmodning av immunoglobuliner og klasse-switch. "Tirsdagsmøte" , Trondheim, Norge 2003-03-11 -
2002
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Vitenskapelig foredragKavli, Bodil. (2002) PCR - polymerase chain reaction. GENTEKNOLOGI - Kurs for lærere . Norgesnettrådet , Trondheim, Norge 2002-10-31 -
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PosterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Otterlei, Marit; Skorpen, Frank. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in DNA-uracil repair in the nucleus. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life , Quality Hotel Røros 2002-01-20 -
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PosterKavli, Bodil; Otterlei, Marit; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Krokan, Hans Einar. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in uracil-DNA repair in the nucleus. Mutagenesis and Carcinogenesis, Gordon Research Conference , Ventura, California, USA 2002-03-08 -
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PosterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Aas, Per Arne. (2002) Substrate preference and enzyme kinetics reveal distinct properties of UNG2 and SMUG1 in cellular base-excision repair; hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup. 32nd Annual Meeting of European Environmental Mutagen Society. DNA Damage and Repair Fundamental Aspects and Contribution to Human Disorders , Warsaw. Poland 2002-09-07 -
2001
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PosterSundheim, Ottar; Otterlei, Marit; Kavli, Bodil; Skorpen, Frank; Aas, Per Arne; Krokan, Hans Einar. (2001) Structure-function analysis of the human uracil-DNA glycosylase hSMUG1. Sixth International School on the Crystallography of Biological Macromolecules. , Como, Italy 2001-05-17 -
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Populærvitenskapelig foredragKavli, Bodil. (2001) Human uracil DNA glucosylases from UNG-gene. Structural basis for substrate specificity and repair. "Tirsdagsmøte" populærvitenskapelig foredrag. , Medisinsk Teknisk Senter 2001-04-17 -
2000
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Populærvitenskapelig foredragKrokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja. (2000) Structure-function aspects of human uracil-DNA glycosylase and its interactions with other proteins. DNA Base Excision Repair Workshop (BER 2000 WORKSHOP) , Galveston, Texas, March 10 - 13, 2000
1999
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PosterKrokan, Hans Einar; Slupphaug, Geir; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank. (1999) Excicion Repar of DNA Damage 1. , 1-7 november 1999
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PosterOtterlei, Marit; Kavli, B.; Standal, R.; Skjelbred, Camilla; Bharati, S.; Krokan, Hans Einar. (1999) In vivo Repair of AP-sites in the E.coli Chromosome. , 1-7 november 1999
1998
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PosterKavli, Bodil; Otterlei, Marit; Skjelbred, Camilla; Standal, Rune; Bharati, Sangeeta; Krokan, Hans Einar. (1998) Mutation frequency and mutation spectra caused by chromosomal AP-site in repair deficient E.coli strains. Norsk Biokjemisk Selskaps møte , Lillehammer
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Populærvitenskapelig foredragKavli, Bodil. (1998) Kartlegging av protein struktur/funksjon vha setespesifikk mutagenese og røntgenkrystallografi. Storlienmøte , Storlien