Geir Slupphaug

Om

Proteomics, Genome Dynamics and DNA repair

I entered the field of mammalian DNA repair in the late 1980ies, moving from plant molecular biology. I then joined the group of Professor Hans E. Krokan, and started working on molecular mechanisms underlying repair of base lesions in DNA. A primary focus of the research was to understand how the erroneous DNA base uracil was removed from DNA. Uracil is a mutagenic DNA lesion occurring several hundred times per day in each cell. It is primarily removed by the enzyme uracil-DNA glycosylase (UNG), that initiates a multistep enzymatic pathway to restore the original DNA sequence. Thanks to the recent cloning of the human UNG gene we were able produce sufficient amounts of recombinant enzyme for functional and 3D-structure analysis. This laid the basis for several fundamental discoveries concerning the functioning of DNA glycosylases, including the concept of DNA base flipping in DNA repair. Much of this research was conducted in collaboration with Prof. John A. Tainer at the Scripps Research Institute in San Diego. I was also fortunate to spend a year in his lab as a guest researcher in the mid-90ies.

Cocrystal structure of UNG and uracil-containing DNA

Through the years it became clear that the nuclear isoform of UNG, UNG2 is a truly multifunctional enzyme. Moreover, we now know that uracil is not a mere lesion in DNA, but can be enzymatically introduced into specific genes. In activated B-cells, the enzyme AID deaminates cytosine to uracil in the immunoglobulin genes. These uracils are also removed by UNG2. Paradoxically, however, the resulting baseless (AP) site is not repaired, but rather funneled through a mutagenic pathway that enhances the affinity as well as the effector functions of the final antibodies. Thus, both AID and UNG2 are crucial for the normal immune response, and lack of UNG2 results in hyper-IgM syndrome in humans. Moreover, mutagenic processing of genomic uracil encompasses several enzymes that normally act in DNA repair pathways, demonstrating the interplay between different cellular functions by employing common factors for different purposes. This, however, does not come without a cost. Recent large-scale sequencing of human cancers indicates that off-targeted enzymatic deamination of cytosine by the AID/APOBEC family of cytidine deaminases may be involved in the development of a large fraction of human cancers, including B-cell lymphomas. We have also observed a marked increase in B-cell lymphomas in Ung-deficient mice.

Model of B-cell lymphoma development in Ung-deficient mice

Finally, UNG2 is also important in the defense against retrovirus, e.g. HIV-1. High concentrations of dUTP in the target cells promote misincorporation of uracil in the viral DNA and host cell APOBEC proteins may promote deamination of cytosine in the viral DNA. This facilitates degradation of viral DNA by UNG2 and AP-endonuclease. In conclusion, uracil in DNA is both a mutagenic burden and a tool to modify DNA for diversity or degradation.

Employing a cellular protein for different functions can be regulated at several levels, e.g. by directing the protein to various subcellular compartments, adjusting its level through the cell cycle, or by introducing specific post-translational modifications to the protein to alter its interaction with other cellular components to e.g. form novel protein complexes. To study such phenomena in more detail we acquired our first mass spectrometry instrument for proteomic analyses in the early 2000nds. This activity has steadily grown and has allowed us to decipher novel regulatory mechanisms both within DNA repair, but also in other biochemical processes linked to human disease. We have also established analytical pipelines for quantitative determination of >50 modified bases in DNA and RNA. This has allowed us to perform parallel monitoring of DNA/RNA modifications and protein profiling in various diseased tissues to aid e.g. biomarker discovery. A present focus of our studies is to map potential functions of DNA modifications previously considered mere lesions, in the fine-tuning of gene-expression and epigenetic reprogramming.

In 2013 the mass spectrometry laboratory at IKM was appointed a core facility for proteomics and metabolomics (PROMEC) at NTNU, and we currently perform analytical service for several research groups both within and outside NTNU.

Davi at the Orbitrap Elite

Current research group (including core facility personnel)

Publikasjoner

2025

Berg, Sigrid Ravn; Brambilla, Alessandro; Hagen, Lars; Sharma, Animesh; Vågbø, Cathrine Broberg; Liabakk, Nina-Beate; Kissova, Miroslava; Barenys, Miquel Arano; Bjørås, Magnar; Torp, Sverre Helge. (2025) Proteomic Analysis Uncovers Enhanced Inflammatory Phenotype and Distinct Metabolic Changes in IDH1 Mutant Glioma Cells. International Journal of Molecular Sciences
Vitenskapelig artikkel
Kissova, Miroslava; Segarra, Judit Martinez; Iveland, Tobias Solli; Vestvik, Marthe; Ravlo, Erlend; Wang, Wei; Hagen, Lars; Liabakk, Nina-Beate; Camara Quilez, Maria; Barenys, Miquel Arano. (2025) RNaseH2 inhibition potentiates temozolomide response in patient derived glioblastoma cells. Scientific Reports
Vitenskapelig artikkel
Schroer, Lisa; Weirich, Sara; Hammerstad, Marta; Hersleth, Hans-Petter; Grønsberg, Ida Andrietta; Hagen, Lars; Slupphaug, Geir; Malecki, Jedrzej Mieczyslaw; Jeltsch, Albert; Falnes, Pål. (2025) Orthologues of the human protein histidine methyltransferase METTL9 display distinct substrate specificities. Journal of Biological Chemistry
Vitenskapelig artikkel
Malecki, Jedrzej Mieczyslaw; Weirich, Sara; Ramirez, Manuel; Hagen, Lars; Al-Egly, Jakin Saad; Anonsen, Jan Haug; Schroer, Lisa; Herrera Gonzalez-Molina, Maria del Carmen; Davydova, Erna; Slupphaug, Geir. (2025) Identification of substrates and sequence requirements for CARNMT1-mediated histidine methylation of C3H zinc fingers. Journal of Biological Chemistry
Vitenskapelig artikkel
Vasuthas, Kalaiyarasi; Christiansen, Sverre Christian; Kjesbu, Joachim Sebastian; Ryan, Liv; Andreassen, Trygve; Slupphaug, Geir; Strand, Berit Løkensgard; Stenvik, Jørgen; Rokstad, Anne Mari A.. (2025) Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences. Materials Today Bio
Vitenskapelig artikkel
Iveland, Tobias Solli; Hagen, Lars; Sousa, Mirta; Liabakk, Nina-Beate; Aas, Per Arne; Sharma, Animesh; Kavli, Bodil Merete; Slupphaug, Geir. (2025) Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA. Scientific Reports
Vitenskapelig artikkel
Vasuthas, Kalaiyarasi; Kjesbu, Joachim Sebastian; Brambilla, Alessandro; Levitan, Maya; Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Strand, Berit Løkensgard; Slupphaug, Geir; Rokstad, Anne Mari A.. (2025) Fucoidan alginate and sulfated alginate microbeads induce distinct coagulation, inflammatory and fibrotic responses. Materials Today Bio
Vitenskapelig artikkel

2024

Schwarz, Simon D.; Xu, Jianming; Gunasekera, Kapila; Schürmann, David; Vågbø, Cathrine Broberg; Ferrari, Elena; Slupphaug, Geir; Hottiger, Michael O.; Schär, Primo; Steinacher, Roland. (2024) Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation. Nature Communications
Vitenskapelig artikkel
Waldum, Helge; Slupphaug, Geir. (2024) Correctly identifying the cells of origin is essential for tailoring treatment and understanding the emergence of cancer stem cells and late metastases. Frontiers in Oncology
Vitenskapelig oversiktsartikkel
Berg, Sigrid Ravn; Demirovic, Aida; Sharma, Animesh; Hagen, Lars; Vågbø, Cathrine Broberg; Zatula, Alexey; Misund, Kristine; Waage, Anders; Slupphaug, Geir. (2024) Progression of monoclonal gammopathy of undetermined significance to multiple myeloma is associated with enhanced translational quality control and overall loss of surface antigens. Journal of Translational Medicine
Vitenskapelig artikkel

2023

Hayran , Abdul Baset ; Liabakk, Nina-Beate; Aas, Per Arne; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Sarno, Antonio; Iveland, Tobias Solli; Chawla, Konika; Zahn, Astrid; DiNoia, Javier M. (2023) RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Gederaas, Odrun Arna; Sharma, Animesh; Mbarak, Saide; Sporsheim, Bjørnar; Høgset, Anders; Bogoeva, Vanya; Slupphaug, Geir; Hagen, Lars. (2023) Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells. Molecular Omics
Vitenskapelig artikkel
Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi; Lång, Anna Ulrika; Kristiansen, Elise; Pannone, Marco; Kissova, Miroslava. (2023) A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment. Genome Biology
Vitenskapelig artikkel

2022

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2022) MS-proteomics provides insight into the host responses towards alginate microspheres. Materials Today Bio
Vitenskapelig artikkel

2021

Alves, Christiano R. R.; Eichelberger, Eric J.; Neves, Willian das; Ribeiro, Márcio A. C.; Bechara, Luiz R.G.; Voltarelli, Vanessa A.; Almeida, Ney R. de; Hagen, Lars; Sharma, Animesh; Ferreira, Julio C. B.. (2021) Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity. The FASEB Journal
Vitenskapelig artikkel
Olinski, Ryszard; Slupphaug, Geir; Foksinski, Marek; Krokan, Hans Einar. (2021) Genomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignancies. International Journal of Molecular Sciences
Vitenskapelig artikkel
Kavli, Bodil Merete; Iveland, Tobias Solli; Buchinger, Edith; Hagen, Lars; Liabakk, Nina-Beate; Aas, Per Arne; Obermann, Tobias Sebastian; Aachmann, Finn Lillelund; Slupphaug, Geir. (2021) RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Wang, Qiong; Karvelsson, Sigurdur Trausti; Johannsson, Freyr; Vilhjalmsson, Arnar Ingi; Hagen, Lars; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Rolfsson, Ottar. (2021) UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines. Molecular Oncology
Vitenskapelig artikkel
Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Berrocal, Marion Silvana Fernandez; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna. (2021) NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. Communications Biology
Vitenskapelig artikkel
Alswady-Hoff, Mayes; Erdem, Johanna Maria Samulin; Phuyal, Santosh; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Skare, Øivind; Slupphaug, Geir; Zienolddiny, Shanbeh. (2021) Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells. International Journal of Molecular Sciences
Vitenskapelig artikkel
Iveland, Tobias S.; Hagen, Lars; Sharma, Animesh; Sousa, Mirta M. L.; Sarno, Antonio; Wollen, Kristian Lied; Liabakk, Nina-Beate; Slupphaug, Geir. (2021) Correction to: HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines (Journal of Translational Medicine, (2020), 18, 1, (159), 10.1186/s12967-020-02318-8). Journal of Translational Medicine
Korrigendum
Steen, Kristian Wollen; Hagen, Lars; Vågbø, Cathrine Broberg; Rabe, Renana; Iveland, Tobias Solli; Aas, Per Arne; Sharma, Animesh; Sporsheim, Bjørnar; Erlandsen, Hilde; Palibrk, Vuk. (2021) ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA. Journal of Translational Medicine
Vitenskapelig artikkel

2020

Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2020) Genomic Uracil in Biology, Immunity and Cancer.
Vitenskapelig kapittel
Iveland, Tobias Solli; Hagen, Lars; Sharma, Animesh; Sousa, Mirta; Sarno, Antonio; Wollen, Kristian Lied; Liabakk, Nina-Beate; Slupphaug, Geir. (2020) HDACi Mediate UNG2 Depletion, Dysregulated Genomic Uracil and Altered Expression of Oncoproteins and Tumor Suppressors in B- And T-cell Lines. Journal of Translational Medicine
Vitenskapelig artikkel
Eldin, Patrick; Péron, Sophie; Galashevskaya, Anastasia; Denis-Lagache, Nicolas; Cogné, Michel; Slupphaug, Geir; Briant, Laurence. (2020) Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination. Journal of Translational Medicine
Vitenskapelig artikkel
Vågbø, Cathrine Broberg; Slupphaug, Geir. (2020) RNA in DNA repair. DNA Repair
Vitenskapelig artikkel
Yang, Rui; Elsaadi, Samah; Misund, Kristine; Abdollahi, Pegah; Vandsemb, Esten; Moen, Siv Helen; Kusnierczyk, Anna; Slupphaug, Geir; Standal, Therese; Waage, Anders. (2020) Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade. Journal for ImmunoTherapy of Cancer (JITC)
Vitenskapelig artikkel
Alves, Christiano R. R.; Neves, Willian des; Almeida, Ney R de; Eichelberger, Eric J; Jannig, Paulo R.; Voltarelli, Vanessa A; Tobias, Gabriel C; Bechara, Luiz R G; Faria, Daniele de Paula; Alves, Maria J N. (2020) Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN. Molecular Metabolism
Vitenskapelig artikkel

2019

Steinacher, Roland; Barekati, Zeinab; Botev, Petar; Kusnierczyk, Anna; Slupphaug, Geir; Schär, Primo. (2019) SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation. EMBO Journal
Vitenskapelig artikkel
Macur, Katarzyna; Hagen, Lars; Ciesielski, Tomasz Maciej; Konieczna, Lucyna; Skokowski, Jaroslaw; Jenssen, Bjørn Munro; Slupphaug, Geir; Baczek, Tomasz. (2019) A targeted mass spectrometry immunoassay to quantify osteopontin in fresh-frozen breast tumors and adjacent normal breast tissues. Journal of Proteomics
Vitenskapelig artikkel
Pinto, Rita; Vågbø, Cathrine Broberg; Jakobsson, Magnus; Yeji, Kim; Baltissen, Marijke P; O'Donohue, Marie-Francoise; Guzman, Ulises H; Malecki, Jedrzej Mieczyslaw; Wu, Jie; Kirpekar, Finn. (2019) The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Nucleic Acids Research (NAR)
Vitenskapelig artikkel

2018

Zhao, Chun-Mei; Rabben, Hanne-Line; Zhu, Yanping; Olsen, Magnus Kringstad; Wang, Zhiqiang; Hao, Yanpeng; Cai, Xing; Fonseca, Davi de Miranda; Sharma, Animesh; Li, Mingna. (2018) 390 - A New Treatment for Pancreatic Cancer: Targeting Nervecancer Cell Crosstalk. Gastroenterology
Konferanseabstract
Krokan, Hans Einar; Kavli, Bodil Merete; Sarno, Antonio; Slupphaug, Geir. (2018) Enzymology of Genomic Uracil Repair.
Faglig kapittel
Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil – Valuable Tool in Molecular Biology but Inherent Problem in Sequencing of Ancient DNA.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir; Drabløs, Finn. (2018) The Earth, Life and Genomic Uracil.
Faglig kapittel
Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil - Evolution, Biology, Immunology and Disease. World Scientific
Faglig monografi
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) DNA Repair is Integrated with Many Cellular Processes.
Faglig kapittel
Kavli, Bodil Merete; Slupphaug, Geir. (2018) Genomic Uracil and Immunity.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) Viral Uracil - Uracil DNA glycosylases and dUTPases.
Faglig kapittel
Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2018) Routes to Uracil in DNA.
Faglig kapittel
Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo; Bianco Nascimento Moreira, Jose; Alves, Marcia Netto Magalhaes; Wohlwend, Martin; Gebriel, Mohammed; Hagen, Lars. (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Scientific Reports
Vitenskapelig artikkel
Phuyal, Santosh; Kasem, Mayes; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Vebraite, Vaineta; Shaposhnikov, Sergey; Slupphaug, Geir; Skaug, Vidar; Zienolddiny, Shanbeh. (2018) Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes. Nanotoxicology
Vitenskapelig artikkel

2017

Rydning, Siri Lynne; Backe, Paul Hoff; Sousa, Mirta; Iqbal, Zafar; Øye, Ane-Marte; Sheng, Ying; Yang, Mingyi; Lin, Xiaolin; Slupphaug, Geir; Nordenmark, Tonje Haug. (2017) Corrigendum: Novel UCHL1 mutations reveal new insights into ubiquitin processing. Human Molecular Genetics
Korrigendum
Zatula, Alexey; Dikic, Aida; Mulder, Teska Celine; Sharma, Animesh; Vågbø, Cathrine Broberg; Sousa, Mirta; Waage, Anders; Slupphaug, Geir. (2017) Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia. OncoTarget
Vitenskapelig artikkel
Brickner, Joshua R; Soll, Jennifer M; Lombardi, Patrick M; Vågbø, Cathrine Broberg; Mudge, Miranda C; Oyeniran, Clement; Rabe, Renana; Jackson, Jessica; Sullender, Meagan E; Blazosky, Elyse. (2017) A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir; Kavli, Bodil Merete. (2017) Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig kapittel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel. Data in Brief
Vitenskapelig artikkel
Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja; Neurauter, Christine Gran; Esbensen, Qin Ying; Kusnierczyk, Anna; Hildrestrand, Gunn Annette; Graupner, Anne. (2017) No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Scientific Reports
Vitenskapelig artikkel
Rydning, Siri Lynne; Backe, Paul Hoff; Sousa, Mirta; Iqbal, Zafar; Øye, Ane-Marte; Sheng, Ying; Yang, Mingyi; Lin, Xiaolin; Slupphaug, Geir; Nordenmark, Tonje Haug. (2017) Novel UCHL1 mutations reveal new insights into ubiquitin processing. Human Molecular Genetics
Vitenskapelig artikkel
Buchinger, Edith; Wiik, Siv Åshild; Kusnierczyk, Anna; Rabe, Renana; Aas, Per Arne; Kavli, Bodil Merete; Slupphaug, Geir; Aachmann, Finn Lillelund. (2017) Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2. Biomolecular NMR Assignments
Vitenskapelig artikkel
Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein. (2017) NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports
Vitenskapelig artikkel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay. Analytical Biochemistry
Vitenskapelig artikkel

2016

Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna. (2016) Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice. Scientific Reports
Vitenskapelig artikkel
Skarpengland, Tonje; Dahl, Tuva Børresdatter; Skjelland, Mona; Scheffler, Katja; Sousa, Mirta; Gregersen, Ida; Kusnierczyk, Anna; Sharma, Animesh; Slupphaug, Geir; Eide, Lars. (2016) Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA. Free Radical Biology & Medicine
Vitenskapelig artikkel
Slupphaug, Geir. (2016) Modulering av cellulær metabolisme bidrar til Melfalan-resistens i myelomaotse. Best Practice Onkologi/Hematologi
Fagartikkel
Iversen, Ole-Jan; Lysvand, Hilde; Slupphaug, Geir. (2016) Pso p27, a SERPINB3/B4-derived protein, is most likely a common autoantigen in chronic inflammatory diseases. Clinical Immunology
Vitenskapelig artikkel
Helander, Linda; Sharma, Animesh; Krokan, Hans Einar; Plaetzer, Kristjan; Krammer, Barbara; Tortik, Nicole; Gederaas, Odrun Arna; Slupphaug, Geir; Hagen, Lars. (2016) Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins. Molecular Biosystems
Vitenskapelig artikkel

2015

Lysvand, Hilde; Helland, Ronny; Hagen, Lars; Slupphaug, Geir; Iversen, Ole-Jan. (2015) Psoriasis pathogenesis – Pso p27 constitutes a compact structure forming large aggregates. Biochemistry and Biophysics Reports
Vitenskapelig artikkel
Mjelle, Robin; Hegre, Siv Anita; Aas, Per Arne; Slupphaug, Geir; Drabløs, Finn; Sætrom, Pål; Krokan, Hans Einar. (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair
Vitenskapelig artikkel
Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars. (2015) Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports
Vitenskapelig artikkel
Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål. (2015) AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA Repair
Vitenskapelig artikkel
Zub, Kamila; Sousa, Mirta; Sarno, Antonio; Sharma, Animesh; Dikic, Aida; Rao, Shalini; Young, Clifford; Aas, Per Arne; Ericsson, Ida; Sundan, Anders. (2015) Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired Melphalan resistance in multiple myeloma cells. PLOS ONE
Vitenskapelig artikkel
Rolim, Natale Pinheiro Lage; Skårdal, Kristine; Høydal, Morten; Sousa, Mirta; Malmo, Vegard; Skrove, Guri Kaurstad; Ingul, Charlotte Bjørk; Hansen, Harald Edvard Mølmen; Alves, Marcia Netto Magalhaes; Thuen, Marte. (2015) Aerobic interval training reduces inducible ventricular arrhytmias in diabetic mice after myocardial infarction. Basic Research in Cardiology
Vitenskapelig artikkel
Kataya, Amr Ramzy Abass; Heidari, Behzad; Hagen, Lars; Kommedal, Roald; Slupphaug, Geir; Lillo, Cathrine. (2015) Supplemental materials for: Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Plant Physiology
Vitenskapelig artikkel

2014

Lysvand, Hilde; Hagen, Lars; Klubicka, Lidija; Slupphaug, Geir; Iversen, Ole-Jan. (2014) Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase. Biochimica et Biophysica Acta - Molecular Basis of Disease
Vitenskapelig artikkel
Hagen, Lars; Sharma, Animesh; Aas, Per Arne; Slupphaug, Geir. (2014) Off-target responses in the HeLa proteome subsequent to transient plasmid-mediated transfection. Biochimica et Biophysica Acta - Proteins and Proteomics
Vitenskapelig artikkel
Krokan, Hans Einar; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Kavli, Bodil Merete; Slupphaug, Geir. (2014) Error-free versus mutagenic processing of genomic uracil-Relevance to cancer. DNA Repair
Vitenskapelig artikkel
Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Abdollahi, Pegah; Vansemb, Esten; Hagen, Lars; Baranowska, Katarzyna Anna; Misund, Kristine; Slupphaug, Geir; Børset, Magne. (2014) PRL-3 Mediates Survival of Primary Myeloma Cells. Blood
Konferanseabstract
Kataya, Amr Ramzy Abass; Ahootapeh, Behzad Heidari; Hagen, Lars; Kommedal, Roald; Slupphaug, Geir; Lillo, Cathrine. (2014) Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Plant Physiology
Vitenskapelig artikkel

2013

Sousa, Mirta; Zub, Kamila Anna; Aas, Per Arne; Hanssen-Bauer, Audun; Demirovic, Aida; Sarno, Antonio; Tian, Erming; Liabakk, Nina-Beate; Slupphaug, Geir. (2013) An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. PLOS ONE
Vitenskapelig artikkel
Hu, Yi; Ericsson, Ida; Torseth, Kathrin; Methot, Stephen; Sundheim, Ottar; Liabakk, Nina-Beate; Slupphaug, Geir; Noia, Javier Di; Krokan, Hans Einar; Kavli, Bodil Merete. (2013) A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching. Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
Johnsen, Anne Berit; Rolim, Natale Pinheiro Lage; Stølen, Tomas; Alves, Marcia; Sousa, Mirta; Slupphaug, Geir; Britton, Steven L; Koch, Lauren G; Smith, Godfrey L; Wisløff, Ulrik. (2013) Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity. PLOS ONE
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Ericsson, Ida; Galashevskaya, Anastasia; Sarno, Antonio; Aas, Per Arne; Vagbo, CB; Pettersen, Henrik P Sahlin; Slupphaug, Geir. (2013) Genomic uracil - potent mutagen but normal intermediate in adaptive immunity. The FEBS Journal
Konferanseabstract
Galashevskaya, Anastasia; Sarno, Antonio; Vågbø, Cathrine Broberg; Aas, Per Arne; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2013) A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported. DNA Repair
Vitenskapelig artikkel

2012

Johannessen, Helene; Kodama, Yosuke; Zhao, Chun-Mei; Sousa, Mirta; Slupphaug, Geir; Kulseng, Bård Eirik; Chen, Duan. (2012) Eating Behavior and Glucagon-Like Peptide-1-Producing Cells in Interposed Ileum and Pancreatic Islets in Rats Subjected to Ileal Interposition Associated with Sleeve Gastrectomy. Obesity Surgery
Vitenskapelig artikkel
Torseth, Kathrin; Doseth, Berit; Hagen, Lars; Olaisen, Camilla; Liabakk, Nina-Beate; Græsmann, Heidi; Durandy, Anne; Otterlei, Marit; Krokan, Hans Einar; Kavli, Bodil Merete. (2012) The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA. DNA Repair
Vitenskapelig artikkel
Doseth, Berit; Ekre, Cecilie; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2012) Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil. DNA Repair
Vitenskapelig artikkel
Roberts, Victoria A.; Pique, Michael E.; Hsu, Simon; Li, Sheng; Slupphaug, Geir; Rambo, Robert P.; Jamison, Jonathan P.; Liu, Tong; Lee, Jun H.; Tainer, John A.. (2012) Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Steen, Kristian Wollen; Doseth, Berit; Westbye, Marianne Pedersen; Akbari, Mansour; Kang, D; Falkenberg, Maria; Slupphaug, Geir. (2012) mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored. DNA Repair
Vitenskapelig artikkel

2011

Baglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda; Zub, Kamila; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Photochemical and Photobiological Sciences
Vitenskapelig artikkel
Sousa, Mirta; Steen, Kristian Wollen; Hagen, Lars; Slupphaug, Geir. (2011) Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis. Proteome Science
Vitenskapelig artikkel
Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Hanssen-Bauer, Audun; Garten, Karin Solvang-; Sundheim, Ottar; Diaz, Javier Pena; Andersen, Sonja Benedikte; Slupphaug, Geir; Krokan, Hans Einar; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2011) XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage. Environmental and Molecular Mutagenesis
Vitenskapelig artikkel
Zeitlin, SG; Chapados, BR; Baker, NM; Tai, C; Slupphaug, Geir; Wang, JYJ. (2011) Uracil DNA N-Glycosylase Promotes Assembly of Human Centromere Protein A. PLOS ONE
Vitenskapelig artikkel
Doseth, Berit; Visnes, Torkild; Wallenius, Anders; Ericsson, Ida; Sarno, Antonio; Pettersen, Henrik Sahlin; Flatberg, Arnar; Catterall, Tara Cherie; Slupphaug, Geir; Krokan, Hans Einar. (2011) Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE. Journal of Biological Chemistry
Vitenskapelig artikkel

2010

Monsen, Vivi A Talstad; Sundheim, Ottar; Aas, Per Arne; Westbye, Marianne Pedersen; Sousa, Mirta; Slupphaug, Geir; Krokan, Hans Einar. (2010) Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Bergstrøm, Bjarte Aune; Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit Walbye. (2010) Identification of a Novel in Vivo Virus-targeted Phosphorylation Site in Interferon Regulatory Factor-3 (IRF3). Journal of Biological Chemistry
Vitenskapelig artikkel
Baglo, Yan; Gederaas, Odrun Arna; Slupphaug, Geir. (2010) Effects of Photodynamic Therapy on Protein Expression in Rat Bladder Cancer Cells. NTNU-trykk
Masteroppgave
Felberg, Hanne Solvang; Hagen, Lars; Slupphaug, Geir; Batista, Irineu; Nunes, Maria Leonora; Olsen, Ragnar Ludvig; Martinez, iciar. (2010) Partial characterisation of gelatinolytic activities in herring (Clupea harengus) and sardine (Sardina pilchardus) possibly involved in post-mortem autolysis of ventral muscle. Food Chemistry
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Otterlei, Marit; Akbari, M.; Slupphaug, Geir; Aas, Per Arne. (2010) DNA repair and cancer. European Journal of Cancer
Konferanseabstract

2009

Knaevelsrud, I; Knaevelsrud, I; Slupphaug, G; Leiros, Ingar; Matsuda, A; Ruoff, P; Ruoff, P; Bjelland, S; Bjelland, S. (2009) Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology
Vitenskapelig artikkel
Knævelsrud, I.; Slupphaug, Geir; Leiros, Ingar; Matsuda, A.; Ruoff, Peter; Bjelland, Svein. (2009) Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology
Vitenskapelig artikkel
Langevin, C; Maidou-Peindara, P; Aas, Per Arne; Jacquot, G; Otterlei, Marit; Slupphaug, Geir; Benichou, S. (2009) Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect. Journal of Virology
Vitenskapelig artikkel
Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology
Vitenskapelig artikkel
Visnes, Torkild; Doseth, Berit; Pettersen, Henrik Sahlin; Hagen, Lars; Sousa, Mirta; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2009) Uracil in DNA and its processing by different DNA glycosylases. Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel

2008

Sundheim, Ottar; Talstad, Vivi A; Vågbø, Cathrine Broberg; Slupphaug, Geir; Krokan, Hans Einar. (2008) AlkB demethylases flip out in different ways. DNA Repair
Vitenskapelig artikkel
Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry
Vitenskapelig artikkel
Visnes, Torkild; Akbari, Mansour; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2008) The rate of base excision repair of uracil is controlled by the initiating glycosylase. DNA Repair
Vitenskapelig artikkel
Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Liabakk, Nina-Beate; Sundheim, Ottar; Diaz, Javier Pena; Otterlei, Marit; Hørning, Ole; Jensen, Ole N. (2008) Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO Journal
Vitenskapelig artikkel

2007

Sterten, Heidi; Krøkje, Åse; Otterlei, Marit; Slupphaug, Geir. (2007) Ekspresjon, rensing og funksjonelle studier av rekombinant humant replikasjonsprotein A (RPA). NTNU
Masteroppgave
Azizyan, Mahnaz; Anthonsen, Thorleif; Slupphaug, Geir. (2007) Studier av human mitokondriell uracil-DNA glukosylase UNG1. NTNU
Masteroppgave
Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel
Sousa, Mirta; Krokan, Hans Einar; Slupphaug, Geir. (2007) DNA-uracil and human pathology. Molecular Aspects of Medicine
Vitenskapelig oversiktsartikkel
Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) Uracil in DNA - General mutagen, but normal intermediate in acquired immunity. DNA Repair
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA- from molecular biology to phenotype. DNA Repair
Konferanseabstract
Krokan, Hans Einar; Kavli, Bodil Merete; Akbari, Mansour; Visnes, Torkild; Pettersen, Henrik P Sahlin; Sundheim, Ottar; Hagen, Lars; Otterlei, Marit; Gilljam, Karin Margaretha; Slupphaug, Geir. (2007) Repair og uracil in DNA by UNG2 and SMUG1 - an update. DNA Repair
Konferanseabstract
Parsons, Jason L.; Kavli, Bodil Merete; Slupphaug, Geir; Dianov, Grigory L.. (2007) NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break. Biochemistry
Vitenskapelig artikkel
Pettersen, Henrik P Sahlin; Sundheim, Ottar; Gilljam, Karin Margaretha; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2007) Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Lu, CC; Huang, HT; Wang, JT; Slupphaug, Geir; Li, TK; Wu, MC; Chen, YC; Lee, CP; Chen, MR. (2007) Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication. Journal of Virology
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA - From molecular biology to phenotype - Preface. DNA Repair
Leder

2006

Krokan, Hans Einar; Slupphaug, Geir. (2006) Preface. DNA Repair
Vitenskapelig artikkel
Hagen, Lars; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2006) Genomic uracil and human disease. Experimental Cell Research
Vitenskapelig oversiktsartikkel
Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Mittelstedt, L.Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO Journal
Vitenskapelig artikkel
Krokan, Hans Einar; Akbari, Mansour; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Ericsson, Madelene; Aarset, Harald; Andersen, Sonja Benedikte; Slupphaug, Geir. (2006) Base excision repair proteins in cancer prevention and acquired immune responses. The FEBS Journal
Konferanseabstract

2005

Andersen, S; Ericsson, M; DAI, H; Peña-Diaz, J; Slupphaug, G; Nilsen, Hilde; Aarset, H; Krokan, HE. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair
Vitenskapelig artikkel
Fensgård, Øyvind; Bones, Atle M; Slupphaug, Geir. (2005) Separation of UNG-associated repair protein complexes using gradient centrifugation techniques. Norwegian University of Science and Technology
Masteroppgave
Kavli, Bodil Merete; Andersen, Sonja Benedikte; Otterlei, Marit; Liabakk, Nina-Beate; Imai, K; Fischer, A; Durandy, A; Krokan, Hans Einar; Slupphaug, Geir. (2005) B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
Andersen, Sonja Benedikte; Ericsson, Maria Elisabeth Madelene; Dai, HY; Diaz, Javier Pena; Slupphaug, Geir; Nilsen, H; Aarset, H; Krokan, Hans Einar. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair
Vitenskapelig artikkel
Zeitlin, SG; Patel, S; Kavli, Bodil Merete; Slupphaug, Geir. (2005) Xenopus CENP - A assembly into chromatin requires base excision repair proteins. DNA Repair
Vitenskapelig artikkel

2004

Diaz, Javier Pena; Akbari, Mansour; Sundheim, Ottar; Farez-Vidal, ME; Andersen, S; Sneve, R; Gonzalez-Pacanowska, D; Krokan, Hans Einar; Slupphaug, Geir. (2004) Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair. Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Aas, Per Arne; Kavli, Bodil; Liabakk, Nina-Beate; Hagen, Lars; Imai, K; Durandy, A; Slupphaug, Geir. (2004) Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair
Vitenskapelig oversiktsartikkel
Krokan, Hans Einar; Slupphaug, Geir. (2004) Novel aspects of macromolecular repair and relationship to human disease. Journal of Molecular Medicine
Vitenskapelig oversiktsartikkel

2003

Slupphaug, Geir; Kavli, Bodil; Krokan, Hans Einar. (2003) Interacting pathways that prevent and repair oxidative DNA damage. Mutation Research (DNA Repair)
Vitenskapelig artikkel
Imai, K; Slupphaug, Geir; Lee, W-I; Revy, P; Nonoyama, S; Catalan, N; Yel, L; Forveille, M; Kavli, Bodil; Krokan, Hans Einar. (2003) Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch. Nature Immunology
Vitenskapelig artikkel
Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature
Vitenskapelig artikkel

2002

Grøsvik, K; Slupphaug, Geir; Krokan, Hans Einar. (2002) "Characterisation of uracil-exising enzyme activities in organ extracts from UNG knockout and wild-type mice.". NTNU
Masteroppgave
Nygård, M; Nilsen, M; Remseth, V; Slupphaug, Geir; Krokan, Hans Einar. (2002) Uttrykk av det membran-modifiserende enzymet UDPDG i E.coli som funksjon av dyrkningsbetingelser og induksjon av DNA-skader. [Mangler utgivernavn]
Masteroppgave
Johansen, Tor Arne; Petersen, Idar; Slupphaug, Geir. (2002) Explicit sub-optimal linear quadratic regulation with state and input constraints. Automatica
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2002) Damage and repair of DNA in mammalian cells-emphasis on oxidative damage. Proceedings from International Symposium "Natural Ionising Radiation and Health". Det Norske Videnskaps-Akademi : proceedings
Vitenskapelig artikkel
Krokan, Hans Einar; Drabløs, Finn; Slupphaug, Geir. (2002) Uracil in DNA, occurrence, consequences and repair. Oncogene
Vitenskapelig artikkel
Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Skorpen, Frank; Aas, Per Arne; Hagen, Lars; Krokan, Hans Einar; Slupphaug, Geir. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry
Vitenskapelig artikkel

2001

Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Skjelbred, Camilla Furu; Akbari, Mansour; Aas, Per Arne; Slupphaug, Geir. (2001) Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne; Foss, Bjarne Anton. (2001) Linear MPC with Optimal Prioritized Infeasibility Handling: Application, Computational Issues and Stability. Automatica
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (2001) Efficient Optimal Prioritized Infeasibility Handling in Model Predictive Control - A Parametric Preemptive Multi-objective Linear Programming Approach. Journal of Optimization Theory and Applications
Vitenskapelig artikkel
Cappelli, E.; Hazra, T.; Hill, J.; Slupphaug, Geir; Bobliolo, M.; Frosina, G.. (2001) Rates of base excision repair are not solely dependent on levels of initiating enzymes. Carcinogenesis
Vitenskapelig artikkel

2000

Slupphaug, Geir; Foss, Bjarne Anton. (2000) Nonlinear robust constrained control of partially uncontrollable and open-loop unstable systems. Journal of Process Control
Vitenskapelig artikkel
Slupphaug, Geir; Imsland, Lars Struen; Foss, Bjarne Anton. (2000) Uncertainty modelling and robust output feedback control of nonlinear discrete systems: a mathematical programming approach. International Journal of Robust and Nonlinear Control
Vitenskapelig artikkel
Johansen, Tor Arne; Slupphaug, Geir. (2000) Comment on "Stability issues on Takagi-Sugeno fuzzy model - parametric approach". IEEE transactions on fuzzy systems
Vitenskapelig artikkel
Imsland, Lars Struen; Slupphaug, Geir; Foss, Bjarne Anton. (2000) Robust output feedback control for constrained discrete-time nonlinear systems using observer-based controllers. ITK
Forskningsrapport
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Parikh, Sudip S.; Walcher, Gunter; Jones, Garry D.; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.Michael; Tainer, John A.. (2000) Uracil-DNA glycosylase-DNA substrate and product structures:Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, Hilde; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters
Vitenskapelig artikkel
Nilsen, Hilde; Rosewell, I.; Robins, P.; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Krokan, Hans Einar; Lindahl, T.; Barnes, D.E.. (2000) ) Ung-deficient mice reveal a primary role of the uracil-DNA glycosylase enzyme during DNA replication. Molecular Cell
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, H.; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair in mammalian cells. FEBS Letters
Vitenskapelig artikkel
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Parikh, S; Walcher, G; Jones, G.D; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.M; Tainer, J.A. (2000) Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
Nilsen, Hilde; Rosewell, Ian; Robins, Peter; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Daly, Graham; Krokan, Hans Einar; Lindahl, Tomas; Barnes, Deborah E.. (2000) URACIL-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication. Molecular Cell
Vitenskapelig artikkel

1999

Slupphaug, Geir; Foss, Bjarne Anton. (1999) Constrained quadratic stabilization of discrete-time uncertain non-linear multi-model systems using piecewise affine state-feedback. International Journal of Control
Vitenskapelig artikkel
Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bhariti, Sangeeta; Steinsbekk, Kristin; Nilsen, Hilde; Skjelbred, Camilla; Kavli, Bodil; Standal, Rune; Slupphaug, Geir. (1999) Human uracil-DNA glycosylase. NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (1999) Efficient optimal prioritized infeasibility handling in model predictive control - a parametric preemptive multi-objective linear programming approach. Institutt for teknisk kybernetikk, NTNU
Forskningsrapport
Otterlei, Marit; Warbrick, Emma; Nagelhus, Toril; Haug, Terje; Slupphaug, Geir; Akbari, Mansour; Aas, Per Arne; Steinsbekk, Kristin; Bakke, Oddmund; Krokan, Hans Einar. (1999) Post-replicative base excision repair in replication foci. EMBO Journal
Vitenskapelig artikkel

1998

Slupphaug, Geir. (1998) On robust constrained nonlinear control and hybrid control : BMI and MPC based state-feedback schemes. Institutt for teknisk kybernetikk, NTNU
Doktoravhandling
Krokan, Hans Einar; Parikh, S.S.; Slupphaug, Geir; Bharati, S; Trainer, J.A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO Journal
Vitenskapelig artikkel
Bharati, S.; Krokan, Hans Einar; Kristiansen, L; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Parikh, S. Sudip; Mol, Clifford D.; Slupphaug, Geir; Bharati, Sangeta; Krokan, Hans Einar; Yainer, John A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Otterlei, Marit; Haug, T.; Nagelhus, T.A; Slupphaug, Geir; Lindmo, T.; Krokan, Hans Einar. (1998) Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (1998) DNA-reparasjonsenzymer og deres gener. Tidsskrift for Den norske legeforening (Tidsskriftet)
Vitenskapelig artikkel

1997

Krokan, Hans Einar; Standal, Rune; Bharati, Sangeeta; Otterlei, Marit; Haug, Terje; Slupphaug, Geir; Skorpen, Frank. (1997) Uracil in DNA and the family of concerved uracil DNA glycosylases.
Vitenskapelig kapittel
Krokan, Hans Einar; Standal, Rune; Slupphaug, Geir. (1997) DNA glycosylase in the base excision repair of DNA. Biochemical Journal
Vitenskapelig artikkel

1996

Dizdaroglu, Miral; Karakaya, Asuman; Jaruga, Pawel; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Slupphaug, Geir; Mol, Clifford D.; Kavli, Bodil; Arvai, Andrew S.; Krokan, Hans Einar; Tainer, John A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature
Vitenskapelig artikkel
Kavli, Bodil; Slupphaug, Geir; Mol, Clifford D.; Arvai, Andrew S.; Petersen, Steffen B.; Tainer, John A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Slupphaug, Geir; Foss, Bjarne Anton. (1996) Model predictive control for a class of hybrid systems. NTNU. Inst. f. teknisk kybernetikk
Forskningsrapport
Nagelhus, T.; Slupphaug, Geir; Krokan, Hans Einar; Lindmo, T.. (1996) Fading correction for fluorescence quantitation in confocal microscopy. Cytometry
Vitenskapelig artikkel
Bouhamdan, M; Benichou, S.; Rey, F.; Navarro, J.M.; Agostini, I.; Spire, B.; Camanis, G.; Slupphaug, Geir; Vigne, R; Benarous, R. (1996) Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme. Journal of Virology
Vitenskapelig artikkel
Kavli, B.; Slupphaug, Geir; Mol, C.D.; Arvai, A.S.; Petersen, S.B.; Tainer, J.A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Slupphaug, Geir; Kavli, B.; Mol, C.D.; Arvai, A.; Krokan, Hans Einar; Tainer, J.A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature
Vitenskapelig artikkel
Dizdaroglu, M.; Karakaya, A.; Jaruga, P.; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR)
Vitenskapelig artikkel

1995

Slupphaug, Geir. (1995) A note on hybrid systems emphasizing approaches in the control community. Norges tekniske høgskole. Institutt for teknisk kybernetikk
Forskningsrapport
Slupphaug, Geir. (1995) A brief introduction to some logics, formal languages and Petri net theory. Norges tekniske høgskole. Institutt for teknisk kybernetikk
Forskningsrapport
Slupphaug, Geir; Halvorsen, Ivar. (1995) Forprosjekt: Regulering og overvåking av komplekse industrianlegg. NTH. Institutt for teknisk kybernetikk
Forskningsrapport
Slupphaug, Geir; Eftedal, Ingrid; Kavli, Bodil; Bharati, Sangeeta; Helle, Nils M; Haug, Terje; Levine, David William; Krokan, Hans Einar. (1995) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry
Vitenskapelig artikkel

1994

Brenne, Wenche; Slupphaug, Geir. (1994) Immunologiske studier av humant uracil-DNA glycosylase. Universitetet i Trondheim
Masteroppgave

1993

Eftedal, Ingrid; Guddal, Per Henrik; Slupphaug, Geir; Volden, Gunnar; Krokan, Hans Einar. (1993) Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Slupphaug, G.; Markussen, F.-H.; Olsen, Lisbeth Charlotte; Aasland, Rein; Aarsæther, Niels; Bakke, O.; Krokan, H. E.; Helland, Dag Emil. (1993) Human Uracil-DNA glycosylase is shared by the nucleus and the mitochondria. Nucleic Acid Res
Vitenskapelig artikkel
Iversen, Tor-Henning; Bones, Atle M.; Slupphaug, Geir. (1993) Bioteknologi - 2 timers valgfag. Gyldendal Akademisk
Faglig monografi
Slupphaug, Geir; Alseth, Ingrun; Eftedal, Ingrid; Volden, Gunnar; Krokan, Hans Einar. (1993) Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification. Analytical Biochemistry
Vitenskapelig artikkel

1991

Slupphaug, G.; Olsen, Lisbeth Charlotte; Helland, Dag Emil; Aasland, Rein; Krokan, H. E.. (1991) Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil- DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel

1990

Thangstad, Ole Petter; Iversen, Tor-Henning; Slupphaug, Geir; Bones, Atle M.. (1990) Immunocytochemical localization of myrosinase. Planta
Vitenskapelig artikkel

Tidsskriftspublikasjoner

Berg, Sigrid Ravn; Brambilla, Alessandro; Hagen, Lars; Sharma, Animesh; Vågbø, Cathrine Broberg; Liabakk, Nina-Beate; Kissova, Miroslava; Barenys, Miquel Arano; Bjørås, Magnar; Torp, Sverre Helge. (2025) Proteomic Analysis Uncovers Enhanced Inflammatory Phenotype and Distinct Metabolic Changes in IDH1 Mutant Glioma Cells. International Journal of Molecular Sciences
Vitenskapelig artikkel
Kissova, Miroslava; Segarra, Judit Martinez; Iveland, Tobias Solli; Vestvik, Marthe; Ravlo, Erlend; Wang, Wei; Hagen, Lars; Liabakk, Nina-Beate; Camara Quilez, Maria; Barenys, Miquel Arano. (2025) RNaseH2 inhibition potentiates temozolomide response in patient derived glioblastoma cells. Scientific Reports
Vitenskapelig artikkel
Schroer, Lisa; Weirich, Sara; Hammerstad, Marta; Hersleth, Hans-Petter; Grønsberg, Ida Andrietta; Hagen, Lars; Slupphaug, Geir; Malecki, Jedrzej Mieczyslaw; Jeltsch, Albert; Falnes, Pål. (2025) Orthologues of the human protein histidine methyltransferase METTL9 display distinct substrate specificities. Journal of Biological Chemistry
Vitenskapelig artikkel
Malecki, Jedrzej Mieczyslaw; Weirich, Sara; Ramirez, Manuel; Hagen, Lars; Al-Egly, Jakin Saad; Anonsen, Jan Haug; Schroer, Lisa; Herrera Gonzalez-Molina, Maria del Carmen; Davydova, Erna; Slupphaug, Geir. (2025) Identification of substrates and sequence requirements for CARNMT1-mediated histidine methylation of C3H zinc fingers. Journal of Biological Chemistry
Vitenskapelig artikkel
Rydning, Siri Lynne; Backe, Paul Hoff; Sousa, Mirta; Iqbal, Zafar; Øye, Ane-Marte; Sheng, Ying; Yang, Mingyi; Lin, Xiaolin; Slupphaug, Geir; Nordenmark, Tonje Haug. (2017) Corrigendum: Novel UCHL1 mutations reveal new insights into ubiquitin processing. Human Molecular Genetics
Korrigendum
Sousa, Mirta; Zub, Kamila Anna; Aas, Per Arne; Hanssen-Bauer, Audun; Demirovic, Aida; Sarno, Antonio; Tian, Erming; Liabakk, Nina-Beate; Slupphaug, Geir. (2013) An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. PLOS ONE
Vitenskapelig artikkel
Hu, Yi; Ericsson, Ida; Torseth, Kathrin; Methot, Stephen; Sundheim, Ottar; Liabakk, Nina-Beate; Slupphaug, Geir; Noia, Javier Di; Krokan, Hans Einar; Kavli, Bodil Merete. (2013) A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching. Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
Zhao, Chun-Mei; Rabben, Hanne-Line; Zhu, Yanping; Olsen, Magnus Kringstad; Wang, Zhiqiang; Hao, Yanpeng; Cai, Xing; Fonseca, Davi de Miranda; Sharma, Animesh; Li, Mingna. (2018) 390 - A New Treatment for Pancreatic Cancer: Targeting Nervecancer Cell Crosstalk. Gastroenterology
Konferanseabstract
Knaevelsrud, I; Knaevelsrud, I; Slupphaug, G; Leiros, Ingar; Matsuda, A; Ruoff, P; Ruoff, P; Bjelland, S; Bjelland, S. (2009) Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology
Vitenskapelig artikkel
Alves, Christiano R. R.; Eichelberger, Eric J.; Neves, Willian das; Ribeiro, Márcio A. C.; Bechara, Luiz R.G.; Voltarelli, Vanessa A.; Almeida, Ney R. de; Hagen, Lars; Sharma, Animesh; Ferreira, Julio C. B.. (2021) Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity. The FASEB Journal
Vitenskapelig artikkel
Slupphaug, Geir; Foss, Bjarne Anton. (2000) Nonlinear robust constrained control of partially uncontrollable and open-loop unstable systems. Journal of Process Control
Vitenskapelig artikkel
Slupphaug, Geir; Imsland, Lars Struen; Foss, Bjarne Anton. (2000) Uncertainty modelling and robust output feedback control of nonlinear discrete systems: a mathematical programming approach. International Journal of Robust and Nonlinear Control
Vitenskapelig artikkel
Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Skjelbred, Camilla Furu; Akbari, Mansour; Aas, Per Arne; Slupphaug, Geir. (2001) Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne; Foss, Bjarne Anton. (2001) Linear MPC with Optimal Prioritized Infeasibility Handling: Application, Computational Issues and Stability. Automatica
Vitenskapelig artikkel
Lysvand, Hilde; Hagen, Lars; Klubicka, Lidija; Slupphaug, Geir; Iversen, Ole-Jan. (2014) Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase. Biochimica et Biophysica Acta - Molecular Basis of Disease
Vitenskapelig artikkel
Johansen, Tor Arne; Slupphaug, Geir. (2000) Comment on "Stability issues on Takagi-Sugeno fuzzy model - parametric approach". IEEE transactions on fuzzy systems
Vitenskapelig artikkel
Zatula, Alexey; Dikic, Aida; Mulder, Teska Celine; Sharma, Animesh; Vågbø, Cathrine Broberg; Sousa, Mirta; Waage, Anders; Slupphaug, Geir. (2017) Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia. OncoTarget
Vitenskapelig artikkel
Steinacher, Roland; Barekati, Zeinab; Botev, Petar; Kusnierczyk, Anna; Slupphaug, Geir; Schär, Primo. (2019) SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation. EMBO Journal
Vitenskapelig artikkel
Schwarz, Simon D.; Xu, Jianming; Gunasekera, Kapila; Schürmann, David; Vågbø, Cathrine Broberg; Ferrari, Elena; Slupphaug, Geir; Hottiger, Michael O.; Schär, Primo; Steinacher, Roland. (2024) Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation. Nature Communications
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (2001) Efficient Optimal Prioritized Infeasibility Handling in Model Predictive Control - A Parametric Preemptive Multi-objective Linear Programming Approach. Journal of Optimization Theory and Applications
Vitenskapelig artikkel
Eftedal, Ingrid; Guddal, Per Henrik; Slupphaug, Geir; Volden, Gunnar; Krokan, Hans Einar. (1993) Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Iveland, Tobias Solli; Hagen, Lars; Sharma, Animesh; Sousa, Mirta; Sarno, Antonio; Wollen, Kristian Lied; Liabakk, Nina-Beate; Slupphaug, Geir. (2020) HDACi Mediate UNG2 Depletion, Dysregulated Genomic Uracil and Altered Expression of Oncoproteins and Tumor Suppressors in B- And T-cell Lines. Journal of Translational Medicine
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2006) Preface. DNA Repair
Vitenskapelig artikkel
Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel
Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna. (2016) Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice. Scientific Reports
Vitenskapelig artikkel
Hagen, Lars; Sharma, Animesh; Aas, Per Arne; Slupphaug, Geir. (2014) Off-target responses in the HeLa proteome subsequent to transient plasmid-mediated transfection. Biochimica et Biophysica Acta - Proteins and Proteomics
Vitenskapelig artikkel
Skarpengland, Tonje; Dahl, Tuva Børresdatter; Skjelland, Mona; Scheffler, Katja; Sousa, Mirta; Gregersen, Ida; Kusnierczyk, Anna; Sharma, Animesh; Slupphaug, Geir; Eide, Lars. (2016) Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA. Free Radical Biology & Medicine
Vitenskapelig artikkel
Monsen, Vivi A Talstad; Sundheim, Ottar; Aas, Per Arne; Westbye, Marianne Pedersen; Sousa, Mirta; Slupphaug, Geir; Krokan, Hans Einar. (2010) Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Eldin, Patrick; Péron, Sophie; Galashevskaya, Anastasia; Denis-Lagache, Nicolas; Cogné, Michel; Slupphaug, Geir; Briant, Laurence. (2020) Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination. Journal of Translational Medicine
Vitenskapelig artikkel
Brickner, Joshua R; Soll, Jennifer M; Lombardi, Patrick M; Vågbø, Cathrine Broberg; Mudge, Miranda C; Oyeniran, Clement; Rabe, Renana; Jackson, Jessica; Sullender, Meagan E; Blazosky, Elyse. (2017) A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature
Vitenskapelig artikkel
Andersen, S; Ericsson, M; DAI, H; Peña-Diaz, J; Slupphaug, G; Nilsen, Hilde; Aarset, H; Krokan, HE. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair
Vitenskapelig artikkel
Macur, Katarzyna; Hagen, Lars; Ciesielski, Tomasz Maciej; Konieczna, Lucyna; Skokowski, Jaroslaw; Jenssen, Bjørn Munro; Slupphaug, Geir; Baczek, Tomasz. (2019) A targeted mass spectrometry immunoassay to quantify osteopontin in fresh-frozen breast tumors and adjacent normal breast tissues. Journal of Proteomics
Vitenskapelig artikkel
Sundheim, Ottar; Talstad, Vivi A; Vågbø, Cathrine Broberg; Slupphaug, Geir; Krokan, Hans Einar. (2008) AlkB demethylases flip out in different ways. DNA Repair
Vitenskapelig artikkel
Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry
Vitenskapelig artikkel
Visnes, Torkild; Akbari, Mansour; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2008) The rate of base excision repair of uracil is controlled by the initiating glycosylase. DNA Repair
Vitenskapelig artikkel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel. Data in Brief
Vitenskapelig artikkel
Sousa, Mirta; Krokan, Hans Einar; Slupphaug, Geir. (2007) DNA-uracil and human pathology. Molecular Aspects of Medicine
Vitenskapelig oversiktsartikkel
Lysvand, Hilde; Helland, Ronny; Hagen, Lars; Slupphaug, Geir; Iversen, Ole-Jan. (2015) Psoriasis pathogenesis – Pso p27 constitutes a compact structure forming large aggregates. Biochemistry and Biophysics Reports
Vitenskapelig artikkel
Slupphaug, Geir. (2016) Modulering av cellulær metabolisme bidrar til Melfalan-resistens i myelomaotse. Best Practice Onkologi/Hematologi
Fagartikkel
Krokan, Hans Einar; Standal, Rune; Slupphaug, Geir. (1997) DNA glycosylase in the base excision repair of DNA. Biochemical Journal
Vitenskapelig artikkel
Vågbø, Cathrine Broberg; Slupphaug, Geir. (2020) RNA in DNA repair. DNA Repair
Vitenskapelig artikkel
Johannessen, Helene; Kodama, Yosuke; Zhao, Chun-Mei; Sousa, Mirta; Slupphaug, Geir; Kulseng, Bård Eirik; Chen, Duan. (2012) Eating Behavior and Glucagon-Like Peptide-1-Producing Cells in Interposed Ileum and Pancreatic Islets in Rats Subjected to Ileal Interposition Associated with Sleeve Gastrectomy. Obesity Surgery
Vitenskapelig artikkel
Yang, Rui; Elsaadi, Samah; Misund, Kristine; Abdollahi, Pegah; Vandsemb, Esten; Moen, Siv Helen; Kusnierczyk, Anna; Slupphaug, Geir; Standal, Therese; Waage, Anders. (2020) Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade. Journal for ImmunoTherapy of Cancer (JITC)
Vitenskapelig artikkel
Olinski, Ryszard; Slupphaug, Geir; Foksinski, Marek; Krokan, Hans Einar. (2021) Genomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignancies. International Journal of Molecular Sciences
Vitenskapelig artikkel
Mjelle, Robin; Hegre, Siv Anita; Aas, Per Arne; Slupphaug, Geir; Drabløs, Finn; Sætrom, Pål; Krokan, Hans Einar. (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair
Vitenskapelig artikkel
Kavli, Bodil Merete; Iveland, Tobias Solli; Buchinger, Edith; Hagen, Lars; Liabakk, Nina-Beate; Aas, Per Arne; Obermann, Tobias Sebastian; Aachmann, Finn Lillelund; Slupphaug, Geir. (2021) RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Vasuthas, Kalaiyarasi; Christiansen, Sverre Christian; Kjesbu, Joachim Sebastian; Ryan, Liv; Andreassen, Trygve; Slupphaug, Geir; Strand, Berit Løkensgard; Stenvik, Jørgen; Rokstad, Anne Mari A.. (2025) Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences. Materials Today Bio
Vitenskapelig artikkel
Slupphaug, Geir; Eftedal, Ingrid; Kavli, Bodil; Bharati, Sangeeta; Helle, Nils M; Haug, Terje; Levine, David William; Krokan, Hans Einar. (1995) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry
Vitenskapelig artikkel
Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja; Neurauter, Christine Gran; Esbensen, Qin Ying; Kusnierczyk, Anna; Hildrestrand, Gunn Annette; Graupner, Anne. (2017) No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Scientific Reports
Vitenskapelig artikkel
Slupphaug, G.; Markussen, F.-H.; Olsen, Lisbeth Charlotte; Aasland, Rein; Aarsæther, Niels; Bakke, O.; Krokan, H. E.; Helland, Dag Emil. (1993) Human Uracil-DNA glycosylase is shared by the nucleus and the mitochondria. Nucleic Acid Res
Vitenskapelig artikkel
Slupphaug, Geir; Foss, Bjarne Anton. (1999) Constrained quadratic stabilization of discrete-time uncertain non-linear multi-model systems using piecewise affine state-feedback. International Journal of Control
Vitenskapelig artikkel
Baglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda; Zub, Kamila; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Photochemical and Photobiological Sciences
Vitenskapelig artikkel
Hagen, Lars; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2006) Genomic uracil and human disease. Experimental Cell Research
Vitenskapelig oversiktsartikkel
Iversen, Ole-Jan; Lysvand, Hilde; Slupphaug, Geir. (2016) Pso p27, a SERPINB3/B4-derived protein, is most likely a common autoantigen in chronic inflammatory diseases. Clinical Immunology
Vitenskapelig artikkel
Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars. (2015) Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports
Vitenskapelig artikkel
Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) Uracil in DNA - General mutagen, but normal intermediate in acquired immunity. DNA Repair
Vitenskapelig artikkel
Krokan, Hans Einar; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Kavli, Bodil Merete; Slupphaug, Geir. (2014) Error-free versus mutagenic processing of genomic uracil-Relevance to cancer. DNA Repair
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA- from molecular biology to phenotype. DNA Repair
Konferanseabstract
Slupphaug, G.; Olsen, Lisbeth Charlotte; Helland, Dag Emil; Aasland, Rein; Krokan, H. E.. (1991) Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil- DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Akbari, Mansour; Visnes, Torkild; Pettersen, Henrik P Sahlin; Sundheim, Ottar; Hagen, Lars; Otterlei, Marit; Gilljam, Karin Margaretha; Slupphaug, Geir. (2007) Repair og uracil in DNA by UNG2 and SMUG1 - an update. DNA Repair
Konferanseabstract
Parsons, Jason L.; Kavli, Bodil Merete; Slupphaug, Geir; Dianov, Grigory L.. (2007) NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break. Biochemistry
Vitenskapelig artikkel
Helander, Linda; Sharma, Animesh; Krokan, Hans Einar; Plaetzer, Kristjan; Krammer, Barbara; Tortik, Nicole; Gederaas, Odrun Arna; Slupphaug, Geir; Hagen, Lars. (2016) Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins. Molecular Biosystems
Vitenskapelig artikkel
Pettersen, Henrik P Sahlin; Sundheim, Ottar; Gilljam, Karin Margaretha; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2007) Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Lu, CC; Huang, HT; Wang, JT; Slupphaug, Geir; Li, TK; Wu, MC; Chen, YC; Lee, CP; Chen, MR. (2007) Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication. Journal of Virology
Vitenskapelig artikkel
Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bhariti, Sangeeta; Steinsbekk, Kristin; Nilsen, Hilde; Skjelbred, Camilla; Kavli, Bodil; Standal, Rune; Slupphaug, Geir. (1999) Human uracil-DNA glycosylase. NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
Alves, Christiano R. R.; Neves, Willian des; Almeida, Ney R de; Eichelberger, Eric J; Jannig, Paulo R.; Voltarelli, Vanessa A; Tobias, Gabriel C; Bechara, Luiz R G; Faria, Daniele de Paula; Alves, Maria J N. (2020) Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN. Molecular Metabolism
Vitenskapelig artikkel
Dizdaroglu, Miral; Karakaya, Asuman; Jaruga, Pawel; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Slupphaug, Geir; Mol, Clifford D.; Kavli, Bodil; Arvai, Andrew S.; Krokan, Hans Einar; Tainer, John A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature
Vitenskapelig artikkel
Knævelsrud, I.; Slupphaug, Geir; Leiros, Ingar; Matsuda, A.; Ruoff, Peter; Bjelland, Svein. (2009) Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology
Vitenskapelig artikkel
Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo; Bianco Nascimento Moreira, Jose; Alves, Marcia Netto Magalhaes; Wohlwend, Martin; Gebriel, Mohammed; Hagen, Lars. (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Scientific Reports
Vitenskapelig artikkel
Hayran , Abdul Baset ; Liabakk, Nina-Beate; Aas, Per Arne; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Sarno, Antonio; Iveland, Tobias Solli; Chawla, Konika; Zahn, Astrid; DiNoia, Javier M. (2023) RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Wang, Qiong; Karvelsson, Sigurdur Trausti; Johannsson, Freyr; Vilhjalmsson, Arnar Ingi; Hagen, Lars; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Rolfsson, Ottar. (2021) UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines. Molecular Oncology
Vitenskapelig artikkel
Kavli, Bodil; Slupphaug, Geir; Mol, Clifford D.; Arvai, Andrew S.; Petersen, Steffen B.; Tainer, John A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Krokan, Hans Einar; Parikh, S.S.; Slupphaug, Geir; Bharati, S; Trainer, J.A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO Journal
Vitenskapelig artikkel
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Parikh, Sudip S.; Walcher, Gunter; Jones, Garry D.; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.Michael; Tainer, John A.. (2000) Uracil-DNA glycosylase-DNA substrate and product structures:Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Berrocal, Marion Silvana Fernandez; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna. (2021) NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. Communications Biology
Vitenskapelig artikkel
Rydning, Siri Lynne; Backe, Paul Hoff; Sousa, Mirta; Iqbal, Zafar; Øye, Ane-Marte; Sheng, Ying; Yang, Mingyi; Lin, Xiaolin; Slupphaug, Geir; Nordenmark, Tonje Haug. (2017) Novel UCHL1 mutations reveal new insights into ubiquitin processing. Human Molecular Genetics
Vitenskapelig artikkel
Sousa, Mirta; Steen, Kristian Wollen; Hagen, Lars; Slupphaug, Geir. (2011) Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis. Proteome Science
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, Hilde; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters
Vitenskapelig artikkel
Johnsen, Anne Berit; Rolim, Natale Pinheiro Lage; Stølen, Tomas; Alves, Marcia; Sousa, Mirta; Slupphaug, Geir; Britton, Steven L; Koch, Lauren G; Smith, Godfrey L; Wisløff, Ulrik. (2013) Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity. PLOS ONE
Vitenskapelig artikkel
Bharati, S.; Krokan, Hans Einar; Kristiansen, L; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Gederaas, Odrun Arna; Sharma, Animesh; Mbarak, Saide; Sporsheim, Bjørnar; Høgset, Anders; Bogoeva, Vanya; Slupphaug, Geir; Hagen, Lars. (2023) Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells. Molecular Omics
Vitenskapelig artikkel
Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Alswady-Hoff, Mayes; Erdem, Johanna Maria Samulin; Phuyal, Santosh; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Skare, Øivind; Slupphaug, Geir; Zienolddiny, Shanbeh. (2021) Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells. International Journal of Molecular Sciences
Vitenskapelig artikkel
Waldum, Helge; Slupphaug, Geir. (2024) Correctly identifying the cells of origin is essential for tailoring treatment and understanding the emergence of cancer stem cells and late metastases. Frontiers in Oncology
Vitenskapelig oversiktsartikkel
Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Abdollahi, Pegah; Vansemb, Esten; Hagen, Lars; Baranowska, Katarzyna Anna; Misund, Kristine; Slupphaug, Geir; Børset, Magne. (2014) PRL-3 Mediates Survival of Primary Myeloma Cells. Blood
Konferanseabstract
Nilsen, Hilde; Rosewell, I.; Robins, P.; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Krokan, Hans Einar; Lindahl, T.; Barnes, D.E.. (2000) ) Ung-deficient mice reveal a primary role of the uracil-DNA glycosylase enzyme during DNA replication. Molecular Cell
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, H.; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair in mammalian cells. FEBS Letters
Vitenskapelig artikkel
Iveland, Tobias Solli; Hagen, Lars; Sousa, Mirta; Liabakk, Nina-Beate; Aas, Per Arne; Sharma, Animesh; Kavli, Bodil Merete; Slupphaug, Geir. (2025) Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA. Scientific Reports
Vitenskapelig artikkel
Buchinger, Edith; Wiik, Siv Åshild; Kusnierczyk, Anna; Rabe, Renana; Aas, Per Arne; Kavli, Bodil Merete; Slupphaug, Geir; Aachmann, Finn Lillelund. (2017) Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2. Biomolecular NMR Assignments
Vitenskapelig artikkel
Slupphaug, Geir; Alseth, Ingrun; Eftedal, Ingrid; Volden, Gunnar; Krokan, Hans Einar. (1993) Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification. Analytical Biochemistry
Vitenskapelig artikkel
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Parikh, S; Walcher, G; Jones, G.D; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.M; Tainer, J.A. (2000) Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Mittelstedt, L.Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO Journal
Vitenskapelig artikkel
Diaz, Javier Pena; Akbari, Mansour; Sundheim, Ottar; Farez-Vidal, ME; Andersen, S; Sneve, R; Gonzalez-Pacanowska, D; Krokan, Hans Einar; Slupphaug, Geir. (2004) Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair. Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Aas, Per Arne; Kavli, Bodil; Liabakk, Nina-Beate; Hagen, Lars; Imai, K; Durandy, A; Slupphaug, Geir. (2004) Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Kataya, Amr Ramzy Abass; Ahootapeh, Behzad Heidari; Hagen, Lars; Kommedal, Roald; Slupphaug, Geir; Lillo, Cathrine. (2014) Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Plant Physiology
Vitenskapelig artikkel
Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål. (2015) AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA Repair
Vitenskapelig artikkel
Iveland, Tobias S.; Hagen, Lars; Sharma, Animesh; Sousa, Mirta M. L.; Sarno, Antonio; Wollen, Kristian Lied; Liabakk, Nina-Beate; Slupphaug, Geir. (2021) Correction to: HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines (Journal of Translational Medicine, (2020), 18, 1, (159), 10.1186/s12967-020-02318-8). Journal of Translational Medicine
Korrigendum
Johansen, Tor Arne; Petersen, Idar; Slupphaug, Geir. (2002) Explicit sub-optimal linear quadratic regulation with state and input constraints. Automatica
Vitenskapelig artikkel
Thangstad, Ole Petter; Iversen, Tor-Henning; Slupphaug, Geir; Bones, Atle M.. (1990) Immunocytochemical localization of myrosinase. Planta
Vitenskapelig artikkel
Langevin, C; Maidou-Peindara, P; Aas, Per Arne; Jacquot, G; Otterlei, Marit; Slupphaug, Geir; Benichou, S. (2009) Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect. Journal of Virology
Vitenskapelig artikkel
Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Ericsson, Ida; Galashevskaya, Anastasia; Sarno, Antonio; Aas, Per Arne; Vagbo, CB; Pettersen, Henrik P Sahlin; Slupphaug, Geir. (2013) Genomic uracil - potent mutagen but normal intermediate in adaptive immunity. The FEBS Journal
Konferanseabstract
Zub, Kamila; Sousa, Mirta; Sarno, Antonio; Sharma, Animesh; Dikic, Aida; Rao, Shalini; Young, Clifford; Aas, Per Arne; Ericsson, Ida; Sundan, Anders. (2015) Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired Melphalan resistance in multiple myeloma cells. PLOS ONE
Vitenskapelig artikkel
Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi; Lång, Anna Ulrika; Kristiansen, Elise; Pannone, Marco; Kissova, Miroslava. (2023) A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment. Genome Biology
Vitenskapelig artikkel
Krokan, Hans Einar; Akbari, Mansour; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Ericsson, Madelene; Aarset, Harald; Andersen, Sonja Benedikte; Slupphaug, Geir. (2006) Base excision repair proteins in cancer prevention and acquired immune responses. The FEBS Journal
Konferanseabstract
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA - From molecular biology to phenotype - Preface. DNA Repair
Leder
Kavli, Bodil Merete; Andersen, Sonja Benedikte; Otterlei, Marit; Liabakk, Nina-Beate; Imai, K; Fischer, A; Durandy, A; Krokan, Hans Einar; Slupphaug, Geir. (2005) B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
Andersen, Sonja Benedikte; Ericsson, Maria Elisabeth Madelene; Dai, HY; Diaz, Javier Pena; Slupphaug, Geir; Nilsen, H; Aarset, H; Krokan, Hans Einar. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair
Vitenskapelig artikkel
Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair
Vitenskapelig oversiktsartikkel
Bergstrøm, Bjarte Aune; Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit Walbye. (2010) Identification of a Novel in Vivo Virus-targeted Phosphorylation Site in Interferon Regulatory Factor-3 (IRF3). Journal of Biological Chemistry
Vitenskapelig artikkel
Slupphaug, Geir; Kavli, Bodil; Krokan, Hans Einar. (2003) Interacting pathways that prevent and repair oxidative DNA damage. Mutation Research (DNA Repair)
Vitenskapelig artikkel
Imai, K; Slupphaug, Geir; Lee, W-I; Revy, P; Nonoyama, S; Catalan, N; Yel, L; Forveille, M; Kavli, Bodil; Krokan, Hans Einar. (2003) Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch. Nature Immunology
Vitenskapelig artikkel
Zeitlin, SG; Patel, S; Kavli, Bodil Merete; Slupphaug, Geir. (2005) Xenopus CENP - A assembly into chromatin requires base excision repair proteins. DNA Repair
Vitenskapelig artikkel
Phuyal, Santosh; Kasem, Mayes; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Vebraite, Vaineta; Shaposhnikov, Sergey; Slupphaug, Geir; Skaug, Vidar; Zienolddiny, Shanbeh. (2018) Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes. Nanotoxicology
Vitenskapelig artikkel
Hanssen-Bauer, Audun; Garten, Karin Solvang-; Sundheim, Ottar; Diaz, Javier Pena; Andersen, Sonja Benedikte; Slupphaug, Geir; Krokan, Hans Einar; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2011) XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage. Environmental and Molecular Mutagenesis
Vitenskapelig artikkel
Zeitlin, SG; Chapados, BR; Baker, NM; Tai, C; Slupphaug, Geir; Wang, JYJ. (2011) Uracil DNA N-Glycosylase Promotes Assembly of Human Centromere Protein A. PLOS ONE
Vitenskapelig artikkel
Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein. (2017) NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports
Vitenskapelig artikkel
Felberg, Hanne Solvang; Hagen, Lars; Slupphaug, Geir; Batista, Irineu; Nunes, Maria Leonora; Olsen, Ragnar Ludvig; Martinez, iciar. (2010) Partial characterisation of gelatinolytic activities in herring (Clupea harengus) and sardine (Sardina pilchardus) possibly involved in post-mortem autolysis of ventral muscle. Food Chemistry
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2004) Novel aspects of macromolecular repair and relationship to human disease. Journal of Molecular Medicine
Vitenskapelig oversiktsartikkel
Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature
Vitenskapelig artikkel
Doseth, Berit; Visnes, Torkild; Wallenius, Anders; Ericsson, Ida; Sarno, Antonio; Pettersen, Henrik Sahlin; Flatberg, Arnar; Catterall, Tara Cherie; Slupphaug, Geir; Krokan, Hans Einar. (2011) Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE. Journal of Biological Chemistry
Vitenskapelig artikkel
Nilsen, Hilde; Rosewell, Ian; Robins, Peter; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Daly, Graham; Krokan, Hans Einar; Lindahl, Tomas; Barnes, Deborah E.. (2000) URACIL-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication. Molecular Cell
Vitenskapelig artikkel
Otterlei, Marit; Warbrick, Emma; Nagelhus, Toril; Haug, Terje; Slupphaug, Geir; Akbari, Mansour; Aas, Per Arne; Steinsbekk, Kristin; Bakke, Oddmund; Krokan, Hans Einar. (1999) Post-replicative base excision repair in replication foci. EMBO Journal
Vitenskapelig artikkel
Torseth, Kathrin; Doseth, Berit; Hagen, Lars; Olaisen, Camilla; Liabakk, Nina-Beate; Græsmann, Heidi; Durandy, Anne; Otterlei, Marit; Krokan, Hans Einar; Kavli, Bodil Merete. (2012) The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA. DNA Repair
Vitenskapelig artikkel
Doseth, Berit; Ekre, Cecilie; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2012) Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil. DNA Repair
Vitenskapelig artikkel
Roberts, Victoria A.; Pique, Michael E.; Hsu, Simon; Li, Sheng; Slupphaug, Geir; Rambo, Robert P.; Jamison, Jonathan P.; Liu, Tong; Lee, Jun H.; Tainer, John A.. (2012) Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Parikh, S. Sudip; Mol, Clifford D.; Slupphaug, Geir; Bharati, Sangeta; Krokan, Hans Einar; Yainer, John A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Otterlei, Marit; Haug, T.; Nagelhus, T.A; Slupphaug, Geir; Lindmo, T.; Krokan, Hans Einar. (1998) Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (1998) DNA-reparasjonsenzymer og deres gener. Tidsskrift for Den norske legeforening (Tidsskriftet)
Vitenskapelig artikkel
Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2022) MS-proteomics provides insight into the host responses towards alginate microspheres. Materials Today Bio
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Otterlei, Marit; Akbari, M.; Slupphaug, Geir; Aas, Per Arne. (2010) DNA repair and cancer. European Journal of Cancer
Konferanseabstract
Cappelli, E.; Hazra, T.; Hill, J.; Slupphaug, Geir; Bobliolo, M.; Frosina, G.. (2001) Rates of base excision repair are not solely dependent on levels of initiating enzymes. Carcinogenesis
Vitenskapelig artikkel
Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Liabakk, Nina-Beate; Sundheim, Ottar; Diaz, Javier Pena; Otterlei, Marit; Hørning, Ole; Jensen, Ole N. (2008) Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO Journal
Vitenskapelig artikkel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay. Analytical Biochemistry
Vitenskapelig artikkel
Vasuthas, Kalaiyarasi; Kjesbu, Joachim Sebastian; Brambilla, Alessandro; Levitan, Maya; Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Strand, Berit Løkensgard; Slupphaug, Geir; Rokstad, Anne Mari A.. (2025) Fucoidan alginate and sulfated alginate microbeads induce distinct coagulation, inflammatory and fibrotic responses. Materials Today Bio
Vitenskapelig artikkel
Nagelhus, T.; Slupphaug, Geir; Krokan, Hans Einar; Lindmo, T.. (1996) Fading correction for fluorescence quantitation in confocal microscopy. Cytometry
Vitenskapelig artikkel
Bouhamdan, M; Benichou, S.; Rey, F.; Navarro, J.M.; Agostini, I.; Spire, B.; Camanis, G.; Slupphaug, Geir; Vigne, R; Benarous, R. (1996) Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme. Journal of Virology
Vitenskapelig artikkel
Kavli, B.; Slupphaug, Geir; Mol, C.D.; Arvai, A.S.; Petersen, S.B.; Tainer, J.A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Steen, Kristian Wollen; Doseth, Berit; Westbye, Marianne Pedersen; Akbari, Mansour; Kang, D; Falkenberg, Maria; Slupphaug, Geir. (2012) mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored. DNA Repair
Vitenskapelig artikkel
Slupphaug, Geir; Kavli, B.; Mol, C.D.; Arvai, A.; Krokan, Hans Einar; Tainer, J.A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature
Vitenskapelig artikkel
Dizdaroglu, M.; Karakaya, A.; Jaruga, P.; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Pinto, Rita; Vågbø, Cathrine Broberg; Jakobsson, Magnus; Yeji, Kim; Baltissen, Marijke P; O'Donohue, Marie-Francoise; Guzman, Ulises H; Malecki, Jedrzej Mieczyslaw; Wu, Jie; Kirpekar, Finn. (2019) The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Galashevskaya, Anastasia; Sarno, Antonio; Vågbø, Cathrine Broberg; Aas, Per Arne; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2013) A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported. DNA Repair
Vitenskapelig artikkel
Steen, Kristian Wollen; Hagen, Lars; Vågbø, Cathrine Broberg; Rabe, Renana; Iveland, Tobias Solli; Aas, Per Arne; Sharma, Animesh; Sporsheim, Bjørnar; Erlandsen, Hilde; Palibrk, Vuk. (2021) ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA. Journal of Translational Medicine
Vitenskapelig artikkel
Berg, Sigrid Ravn; Demirovic, Aida; Sharma, Animesh; Hagen, Lars; Vågbø, Cathrine Broberg; Zatula, Alexey; Misund, Kristine; Waage, Anders; Slupphaug, Geir. (2024) Progression of monoclonal gammopathy of undetermined significance to multiple myeloma is associated with enhanced translational quality control and overall loss of surface antigens. Journal of Translational Medicine
Vitenskapelig artikkel
Rolim, Natale Pinheiro Lage; Skårdal, Kristine; Høydal, Morten; Sousa, Mirta; Malmo, Vegard; Skrove, Guri Kaurstad; Ingul, Charlotte Bjørk; Hansen, Harald Edvard Mølmen; Alves, Marcia Netto Magalhaes; Thuen, Marte. (2015) Aerobic interval training reduces inducible ventricular arrhytmias in diabetic mice after myocardial infarction. Basic Research in Cardiology
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2002) Damage and repair of DNA in mammalian cells-emphasis on oxidative damage. Proceedings from International Symposium "Natural Ionising Radiation and Health". Det Norske Videnskaps-Akademi : proceedings
Vitenskapelig artikkel
Krokan, Hans Einar; Drabløs, Finn; Slupphaug, Geir. (2002) Uracil in DNA, occurrence, consequences and repair. Oncogene
Vitenskapelig artikkel
Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Skorpen, Frank; Aas, Per Arne; Hagen, Lars; Krokan, Hans Einar; Slupphaug, Geir. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry
Vitenskapelig artikkel
Kataya, Amr Ramzy Abass; Heidari, Behzad; Hagen, Lars; Kommedal, Roald; Slupphaug, Geir; Lillo, Cathrine. (2015) Supplemental materials for: Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Plant Physiology
Vitenskapelig artikkel
Visnes, Torkild; Doseth, Berit; Pettersen, Henrik Sahlin; Hagen, Lars; Sousa, Mirta; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2009) Uracil in DNA and its processing by different DNA glycosylases. Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel

Bøker

Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil - Evolution, Biology, Immunology and Disease. World Scientific
Faglig monografi
Iversen, Tor-Henning; Bones, Atle M.; Slupphaug, Geir. (1993) Bioteknologi - 2 timers valgfag. Gyldendal Akademisk
Faglig monografi

Del av bok/rapport

Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2020) Genomic Uracil in Biology, Immunity and Cancer.
Vitenskapelig kapittel
Krokan, Hans Einar; Standal, Rune; Bharati, Sangeeta; Otterlei, Marit; Haug, Terje; Slupphaug, Geir; Skorpen, Frank. (1997) Uracil in DNA and the family of concerved uracil DNA glycosylases.
Vitenskapelig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Sarno, Antonio; Slupphaug, Geir. (2018) Enzymology of Genomic Uracil Repair.
Faglig kapittel
Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil – Valuable Tool in Molecular Biology but Inherent Problem in Sequencing of Ancient DNA.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir; Drabløs, Finn. (2018) The Earth, Life and Genomic Uracil.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) DNA Repair is Integrated with Many Cellular Processes.
Faglig kapittel
Kavli, Bodil Merete; Slupphaug, Geir. (2018) Genomic Uracil and Immunity.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) Viral Uracil - Uracil DNA glycosylases and dUTPases.
Faglig kapittel
Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2018) Routes to Uracil in DNA.
Faglig kapittel
Krokan, Hans Einar; Slupphaug, Geir; Kavli, Bodil Merete. (2017) Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig kapittel

Rapport

Slupphaug, Geir. (1995) A note on hybrid systems emphasizing approaches in the control community. Norges tekniske høgskole. Institutt for teknisk kybernetikk
Forskningsrapport
Slupphaug, Geir. (1995) A brief introduction to some logics, formal languages and Petri net theory. Norges tekniske høgskole. Institutt for teknisk kybernetikk
Forskningsrapport
Slupphaug, Geir; Halvorsen, Ivar. (1995) Forprosjekt: Regulering og overvåking av komplekse industrianlegg. NTH. Institutt for teknisk kybernetikk
Forskningsrapport
Imsland, Lars Struen; Slupphaug, Geir; Foss, Bjarne Anton. (2000) Robust output feedback control for constrained discrete-time nonlinear systems using observer-based controllers. ITK
Forskningsrapport
Slupphaug, Geir; Foss, Bjarne Anton. (1996) Model predictive control for a class of hybrid systems. NTNU. Inst. f. teknisk kybernetikk
Forskningsrapport
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (1999) Efficient optimal prioritized infeasibility handling in model predictive control - a parametric preemptive multi-objective linear programming approach. Institutt for teknisk kybernetikk, NTNU
Forskningsrapport

Studentoppgave eller avhandling

Sterten, Heidi; Krøkje, Åse; Otterlei, Marit; Slupphaug, Geir. (2007) Ekspresjon, rensing og funksjonelle studier av rekombinant humant replikasjonsprotein A (RPA). NTNU
Masteroppgave
Azizyan, Mahnaz; Anthonsen, Thorleif; Slupphaug, Geir. (2007) Studier av human mitokondriell uracil-DNA glukosylase UNG1. NTNU
Masteroppgave
Grøsvik, K; Slupphaug, Geir; Krokan, Hans Einar. (2002) "Characterisation of uracil-exising enzyme activities in organ extracts from UNG knockout and wild-type mice.". NTNU
Masteroppgave
Nygård, M; Nilsen, M; Remseth, V; Slupphaug, Geir; Krokan, Hans Einar. (2002) Uttrykk av det membran-modifiserende enzymet UDPDG i E.coli som funksjon av dyrkningsbetingelser og induksjon av DNA-skader. [Mangler utgivernavn]
Masteroppgave
Slupphaug, Geir. (1998) On robust constrained nonlinear control and hybrid control : BMI and MPC based state-feedback schemes. Institutt for teknisk kybernetikk, NTNU
Doktoravhandling
Fensgård, Øyvind; Bones, Atle M; Slupphaug, Geir. (2005) Separation of UNG-associated repair protein complexes using gradient centrifugation techniques. Norwegian University of Science and Technology
Masteroppgave
Brenne, Wenche; Slupphaug, Geir. (1994) Immunologiske studier av humant uracil-DNA glycosylase. Universitetet i Trondheim
Masteroppgave
Baglo, Yan; Gederaas, Odrun Arna; Slupphaug, Geir. (2010) Effects of Photodynamic Therapy on Protein Expression in Rat Bladder Cancer Cells. NTNU-trykk
Masteroppgave

Undervisning

Emner

MOL4901 - Masteroppgave i nanoteknologi

Formidling

2024

Konferanseforedrag

Gederaas, Odrun; Dahl, H; Lindgren, Mikael; Stigen, K; Høgset, Anders; Hirschberg, H; Slupphaug, Geir; Sharma, Animesh; Hagen, Lars. (2024) Photochemical internalization with fimaporfin; a summary of in vitro and in vivo models. Photodynamic Therapy & Photodiagnosis Update 2024
Foredrag

Slupphaug, Geir. (2024) Nobelprisen i medisin 2023 og veien frem til effektive mRNA vaksiner. Seminar, Gløshaugen Akademiske Club
Foredrag

Slupphaug, Geir. (2024) The Nobel Prize in Medicine 2023 and the Path to Effective mRNA Vaccines. Seminar, IBT, NTNU
Konferanseposter

Sharma, Animesh; Kuśnierczyk, Anna; Vågbø, Cathrine Broberg; Fonseca, Davi de Miranda; Slupphaug, Geir; Hagen, Lars. (2024) PROMEC-Services within Proteomics and DNA/RNA-modomics. Research Day 2024

2023

Foredrag

Brambilla, Alessandro; Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2023) MS-proteomics provides insight into the host responses towards alginate microspheres. A HEALTHY FUTURE
Konferanseposter

Ragunathan, Kalaiyarasi; Brambilla, Alessandro; Kjesbu, Joachim Sebastian; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2023) The initial host response to alginate-based microbeads in human whole blood depict by functional response and mass spectrometry. ScSB meeting - Bioinspiration in biomaterials
Konferanseposter

Ragunathan, Kalaiyarasi; Brambilla, Alessandro; Kjesbu, Joachim Sebastian; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2023) Exploring Immunogenicity of Sulphated Alginate Beads: Insights from Whole Blood Model and Protein Adsorption Analysis. A HEALTHY FUTURE
Konferanseposter

Coron, Abba Elizabeth; Kjesbu, Joachim Sebastian; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2023) MS-based proteomic profiling of alginate microspheres relevant for cell therapy. ScSB meeting - Bioinspiration in biomaterials

2022

Konferanseforedrag

Eldin, Patrick; Vågbø, Cathrine Broberg; Salinas, Sara; Hagiwara, Masatoshi; Slupphaug, Geir; Briant, Laurence. (2022) Le virus Zika reprogramme l'epitranscriptome des ARNt de l'hote pour l'adapter a son biais des codons et faciliter sa traduction. XXIVème Journées Francophones de Virologie
Konferanseforedrag

Slupphaug, Geir; Dikic, Aida; Berg, Sigrid Karlsen; Sharma, Animesh; Hagen, Lars; Vågbø, Cathrine Broberg. (2022) Enhanced protein translation fidelity – a novel target in multiple myeloma treatment?. 8th International Caparica Conference on Analytical Proteomics 2022

2019

Konferanseforedrag

Slupphaug, Geir. (2019) Selective removal of aberrant mRNA methylation may counteract “epitranscriptome confusion”. 18th annual Workshop on Structural Biology of DNA Repair (SBDR), Marshall, California
Konferanseposter

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Rokstad, Anne Mari A.; Strand, Berit Løkensgard. (2019) Elucidating host responses towards alginate microspheres using proteomics. Scandinavian Society for Biomaterials 2019 Conference
Foredrag

Slupphaug, Geir. (2019) Experiences from sabbatical at Berkeley 2019 – scientific and beyond. IKOM onsdagsforedrag

2018

Konferanseposter

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari. (2018) Identification of adsorbing human plasma proteins on alginate gel beads. BRG Capsule workshop 2018
Konferanseposter

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari. (2018) Identification of adsorbing human plasma proteins on alginate gel beads. Nordic Proteomics Conference
Foredrag

Slupphaug, Geir. (2018) Endringer i genomet kontra endringer i proteomet- Hvordan kan proteomanalyser komplementere genetiske analyser?. Seminarserie-medisinsk Genetikk, St Olavs Hospital
Konferanseposter

Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Slupphaug, Geir. (2018) DNA and RNA modification profiling using liquid chromatography – mass spectrometry. EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice
Konferanseforedrag

Slupphaug, Geir. (2018) Selective removal of aberrantly methylated mRNA bases may avoid “epitranscriptome confusion”. Onsdagsforedrag IKOM
Konferanseposter

Slupphaug, Geir; Steen, Kristian Wollen; Rabe, Renana; Hagen, Lars; Aas, Per Arne; Sharma, Animesh; Vuk, Palibrk; Bjørås, Magnar; Mosammaparast, Nima; Fonseca, Davi de Miranda. (2018) A role of ASCC3 in the quality control of methylated mRNA. EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice
Konferanseposter

Yang, Rui; Elsaadi, Samah; Misund, Kristine; Slupphaug, Geir; Menu, Eline; Hay, Carl; Cooper, Zac; Vanderkerken, Karin; Børset, Magne; Sponaas, Anne-Marit. (2018) Role of ectoenzymes CD39 and CD73 in the immune response to multiple myeloma. Annual Meeting of the American Association for Cancer Research

2017

Konferanseposter

Gederaas, Odrun Arna; Sharma, Animesh; Bogoeva, Vanya; Mbarak, Saide; Kanamazina, Yusuf; Sporsheim, Bjørnar; Høgset, Anders; Slupphaug, Geir; Hagen, Lars. (2017) The proteome of endosomes after Bleomycine-mediated photochemical internalization on rat bladder cancer cells. 16th International Photodynamic Association World Congress

2016

Konferanseforedrag

Krokan, Hans Einar; Kavli, Bodil Merete; Pettersen, Henrik Sahlin; Sætrom, Pål; Galashevskaya, Anastasia; Sarno, Antonio; Aas, Per Arne; Doseth, Berit; Slupphaug, Geir. (2016) Genomic Uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan
Konferanseforedrag

Slupphaug, Geir; Steen, Kristian Wollen; Hagen, Lars; Aas, Per Arne; Sharma, Animesh; Vågbø, Cathrine Broberg; Palibrk, Vuk; Bjørås, Magnar; Fonseca, Davi de Miranda. (2016) MMS-induced modifications in mRNA and potential roles of ASCC3/ALKBH3. The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan
Konferanseposter

Sharma, Animesh; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Fonseca, Davi de Miranda; Slupphaug, Geir. (2016) PROMEC: Services within Proteomics and DNA/RNA-modomics. Seminar for staff at the future Faculty of Medicine and Health Sciences
Konferanseforedrag

Krokan, Hans Einar; Pettersen, Henrik Sahlin; Mjelle, Robin; Hegre, Siv Anita; Sætrom, Pål; Drabløs, Finn Sverre; Sarno, Antonio; Galashevskaya, Anastasia; Aas, Per Arne; Liabakk, Nina-Beate. (2016) REGULATION OF BASE EXCISION REPAIR – CANONICAL AND NON-CANONICAL PROCESSING OF GENOMIC URACIL. 10th International Multiconference on Bioinformatics of Genome Regulation and Structure\Systems Biology
Konferanseforedrag

Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2016) DNA Repair in diagnosis and therapy of cancer - opportunities and problems. 1st International NTNU Symposium on Clinical Biomarkers of Cancer
Konferanseposter

Aachmann, Finn L.; Buchinger, Edith; Slupphaug, Geir. (2016) Interaction studies of UNG2 with its DNA replication fork partners. Euromar 2016
Foredrag

Krokan, Hans Einar; Slupphaug, Geir; Sætrom, Pål; Sarno, Antonio; Galashevskaya, Anastasia; Lundbæk, Marie Benner; Aas, Per Arne; Krokan, Ruth Haaland; Liabakk, Nina-Beate; Pettersen, Henrik Sahlin. (2016) Genomic uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. Eurotox 2016

2015

Konferanseposter

Sharma, Animesh; Steven, Lewis; Dahiya, Gurvinder; Slupphaug, Geir. (2015) MS Data Analysis with a Touch of Spark. EUPA2015
Foredrag

Slupphaug, Geir. (2015) PROMEC Core Facility - Services and ongoing activities. NBS seminar
Konferanseforedrag

Slupphaug, Geir. (2015) Novel aspects of genomic uracil induction and processing. Tomas Lindahl conference on DNA repair
Konferanseposter

Buchinger, Edith; Rabe, Renana; Wiik, Siv Åshild; Slupphaug, Geir; Aachmann, Finn Lillelund. (2015) Functional impact of intrinsically disordered N-terminus on uracil-DNA glycosylase UNG2. Gordon Research Conference Computational Aspects - Biomolecular NMR

2014

Konferanseposter

Gebriel, Mohammed; Zatula, Alexey; Sousa, Mirta; Hagen, Lars; Slupphaug, Geir. (2014) From tissue to protein networks in (a bit more than) two hours: an ultrafast and a straightforward single-run LC-MS/MS approach for comprehensive proteome analyses. NBS Contact Meeting 2014
Foredrag

Slupphaug, Geir. (2014) PROMEC core facilityWhat can we offer?One example of quantitative protein profiling to identify factors underlying Melphalan resistance in multiple myeloma. Onsdagsforedrag, Institutt for Kreftforskning og Molekylærmedisin
Konferanseforedrag

Slupphaug, Geir. (2014) Novel mechanisms contributing to acquired Melphalan resistance in Multiple Myeloma. Torsdahsforedrag, KG Jebsen center for Myeloma Research
Konferanseposter

Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Abdollahi, Pegah; Vansemb, Esten; Hagen, Lars; Baranowska, Katarzyna Anna; Misund, Kristine; Slupphaug, Geir; Børset, Magne. (2014) PRL-3 Mediates Survival of Primary Myeloma Cells. American Society of Hematology Annual Meeting
Konferanseposter

Zatula, Alexey; Demirovic, Aida; Sharma, Animesh; Sousa, Mirta; Sundan, Anders; Slupphaug, Geir. (2014) Biomarker discovery and subtype classification within Multiple Myeloma by Super-SILAC. 2014 Nordic Proteomics Conference
Konferanseposter

Gebriel, Mohammed; Sousa, Mirta; Slupphaug, Geir. (2014) Global Proteomic monitoring of Phosphoproteome dynamics during rotenone-induced apoptosis in HeLa cells. NBS Contact Meeting 2014
Konferanseposter

Macur, Katarzyna; Hagen, Lars; Ciesielski, Tomasz Maciej; Konieczna, Lucyna; Skokowski, Jaroslaw; Jenssen, Bjørn Munro; Slupphaug, Geir; Baczek, Tomasz. (2014) Optimization of workflow for targeted MS-based proteomic quantification of osteopontin in healthy and cancerous human breast tissues. 20th International Mass Spectrometry Conference

2013

Konferanseforedrag

Sousa, Mirta; Slupphaug, Geir. (2013) Targeted Quantitation of Proteins by Mass Spectrometry. Monday Meeting - IKM
Konferanseforedrag

Sousa, Mirta; Slupphaug, Geir. (2013) Biomarker discovery in multiple myeloma by targeted absolute quantitative proteomics. Trent Northen Group Meeting
Konferanseposter

Macur, Katarzyna; Hagen, Lars; Ciesielski, Tomasz Maciej; Konieczna, Lucyna; Skokowski, Jaroslaw; Jensen, Bjørn Munro; Slupphaug, Geir; Baczek, Tomasz. (2013) Targeted MS-based proteomic quantitation of osteopontin in healthy and cancerous human breast tissues. 7th Polish-German Symposium on Pharmaceutical Sciences Interdisciplinary research for pharmacy

2012

Konferanseposter

Andersen, Martin Vejle; Doseth, Berit; Hem, Cecilie Anne Dahl; Brembu, Tore; Winge, Per; Slupphaug, Geir; Bones, Atle M.. (2012) Purification and characterisation of an unusual DNA glycosylase in diatoms. 3rd Erling Seeberg Symposium on DNA Repair
Konferanseposter

Andersen, Martin Vejle; Doseth, Berit; Hem, Cecilie Anne Dahl; Brembu, Tore; Winge, Per; Slupphaug, Geir; Bones, Atle M.. (2012) Purification and characterisation of an unusual DNA glycosylase in diatoms. 22nd International Diatom Symposium
Konferanseforedrag

Slupphaug, Geir. (2012) The FUGE Proteomics node, NTNU. Instituttdag, IKM
Konferanseposter

Iveland, Tobias Solli; Steen, Kristian Wollen; Hagen, Lars; Slupphaug, Geir. (2012) Ubiquitin independent proteosomal degradation of Uracil DNA Glycosylase 2. 3rd Erling Seeberg Symposium
Konferanseforedrag

Slupphaug, Geir. (2012) Proteomikk-kjernefasilitet ved NTNU/HMNHva kan vi tilby av analyser?. Fredagsforedrag S

2011

Konferanseposter

Sousa, Mirta; Zub, Kamila; Aas, Per Arne; Young, Clifford; Tian, Erming; Jensen, Ole Nørregaard; Slupphaug, Geir. (2011) Proteomics screening identifies AKR1C proteins as potential markers for resistance in melphalan resistant RPMI8226-LR5 myeloma cells. 4th EU-USA conference on DNA base damage and repair
Konferanseposter

Sousa, Mirta; Zub, Kamila; Aas, Per Arne; Tian, Erming; Liabakk, Nina-Beate; Young, Clifford; Jensen, Ole Nørregaard; Slupphaug, Geir. (2011) Switch in ATM/ATR expression and up-regulation of NHEJ proteins contribute to acquired melphalan resistance in RPMI8226 myeloma cells. 2nd nordic proteomics symposium
Konferanseposter

Baglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda; Zub, Kamila; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Cancer Proteomics 2011, European Molecular Biology Organization
Konferanseposter

Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. 4th EU-USA conference on DNA base damage and repair

2010

Konferanseforedrag

Sousa, Mirta; Steen, Kristian Wollen; Hagen, Lars; Slupphaug, Geir. (2010) Antibody crosslinking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis. 6th Norwegian National Proteomics Meeting
Konferanseforedrag

Bergstrøm, Bjarte Aune; Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit Walbye. (2010) Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3). The 6th Norwegian Proteomics Conference
Konferanseforedrag

Slupphaug, Geir. (2010) Keynote address. 6th Norwegian National Proteomics meeting
Konferanseforedrag

Slupphaug, Geir. (2010) Proteomics and Nanomedicine. nanomedicine seminar
Konferanseforedrag

Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Slupphaug, Geir. (2010) Post translational modifications of the human DNA repair protein uracil DNA glycosylase, UNG2. 6th Norwegian National Proteomics Meeting
Konferanseforedrag

Zub, Kamila; Sousa, Mirta; Aas, Per Arne; Young, Clifford; Tian, Erming; Johansen, Jostein; Hagen, Lars; Jensen, Ole Nørregaard; Slupphaug, Geir. (2010) A proteomics and genomic approach to identify factors associated with melphalan resistance in multiple myeloma cells. 6th Norwegian National Proteomics Meeting
Konferanseforedrag

Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. 6th Norwegian National Proteomics Meeting

2009

Konferanseposter

Zub, Kamila; Sousa, Mirta; Young, Clifford; Tian, Erming; Hagen, Lars; Slupphaug, Geir. (2009) Differential protein expression in melphalan sensitive and resistant multiple myeloma cells revealed by SILAC-based quantitative proteomics. 5th Norwegian National Proteomics meeting
Konferanseposter

Sousa, Mirta; Tian, Erming; Hanssen-Bauer, Audun; Zub, Kamila; Banica, Ana; Slupphaug, Geir. (2009) MBD4 is a candidate protein in development of drug resistance in multiple myeloma. The norwegian biochemical society 45th contact meeting
Konferanseforedrag

Slupphaug, Geir; Doseth, Berit; Kavli, Bodil Merete; Visnes, Torkild; Hagen, Lars; Torseth, Kathrin; Pettersen, Henrik Sahlin; Akbari, Mansour; Otterlei, Marit; Krokan, Hans Einar. (2009) Genomic uracil processing in mice and men. 2.nd Erling Seeberg symposium on DNA repair
Konferanseforedrag

Slupphaug, Geir. (2009) Nye funn innen DNA-reparasjon hos mennesker. DKNVS foredrag
Konferanseforedrag

Slupphaug, Geir. (2009) Regulation of Genomic Uracil Processing in Mammalian Cells. 3rd US-EU Conference on Repair of Endogenous Genome Damage, Galveston, Texas
Konferanseforedrag

Slupphaug, Geir. (2009) Proteomic Tools in the discovery of Biomarkers. Lily Seminar "An introduction to Cancer Biomarkers in NSCLC"
Konferanseforedrag

Bergstrøm, Bjarte; Nguyen, Thuy Tranh; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit W.. (2009) Exploring phosphorylation of the transcription factor Interferon Regulatory Factor 3 in vivo and in vitro. Contact Meeting NBS
Konferanseforedrag

Slupphaug, Geir. (2009) Regulation of genomic uracil processing in mammalian cells, multiple levels of control of UNG2. Tuesday Lecture, IKM
Konferanseforedrag

Krokan, Hans Einar; Visnes, Torkild; Doseth, Berit; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir. (2009) Uracil in DNA and its processing. 3rd US-EU Conference- Repair of Endogenous Genome Damage
Konferanseforedrag

Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka; Catterall, Tara C; Vågbø, Cathrine Broberg; Liabakk, Nina-Beate; Slupphaug, Geir. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. 2nd Erling Seeberg Symposium on DNA Repair
Konferanseforedrag

Slupphaug, Geir. (2009) Regulation of genomic uracil processing by UNG2. Guest Lecture, Ludwig-Maximillians University, Munich
Konferanseforedrag

Bergstrøm, Bjarte; Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit Walbye. (2009) Exploring phosphorylation of the transcription factor Interferon Regulatory Factor 3 in vivo and in vitro. NBS kontaktmøte 2009
Foredrag

Slupphaug, Geir. (2009) Molecular mechanisms of host defence. Presentation for the Chinese Embassy
Konferanseposter

Zub, Kamila; Sousa, Mirta; Young, Clifford; Tian, Erming; Johansen, Jostein; Hagen, Lars; Jensen, Ole Nørregaard; Slupphaug, Geir. (2009) What a difference melphalan makes! Differential protein expression in melphalan resistant and sensitive multiple myeloma cells using SILAC analysis. Proteomics Europe

2008

Konferanseforedrag

Slupphaug, Geir. (2008) Post-translational modifications regulating DNA repair. Trondheim Conference on Systems Biology
Konferanseforedrag

Slupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance
Konferanseforedrag

Slupphaug, Geir. (2008) The never-ending story of UNG. Mandagsforedrag Faggr. for molekylærbiologi IKM
Konferanseforedrag

Slupphaug, Geir. (2008) Proteomic studies in DNA repair. Seminar, Institutt for Bioteknologi, NTNU
Konferanseforedrag

Slupphaug, Geir. (2008) Regulation of uracil-DNA repair by post-translational modification of UNG2. BBB Seminar series, University of Bergen
Konferanseforedrag

Slupphaug, Geir. (2008) The Interactomics of DNA repair. Oppdalsmøte, FUGE Midt-Norge og NBS Trøndelag

2007

Foredrag

Slupphaug, Geir. (2007) Administrative støtteprosesser ved DMF - innspill fra vitenskapelige ansatte. Allmøte, DMF
Konferanseforedrag

Slupphaug, Geir. (2007) RNA damage and repair and medical significance. 37th annual meeting of the European environmental society, EEMS
Konferanseforedrag

Slupphaug, Geir. (2007) Cell cycle regulation of Uracil repair. Tirsdagsforedrag, Institutt for kreftforskning og molekylærmedisin
Konferanseforedrag

Slupphaug, Geir. (2007) Cell Cycle Regulated Phosphorylations of Human Uracil-DNA Glycosylase UNG2 Govern Replication-Associated Uracil Removal. Mandagsforedrag, Institutt for kreftforskning og molekylærmedisin
Konferanseforedrag

Slupphaug, Geir. (2007) Proteomics. Instituttdag, Institutt for Kreftforskning og Molekylærmedisin, DMF

2006

Konferanseforedrag

Slupphaug, Geir. (2006) Phosphorylation of UNG2 and potential functional implications. Tirsdagsforedrag
Konferanseforedrag

Slupphaug, Geir. (2006) Forskningsaktiviteter ved IKM, Laboratoriesenteret. Instituttsamling, Inst. for Laboratoriemedisin, NTNU
Konferanseforedrag

Slupphaug, Geir. (2006) DNA repair and acquired immunity. Invitert foredrag
Konferanseforedrag

Slupphaug, Geir. (2006) Human UNG2 - a uracil DNA glycosylase of many functions. Invitert foredrag, Departement de Maladies Infectieuses, Institut Cochin
Konferanseforedrag

Slupphaug, Geir. (2006) The Proteomics Laboratory at IKM, NTNU. FUGE-seminar
Konferanseforedrag

Slupphaug, Geir. (2006) Regulation of Uracil Base Excision Repair by Post-translational modifications. Erling Seeberg Symposium on DNA Repair
Konferanseposter

Sousa, Mirta; Sundheim, Ottar; Vågbø, Cathrine Broberg; Talstad, Vivi; Aslaksen, Petter Broby; Slupphaug, Geir. (2006) Post-translational self-hydroxilation of an active site leucine in human ABH3 may protect against generation of damaging oxygen radicals. Erling Seeberg Symposium on DNA Repair
Konferanseposter

Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Erling Seeberg Symposium on DNA Repair
Konferanseposter

Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A; Slupphaug, Geir. (2006) Crystal structure of hABH3 DNA/RNA demethylase reveals a novel active-site leucine oxidation. The Norwegian Biochemical Society 42. Contact Meeting
Konferanseposter

Hagen, Lars; Kavli, Bodil Merete; Sundheim, Ottar; Sousa, Mirta; Otterlei, Marit; Liabakk, Nina-Beate; Torseth, Kathrin; Krokan, Hans Einar; Slupphaug, Geir. (2006) Regulation of uracil base excision repair by post-translational modifications. Erling Seeberg Symposium on DNA Repair

2005

Konferanseposter

Kavli, Bodil Merete; Diaz, Javier Pena; Otterlei, Marit; Liabakk, Nina-Beate; Giljam, Karin Margaretha; Krokan, Hans Einar; Hørning, Ole; Jensen, Ole N; Slupphaug, Geir; Hagen, Lars. (2005) The enzymatic activity of human uracil-DNA glycosylase UNG2 is regulated by N-terminal phosphorylation during cell cycle. 2nd EU-US DNA Repair Meeting: Endogeneous Stress, Base excision repair and related processes
Konferanseforedrag

Slupphaug, Geir. (2005) Structure of the hABH3 DNA demethylase implicates an oxidized leucine residue in catalysis. 2nd ESF Functional Genomics conference. Satellite meeting - Functional genomics in the Nordic countries
Konferanseforedrag

Slupphaug, Geir. (2005) Proteomics and the molecular choreography of mammalian DNA base excision repair. 1st National proteomics meeting
Konferanseforedrag

Slupphaug, Geir. (2005) Post-translational modifications of hABH3 and UNG2 and their biological implications. 2nd EU-US DNA Repair Meeting. Endogeneous stress, base excision repair and related processes
Konferanseposter

Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A; Slupphaug, Geir. (2005) Structure of the hABH3 DNA demethylase implicates an oxidized leucine residue in catalysis. 2nd ESF Functional Genomics and disease
Konferanseposter

Diaz, Javier Pena; Hegre, Siv Anita; Akbari, Mansour; Sousa, Mirta; Sundheim, Ottar; Hanssen-Bauer, Audun; Slupphaug, Geir; Krokan, Hans Einar; Otterlei, Marit. (2005) Recruitment of the chaperone Hsp70 to Base Excision Repair complexes. 2nd EU-US DNA RepairMeeting
Konferanseposter

Nguyen, Thank Thuy Thi; Johnsen, Ingvild Bjellmo; Hagen, Lars; Torseth, Kathrin; Espevik, Terje; Slupphaug, Geir; Anthonsen, Marit Walbye. (2005) Identification of novel proteins associated with a pathogen patten recognition receptor mediating antiviral immune responses. The Norwegian Biochemical Society 41st Contact Meeting

2004

Konferanseforedrag

Slupphaug, Geir. (2004) Proteomics and the molecular coordination of DNA uracil base excision repair. The 5th Proteome Information Exchange meeting
Intervju

Slupphaug, Geir. (2004) Gen-skrotet som ble til gull.
Konferanseposter

Sundheim, Ottar; Krokan, Hans Einar; Slupphaug, Geir. (2004) Structural anc biochemical analysis of the major groove recognition loop (MGRL). Gordon Conference on Mutagenesis
Konferanseposter

Kavli, Bodil; Otterlei, Marit; Liabakk, Nina-Beate; Krokan, Hans Einar; Slupphaug, Geir. (2004) The mutant UNG2-F-25 1S associated with HIGM syndrome is abnormally translocated and degraded, and results in impaired nuclear uracil excision and accumulation of genomic uracil. ASM Conference on DNA Repair and Mutagenesis
Intervju

Slupphaug, Geir. (2004) Bare late B-mennesker.
Konferanseposter

Sundheim, Ottar; Parikh, Sudip S; Lund, Terje; Krokan, Hans Einar; Slupphaug, Geir; Tainer, John A. (2004) Structural and biochemical analysis of the minor-groove recognition loop (MGRL) motif in UDG. DNA repair and mutagenesis: From molecular structure to biological consequences

2002

Foredrag

Slupphaug, Geir. (2002) Dypdykk i DNA-molekylet - Hva er nå det for slags liv?. [Mangler data]
Konferanseposter

Kavli, Bodil; Otterlei, Marit; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in uracil-DNA repair in the nucleus. Mutagenesis and Carcinogenesis, Gordon Research Conference
Konferanseposter

Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2002) Substrate preference and enzyme kinetics reveal distinct properties of UNG2 and SMUG1 in cellular base-excision repair; hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup. 32nd Annual Meeting of European Environmental Mutagen Society. DNA Damage and Repair Fundamental Aspects and Contribution to Human Disorders
Konferanseposter

Andersen, Sonja; Nilsen, Hilde; Grøsvik, K; Kønig, I; Sneve, R; Slupphaug, Geir; Stamp, G; Hrivnak, G; Lindahl, T; Barnes, D.E. (2002) "URACIL-DNAGLYCOSYLASE KNOCKOUT MICE-effects on lifespan and health. Characterisation of uracil removing activities in wild type and Ung deficient mice.". Meeting on DNA repair
Konferanseposter

Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Otterlei, Marit; Skorpen, Frank; Krokan, Hans Einar; Slupphaug, Geir. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in DNA-uracil repair in the nucleus. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life
Konferanseposter

Andersen, Sonja; Nilsen, Hilde; Grøsvik, K; Kønig, I; Sneve, R; Slupphaug, Geir; Krokan, Hans Einar. (2002) Uracil-DNA glycosylase knockout mice. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life
Konferanseposter

Pena-Diaz, Javier; Farez-Vidal, M.E; Sundheim, Ottar; Leal-Cortijo, I; Gonzales-Pacanowska, D; Krokan, Hans Einar; Slupphaug, Geir. (2002) Kinetic characterisation of the uracil-DNA glycosylase from the protozoa parasite Trypanosome cruziNorsk biokjemis. 38. Biokjemiske kontaktmøte
Konferanseforedrag

Aas, Per Arne; Otterlei, Marit; Skorpen, Frank; Akbari, Mansour; Slupphaug, Geir; Krokan, Hans Einar. (2002) Repair of alkylated single-stranded DNA and RNA in living cells. 38.Biokjemiske kontaktmøte Functional genomics-the mosaics of life

2001

Foredrag

Slupphaug, Geir. (2001) Regulering av base-eksisjonsreparasjon. [Mangler data]
Foredrag

Slupphaug, Geir. (2001) Functions of different UDGS in mammalian cells. [Mangler data]
Konferanseforedrag

Slupphaug, Geir. (2001) Functional implications of the UNG2 regulatory domain in BER and transcription regulation. Workshop DNA repair.
Konferanseforedrag

Slupphaug, Geir. (2001) Functional Genomics and the future. Section for medical Genetics.
Konferanseposter

Sundheim, Ottar; Otterlei, Marit; Kavli, Bodil; Skorpen, Frank; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2001) Structure-function analysis of the human uracil-DNA glycosylase hSMUG1. Sixth International School on the Crystallography of Biological Macromolecules.
Deltakelse i radio- eller TV

Slupphaug, Geir. (2001) Litt mer avansert enn bananflua.
Konferanseposter

Slupphaug, Geir; Skorpen, Frank; Nilsen, H.; Fenstad, M.; Rosello, Ch.; Otterlei, Marit; Aas, P.A.; Krokan, Hans Einar. (2001) Functional implications of the UNG2 regulatory domain in BER and transcription regulation. Workshop DNA repair: Interplay with other cellular processes
Konferanseforedrag

Imsland, Lars Struen; Slupphaug, Geir; Foss, Bjarne Anton. (2001) Robust observer-based output feedback for nonlinear discrete-time systems with constraints. NOLCOS 2001
Konferanseforedrag

Imsland, Lars Struen; Slupphaug, Geir; Foss, Bjarne Anton. (2001) Piecewise affine observer-based robust controllers for constrained nonlinear systems. European Control Conference 2001

2000

Konferanseforedrag

Johansen, Tor Arne; Petersen, Idar; Slupphaug, Geir. (2000) On explicit suboptimal LQR with state and input constraints. IEEE Conference on Decision and Control
Konferanseforedrag

Johansen, Tor Arne; Petersen, Idar; Slupphaug, Geir. (2000) Explicit suboptimal constrained LQR. Workshop on systems with time-domain constraints
Konferanseforedrag

Slupphaug, Geir; Foss, Bjarne Anton. (2000) Multi-model based uncertainty and robust control design. IFAC Symposium ADCHEM
Konferanseforedrag

Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne; Foss, Bjarne Anton. (2000) Stabilizing linear MPC with efficient prioritized infeasibility handling. IFAC Symposium ADCHEM
Deltakelse i radio- eller TV

Slupphaug, Geir. (2000) Schrødingers katt - Månebarna.
Foredrag

Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Slupphaug, Geir; Barnes, Deborah; Lindahl, Tomas. (2000) Structure-function aspects of human uracil-DNA glycosylase and its interactions with other proteins. DNA Base Excision Repair Workshop (BER 2000 WORKSHOP)
Foredrag

Nilsen, Hilde; Roswell, Ian; Robins, Peter; Slupphaug, Geir; Steinsbekk, Kristin; Otterlei, Marit; Andersen, Sonja; Lindahl, Tomas; Barnes, Deborah; Krokan, Hans Einar. (2000) Characterisation Of The Major Murine Uracil-DNA Glycosylase And Expression Patterns And Generation of ung/-Knockout Mice. DNA Base Excision Repair Workshop (BER 2000 Workshop)
Foredrag

Parikh, Sudip S; Walcher, Gunter; Jones, Garry D; Slupphaug, Geir; Krokan, Hans Einar; Tainer, John A. (2000) UDG-DNA Uncleaved-Substrate Structure is Strained by Coupled Stereoelectronic Effects. DNA Base Excision Repair Workshop (BER 2000 Workshop)
Konferanseforedrag

Slupphaug, Geir. (2000) Frequency Domain Curve Fitting: A Global Approach. IEEE Conference on Decision and Control

1999

Konferanseposter

Krokan, Hans Einar; Slupphaug, Geir; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank. (1999) Excicion Repar of DNA Damage 1. [Mangler data]
Konferanseposter

Barikh, S.S.; Lund, T.; Slupphaug, Geir; Krokan, Hans Einar; Ghazal, P.; Tainer, J.A.. (1999) Structural and biochemical analysis of a cytomegalovirus-human UDG chimera created by functional segment exchange. [Mangler data]
Konferanseforedrag

Vada, Jostein; Slupphaug, Geir; Foss, Bjarne Anton. (1999) Infeasibility handling in linear MPC subject to prioritized constraints. Preprints of the 14th World Congress of IFAC
Konferanseforedrag

Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (1999) Efficient infeasibility handling in linear MPC subject to prioritized constraints. Proceedings of European Control Conference '99

1998

Foredrag

Slupphaug, Geir. (1998) Søkelys på gentekologi. Rotary
Foredrag

Slupphaug, Geir. (1998) Søkelys på genteknologi. Rotary
Foredrag

Slupphaug, Geir. (1998) På kryss og tvers med proteiner. Innledningsforedrag, etterutdanningskurs for bioingeniører
Konferanseforedrag

Bharati, Sangeeta; Krokan, Hans Einar; Kristiansen, Lena; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1)is processed to two forms one of which is resistant to inhibition by AP-sites. AACR Special Conference in Cancer Research. Endogeneous sources of Mutations.
Konferanseforedrag

Slupphaug, Geir; Foss, Bjarne Anton. (1998) Robust stabilization of discrete-time multi-model systems using piecewise affine state-feedback. Dynamics and Control for Process Systems
Konferanseforedrag

Slupphaug, Geir; Foss, Bjarne Anton. (1998) Bilinear matrix inequalities and robust stability of nonlinear multi-model MPC. American Control Conference

1997

Konferanseforedrag

Slupphaug, Geir; Foss, Bjarne Anton. (1997) Model predictive control for a class of hybrid systems. European Control Conference
Konferanseforedrag

Slupphaug, Geir; Vada, Jostein; Foss, Bjarne Anton. (1997) MPC in systems with continuous and discrete control inputs. American Control Conference

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Geir Slupphaug

Geir Slupphaug

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Proteomics, Genome Dynamics and DNA repair

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