Geir Slupphaug

Om

Proteomics, Genome Dynamics and DNA repair

I entered the field of mammalian DNA repair in the late 1980ies, moving from plant molecular biology. I then joined the group of Professor Hans E. Krokan, and started working on molecular mechanisms underlying repair of base lesions in DNA. A primary focus of the research was to understand how the erroneous DNA base uracil was removed from DNA. Uracil is a mutagenic DNA lesion occurring several hundred times per day in each cell. It is primarily removed by the enzyme uracil-DNA glycosylase (UNG), that initiates a multistep enzymatic pathway to restore the original DNA sequence. Thanks to the recent cloning of the human UNG gene we were able produce sufficient amounts of recombinant enzyme for functional and 3D-structure analysis. This laid the basis for several fundamental discoveries concerning the functioning of DNA glycosylases, including the concept of DNA base flipping in DNA repair. Much of this research was conducted in collaboration with Prof. John A. Tainer at the Scripps Research Institute in San Diego. I was also fortunate to spend a year in his lab as a guest researcher in the mid-90ies.

Cocrystal structure of UNG and uracil-containing DNA

Through the years it became clear that the nuclear isoform of UNG, UNG2 is a truly multifunctional enzyme. Moreover, we now know that uracil is not a mere lesion in DNA, but can be enzymatically introduced into specific genes. In activated B-cells, the enzyme AID deaminates cytosine to uracil in the immunoglobulin genes. These uracils are also removed by UNG2. Paradoxically, however, the resulting baseless (AP) site is not repaired, but rather funneled through a mutagenic pathway that enhances the affinity as well as the effector functions of the final antibodies. Thus, both AID and UNG2 are crucial for the normal immune response, and lack of UNG2 results in hyper-IgM syndrome in humans. Moreover, mutagenic processing of genomic uracil encompasses several enzymes that normally act in DNA repair pathways, demonstrating the interplay between different cellular functions by employing common factors for different purposes. This, however, does not come without a cost. Recent large-scale sequencing of human cancers indicates that off-targeted enzymatic deamination of cytosine by the AID/APOBEC family of cytidine deaminases may be involved in the development of a large fraction of human cancers, including B-cell lymphomas. We have also observed a marked increase in B-cell lymphomas in Ung-deficient mice.

Model of B-cell lymphoma development in Ung-deficient mice

Finally, UNG2 is also important in the defense against retrovirus, e.g. HIV-1. High concentrations of dUTP in the target cells promote misincorporation of uracil in the viral DNA and host cell APOBEC proteins may promote deamination of cytosine in the viral DNA. This facilitates degradation of viral DNA by UNG2 and AP-endonuclease. In conclusion, uracil in DNA is both a mutagenic burden and a tool to modify DNA for diversity or degradation.

Employing a cellular protein for different functions can be regulated at several levels, e.g. by directing the protein to various subcellular compartments, adjusting its level through the cell cycle, or by introducing specific post-translational modifications to the protein to alter its interaction with other cellular components to e.g. form novel protein complexes. To study such phenomena in more detail we acquired our first mass spectrometry instrument for proteomic analyses in the early 2000nds. This activity has steadily grown and has allowed us to decipher novel regulatory mechanisms both within DNA repair, but also in other biochemical processes linked to human disease. We have also established analytical pipelines for quantitative determination of >50 modified bases in DNA and RNA. This has allowed us to perform parallel monitoring of DNA/RNA modifications and protein profiling in various diseased tissues to aid e.g. biomarker discovery. A present focus of our studies is to map potential functions of DNA modifications previously considered mere lesions, in the fine-tuning of gene-expression and epigenetic reprogramming.

In 2013 the mass spectrometry laboratory at IKM was appointed a core facility for proteomics and metabolomics (PROMEC) at NTNU, and we currently perform analytical service for several research groups both within and outside NTNU.

Davi at the Orbitrap Elite

Current research group (including core facility personnel)

Publikasjoner

2022

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2022) MS-proteomics provides insight into the host responses towards alginate microspheres. Materials Today Bio. volum 17.
Vitenskapelig artikkel

2021

Alswady-Hoff, Mayes; Erdem, Johanna Maria Samulin; Phuyal, Santosh; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Skare, Øivind; Slupphaug, Geir; Zienolddiny, Shanbeh. (2021) Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells. International Journal of Molecular Sciences. volum 22 (10).
Vitenskapelig artikkel
Alves, Christiano R. R.; Eichelberger, Eric J.; das Neves, Willian; Ribeiro, Márcio A. C.; Bechara, Luiz R.G.; Voltarelli, Vanessa A.; de Almeida, Ney R.; Hagen, Lars; Sharma, Animesh; Ferreira, Julio C. B.; Swoboda, Kathryn J.; Slupphaug, Geir; Brum, Patricia C.. (2021) Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity. The FASEB Journal. volum 35 (7).
Vitenskapelig artikkel
Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Fernandez Berrocal, Marion Silvana; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna; Olsen, Ann-Karin Hardie; Gutzkow, Kristine Bjerve; Rowe, Alexander D.; Wang, Wei; Moldestad, Olve; Syrstad, Monica Dahl; Slupphaug, Geir; Eide, Lars; Klungland, Arne; Sætrom, Pål; Luna, Luisa; Ye, Jing; Scheffler, Katja; Bjørås, Magnar. (2021) NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. Communications Biology. volum 4.
Vitenskapelig artikkel
Iveland, Tobias S.; Hagen, Lars; Sharma, Animesh; Sousa, Mirta M. L.; Sarno, Antonio; Wollen, Kristian Lied; Liabakk, Nina-Beate; Slupphaug, Geir. (2021) Correction to: HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines (Journal of Translational Medicine, (2020), 18, 1, (159), 10.1186/s12967-020-02318-8). Journal of Translational Medicine. volum 19 (1).
Errata
Kavli, Bodil Merete; Iveland, Tobias Solli; Buchinger, Edith; Hagen, Lars; Liabakk, Nina-Beate; Aas, Per Arne; Obermann, Tobias Sebastian; Aachmann, Finn Lillelund; Slupphaug, Geir. (2021) RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork. Nucleic Acids Research (NAR). volum 49 (7).
Vitenskapelig artikkel
Olinski, Ryszard; Slupphaug, Geir; Foksinski, Marek; Krokan, Hans Einar. (2021) Genomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignancies. International Journal of Molecular Sciences. volum 22 (8).
Vitenskapelig artikkel
Steen, Kristian Wollen; Hagen, Lars; Vågbø, Cathrine Broberg; Rabe, Renana; Iveland, Tobias Solli; Aas, Per Arne; Sharma, Animesh; Sporsheim, Bjørnar; Erlandsen, Hilde; Palibrk, Vuk; Bjørås, Magnar; Fonseca, Davi de Miranda; Mosammaparast, Nima; Slupphaug, Geir. (2021) ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA. Journal of Translational Medicine. volum 19 (1).
Vitenskapelig artikkel
Wang, Qiong; Karvelsson, Sigurdur Trausti; Johannsson, Freyr; Vilhjalmsson, Arnar Ingi; Hagen, Lars; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Rolfsson, Ottar. (2021) UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines. Molecular Oncology.
Vitenskapelig artikkel

2020

Alves, Christiano R. R.; des Neves, Willian; de Almeida, Ney R; Eichelberger, Eric J; Jannig, Paulo R.; Voltarelli, Vanessa A; Tobias, Gabriel C; Bechara, Luiz R G; de Paula Faria, Daniele; Alves, Maria J N; Hagen, Lars; Sharma, Animesh; Slupphaug, Geir; Moreira, Jose Bianco Nascimento; Wisløff, Ulrik; Hirshman, Michael F.; Negrao, Carlos E.; de Castro Jr, Gilberto; Chammas, Roger; Swoboda, Kathryn J.; Ruas, Jorge L.; Goodyear, Laurie J.; Brum, Patricia Chakur. (2020) Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN. Molecular Metabolism.
Vitenskapelig artikkel
Eldin, Patrick; Péron, Sophie; Galashevskaya, Anastasia; Denis-Lagache, Nicolas; Cogné, Michel; Slupphaug, Geir; Briant, Laurence. (2020) Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination. Journal of Translational Medicine. volum 18 (1).
Vitenskapelig artikkel
Iveland, Tobias Solli; Hagen, Lars; Sharma, Animesh; Sousa, Mirta; Sarno, Antonio; Wollen, Kristian Lied; Liabakk, Nina-Beate; Slupphaug, Geir. (2020) HDACi Mediate UNG2 Depletion, Dysregulated Genomic Uracil and Altered Expression of Oncoproteins and Tumor Suppressors in B- And T-cell Lines. Journal of Translational Medicine. volum 18.
Vitenskapelig artikkel
Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2020) Genomic Uracil in Biology, Immunity and Cancer. DNA Damage, DNA Repair and Disease: Volume 1.
Vitenskapelig kapittel/artikkel
Vågbø, Cathrine Broberg; Slupphaug, Geir. (2020) RNA in DNA repair. DNA Repair. volum 95.
Vitenskapelig artikkel
Yang, Rui; Elsaadi, Samah; Misund, Kristine; Abdollahi, Pegah; Vandsemb, Esten; Moen, Siv Helen; Kusnierczyk, Anna; Slupphaug, Geir; Standal, Therese; Waage, Anders; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Rustad, Even Holth; Sundan, Anders; Hay, Carl; Cooper, Zachary; Schuller, Alwin G.; Woessner, Richard; Borodowski, Alexandra; Menu, Eline; Børset, Magne; Sponaas, Anne-Marit. (2020) Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade. Journal for ImmunoTherapy of Cancer (JITC).
Vitenskapelig artikkel

2019

Macur, Katarzyna; Hagen, Lars; Ciesielski, Tomasz Maciej; Konieczna, Lucyna; Skokowski, Jaroslaw; Jenssen, Bjørn Munro; Slupphaug, Geir; Baczek, Tomasz. (2019) A targeted mass spectrometry immunoassay to quantify osteopontin in fresh-frozen breast tumors and adjacent normal breast tissues. Journal of Proteomics. volum 208.
Vitenskapelig artikkel
Pinto, Rita; Vågbø, Cathrine Broberg; Jakobsson, Magnus; Yeji, Kim; Baltissen, Marijke P; O'Donohue, Marie-Francoise; Guzman, Ulises H; Malecki, Jedrzej Mieczyslaw; Wu, Jie; Kirpekar, Finn; Olsen, Jesper V; Gleizes, Pierre-Emmanuel; Vermeulen, Michiel; Leidel, Sebastian A.; Slupphaug, Geir; Falnes, Pål Øystein. (2019) The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Nucleic Acids Research (NAR). volum 48 (2).
Vitenskapelig artikkel
Steinacher, Roland; Barekati, Zeinab; Botev, Petar; Kusnierczyk, Anna; Slupphaug, Geir; Schär, Primo. (2019) SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation. EMBO Journal. volum 38 (1).
Vitenskapelig artikkel

2018

Kavli, Bodil Merete; Slupphaug, Geir. (2018) Genomic Uracil and Immunity. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Sarno, Antonio; Slupphaug, Geir. (2018) Enzymology of Genomic Uracil Repair. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) DNA Repair is Integrated with Many Cellular Processes. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) Viral Uracil - Uracil DNA glycosylases and dUTPases. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir; Drabløs, Finn. (2018) The Earth, Life and Genomic Uracil. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Phuyal, Santosh; Kasem, Mayes; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Vebraite, Vaineta; Shaposhnikov, Sergey; Slupphaug, Geir; Skaug, Vidar; Zienolddiny, Shanbeh. (2018) Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes. Nanotoxicology. volum 12 (2).
Vitenskapelig artikkel
Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2018) Routes to Uracil in DNA. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil - Evolution, Biology, Immunology and Disease. World Scientific. 2018. ISBN 978-981-3233-49-2.
Fagbok
Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil – Valuable Tool in Molecular Biology but Inherent Problem in Sequencing of Ancient DNA. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Alves, Marcia Netto Magalhaes; Wohlwend, Martin; Gebriel, Mohammed; Hagen, Lars; Sharma, Animesh; Koch, Lauren G.; Britton, Steven L.; Slupphaug, Geir; Wisløff, Ulrik; Brum, Patricia C.. (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Scientific Reports. volum 8 (1).
Vitenskapelig artikkel
Zhao, Chun-Mei; Rabben, Hanne-Line; Zhu, Yanping; Olsen, Magnus Kringstad; Wang, Zhiqiang; Hao, Yanpeng; Cai, Xing; Fonseca, Davi de Miranda; Sharma, Animesh; Li, Mingna; Zhihong, Zhang; Slupphaug, Geir; Wang, Timothy Cragin; Chen, Duan. (2018) 390 - A New Treatment for Pancreatic Cancer: Targeting Nervecancer Cell Crosstalk. Gastroenterology. volum 154.
Sammendrag/abstract

2017

Brickner, Joshua R; Soll, Jennifer M; Lombardi, Patrick M; Vågbø, Cathrine Broberg; Mudge, Miranda C; Oyeniran, Clement; Rabe, Renana; Jackson, Jessica; Sullender, Meagan E; Blazosky, Elyse; Byrum, Andrea K; Zhao, Yu; Corbett, Mark A.; Gècz, Jozef; Field, Michael; Vindigni, Alessandro; Slupphaug, Geir; Wolberger, Cynthia; Mosammaparast, Nima. (2017) A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. volum 551 (7680).
Vitenskapelig artikkel
Buchinger, Edith; Wiik, Siv Åshild; Kusnierczyk, Anna; Rabe, Renana; Aas, Per Arne; Kavli, Bodil Merete; Slupphaug, Geir; Aachmann, Finn Lillelund. (2017) Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2. Biomolecular NMR Assignments. volum 12 (1).
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir; Kavli, Bodil Merete. (2017) Genomic Uracil-Dangers and Benefits in processing. The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design.
Vitenskapelig kapittel/artikkel
Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar; Finsen, Alexandra. (2017) NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports. volum 18.
Vitenskapelig artikkel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel. Data in Brief. volum 12.
Vitenskapelig artikkel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay. Analytical Biochemistry. volum 523.
Vitenskapelig artikkel
Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja; Neurauter, Christine Gran; Esbensen, Qin Ying; Kusnierczyk, Anna; Hildrestrand, Gunn Annette; Graupner, Anne; Andersen, Jill Mari; Slupphaug, Geir; Klungland, Arne; Nilsen, Hilde; Bjørås, Magnar. (2017) No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Scientific Reports. volum 7.
Vitenskapelig artikkel
Rydning, Siri Lynne; Backe, Paul Hoff; Sousa, Mirta; Iqbal, Zafar; Øye, Ane-Marte; Sheng, Ying; Yang, Mingyi; Lin, Xiaolin; Slupphaug, Geir; Nordenmark, Tonje Haug; Vigeland, Magnus Dehli; Bjørås, Magnar; Tallaksen, Chantal; Selmer, Kaja Kristine. (2017) Corrigendum: Novel UCHL1 mutations reveal new insights into ubiquitin processing. Human Molecular Genetics. volum 26 (6).
Errata
Rydning, Siri Lynne; Backe, Paul Hoff; Sousa, Mirta; Iqbal, Zafar; Øye, Ane-Marte; Sheng, Ying; Yang, Mingyi; Lin, Xiaolin; Slupphaug, Geir; Nordenmark, Tonje Haug; Vigeland, Magnus Dehli; Bjørås, Magnar; Tallaksen, Chantal; Selmer, Kaja Kristine. (2017) Novel UCHL1 mutations reveal new insights into ubiquitin processing. Human Molecular Genetics. volum 26 (6).
Vitenskapelig artikkel
Zatula, Alexey; Dikic, Aida; Mulder, Teska Celine; Sharma, Animesh; Vågbø, Cathrine Broberg; Sousa, Mirta; Waage, Anders; Slupphaug, Geir. (2017) Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia. OncoTarget. volum 8 (12).
Vitenskapelig artikkel

2016

Helander, Linda; Sharma, Animesh; Krokan, Hans Einar; Plaetzer, Kristjan; Krammer, Barbara; Tortik, Nicole; Gederaas, Odrun Arna; Slupphaug, Geir; Hagen, Lars. (2016) Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins. Molecular Biosystems.
Vitenskapelig artikkel
Iversen, Ole-Jan; Lysvand, Hilde; Slupphaug, Geir. (2016) Pso p27, a SERPINB3/B4-derived protein, is most likely a common autoantigen in chronic inflammatory diseases. Clinical Immunology. volum 174.
Vitenskapelig artikkel
Skarpengland, Tonje; Dahl, Tuva Børresdatter; Skjelland, Mona; Scheffler, Katja; Sousa, Mirta; Gregersen, Ida; Kusnierczyk, Anna; Sharma, Animesh; Slupphaug, Geir; Eide, Lars; Segers, Filip; Skagen, Karolina Ryeng; Dahl, Christen Peder; Russell, David; Folkersen, Lasse; Krohg-Sørensen, Kirsten; Holm, Sverre; Bjørås, Magnar; Aukrust, Pål; Halvorsen, Bente. (2016) Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA. Free Radical Biology & Medicine. volum 97.
Vitenskapelig artikkel
Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna; Ketelhuth, Daniel F.J.; Lundberg, Anna M.; Neurauter, Christine Gran; Hildrestrand, Gunn Annette; Skjelland, Mona; Bjørndal, Bodil; Svardal, Asbjørn M.; Iversen, Per Ole; Hedin, Ulf; Nygård, Ståle; Olstad, Ole Kristoffer; Krohg-Sørensen, Kirsten; Slupphaug, Geir; Eide, Lars; Kusnierczyk, Anna; Folkersen, Lasse; Ueland, Thor; Berge, Rolf Kristian; Hansson, Göran K.; Biessen, Erik A.L.; Halvorsen, Bente; Bjørås, Magnar; Aukrust, Pål. (2016) Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice. Scientific Reports. volum 6:28337.
Vitenskapelig artikkel
Slupphaug, Geir. (2016) Modulering av cellulær metabolisme bidrar til Melfalan-resistens i myelomaotse. Best Practice Onkologi/Hematologi. volum 24.
Faglig artikkel

2015

Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne; Bjørås, Magnar. (2015) Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports. volum 13 (12).
Vitenskapelig artikkel
Kataya, Amr Ramzy Abass; Heidari Ahootapeh, Behzad; Hagen, Lars; Kommedal, Roald; Slupphaug, Geir; Lillo, Cathrine. (2015) Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Plant Physiology. volum 167 (2).
Vitenskapelig artikkel
Kataya, Amr Ramzy Abass; Heidari, Behzad; Hagen, Lars; Kommedal, Roald; Slupphaug, Geir; Lillo, Cathrine. (2015) Supplemental materials for: Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Plant Physiology. volum 167 (2).
Vitenskapelig artikkel
Lysvand, Hilde; Helland, Ronny; Hagen, Lars; Slupphaug, Geir; Iversen, Ole-Jan. (2015) Psoriasis pathogenesis – Pso p27 constitutes a compact structure forming large aggregates. Biochemistry and Biophysics Reports. volum 2.
Vitenskapelig artikkel
Mjelle, Robin; Hegre, Siv Anita; Aas, Per Arne; Slupphaug, Geir; Drabløs, Finn; Sætrom, Pål; Krokan, Hans Einar. (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair. volum 30.
Vitenskapelig artikkel
Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål; Kavli, Bodil Merete; Krokan, Hans Einar. (2015) AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA Repair. volum 25.
Vitenskapelig artikkel
Rolim, Natale Pinheiro Lage; Skårdal, Kristine; Høydal, Morten; Sousa, Mirta; Malmo, Vegard; Skrove, Guri Kaurstad; Ingul, Charlotte Bjørk; Hansen, Harald Edvard Mølmen; Alves, Marcia Netto Magalhaes; Thuen, Marte; Haraldseth, Olav; Brum, Patricia Chakur; Slupphaug, Geir; Loennechen, Jan Pål; Stølen, Tomas; Wisløff, Ulrik. (2015) Aerobic interval training reduces inducible ventricular arrhytmias in diabetic mice after myocardial infarction. Basic Research in Cardiology. volum 110 (44).
Vitenskapelig artikkel
Zub, Kamila; Sousa, Mirta; Sarno, Antonio; Sharma, Animesh; Dikic, Aida; Rao, Shalini; Young, Clifford; Aas, Per Arne; Ericsson, Ida; Sundan, Anders; Jensen, Ole Nørregaard; Slupphaug, Geir. (2015) Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired Melphalan resistance in multiple myeloma cells. PLOS ONE. volum 10 (3).
Vitenskapelig artikkel

2014

Hagen, Lars; Sharma, Animesh; Aas, Per Arne; Slupphaug, Geir. (2014) Off-target responses in the HeLa proteome subsequent to transient plasmid-mediated transfection. Biochimica et Biophysica Acta - Proteins and Proteomics. volum 1854 (1).
Vitenskapelig artikkel
Krokan, Hans Einar; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Kavli, Bodil Merete; Slupphaug, Geir. (2014) Error-free versus mutagenic processing of genomic uracil-Relevance to cancer. DNA Repair. volum 19.
Vitenskapelig artikkel
Lysvand, Hilde; Hagen, Lars; Klubicka, Lidija; Slupphaug, Geir; Iversen, Ole-Jan. (2014) Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase. Biochimica et Biophysica Acta - Molecular Basis of Disease. volum 1842 (5).
Vitenskapelig artikkel
Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Abdollahi, Pegah; Vansemb, Esten; Hagen, Lars; Baranowska, Katarzyna Anna; Misund, Kristine; Slupphaug, Geir; Børset, Magne. (2014) PRL-3 Mediates Survival of Primary Myeloma Cells. Blood. volum 124.
Sammendrag/abstract

2013

Galashevskaya, Anastasia; Sarno, Antonio; Vågbø, Cathrine Broberg; Aas, Per Arne; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2013) A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported. DNA Repair. volum 12 (9).
Vitenskapelig artikkel
Hu, Yi; Ericsson, Ida; Torseth, Kathrin; Methot, Stephen; Sundheim, Ottar; Liabakk, Nina-Beate; Slupphaug, Geir; Di Noia, Javier; Krokan, Hans Einar; Kavli, Bodil Merete. (2013) A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching. Journal of Molecular Biology (JMB). volum 425 (2).
Vitenskapelig artikkel
Johannessen, Helene; Kodama, Yosuke; Zhao, Chun-Mei; Sousa, Mirta; Slupphaug, Geir; Kulseng, Bård Eirik; Chen, Duan. (2013) Eating Behavior and Glucagon-Like Peptide-1-Producing Cells in Interposed Ileum and Pancreatic Islets in Rats Subjected to Ileal Interposition Associated with Sleeve Gastrectomy. Obesity Surgery. volum 23 (1).
Vitenskapelig artikkel
Johnsen, Anne Berit; Rolim, Natale Pinheiro Lage; Stølen, Tomas; Alves, Marcia; Sousa, Mirta; Slupphaug, Geir; Britton, Steven L; Koch, Lauren G; Smith, Godfrey L; Wisløff, Ulrik; Høydal, Morten Andre. (2013) Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity. PLOS ONE. volum 8 (10).
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Ericsson, Ida; Galashevskaya, Anastasia; Sarno, Antonio; Aas, Per Arne; Vagbo, CB; Pettersen, Henrik P Sahlin; Slupphaug, Geir. (2013) Genomic uracil - potent mutagen but normal intermediate in adaptive immunity. The FEBS Journal. volum 280.
Sammendrag/abstract
Sousa, Mirta; Zub, Kamila Anna; Aas, Per Arne; Hanssen-Bauer, Audun; Demirovic, Aida; Sarno, Antonio; Tian, Erming; Liabakk, Nina-Beate; Slupphaug, Geir. (2013) An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. PLOS ONE. volum 8 (2).
Vitenskapelig artikkel

2012

Doseth, Berit; Ekre, Cecilie; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2012) Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil. DNA Repair. volum 11 (6).
Vitenskapelig artikkel
Roberts, Victoria A.; Pique, Michael E.; Hsu, Simon; Li, Sheng; Slupphaug, Geir; Rambo, Robert P.; Jamison, Jonathan P.; Liu, Tong; Lee, Jun H.; Tainer, John A.; Ten Eyck, Lynn F.; Woods Jr., Virgil L.. (2012) Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Research (NAR). volum 40 (13).
Vitenskapelig artikkel
Steen, Kristian Wollen; Doseth, Berit; Westbye, Marianne Pedersen; Akbari, Mansour; Kang, D; Falkenberg, Maria; Slupphaug, Geir. (2012) mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored. DNA Repair. volum 11 (1).
Vitenskapelig artikkel
Torseth, Kathrin; Doseth, Berit; Hagen, Lars; Olaisen, Camilla; Liabakk, Nina-Beate; Græsmann, Heidi; Durandy, Anne; Otterlei, Marit; Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2012) The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA. DNA Repair. volum 11 (6).
Vitenskapelig artikkel

2011

Baglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda; Zub, Kamila; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Photochemical and Photobiological Sciences. volum 10 (7).
Vitenskapelig artikkel
Doseth, Berit; Visnes, Torkild; Wallenius, Anders; Ericsson, Ida; Sarno, Antonio; Pettersen, Henrik Sahlin; Flatberg, Arnar; Catterall, Tara Cherie; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2011) Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE. Journal of Biological Chemistry. volum 286 (19).
Vitenskapelig artikkel
Hanssen-Bauer, Audun; Solvang-Garten, Karin; Sundheim, Ottar; Diaz, Javier Pena; Andersen, Sonja Benedikte; Slupphaug, Geir; Krokan, Hans Einar; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2011) XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage. Environmental and Molecular Mutagenesis. volum 52 (8).
Vitenskapelig artikkel
Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Research (NAR). volum 39 (19).
Vitenskapelig artikkel
Sousa, Mirta; Steen, Kristian Wollen; Hagen, Lars; Slupphaug, Geir. (2011) Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis. Proteome Science. volum 9.
Vitenskapelig artikkel
Zeitlin, SG; Chapados, BR; Baker, NM; Tai, C; Slupphaug, Geir; Wang, JYJ. (2011) Uracil DNA N-Glycosylase Promotes Assembly of Human Centromere Protein A. PLOS ONE. volum 6 (3).
Vitenskapelig artikkel

2010

Bergstrøm, Bjarte Aune; Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit Walbye. (2010) Identification of a Novel in Vivo Virus-targeted Phosphorylation Site in Interferon Regulatory Factor-3 (IRF3). Journal of Biological Chemistry. volum 285 (32).
Vitenskapelig artikkel
Felberg, Hanne Solvang; Hagen, Lars; Slupphaug, Geir; Batista, Irineu; Nunes, Maria Leonora; Olsen, Ragnar Ludvig; Martinez, iciar. (2010) Partial characterisation of gelatinolytic activities in herring (Clupea harengus) and sardine (Sardina pilchardus) possibly involved in post-mortem autolysis of ventral muscle. Food Chemistry. volum 119 (2).
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Otterlei, Marit; Akbari, M.; Slupphaug, Geir; Aas, Per Arne. (2010) DNA repair and cancer. European Journal of Cancer. volum 8 (5).
Sammendrag/abstract
Monsen, Vivi A Talstad; Sundheim, Ottar; Aas, Per Arne; Westbye, Marianne Pedersen; Sousa, Mirta; Slupphaug, Geir; Krokan, Hans Einar. (2010) Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3. Nucleic Acids Research (NAR). volum 38 (19).
Vitenskapelig artikkel

2009

Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology. volum 186 (5).
Vitenskapelig artikkel
Knaevelsrud, I; Knaevelsrud, I; Slupphaug, G; Leiros, Ingar; Matsuda, A; Ruoff, P; Ruoff, P; Bjelland, S; Bjelland, S. (2009) Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology. volum 85 (5).
Vitenskapelig artikkel
Knævelsrud, I.; Slupphaug, Geir; Leiros, Ingar; Matsuda, A.; Ruoff, Peter; Bjelland, Svein. (2009) Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology. volum 85 (5).
Vitenskapelig artikkel
Langevin, C; Maidou-Peindara, P; Aas, Per Arne; Jacquot, G; Otterlei, Marit; Slupphaug, Geir; Benichou, S. (2009) Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect. Journal of Virology. volum 83 (19).
Vitenskapelig artikkel
Visnes, Torkild; Doseth, Berit; Pettersen, Henrik Sahlin; Hagen, Lars; Sousa, Mirta; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2009) Uracil in DNA and its processing by different DNA glycosylases. Philosophical Transactions of the Royal Society of London. Biological Sciences. volum 364 (1517).
Vitenskapelig oversiktsartikkel/review

2008

Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Liabakk, Nina-Beate; Sundheim, Ottar; Diaz, Javier Pena; Otterlei, Marit; Hørning, Ole; Jensen, Ole N; Krokan, Hans Einar; Slupphaug, Geir. (2008) Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO Journal. volum 27 (1).
Vitenskapelig artikkel
Sundheim, Ottar; Talstad, Vivi A; Vågbø, Cathrine Broberg; Slupphaug, Geir; Krokan, Hans Einar. (2008) AlkB demethylases flip out in different ways. DNA Repair. volum 7 (11).
Vitenskapelig artikkel
Visnes, Torkild; Akbari, Mansour; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2008) The rate of base excision repair of uracil is controlled by the initiating glycosylase. DNA Repair. volum 7 (11).
Vitenskapelig artikkel
Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate; Slupphaug, Geir; Otterlei, Marit; Krokan, Hans Einar. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry. volum 238 (36).
Vitenskapelig artikkel

2007

Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology. volum 8 (6).
Vitenskapelig oversiktsartikkel/review
Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) Uracil in DNA - General mutagen, but normal intermediate in acquired immunity. DNA Repair.
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Akbari, Mansour; Visnes, Torkild; Pettersen, Henrik P Sahlin; Sundheim, Ottar; Hagen, Lars; Otterlei, Marit; Gilljam, Karin Margaretha; Slupphaug, Geir. (2007) Repair og uracil in DNA by UNG2 and SMUG1 - an update. DNA Repair.
Sammendrag/abstract
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA - From molecular biology to phenotype - Preface. DNA Repair. volum 6.
Leder
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA- from molecular biology to phenotype. DNA Repair. volum 6 (4).
Sammendrag/abstract
Lu, CC; Huang, HT; Wang, JT; Slupphaug, Geir; Li, TK; Wu, MC; Chen, YC; Lee, CP; Chen, MR. (2007) Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication. Journal of Virology. volum 81.
Vitenskapelig artikkel
Parsons, Jason L.; Kavli, Bodil Merete; Slupphaug, Geir; Dianov, Grigory L.. (2007) NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break. Biochemistry. volum 46 (13).
Vitenskapelig artikkel
Pettersen, Henrik P Sahlin; Sundheim, Ottar; Gilljam, Karin Margaretha; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2007) Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms. Nucleic Acids Research (NAR). volum 35 (12).
Vitenskapelig artikkel
Sousa, Mirta; Krokan, Hans Einar; Slupphaug, Geir. (2007) DNA-uracil and human pathology. Molecular Aspects of Medicine. volum 28.
Vitenskapelig oversiktsartikkel/review

2006

Hagen, Lars; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2006) Genomic uracil and human disease. Experimental Cell Research. volum 312.
Vitenskapelig oversiktsartikkel/review
Krokan, Hans Einar; Akbari, Mansour; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Ericsson, Madelene; Aarset, Harald; Andersen, Sonja Benedikte; Slupphaug, Geir. (2006) Base excision repair proteins in cancer prevention and acquired immune responses. The FEBS Journal. volum 273.
Sammendrag/abstract
Krokan, Hans Einar; Slupphaug, Geir. (2006) Preface. DNA Repair.
Vitenskapelig artikkel
Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Mittelstedt, L.Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO Journal. volum 25.
Vitenskapelig artikkel

2005

Andersen, Sonja Benedikte; Ericsson, Maria Elisabeth Madelene; Dai, HY; Diaz, Javier Pena; Slupphaug, Geir; Nilsen, H; Aarset, H; Krokan, Hans Einar. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair. volum 4 (12).
Vitenskapelig artikkel
Kavli, Bodil Merete; Andersen, Sonja Benedikte; Otterlei, Marit; Liabakk, Nina-Beate; Imai, K; Fischer, A; Durandy, A; Krokan, Hans Einar; Slupphaug, Geir. (2005) B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Journal of Experimental Medicine (JEM). volum 201.
Vitenskapelig artikkel
Zeitlin, SG; Patel, S; Kavli, Bodil Merete; Slupphaug, Geir. (2005) Xenopus CENP - A assembly into chromatin requires base excision repair proteins. DNA Repair. volum 4.
Vitenskapelig artikkel
Andersen, S; Ericsson, M; DAI, H; Peña-Diaz, J; Slupphaug, G; Nilsen, Hilde; Aarset, H; Krokan, HE. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair. volum 4 (12).
Vitenskapelig artikkel

2004

Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Aas, Per Arne; Kavli, Bodil; Liabakk, Nina-Beate; Hagen, Lars; Imai, K; Durandy, A; Slupphaug, Geir; Krokan, Hans Einar. (2004) Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells. Nucleic Acids Research (NAR). volum 32.
Vitenskapelig artikkel
Diaz, Javier Pena; Akbari, Mansour; Sundheim, Ottar; Farez-Vidal, ME; Andersen, S; Sneve, R; Gonzalez-Pacanowska, D; Krokan, Hans Einar; Slupphaug, Geir. (2004) Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair. Journal of Molecular Biology (JMB). volum 342.
Vitenskapelig artikkel
Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair. volum 3 (11).
Vitenskapelig oversiktsartikkel/review
Krokan, Hans Einar; Slupphaug, Geir. (2004) Novel aspects of macromolecular repair and relationship to human disease. Journal of Molecular Medicine. volum 82.
Vitenskapelig oversiktsartikkel/review

2003

Imai, K; Slupphaug, Geir; Lee, W-I; Revy, P; Nonoyama, S; Catalan, N; Yel, L; Forveille, M; Kavli, Bodil; Krokan, Hans Einar; Ochs, H.D; Fischer, A; Durandy, A. (2003) Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch. Nature Immunology. volum 4.
Vitenskapelig artikkel
Slupphaug, Geir; Kavli, Bodil; Krokan, Hans Einar. (2003) Interacting pathways that prevent and repair oxidative DNA damage. Mutation Research (DNA Repair). volum 531.
Vitenskapelig artikkel
Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen; Krokan, Hans Einar. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature. volum 421.
Vitenskapelig artikkel

2002

Johansen, Tor Arne; Petersen, Idar; Slupphaug, Geir. (2002) Explicit sub-optimal linear quadratic regulation with state and input constraints. Automatica. volum 38.
Vitenskapelig artikkel
Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Skorpen, Frank; Aas, Per Arne; Hagen, Lars; Krokan, Hans Einar; Slupphaug, Geir. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry. volum 18.
Vitenskapelig artikkel
Krokan, Hans Einar; Drabløs, Finn; Slupphaug, Geir. (2002) Uracil in DNA, occurrence, consequences and repair. Oncogene. volum 21.
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2002) Damage and repair of DNA in mammalian cells-emphasis on oxidative damage. Proceedings from International Symposium "Natural Ionising Radiation and Health". Det Norske Videnskaps-Akademi : proceedings.
Vitenskapelig artikkel
Nygård, M; Nilsen, M; Remseth, V; Slupphaug, Geir; Krokan, Hans Einar. (2002) Uttrykk av det membran-modifiserende enzymet UDPDG i E.coli som funksjon av dyrkningsbetingelser og induksjon av DNA-skader. 2002.
Hovedfagsoppgave
Grøsvik, K; Slupphaug, Geir; Krokan, Hans Einar. (2002) "Characterisation of uracil-exising enzyme activities in organ extracts from UNG knockout and wild-type mice.". 2002.
Hovedfagsoppgave

2001

Cappelli, E.; Hazra, T.; Hill, J.; Slupphaug, Geir; Bobliolo, M.; Frosina, G.. (2001) Rates of base excision repair are not solely dependent on levels of initiating enzymes. Carcinogenesis. volum 22.
Vitenskapelig artikkel
Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Skjelbred, Camilla Furu; Akbari, Mansour; Aas, Per Arne; Slupphaug, Geir. (2001) Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology. volum 68.
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (2001) Efficient Optimal Prioritized Infeasibility Handling in Model Predictive Control - A Parametric Preemptive Multi-objective Linear Programming Approach. Journal of Optimization Theory and Applications.
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne; Foss, Bjarne Anton. (2001) Linear MPC with Optimal Prioritized Infeasibility Handling: Application, Computational Issues and Stability. Automatica. volum 37.
Vitenskapelig artikkel

2000

Imsland, Lars Struen; Slupphaug, Geir; Foss, Bjarne Anton. (2000) Robust output feedback control for constrained discrete-time nonlinear systems using observer-based controllers. 2000.
Rapport
Johansen, Tor Arne; Slupphaug, Geir. (2000) Comment on "Stability issues on Takagi-Sugeno fuzzy model - parametric approach". IEEE transactions on fuzzy systems. volum 8.
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, H.; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair in mammalian cells. FEBS Letters.
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, Hilde; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters.
Vitenskapelig artikkel
Nilsen, Hilde; Rosewell, I.; Robins, P.; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Krokan, Hans Einar; Lindahl, T.; Barnes, D.E.. (2000) ) Ung-deficient mice reveal a primary role of the uracil-DNA glycosylase enzyme during DNA replication. Molecular Cell.
Vitenskapelig artikkel
Nilsen, Hilde; Rosewell, Ian; Robins, Peter; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Daly, Graham; Krokan, Hans Einar; Lindahl, Tomas; Barnes, Deborah E.. (2000) URACIL-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication. Molecular Cell. volum 5.
Vitenskapelig artikkel
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR).
Vitenskapelig artikkel
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR).
Vitenskapelig artikkel
Parikh, S; Walcher, G; Jones, G.D; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.M; Tainer, J.A. (2000) Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America.
Vitenskapelig artikkel
Parikh, Sudip S.; Walcher, Gunter; Jones, Garry D.; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.Michael; Tainer, John A.. (2000) Uracil-DNA glycosylase-DNA substrate and product structures:Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America. volum 97.
Vitenskapelig artikkel
Slupphaug, Geir; Foss, Bjarne Anton. (2000) Nonlinear robust constrained control of partially uncontrollable and open-loop unstable systems. Journal of Process Control. volum 10.
Vitenskapelig artikkel
Slupphaug, Geir; Imsland, Lars Struen; Foss, Bjarne Anton. (2000) Uncertainty modelling and robust output feedback control of nonlinear discrete systems: a mathematical programming approach. International Journal of Robust and Nonlinear Control. volum 10.
Vitenskapelig artikkel

1999

Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bhariti, Sangeeta; Steinsbekk, Kristin; Nilsen, Hilde; Skjelbred, Camilla; Kavli, Bodil; Standal, Rune; Slupphaug, Geir. (1999) Human uracil-DNA glycosylase. NATO Advances Study Institute series. Series A, Life sciences. volum 302.
Vitenskapelig artikkel
Otterlei, Marit; Warbrick, Emma; Nagelhus, Toril; Haug, Terje; Slupphaug, Geir; Akbari, Mansour; Aas, Per Arne; Steinsbekk, Kristin; Bakke, Oddmund; Krokan, Hans Einar. (1999) Post-replicative base excision repair in replication foci. EMBO Journal. volum 18 (13).
Vitenskapelig artikkel
Slupphaug, Geir; Foss, Bjarne Anton. (1999) Constrained quadratic stabilization of discrete-time uncertain non-linear multi-model systems using piecewise affine state-feedback. International Journal of Control. volum 72 (7/8).
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (1999) Efficient optimal prioritized infeasibility handling in model predictive control - a parametric preemptive multi-objective linear programming approach. 1999.
Rapport

1998

Bharati, S.; Krokan, Hans Einar; Kristiansen, L; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites. Nucleic Acids Research (NAR).
Vitenskapelig artikkel
Krokan, Hans Einar; Parikh, S.S.; Slupphaug, Geir; Bharati, S; Trainer, J.A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO Journal. volum 1998.
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (1998) DNA-reparasjonsenzymer og deres gener. Tidsskrift for Den norske legeforening. volum 118.
Vitenskapelig artikkel
Otterlei, Marit; Haug, T.; Nagelhus, T.A; Slupphaug, Geir; Lindmo, T.; Krokan, Hans Einar. (1998) Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively. Nucleic Acids Research (NAR). volum 26 (20).
Vitenskapelig artikkel
Parikh, S. Sudip; Mol, Clifford D.; Slupphaug, Geir; Bharati, Sangeta; Krokan, Hans Einar; Yainer, John A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase. EMBO Journal. volum 17.
Vitenskapelig artikkel
Slupphaug, Geir. (1998) On robust constrained nonlinear control and hybrid control : BMI and MPC based state-feedback schemes. 1998. ISBN 82-471-0295-1. ITK-rapport & 1998:13-W.
Doktorgradsavhandling

1997

Krokan, Hans Einar; Standal, Rune; Bharati, Sangeeta; Otterlei, Marit; Haug, Terje; Slupphaug, Geir; Skorpen, Frank. (1997) Uracil in DNA and the family of concerved uracil DNA glycosylases. Base excision repair on DNA damage.
Vitenskapelig kapittel/artikkel
Krokan, Hans Einar; Standal, Rune; Slupphaug, Geir. (1997) DNA glycosylase in the base excision repair of DNA. Biochemical Journal. volum 325.
Vitenskapelig artikkel

1996

Bouhamdan, M; Benichou, S.; Rey, F.; Navarro, J.M.; Agostini, I.; Spire, B.; Camanis, G.; Slupphaug, Geir; Vigne, R; Benarous, R; Sire, J.. (1996) Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme. Journal of Virology.
Vitenskapelig artikkel
Dizdaroglu, M.; Karakaya, A.; Jaruga, P.; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR).
Vitenskapelig artikkel
Dizdaroglu, Miral; Karakaya, Asuman; Jaruga, Pawel; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR). volum 24 (3).
Vitenskapelig artikkel
Kavli, B.; Slupphaug, Geir; Mol, C.D.; Arvai, A.S.; Petersen, S.B.; Tainer, J.A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal.
Vitenskapelig artikkel
Kavli, Bodil; Slupphaug, Geir; Mol, Clifford D.; Arvai, Andrew S.; Petersen, Steffen B.; Tainer, John A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal. volum 15 (13).
Vitenskapelig artikkel
Nagelhus, T.; Slupphaug, Geir; Krokan, Hans Einar; Lindmo, T.. (1996) Fading correction for fluorescence quantitation in confocal microscopy. Cytometry.
Vitenskapelig artikkel
Slupphaug, Geir; Foss, Bjarne Anton. (1996) Model predictive control for a class of hybrid systems. 1996. Rapport (96-46).
Rapport
Slupphaug, Geir; Kavli, B.; Mol, C.D.; Arvai, A.; Krokan, Hans Einar; Tainer, J.A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature.
Vitenskapelig artikkel
Slupphaug, Geir; Mol, Clifford D.; Kavli, Bodil; Arvai, Andrew S.; Krokan, Hans Einar; Tainer, John A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature. volum 384 (7. Nove).
Vitenskapelig artikkel

1995

Slupphaug, Geir. (1995) A brief introduction to some logics, formal languages and Petri net theory. 1995. Rapport (95-45-W).
Rapport
Slupphaug, Geir. (1995) A note on hybrid systems emphasizing approaches in the control community. 1995. Rapport (95-46-W).
Rapport
Slupphaug, Geir; Eftedal, Ingrid; Kavli, Bodil; Bharati, Sangeeta; Helle, Nils M; Haug, Terje; Levine, David William; Krokan, Hans Einar. (1995) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry. volum 34.
Vitenskapelig artikkel
Slupphaug, Geir; Halvorsen, Ivar. (1995) Forprosjekt: Regulering og overvåking av komplekse industrianlegg. 1995. Rapport (95-29-P).
Rapport

1993

Iversen, Tor-Henning; Bones, Atle M.; Slupphaug, Geir. (1993) Bioteknologi - 2 timers valgfag. Gyldendal Akademisk. 1993.
Fagbok
Slupphaug, G.; Markussen, F.-H.; Olsen, Lisbeth Charlotte; Aasland, Rein; Aarsæther, Niels; Bakke, O.; Krokan, H. E.; Helland, Dag Emil. (1993) Human Uracil-DNA glycosylase is shared by the nucleus and the mitochondria. Nucleic Acid Res. volum 21.
Vitenskapelig artikkel
Eftedal, Ingrid; Guddal, Per Henrik; Slupphaug, Geir; Volden, Gunnar; Krokan, Hans Einar. (1993) Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase. Nucleic Acids Research (NAR). volum 21 (9).
Vitenskapelig artikkel
Slupphaug, Geir; Alseth, Ingrun; Eftedal, Ingrid; Volden, Gunnar; Krokan, Hans Einar. (1993) Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification. Analytical Biochemistry. volum 211.
Vitenskapelig artikkel

1991

Slupphaug, G.; Olsen, Lisbeth Charlotte; Helland, Dag Emil; Aasland, Rein; Krokan, H. E.. (1991) Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil- DNA glycosylase. Nucleic Acids Research (NAR). volum 19.
Vitenskapelig artikkel

1990

Thangstad, Ole Petter; Iversen, Tor-Henning; Slupphaug, Geir; Bones, Atle M.. (1990) Immunocytochemical localization of myrosinase. Planta.
Vitenskapelig artikkel

Vitenskapelige artikler

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari A.. (2022) MS-proteomics provides insight into the host responses towards alginate microspheres. Materials Today Bio. volum 17.
Vitenskapelig artikkel
Alswady-Hoff, Mayes; Erdem, Johanna Maria Samulin; Phuyal, Santosh; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Skare, Øivind; Slupphaug, Geir; Zienolddiny, Shanbeh. (2021) Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells. International Journal of Molecular Sciences. volum 22 (10).
Vitenskapelig artikkel
Alves, Christiano R. R.; Eichelberger, Eric J.; das Neves, Willian; Ribeiro, Márcio A. C.; Bechara, Luiz R.G.; Voltarelli, Vanessa A.; de Almeida, Ney R.; Hagen, Lars; Sharma, Animesh; Ferreira, Julio C. B.; Swoboda, Kathryn J.; Slupphaug, Geir; Brum, Patricia C.. (2021) Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity. The FASEB Journal. volum 35 (7).
Vitenskapelig artikkel
Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Fernandez Berrocal, Marion Silvana; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna; Olsen, Ann-Karin Hardie; Gutzkow, Kristine Bjerve; Rowe, Alexander D.; Wang, Wei; Moldestad, Olve; Syrstad, Monica Dahl; Slupphaug, Geir; Eide, Lars; Klungland, Arne; Sætrom, Pål; Luna, Luisa; Ye, Jing; Scheffler, Katja; Bjørås, Magnar. (2021) NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. Communications Biology. volum 4.
Vitenskapelig artikkel
Kavli, Bodil Merete; Iveland, Tobias Solli; Buchinger, Edith; Hagen, Lars; Liabakk, Nina-Beate; Aas, Per Arne; Obermann, Tobias Sebastian; Aachmann, Finn Lillelund; Slupphaug, Geir. (2021) RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork. Nucleic Acids Research (NAR). volum 49 (7).
Vitenskapelig artikkel
Olinski, Ryszard; Slupphaug, Geir; Foksinski, Marek; Krokan, Hans Einar. (2021) Genomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignancies. International Journal of Molecular Sciences. volum 22 (8).
Vitenskapelig artikkel
Steen, Kristian Wollen; Hagen, Lars; Vågbø, Cathrine Broberg; Rabe, Renana; Iveland, Tobias Solli; Aas, Per Arne; Sharma, Animesh; Sporsheim, Bjørnar; Erlandsen, Hilde; Palibrk, Vuk; Bjørås, Magnar; Fonseca, Davi de Miranda; Mosammaparast, Nima; Slupphaug, Geir. (2021) ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA. Journal of Translational Medicine. volum 19 (1).
Vitenskapelig artikkel
Wang, Qiong; Karvelsson, Sigurdur Trausti; Johannsson, Freyr; Vilhjalmsson, Arnar Ingi; Hagen, Lars; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Rolfsson, Ottar. (2021) UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines. Molecular Oncology.
Vitenskapelig artikkel
Alves, Christiano R. R.; des Neves, Willian; de Almeida, Ney R; Eichelberger, Eric J; Jannig, Paulo R.; Voltarelli, Vanessa A; Tobias, Gabriel C; Bechara, Luiz R G; de Paula Faria, Daniele; Alves, Maria J N; Hagen, Lars; Sharma, Animesh; Slupphaug, Geir; Moreira, Jose Bianco Nascimento; Wisløff, Ulrik; Hirshman, Michael F.; Negrao, Carlos E.; de Castro Jr, Gilberto; Chammas, Roger; Swoboda, Kathryn J.; Ruas, Jorge L.; Goodyear, Laurie J.; Brum, Patricia Chakur. (2020) Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN. Molecular Metabolism.
Vitenskapelig artikkel
Eldin, Patrick; Péron, Sophie; Galashevskaya, Anastasia; Denis-Lagache, Nicolas; Cogné, Michel; Slupphaug, Geir; Briant, Laurence. (2020) Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination. Journal of Translational Medicine. volum 18 (1).
Vitenskapelig artikkel
Iveland, Tobias Solli; Hagen, Lars; Sharma, Animesh; Sousa, Mirta; Sarno, Antonio; Wollen, Kristian Lied; Liabakk, Nina-Beate; Slupphaug, Geir. (2020) HDACi Mediate UNG2 Depletion, Dysregulated Genomic Uracil and Altered Expression of Oncoproteins and Tumor Suppressors in B- And T-cell Lines. Journal of Translational Medicine. volum 18.
Vitenskapelig artikkel
Vågbø, Cathrine Broberg; Slupphaug, Geir. (2020) RNA in DNA repair. DNA Repair. volum 95.
Vitenskapelig artikkel
Yang, Rui; Elsaadi, Samah; Misund, Kristine; Abdollahi, Pegah; Vandsemb, Esten; Moen, Siv Helen; Kusnierczyk, Anna; Slupphaug, Geir; Standal, Therese; Waage, Anders; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Rustad, Even Holth; Sundan, Anders; Hay, Carl; Cooper, Zachary; Schuller, Alwin G.; Woessner, Richard; Borodowski, Alexandra; Menu, Eline; Børset, Magne; Sponaas, Anne-Marit. (2020) Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade. Journal for ImmunoTherapy of Cancer (JITC).
Vitenskapelig artikkel
Macur, Katarzyna; Hagen, Lars; Ciesielski, Tomasz Maciej; Konieczna, Lucyna; Skokowski, Jaroslaw; Jenssen, Bjørn Munro; Slupphaug, Geir; Baczek, Tomasz. (2019) A targeted mass spectrometry immunoassay to quantify osteopontin in fresh-frozen breast tumors and adjacent normal breast tissues. Journal of Proteomics. volum 208.
Vitenskapelig artikkel
Pinto, Rita; Vågbø, Cathrine Broberg; Jakobsson, Magnus; Yeji, Kim; Baltissen, Marijke P; O'Donohue, Marie-Francoise; Guzman, Ulises H; Malecki, Jedrzej Mieczyslaw; Wu, Jie; Kirpekar, Finn; Olsen, Jesper V; Gleizes, Pierre-Emmanuel; Vermeulen, Michiel; Leidel, Sebastian A.; Slupphaug, Geir; Falnes, Pål Øystein. (2019) The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Nucleic Acids Research (NAR). volum 48 (2).
Vitenskapelig artikkel
Steinacher, Roland; Barekati, Zeinab; Botev, Petar; Kusnierczyk, Anna; Slupphaug, Geir; Schär, Primo. (2019) SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation. EMBO Journal. volum 38 (1).
Vitenskapelig artikkel
Phuyal, Santosh; Kasem, Mayes; Knittelfelder, Oskar; Sharma, Animesh; Fonseca, Davi de Miranda; Vebraite, Vaineta; Shaposhnikov, Sergey; Slupphaug, Geir; Skaug, Vidar; Zienolddiny, Shanbeh. (2018) Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes. Nanotoxicology. volum 12 (2).
Vitenskapelig artikkel
Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Alves, Marcia Netto Magalhaes; Wohlwend, Martin; Gebriel, Mohammed; Hagen, Lars; Sharma, Animesh; Koch, Lauren G.; Britton, Steven L.; Slupphaug, Geir; Wisløff, Ulrik; Brum, Patricia C.. (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Scientific Reports. volum 8 (1).
Vitenskapelig artikkel
Brickner, Joshua R; Soll, Jennifer M; Lombardi, Patrick M; Vågbø, Cathrine Broberg; Mudge, Miranda C; Oyeniran, Clement; Rabe, Renana; Jackson, Jessica; Sullender, Meagan E; Blazosky, Elyse; Byrum, Andrea K; Zhao, Yu; Corbett, Mark A.; Gècz, Jozef; Field, Michael; Vindigni, Alessandro; Slupphaug, Geir; Wolberger, Cynthia; Mosammaparast, Nima. (2017) A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. volum 551 (7680).
Vitenskapelig artikkel
Buchinger, Edith; Wiik, Siv Åshild; Kusnierczyk, Anna; Rabe, Renana; Aas, Per Arne; Kavli, Bodil Merete; Slupphaug, Geir; Aachmann, Finn Lillelund. (2017) Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2. Biomolecular NMR Assignments. volum 12 (1).
Vitenskapelig artikkel
Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar; Finsen, Alexandra. (2017) NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports. volum 18.
Vitenskapelig artikkel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel. Data in Brief. volum 12.
Vitenskapelig artikkel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit. (2017) On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay. Analytical Biochemistry. volum 523.
Vitenskapelig artikkel
Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja; Neurauter, Christine Gran; Esbensen, Qin Ying; Kusnierczyk, Anna; Hildrestrand, Gunn Annette; Graupner, Anne; Andersen, Jill Mari; Slupphaug, Geir; Klungland, Arne; Nilsen, Hilde; Bjørås, Magnar. (2017) No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Scientific Reports. volum 7.
Vitenskapelig artikkel
Rydning, Siri Lynne; Backe, Paul Hoff; Sousa, Mirta; Iqbal, Zafar; Øye, Ane-Marte; Sheng, Ying; Yang, Mingyi; Lin, Xiaolin; Slupphaug, Geir; Nordenmark, Tonje Haug; Vigeland, Magnus Dehli; Bjørås, Magnar; Tallaksen, Chantal; Selmer, Kaja Kristine. (2017) Novel UCHL1 mutations reveal new insights into ubiquitin processing. Human Molecular Genetics. volum 26 (6).
Vitenskapelig artikkel
Zatula, Alexey; Dikic, Aida; Mulder, Teska Celine; Sharma, Animesh; Vågbø, Cathrine Broberg; Sousa, Mirta; Waage, Anders; Slupphaug, Geir. (2017) Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia. OncoTarget. volum 8 (12).
Vitenskapelig artikkel
Helander, Linda; Sharma, Animesh; Krokan, Hans Einar; Plaetzer, Kristjan; Krammer, Barbara; Tortik, Nicole; Gederaas, Odrun Arna; Slupphaug, Geir; Hagen, Lars. (2016) Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins. Molecular Biosystems.
Vitenskapelig artikkel
Iversen, Ole-Jan; Lysvand, Hilde; Slupphaug, Geir. (2016) Pso p27, a SERPINB3/B4-derived protein, is most likely a common autoantigen in chronic inflammatory diseases. Clinical Immunology. volum 174.
Vitenskapelig artikkel
Skarpengland, Tonje; Dahl, Tuva Børresdatter; Skjelland, Mona; Scheffler, Katja; Sousa, Mirta; Gregersen, Ida; Kusnierczyk, Anna; Sharma, Animesh; Slupphaug, Geir; Eide, Lars; Segers, Filip; Skagen, Karolina Ryeng; Dahl, Christen Peder; Russell, David; Folkersen, Lasse; Krohg-Sørensen, Kirsten; Holm, Sverre; Bjørås, Magnar; Aukrust, Pål; Halvorsen, Bente. (2016) Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA. Free Radical Biology & Medicine. volum 97.
Vitenskapelig artikkel
Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna; Ketelhuth, Daniel F.J.; Lundberg, Anna M.; Neurauter, Christine Gran; Hildrestrand, Gunn Annette; Skjelland, Mona; Bjørndal, Bodil; Svardal, Asbjørn M.; Iversen, Per Ole; Hedin, Ulf; Nygård, Ståle; Olstad, Ole Kristoffer; Krohg-Sørensen, Kirsten; Slupphaug, Geir; Eide, Lars; Kusnierczyk, Anna; Folkersen, Lasse; Ueland, Thor; Berge, Rolf Kristian; Hansson, Göran K.; Biessen, Erik A.L.; Halvorsen, Bente; Bjørås, Magnar; Aukrust, Pål. (2016) Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice. Scientific Reports. volum 6:28337.
Vitenskapelig artikkel
Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne; Bjørås, Magnar. (2015) Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports. volum 13 (12).
Vitenskapelig artikkel
Kataya, Amr Ramzy Abass; Heidari Ahootapeh, Behzad; Hagen, Lars; Kommedal, Roald; Slupphaug, Geir; Lillo, Cathrine. (2015) Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Plant Physiology. volum 167 (2).
Vitenskapelig artikkel
Kataya, Amr Ramzy Abass; Heidari, Behzad; Hagen, Lars; Kommedal, Roald; Slupphaug, Geir; Lillo, Cathrine. (2015) Supplemental materials for: Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Plant Physiology. volum 167 (2).
Vitenskapelig artikkel
Lysvand, Hilde; Helland, Ronny; Hagen, Lars; Slupphaug, Geir; Iversen, Ole-Jan. (2015) Psoriasis pathogenesis – Pso p27 constitutes a compact structure forming large aggregates. Biochemistry and Biophysics Reports. volum 2.
Vitenskapelig artikkel
Mjelle, Robin; Hegre, Siv Anita; Aas, Per Arne; Slupphaug, Geir; Drabløs, Finn; Sætrom, Pål; Krokan, Hans Einar. (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair. volum 30.
Vitenskapelig artikkel
Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål; Kavli, Bodil Merete; Krokan, Hans Einar. (2015) AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA Repair. volum 25.
Vitenskapelig artikkel
Rolim, Natale Pinheiro Lage; Skårdal, Kristine; Høydal, Morten; Sousa, Mirta; Malmo, Vegard; Skrove, Guri Kaurstad; Ingul, Charlotte Bjørk; Hansen, Harald Edvard Mølmen; Alves, Marcia Netto Magalhaes; Thuen, Marte; Haraldseth, Olav; Brum, Patricia Chakur; Slupphaug, Geir; Loennechen, Jan Pål; Stølen, Tomas; Wisløff, Ulrik. (2015) Aerobic interval training reduces inducible ventricular arrhytmias in diabetic mice after myocardial infarction. Basic Research in Cardiology. volum 110 (44).
Vitenskapelig artikkel
Zub, Kamila; Sousa, Mirta; Sarno, Antonio; Sharma, Animesh; Dikic, Aida; Rao, Shalini; Young, Clifford; Aas, Per Arne; Ericsson, Ida; Sundan, Anders; Jensen, Ole Nørregaard; Slupphaug, Geir. (2015) Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired Melphalan resistance in multiple myeloma cells. PLOS ONE. volum 10 (3).
Vitenskapelig artikkel
Hagen, Lars; Sharma, Animesh; Aas, Per Arne; Slupphaug, Geir. (2014) Off-target responses in the HeLa proteome subsequent to transient plasmid-mediated transfection. Biochimica et Biophysica Acta - Proteins and Proteomics. volum 1854 (1).
Vitenskapelig artikkel
Krokan, Hans Einar; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Kavli, Bodil Merete; Slupphaug, Geir. (2014) Error-free versus mutagenic processing of genomic uracil-Relevance to cancer. DNA Repair. volum 19.
Vitenskapelig artikkel
Lysvand, Hilde; Hagen, Lars; Klubicka, Lidija; Slupphaug, Geir; Iversen, Ole-Jan. (2014) Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase. Biochimica et Biophysica Acta - Molecular Basis of Disease. volum 1842 (5).
Vitenskapelig artikkel
Galashevskaya, Anastasia; Sarno, Antonio; Vågbø, Cathrine Broberg; Aas, Per Arne; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2013) A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported. DNA Repair. volum 12 (9).
Vitenskapelig artikkel
Hu, Yi; Ericsson, Ida; Torseth, Kathrin; Methot, Stephen; Sundheim, Ottar; Liabakk, Nina-Beate; Slupphaug, Geir; Di Noia, Javier; Krokan, Hans Einar; Kavli, Bodil Merete. (2013) A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching. Journal of Molecular Biology (JMB). volum 425 (2).
Vitenskapelig artikkel
Johannessen, Helene; Kodama, Yosuke; Zhao, Chun-Mei; Sousa, Mirta; Slupphaug, Geir; Kulseng, Bård Eirik; Chen, Duan. (2013) Eating Behavior and Glucagon-Like Peptide-1-Producing Cells in Interposed Ileum and Pancreatic Islets in Rats Subjected to Ileal Interposition Associated with Sleeve Gastrectomy. Obesity Surgery. volum 23 (1).
Vitenskapelig artikkel
Johnsen, Anne Berit; Rolim, Natale Pinheiro Lage; Stølen, Tomas; Alves, Marcia; Sousa, Mirta; Slupphaug, Geir; Britton, Steven L; Koch, Lauren G; Smith, Godfrey L; Wisløff, Ulrik; Høydal, Morten Andre. (2013) Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity. PLOS ONE. volum 8 (10).
Vitenskapelig artikkel
Sousa, Mirta; Zub, Kamila Anna; Aas, Per Arne; Hanssen-Bauer, Audun; Demirovic, Aida; Sarno, Antonio; Tian, Erming; Liabakk, Nina-Beate; Slupphaug, Geir. (2013) An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. PLOS ONE. volum 8 (2).
Vitenskapelig artikkel
Doseth, Berit; Ekre, Cecilie; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2012) Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil. DNA Repair. volum 11 (6).
Vitenskapelig artikkel
Roberts, Victoria A.; Pique, Michael E.; Hsu, Simon; Li, Sheng; Slupphaug, Geir; Rambo, Robert P.; Jamison, Jonathan P.; Liu, Tong; Lee, Jun H.; Tainer, John A.; Ten Eyck, Lynn F.; Woods Jr., Virgil L.. (2012) Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Research (NAR). volum 40 (13).
Vitenskapelig artikkel
Steen, Kristian Wollen; Doseth, Berit; Westbye, Marianne Pedersen; Akbari, Mansour; Kang, D; Falkenberg, Maria; Slupphaug, Geir. (2012) mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored. DNA Repair. volum 11 (1).
Vitenskapelig artikkel
Torseth, Kathrin; Doseth, Berit; Hagen, Lars; Olaisen, Camilla; Liabakk, Nina-Beate; Græsmann, Heidi; Durandy, Anne; Otterlei, Marit; Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2012) The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA. DNA Repair. volum 11 (6).
Vitenskapelig artikkel
Baglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda; Zub, Kamila; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Photochemical and Photobiological Sciences. volum 10 (7).
Vitenskapelig artikkel
Doseth, Berit; Visnes, Torkild; Wallenius, Anders; Ericsson, Ida; Sarno, Antonio; Pettersen, Henrik Sahlin; Flatberg, Arnar; Catterall, Tara Cherie; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2011) Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE. Journal of Biological Chemistry. volum 286 (19).
Vitenskapelig artikkel
Hanssen-Bauer, Audun; Solvang-Garten, Karin; Sundheim, Ottar; Diaz, Javier Pena; Andersen, Sonja Benedikte; Slupphaug, Geir; Krokan, Hans Einar; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2011) XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage. Environmental and Molecular Mutagenesis. volum 52 (8).
Vitenskapelig artikkel
Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Research (NAR). volum 39 (19).
Vitenskapelig artikkel
Sousa, Mirta; Steen, Kristian Wollen; Hagen, Lars; Slupphaug, Geir. (2011) Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis. Proteome Science. volum 9.
Vitenskapelig artikkel
Zeitlin, SG; Chapados, BR; Baker, NM; Tai, C; Slupphaug, Geir; Wang, JYJ. (2011) Uracil DNA N-Glycosylase Promotes Assembly of Human Centromere Protein A. PLOS ONE. volum 6 (3).
Vitenskapelig artikkel
Bergstrøm, Bjarte Aune; Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit Walbye. (2010) Identification of a Novel in Vivo Virus-targeted Phosphorylation Site in Interferon Regulatory Factor-3 (IRF3). Journal of Biological Chemistry. volum 285 (32).
Vitenskapelig artikkel
Felberg, Hanne Solvang; Hagen, Lars; Slupphaug, Geir; Batista, Irineu; Nunes, Maria Leonora; Olsen, Ragnar Ludvig; Martinez, iciar. (2010) Partial characterisation of gelatinolytic activities in herring (Clupea harengus) and sardine (Sardina pilchardus) possibly involved in post-mortem autolysis of ventral muscle. Food Chemistry. volum 119 (2).
Vitenskapelig artikkel
Monsen, Vivi A Talstad; Sundheim, Ottar; Aas, Per Arne; Westbye, Marianne Pedersen; Sousa, Mirta; Slupphaug, Geir; Krokan, Hans Einar. (2010) Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3. Nucleic Acids Research (NAR). volum 38 (19).
Vitenskapelig artikkel
Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology. volum 186 (5).
Vitenskapelig artikkel
Knaevelsrud, I; Knaevelsrud, I; Slupphaug, G; Leiros, Ingar; Matsuda, A; Ruoff, P; Ruoff, P; Bjelland, S; Bjelland, S. (2009) Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology. volum 85 (5).
Vitenskapelig artikkel
Knævelsrud, I.; Slupphaug, Geir; Leiros, Ingar; Matsuda, A.; Ruoff, Peter; Bjelland, Svein. (2009) Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology. volum 85 (5).
Vitenskapelig artikkel
Langevin, C; Maidou-Peindara, P; Aas, Per Arne; Jacquot, G; Otterlei, Marit; Slupphaug, Geir; Benichou, S. (2009) Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect. Journal of Virology. volum 83 (19).
Vitenskapelig artikkel
Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Liabakk, Nina-Beate; Sundheim, Ottar; Diaz, Javier Pena; Otterlei, Marit; Hørning, Ole; Jensen, Ole N; Krokan, Hans Einar; Slupphaug, Geir. (2008) Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO Journal. volum 27 (1).
Vitenskapelig artikkel
Sundheim, Ottar; Talstad, Vivi A; Vågbø, Cathrine Broberg; Slupphaug, Geir; Krokan, Hans Einar. (2008) AlkB demethylases flip out in different ways. DNA Repair. volum 7 (11).
Vitenskapelig artikkel
Visnes, Torkild; Akbari, Mansour; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2008) The rate of base excision repair of uracil is controlled by the initiating glycosylase. DNA Repair. volum 7 (11).
Vitenskapelig artikkel
Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate; Slupphaug, Geir; Otterlei, Marit; Krokan, Hans Einar. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry. volum 238 (36).
Vitenskapelig artikkel
Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) Uracil in DNA - General mutagen, but normal intermediate in acquired immunity. DNA Repair.
Vitenskapelig artikkel
Lu, CC; Huang, HT; Wang, JT; Slupphaug, Geir; Li, TK; Wu, MC; Chen, YC; Lee, CP; Chen, MR. (2007) Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication. Journal of Virology. volum 81.
Vitenskapelig artikkel
Parsons, Jason L.; Kavli, Bodil Merete; Slupphaug, Geir; Dianov, Grigory L.. (2007) NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break. Biochemistry. volum 46 (13).
Vitenskapelig artikkel
Pettersen, Henrik P Sahlin; Sundheim, Ottar; Gilljam, Karin Margaretha; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2007) Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms. Nucleic Acids Research (NAR). volum 35 (12).
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2006) Preface. DNA Repair.
Vitenskapelig artikkel
Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Mittelstedt, L.Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO Journal. volum 25.
Vitenskapelig artikkel
Andersen, Sonja Benedikte; Ericsson, Maria Elisabeth Madelene; Dai, HY; Diaz, Javier Pena; Slupphaug, Geir; Nilsen, H; Aarset, H; Krokan, Hans Einar. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair. volum 4 (12).
Vitenskapelig artikkel
Kavli, Bodil Merete; Andersen, Sonja Benedikte; Otterlei, Marit; Liabakk, Nina-Beate; Imai, K; Fischer, A; Durandy, A; Krokan, Hans Einar; Slupphaug, Geir. (2005) B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Journal of Experimental Medicine (JEM). volum 201.
Vitenskapelig artikkel
Zeitlin, SG; Patel, S; Kavli, Bodil Merete; Slupphaug, Geir. (2005) Xenopus CENP - A assembly into chromatin requires base excision repair proteins. DNA Repair. volum 4.
Vitenskapelig artikkel
Andersen, S; Ericsson, M; DAI, H; Peña-Diaz, J; Slupphaug, G; Nilsen, Hilde; Aarset, H; Krokan, HE. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair. volum 4 (12).
Vitenskapelig artikkel
Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Aas, Per Arne; Kavli, Bodil; Liabakk, Nina-Beate; Hagen, Lars; Imai, K; Durandy, A; Slupphaug, Geir; Krokan, Hans Einar. (2004) Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells. Nucleic Acids Research (NAR). volum 32.
Vitenskapelig artikkel
Diaz, Javier Pena; Akbari, Mansour; Sundheim, Ottar; Farez-Vidal, ME; Andersen, S; Sneve, R; Gonzalez-Pacanowska, D; Krokan, Hans Einar; Slupphaug, Geir. (2004) Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair. Journal of Molecular Biology (JMB). volum 342.
Vitenskapelig artikkel
Imai, K; Slupphaug, Geir; Lee, W-I; Revy, P; Nonoyama, S; Catalan, N; Yel, L; Forveille, M; Kavli, Bodil; Krokan, Hans Einar; Ochs, H.D; Fischer, A; Durandy, A. (2003) Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch. Nature Immunology. volum 4.
Vitenskapelig artikkel
Slupphaug, Geir; Kavli, Bodil; Krokan, Hans Einar. (2003) Interacting pathways that prevent and repair oxidative DNA damage. Mutation Research (DNA Repair). volum 531.
Vitenskapelig artikkel
Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen; Krokan, Hans Einar. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature. volum 421.
Vitenskapelig artikkel
Johansen, Tor Arne; Petersen, Idar; Slupphaug, Geir. (2002) Explicit sub-optimal linear quadratic regulation with state and input constraints. Automatica. volum 38.
Vitenskapelig artikkel
Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Skorpen, Frank; Aas, Per Arne; Hagen, Lars; Krokan, Hans Einar; Slupphaug, Geir. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry. volum 18.
Vitenskapelig artikkel
Krokan, Hans Einar; Drabløs, Finn; Slupphaug, Geir. (2002) Uracil in DNA, occurrence, consequences and repair. Oncogene. volum 21.
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2002) Damage and repair of DNA in mammalian cells-emphasis on oxidative damage. Proceedings from International Symposium "Natural Ionising Radiation and Health". Det Norske Videnskaps-Akademi : proceedings.
Vitenskapelig artikkel
Cappelli, E.; Hazra, T.; Hill, J.; Slupphaug, Geir; Bobliolo, M.; Frosina, G.. (2001) Rates of base excision repair are not solely dependent on levels of initiating enzymes. Carcinogenesis. volum 22.
Vitenskapelig artikkel
Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Skjelbred, Camilla Furu; Akbari, Mansour; Aas, Per Arne; Slupphaug, Geir. (2001) Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology. volum 68.
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (2001) Efficient Optimal Prioritized Infeasibility Handling in Model Predictive Control - A Parametric Preemptive Multi-objective Linear Programming Approach. Journal of Optimization Theory and Applications.
Vitenskapelig artikkel
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne; Foss, Bjarne Anton. (2001) Linear MPC with Optimal Prioritized Infeasibility Handling: Application, Computational Issues and Stability. Automatica. volum 37.
Vitenskapelig artikkel
Johansen, Tor Arne; Slupphaug, Geir. (2000) Comment on "Stability issues on Takagi-Sugeno fuzzy model - parametric approach". IEEE transactions on fuzzy systems. volum 8.
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, H.; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair in mammalian cells. FEBS Letters.
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, Hilde; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters.
Vitenskapelig artikkel
Nilsen, Hilde; Rosewell, I.; Robins, P.; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Krokan, Hans Einar; Lindahl, T.; Barnes, D.E.. (2000) ) Ung-deficient mice reveal a primary role of the uracil-DNA glycosylase enzyme during DNA replication. Molecular Cell.
Vitenskapelig artikkel
Nilsen, Hilde; Rosewell, Ian; Robins, Peter; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Daly, Graham; Krokan, Hans Einar; Lindahl, Tomas; Barnes, Deborah E.. (2000) URACIL-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication. Molecular Cell. volum 5.
Vitenskapelig artikkel
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR).
Vitenskapelig artikkel
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR).
Vitenskapelig artikkel
Parikh, S; Walcher, G; Jones, G.D; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.M; Tainer, J.A. (2000) Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America.
Vitenskapelig artikkel
Parikh, Sudip S.; Walcher, Gunter; Jones, Garry D.; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.Michael; Tainer, John A.. (2000) Uracil-DNA glycosylase-DNA substrate and product structures:Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America. volum 97.
Vitenskapelig artikkel
Slupphaug, Geir; Foss, Bjarne Anton. (2000) Nonlinear robust constrained control of partially uncontrollable and open-loop unstable systems. Journal of Process Control. volum 10.
Vitenskapelig artikkel
Slupphaug, Geir; Imsland, Lars Struen; Foss, Bjarne Anton. (2000) Uncertainty modelling and robust output feedback control of nonlinear discrete systems: a mathematical programming approach. International Journal of Robust and Nonlinear Control. volum 10.
Vitenskapelig artikkel
Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bhariti, Sangeeta; Steinsbekk, Kristin; Nilsen, Hilde; Skjelbred, Camilla; Kavli, Bodil; Standal, Rune; Slupphaug, Geir. (1999) Human uracil-DNA glycosylase. NATO Advances Study Institute series. Series A, Life sciences. volum 302.
Vitenskapelig artikkel
Otterlei, Marit; Warbrick, Emma; Nagelhus, Toril; Haug, Terje; Slupphaug, Geir; Akbari, Mansour; Aas, Per Arne; Steinsbekk, Kristin; Bakke, Oddmund; Krokan, Hans Einar. (1999) Post-replicative base excision repair in replication foci. EMBO Journal. volum 18 (13).
Vitenskapelig artikkel
Slupphaug, Geir; Foss, Bjarne Anton. (1999) Constrained quadratic stabilization of discrete-time uncertain non-linear multi-model systems using piecewise affine state-feedback. International Journal of Control. volum 72 (7/8).
Vitenskapelig artikkel
Bharati, S.; Krokan, Hans Einar; Kristiansen, L; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites. Nucleic Acids Research (NAR).
Vitenskapelig artikkel
Krokan, Hans Einar; Parikh, S.S.; Slupphaug, Geir; Bharati, S; Trainer, J.A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO Journal. volum 1998.
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (1998) DNA-reparasjonsenzymer og deres gener. Tidsskrift for Den norske legeforening. volum 118.
Vitenskapelig artikkel
Otterlei, Marit; Haug, T.; Nagelhus, T.A; Slupphaug, Geir; Lindmo, T.; Krokan, Hans Einar. (1998) Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively. Nucleic Acids Research (NAR). volum 26 (20).
Vitenskapelig artikkel
Parikh, S. Sudip; Mol, Clifford D.; Slupphaug, Geir; Bharati, Sangeta; Krokan, Hans Einar; Yainer, John A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase. EMBO Journal. volum 17.
Vitenskapelig artikkel
Krokan, Hans Einar; Standal, Rune; Slupphaug, Geir. (1997) DNA glycosylase in the base excision repair of DNA. Biochemical Journal. volum 325.
Vitenskapelig artikkel
Bouhamdan, M; Benichou, S.; Rey, F.; Navarro, J.M.; Agostini, I.; Spire, B.; Camanis, G.; Slupphaug, Geir; Vigne, R; Benarous, R; Sire, J.. (1996) Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme. Journal of Virology.
Vitenskapelig artikkel
Dizdaroglu, M.; Karakaya, A.; Jaruga, P.; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR).
Vitenskapelig artikkel
Dizdaroglu, Miral; Karakaya, Asuman; Jaruga, Pawel; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR). volum 24 (3).
Vitenskapelig artikkel
Kavli, B.; Slupphaug, Geir; Mol, C.D.; Arvai, A.S.; Petersen, S.B.; Tainer, J.A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal.
Vitenskapelig artikkel
Kavli, Bodil; Slupphaug, Geir; Mol, Clifford D.; Arvai, Andrew S.; Petersen, Steffen B.; Tainer, John A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal. volum 15 (13).
Vitenskapelig artikkel
Nagelhus, T.; Slupphaug, Geir; Krokan, Hans Einar; Lindmo, T.. (1996) Fading correction for fluorescence quantitation in confocal microscopy. Cytometry.
Vitenskapelig artikkel
Slupphaug, Geir; Kavli, B.; Mol, C.D.; Arvai, A.; Krokan, Hans Einar; Tainer, J.A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature.
Vitenskapelig artikkel
Slupphaug, Geir; Mol, Clifford D.; Kavli, Bodil; Arvai, Andrew S.; Krokan, Hans Einar; Tainer, John A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature. volum 384 (7. Nove).
Vitenskapelig artikkel
Slupphaug, Geir; Eftedal, Ingrid; Kavli, Bodil; Bharati, Sangeeta; Helle, Nils M; Haug, Terje; Levine, David William; Krokan, Hans Einar. (1995) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry. volum 34.
Vitenskapelig artikkel
Slupphaug, G.; Markussen, F.-H.; Olsen, Lisbeth Charlotte; Aasland, Rein; Aarsæther, Niels; Bakke, O.; Krokan, H. E.; Helland, Dag Emil. (1993) Human Uracil-DNA glycosylase is shared by the nucleus and the mitochondria. Nucleic Acid Res. volum 21.
Vitenskapelig artikkel
Eftedal, Ingrid; Guddal, Per Henrik; Slupphaug, Geir; Volden, Gunnar; Krokan, Hans Einar. (1993) Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase. Nucleic Acids Research (NAR). volum 21 (9).
Vitenskapelig artikkel
Slupphaug, Geir; Alseth, Ingrun; Eftedal, Ingrid; Volden, Gunnar; Krokan, Hans Einar. (1993) Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification. Analytical Biochemistry. volum 211.
Vitenskapelig artikkel
Slupphaug, G.; Olsen, Lisbeth Charlotte; Helland, Dag Emil; Aasland, Rein; Krokan, H. E.. (1991) Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil- DNA glycosylase. Nucleic Acids Research (NAR). volum 19.
Vitenskapelig artikkel
Thangstad, Ole Petter; Iversen, Tor-Henning; Slupphaug, Geir; Bones, Atle M.. (1990) Immunocytochemical localization of myrosinase. Planta.
Vitenskapelig artikkel

Tidsskriftspublikasjoner

Iveland, Tobias S.; Hagen, Lars; Sharma, Animesh; Sousa, Mirta M. L.; Sarno, Antonio; Wollen, Kristian Lied; Liabakk, Nina-Beate; Slupphaug, Geir. (2021) Correction to: HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines (Journal of Translational Medicine, (2020), 18, 1, (159), 10.1186/s12967-020-02318-8). Journal of Translational Medicine. volum 19 (1).
Errata
Zhao, Chun-Mei; Rabben, Hanne-Line; Zhu, Yanping; Olsen, Magnus Kringstad; Wang, Zhiqiang; Hao, Yanpeng; Cai, Xing; Fonseca, Davi de Miranda; Sharma, Animesh; Li, Mingna; Zhihong, Zhang; Slupphaug, Geir; Wang, Timothy Cragin; Chen, Duan. (2018) 390 - A New Treatment for Pancreatic Cancer: Targeting Nervecancer Cell Crosstalk. Gastroenterology. volum 154.
Sammendrag/abstract
Rydning, Siri Lynne; Backe, Paul Hoff; Sousa, Mirta; Iqbal, Zafar; Øye, Ane-Marte; Sheng, Ying; Yang, Mingyi; Lin, Xiaolin; Slupphaug, Geir; Nordenmark, Tonje Haug; Vigeland, Magnus Dehli; Bjørås, Magnar; Tallaksen, Chantal; Selmer, Kaja Kristine. (2017) Corrigendum: Novel UCHL1 mutations reveal new insights into ubiquitin processing. Human Molecular Genetics. volum 26 (6).
Errata
Slupphaug, Geir. (2016) Modulering av cellulær metabolisme bidrar til Melfalan-resistens i myelomaotse. Best Practice Onkologi/Hematologi. volum 24.
Faglig artikkel
Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Abdollahi, Pegah; Vansemb, Esten; Hagen, Lars; Baranowska, Katarzyna Anna; Misund, Kristine; Slupphaug, Geir; Børset, Magne. (2014) PRL-3 Mediates Survival of Primary Myeloma Cells. Blood. volum 124.
Sammendrag/abstract
Krokan, Hans Einar; Kavli, Bodil Merete; Ericsson, Ida; Galashevskaya, Anastasia; Sarno, Antonio; Aas, Per Arne; Vagbo, CB; Pettersen, Henrik P Sahlin; Slupphaug, Geir. (2013) Genomic uracil - potent mutagen but normal intermediate in adaptive immunity. The FEBS Journal. volum 280.
Sammendrag/abstract
Krokan, Hans Einar; Kavli, Bodil Merete; Otterlei, Marit; Akbari, M.; Slupphaug, Geir; Aas, Per Arne. (2010) DNA repair and cancer. European Journal of Cancer. volum 8 (5).
Sammendrag/abstract
Visnes, Torkild; Doseth, Berit; Pettersen, Henrik Sahlin; Hagen, Lars; Sousa, Mirta; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2009) Uracil in DNA and its processing by different DNA glycosylases. Philosophical Transactions of the Royal Society of London. Biological Sciences. volum 364 (1517).
Vitenskapelig oversiktsartikkel/review
Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology. volum 8 (6).
Vitenskapelig oversiktsartikkel/review
Krokan, Hans Einar; Kavli, Bodil Merete; Akbari, Mansour; Visnes, Torkild; Pettersen, Henrik P Sahlin; Sundheim, Ottar; Hagen, Lars; Otterlei, Marit; Gilljam, Karin Margaretha; Slupphaug, Geir. (2007) Repair og uracil in DNA by UNG2 and SMUG1 - an update. DNA Repair.
Sammendrag/abstract
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA - From molecular biology to phenotype - Preface. DNA Repair. volum 6.
Leder
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA- from molecular biology to phenotype. DNA Repair. volum 6 (4).
Sammendrag/abstract
Sousa, Mirta; Krokan, Hans Einar; Slupphaug, Geir. (2007) DNA-uracil and human pathology. Molecular Aspects of Medicine. volum 28.
Vitenskapelig oversiktsartikkel/review
Hagen, Lars; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2006) Genomic uracil and human disease. Experimental Cell Research. volum 312.
Vitenskapelig oversiktsartikkel/review
Krokan, Hans Einar; Akbari, Mansour; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Ericsson, Madelene; Aarset, Harald; Andersen, Sonja Benedikte; Slupphaug, Geir. (2006) Base excision repair proteins in cancer prevention and acquired immune responses. The FEBS Journal. volum 273.
Sammendrag/abstract
Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair. volum 3 (11).
Vitenskapelig oversiktsartikkel/review
Krokan, Hans Einar; Slupphaug, Geir. (2004) Novel aspects of macromolecular repair and relationship to human disease. Journal of Molecular Medicine. volum 82.
Vitenskapelig oversiktsartikkel/review

Bøker

Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil - Evolution, Biology, Immunology and Disease. World Scientific. 2018. ISBN 978-981-3233-49-2.
Fagbok
Iversen, Tor-Henning; Bones, Atle M.; Slupphaug, Geir. (1993) Bioteknologi - 2 timers valgfag. Gyldendal Akademisk. 1993.
Fagbok

Del av bok/rapport

Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2020) Genomic Uracil in Biology, Immunity and Cancer. DNA Damage, DNA Repair and Disease: Volume 1.
Vitenskapelig kapittel/artikkel
Kavli, Bodil Merete; Slupphaug, Geir. (2018) Genomic Uracil and Immunity. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Sarno, Antonio; Slupphaug, Geir. (2018) Enzymology of Genomic Uracil Repair. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) DNA Repair is Integrated with Many Cellular Processes. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) Viral Uracil - Uracil DNA glycosylases and dUTPases. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir; Drabløs, Finn. (2018) The Earth, Life and Genomic Uracil. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2018) Routes to Uracil in DNA. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil – Valuable Tool in Molecular Biology but Inherent Problem in Sequencing of Ancient DNA. Genomic Uracil - Evolution, Biology, Immunology and Disease.
Faglig kapittel
Krokan, Hans Einar; Slupphaug, Geir; Kavli, Bodil Merete. (2017) Genomic Uracil-Dangers and Benefits in processing. The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design.
Vitenskapelig kapittel/artikkel
Krokan, Hans Einar; Standal, Rune; Bharati, Sangeeta; Otterlei, Marit; Haug, Terje; Slupphaug, Geir; Skorpen, Frank. (1997) Uracil in DNA and the family of concerved uracil DNA glycosylases. Base excision repair on DNA damage.
Vitenskapelig kapittel/artikkel

Rapport

Nygård, M; Nilsen, M; Remseth, V; Slupphaug, Geir; Krokan, Hans Einar. (2002) Uttrykk av det membran-modifiserende enzymet UDPDG i E.coli som funksjon av dyrkningsbetingelser og induksjon av DNA-skader. 2002.
Hovedfagsoppgave
Grøsvik, K; Slupphaug, Geir; Krokan, Hans Einar. (2002) "Characterisation of uracil-exising enzyme activities in organ extracts from UNG knockout and wild-type mice.". 2002.
Hovedfagsoppgave
Imsland, Lars Struen; Slupphaug, Geir; Foss, Bjarne Anton. (2000) Robust output feedback control for constrained discrete-time nonlinear systems using observer-based controllers. 2000.
Rapport
Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (1999) Efficient optimal prioritized infeasibility handling in model predictive control - a parametric preemptive multi-objective linear programming approach. 1999.
Rapport
Slupphaug, Geir. (1998) On robust constrained nonlinear control and hybrid control : BMI and MPC based state-feedback schemes. 1998. ISBN 82-471-0295-1. ITK-rapport & 1998:13-W.
Doktorgradsavhandling
Slupphaug, Geir; Foss, Bjarne Anton. (1996) Model predictive control for a class of hybrid systems. 1996. Rapport (96-46).
Rapport
Slupphaug, Geir. (1995) A brief introduction to some logics, formal languages and Petri net theory. 1995. Rapport (95-45-W).
Rapport
Slupphaug, Geir. (1995) A note on hybrid systems emphasizing approaches in the control community. 1995. Rapport (95-46-W).
Rapport
Slupphaug, Geir; Halvorsen, Ivar. (1995) Forprosjekt: Regulering og overvåking av komplekse industrianlegg. 1995. Rapport (95-29-P).
Rapport

Undervisning

Emner

Formidling

2022

Vitenskapelig foredrag

Eldin, Patrick; Vågbø, Cathrine Broberg; Salinas, Sara; Hagiwara, Masatoshi; Slupphaug, Geir; Briant, Laurence. (2022) Le virus Zika reprogramme l'epitranscriptome des ARNt de l'hote pour l'adapter a son biais des codons et faciliter sa traduction. XXIVème Journées Francophones de Virologie . Societe Francaise de Virologie; Strasbourg. 2022-04-11 - 2022-04-12.
Vitenskapelig foredrag

Slupphaug, Geir; Dikic, Aida; Berg, Sigrid Karlsen; Sharma, Animesh; Hagen, Lars; Vågbø, Cathrine Broberg. (2022) Enhanced protein translation fidelity – a novel target in multiple myeloma treatment?. 8th International Caparica Conference on Analytical Proteomics 2022 . Proteomass Scientific Society; Carparica, Portugal. 2022-07-18 - 2022-07-21.

2019

Poster

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Rokstad, Anne Mari A.; Strand, Berit Løkensgard. (2019) Elucidating host responses towards alginate microspheres using proteomics. Scandinavian Society for Biomaterials 2019 Conference . Scandinavian Society for Biomaterials; Kirkkonummi. 2019-06-12 - 2019-06-14.
Faglig foredrag

Slupphaug, Geir. (2019) Experiences from sabbatical at Berkeley 2019 – scientific and beyond. IKOM onsdagsforedrag . Institutt for klinisk og molekylær medisin (IKOM); NTNU. 2019-11-13 - 2019-11-13.
Vitenskapelig foredrag

Slupphaug, Geir. (2019) Selective removal of aberrant mRNA methylation may counteract “epitranscriptome confusion”. 18th annual Workshop on Structural Biology of DNA Repair (SBDR), Marshall, California . SBDR Executive Commitee; Marshall, CA. 2019-05-05 - 2019-05-09.

2018

Poster

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari. (2018) Identification of adsorbing human plasma proteins on alginate gel beads. BRG Capsule workshop 2018 ; Trondheim. 2018-09-17 - 2018-09-21.
Poster

Coron, Abba Elizabeth; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Strand, Berit Løkensgard; Rokstad, Anne Mari. (2018) Identification of adsorbing human plasma proteins on alginate gel beads. Nordic Proteomics Conference ; Bergen. 2018-04-18 - 2018-04-20.
Faglig foredrag

Slupphaug, Geir. (2018) Endringer i genomet kontra endringer i proteomet- Hvordan kan proteomanalyser komplementere genetiske analyser?. Seminarserie-medisinsk Genetikk, St Olavs Hospital . St Olavs Hospital; Trondheim. 2018-10-24.
Vitenskapelig foredrag

Slupphaug, Geir. (2018) Selective removal of aberrantly methylated mRNA bases may avoid “epitranscriptome confusion”. Onsdagsforedrag IKOM . IKOM, NTNU; Trondheim. 2018-11-28.
Poster

Slupphaug, Geir; Wollen Steen, Kristian; Rabe, Renana; Hagen, Lars; Aas, Per Arne; Sharma, Animesh; Vuk, Palibrk; Bjørås, Magnar; Mosammaparast, Nima; Fonseca, Davi de Miranda; Vågbø, Cathrine Broberg. (2018) A role of ASCC3 in the quality control of methylated mRNA. EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice . EMBO; Capri. 2018-10-14 - 2018-10-17.
Poster

Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Slupphaug, Geir. (2018) DNA and RNA modification profiling using liquid chromatography – mass spectrometry. EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice . EMBO; Capri. 2018-10-14 - 2018-10-17.
Poster

Yang, Rui; Elsaadi, Samah; Misund, Kristine; Slupphaug, Geir; Menu, Eline; Hay, Carl; Cooper, Zac; Vanderkerken, Karin; Børset, Magne; Sponaas, Anne-Marit. (2018) Role of ectoenzymes CD39 and CD73 in the immune response to multiple myeloma. Annual Meeting of the American Association for Cancer Research . American Association for Cancer Research; Chicago. 2018-04-14 - 2018-04-18.

2017

Poster

Gederaas, Odrun Arna; Sharma, Animesh; Bogoeva, Vanya; Mbarak, Saide; Kanamazina, Yusuf; Sporsheim, Bjørnar; Høgset, Anders; Slupphaug, Geir; Hagen, Lars. (2017) The proteome of endosomes after Bleomycine-mediated photochemical internalization on rat bladder cancer cells. 16th International Photodynamic Association World Congress . International Photodynamic Association; Coimbra. 2017-06-08 - 2017-06-13.

2016

Poster

Aachmann, Finn L.; Buchinger, Edith; Slupphaug, Geir. (2016) Interaction studies of UNG2 with its DNA replication fork partners. Euromar 2016 ; Aarhus. 2016-07-03.
Vitenskapelig foredrag

Krokan, Hans Einar; Kavli, Bodil Merete; Pettersen, Henrik Sahlin; Sætrom, Pål; Galashevskaya, Anastasia; Sarno, Antonio; Aas, Per Arne; Doseth, Berit; Slupphaug, Geir. (2016) Genomic Uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan ; Matsue. 2016-11-13 - 2016-11-17.
Vitenskapelig foredrag

Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2016) DNA Repair in diagnosis and therapy of cancer - opportunities and problems. 1st International NTNU Symposium on Clinical Biomarkers of Cancer . NTNU; Trondheim. 2016-06-16 - 2016-06-17.
Vitenskapelig foredrag

Krokan, Hans Einar; Pettersen, Henrik Sahlin; Mjelle, Robin; Hegre, Siv Anita; Sætrom, Pål; Drabløs, Finn Sverre; Sarno, Antonio; Galashevskaya, Anastasia; Aas, Per Arne; Liabakk, Nina-Beate; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete. (2016) REGULATION OF BASE EXCISION REPAIR – CANONICAL AND NON-CANONICAL PROCESSING OF GENOMIC URACIL. 10th International Multiconference on Bioinformatics of Genome Regulation and Structure\Systems Biology . Russian Academy of Sciences, Siberian branch; Akademorodok, Novosibirsk. 2016-08-29 - 2016-09-03.
Faglig foredrag

Krokan, Hans Einar; Slupphaug, Geir; Sætrom, Pål; Sarno, Antonio; Galashevskaya, Anastasia; Lundbæk, Marie Benner; Aas, Per Arne; Krokan, Ruth Haaland; Liabakk, Nina-Beate; Pettersen, Henrik Sahlin; Sousa, Mirta; Doseth, Berit; Kavli, Bodil Merete. (2016) Genomic uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. Eurotox 2016 . Turkish Society of Toxicology.; Sivilla. 2016-09-04.
Poster

Sharma, Animesh; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Fonseca, Davi de Miranda; Slupphaug, Geir. (2016) PROMEC: Services within Proteomics and DNA/RNA-modomics. Seminar for staff at the future Faculty of Medicine and Health Sciences . NTNU - Faculty of Medicine; Scandic Lerkendal Hotel, Trondheim. 2016-11-10 - 2016-11-11.
Vitenskapelig foredrag

Slupphaug, Geir; Steen, Kristian Wollen; Hagen, Lars; Aas, Per Arne; Sharma, Animesh; Vågbø, Cathrine Broberg; Palibrk, Vuk; Bjørås, Magnar; Fonseca, Davi de Miranda. (2016) MMS-induced modifications in mRNA and potential roles of ASCC3/ALKBH3. The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan ; Matsue. 2016-11-13 - 2016-11-17.

2015

Poster

Buchinger, Edith; Rabe, Renana; Wiik, Siv Åshild; Slupphaug, Geir; Aachmann, Finn Lillelund. (2015) Functional impact of intrinsically disordered N-terminus on uracil-DNA glycosylase UNG2. Gordon Research Conference Computational Aspects - Biomolecular NMR . Gordon Research Conference; Lucca (Barga). 2015-06-06 - 2015-06-12.
Poster

Sharma, Animesh; Steven, Lewis; Dahiya, Gurvinder; Slupphaug, Geir. (2015) MS Data Analysis with a Touch of Spark. EUPA2015 . European Proteomics Association; Milan. 2015-06-23 - 2015-06-28.
Vitenskapelig foredrag

Slupphaug, Geir. (2015) Novel aspects of genomic uracil induction and processing. Tomas Lindahl conference on DNA repair ; Oslo. 2015-06-17 - 2015-06-21.
Faglig foredrag

Slupphaug, Geir. (2015) PROMEC Core Facility - Services and ongoing activities. NBS seminar ; Åre. 2015-03-03 - 2015-03-04.

2014

Poster

Gebriel, Mohammed; Sousa, Mirta; Slupphaug, Geir. (2014) Global Proteomic monitoring of Phosphoproteome dynamics during rotenone-induced apoptosis in HeLa cells. NBS Contact Meeting 2014 . Norwegian Biochemical Society; Røros. 2014-01-23 - 2014-01-26.
Poster

Gebriel, Mohammed; Zatula, Alexey; Sousa, Mirta; Hagen, Lars; Slupphaug, Geir. (2014) From tissue to protein networks in (a bit more than) two hours: an ultrafast and a straightforward single-run LC-MS/MS approach for comprehensive proteome analyses. NBS Contact Meeting 2014 . Norwegian Biochemical Society; Røros. 2014-01-23 - 2014-01-26.
Poster

Macur, Katarzyna; Hagen, Lars; Ciesielski, Tomasz Maciej; Konieczna, Lucyna; Skokowski, Jaroslaw; Jenssen, Bjørn Munro; Slupphaug, Geir; Baczek, Tomasz. (2014) Optimization of workflow for targeted MS-based proteomic quantification of osteopontin in healthy and cancerous human breast tissues. 20th International Mass Spectrometry Conference ; Geneva. 2014-08-24 - 2014-08-29.
Poster

Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Abdollahi, Pegah; Vansemb, Esten; Hagen, Lars; Baranowska, Katarzyna Anna; Misund, Kristine; Slupphaug, Geir; Børset, Magne. (2014) PRL-3 Mediates Survival of Primary Myeloma Cells. American Society of Hematology Annual Meeting . American Society of Hematology; San Francisco. 2014-12-06 - 2014-12-09.
Vitenskapelig foredrag

Slupphaug, Geir. (2014) Novel mechanisms contributing to acquired Melphalan resistance in Multiple Myeloma. Torsdahsforedrag, KG Jebsen center for Myeloma Research ; 2014-04-24 - 2014-04-24.
Faglig foredrag

Slupphaug, Geir. (2014) PROMEC core facilityWhat can we offer?One example of quantitative protein profiling to identify factors underlying Melphalan resistance in multiple myeloma. Onsdagsforedrag, Institutt for Kreftforskning og Molekylærmedisin ; 2014-04-30 - 2014-04-30.
Poster

Zatula, Alexey; Demirovic, Aida; Sharma, Animesh; Sousa, Mirta; Sundan, Anders; Slupphaug, Geir. (2014) Biomarker discovery and subtype classification within Multiple Myeloma by Super-SILAC. 2014 Nordic Proteomics Conference ; Turku. 2014-03-11 - 2014-03-13.

2013

Poster

Macur, Katarzyna; Hagen, Lars; Ciesielski, Tomasz Maciej; Konieczna, Lucyna; Skokowski, Jaroslaw; Jensen, Bjørn Munro; Slupphaug, Geir; Baczek, Tomasz. (2013) Targeted MS-based proteomic quantitation of osteopontin in healthy and cancerous human breast tissues. 7th Polish-German Symposium on Pharmaceutical Sciences Interdisciplinary research for pharmacy ; Gdansk. 2013-05-24 - 2013-05-25.
Vitenskapelig foredrag

Sousa, Mirta; Slupphaug, Geir. (2013) Biomarker discovery in multiple myeloma by targeted absolute quantitative proteomics. Trent Northen Group Meeting . Pr. Trent Northen - Lawrence Berkeley National Laboratory; Lawrence Berkeley National Laboratory, Berkeley. 2013-03-05 - 2013-03-05.
Vitenskapelig foredrag

Sousa, Mirta; Slupphaug, Geir. (2013) Targeted Quantitation of Proteins by Mass Spectrometry. Monday Meeting - IKM . IKM - NTNU; 2013-11-25 - 2013-11-25.

2012

Poster

Andersen, Martin Vejle; Doseth, Berit; Hem, Cecilie Anne Dahl; Brembu, Tore; Winge, Per; Slupphaug, Geir; Bones, Atle M.. (2012) Purification and characterisation of an unusual DNA glycosylase in diatoms. 22nd International Diatom Symposium . International Diatom Society; Gent. 2012-08-26 - 2012-08-31.
Poster

Andersen, Martin Vejle; Doseth, Berit; Hem, Cecilie Anne Dahl; Brembu, Tore; Winge, Per; Slupphaug, Geir; Bones, Atle M.. (2012) Purification and characterisation of an unusual DNA glycosylase in diatoms. 3rd Erling Seeberg Symposium on DNA Repair . IKM, NTNU; Trondheim. 2012-06-19 - 2012-06-24.
Poster

Iveland, Tobias Solli; Steen, Kristian Wollen; Hagen, Lars; Slupphaug, Geir. (2012) Ubiquitin independent proteosomal degradation of Uracil DNA Glycosylase 2. 3rd Erling Seeberg Symposium ; 2012-06-19 - 2012-06-24.
Vitenskapelig foredrag

Slupphaug, Geir. (2012) Proteomikk-kjernefasilitet ved NTNU/HMNHva kan vi tilby av analyser?. Fredagsforedrag S ; St Olavs HospitalTrondheim. 2012-05-25.
Vitenskapelig foredrag

Slupphaug, Geir. (2012) The FUGE Proteomics node, NTNU. Instituttdag, IKM ; 2012-03-03 - 2012-03-03.

2011

Poster

Baglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda; Zub, Kamila; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Cancer Proteomics 2011, European Molecular Biology Organization . University of Dublin; The Burlington Hotel, Dublin. 2011-06-20 - 2011-06-23.
Poster

Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. 4th EU-USA conference on DNA base damage and repair . UiO; Holmenkollen Park Hotell. 2011-05-18 - 2011-05-22.
Poster

Sousa, Mirta; Zub, Kamila; Aas, Per Arne; Tian, Erming; Liabakk, Nina-Beate; Young, Clifford; Jensen, Ole Nørregaard; Slupphaug, Geir. (2011) Switch in ATM/ATR expression and up-regulation of NHEJ proteins contribute to acquired melphalan resistance in RPMI8226 myeloma cells. 2nd nordic proteomics symposium ; Copenhagen. 2011-11-27 - 2011-11-29.
Poster

Sousa, Mirta; Zub, Kamila; Aas, Per Arne; Young, Clifford; Tian, Erming; Jensen, Ole Nørregaard; Slupphaug, Geir. (2011) Proteomics screening identifies AKR1C proteins as potential markers for resistance in melphalan resistant RPMI8226-LR5 myeloma cells. 4th EU-USA conference on DNA base damage and repair ; Oslo. 2011-05-18 - 2011-05-22.

2010

Vitenskapelig foredrag

Gederaas, Odrun Arna; Baglo, Yan; Mittelstedt Leal de Sousa, Mirta; Håvåg, Sissel; Zub, Kamila Anna; Helander, Linda; Årset, Toril; Slupphaug, Geir; Krokan, Hans Einar. (2010) Effects of photodynamic therapy on protein expression in cells. 8th International Symposium on PDT . University of Pavada, Italy; Brixen. 2010-10-06 - 2010-10-10.
Vitenskapelig foredrag

Baglo, Yan; Sousa, Mirta; Hagen, Lars; Helander, Linda; Slupphaug, Geir; Gederaas, Odrun Arna. (2010) proteomic and bioinformatic analysis of photodynamic effects in rat bladder cancer cell associated with hexyl aminolevulinate. the 1st annual BioStruct conference 2010 . BioStruct Tromsø; Jægtvolden, Trøndelag. 2010-08-26 - 2010-08-29.
Vitenskapelig foredrag

Bergstrøm, Bjarte Aune; Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit Walbye. (2010) Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3). The 6th Norwegian Proteomics Conference . NTNU; Trondheim. 2010-12-09 - 2010-12-10.
Vitenskapelig foredrag

Gederaas, Odrun Arna; Baglo, Yan; Årset, Toril; Mittelstedt leal de sousa, Mirta; Håvåg, Sissel; Zub, Kamila anna; Helander, Linda; Slupphaug, Geir; Krokan, Hans Einar. (2010) Effects of photodynamic therapy on protein expression in rat bladder cancer cells. Biokjemisk Vintermøte . NBS; Storefjell. 2010-01-14 - 2010-01-16.
Vitenskapelig foredrag

Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. 6th Norwegian National Proteomics Meeting . NTNU; trondheim. 2010-12-09 - 2010-12-10.
Vitenskapelig foredrag

Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Slupphaug, Geir. (2010) Post translational modifications of the human DNA repair protein uracil DNA glycosylase, UNG2. 6th Norwegian National Proteomics Meeting ; 2010-12-09 - 2010-12-10.
Vitenskapelig foredrag

Helander, Linda; Baglo, Yan; Hagen, Lars; Sousa, Mirta; Slupphaug, Geir; Gederaas, Odrun Arna. (2010) Use of proteomic techniques within photodynamic therapy research. 6th Norwegian National Proteomics Meeting ; 2010-12-09 - 2010-12-10.
Vitenskapelig foredrag

Slupphaug, Geir. (2010) Keynote address. 6th Norwegian National Proteomics meeting ; 2010-12-09 - 2010-12-10.
Vitenskapelig foredrag

Slupphaug, Geir. (2010) Proteomics and Nanomedicine. nanomedicine seminar . NTNU; NTNU. 2010-02-19 - 2010-02-19.
Vitenskapelig foredrag

Sousa, Mirta; Steen, Kristian Wollen; Hagen, Lars; Slupphaug, Geir. (2010) Antibody crosslinking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis. 6th Norwegian National Proteomics Meeting . NTNU; trondheim. 2010-12-09 - 2010-12-10.
Vitenskapelig foredrag

Zub, Kamila; Sousa, Mirta; Aas, Per Arne; Young, Clifford; Tian, Erming; Johansen, Jostein; Hagen, Lars; Jensen, Ole Nørregaard; Slupphaug, Geir. (2010) A proteomics and genomic approach to identify factors associated with melphalan resistance in multiple myeloma cells. 6th Norwegian National Proteomics Meeting . NTNU; trondheim. 2010-12-09 - 2010-12-10.

2009

Vitenskapelig foredrag

Baglo, Yan; Mittelstedt leal de sousa, Mirta; Håvåg, Sissel; Helander, Linda; Slupphaug, Geir; Krokan, Hans Einar; Gederaas, Odrun Arna. (2009) Effects of photodynamic therapy on protein expression in cells. 13 th Congress of European Society for Photobiology . Eureopean Society of Photomedicine; Wroclaw. 2009-09-05 - 2009-09-10.
Vitenskapelig foredrag

Baglo, Yan; Mittelstedt leal de sousa, Mirta; Håvåg, Sissel; Zub, Kamila anna; Helander, Linda; Årset, Toril; Slupphaug, Geir; Krokan, Hans Einar; Gederaas, Odrun Arna. (2009) Effects of photodynamic therapy on protein expression in cells. Norsk Forening for Fotobiologi og Fotomedisin . Statens Strålevern, Østerås, Oslo; Oslo. 2009-11-06 - 2009-11-06.
Vitenskapelig foredrag

Bergstrøm, Bjarte; Nguyen, Thuy Tranh; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit W.. (2009) Exploring phosphorylation of the transcription factor Interferon Regulatory Factor 3 in vivo and in vitro. Contact Meeting NBS ; Røros. 2009-01-22 - 2009-01-25.
Vitenskapelig foredrag

Baglo, Yan; Sousa, Mirta; Håvåg, Sissel; Helander, Linda; Slupphaug, Geir; Krokan, Hans Einar; Gederaas, Odrun Arna. (2009) Effects of photodynamic therapy on protein expression in cells. 13th congress of european society for photobiology and the 2nd conference of the european plataform for photodynamic medicine ; Wroclaw. 2009-09-05 - 2009-09-10.
Vitenskapelig foredrag

Bergstrøm, Bjarte; Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Hagen, Lars; Slupphaug, Geir; Thommesen, Liv; Anthonsen, Marit Walbye. (2009) Exploring phosphorylation of the transcription factor Interferon Regulatory Factor 3 in vivo and in vitro. NBS kontaktmøte 2009 . Norsk Biokjemisk Selskap; Røros. 2009-01-29 - 2009-02-01.
Vitenskapelig foredrag

Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka; Catterall, Tara C; Vågbø, Cathrine Broberg; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. 2nd Erling Seeberg Symposium on DNA Repair . Rikshospitalet-Radiumhospitalet og Universitetet i Oslo; 2009-06-20 - 2009-06-25.
Vitenskapelig foredrag

Krokan, Hans Einar; Visnes, Torkild; Doseth, Berit; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir. (2009) Uracil in DNA and its processing. 3rd US-EU Conference- Repair of Endogenous Genome Damage . E. Dogliotti, H. Krokan, T. Stevnsner, S. Mitra, S.H. Wilson; Moody Gardens Hotel, Galveston, Texas. 2009-02-21 - 2009-02-25.
Populærvitenskapelig foredrag

Slupphaug, Geir. (2009) Molecular mechanisms of host defence. Presentation for the Chinese Embassy . NTNU, DMF; Trondheim. 2009-05-12 - 2009-05-12.
Vitenskapelig foredrag

Slupphaug, Geir. (2009) Nye funn innen DNA-reparasjon hos mennesker. DKNVS foredrag . Det Konglige Norske Videnskabers Selskab; Trondheim. 2009-12-14 - 2009-12-14.
Vitenskapelig foredrag

Slupphaug, Geir. (2009) Proteomic Tools in the discovery of Biomarkers. Lily Seminar "An introduction to Cancer Biomarkers in NSCLC" . Eli Lilly; Stjørdal. 2009-02-11 - 2009-02-11.
Vitenskapelig foredrag

Slupphaug, Geir. (2009) Regulation of Genomic Uracil Processing in Mammalian Cells. 3rd US-EU Conference on Repair of Endogenous Genome Damage, Galveston, Texas . NIH, University of Texas Medical Branch; Galveston, Texas. 2009-02-21 - 2009-02-25.
Vitenskapelig foredrag

Slupphaug, Geir. (2009) Regulation of genomic uracil processing by UNG2. Guest Lecture, Ludwig-Maximillians University, Munich . Center for Integrated Protein Science; Ludwig-Maximillians University, Munich. 2009-03-10 - 2009-03-10.
Vitenskapelig foredrag

Slupphaug, Geir. (2009) Regulation of genomic uracil processing in mammalian cells, multiple levels of control of UNG2. Tuesday Lecture, IKM . IKM, NTNU; Trondheim. 2009-03-17 - 2009-03-17.
Vitenskapelig foredrag

Slupphaug, Geir; Doseth, Berit; Kavli, Bodil Merete; Visnes, Torkild; Hagen, Lars; Torseth, Kathrin; Pettersen, Henrik Sahlin; Akbari, Mansour; Otterlei, Marit; Krokan, Hans Einar. (2009) Genomic uracil processing in mice and men. 2.nd Erling Seeberg symposium on DNA repair ; Ålesund/Geiranger. 2009-06-20 - 2009-06-25.
Poster

Sousa, Mirta; Tian, Erming; Hanssen-Bauer, Audun; Zub, Kamila; Banica, Ana; Slupphaug, Geir. (2009) MBD4 is a candidate protein in development of drug resistance in multiple myeloma. The norwegian biochemical society 45th contact meeting ; Røros. 2009-01-29 - 2009-02-01.
Poster

Zub, Kamila; Sousa, Mirta; Young, Clifford; Tian, Erming; Hagen, Lars; Slupphaug, Geir. (2009) Differential protein expression in melphalan sensitive and resistant multiple myeloma cells revealed by SILAC-based quantitative proteomics. 5th Norwegian National Proteomics meeting ; Bergen. 2009-10-26 - 2009-10-27.
Poster

Zub, Kamila; Sousa, Mirta; Young, Clifford; Tian, Erming; Johansen, Jostein; Hagen, Lars; Jensen, Ole Nørregaard; Slupphaug, Geir. (2009) What a difference melphalan makes! Differential protein expression in melphalan resistant and sensitive multiple myeloma cells using SILAC analysis. Proteomics Europe . Select Biosciences; Barcelona. 2009-11-05 - 2009-11-06.

2008

Vitenskapelig foredrag

Slupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate; Otterlei, Marit; Krokan, Hans Einar. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance ; St. Petersburg. 2008-06-24 - 2008-06-26.
Vitenskapelig foredrag

Slupphaug, Geir. (2008) Post-translational modifications regulating DNA repair. Trondheim Conference on Systems Biology . NTNU; Trondheim. 2008-08-18 - 2008-08-19.
Vitenskapelig foredrag

Slupphaug, Geir. (2008) Proteomic studies in DNA repair. Seminar, Institutt for Bioteknologi, NTNU . Institutt for Bioteknologi, NTNU; Trondheim. 2008-01-16 - 2008-01-16.
Vitenskapelig foredrag

Slupphaug, Geir. (2008) Regulation of uracil-DNA repair by post-translational modification of UNG2. BBB Seminar series, University of Bergen . Institutt for Biomedisin, UiB; Bergen. 2008-10-16 - 2008-10-16.
Vitenskapelig foredrag

Slupphaug, Geir. (2008) The Interactomics of DNA repair. Oppdalsmøte, FUGE Midt-Norge og NBS Trøndelag . FUGE Midt-Norge og NBS Trøndelag; Oppdal. 2008-03-26 - 2008-03-27.
Vitenskapelig foredrag

Slupphaug, Geir. (2008) The never-ending story of UNG. Mandagsforedrag Faggr. for molekylærbiologi IKM . Faggr. for molekylærbiologi IKM; Laboratoriesenteret, NTNU. 2008-12-15 - 2008-12-15.

2007

Populærvitenskapelig foredrag

Slupphaug, Geir. (2007) Administrative støtteprosesser ved DMF - innspill fra vitenskapelige ansatte. Allmøte, DMF . Det Medisinske Fakultet, NTNU; Trondheim. 2007-01-30 - 2007-01-30.
Vitenskapelig foredrag

Slupphaug, Geir. (2007) Cell Cycle Regulated Phosphorylations of Human Uracil-DNA Glycosylase UNG2 Govern Replication-Associated Uracil Removal. Mandagsforedrag, Institutt for kreftforskning og molekylærmedisin . Institutt for kreftforskning og molekylærmedisin; Trondheim. 2007-01-22 - 2007-01-22.
Vitenskapelig foredrag

Slupphaug, Geir. (2007) Cell cycle regulation of Uracil repair. Tirsdagsforedrag, Institutt for kreftforskning og molekylærmedisin . Institutt for kreftforskning og molekylærmedisin; Trondheim. 2007-10-09 - 2007-10-09.
Vitenskapelig foredrag

Slupphaug, Geir. (2007) Proteomics. Instituttdag, Institutt for Kreftforskning og Molekylærmedisin, DMF . Institutt for Kreftforskning og Molekylærmedisin, DMF; Stiklestad. 2007-06-18 - 2007-06-18.
Vitenskapelig foredrag

Slupphaug, Geir. (2007) RNA damage and repair and medical significance. 37th annual meeting of the European environmental society, EEMS . European environmental society, EEMS; Basel. 2007-09-09 - 2007-09-13.

2006

Vitenskapelig foredrag

Slupphaug, Geir. (2006) DNA repair and acquired immunity. Invitert foredrag . Norwegian Society for Immunologi; Rikshospitalet, Oslo. 2006-05-23 - 2006-05-23.
Vitenskapelig foredrag

Slupphaug, Geir. (2006) Forskningsaktiviteter ved IKM, Laboratoriesenteret. Instituttsamling, Inst. for Laboratoriemedisin, NTNU . Inst. for Laboratoriemedisin, NTNU; Bortistu, Oppdal. 2006-03-23 - 2006-03-24.
Vitenskapelig foredrag

Slupphaug, Geir. (2006) Human UNG2 - a uracil DNA glycosylase of many functions. Invitert foredrag, Departement de Maladies Infectieuses, Institut Cochin . Institute Cochin; Paris. 2006-10-06 - 2006-10-06.
Vitenskapelig foredrag

Slupphaug, Geir. (2006) Phosphorylation of UNG2 and potential functional implications. Tirsdagsforedrag . IKM; MTFS, NTNU. 2006-01-10 - 2006-01-10.
Vitenskapelig foredrag

Slupphaug, Geir. (2006) Regulation of Uracil Base Excision Repair by Post-translational modifications. Erling Seeberg Symposium on DNA Repair . UiO, NTNU; Bodø, Henningsvær. 2006-05-28 - 2006-06-02.
Vitenskapelig foredrag

Slupphaug, Geir. (2006) The Proteomics Laboratory at IKM, NTNU. FUGE-seminar . FUGE Midt-Norge; Hell, Stjørdal. 2006-03-28 - 2006-03-28.
Poster

Sousa, Mirta; Sundheim, Ottar; Vågbø, Cathrine Broberg; Talstad, Vivi; Aslaksen, Petter Broby; Slupphaug, Geir. (2006) Post-translational self-hydroxilation of an active site leucine in human ABH3 may protect against generation of damaging oxygen radicals. Erling Seeberg Symposium on DNA Repair ; Bodø og Hennigsvær. 2006-05-28 - 2006-06-02.
Poster

Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Erling Seeberg Symposium on DNA Repair ; 2006-05-28 - 2006-06-02.
Poster

Hagen, Lars; Kavli, Bodil Merete; Sundheim, Ottar; Sousa, Mirta; Otterlei, Marit; Liabakk, Nina-Beate; Torseth, Kathrin; Krokan, Hans Einar; Slupphaug, Geir. (2006) Regulation of uracil base excision repair by post-translational modifications. Erling Seeberg Symposium on DNA Repair ; 2006-05-28 - 2006-06-02.
Poster

Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A; Slupphaug, Geir. (2006) Crystal structure of hABH3 DNA/RNA demethylase reveals a novel active-site leucine oxidation. The Norwegian Biochemical Society 42. Contact Meeting . Norwegian Biochemical Society (NBS); Storefjell, Storefjell Hotell. 2006-01-19 - 2006-01-22.

2005

Poster

Diaz, Javier Pena; Hegre, Siv Anita; Akbari, Mansour; Sousa, Mirta; Sundheim, Ottar; Hanssen-Bauer, Audun; Slupphaug, Geir; Krokan, Hans Einar; Otterlei, Marit. (2005) Recruitment of the chaperone Hsp70 to Base Excision Repair complexes. 2nd EU-US DNA RepairMeeting ; 2005-11-29 - 2005-12-03.
Poster

Kavli, Bodil Merete; Diaz, Javier Pena; Otterlei, Marit; Liabakk, Nina-Beate; Giljam, Karin Margaretha; Krokan, Hans Einar; Hørning, Ole; Jensen, Ole N; Slupphaug, Geir; Hagen, Lars. (2005) The enzymatic activity of human uracil-DNA glycosylase UNG2 is regulated by N-terminal phosphorylation during cell cycle. 2nd EU-US DNA Repair Meeting: Endogeneous Stress, Base excision repair and related processes . Instituto Superiore di Sanita/EMBO; Erice, Sicily. 2005-11-28 - 2005-12-03.
Poster

Nguyen, Thank Thuy Thi; Johnsen, Ingvild Bjellmo; Hagen, Lars; Torseth, Kathrin; Espevik, Terje; Slupphaug, Geir; Anthonsen, Marit Walbye. (2005) Identification of novel proteins associated with a pathogen patten recognition receptor mediating antiviral immune responses. The Norwegian Biochemical Society 41st Contact Meeting . NBS; Tromsø. 2005-01-13 - 2005-01-16.
Vitenskapelig foredrag

Slupphaug, Geir. (2005) Post-translational modifications of hABH3 and UNG2 and their biological implications. 2nd EU-US DNA Repair Meeting. Endogeneous stress, base excision repair and related processes . Instituto Superiore di Sanita, Rome, Italy/ EMBO; Erice, Sicily. 2005-11-28 - 2005-12-03.
Vitenskapelig foredrag

Slupphaug, Geir. (2005) Proteomics and the molecular choreography of mammalian DNA base excision repair. 1st National proteomics meeting . FUGE; Bergen. 2005-05-18.
Vitenskapelig foredrag

Slupphaug, Geir. (2005) Structure of the hABH3 DNA demethylase implicates an oxidized leucine residue in catalysis. 2nd ESF Functional Genomics conference. Satellite meeting - Functional genomics in the Nordic countries . FUGE; Oslo. 2005-09-06 - 2005-09-06.
Poster

Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A; Slupphaug, Geir. (2005) Structure of the hABH3 DNA demethylase implicates an oxidized leucine residue in catalysis. 2nd ESF Functional Genomics and disease ; 2005-09-06.

2004

Poster

Kavli, Bodil; Otterlei, Marit; Liabakk, Nina-Beate; Krokan, Hans Einar; Slupphaug, Geir. (2004) The mutant UNG2-F-25 1S associated with HIGM syndrome is abnormally translocated and degraded, and results in impaired nuclear uracil excision and accumulation of genomic uracil. ASM Conference on DNA Repair and Mutagenesis ; Bermuda. 2004-11-14 - 2004-11-20.
Intervju

Slupphaug, Geir. (2004) Bare late B-mennesker. null [TV]. 2004-12-02.
Intervju

Slupphaug, Geir. (2004) Gen-skrotet som ble til gull. NRK1 Schrødingers Katt [TV]. 2004-01-14.
Vitenskapelig foredrag

Slupphaug, Geir. (2004) Proteomics and the molecular coordination of DNA uracil base excision repair. The 5th Proteome Information Exchange meeting ; MÜnster. 2004-05-09 - 2004-05-12.
Poster

Sundheim, Ottar; Krokan, Hans Einar; Slupphaug, Geir. (2004) Structural anc biochemical analysis of the major groove recognition loop (MGRL). Gordon Conference on Mutagenesis ; Oxford, England. 2004-09-12 - 2004-09-17.
Poster

Sundheim, Ottar; Parikh, Sudip S; Lund, Terje; Krokan, Hans Einar; Slupphaug, Geir; Tainer, John A. (2004) Structural and biochemical analysis of the minor-groove recognition loop (MGRL) motif in UDG. DNA repair and mutagenesis: From molecular structure to biological consequences . American Society for Microbiology; Southampton. 2004-11-14 - 2004-11-20.

2002

Vitenskapelig foredrag

Aas, Per Arne; Otterlei, Marit; Skorpen, Frank; Akbari, Mansour; Slupphaug, Geir; Krokan, Hans Einar. (2002) Repair of alkylated single-stranded DNA and RNA in living cells. 38.Biokjemiske kontaktmøte Functional genomics-the mosaics of life . [Mangler data]; Røros. 2002-01-20.
Poster

Andersen, Sonja; Nilsen, Hilde; Grøsvik, K; Kønig, I; Sneve, R; Slupphaug, Geir; Krokan, Hans Einar. (2002) Uracil-DNA glycosylase knockout mice. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life . [Mangler data]; Røros, Norge. 2002-01-20.
Poster

Andersen, Sonja; Nilsen, Hilde; Grøsvik, K; Kønig, I; Sneve, R; Slupphaug, Geir; Stamp, G; Hrivnak, G; Lindahl, T; Barnes, D.E; Krokan, Hans Einar. (2002) "URACIL-DNAGLYCOSYLASE KNOCKOUT MICE-effects on lifespan and health. Characterisation of uracil removing activities in wild type and Ung deficient mice.". Meeting on DNA repair . [Mangler data]; Warsaw. 2002-09-07.
Poster

Kavli, Bodil; Otterlei, Marit; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in uracil-DNA repair in the nucleus. Mutagenesis and Carcinogenesis, Gordon Research Conference . [Mangler data]; Ventura, California, USA. 2002-03-08.
Poster

Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Otterlei, Marit; Skorpen, Frank; Krokan, Hans Einar; Slupphaug, Geir. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in DNA-uracil repair in the nucleus. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life . [Mangler data]; Quality Hotel Røros. 2002-01-20.
Poster

Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2002) Substrate preference and enzyme kinetics reveal distinct properties of UNG2 and SMUG1 in cellular base-excision repair; hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup. 32nd Annual Meeting of European Environmental Mutagen Society. DNA Damage and Repair Fundamental Aspects and Contribution to Human Disorders . [Mangler data]; Warsaw. Poland. 2002-09-07.
Poster

Pena-Diaz, Javier; Farez-Vidal, M.E; Sundheim, Ottar; Leal-Cortijo, I; Gonzales-Pacanowska, D; Krokan, Hans Einar; Slupphaug, Geir. (2002) Kinetic characterisation of the uracil-DNA glycosylase from the protozoa parasite Trypanosome cruziNorsk biokjemis. 38. Biokjemiske kontaktmøte . [Mangler data]; Røros, Norge. 2002-01-20.
Populærvitenskapelig foredrag

Slupphaug, Geir. (2002) Dypdykk i DNA-molekylet - Hva er nå det for slags liv?. [Mangler data] . Populærvitenskapelig foredrag for medisinerstudenter; Trondheim, Norge. 2002-02-18.

2001

Vitenskapelig foredrag

Imsland, Lars Struen; Slupphaug, Geir; Foss, Bjarne Anton. (2001) Piecewise affine observer-based robust controllers for constrained nonlinear systems. European Control Conference 2001 . [Mangler data]; Porto, Portugal. 2001-09-04.
Vitenskapelig foredrag

Imsland, Lars Struen; Slupphaug, Geir; Foss, Bjarne Anton. (2001) Robust observer-based output feedback for nonlinear discrete-time systems with constraints. NOLCOS 2001 . [Mangler data]; St. Petersburg, Russia. 2001-07-05.
Vitenskapelig foredrag

Slupphaug, Geir. (2001) Functional Genomics and the future. Section for medical Genetics. . [Mangler data]; Trondheim. 2001-04-04.
Vitenskapelig foredrag

Slupphaug, Geir. (2001) Functional implications of the UNG2 regulatory domain in BER and transcription regulation. Workshop DNA repair. . [Mangler data]; Noordwijkerhout, Nederland. 2001-03-02.
Populærvitenskapelig foredrag

Slupphaug, Geir. (2001) Functions of different UDGS in mammalian cells. [Mangler data] . "Tirsdagsmøte" populærvitenskapelig foredrag.; Medisinsk Teknisk Senter. 2001-11-06.
Programdeltagelse

Slupphaug, Geir. (2001) Litt mer avansert enn bananflua. Schrødingers Katt [TV]. 2001-02-02.
Populærvitenskapelig foredrag

Slupphaug, Geir. (2001) Regulering av base-eksisjonsreparasjon. [Mangler data] . "Tirsdagsmøte" populærvitenskapelig foredrag; Medisinsk Teknisk Senter. 2001-02-13.
Poster

Slupphaug, Geir; Skorpen, Frank; Nilsen, H.; Fenstad, M.; Rosello, Ch.; Otterlei, Marit; Aas, P.A.; Krokan, Hans Einar. (2001) Functional implications of the UNG2 regulatory domain in BER and transcription regulation. Workshop DNA repair: Interplay with other cellular processes . [Mangler data]; Noordwijkerhout, The Netherlands, February 25 - March 2, 2001.
Poster

Sundheim, Ottar; Otterlei, Marit; Kavli, Bodil; Skorpen, Frank; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2001) Structure-function analysis of the human uracil-DNA glycosylase hSMUG1. Sixth International School on the Crystallography of Biological Macromolecules. . [Mangler data]; Como, Italy. 2001-05-17.

2000

Vitenskapelig foredrag

Johansen, Tor Arne; Petersen, Idar; Slupphaug, Geir. (2000) Explicit suboptimal constrained LQR. Workshop on systems with time-domain constraints . [Mangler data]; Eindhoven, September 2000.
Vitenskapelig foredrag

Johansen, Tor Arne; Petersen, Idar; Slupphaug, Geir. (2000) On explicit suboptimal LQR with state and input constraints. IEEE Conference on Decision and Control . [Mangler data]; Sydney, 12-15 December 2000.
Populærvitenskapelig foredrag

Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Slupphaug, Geir; Barnes, Deborah; Lindahl, Tomas. (2000) Structure-function aspects of human uracil-DNA glycosylase and its interactions with other proteins. DNA Base Excision Repair Workshop (BER 2000 WORKSHOP) . [Mangler data]; Galveston, Texas, March 10 - 13, 2000.
Populærvitenskapelig foredrag

Nilsen, Hilde; Roswell, Ian; Robins, Peter; Slupphaug, Geir; Steinsbekk, Kristin; Otterlei, Marit; Andersen, Sonja; Lindahl, Tomas; Barnes, Deborah; Krokan, Hans Einar. (2000) Characterisation Of The Major Murine Uracil-DNA Glycosylase And Expression Patterns And Generation of ung/-Knockout Mice. DNA Base Excision Repair Workshop (BER 2000 Workshop) . [Mangler data]; Galveston, Texas, USA March 10 - 13, 2000.
Populærvitenskapelig foredrag

Parikh, Sudip S; Walcher, Gunter; Jones, Garry D; Slupphaug, Geir; Krokan, Hans Einar; Tainer, John A. (2000) UDG-DNA Uncleaved-Substrate Structure is Strained by Coupled Stereoelectronic Effects. DNA Base Excision Repair Workshop (BER 2000 Workshop) . [Mangler data]; Galveston, Texas, USA.
Vitenskapelig foredrag

Slupphaug, Geir. (2000) Frequency Domain Curve Fitting: A Global Approach. IEEE Conference on Decision and Control . [Mangler data]; Sydney, 12-15 December 2000.
Programdeltagelse

Slupphaug, Geir. (2000) Schrødingers katt - Månebarna. null [TV]. null.
Vitenskapelig foredrag

Slupphaug, Geir; Foss, Bjarne Anton. (2000) Multi-model based uncertainty and robust control design. IFAC Symposium ADCHEM . [Mangler data]; Pisa, June 2000.
Vitenskapelig foredrag

Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne; Foss, Bjarne Anton. (2000) Stabilizing linear MPC with efficient prioritized infeasibility handling. IFAC Symposium ADCHEM . [Mangler data]; Pisa, June 2000.

1999

Poster

Barikh, S.S.; Lund, T.; Slupphaug, Geir; Krokan, Hans Einar; Ghazal, P.; Tainer, J.A.. (1999) Structural and biochemical analysis of a cytomegalovirus-human UDG chimera created by functional segment exchange. [Mangler data] . [Mangler data]; 1-7 november 1999.
Poster

Krokan, Hans Einar; Slupphaug, Geir; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank. (1999) Excicion Repar of DNA Damage 1. [Mangler data] . [Mangler data]; 1-7 november 1999.
Vitenskapelig foredrag

Vada, Jostein; Slupphaug, Geir; Foss, Bjarne Anton. (1999) Infeasibility handling in linear MPC subject to prioritized constraints. Preprints of the 14th World Congress of IFAC . [Mangler data]; Beijing, China, July 1999.
Vitenskapelig foredrag

Vada, Jostein; Slupphaug, Geir; Johansen, Tor Arne. (1999) Efficient infeasibility handling in linear MPC subject to prioritized constraints. Proceedings of European Control Conference '99 . [Mangler data]; Karlsruhe, Germany, Aug/Sept 1999.

1998

Vitenskapelig foredrag

Bharati, Sangeeta; Krokan, Hans Einar; Kristiansen, Lena; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1)is processed to two forms one of which is resistant to inhibition by AP-sites. AACR Special Conference in Cancer Research. Endogeneous sources of Mutations. . [Mangler data]; Ft. Myers, Florida.
Populærvitenskapelig foredrag

Slupphaug, Geir. (1998) På kryss og tvers med proteiner. Innledningsforedrag, etterutdanningskurs for bioingeniører . [Mangler data]; Scandic Hotel, Trondheim.
Populærvitenskapelig foredrag

Slupphaug, Geir. (1998) Søkelys på genteknologi. Rotary . [Mangler data]; Trondheim.
Populærvitenskapelig foredrag

Slupphaug, Geir. (1998) Søkelys på gentekologi. Rotary . [Mangler data]; Trondheim.
Vitenskapelig foredrag

Slupphaug, Geir; Foss, Bjarne Anton. (1998) Bilinear matrix inequalities and robust stability of nonlinear multi-model MPC. American Control Conference . [Mangler data]; Philadelphia, USA.
Vitenskapelig foredrag

Slupphaug, Geir; Foss, Bjarne Anton. (1998) Robust stabilization of discrete-time multi-model systems using piecewise affine state-feedback. Dynamics and Control for Process Systems . [Mangler data]; Korfu, Greece.

1997

Vitenskapelig foredrag

Slupphaug, Geir; Foss, Bjarne Anton. (1997) Model predictive control for a class of hybrid systems. European Control Conference . [Mangler data]; Brussel.
Vitenskapelig foredrag

Slupphaug, Geir; Vada, Jostein; Foss, Bjarne Anton.

Språkvelger

Geir Slupphaug

Geir Slupphaug

Om

Proteomics, Genome Dynamics and DNA repair

Kompetanseord

Publikasjoner

2022

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