Markus Rudolf Drexl
Om
Jeg har bakgrunn fra cochleafysiologi og har spesialisert meg på biofysiske (otoakustiske emisjoner, fremkalte potensialer) og psykofysiske (tinnitusmatching, høreterskler) målinger av det indre øret hos pattedyr, inkludert, men ikke begrenset til, mennesker. Jeg har mer enn 20 års erfaring med forskning på en rekke ulike temaer, men det overordnede temaet har alltid vært å få en bedre forståelse av hvordan det indre øret fungerer. Jeg er overbevist om at det å studere ulike organismer og deres spesialisering i forhold til deres individuelle lydlandskap hjelper oss til å forstå bedre hvordan og hvorfor vi mennesker hører (og ikke hører) slik vi gjør: Låveugler og ørkenrotter har lært oss hvordan hørselssystemene våre hører og analyserer romlige lyder, og fugler har hjulpet oss å forstå fordelene med et flerkomponent-mellomøre.
I løpet av det siste tiåret har det vært en økende bekymring for lyd fra tekniske kilder som vindturbiner i det lavfrekvente (mellom ca. 20 og 250 Hz) og infralydområdet (under 20 Hz).
Eksponering for infralyd har blitt beskyldt for å utløse en rekke vage og noen ganger invalidiserende symptomer, som svimmelhet, angst, søvnforstyrrelser og hjertearytmi. Siden lydnivåene noen ganger har vist seg å ligge under høreterskelen i klagernes hjem, har det blitt spekulert i om disse utslippene likevel kan ha negative effekter på menneskers helse. Det betyr at andre sansesystemer med antatt lavere terskel enn hørselssystemet påvirkes. For å kunne gjennomføre en grundig risikovurdering av lavfrekvente utslipp og infralyd er det nødvendig med en bedre forståelse av hvilke sansesystemer som er involvert i prosesseringen.
Jeg er interessert i hvordan det indre øret prosesserer lavfrekvent lyd og infralyd, og hvorfor det forårsaker irritasjon hos en betydelig andel av befolkningen.
Publikasjoner
2021
-
Lattenkamp, Ella Z;
Nagy, Martina;
Drexl, Markus Rudolf;
Vernes, Sonja C;
Knörnschild, Mirjam;
Wiegrebe, Lutz.
(2021)
Hearing sensitivity and amplitude coding in bats are differentially shaped by echolocation calls and social calls.
Proceedings of the Royal Society of London. Biological Sciences
Vitenskapelig artikkel
2020
-
Luecke, Vivian Nancy;
Buchwieser, Laura;
zu Eulenburg, Peter;
Marquart, Torsten;
Drexl, Markus Rudolf.
(2020)
Ocular and cervical vestibular evoked myogenic potentials elicited by air-conducted, low-frequency sound.
Journal of Vestibular Research-Equilibrium & Orientation
Vitenskapelig artikkel
2019
-
Fischl, Matthew J;
Ueberfuhr, Margarete A;
Drexl, Markus Rudolf;
Pagella, Sara;
Sinclair, James;
Alexandrova, Olga.
(2019)
Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift.
Journal of Physiology
Vitenskapelig artikkel
-
Ueberfuhr, Margarete A;
Drexl, Markus Rudolf.
(2019)
Slow oscillatory changes of DPOAE magnitude and phase after exposure to intense low-frequency sounds.
Journal of Neurophysiology
Vitenskapelig artikkel
2018
-
Drexl, Markus Rudolf;
Krause, Eike;
Gürkov, Robert.
(2018)
A Comparison of Distortion Product Otoacoustic Emission Properties in Ménière's Disease Patients and Normal-Hearing Participants.
Ear and Hearing
Vitenskapelig artikkel
2017
-
Jeanson, Lena;
Wiegrebe, Lutz;
Gürkov, Robert;
Krause, Eike;
Drexl, Markus Rudolf.
(2017)
Aftereffects of Intense Low-Frequency Sound on Spontaneous Otoacoustic Emissions: Effect of Frequency and Level.
Journal of the Association for Research in Otolaryngology
Vitenskapelig artikkel
-
Ueberfuhr, Margarete A;
Wiegrebe, Lutz;
Krause, Eike;
Gürkov, Robert;
Drexl, Markus Rudolf.
(2017)
Tinnitus in Normal-Hearing Participants after Exposure to Intense Low-Frequency Sound and in Ménière's Disease Patients.
Frontiers in Neurology
Vitenskapelig artikkel
-
Ueberfuhr, Margarete A;
Braun, Amalia;
Wiegrebe, Lutz;
Grothe, Benedikt;
Drexl, Markus Rudolf.
(2017)
Modulation of auditory percepts by transcutaneous electrical stimulation.
Hearing Research
Vitenskapelig artikkel
2016
-
Drexl, Markus Rudolf;
Wiegrebe, Lutz;
Otto, Larissa;
Marquart, Torsten;
Gürkov, Robert;
Krause, Eike.
(2016)
Low-frequency sound exposure causes reversible long-term changes of cochlear transfer characteristics.
Hearing Research
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Krause, Eike;
Gürkov, Robert;
Wiegrebe, Lutz.
(2016)
Responses of the Human Inner Ear to Low-Frequency Sound.
Advances in Experimental Medicine and Biology
Vitenskapelig artikkel
2015
-
Kugler, Kathrin;
Wiegrebe, Lutz;
Gürkov, Robert;
Krause, Eike;
Drexl, Markus Rudolf.
(2015)
Concurrent Acoustic Activation of the Medial Olivocochlear System Modifies the After-Effects of Intense Low-Frequency Sound on the Human Inner Ear.
Journal of the Association for Research in Otolaryngology
Vitenskapelig artikkel
2014
-
Kugler, Kathrin;
Grothe, Benedikt;
Kössl, Manfred;
Gurkov, Robert;
Krause, Eike;
Drexl, Markus Rudolf.
(2014)
Low-frequency sound affects active micromechanics in the human inner ear.
Royal Society Open Science
Vitenskapelig artikkel
-
Weddell, Thomas D;
Yarin, Yury M;
Drexl, Markus Rudolf;
Russell, Ian J;
Elliott, Stephen J;
Lukashkin, Andrei N.
(2014)
A novel mechanism of cochlear excitation during simultaneous stimulation and pressure relief through the round window.
Journal of the Royal Society Interface
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Ueberfuhr, Margarete A;
Weddell, Thomas D;
Lukashkin, Andrei N;
Wiegrebe, Lutz;
Krause, Eike.
(2014)
Multiple indices of the 'bounce' phenomenon obtained from the same human ears.
Journal of the Association for Research in Otolaryngology
Vitenskapelig artikkel
-
Kantner, Claudia;
Hapflmeier, Alexander;
Drexl, Markus Rudolf;
Gürkov, Robert.
(2014)
The effects of rise/fall time and plateau time on ocular vestibular evoked myogenic potentials.
European Archives of Oto-Rhino-Laryngology
Vitenskapelig artikkel
2013
-
Krause, Eike;
Mayerhofer, Andreas;
Gürkov, Robert;
Drexl, Markus Rudolf;
Braun, Thomas;
Olzowy, Berhard.
(2013)
Effects of acoustic stimuli used for vestibular evoked myogenic potential studies on the cochlear function.
Otology & Neurotology
Vitenskapelig artikkel
2012
-
Drexl, Markus Rudolf;
Gürkov, Robert;
Krause, Eike.
(2012)
Low-frequency modulated quadratic and cubic distortion product otoacoustic emissions in humans.
Hearing Research
Vitenskapelig artikkel
2008
-
Drexl, Markus Rudolf;
Mellado Lagarde, Marcia M;
Zuo, Jian;
Lukashkin, Andrei N;
Russell, Ian.
(2008)
The role of prestin in the generation of electrically evoked otoacoustic emissions in mice.
Journal of Neurophysiology
Vitenskapelig artikkel
-
Mellado Lagarde, Marcia M;
Drexl, Markus Rudolf;
Lukashkin, Andrei N;
Zuo, Jian;
Russell, Ian.
(2008)
Prestin's role in cochlear frequency tuning and transmission of mechanical responses to neural excitation.
Current Biology
Vitenskapelig artikkel
-
Mellado Lagarde, Marcia M;
Drexl, Markus Rudolf;
Lukashkina, Victoria A;
Lukashkin, Andrei N;
Russell, Ian J.
(2008)
Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier.
Nature Neuroscience
Vitenskapelig artikkel
2005
-
Wittekindt, Anna;
Drexl, Markus Rudolf;
Kössl, Manfred.
(2005)
Cochlear sensitivity in the lesser spear-nosed bat, Phyllostomus discolor.
Journal of Comparative Physiology A. Sensory, neural, and behavioral physiology
Vitenskapelig artikkel
2004
-
Drexl, Markus Rudolf;
Kössl, Manfred;
Henke, Julia.
(2004)
Isoflurane increases amplitude and incidence of evoked and spontaneous otoacoustic emissions.
Hearing Research
Vitenskapelig artikkel
2003
-
Russell, Ian;
Drexl, Markus Rudolf;
Foeller, Elisabeth;
Vater, Marianne;
Kössl, Manfred.
(2003)
The development of a single frequency place in the mammalian cochlea: the cochlear resonance in the mustached bat Pteronotus parnellii.
Journal of Neuroscience
Vitenskapelig artikkel
-
Russell, Ian;
Drexl, Markus Rudolf;
Foeller, Elisabeth;
Vater, Marianne;
Kössl, Manfred.
(2003)
Synchronization of a nonlinear oscillator: processing the cf component of the echo-response signal in the cochlea of the mustached bat.
Journal of Neuroscience
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Faulstich, Michael;
von Stebut, Boris;
Radtke-Schuller, Susanne;
Kössl, Manfred.
(2003)
Distortion product otoacoustic emissions and auditory evoked potentials in the hedgehog tenrec, Echinops telfairi.
Journal of the Association for Research in Otolaryngology
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Kössl, Manfred.
(2003)
Sound-evoked efferent effects on cochlear mechanics of the mustached bat.
Hearing Research
Vitenskapelig artikkel
-
Kössl, Manfred;
Foeller, Elisabeth;
Drexl, Markus Rudolf;
Vater, Marianne;
Mora, Emanuel;
Coro, Frank.
(2003)
Postnatal development of cochlear function in the mustached bat, Pteronotus parnellii.
Journal of Neurophysiology
Vitenskapelig artikkel
2002
-
Pibal, Iris;
Drexl, Markus Rudolf;
Kössl, Manfred.
(2002)
Level dependence of optimal stimulus level difference for evoking DPOAEs in the gerbil.
Hearing Research
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Lattenkamp, Ella Z;
Nagy, Martina;
Drexl, Markus Rudolf;
Vernes, Sonja C;
Knörnschild, Mirjam;
Wiegrebe, Lutz.
(2021)
Hearing sensitivity and amplitude coding in bats are differentially shaped by echolocation calls and social calls.
Proceedings of the Royal Society of London. Biological Sciences
Vitenskapelig artikkel
-
Luecke, Vivian Nancy;
Buchwieser, Laura;
zu Eulenburg, Peter;
Marquart, Torsten;
Drexl, Markus Rudolf.
(2020)
Ocular and cervical vestibular evoked myogenic potentials elicited by air-conducted, low-frequency sound.
Journal of Vestibular Research-Equilibrium & Orientation
Vitenskapelig artikkel
-
Fischl, Matthew J;
Ueberfuhr, Margarete A;
Drexl, Markus Rudolf;
Pagella, Sara;
Sinclair, James;
Alexandrova, Olga.
(2019)
Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise-induced threshold shift.
Journal of Physiology
Vitenskapelig artikkel
-
Ueberfuhr, Margarete A;
Drexl, Markus Rudolf.
(2019)
Slow oscillatory changes of DPOAE magnitude and phase after exposure to intense low-frequency sounds.
Journal of Neurophysiology
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Krause, Eike;
Gürkov, Robert.
(2018)
A Comparison of Distortion Product Otoacoustic Emission Properties in Ménière's Disease Patients and Normal-Hearing Participants.
Ear and Hearing
Vitenskapelig artikkel
-
Jeanson, Lena;
Wiegrebe, Lutz;
Gürkov, Robert;
Krause, Eike;
Drexl, Markus Rudolf.
(2017)
Aftereffects of Intense Low-Frequency Sound on Spontaneous Otoacoustic Emissions: Effect of Frequency and Level.
Journal of the Association for Research in Otolaryngology
Vitenskapelig artikkel
-
Ueberfuhr, Margarete A;
Wiegrebe, Lutz;
Krause, Eike;
Gürkov, Robert;
Drexl, Markus Rudolf.
(2017)
Tinnitus in Normal-Hearing Participants after Exposure to Intense Low-Frequency Sound and in Ménière's Disease Patients.
Frontiers in Neurology
Vitenskapelig artikkel
-
Ueberfuhr, Margarete A;
Braun, Amalia;
Wiegrebe, Lutz;
Grothe, Benedikt;
Drexl, Markus Rudolf.
(2017)
Modulation of auditory percepts by transcutaneous electrical stimulation.
Hearing Research
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Wiegrebe, Lutz;
Otto, Larissa;
Marquart, Torsten;
Gürkov, Robert;
Krause, Eike.
(2016)
Low-frequency sound exposure causes reversible long-term changes of cochlear transfer characteristics.
Hearing Research
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Krause, Eike;
Gürkov, Robert;
Wiegrebe, Lutz.
(2016)
Responses of the Human Inner Ear to Low-Frequency Sound.
Advances in Experimental Medicine and Biology
Vitenskapelig artikkel
-
Kugler, Kathrin;
Wiegrebe, Lutz;
Gürkov, Robert;
Krause, Eike;
Drexl, Markus Rudolf.
(2015)
Concurrent Acoustic Activation of the Medial Olivocochlear System Modifies the After-Effects of Intense Low-Frequency Sound on the Human Inner Ear.
Journal of the Association for Research in Otolaryngology
Vitenskapelig artikkel
-
Kugler, Kathrin;
Grothe, Benedikt;
Kössl, Manfred;
Gurkov, Robert;
Krause, Eike;
Drexl, Markus Rudolf.
(2014)
Low-frequency sound affects active micromechanics in the human inner ear.
Royal Society Open Science
Vitenskapelig artikkel
-
Weddell, Thomas D;
Yarin, Yury M;
Drexl, Markus Rudolf;
Russell, Ian J;
Elliott, Stephen J;
Lukashkin, Andrei N.
(2014)
A novel mechanism of cochlear excitation during simultaneous stimulation and pressure relief through the round window.
Journal of the Royal Society Interface
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Ueberfuhr, Margarete A;
Weddell, Thomas D;
Lukashkin, Andrei N;
Wiegrebe, Lutz;
Krause, Eike.
(2014)
Multiple indices of the 'bounce' phenomenon obtained from the same human ears.
Journal of the Association for Research in Otolaryngology
Vitenskapelig artikkel
-
Kantner, Claudia;
Hapflmeier, Alexander;
Drexl, Markus Rudolf;
Gürkov, Robert.
(2014)
The effects of rise/fall time and plateau time on ocular vestibular evoked myogenic potentials.
European Archives of Oto-Rhino-Laryngology
Vitenskapelig artikkel
-
Krause, Eike;
Mayerhofer, Andreas;
Gürkov, Robert;
Drexl, Markus Rudolf;
Braun, Thomas;
Olzowy, Berhard.
(2013)
Effects of acoustic stimuli used for vestibular evoked myogenic potential studies on the cochlear function.
Otology & Neurotology
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Gürkov, Robert;
Krause, Eike.
(2012)
Low-frequency modulated quadratic and cubic distortion product otoacoustic emissions in humans.
Hearing Research
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Mellado Lagarde, Marcia M;
Zuo, Jian;
Lukashkin, Andrei N;
Russell, Ian.
(2008)
The role of prestin in the generation of electrically evoked otoacoustic emissions in mice.
Journal of Neurophysiology
Vitenskapelig artikkel
-
Mellado Lagarde, Marcia M;
Drexl, Markus Rudolf;
Lukashkin, Andrei N;
Zuo, Jian;
Russell, Ian.
(2008)
Prestin's role in cochlear frequency tuning and transmission of mechanical responses to neural excitation.
Current Biology
Vitenskapelig artikkel
-
Mellado Lagarde, Marcia M;
Drexl, Markus Rudolf;
Lukashkina, Victoria A;
Lukashkin, Andrei N;
Russell, Ian J.
(2008)
Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier.
Nature Neuroscience
Vitenskapelig artikkel
-
Wittekindt, Anna;
Drexl, Markus Rudolf;
Kössl, Manfred.
(2005)
Cochlear sensitivity in the lesser spear-nosed bat, Phyllostomus discolor.
Journal of Comparative Physiology A. Sensory, neural, and behavioral physiology
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Kössl, Manfred;
Henke, Julia.
(2004)
Isoflurane increases amplitude and incidence of evoked and spontaneous otoacoustic emissions.
Hearing Research
Vitenskapelig artikkel
-
Russell, Ian;
Drexl, Markus Rudolf;
Foeller, Elisabeth;
Vater, Marianne;
Kössl, Manfred.
(2003)
The development of a single frequency place in the mammalian cochlea: the cochlear resonance in the mustached bat Pteronotus parnellii.
Journal of Neuroscience
Vitenskapelig artikkel
-
Russell, Ian;
Drexl, Markus Rudolf;
Foeller, Elisabeth;
Vater, Marianne;
Kössl, Manfred.
(2003)
Synchronization of a nonlinear oscillator: processing the cf component of the echo-response signal in the cochlea of the mustached bat.
Journal of Neuroscience
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Faulstich, Michael;
von Stebut, Boris;
Radtke-Schuller, Susanne;
Kössl, Manfred.
(2003)
Distortion product otoacoustic emissions and auditory evoked potentials in the hedgehog tenrec, Echinops telfairi.
Journal of the Association for Research in Otolaryngology
Vitenskapelig artikkel
-
Drexl, Markus Rudolf;
Kössl, Manfred.
(2003)
Sound-evoked efferent effects on cochlear mechanics of the mustached bat.
Hearing Research
Vitenskapelig artikkel
-
Kössl, Manfred;
Foeller, Elisabeth;
Drexl, Markus Rudolf;
Vater, Marianne;
Mora, Emanuel;
Coro, Frank.
(2003)
Postnatal development of cochlear function in the mustached bat, Pteronotus parnellii.
Journal of Neurophysiology
Vitenskapelig artikkel
-
Pibal, Iris;
Drexl, Markus Rudolf;
Kössl, Manfred.
(2002)
Level dependence of optimal stimulus level difference for evoking DPOAEs in the gerbil.
Hearing Research
Vitenskapelig artikkel