Marit Otterlei
Om
Curriculum:
- 2010- CSO, APIM Therapeutics AS, Trondheim (deltid)
- 2003- Professor, Fakultet for medisin og helsevitenskap, Institutt for klinisk og molekylær medisin (IKOM), NTNU, Norges teknisk-naturvitenskapelige universitet, Trondheim (hovedstilling).
- Gjesteforsker ved Centre de Rescherche en Cancerologies de Marseille (CRCM), Frankrike (vårsemester) and Institutt for biologi, Universitetet i København, Danmark (høstsemester), 2019.
- Gjesteforsker ved Laboratory of Molecular Gerontology, National Institute on Aging, National Institute of Health, Baltimore, USA, 2002-2003.
- Startet egen forskningsgruppe i 2002 ved institutt for kreftforskning NTNU etter å ha fått karrierestipend fra forskningsrådet på prosjektet “Replication associated DNA repair”, 2002-2006.
- Førsteamanuensis II, UNIGEN, Center for Molekylærbiologi and Institutt for kreftforskning, Universitetet i Trondheim (UNIT) (nå NTNU), 1988-2002.
- Postdoktor, DNA reparasjon, UNIGEN, Senter for molekylærbiologi, UNIT, Trondheim, 1994-2001.
- PhD (Dr.ing) innenfor medfødt immunitet ved Institutt for Bioteknologi og Institutt for kreftforskning, Norges Tekniske Høyskole (NTH)/ UNIT (nå NTNU), 1994.
- MSc (Siv.ing), Institutt for Bioteknologi, NTH (nå NTNU), 1988.
Proteiner som tilhører DNA clamp familien er strukturelt konserverte mellom bakterier og mennesker. Disse proteinene har en sentral rolle i prosessene som kopierer DNAet i celler før celledeling. Nyere forskning blant annet fra Otterleis forskningsgruppe har vist at disse proteinene også er involvert i andre cellulære prosesser som er viktig for cellenes evne til å håndtere stress. At disse proteinene er så sentrale i cellenes evne til å håndtere stress gjør dem interessante som målprotein i behandling både for kreft og infeksjoner.
Basert på den vitenskapelige oppdagelsen av det nye bindingsmotivet for den humane DNA clampen, PCNA, ble NTNU spin-off selskapet APIM Therapeutics etablert i 2009. Dette selskapet utvikler et peptid (lite protein) for bruk i kreftbehandling. Dette peptidet inneholder det nye bindingsmotivet. Otterlei er vitenskapelig ansvarlig i dette selskapet (CSO) (https://www.apimtherapeutics.com/). Det gjøres nå kliniske studier av peptidet (fase I), og videre fase II studier er under planlegging
Under et av kreftstudiene av peptidet fikk man uheldigvis en bakterieinfeksjon i cellekulturene. Da viste det seg, noe overaskende, at disse peptidene også hadde antibakterielle effekter. Noen av disse effektene skyldes trolig at peptidene binder til den bakteriell DNA clampen.
Gruppens hovedfokus nå er studier av effekten peptidet har på bakterielle stressresponser, inkludert bakteriens evne til å mutere. Otterlei leder ett av fire nasjonale prosjekter for forskning på AMR (anti-mikrobiell resistense/antibiotika resistens) støttet av Trond Mohn Stiftelsen (https://mohnfoundation.no/amr-prosjekter/); «Bekjempelse av AMR ved inhibering av bakterielle stress responser» (Targeting AMR by inhibition of bacterial stress responses, TAMiR), (https://www.ntnu.edu/ikom/tamir#/view/about).
Prosjektets mål er å utvikle anti-mikrobielle peptider som angriper bakteriene på en nye måte og/eller på en måte som hindrer utvikling av resistens.
Fra venstre: Siri Bachke, Amanda Holstad Singleton, Olaug Elisabeth Torheim Bergum, Marit Otterlei, Synnøve Brandt Ræder, Caroline Krogh Søgaard og Anala Nepal.
For vitenskapelige detaljer, se engelsk versjon.
Publikasjoner
2022
-
Lemech, Charlotte Rose;
Kichenadasse, Ganessan;
Marschner, Jens-Peter;
Alevizopoulos, Konstantinos;
Otterlei, Marit;
Millward, Michael.
(2022)
ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study.
Oncogene.
Vitenskapelig artikkel
-
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim;
Bruheim, Per;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics.
volum 11 (8).
Vitenskapelig artikkel
-
Gravina, Giovanni Luca;
Colapietro, Alessandro;
Andrea, Mancini;
Rossetti, Alessandra;
Martelucci, Stefano;
Ventura, Luca;
Di Franco, Martina;
Marampon, Francesco;
Mattei, Vinvenzo;
Biordi, Leda Assunta;
Otterlei, Marit;
Festuccia, Claudio.
(2022)
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma.
Cancers.
Vitenskapelig artikkel
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per;
Otterlei, Marit.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene.
Vitenskapelig artikkel
2021
-
Blindheim, Fredrik Heen;
Olsen, Cecilie Elisabeth;
Søgaard, Caroline Krogh;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2021)
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents.
European Journal of Organic Chemistry.
Vitenskapelig artikkel
-
Frimodt-Møller, Jakob;
Koulouktsis, Andreas;
Charbon, Godefroid;
Otterlei, Marit;
Nielsen, Peter E.;
Løbner-Olesen, Anders.
(2021)
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli.
Molecular Therapy - Nucleic Acids.
volum 25.
Vitenskapelig artikkel
-
Nepal, Anala;
Ræder, Synnøve Brandt;
Søgaard, Caroline Krogh;
Haugan, Maria Schei;
Otterlei, Marit.
(2021)
Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization.
Frontiers in Microbiology.
Vitenskapelig artikkel
-
Ræder, Synnøve Brandt;
Sandbakken, Erik Thorvaldsen;
Nepal, Anala;
Løseth, Kirsti;
Bergh, Kåre;
Witsø, Eivind;
Otterlei, Marit.
(2021)
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo.
Frontiers in Microbiology.
Vitenskapelig artikkel
-
Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2021)
Differentially expressed extracellular vesicle-contained micrornas before and after transurethral resection of bladder tumors.
Current Issues in Molecular Biology.
volum 43 (1).
Vitenskapelig artikkel
-
Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia;
Duodu, Samuel;
Bruheim, Per;
Otterlei, Marit.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules.
volum 11 (6).
Vitenskapelig artikkel
2020
-
Nedal, Aina;
Ræder, Synnøve Brandt;
Dalhus, Bjørn;
Helgesen, Emily;
Forstrøm, Rune Johansen;
Lindland, Kim;
Sumabe, Balagra Kasim;
Martinsen, Jacob H.;
Kragelund, Birthe B.;
Skarstad, Kirsten Jane;
Bjørås, Magnar;
Otterlei, Marit.
(2020)
Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis.
Nucleic Acids Research (NAR).
volum 48 (10).
Vitenskapelig artikkel
-
Seelinger, Mareike;
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2020)
The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type.
Biomolecules.
volum 10 (3).
Vitenskapelig artikkel
-
Seelinger, Mareike;
Otterlei, Marit.
(2020)
Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA).
International Journal of Molecular Sciences.
volum 21 (693).
Vitenskapelig artikkel
2019
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian;
Bradamante, Stefano;
Aas, Per Arne;
Furrer, Antonia;
Olsen, Lene Christin;
Kunath, Nicolas;
Otterlei, Marit;
Sætrom, Pål;
Bjørås, Magnar;
Samson, Leona D.;
van Loon, Barbara.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications.
volum 10 (1).
Vitenskapelig artikkel
-
Prestel, Andreas;
Wichmann, Nanna;
Martins, Joao M;
Marabini, Riccardo;
Kassem, Noah;
Broendum, Sebastian S;
Otterlei, Marit;
Nielsen, Olaf;
Willemoës, Martin;
Ploug, Michael;
Boomsma, Wouter;
Kragelund, Birthe B.
(2019)
The PCNA interaction motifs revisited: thinking outside the PIP-box.
Cellular and Molecular Life Sciences (CMLS).
volum 76 (24).
Vitenskapelig artikkel
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel;
Zhang, Beibei;
Vågbø, Cathrine Broberg;
Kusnierczyk, Anna;
Gilljam, Karin Margaretha;
Løvkvam-Køster, Maiken Caroline;
Otterlei, Marit;
Dahl, John Arne;
Enserink, Jorrit;
Klungland, Arne;
Robertson, Adam Brian.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports.
volum 9.
Vitenskapelig artikkel
-
Søgaard, Caroline Krogh;
Nepal, Anala;
Petrovic, Voin;
Sharma, Animesh;
Liabakk, Nina-Beate;
Steigedal, Tonje S.;
Otterlei, Marit.
(2019)
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy.
OncoTarget.
volum 10 (68).
Vitenskapelig artikkel
2018
-
Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn;
Otterlei, Marit.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio.
volum 8 (7).
Vitenskapelig artikkel
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh;
Røst, Lisa Marie;
Misund, Kristine;
Andreassen, Trygve;
Melø, Torun Margareta;
Bartosova, Zdenka;
Bruheim, Per;
Otterlei, Marit.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients.
volum 10 (4).
Vitenskapelig artikkel
-
Ræder, Synnøve Brandt;
Nepal, Anala;
Bjørås, Karine;
Seelinger, Mareike;
Kolve, Rønnaug Steen;
Nedal, Aina;
Müller, Rebekka;
Otterlei, Marit.
(2018)
APIM-mediated REV3L?PCNA interaction important for error free TLS over UV-induced DNA lesions in human cells.
International Journal of Molecular Sciences.
volum 20 (1).
Vitenskapelig artikkel
-
Søgaard, Caroline Danielsen;
Moestue, Siver Andreas;
Rye, Morten Beck;
Kim, Jana;
Nepal, Anala;
Liabakk, Nina-Beate;
Bachke, Siri;
Bathen, Tone Frost;
Otterlei, Marit;
Hill, Deborah Katherine.
(2018)
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
OncoTarget.
volum 9 (14).
Vitenskapelig artikkel
-
Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri;
Liabakk, Nina-Beate;
Gederaas, Odrun Arna;
Viset, Trond;
Arum, Carl-Jørgen;
Bruheim, Per;
Otterlei, Marit.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget.
volum 9 (65).
Vitenskapelig artikkel
2017
-
Bjørås, Karine;
Sousa, Mirta;
Sharma, Animesh;
Fonseca, Davi de Miranda;
Søgaard, Caroline Danielsen;
Bjørås, Magnar;
Otterlei, Marit.
(2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Nucleic Acids Research (NAR).
volum 45 (14).
Vitenskapelig artikkel
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik;
Hoff, Bård Helge;
Slupphaug, Geir;
Otterlei, Marit.
(2017)
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel.
Data in Brief.
volum 12.
Vitenskapelig artikkel
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik;
Hoff, Bård Helge;
Slupphaug, Geir;
Otterlei, Marit.
(2017)
On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay.
Analytical Biochemistry.
volum 523.
Vitenskapelig artikkel
-
Sousa, Mirta;
Bjørås, Karine;
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Otterlei, Marit.
(2017)
P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.
Scientific Reports.
volum 7 (1).
Vitenskapelig artikkel
2016
-
Marstad, Anne;
Landsverk, Ole J. B.;
Strømme, Olaf;
Otterlei, Marit;
Collas, Philippe;
Sundan, Anders;
Brede, Gaute.
(2016)
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.
The FEBS Journal.
volum 283 (4).
Vitenskapelig artikkel
2015
-
Olaisen, Camilla;
Müller, Rebekka;
Nedal, Aina;
Otterlei, Marit.
(2015)
PCNA-interacting peptides reduce Akt phophorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.
Cellular Signalling.
volum 27 (7).
Vitenskapelig artikkel
2014
-
Baglo, Yan;
Hagen, Lars;
Høgset, Anders;
Drabløs, Finn;
Otterlei, Marit;
Gederaas, Odrun Arna.
(2014)
Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.
BioMed Research International.
volum 14 (74).
Vitenskapelig artikkel
-
Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen;
Otterlei, Marit.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology.
volum 7 (6).
Vitenskapelig artikkel
2013
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair.
volum 12 (1).
Vitenskapelig artikkel
-
Müller, Rebekka;
Misund, Kristine;
Holien, Toril;
Bachke, Siri;
Gilljam, Karin Margaretha;
Våtsveen, Thea Kristin;
Rø, Torstein Baade;
Bellacchio, E.;
Sundan, Anders;
Otterlei, Marit.
(2013)
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells.
PLOS ONE.
volum 8 (7).
Vitenskapelig artikkel
2012
-
Bjørnstad, Linn;
Meza, Trine Johansen;
Otterlei, Marit;
Olafsrud, Solveig Mjelstad;
Meza-Zepeda, Leonardo Andrés;
Falnes, Pål.
(2012)
Human ALKBH4 Interacts with Proteins Associated with Transcription.
PLOS ONE.
volum 7 (11).
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Müller, Rebekka;
Liabakk, Nina-Beate;
Otterlei, Marit.
(2012)
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.
PLOS ONE.
volum 7 (11).
Vitenskapelig artikkel
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Akbari, Mansour;
Otterlei, Marit.
(2012)
X-ray repair cross complementing protein 1 in base excision repair.
International Journal of Molecular Sciences.
volum 13 (12).
Vitenskapelig oversiktsartikkel/review
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Gilljam, Karin Margaretha;
Torseth, Kathrin;
Wilson, David M.;
Akbari, Mansour;
Otterlei, Marit.
(2012)
The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1.
DNA Repair.
volum 11 (4).
Vitenskapelig artikkel
-
Otterlei, Marit;
Müller, R.;
Gilljam, Karin Margaretha;
Holien, Toril;
Midsund, K.;
Vatsveen, TK;
Ro, T.B.;
Bellacchio, E.;
Sundan, Anders.
(2012)
PEPTIDES COMPRISING THE NOVEL PCNA INTERACTING SEQUENCE APIM, INCREASES THE CYTOTOXICITY OF CHEMOTHERAPEUTIC DRUGS BY IMPAIRING THE CELLS DEFENSE MECHANISMS.
Annals of Oncology.
volum 23.
Sammendrag/abstract
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi;
Durandy, Anne;
Otterlei, Marit;
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair.
volum 11 (6).
Vitenskapelig artikkel
2011
-
Alevizopoulos, K;
Otterlei, Marit.
(2011)
ATX-101, a novel APIM-motif comprising peptide drug potentiates the action of several chemotherapeutic drugs by blocking the interaction between PCNA and key proteins involved in DNA repair and cell cycle control.
Annals of Oncology.
volum 22.
Sammendrag/abstract
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Sundheim, Ottar;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Slupphaug, Geir;
Krokan, Hans Einar;
Wilson, David M.;
Akbari, Mansour;
Otterlei, Marit.
(2011)
XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage.
Environmental and Molecular Mutagenesis.
volum 52 (8).
Vitenskapelig artikkel
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar;
Otterlei, Marit;
Bruheim, Per.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods.
volum 87 (3).
Vitenskapelig artikkel
2010
-
Akbari, Mansour;
Solvang-Garten, Karin;
Hanssen-Bauer, Audun;
Lieske, Nora V.;
Pettersen, Henrik P Sahlin;
Pettersen, Grete Klippenvåg;
Wilson, DM;
Krokan, Hans Einar;
Otterlei, Marit.
(2010)
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA Repair.
volum 9 (7).
Vitenskapelig artikkel
-
Arum, Carl-Jørgen;
Kodama, Yosuke;
Rolim, Natale Pinheiro Lage;
Widerøe, Marius;
Anderssen, Endre;
Viset, Trond;
Otterlei, Marit;
Lundgren, Steinar;
Chen, Duan;
Zhao, Chun-Mei.
(2010)
A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma.
World Journal of Urology.
volum 28 (4).
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer.
volum 8 (5).
Sammendrag/abstract
2009
-
Akbari, Mansour;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Liabakk, Nina-Beate;
Otterlei, Marit;
Krokan, Hans Einar.
(2009)
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.
DNA Repair.
volum 8 (7).
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg;
Catterall, Tara;
Liabakk, Nina-Beate;
Slupphaug, Geir;
Drabløs, Finn;
Krokan, Hans Einar;
Otterlei, Marit.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology.
volum 186 (5).
Vitenskapelig artikkel
-
Langevin, C;
Maidou-Peindara, P;
Aas, Per Arne;
Jacquot, G;
Otterlei, Marit;
Slupphaug, Geir;
Benichou, S.
(2009)
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect.
Journal of Virology.
volum 83 (19).
Vitenskapelig artikkel
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour;
Otterlei, Marit;
Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences.
volum 364 (1517).
Vitenskapelig oversiktsartikkel/review
2008
-
Akbari, Mansour;
Visnes, Torkild;
Krokan, Hans Einar;
Otterlei, Marit.
(2008)
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
DNA Repair.
volum 7.
Vitenskapelig artikkel
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar;
Diaz, Javier Pena;
Otterlei, Marit;
Hørning, Ole;
Jensen, Ole N;
Krokan, Hans Einar;
Slupphaug, Geir.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal.
volum 27 (1).
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete;
Hagen, Lars;
Sundheim, Ottar;
Akbari, Mansour;
Liabakk, Nina-Beate;
Slupphaug, Geir;
Otterlei, Marit;
Krokan, Hans Einar.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry.
volum 238 (36).
Vitenskapelig artikkel
2007
-
Akbari, Mansour;
Otterlei, Marit;
Pena-Diaz, J;
Krokan, Hans Einar.
(2007)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience.
volum 145.
Vitenskapelig artikkel
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology.
volum 8 (6).
Vitenskapelig oversiktsartikkel/review
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair.
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Hagen, Lars;
Otterlei, Marit;
Gilljam, Karin Margaretha;
Slupphaug, Geir.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair.
Sammendrag/abstract
2006
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Krokan, Hans Einar.
(2006)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience.
Vitenskapelig artikkel
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research.
volum 312.
Vitenskapelig oversiktsartikkel/review
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene;
Aarset, Harald;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal.
volum 273.
Sammendrag/abstract
-
Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy;
Bohr, Vilhelm A..
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science.
volum 119 (24).
Vitenskapelig artikkel
2005
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A;
Durandy, A;
Krokan, Hans Einar;
Slupphaug, Geir.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM).
volum 201.
Vitenskapelig artikkel
-
Luna, Gomez Luisa;
Luna, L;
Rolseth, V;
Hildrestrand, GA;
Otterlei, Marit;
Dantzer, F;
Bjørås, Magnar;
Bjoras, M;
Seeberg, E.
(2005)
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys(326) polymorphic variant.
Nucleic Acids Research (NAR).
volum 33.
Vitenskapelig artikkel
-
Pohler, JRG;
Otterlei, Marit;
Warbrick, E.
(2005)
An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit.
BMC Molecular Biology.
volum 6.
Vitenskapelig artikkel
2004
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate;
Hagen, Lars;
Imai, K;
Durandy, A;
Slupphaug, Geir;
Krokan, Hans Einar.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR).
volum 32.
Vitenskapelig artikkel
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud;
Diaz, Javier Pena;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair.
volum 3 (11).
Vitenskapelig oversiktsartikkel/review
-
Fan, JS;
Otterlei, Marit;
Wong, HK;
Tomkinson, AE;
Wilson, DM.
(2004)
XRCC1 co-localizes and physically interacts with PCNA.
Nucleic Acids Research (NAR).
volum 32 (7).
Vitenskapelig artikkel
-
Opresko, PL;
Otterlei, Marit;
Graakjaer, J;
Bruheim, P;
Dawut, L;
Kolvraa, S;
May, A;
Seidman, MM;
Bohr, VA.
(2004)
The Werner syndrome helicase and exonuclease cooperate to resolve telometric D-loops in a manner regulated by TRF1 and TRF2.
Molecular Cell.
Vitenskapelig artikkel
-
Sharma, S;
Otterlei, Marit;
Sommers, JA;
Driscoll, HC;
Dianov, GL;
Kao, HI;
Bambara, RA;
Brosh, RM.
(2004)
WRN helicase and Flap endonuclease 1 forms a complex upon replication arrest and together process branch-migrating DNA structures associated with the replication fork.
Molecular Biology of the Cell.
volum 15 (2).
Vitenskapelig artikkel
2003
-
Baynton, Kathy;
Otterlei, Marit;
Bjørås, M.;
von Kobbe, Cayetano;
Bohr, Vilhelm;
Seeberg, E..
(2003)
WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*.
JBC Papers in Press.
volum 278 (38).
Vitenskapelig artikkel
-
Bayton, Kathy;
Otterlei, Marit;
Bjørås, Magnar;
Kobbe, C von;
Bohr, V.A.;
Seeberg, Erling Christen.
(2003)
WRN interacts physically and functionally with the recombination mediator protein RAD52.
Journal of Biological Chemistry.
volum 278.
Vitenskapelig artikkel
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour;
Sundheim, Ottar;
Bjørås, Magnar;
Slupphaug, Geir;
Seeberg, Erling Christen;
Krokan, Hans Einar.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature.
volum 421.
Vitenskapelig artikkel
2002
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank;
Aas, Per Arne;
Hagen, Lars;
Krokan, Hans Einar;
Slupphaug, Geir.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry.
volum 18.
Vitenskapelig artikkel
2001
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja;
Skjelbred, Camilla Furu;
Akbari, Mansour;
Aas, Per Arne;
Slupphaug, Geir.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology.
volum 68.
Vitenskapelig artikkel
2000
-
Krokan, Hans Einar;
Nilsen, H.;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair in mammalian cells.
FEBS Letters.
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, Hilde;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair of DNA in mammalian cells.
FEBS Letters.
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR).
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR).
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal.
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal.
Vitenskapelig artikkel
1999
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde;
Skjelbred, Camilla;
Kavli, Bodil;
Standal, Rune;
Slupphaug, Geir.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences.
volum 302.
Vitenskapelig artikkel
-
Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour;
Aas, Per Arne;
Steinsbekk, Kristin;
Bakke, Oddmund;
Krokan, Hans Einar.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal.
volum 18 (13).
Vitenskapelig artikkel
1998
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Bharati, S.;
Krokan, Hans Einar;
Kristiansen, L;
Otterlei, Marit;
Slupphaug, Geir.
(1998)
Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
Nucleic Acids Research (NAR).
Vitenskapelig artikkel
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Mekanismer for intracellulær sortering av UNG-proteiner studert ved molekylærbiologiske og biofysiske metoder.
1998.
Rapport
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Holsve, Marianne;
Otterlei, Marit.
(1998)
Sekvenser i UNG2 som er viktige for UDG-aktivitet, Mg2eion stimulering og intracellulær sortering.
1998.
Rapport
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Jørgensen, Kjersti;
Otterlei, Marit.
(1998)
Human uracil DNA glycosylase. Egenskaper til enzymer med og uten presekvens.
1998.
Hovedfagsoppgave
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Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde;
Nagelhus-Hernes, T;
Haug, T;
Aas, Per A;
Akbari, M;
Skjelbred, Camilla;
Kavli, Bodil.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
1998. DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences..
Fagbok
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Otterlei, Marit;
Haug, T.;
Nagelhus, T.A;
Slupphaug, Geir;
Lindmo, T.;
Krokan, Hans Einar.
(1998)
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively.
Nucleic Acids Research (NAR).
volum 26 (20).
Vitenskapelig artikkel
1997
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Krokan, Hans Einar;
Standal, Rune;
Bharati, Sangeeta;
Otterlei, Marit;
Haug, Terje;
Slupphaug, Geir;
Skorpen, Frank.
(1997)
Uracil in DNA and the family of concerved uracil DNA glycosylases.
Base excision repair on DNA damage.
Vitenskapelig kapittel/artikkel
-
Nagelhus, T.;
Haug, T.;
Singh, K.K.;
Keshav, K.F.;
Skorpen, Frank;
Bharati, S.;
Otterlei, Marit;
Lindmo, T.;
Benichou, S.;
Benarous, R.;
Krokan, Hans Einar.
(1997)
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A.
Journal of Biological Chemistry.
Vitenskapelig artikkel
-
Nilsen, H.;
Otterlei, Marit;
Haug, T.;
Solum, K.;
Nagelhus, T.A;
Skorpen, Frank;
Krokan, Hans Einar.
(1997)
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
Nucleic Acids Research (NAR).
Vitenskapelig artikkel
1995
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Skjåk-Bræk, Gudmund;
Espevik, Terje;
Otterlei, Marit;
Smidsrød, Olav;
Soon-Shiong, P..
(1995)
Homologous guluronic acid alginate coating composition for in vivo application and implantation and method using the same.
1995. US-Patent 5459 054, Oct. 1995.
Rapport
Vitenskapelige artikler
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Lemech, Charlotte Rose;
Kichenadasse, Ganessan;
Marschner, Jens-Peter;
Alevizopoulos, Konstantinos;
Otterlei, Marit;
Millward, Michael.
(2022)
ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study.
Oncogene.
Vitenskapelig artikkel
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Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim;
Bruheim, Per;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics.
volum 11 (8).
Vitenskapelig artikkel
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Gravina, Giovanni Luca;
Colapietro, Alessandro;
Andrea, Mancini;
Rossetti, Alessandra;
Martelucci, Stefano;
Ventura, Luca;
Di Franco, Martina;
Marampon, Francesco;
Mattei, Vinvenzo;
Biordi, Leda Assunta;
Otterlei, Marit;
Festuccia, Claudio.
(2022)
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma.
Cancers.
Vitenskapelig artikkel
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per;
Otterlei, Marit.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene.
Vitenskapelig artikkel
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Blindheim, Fredrik Heen;
Olsen, Cecilie Elisabeth;
Søgaard, Caroline Krogh;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2021)
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents.
European Journal of Organic Chemistry.
Vitenskapelig artikkel
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Frimodt-Møller, Jakob;
Koulouktsis, Andreas;
Charbon, Godefroid;
Otterlei, Marit;
Nielsen, Peter E.;
Løbner-Olesen, Anders.
(2021)
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli.
Molecular Therapy - Nucleic Acids.
volum 25.
Vitenskapelig artikkel
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Nepal, Anala;
Ræder, Synnøve Brandt;
Søgaard, Caroline Krogh;
Haugan, Maria Schei;
Otterlei, Marit.
(2021)
Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization.
Frontiers in Microbiology.
Vitenskapelig artikkel
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Ræder, Synnøve Brandt;
Sandbakken, Erik Thorvaldsen;
Nepal, Anala;
Løseth, Kirsti;
Bergh, Kåre;
Witsø, Eivind;
Otterlei, Marit.
(2021)
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo.
Frontiers in Microbiology.
Vitenskapelig artikkel
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Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2021)
Differentially expressed extracellular vesicle-contained micrornas before and after transurethral resection of bladder tumors.
Current Issues in Molecular Biology.
volum 43 (1).
Vitenskapelig artikkel
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Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia;
Duodu, Samuel;
Bruheim, Per;
Otterlei, Marit.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules.
volum 11 (6).
Vitenskapelig artikkel
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Nedal, Aina;
Ræder, Synnøve Brandt;
Dalhus, Bjørn;
Helgesen, Emily;
Forstrøm, Rune Johansen;
Lindland, Kim;
Sumabe, Balagra Kasim;
Martinsen, Jacob H.;
Kragelund, Birthe B.;
Skarstad, Kirsten Jane;
Bjørås, Magnar;
Otterlei, Marit.
(2020)
Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis.
Nucleic Acids Research (NAR).
volum 48 (10).
Vitenskapelig artikkel
-
Seelinger, Mareike;
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2020)
The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type.
Biomolecules.
volum 10 (3).
Vitenskapelig artikkel
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Seelinger, Mareike;
Otterlei, Marit.
(2020)
Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA).
International Journal of Molecular Sciences.
volum 21 (693).
Vitenskapelig artikkel
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Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian;
Bradamante, Stefano;
Aas, Per Arne;
Furrer, Antonia;
Olsen, Lene Christin;
Kunath, Nicolas;
Otterlei, Marit;
Sætrom, Pål;
Bjørås, Magnar;
Samson, Leona D.;
van Loon, Barbara.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications.
volum 10 (1).
Vitenskapelig artikkel
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Prestel, Andreas;
Wichmann, Nanna;
Martins, Joao M;
Marabini, Riccardo;
Kassem, Noah;
Broendum, Sebastian S;
Otterlei, Marit;
Nielsen, Olaf;
Willemoës, Martin;
Ploug, Michael;
Boomsma, Wouter;
Kragelund, Birthe B.
(2019)
The PCNA interaction motifs revisited: thinking outside the PIP-box.
Cellular and Molecular Life Sciences (CMLS).
volum 76 (24).
Vitenskapelig artikkel
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Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel;
Zhang, Beibei;
Vågbø, Cathrine Broberg;
Kusnierczyk, Anna;
Gilljam, Karin Margaretha;
Løvkvam-Køster, Maiken Caroline;
Otterlei, Marit;
Dahl, John Arne;
Enserink, Jorrit;
Klungland, Arne;
Robertson, Adam Brian.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports.
volum 9.
Vitenskapelig artikkel
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Søgaard, Caroline Krogh;
Nepal, Anala;
Petrovic, Voin;
Sharma, Animesh;
Liabakk, Nina-Beate;
Steigedal, Tonje S.;
Otterlei, Marit.
(2019)
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy.
OncoTarget.
volum 10 (68).
Vitenskapelig artikkel
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Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn;
Otterlei, Marit.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio.
volum 8 (7).
Vitenskapelig artikkel
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Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh;
Røst, Lisa Marie;
Misund, Kristine;
Andreassen, Trygve;
Melø, Torun Margareta;
Bartosova, Zdenka;
Bruheim, Per;
Otterlei, Marit.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients.
volum 10 (4).
Vitenskapelig artikkel
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Ræder, Synnøve Brandt;
Nepal, Anala;
Bjørås, Karine;
Seelinger, Mareike;
Kolve, Rønnaug Steen;
Nedal, Aina;
Müller, Rebekka;
Otterlei, Marit.
(2018)
APIM-mediated REV3L?PCNA interaction important for error free TLS over UV-induced DNA lesions in human cells.
International Journal of Molecular Sciences.
volum 20 (1).
Vitenskapelig artikkel
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Søgaard, Caroline Danielsen;
Moestue, Siver Andreas;
Rye, Morten Beck;
Kim, Jana;
Nepal, Anala;
Liabakk, Nina-Beate;
Bachke, Siri;
Bathen, Tone Frost;
Otterlei, Marit;
Hill, Deborah Katherine.
(2018)
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
OncoTarget.
volum 9 (14).
Vitenskapelig artikkel
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Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri;
Liabakk, Nina-Beate;
Gederaas, Odrun Arna;
Viset, Trond;
Arum, Carl-Jørgen;
Bruheim, Per;
Otterlei, Marit.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget.
volum 9 (65).
Vitenskapelig artikkel
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Bjørås, Karine;
Sousa, Mirta;
Sharma, Animesh;
Fonseca, Davi de Miranda;
Søgaard, Caroline Danielsen;
Bjørås, Magnar;
Otterlei, Marit.
(2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Nucleic Acids Research (NAR).
volum 45 (14).
Vitenskapelig artikkel
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Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik;
Hoff, Bård Helge;
Slupphaug, Geir;
Otterlei, Marit.
(2017)
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel.
Data in Brief.
volum 12.
Vitenskapelig artikkel
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Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik;
Hoff, Bård Helge;
Slupphaug, Geir;
Otterlei, Marit.
(2017)
On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay.
Analytical Biochemistry.
volum 523.
Vitenskapelig artikkel
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Sousa, Mirta;
Bjørås, Karine;
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Otterlei, Marit.
(2017)
P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.
Scientific Reports.
volum 7 (1).
Vitenskapelig artikkel
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Marstad, Anne;
Landsverk, Ole J. B.;
Strømme, Olaf;
Otterlei, Marit;
Collas, Philippe;
Sundan, Anders;
Brede, Gaute.
(2016)
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.
The FEBS Journal.
volum 283 (4).
Vitenskapelig artikkel
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Olaisen, Camilla;
Müller, Rebekka;
Nedal, Aina;
Otterlei, Marit.
(2015)
PCNA-interacting peptides reduce Akt phophorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.
Cellular Signalling.
volum 27 (7).
Vitenskapelig artikkel
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Baglo, Yan;
Hagen, Lars;
Høgset, Anders;
Drabløs, Finn;
Otterlei, Marit;
Gederaas, Odrun Arna.
(2014)
Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.
BioMed Research International.
volum 14 (74).
Vitenskapelig artikkel
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Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen;
Otterlei, Marit.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology.
volum 7 (6).
Vitenskapelig artikkel
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Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair.
volum 12 (1).
Vitenskapelig artikkel
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Müller, Rebekka;
Misund, Kristine;
Holien, Toril;
Bachke, Siri;
Gilljam, Karin Margaretha;
Våtsveen, Thea Kristin;
Rø, Torstein Baade;
Bellacchio, E.;
Sundan, Anders;
Otterlei, Marit.
(2013)
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells.
PLOS ONE.
volum 8 (7).
Vitenskapelig artikkel
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Bjørnstad, Linn;
Meza, Trine Johansen;
Otterlei, Marit;
Olafsrud, Solveig Mjelstad;
Meza-Zepeda, Leonardo Andrés;
Falnes, Pål.
(2012)
Human ALKBH4 Interacts with Proteins Associated with Transcription.
PLOS ONE.
volum 7 (11).
Vitenskapelig artikkel
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Gilljam, Karin Margaretha;
Müller, Rebekka;
Liabakk, Nina-Beate;
Otterlei, Marit.
(2012)
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.
PLOS ONE.
volum 7 (11).
Vitenskapelig artikkel
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Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Gilljam, Karin Margaretha;
Torseth, Kathrin;
Wilson, David M.;
Akbari, Mansour;
Otterlei, Marit.
(2012)
The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1.
DNA Repair.
volum 11 (4).
Vitenskapelig artikkel
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Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi;
Durandy, Anne;
Otterlei, Marit;
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair.
volum 11 (6).
Vitenskapelig artikkel
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Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Sundheim, Ottar;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Slupphaug, Geir;
Krokan, Hans Einar;
Wilson, David M.;
Akbari, Mansour;
Otterlei, Marit.
(2011)
XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage.
Environmental and Molecular Mutagenesis.
volum 52 (8).
Vitenskapelig artikkel
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Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar;
Otterlei, Marit;
Bruheim, Per.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods.
volum 87 (3).
Vitenskapelig artikkel
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Akbari, Mansour;
Solvang-Garten, Karin;
Hanssen-Bauer, Audun;
Lieske, Nora V.;
Pettersen, Henrik P Sahlin;
Pettersen, Grete Klippenvåg;
Wilson, DM;
Krokan, Hans Einar;
Otterlei, Marit.
(2010)
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA Repair.
volum 9 (7).
Vitenskapelig artikkel
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Arum, Carl-Jørgen;
Kodama, Yosuke;
Rolim, Natale Pinheiro Lage;
Widerøe, Marius;
Anderssen, Endre;
Viset, Trond;
Otterlei, Marit;
Lundgren, Steinar;
Chen, Duan;
Zhao, Chun-Mei.
(2010)
A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma.
World Journal of Urology.
volum 28 (4).
Vitenskapelig artikkel
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Akbari, Mansour;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Liabakk, Nina-Beate;
Otterlei, Marit;
Krokan, Hans Einar.
(2009)
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.
DNA Repair.
volum 8 (7).
Vitenskapelig artikkel
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Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg;
Catterall, Tara;
Liabakk, Nina-Beate;
Slupphaug, Geir;
Drabløs, Finn;
Krokan, Hans Einar;
Otterlei, Marit.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology.
volum 186 (5).
Vitenskapelig artikkel
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Langevin, C;
Maidou-Peindara, P;
Aas, Per Arne;
Jacquot, G;
Otterlei, Marit;
Slupphaug, Geir;
Benichou, S.
(2009)
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect.
Journal of Virology.
volum 83 (19).
Vitenskapelig artikkel
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Akbari, Mansour;
Visnes, Torkild;
Krokan, Hans Einar;
Otterlei, Marit.
(2008)
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
DNA Repair.
volum 7.
Vitenskapelig artikkel
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Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar;
Diaz, Javier Pena;
Otterlei, Marit;
Hørning, Ole;
Jensen, Ole N;
Krokan, Hans Einar;
Slupphaug, Geir.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal.
volum 27 (1).
Vitenskapelig artikkel
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Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete;
Hagen, Lars;
Sundheim, Ottar;
Akbari, Mansour;
Liabakk, Nina-Beate;
Slupphaug, Geir;
Otterlei, Marit;
Krokan, Hans Einar.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry.
volum 238 (36).
Vitenskapelig artikkel
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Akbari, Mansour;
Otterlei, Marit;
Pena-Diaz, J;
Krokan, Hans Einar.
(2007)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience.
volum 145.
Vitenskapelig artikkel
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Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair.
Vitenskapelig artikkel
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Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Krokan, Hans Einar.
(2006)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience.
Vitenskapelig artikkel
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Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy;
Bohr, Vilhelm A..
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science.
volum 119 (24).
Vitenskapelig artikkel
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Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A;
Durandy, A;
Krokan, Hans Einar;
Slupphaug, Geir.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM).
volum 201.
Vitenskapelig artikkel
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Luna, Gomez Luisa;
Luna, L;
Rolseth, V;
Hildrestrand, GA;
Otterlei, Marit;
Dantzer, F;
Bjørås, Magnar;
Bjoras, M;
Seeberg, E.
(2005)
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys(326) polymorphic variant.
Nucleic Acids Research (NAR).
volum 33.
Vitenskapelig artikkel
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Pohler, JRG;
Otterlei, Marit;
Warbrick, E.
(2005)
An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit.
BMC Molecular Biology.
volum 6.
Vitenskapelig artikkel
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Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate;
Hagen, Lars;
Imai, K;
Durandy, A;
Slupphaug, Geir;
Krokan, Hans Einar.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR).
volum 32.
Vitenskapelig artikkel
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Fan, JS;
Otterlei, Marit;
Wong, HK;
Tomkinson, AE;
Wilson, DM.
(2004)
XRCC1 co-localizes and physically interacts with PCNA.
Nucleic Acids Research (NAR).
volum 32 (7).
Vitenskapelig artikkel
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Opresko, PL;
Otterlei, Marit;
Graakjaer, J;
Bruheim, P;
Dawut, L;
Kolvraa, S;
May, A;
Seidman, MM;
Bohr, VA.
(2004)
The Werner syndrome helicase and exonuclease cooperate to resolve telometric D-loops in a manner regulated by TRF1 and TRF2.
Molecular Cell.
Vitenskapelig artikkel
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Sharma, S;
Otterlei, Marit;
Sommers, JA;
Driscoll, HC;
Dianov, GL;
Kao, HI;
Bambara, RA;
Brosh, RM.
(2004)
WRN helicase and Flap endonuclease 1 forms a complex upon replication arrest and together process branch-migrating DNA structures associated with the replication fork.
Molecular Biology of the Cell.
volum 15 (2).
Vitenskapelig artikkel
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Baynton, Kathy;
Otterlei, Marit;
Bjørås, M.;
von Kobbe, Cayetano;
Bohr, Vilhelm;
Seeberg, E..
(2003)
WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*.
JBC Papers in Press.
volum 278 (38).
Vitenskapelig artikkel
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Bayton, Kathy;
Otterlei, Marit;
Bjørås, Magnar;
Kobbe, C von;
Bohr, V.A.;
Seeberg, Erling Christen.
(2003)
WRN interacts physically and functionally with the recombination mediator protein RAD52.
Journal of Biological Chemistry.
volum 278.
Vitenskapelig artikkel
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Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour;
Sundheim, Ottar;
Bjørås, Magnar;
Slupphaug, Geir;
Seeberg, Erling Christen;
Krokan, Hans Einar.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature.
volum 421.
Vitenskapelig artikkel
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Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank;
Aas, Per Arne;
Hagen, Lars;
Krokan, Hans Einar;
Slupphaug, Geir.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry.
volum 18.
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja;
Skjelbred, Camilla Furu;
Akbari, Mansour;
Aas, Per Arne;
Slupphaug, Geir.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology.
volum 68.
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, H.;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair in mammalian cells.
FEBS Letters.
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, Hilde;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair of DNA in mammalian cells.
FEBS Letters.
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR).
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR).
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal.
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal.
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde;
Skjelbred, Camilla;
Kavli, Bodil;
Standal, Rune;
Slupphaug, Geir.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences.
volum 302.
Vitenskapelig artikkel
-
Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour;
Aas, Per Arne;
Steinsbekk, Kristin;
Bakke, Oddmund;
Krokan, Hans Einar.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal.
volum 18 (13).
Vitenskapelig artikkel
-
Bharati, S.;
Krokan, Hans Einar;
Kristiansen, L;
Otterlei, Marit;
Slupphaug, Geir.
(1998)
Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
Nucleic Acids Research (NAR).
Vitenskapelig artikkel
-
Otterlei, Marit;
Haug, T.;
Nagelhus, T.A;
Slupphaug, Geir;
Lindmo, T.;
Krokan, Hans Einar.
(1998)
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively.
Nucleic Acids Research (NAR).
volum 26 (20).
Vitenskapelig artikkel
-
Nagelhus, T.;
Haug, T.;
Singh, K.K.;
Keshav, K.F.;
Skorpen, Frank;
Bharati, S.;
Otterlei, Marit;
Lindmo, T.;
Benichou, S.;
Benarous, R.;
Krokan, Hans Einar.
(1997)
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A.
Journal of Biological Chemistry.
Vitenskapelig artikkel
-
Nilsen, H.;
Otterlei, Marit;
Haug, T.;
Solum, K.;
Nagelhus, T.A;
Skorpen, Frank;
Krokan, Hans Einar.
(1997)
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
Nucleic Acids Research (NAR).
Vitenskapelig artikkel
Tidsskriftspublikasjoner
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Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Akbari, Mansour;
Otterlei, Marit.
(2012)
X-ray repair cross complementing protein 1 in base excision repair.
International Journal of Molecular Sciences.
volum 13 (12).
Vitenskapelig oversiktsartikkel/review
-
Otterlei, Marit;
Müller, R.;
Gilljam, Karin Margaretha;
Holien, Toril;
Midsund, K.;
Vatsveen, TK;
Ro, T.B.;
Bellacchio, E.;
Sundan, Anders.
(2012)
PEPTIDES COMPRISING THE NOVEL PCNA INTERACTING SEQUENCE APIM, INCREASES THE CYTOTOXICITY OF CHEMOTHERAPEUTIC DRUGS BY IMPAIRING THE CELLS DEFENSE MECHANISMS.
Annals of Oncology.
volum 23.
Sammendrag/abstract
-
Alevizopoulos, K;
Otterlei, Marit.
(2011)
ATX-101, a novel APIM-motif comprising peptide drug potentiates the action of several chemotherapeutic drugs by blocking the interaction between PCNA and key proteins involved in DNA repair and cell cycle control.
Annals of Oncology.
volum 22.
Sammendrag/abstract
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer.
volum 8 (5).
Sammendrag/abstract
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour;
Otterlei, Marit;
Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences.
volum 364 (1517).
Vitenskapelig oversiktsartikkel/review
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology.
volum 8 (6).
Vitenskapelig oversiktsartikkel/review
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Hagen, Lars;
Otterlei, Marit;
Gilljam, Karin Margaretha;
Slupphaug, Geir.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair.
Sammendrag/abstract
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research.
volum 312.
Vitenskapelig oversiktsartikkel/review
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene;
Aarset, Harald;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal.
volum 273.
Sammendrag/abstract
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud;
Diaz, Javier Pena;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair.
volum 3 (11).
Vitenskapelig oversiktsartikkel/review
Bøker
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde;
Nagelhus-Hernes, T;
Haug, T;
Aas, Per A;
Akbari, M;
Skjelbred, Camilla;
Kavli, Bodil.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
1998. DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences..
Fagbok
Del av bok/rapport
-
Krokan, Hans Einar;
Standal, Rune;
Bharati, Sangeeta;
Otterlei, Marit;
Haug, Terje;
Slupphaug, Geir;
Skorpen, Frank.
(1997)
Uracil in DNA and the family of concerved uracil DNA glycosylases.
Base excision repair on DNA damage.
Vitenskapelig kapittel/artikkel
Rapport
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Mekanismer for intracellulær sortering av UNG-proteiner studert ved molekylærbiologiske og biofysiske metoder.
1998.
Rapport
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Sekvenser i UNG2 som er viktige for UDG-aktivitet, Mg2eion stimulering og intracellulær sortering.
1998.
Rapport
-
Jørgensen, Kjersti;
Otterlei, Marit.
(1998)
Human uracil DNA glycosylase. Egenskaper til enzymer med og uten presekvens.
1998.
Hovedfagsoppgave
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Skjåk-Bræk, Gudmund;
Espevik, Terje;
Otterlei, Marit;
Smidsrød, Olav;
Soon-Shiong, P..
(1995)
Homologous guluronic acid alginate coating composition for in vivo application and implantation and method using the same.
1995. US-Patent 5459 054, Oct. 1995.
Rapport
Undervisning
Emner
Formidling
2019
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PosterRøst, Lisa Marie; Løkken, Erle Gustavsen; Otterlei, Marit; Bruheim, Per. (2019) Glioblastoma cells respond to hypoxia by increased cell growth and altered TCA-cycle progression. NBS Vintermøte . Norsk Biokjemisk Selskap Trondheim; Røros. 2019-01-24 - 2019-01-27.
2018
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PosterKim, Jana; Søgaard, Caroline Krogh; Kim, Eugene; Bathen, Tone Frost; Otterlei, Marit; Moestue, Siver Andreas; Hill, Deborah Katherine. (2018) Diffusion weighted MRI simplifies therapy monitoring in TRAMP mice. Joint Annual Meeting ISMRM-ESMRMB ; Paris. 2018-06-16 - 2018-06-21.
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PosterOlaisen, Camilla; Røst, Lisa Marie; Nedal, Aina; Petrovic, Voin; Kvitvang, Hans Fredrik Nyvold; Bruheim, Per; Otterlei, Marit. (2018) Proliferating Cell Nuclear Antigen (PCNA) has a Central Role in Regulation of the Glycolysis in Haematological Cancer Cells. Metabolism and Cancer . American Association of Cancer Research; Marriott New York Brooklyn Bridge. 2018-09-28 - 2018-10-01.
2016
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PosterRøst, Lisa Marie; Olaisen, Camilla; Petrovic, Voin; Otterlei, Marit; Bruheim, Per. (2016) Blocking the Stress-specific APIM-PCNA Interaction in Multiple Myeloma Cells Cause Significant Changes in Central Carbon Metabolism. ISCaM 2016: Metabolic Networks in Cancer . International Society of Cancer Metabolism; Brussel. 2016-10-26 - 2016-10-29.
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PosterSøgaard, Caroline Danielsen; Petrovic, Voin; Blindheim, Augun; Gederaas, Odrun Arna; Arum, Carl-Jørgen; Otterlei, Marit. (2016) PCNA-targeting APIM-peptide alters response to DNA damage in human bladder cancer cells on a signaling level. 2nd EMBO Cellular Signalling & Cancer Therapy Conference . EMBO; Cavtat. 2016-05-27 - 2016-05-31.
2012
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PosterArum, Carl-Jørgen; Gederaas, Odrun; Bachke, Siri; Viset, Trond; Otterlei, Marit. (2012) Targeting DNA repair mechanisms increases efficiency of intravesical chemotherapy in an orthotopic rat bladder model. info kommer . EAU, AUA; info kommer. 2012-11-30 - 2012-11-30.
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PosterBaglo, Yan; Müller, Rebekka; Otterlei, Marit; Gederaas, Odrun Arna. (2012) Analysis of stress responses induced by hexylaminolevulinate-mediated photodynamic treatment. NBS winter meeting 2012 . Norsk Biokjemisk Selskap; Storfjell, Gol. 2012-01-19 - 2012-01-22.
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Vitenskapelig foredragGederaas, Odrun; Bachke, Siri; Sørgaard, Caroline Danielsen; Viset, Trond; Arum, Carl-Jørgen; Otterlei, Marit. (2012) Increased efficacy of intravesical chemotherapy in an orthotopic rat bladder cancer model by targeting PCNA with the novel synthetic peptide drug ATX-101. Congress, USA. Urology (korrekt navn blir supplert) ; 2012-11-30 - 2012-11-30.
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Vitenskapelig foredragOtterlei, Marit. (2012) APIM-peptides targeting PCNA induce apoptosis in cancer cells. The 3rd Erling Seeberg Symposium on DNA Repair ; Trondheim. 2012-07-19 - 2012-07-23.
2011
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PosterBaglo, Yan; Müller, Rebekka; Otterlei, Marit; Gederaas, Odrun Arna. (2011) Analysis of stress responses induced by hexylaminolevulinate-mediated photodynamic treatment. 14th Congress of the European Society for Photobiology . University of Geneva and ESP; Geneva. 2011-09-01 - 2011-09-06.
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Vitenskapelig foredragMüller, Rebekka; Giljam, Karin Margaretha; Liabakk, Nina-Beate; Otterlei, Marit. (2011) Efficient repair of UV-induced DNA damage during replication depends on direct XPA-PCNA interaction. Eukaryotic DNA Replication & Genome Maintenance . Cold Spring Harbor Laboratory; Cold Spring Harbor. 2011-09-06 - 2011-09-10.
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PosterMüller, Rebekka; Jacob, Havjin; Bachke, Siri; Giljam, Karin Margaretha; Otterlei, Marit. (2011) Inhibition of the NF-kappaB pathway by the APIM-peptide. Responses to DNA damage: from molecular mechanism to human disease ; Egmond aan Zee. 2011-04-03 - 2011-04-08.
2010
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. 6th Norwegian National Proteomics Meeting . NTNU; trondheim. 2010-12-09 - 2010-12-10.
2009
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PosterBruheim, Per; Sletta, Håvard; Klinkenberg, Geir; Ellingsen, Trond Erling; Krokan, Hans Einar; Otterlei, Marit. (2009) Systems biology and high resolution genome-wide phenotyping of yeast used for identification of cellular and molecular effects of DNA damaging agents. 3rd US-EU Workshop "Systems level understanding of DNA damage responses" ; Egmond aan Zee. 2009-03-30 - 2009-04-01.
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka; Catterall, Tara C; Vågbø, Cathrine Broberg; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn; Krokan, Hans Einar; Otterlei, Marit. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. 2nd Erling Seeberg Symposium on DNA Repair . Rikshospitalet-Radiumhospitalet og Universitetet i Oslo; 2009-06-20 - 2009-06-25.
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Vitenskapelig foredragKrokan, Hans Einar; Visnes, Torkild; Doseth, Berit; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir. (2009) Uracil in DNA and its processing. 3rd US-EU Conference- Repair of Endogenous Genome Damage . E. Dogliotti, H. Krokan, T. Stevnsner, S. Mitra, S.H. Wilson; Moody Gardens Hotel, Galveston, Texas. 2009-02-21 - 2009-02-25.
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Vitenskapelig foredragOtterlei, Marit. (2009) A New PCNA Binding Motif which Sensitizes Cancer Cells to Chemotherapy. Symposium on trends and needs in medical technology and health care . NTNU; 2009-11-05 - 2009-11-06.
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Vitenskapelig foredragOtterlei, Marit. (2009) A new PCNA binding motif with possible implication in chemotherapy. Torsdagseminar, IMBV, UiO . Inger Sandlie, UiO; UiO. 2009-09-03.
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Vitenskapelig foredragOtterlei, Marit. (2009) APIM Therapeutics, improving chemotherapy for cancer patients. Selbu møte 2009 . Norsk Biokjemisk Selskap avd. Midt Norge; 2009-10-05 - 2009-10-06.
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Populærvitenskapelig foredragOtterlei, Marit. (2009) GFP, the "Nobel" protein. Medlemsmøte NKS . Norsk Kjemisk Selskap, NTNU; 2009-02-10.
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Vitenskapelig foredragOtterlei, Marit. (2009) Identification of a novel and widespread PCNA interacting motif with potential use in chemotherapy. Tirsdagseminar, IBT, NTNU ; IBT, NTNU. 2009-11-25.
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PosterPsonka-Antonczyk, Katarzyna Maria; Akbari, Mansour; Otterlei, Marit; Krokan, Hans Einar; Stokke, Bjørn Torger. (2009) Uracil-DNA glycosylase (UNG) interacting with mismatched DNA – a single molecule approach. European Biophysics Congress . European Biophysical Societies' Association; Genoa. 2009-07-11 - 2009-07-15.
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Vitenskapelig foredragSlupphaug, Geir; Doseth, Berit; Kavli, Bodil Merete; Visnes, Torkild; Hagen, Lars; Torseth, Kathrin; Pettersen, Henrik Sahlin; Akbari, Mansour; Otterlei, Marit; Krokan, Hans Einar. (2009) Genomic uracil processing in mice and men. 2.nd Erling Seeberg symposium on DNA repair ; Ålesund/Geiranger. 2009-06-20 - 2009-06-25.
2008
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Vitenskapelig foredragSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate; Otterlei, Marit; Krokan, Hans Einar. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance ; St. Petersburg. 2008-06-24 - 2008-06-26.
2007
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Vitenskapelig foredragSæten, Christina; Misund, Kristine; Steigedal, Tonje; Otterlei, Marit; Lægreid, Astrid; Thommesen, Liv; Bruland, Torunn. (2007) Complex functional studies in mammalian cells using transfected cell arrays. The Norwegian Bichemical Society 43. Contact Meeting . Norsk Biokjemisk Selskap (NBS); Lillehammer. 2007-02-01 - 2007-02-04.
2006
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PosterHagen, Lars; Kavli, Bodil Merete; Sundheim, Ottar; Sousa, Mirta; Otterlei, Marit; Liabakk, Nina-Beate; Torseth, Kathrin; Krokan, Hans Einar; Slupphaug, Geir. (2006) Regulation of uracil base excision repair by post-translational modifications. Erling Seeberg Symposium on DNA Repair ; 2006-05-28 - 2006-06-02.
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PosterHanssen-Bauer, Audun; Solvang-Garten, Karin; Akbari, Mansour; Krokan, Hans Einar; Otterlei, Marit. (2006) Functional analysis of XRCC1 associated repair complexes containing the XRCC1 polymorphisms Arg194Trp, Arg280His, and Arg399Gln. DNA repair: from Molecular Mechanism to Human Disease . EU IP "DNA Damage Response and Repair Mechanisms"; Noordwijkerhout. 2006-04-02 - 2006-04-07.
2005
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PosterBruland, Torunn; Sæten, Christina; Strømmen, Tonje; Bergum, Hallgeir; Otterlei, Marit; Thommesen, Liv; Lægreid, Astrid. (2005) High-throughput characterisation of gene function using cell microarray. The2nd ESF Functional Genomic Conference, Oslo . ESF; Oslo. 2005-09-06 - 2005-09-10.
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PosterDiaz, Javier Pena; Hegre, Siv Anita; Akbari, Mansour; Sousa, Mirta; Sundheim, Ottar; Hanssen-Bauer, Audun; Slupphaug, Geir; Krokan, Hans Einar; Otterlei, Marit. (2005) Recruitment of the chaperone Hsp70 to Base Excision Repair complexes. 2nd EU-US DNA RepairMeeting ; 2005-11-29 - 2005-12-03.
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PosterKavli, Bodil Merete; Diaz, Javier Pena; Otterlei, Marit; Liabakk, Nina-Beate; Giljam, Karin Margaretha; Krokan, Hans Einar; Hørning, Ole; Jensen, Ole N; Slupphaug, Geir; Hagen, Lars. (2005) The enzymatic activity of human uracil-DNA glycosylase UNG2 is regulated by N-terminal phosphorylation during cell cycle. 2nd EU-US DNA Repair Meeting: Endogeneous Stress, Base excision repair and related processes . Instituto Superiore di Sanita/EMBO; Erice, Sicily. 2005-11-28 - 2005-12-03.
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PosterOtterlei, Marit; Akbari, Mansour; Hanssen-Bauer, Audun; Garten, Karin; Wilson III, David; Andersen, Sonja Benedikte; Krokan, Hans Einar. (2005) Base Excision Repair and Single Strand Break Repair proficient XRCC1 complexes. DNA repair meeting ; Sicily. 2005-11-28 - 2005-12-03.
2004
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PosterAkbari, Mansour; Monterotti, Bruno; Krokan, Hans Einar; Otterlei, Marit. (2004) XRCC1-Associated repair complexes (ARC). DNA-repair and mutagenesis: From molecular structure to biological consequences ; 2004-11-14 - 2004-11-20.
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Vitenskapelig foredragBruland, Torunn; Bergum, Hallgeir; Steigedal, Tonje; Otterlei, Marit; Thommesen, Liv; Lægreid, Astrid. (2004) Array based screening og gene function and cell-biological application of transfected-cell microarrays. NBS Kontaktmøte . NBS; Hafjell. 2004-01-15 - 2004-01-18.
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PosterKavli, Bodil; Otterlei, Marit; Liabakk, Nina-Beate; Krokan, Hans Einar; Slupphaug, Geir. (2004) The mutant UNG2-F-25 1S associated with HIGM syndrome is abnormally translocated and degraded, and results in impaired nuclear uracil excision and accumulation of genomic uracil. ASM Conference on DNA Repair and Mutagenesis ; Bermuda. 2004-11-14 - 2004-11-20.
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PosterOtterlei, Marit. (2004) Biochemical and Genetic Characterization og the interaction between Werner Syndrome protein and Fen-1 suggests their mechanism of action in vivo. DNA Repair and mutagenesis: From molecular structure to biological consequences ; 2004-11-14 - 2004-11-20.
2003
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PosterLuna, Luisa; Rolseth, Veslemøy; Otterlei, Marit; Hildestrand, Gunn; Seeberg, Erling Christen. (2003) Subnuclear localisation of hOgg1 in dependent on phosphorylation of serine 36 and is disrupted in the polymorphic hOgg1-Cys326 allele. Vintermøte . The Norwegian Biochemical Society; Geilo. 2003-01-23 - 2003-01-26.
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Populærvitenskapelig foredragOtterlei, Marit. (2003) Involvement of WRN in homologous recombination. [Mangler data] . "Tirsdagsmøte"; Trondheim, Norge. 2003-09-30.
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Vitenskapelig foredragOtterlei, Marit; Bruheim, Per; Byungchan, Ahn; Baynton, Kathy; Opresko, Patricia; Seeberg, E.; Sung, Patrick; Bohr, Vilhelm. (2003) DNA damage causing replication arrest leads to a relocation of WRN hekicase to complexes containing proteins from the RAD52 epistasis group: RAD52, RAD51, RAD54 and RAD54B. Possible role for WRN in regulation of HR. International Workshop on Werner Syndrome . [Mangler data]; Lansdowne. 2003-05-31.
2002
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Vitenskapelig foredragAas, Per Arne; Otterlei, Marit; Skorpen, Frank; Akbari, Mansour; Slupphaug, Geir; Krokan, Hans Einar. (2002) Repair of alkylated single-stranded DNA and RNA in living cells. 38.Biokjemiske kontaktmøte Functional genomics-the mosaics of life . [Mangler data]; Røros. 2002-01-20.
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PosterKavli, Bodil; Otterlei, Marit; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Krokan, Hans Einar; Slupphaug, Geir. (2002)