Gøril Rolfseng Grøntvedt
Gøril Rolfseng Grøntvedt
Førsteamanuensis og ko-direktør NDS/ Avdelingssjef
goril.r.grontvedt@ntnu.no
Om
Avdelingssjef, avdeling for nevrologi og klinisk nevrofysiologi, St Olavs Hospital. Som overlege jobber jeg først og fremst med nevrodegenerative sykdommer/Alzheimers sykdom og utredning av pasienter med mistenkt kognitiv svikt.
Førsteamanuensis ved INB og ko-direktør ved Nasjonalforeningens Demensforskningssenter, Kavli-intistuttet, NTNU.
Seniorforsker i Trønderbrain.
Pasientrekruttering er en grunnpilar i translasjonsforskningen i NDS og styrkes gjennom samarbeid med Trønderbrain-prosjektet. Trønderbrain har en veldefinert pasientkohort som består av pasienter med AD og andre demensformer, personer med preklinisk AD og friske kontroller. Forskningen har som mål å å identifisere tilgjengelige, presise og kostnadseffektive biomarkører for tidlig diagnostikk og å identifisere potensielle beskyttende faktorer mot nevrodegenerasjon.
Forskning
Forskningsfokuset til Trønderbrain er å fostå molekylære prosesser som starter og fører til progresjon av nevrodegenerative sykdommer med spesielt fokus på Alzheimers sykdom.
Målet er å identifisere nye biomarkører som kan bidra til tidlig diagnose, forståelse av sykdomsprosesser og å finne mål for effektiv terapi.
Gruppen består av forskere og klinikere som sammen kan bygge bro mellom grunnleggende forskning i celle-og dyremodeller og klinisk forskning på mennesker.
Publikasjoner
2025
-
Richter, Grit;
Kirsebom, Bjørn-Eivind;
Jarholm, Jonas Alexander;
Pålhaugen, Lene;
Gisladottir, Berglind;
Aarsland, Dag.
(2025)
Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes.
Neurobiology of Aging
Vitenskapelig artikkel
-
Hemminghyth, Mathilde Suhr;
Breitve, Monica Haraldseid;
Chwiszczuk, Luiza;
Gísladóttir, Berglind;
Hessen, Erik;
Siafarikas, Nikias Ioannis.
(2025)
Demographically unadjusted cognitive test scores may enhance the validity of mild cognitive impairment as a dementia prodrome.
Applied neuropsychology: Adult
Vitenskapelig artikkel
2024
-
Hemminghyth, Mathilde Suhr;
Chwiszczuk, Luiza;
Breitve, Monica Haraldseid;
Gisladottir, Berglind;
Grøntvedt, Gøril Rolfseng;
Nakling, Arne Exner.
(2024)
Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults.
Neurobiology of Aging
Vitenskapelig artikkel
-
Swift, Imogen J.;
Rademakers, Rosa;
Finch, NiCole;
Baker, Matt;
Ghidoni, Roberta;
Benussi, Luisa.
(2024)
A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Gonzalez-Ortiz, Fernando;
Kirsebom, Bjørn-Eivind Seljelid;
Contador, José;
Tanley, Jordan E.;
Selnes, Per;
Gisladottir, Berglind.
(2024)
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease.
Nature Communications
Vitenskapelig artikkel
-
Knudtzon, Stephanie;
Nordengen, Kaja;
Grøntvedt, Gøril Rolfseng;
Jarholm, Jonas Alexander;
Eliassen, Ingvild Vøllo;
Selnes, Per.
(2024)
Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer’s Disease.
Neurobiology of Aging
Vitenskapelig artikkel
-
Egiazarian, Milena Armenovna;
Abentung, Andreas;
Sakshaug, Teri;
Karabeika, Emily;
Hanumaihgari, Priyanka Reddy;
Grøntvedt, Gøril Rolfseng.
(2024)
The role of impaired oxidative base lesion repair in Alzheimer’s disease.
Alzheimer's & Dementia
Sammendrag/Abstract
2023
-
Nordengen, Kaja;
Kirsebom, Bjørn-Eivind Seljelid;
Richter, Grit;
Pålhaugen, Lene;
Gisladottir, Berglind;
Siafarikas, Nikias Ioannis.
(2023)
Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease.
Journal of Neuroinflammation
Vitenskapelig artikkel
-
Bøen, Rune;
Kaufmann, Tobias Herbert;
Meer, Dennis van der;
Frei, Oleksandr;
Agartz, Ingrid;
Ames, David.
(2023)
Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers.
Biological Psychiatry
Vitenskapelig artikkel
-
Jarholm, Jonas Alexander;
Bjørnerud, Atle;
Dalaker, Turi Olene;
Akhavi, Mehdi Sadat;
Kirsebom, Bjørn-Eivind;
Pålhaugen, Lene.
(2023)
Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
2022
-
Giannisis, Andreas;
Al-Grety, Asma;
Carlsson, Henrik;
Patra, Kalicharan;
Twohig, Daniel;
Sando, Sigrid Botne.
(2022)
Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Bråthen, Geir;
White, Linda Rosemary;
Salvesen, Øyvind.
(2022)
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden.
JAMA Network Open
Vitenskapelig artikkel
2021
-
Lim, Bryant;
Grøntvedt, Gøril Rolfseng;
Bathala, Pradeepthi;
Kale, Shraddha S.;
Campbell, Christopher T.;
Stengelin, Martin.
(2021)
CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia.
Neurobiology of Aging
Vitenskapelig artikkel
2020
-
Lim, Bryant;
Sando, Sigrid Botne;
Grøntvedt, Gøril Rolfseng;
Bråthen, Geir;
Diamandis, Eleftherios P..
(2020)
Cerebrospinal fluid neuronal pentraxin receptor as a biomarker of long-term progression of Alzheimer's disease: a 24-month follow-up study.
Neurobiology of Aging
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Lauridsen, Camilla;
Berge, Guro;
White, Linda Rosemary;
Salvesen, Øyvind;
Bråthen, Geir.
(2020)
The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
2019
-
Patra, Kalicharan;
Giannisis, Andreas;
Edlund, Anna K.;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Berge, Guro.
(2019)
Plasma apolipoprotein E monomer and dimer profile and relevance to Alzheimer's disease.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Kirsebom, Bjørn-Eivind;
Espenes, Ragna;
Hessen, Erik;
Waterloo, Knut;
Johnsen, Stein Harald;
Gundersen, Elisabeth.
(2019)
Demographically adjusted CERAD wordlist test norms in a Norwegian sample from 40 to 80 years.
The Clinical Neuropsychologist
Vitenskapelig artikkel
-
Nordengen, Kaja;
Kirsebom, Bjørn-Eivind;
Henjum, Kristi;
Selnes, Per;
Gisladottir, Berglind;
Wettergreen, Marianne.
(2019)
Glial activation and inflammation along the Alzheimer's disease continuum.
Journal of Neuroinflammation
Vitenskapelig artikkel
2018
-
Patra, Kalicharan;
Soosaipillai, Antoninus;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Berge, Guro;
Møller, Ina.
(2018)
Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Schröder, Tobias Navarro;
Sando, Sigrid Botne;
Bråthen, Geir;
White, Linda Rosemary;
Doeller, Christian Fritz Andreas.
(2018)
Alzheimer´s disease.
Current Biology
Populærvitenskapelig artikkel
-
Twohig, Daniel;
Rodriguez-Vieitez, Elena;
Sando, Sigrid Botne;
Berge, Guro;
Lauridsen, Camilla;
Møller, Ina.
(2018)
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.
Acta neuropathologica communications
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Schröder, Tobias Navarro;
Sando, Sigrid Botne;
White, Linda Rosemary;
Bråthen, Geir;
Doeller, Christian.
(2018)
Alzheimer's disease.
Current Biology
Populærvitenskapelig artikkel
2017
-
Fladby, Tormod;
Pålhaugen, Lene;
Selnes, Per;
Waterloo, Knut;
Bråthen, Geir;
Hessen, Erik.
(2017)
Detecting at-risk Alzheimer's disease cases.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Lauridsen, Camilla;
Sando, Sigrid Botne;
Møller, Ina;
Berge, Guro;
Pomary, Precious Kwadzo;
Grøntvedt, Gøril Rolfseng.
(2017)
Cerebrospinal fluid Aβ43 is reduced in early-onset compared to late-onset Alzheimer's disease, but has similar diagnostic accuracy to Aβ42.
Frontiers in Aging Neuroscience
Vitenskapelig artikkel
2016
-
Berge, Guro;
Sando, Sigrid Botne;
Albrektsen, Grethe;
Lauridsen, Camilla;
Møller, Ina;
Grøntvedt, Gøril Rolfseng.
(2016)
Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer's disease, mild cognitive impairment, or healthy controls: a two year follow-up study.
BMC Neurology
Vitenskapelig artikkel
-
Lauridsen, Camilla;
Sando, Sigrid Botne;
Shabnam, Adiba;
Møller, Ina;
Berge, Guro;
Grøntvedt, Gøril Rolfseng.
(2016)
Cerebrospinal Fluid Levels of Amyloid Beta 1-43 in Patients with Amnestic Mild Cognitive Impairment or Early Alzheimer's Disease: A 2-Year Follow-Up Study.
Frontiers in Aging Neuroscience
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Richter, Grit;
Kirsebom, Bjørn-Eivind;
Jarholm, Jonas Alexander;
Pålhaugen, Lene;
Gisladottir, Berglind;
Aarsland, Dag.
(2025)
Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes.
Neurobiology of Aging
Vitenskapelig artikkel
-
Hemminghyth, Mathilde Suhr;
Breitve, Monica Haraldseid;
Chwiszczuk, Luiza;
Gísladóttir, Berglind;
Hessen, Erik;
Siafarikas, Nikias Ioannis.
(2025)
Demographically unadjusted cognitive test scores may enhance the validity of mild cognitive impairment as a dementia prodrome.
Applied neuropsychology: Adult
Vitenskapelig artikkel
-
Hemminghyth, Mathilde Suhr;
Chwiszczuk, Luiza;
Breitve, Monica Haraldseid;
Gisladottir, Berglind;
Grøntvedt, Gøril Rolfseng;
Nakling, Arne Exner.
(2024)
Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults.
Neurobiology of Aging
Vitenskapelig artikkel
-
Swift, Imogen J.;
Rademakers, Rosa;
Finch, NiCole;
Baker, Matt;
Ghidoni, Roberta;
Benussi, Luisa.
(2024)
A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Gonzalez-Ortiz, Fernando;
Kirsebom, Bjørn-Eivind Seljelid;
Contador, José;
Tanley, Jordan E.;
Selnes, Per;
Gisladottir, Berglind.
(2024)
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease.
Nature Communications
Vitenskapelig artikkel
-
Knudtzon, Stephanie;
Nordengen, Kaja;
Grøntvedt, Gøril Rolfseng;
Jarholm, Jonas Alexander;
Eliassen, Ingvild Vøllo;
Selnes, Per.
(2024)
Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer’s Disease.
Neurobiology of Aging
Vitenskapelig artikkel
-
Egiazarian, Milena Armenovna;
Abentung, Andreas;
Sakshaug, Teri;
Karabeika, Emily;
Hanumaihgari, Priyanka Reddy;
Grøntvedt, Gøril Rolfseng.
(2024)
The role of impaired oxidative base lesion repair in Alzheimer’s disease.
Alzheimer's & Dementia
Sammendrag/Abstract
-
Nordengen, Kaja;
Kirsebom, Bjørn-Eivind Seljelid;
Richter, Grit;
Pålhaugen, Lene;
Gisladottir, Berglind;
Siafarikas, Nikias Ioannis.
(2023)
Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease.
Journal of Neuroinflammation
Vitenskapelig artikkel
-
Bøen, Rune;
Kaufmann, Tobias Herbert;
Meer, Dennis van der;
Frei, Oleksandr;
Agartz, Ingrid;
Ames, David.
(2023)
Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers.
Biological Psychiatry
Vitenskapelig artikkel
-
Jarholm, Jonas Alexander;
Bjørnerud, Atle;
Dalaker, Turi Olene;
Akhavi, Mehdi Sadat;
Kirsebom, Bjørn-Eivind;
Pålhaugen, Lene.
(2023)
Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Giannisis, Andreas;
Al-Grety, Asma;
Carlsson, Henrik;
Patra, Kalicharan;
Twohig, Daniel;
Sando, Sigrid Botne.
(2022)
Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Bråthen, Geir;
White, Linda Rosemary;
Salvesen, Øyvind.
(2022)
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden.
JAMA Network Open
Vitenskapelig artikkel
-
Lim, Bryant;
Grøntvedt, Gøril Rolfseng;
Bathala, Pradeepthi;
Kale, Shraddha S.;
Campbell, Christopher T.;
Stengelin, Martin.
(2021)
CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia.
Neurobiology of Aging
Vitenskapelig artikkel
-
Lim, Bryant;
Sando, Sigrid Botne;
Grøntvedt, Gøril Rolfseng;
Bråthen, Geir;
Diamandis, Eleftherios P..
(2020)
Cerebrospinal fluid neuronal pentraxin receptor as a biomarker of long-term progression of Alzheimer's disease: a 24-month follow-up study.
Neurobiology of Aging
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Lauridsen, Camilla;
Berge, Guro;
White, Linda Rosemary;
Salvesen, Øyvind;
Bråthen, Geir.
(2020)
The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Patra, Kalicharan;
Giannisis, Andreas;
Edlund, Anna K.;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Berge, Guro.
(2019)
Plasma apolipoprotein E monomer and dimer profile and relevance to Alzheimer's disease.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Kirsebom, Bjørn-Eivind;
Espenes, Ragna;
Hessen, Erik;
Waterloo, Knut;
Johnsen, Stein Harald;
Gundersen, Elisabeth.
(2019)
Demographically adjusted CERAD wordlist test norms in a Norwegian sample from 40 to 80 years.
The Clinical Neuropsychologist
Vitenskapelig artikkel
-
Nordengen, Kaja;
Kirsebom, Bjørn-Eivind;
Henjum, Kristi;
Selnes, Per;
Gisladottir, Berglind;
Wettergreen, Marianne.
(2019)
Glial activation and inflammation along the Alzheimer's disease continuum.
Journal of Neuroinflammation
Vitenskapelig artikkel
-
Patra, Kalicharan;
Soosaipillai, Antoninus;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Berge, Guro;
Møller, Ina.
(2018)
Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease.
Alzheimer's Research & Therapy
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Schröder, Tobias Navarro;
Sando, Sigrid Botne;
Bråthen, Geir;
White, Linda Rosemary;
Doeller, Christian Fritz Andreas.
(2018)
Alzheimer´s disease.
Current Biology
Populærvitenskapelig artikkel
-
Twohig, Daniel;
Rodriguez-Vieitez, Elena;
Sando, Sigrid Botne;
Berge, Guro;
Lauridsen, Camilla;
Møller, Ina.
(2018)
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.
Acta neuropathologica communications
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Schröder, Tobias Navarro;
Sando, Sigrid Botne;
White, Linda Rosemary;
Bråthen, Geir;
Doeller, Christian.
(2018)
Alzheimer's disease.
Current Biology
Populærvitenskapelig artikkel
-
Fladby, Tormod;
Pålhaugen, Lene;
Selnes, Per;
Waterloo, Knut;
Bråthen, Geir;
Hessen, Erik.
(2017)
Detecting at-risk Alzheimer's disease cases.
Journal of Alzheimer's Disease
Vitenskapelig artikkel
-
Lauridsen, Camilla;
Sando, Sigrid Botne;
Møller, Ina;
Berge, Guro;
Pomary, Precious Kwadzo;
Grøntvedt, Gøril Rolfseng.
(2017)
Cerebrospinal fluid Aβ43 is reduced in early-onset compared to late-onset Alzheimer's disease, but has similar diagnostic accuracy to Aβ42.
Frontiers in Aging Neuroscience
Vitenskapelig artikkel
-
Berge, Guro;
Sando, Sigrid Botne;
Albrektsen, Grethe;
Lauridsen, Camilla;
Møller, Ina;
Grøntvedt, Gøril Rolfseng.
(2016)
Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer's disease, mild cognitive impairment, or healthy controls: a two year follow-up study.
BMC Neurology
Vitenskapelig artikkel
-
Lauridsen, Camilla;
Sando, Sigrid Botne;
Shabnam, Adiba;
Møller, Ina;
Berge, Guro;
Grøntvedt, Gøril Rolfseng.
(2016)
Cerebrospinal Fluid Levels of Amyloid Beta 1-43 in Patients with Amnestic Mild Cognitive Impairment or Early Alzheimer's Disease: A 2-Year Follow-Up Study.
Frontiers in Aging Neuroscience
Vitenskapelig artikkel
Formidling
Podcast Diagnose Alzheimers sykdom
Hva er det som skjer med hjernen når vi får Alzheimers sykdom? Og hvordan må vi forske om vi skal finne en kur?
Ta vare på hjernen
Hvordan utvikler hjernen seg og hva fremmer en sunn hjerne? Hva skjer i hjernen ved sykdom og hva kan du selv gjøre for å ta vare på din psykiske helse?
Adressasamtalen
Adressasamtalen 2023 om demens
2024
-
PosterEgiazarian, Milena Armenovna; Abentung, Andreas; Karabeika, Emily; Hanumaihgari, Priyanka; Schnur, Paulina; Hovland, Oline Øie. (2024) The role of impaired oxidative base lesion repair in Alzheimer's disease. Alzheimer's Association International Conference 2024-07-28 - 2024-08-01
2023
-
PosterHemminghyth, Mathilde Suhr; Breitve, Monica Haraldseid; Gisladottir, Berglind; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Fladby, Tormod. (2023) Cerebrospinal fluid neurofilament light chain mediates age-related decline in learning and memory in healthy adults. Alzheimer's Association International Conference , Amsterdam 2023-07-14 - 2023-07-20
2022
-
PosterBecu, Marcia Constance Noemi; Bonnevie, Tora; Polti, Ignacio; Jarholm, Jonas Alexander; Grøntvedt, Gøril Rolfseng; Bråthen, Geir. (2022) Entorhinal grid-like representation in early Alzheimer's disease: association with biomarkers concentration and genetic risk. Society for Neuroscience 2022 2022-11-12 - 2022-11-12
2017
-
PosterLauridsen, Camilla; Sando, Sigrid Botne; Møller, Ina; Berge, Guro; Pomary, Precious Kwadzo; Grøntvedt, Gøril Rolfseng. (2017) Cerebrospinal fluid levels of Aβ43 are significantly decreased in patients with early-onset compared to late-onset Alzheimer’s disease. The 13th International Conference on Alzheimer's and Parkinson's Diseases (ADPD) , Wien 2017-03-29 - 2017-04-02