Cathrine Broberg Vågbø
Om
Jeg har doktorgrad innen molekylærmedisin og er ansatt ved Proteomics and Modomics Experimental Core facility (PROMEC), Institutt for klinisk og molekylær medisin, NTNU.
Mitt spesialområde er RNA-epitranskriptomikk og DNA-epigenetikk som sammen regulerer genuttrykket og gjennom det de fleste cellulære prosesser. Mitt hovedmål er å bidra til økt kunnskap om hvordan feil i disse systemene forårsaker sykdom. Jeg har 20 års erfaring med analytiske teknikker som kromatografi og massespektrometri, og utvikling av metoder for å karakterisere kjemiske RNA- og DNA-modifikasjoner har stått sentralt i arbeidet mitt. I dag er disse metodene en del av PROMEC-repertoaret hvor de brukes av en rekke forskningsgrupper nasjonalt og internasjonalt.
Publikasjoner
Publisert 41 artikler (PubMed) i fagfellevurderte internasjonale tidsskrift, >5000 siteringer, h-index 27 (Publons).
Statistikk: Journal (impact factor, antall publikasjoner): Nature (69.5, 3), Cell (41.6, 1), Nat Neurosci (28.1, 1), Mol Cell (19.3, 2), Nucleic Acids Res (19.1, 6), Sci Adv (14.1, 1), Genes&Dev (12.9, 2), Nat Commun (17.7, 2), EMBO J (13.8, 2), Am J Hum Genet (11.0, 1), Cell Rep (10.0, 2), J Cell Biol (8.1, 1), Oncotarget (6.0, 1), J Transl Med (5.5, 1), Epigenet Chromatin (5.2, 1), DNA Rep (4.9, 5), J Biol Chem (4.6, 1), Cell Discov (4.5, 1), Sci Rep (4.5, 1), Mol Cell Biol (4.4, 1), Hum Genet (5.2, 1), PlosOne (3.5, 1), J Pharmacol Exp Ther (3.0, 1), F1000Res (1.7, 1), J Clin Pharm (1.7, 1).
Forfattet lærebokkapittel: Genomic Uracil: Evolution, Biology, Immunology and Disease, ISBN 9813233494, World Scientific publishing (2018).
Publikasjoner
2024
-
Schwarz, Simon D.;
Xu, Jianming;
Gunasekera, Kapila;
Schürmann, David;
Vågbø, Cathrine Broberg;
Ferrari, Elena.
(2024)
Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation.
Nature Communications
Vitenskapelig artikkel
2023
-
Dohnalkova, Michaela;
Krasnykov, Kyrylo;
Mendel, Mateusz;
Li, Lingyun;
Panasenko, Olesya;
Fleury-Olela, Fabienne.
(2023)
Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility.
Cell reports
Vitenskapelig artikkel
-
Sherwood, Anna V.;
Rivera-Rangel, Lizandro R.;
Ryberg, Line A.;
Larsen, Helena S.;
Anker, Klara M.;
Costa, Rui.
(2023)
Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide.
Nature
Vitenskapelig artikkel
-
Hayran , Abdul Baset ;
Liabakk, Nina-Beate;
Aas, Per Arne;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Sarno, Antonio.
(2023)
RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2022
-
Emdal, Elisabeth Fritzke;
Ottestad, Anine Larsen;
Vågbø, Cathrine Broberg;
Skarpeteig, Veronica ;
Rye, Morten Beck.
(2022)
Prøv deg som en DNA-detektiv.
Forskningstorget 2022
Annen presentasjon
-
Eftedal, Ingrid;
Vågbø, Cathrine Broberg;
Lund, Hedda Juni.
(2022)
Quantification of guanine-derived urinary biomarkers of oxidative stress in saturation divers by LC-MS/MS.
Norges Teknisk Naturvitenskaplige Universitet
Mastergradsoppgave
2021
-
Mendel, Mateusz;
Delaney, Kamila;
Pandey, Radha Raman;
Chen, Kuan-Ming;
Wenda, Joanna M.;
Vågbø, Cathrine Broberg.
(2021)
Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Cell
Vitenskapelig artikkel
-
Steen, Kristian Wollen;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Rabe, Renana;
Iveland, Tobias Solli;
Aas, Per Arne.
(2021)
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Maddirevula, Sateesh;
Alameer, Seham;
Ewida, Nour;
Sousa, Mirta;
Bjørås, Magnar;
Vågbø, Cathrine Broberg.
(2021)
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant.
Human Genetics
Vitenskapelig artikkel
2020
-
Boeckemeier, L;
Kraehenbuehl, R;
Keszthelyi, A;
Gasasira, MU;
Vernon, EG;
Beardmore, R.
(2020)
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.
Science Advances
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Slupphaug, Geir.
(2020)
RNA in DNA repair.
DNA Repair
Vitenskapelig artikkel
-
Kong, Xiang Yi;
Vik, Erik Sebastian;
Nawaz, Meh Sameen;
Berges, Natalia;
Dahl, Tuva Børresdatter;
Vågbø, Cathrine.
(2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Schär, Primo;
Schuermann, David;
Schwarz, Simon D.;
Grundbacher, Eliane;
Hrovat, Alexandra M.;
Xu, Jianming.
(2020)
Inducible TDG knockout models to study epigenetic regulation.
F1000
Vitenskapelig artikkel
-
Pandey, Radha Raman;
Delfino, Elena;
Homolka, David;
Roithova, Adriana;
Chen, Kuan-Ming;
Li, Lingyun.
(2020)
The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.
Cell reports
Vitenskapelig artikkel
2019
-
Monies, Dorota;
Vågbø, Cathrine Broberg;
Al-Owain, Mohammad;
Alhomaidi, Suzan;
Alkuraya, Fowzan S..
(2019)
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification.
American Journal of Human Genetics
Vitenskapelig artikkel
-
Pinto, Rita;
Vågbø, Cathrine Broberg;
Jakobsson, Magnus;
Yeji, Kim;
Baltissen, Marijke P;
O'Donohue, Marie-Francoise.
(2019)
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Li, Xiang;
Zhao, Qiongyi;
Wei, Wei;
Lin, Quan;
Magnan, Christophe;
Emami, Michael R.
(2019)
The DNA modification N6-methyl-2 '-eoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.
Nature Neuroscience
Vitenskapelig artikkel
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Vitenskapelig artikkel
2017
-
Brickner, Joshua R;
Soll, Jennifer M;
Lombardi, Patrick M;
Vågbø, Cathrine Broberg;
Mudge, Miranda C;
Oyeniran, Clement.
(2017)
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Nature
Vitenskapelig artikkel
-
Zatula, Alexey;
Dikic, Aida;
Mulder, Teska Celine;
Sharma, Animesh;
Vågbø, Cathrine Broberg;
Sousa, Mirta.
(2017)
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.
OncoTarget
Vitenskapelig artikkel
-
Landfors, Miriam;
Johansen, Jostein;
Aronsen, Jan Magnus;
Vågbø, Cathrine Broberg;
Doré, Louis C.;
He, Chuan.
(2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Cell Discovery
Vitenskapelig artikkel
-
Ke, Shengdong;
Pandya-Jones, Amy;
Saito, Yuhki;
Fak, John J.;
Vågbø, Cathrine Broberg;
Geula, Shay.
(2017)
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.
Genes & Development
Vitenskapelig artikkel
2016
-
Tekpli, Xavier;
Urbanucci, Alfonso;
Hashim, Adnan;
Vågbø, Cathrine Broberg;
Lyle, Robert;
Kringen, Marianne K..
(2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.
Epigenetics & Chromatin
Vitenskapelig artikkel
-
Weber, Alain R.;
Krawczyk, Claudia;
Robertson, Adam Brian;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Schürmann, David.
(2016)
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.
Nature Communications
Vitenskapelig artikkel
-
Rasmussen, Erik;
Vågbø, Cathrine Broberg;
Münch, Daniel;
Krokan, Hans Einar;
Klungland, Arne;
Amdam, Gro Vang.
(2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.
Biochemistry and Biophysics Reports
Vitenskapelig artikkel
2015
-
Ke, Shengdong;
Alemu, Endalkachew Ashenafi;
Mertens, Claudia;
Gantman, Emily Conn;
Fak, John J.;
Mele, Aldo.
(2015)
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes & Development
Vitenskapelig artikkel
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports
Vitenskapelig artikkel
2014
-
Zdzalik, Daria;
Vågbø, Cathrine Broberg;
Kirpekar, F;
Davydova, Erna;
Puścian, Alicja;
Maciejewska, Agnieszka M..
(2014)
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities.
PLOS ONE
Vitenskapelig artikkel
2013
-
Jobert, Laure;
Skjeldam, Hanne Kim;
Dalhus, Bjørn;
Galashevskaya, Anastasia;
Vågbø, Cathrine Broberg;
Bjørås, Magnar.
(2013)
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Molecular Cell
Vitenskapelig artikkel
-
Zheng, Guanqun;
Dahl, John Arne;
Niu, Yamei;
Fedorcsak, Peter;
Huang, Chun-Min;
Li, Charles J..
(2013)
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility.
Molecular Cell
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Vitenskapelig artikkel
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Vitenskapelig artikkel
2012
-
Meza, Trine Johansen;
Moen, Marivi;
Vågbø, Cathrine Broberg;
Krokan, Hans Einar;
Klungland, Arne;
Grini, Paul Eivind.
(2012)
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2011
-
Van den Born, Erwin;
Vågbø, Cathrine Broberg;
Songe-Møller, Lene;
Leihne, VIbeke;
Lien, Guro Flor;
Leszczynska, G.
(2011)
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nature Communications
Vitenskapelig artikkel
-
Robertson, Adam Brian;
Dahl, John Arne;
Vågbø, Cathrine Broberg;
Tripathi, P;
Krokan, Hans Einar;
Klungland, Arne.
(2011)
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Leihne, VIbeke;
Kirpekar, F;
Vågbø, Cathrine Broberg;
Van den Born, Erwin;
Krokan, Hans Einar;
Grini, Paul Eivind.
(2011)
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2010
-
Songe-Møller, Lene;
Van den Born, Erwin;
Leihne, V;
Vågbø, Cathrine Broberg;
Kristoffersen, T;
Krokan, Hans Einar.
(2010)
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding.
Molecular and Cellular Biology
Vitenskapelig artikkel
2009
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
2008
-
Vågbø, Cathrine Broberg.
(2008)
Direct repair of alkylation damage in DNA and RNA by 2-oxoglutarate- and iron-dependent dioxygenases.
NTNU
Doktorgradsavhandling
-
Sundheim, Ottar;
Talstad, Vivi A;
Vågbø, Cathrine Broberg;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
AlkB demethylases flip out in different ways.
DNA Repair
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
2007
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
2006
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Vitenskapelig artikkel
2004
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
2003
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
2001
-
Chatton, Jean-Yves;
Idle, Jefrrey R.;
Vågbø, Cathrine;
Magistretti, Pierre.
(2001)
Insights into the mechanisms of ifosfamide Encephalopathy:Drug Metabolites Have Agonistic Effects on a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid(AMPA) Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons.
Journal of Pharmacology and Experimental Therapeutics
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Schwarz, Simon D.;
Xu, Jianming;
Gunasekera, Kapila;
Schürmann, David;
Vågbø, Cathrine Broberg;
Ferrari, Elena.
(2024)
Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation.
Nature Communications
Vitenskapelig artikkel
-
Dohnalkova, Michaela;
Krasnykov, Kyrylo;
Mendel, Mateusz;
Li, Lingyun;
Panasenko, Olesya;
Fleury-Olela, Fabienne.
(2023)
Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility.
Cell reports
Vitenskapelig artikkel
-
Sherwood, Anna V.;
Rivera-Rangel, Lizandro R.;
Ryberg, Line A.;
Larsen, Helena S.;
Anker, Klara M.;
Costa, Rui.
(2023)
Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide.
Nature
Vitenskapelig artikkel
-
Hayran , Abdul Baset ;
Liabakk, Nina-Beate;
Aas, Per Arne;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Sarno, Antonio.
(2023)
RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Mendel, Mateusz;
Delaney, Kamila;
Pandey, Radha Raman;
Chen, Kuan-Ming;
Wenda, Joanna M.;
Vågbø, Cathrine Broberg.
(2021)
Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Cell
Vitenskapelig artikkel
-
Steen, Kristian Wollen;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Rabe, Renana;
Iveland, Tobias Solli;
Aas, Per Arne.
(2021)
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Maddirevula, Sateesh;
Alameer, Seham;
Ewida, Nour;
Sousa, Mirta;
Bjørås, Magnar;
Vågbø, Cathrine Broberg.
(2021)
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant.
Human Genetics
Vitenskapelig artikkel
-
Boeckemeier, L;
Kraehenbuehl, R;
Keszthelyi, A;
Gasasira, MU;
Vernon, EG;
Beardmore, R.
(2020)
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.
Science Advances
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Slupphaug, Geir.
(2020)
RNA in DNA repair.
DNA Repair
Vitenskapelig artikkel
-
Kong, Xiang Yi;
Vik, Erik Sebastian;
Nawaz, Meh Sameen;
Berges, Natalia;
Dahl, Tuva Børresdatter;
Vågbø, Cathrine.
(2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Schär, Primo;
Schuermann, David;
Schwarz, Simon D.;
Grundbacher, Eliane;
Hrovat, Alexandra M.;
Xu, Jianming.
(2020)
Inducible TDG knockout models to study epigenetic regulation.
F1000
Vitenskapelig artikkel
-
Pandey, Radha Raman;
Delfino, Elena;
Homolka, David;
Roithova, Adriana;
Chen, Kuan-Ming;
Li, Lingyun.
(2020)
The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.
Cell reports
Vitenskapelig artikkel
-
Monies, Dorota;
Vågbø, Cathrine Broberg;
Al-Owain, Mohammad;
Alhomaidi, Suzan;
Alkuraya, Fowzan S..
(2019)
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification.
American Journal of Human Genetics
Vitenskapelig artikkel
-
Pinto, Rita;
Vågbø, Cathrine Broberg;
Jakobsson, Magnus;
Yeji, Kim;
Baltissen, Marijke P;
O'Donohue, Marie-Francoise.
(2019)
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Li, Xiang;
Zhao, Qiongyi;
Wei, Wei;
Lin, Quan;
Magnan, Christophe;
Emami, Michael R.
(2019)
The DNA modification N6-methyl-2 '-eoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.
Nature Neuroscience
Vitenskapelig artikkel
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Vitenskapelig artikkel
-
Brickner, Joshua R;
Soll, Jennifer M;
Lombardi, Patrick M;
Vågbø, Cathrine Broberg;
Mudge, Miranda C;
Oyeniran, Clement.
(2017)
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Nature
Vitenskapelig artikkel
-
Zatula, Alexey;
Dikic, Aida;
Mulder, Teska Celine;
Sharma, Animesh;
Vågbø, Cathrine Broberg;
Sousa, Mirta.
(2017)
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.
OncoTarget
Vitenskapelig artikkel
-
Landfors, Miriam;
Johansen, Jostein;
Aronsen, Jan Magnus;
Vågbø, Cathrine Broberg;
Doré, Louis C.;
He, Chuan.
(2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Cell Discovery
Vitenskapelig artikkel
-
Ke, Shengdong;
Pandya-Jones, Amy;
Saito, Yuhki;
Fak, John J.;
Vågbø, Cathrine Broberg;
Geula, Shay.
(2017)
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.
Genes & Development
Vitenskapelig artikkel
-
Tekpli, Xavier;
Urbanucci, Alfonso;
Hashim, Adnan;
Vågbø, Cathrine Broberg;
Lyle, Robert;
Kringen, Marianne K..
(2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.
Epigenetics & Chromatin
Vitenskapelig artikkel
-
Weber, Alain R.;
Krawczyk, Claudia;
Robertson, Adam Brian;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Schürmann, David.
(2016)
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.
Nature Communications
Vitenskapelig artikkel
-
Rasmussen, Erik;
Vågbø, Cathrine Broberg;
Münch, Daniel;
Krokan, Hans Einar;
Klungland, Arne;
Amdam, Gro Vang.
(2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.
Biochemistry and Biophysics Reports
Vitenskapelig artikkel
-
Ke, Shengdong;
Alemu, Endalkachew Ashenafi;
Mertens, Claudia;
Gantman, Emily Conn;
Fak, John J.;
Mele, Aldo.
(2015)
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes & Development
Vitenskapelig artikkel
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports
Vitenskapelig artikkel
-
Zdzalik, Daria;
Vågbø, Cathrine Broberg;
Kirpekar, F;
Davydova, Erna;
Puścian, Alicja;
Maciejewska, Agnieszka M..
(2014)
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities.
PLOS ONE
Vitenskapelig artikkel
-
Jobert, Laure;
Skjeldam, Hanne Kim;
Dalhus, Bjørn;
Galashevskaya, Anastasia;
Vågbø, Cathrine Broberg;
Bjørås, Magnar.
(2013)
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Molecular Cell
Vitenskapelig artikkel
-
Zheng, Guanqun;
Dahl, John Arne;
Niu, Yamei;
Fedorcsak, Peter;
Huang, Chun-Min;
Li, Charles J..
(2013)
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility.
Molecular Cell
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Vitenskapelig artikkel
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Vitenskapelig artikkel
-
Meza, Trine Johansen;
Moen, Marivi;
Vågbø, Cathrine Broberg;
Krokan, Hans Einar;
Klungland, Arne;
Grini, Paul Eivind.
(2012)
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Van den Born, Erwin;
Vågbø, Cathrine Broberg;
Songe-Møller, Lene;
Leihne, VIbeke;
Lien, Guro Flor;
Leszczynska, G.
(2011)
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nature Communications
Vitenskapelig artikkel
-
Robertson, Adam Brian;
Dahl, John Arne;
Vågbø, Cathrine Broberg;
Tripathi, P;
Krokan, Hans Einar;
Klungland, Arne.
(2011)
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Leihne, VIbeke;
Kirpekar, F;
Vågbø, Cathrine Broberg;
Van den Born, Erwin;
Krokan, Hans Einar;
Grini, Paul Eivind.
(2011)
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Songe-Møller, Lene;
Van den Born, Erwin;
Leihne, V;
Vågbø, Cathrine Broberg;
Kristoffersen, T;
Krokan, Hans Einar.
(2010)
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding.
Molecular and Cellular Biology
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
-
Sundheim, Ottar;
Talstad, Vivi A;
Vågbø, Cathrine Broberg;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
AlkB demethylases flip out in different ways.
DNA Repair
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Vitenskapelig artikkel
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
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Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
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Chatton, Jean-Yves;
Idle, Jefrrey R.;
Vågbø, Cathrine;
Magistretti, Pierre.
(2001)
Insights into the mechanisms of ifosfamide Encephalopathy:Drug Metabolites Have Agonistic Effects on a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid(AMPA) Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons.
Journal of Pharmacology and Experimental Therapeutics
Vitenskapelig artikkel
Rapport
-
Eftedal, Ingrid;
Vågbø, Cathrine Broberg;
Lund, Hedda Juni.
(2022)
Quantification of guanine-derived urinary biomarkers of oxidative stress in saturation divers by LC-MS/MS.
Norges Teknisk Naturvitenskaplige Universitet
Mastergradsoppgave
-
Vågbø, Cathrine Broberg.
(2008)
Direct repair of alkylation damage in DNA and RNA by 2-oxoglutarate- and iron-dependent dioxygenases.
NTNU
Doktorgradsavhandling
UTSTILLING
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Emdal, Elisabeth Fritzke;
Ottestad, Anine Larsen;
Vågbø, Cathrine Broberg;
Skarpeteig, Veronica ;
Rye, Morten Beck.
(2022)
Prøv deg som en DNA-detektiv.
Forskningstorget 2022
Annen presentasjon
Formidling
2024
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PosterLund, Hedda Juni; Wekre, Stian Lande; Eftedal, Ingrid; Vågbø, Cathrine Broberg. (2024) Developing a LC-MS/MS-based method for quantification of guanine-derived urinary biomarkers for oxidative stress in saturation divers . European Underwater and Baromedical Society EUBS Annual Scientific Joint Meeting , Brest 2024-09-16 - 2024-09-20
2022
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Vitenskapelig foredragEldin, Patrick; Vågbø, Cathrine Broberg; Salinas, Sara; Hagiwara, Masatoshi; Slupphaug, Geir; Briant, Laurence. (2022) Le virus Zika reprogramme l'epitranscriptome des ARNt de l'hote pour l'adapter a son biais des codons et faciliter sa traduction. Societe Francaise de Virologie XXIVème Journées Francophones de Virologie , Strasbourg 2022-04-11 - 2022-04-12
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Vitenskapelig foredragSlupphaug, Geir; Dikic, Aida; Berg, Sigrid Karlsen; Sharma, Animesh; Hagen, Lars; Vågbø, Cathrine Broberg. (2022) Enhanced protein translation fidelity – a novel target in multiple myeloma treatment?. Proteomass Scientific Society 8th International Caparica Conference on Analytical Proteomics 2022 , Carparica, Portugal 2022-07-18 - 2022-07-21
2018
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Vitenskapelig foredragVågbø, Cathrine Broberg. (2018) Barneuniversitetet: DNA – livets oppskrift!. Barneuniversitetet/ Kunnskapsbyen Trondheim. Barneuniversitetet: DNA – livets oppskrift! , Melhus Bibliotek 2018-11-03 - 2018-11-03
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PosterVågbø, Cathrine Broberg; Kusnierczyk, Anna; Slupphaug, Geir. (2018) DNA and RNA modification profiling using liquid chromatography – mass spectrometry. EMBO EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice , Capri 2018-10-14 - 2018-10-17
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PosterSlupphaug, Geir; Wollen Steen, Kristian; Rabe, Renana; Hagen, Lars; Aas, Per Arne; Sharma, Animesh. (2018) A role of ASCC3 in the quality control of methylated mRNA. EMBO EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice , Capri 2018-10-14 - 2018-10-17
2017
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Vitenskapelig foredragVågbø, Cathrine Broberg. (2017) Mass spectrometry based analysis of modified DNA and RNA. Matriks Seminar massespektrometri , Oslo 2017-11-02 - 2017-11-02
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Vitenskapelig foredragVågbø, Cathrine Broberg. (2017) Barneuniversitetet: DNA – livets oppskrift!. Barneuniversitetet/ Kunnskapsbyen Trondheim. Barneuniversitetet: DNA – livets oppskrift! , Trondheim Folkebibliotek 2021-04-07 - 2021-04-07
2016
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Vitenskapelig foredragSlupphaug, Geir; Steen, Kristian Wollen; Hagen, Lars; Aas, Per Arne; Sharma, Animesh; Vågbø, Cathrine Broberg. (2016) MMS-induced modifications in mRNA and potential roles of ASCC3/ALKBH3 . The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan , Matsue 2016-11-13 - 2016-11-17
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PosterSharma, Animesh; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Fonseca, Davi de Miranda; Slupphaug, Geir. (2016) PROMEC: Services within Proteomics and DNA/RNA-modomics. NTNU - Faculty of Medicine Seminar for staff at the future Faculty of Medicine and Health Sciences , Scandic Lerkendal Hotel, Trondheim 2016-11-10 - 2016-11-11
2014
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PosterRasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne. (2014) Epigenetically modified cytosines in the honey bee genome. The Ecology of Food Perception Unconventional Model Animals in Food & Health , Oslo 2014-03-20 - 2014-03-21
2013
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PosterRasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne. (2013) Presence of modified cytosines in the honey bee genome. Insect Nutritional Homeostasis , Bonn 2013-05-01 - 2013-05-04
2011
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PosterPettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. UiO 4th EU-USA conference on DNA base damage and repair , Holmenkollen Park Hotell 2011-05-18 - 2011-05-22
2010
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Vitenskapelig foredragMeza, Trine Johansen; Moen, Marivi N.; Vågbø, Cathrine B.; Ulleland, Marius; Krokan, Hans Einar; Arne, Klungland. (2010) The DNA dioxygenase AtALKBH2 protects Arabidopsis thaliana against methylation damage. 9th Norwegian Arabidopsis Meeting , Oslo 2010-11-11 - 2010-11-11
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. NTNU 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
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Vitenskapelig foredragVågbø, Cathrine Broberg. (2010) Biological applications of mass spectrometry in the analysis of DNA and RNA modifications. The 6th Norwegian Proteomics Conference 2010-12-09 - 2010-12-10
2009
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair 2009-06-20 - 2009-06-25
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PosterHenrik Sahlin, Pettersen; Visnes, Torkild; Vågbø, Cathrine Broberg; Kavli, Bodil Merete; Krokan, Hans Einar. (2009) Cytotoxicity of 5-fluorouracil is mainly due to RNA effects and thymidylate synthase inhibition, not excessive DNA repair. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair , Ålesund og Geiranger 2009-06-20 - 2009-06-25
2008
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Vitenskapelig foredragVågbø, Cathrine Broberg. (2008) RNA repair by AlkB proteins - fact or fiction?. Inst. for Kreftforskning og Molekylær Medisin Faglig seminar Inst. for Kreftforskning og Molekylær Medisin 2008-11-11 - 2008-11-11
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Vitenskapelig foredragSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance , St. Petersburg 2008-06-24 - 2008-06-26
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Vitenskapelig foredragVågbø, Cathrine Broberg. (2008) ALKB mediert RNA reparasjon. IKM Tirsdagsmøter ved Institutt for kreftforskning og molekylær medisin , Trondheim 2008-11-11 -
2007
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Vitenskapelig foredragVågbø, Cathrine Broberg. (2007) Repair of RNA alkylation damage - in vivo?. Avd. for Kreftforskning og Molekylær Medisin, NTNU Fagmøte på Avd. for Kreftforskning og Molekylær Medisin , Laboratoriesenteret, NTNU 2007-09-10 - 2007-09-10
2006
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Vitenskapelig foredragVågbø, Cathrine Broberg. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA (oral presentation). EU Integrated Project “DNA Damage Response and Rep. Mech." DNA Repair: from Molecular Mechanism to Human Disease , Noordwijkerhout 2006-04-02 - 2006-04-07
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Vitenskapelig foredragVågbø, Cathrine Broberg. (2006) The in vivo role of mouse AlkB homologue 2 and 3 assessed through LC/MS/MS. Institutt for Kreftforskning og Molekylær Medisin, NTNU Tirsdagsseminar Institutt for Kreftforskning og Molekylær Medisin , Trondheim 2006-10-24 - 2006-10-24
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PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Talstad, Vivi; Aas, Per Arne. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Erling Seeberg Symposium on DNA Repair 2006-05-28 - 2006-06-02
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PosterSousa, Mirta; Sundheim, Ottar; Vågbø, Cathrine Broberg; Talstad, Vivi; Aslaksen, Petter Broby; Slupphaug, Geir. (2006) Post-translational self-hydroxilation of an active site leucine in human ABH3 may protect against generation of damaging oxygen radicals. Erling Seeberg Symposium on DNA Repair , Bodø og Hennigsvær 2006-05-28 - 2006-06-02
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PosterVågbø, Cathrine Broberg; Talstad, Vivi; Aas, Per Arne; Krokan, Hans Einar. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA. EU Integrated Project “DNA Damage Response and Rep. Mech." DNA Repair: from Molecular Mechanism to Human Disease , Noordwijkerhout 2006-04-02 - 2006-04-07
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PosterVågbø, Cathrine Broberg; Talstad, Vivi; Aas, Per Arne; Krokan, Hans Einar. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA. Universitet i Oslo Erling Seeberg Symposium on DNA repair , Henningsvær, Lofoten 2006-05-28 - 2006-06-02
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PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2006) Crystal structure of hABH3 DNA/RNA demethylase reveals a novel active-site leucine oxidation. Norwegian Biochemical Society (NBS) The Norwegian Biochemical Society 42. Contact Meeting , Storefjell, Storefjell Hotell 2006-01-19 - 2006-01-22
2005
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PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2005) Structure of the hABH3 DNA demethylase implicates an oxidized leucine residue in catalysis. 2nd ESF Functional Genomics and disease 2005-09-06 -
2004
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Vitenskapelig foredragHagen, Lars; Vågbø, Cathrine Broberg. (2004) Mass spectrometry applications at Institute of Cancer Research and Molecular Medicine, NTNU, Trondheim. Norsk selskap for massespektrometri Møte i Norsk selskap for massespektrometri , Bergen 2004-05-10 -
2002
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PosterVisnes, Torkild; Vågbø, Cathrine; Akbari, Mansour; Krokan, Hans Einar. (2002) To BER or not to BER - is that the question?. Norsk Biokjemisk Selskaps Vintermøte , Røros, Norge 2002-01-20 -
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PosterVisnes, Torkild; Vågbø, Cathrine; Akbari, Mansour; Krokan, Hans Einar. (2002) The signifisance of variation of uracil DNA.glycosylase activity on uracil initiated base exicion repair. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life , Quality Hotel Røros 2002-01-20 -
1999
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Populærvitenskapelig foredragVågbø, Cathrine Broberg; Brunsvik, Anders; Zahlsen, Kolbjørn; Hadidi, Hakam; Idle, Jeffrey R.. (1999) Phenotypic and excessive 3-hydroxylation of coumarin, a ubiquitous environmental contaminant. 35. Biokjemiske kontaktmøte NBS , Tromsø, 21 - 24. januar 1999
1998
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PosterVågbø, Cathrine B.; Haidid, Hakam; Idle, Jeffrey. (1998) Thiodiglycolic acid a novel endogenous urinary metabolite in humans. Biokjemisk kontaktmøte , Lillehammer