Borgny Ytterhus
73598434
Laboratoriesenteret, 231.04.034, Øya, Erling Skjalgsonsgt 1
Om
Senioringeniør
Fast ansatt i IKOM, tilknyttet AICAN og Breast Cancer Subtypes (BCS)
Arbeidssted: Laboratoriesenteret, 4.etg øst, Histologilaboratoriet
Kompetanse på histologiske metoder og anvendelse av tilhørende automatiske roboter eller utstyr/ instrumenter, mikroskoper og scannere
- Immunhistokjemi / Immunfluorescence for å påvise spesifikke proteiner uttrykt i celler og vev
- In Situ Hybridisering med DNA- prober for molekylærpatologi. Visualiserer spesifikke kromosomer og gener i cellekjernen.
-TMA(Tissue Micro Array): Et større antall vevsbiter samles i en enkeltmatrise for å rasjonalisere og standardisere ulike analyser . v hj a MiniCore TMA instrument og Alphelys SoftWare
-Digitalisering av fargete vevssnitt med Olympus scanner
-Fiksering, dehydrering og parafininnstøpning av vev.
-Fremstilling av snitt fra parafininnstøpt og frosset vev
-Farging av vevssnitt. Sakura/ TissueTek farge- og oppleggsmaskin
Publikasjoner
2025
-
Høibø, Maren;
Spiske, Ute;
Pedersen, Andre;
Ytterhus, Borgny;
Akslen, Lars Andreas;
Wik, Elisabeth.
(2025)
Predicting estrogen receptor status from HE-stained breast cancer slides using artificial intelligence.
Frontiers in Medicine
Vitenskapelig artikkel
-
Meta, Rahmina;
Pettersen, Henrik Sahlin;
Tollefsen, Sofie Eline;
Ytterhus, Borgny;
Salvesen, Øyvind Olav;
Sjursen, Wenche.
(2025)
Tumour-associated macrophages in human meningiomas.
PLOS ONE
Vitenskapelig artikkel
2024
-
Meta, Rahmina;
Pettersen, Henrik Sahlin;
Tollefsen, Sofie Eline;
Ytterhus, Borgny;
Salvesen, Øyvind;
Sjursen, Wenche.
(2024)
Clinicopathological aspects of tumour-associated macrophages in human meningiomas.
Neuropathology and Applied Neurobiology
Sammendrag/Abstract
2023
-
Børkja, Mathieu;
Giambelluca, Miriam Soledad;
Ytterhus, Borgny;
Prestvik, Wenche Slettahjell;
Bjørkøy, Geir;
Bofin, Anna M..
(2023)
S100A8 gene copy number and protein expression in breast cancer: associations with proliferation, histopathological grade and molecular subtypes.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
-
Skjervold, Anette Hansen;
Valla, Marit;
Ytterhus, Borgny;
Bofin, Anna M..
(2023)
PAK1 copy number in breast cancer—Associations with proliferation and molecular subtypes.
PLOS ONE
Vitenskapelig artikkel
-
Saastad, Sigurd August;
Skjervold, Anette Hansen;
Ytterhus, Borgny;
Engstrøm, Monica Jernberg;
Bofin, Anna M..
(2023)
PD-L1 protein expression in breast cancer.
Journal of Clinical Pathology
Vitenskapelig artikkel
2022
-
Valla, Marit;
Klæstad, Elise;
Ytterhus, Borgny;
Bofin, Anna M..
(2022)
CCND1 amplification in breast cancer -associations with proliferation, histopathological grade, molecular subtype and prognosis.
Journal of mammary gland biology and neoplasia
Vitenskapelig artikkel
2021
-
Bofin, Anna M.;
Ytterhus, Borgny;
Klæstad, Elise;
Valla, Marit.
(2021)
FGFR1 copy number in breast cancer: associations with proliferation, histopathological grade and molecular subtypes.
Journal of Clinical Pathology
Vitenskapelig artikkel
-
Klæstad, Elise;
Sawicka, Joanna Ewa;
Engstrøm, Monica J;
Ytterhus, Borgny;
Valla, Marit;
Bofin, Anna M..
(2021)
ZNF703 gene copy number and protein expression in breast cancer; associations with proliferation, prognosis and luminal subtypes.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
-
Tollefsen, Sofie Eline;
Jarmund, Anders Hagen;
Ytterhus, Borgny;
Salvesen, Øyvind;
Mjønes, Patricia;
Torp, Sverre Helge.
(2021)
Somatostatin receptors in human meningiomas—clinicopathological aspects.
Cancers
Vitenskapelig artikkel
-
Valla, Marit;
Opdahl, Signe;
Ytterhus, Borgny;
Bofin, Anna M..
(2021)
DTX3 copy number increase in breast cancer: a study of associations to molecular subtype, proliferation and prognosis.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
2020
-
Klæstad, Elise;
Opdahl, Signe;
Engstrøm, Monica J;
Ytterhus, Borgny;
Wik, Elisabeth;
Bofin, Anna Mary.
(2020)
MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
2018
-
Valla, Marit;
Mjønes, Patricia;
Engstrøm, Monica J;
Ytterhus, Borgny;
Bordin, Diana Lilian;
Loon, Barbara van.
(2018)
Characterization of FGD5 expression in primary breast cancers and lymph node metastases.
Journal of Histochemistry and Cytochemistry
Vitenskapelig artikkel
2017
-
Arnli, Magnus Bossum;
Backer-Grøndahl, Thomas;
Ytterhus, Borgny;
Granli, Unn Sophie;
Lydersen, Stian;
Gulati, Sasha.
(2017)
Expression and clinical value of EGFR in human meningiomas.
PeerJ
Vitenskapelig artikkel
-
Valla, Marit;
Engstrøm, Monica J;
Ytterhus, Borgny;
Hansen, Åse Kristin Skain;
Akslen, Lars A.;
Vatten, Lars Johan.
(2017)
FGD5 amplification in breast cancer patients is associated with tumor proliferation and a poorer prognosis.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
2016
-
Valla, Marit;
Vatten, Lars Johan;
Engstrøm, Monica J;
Haugen, Olav Anton;
Akslen, Lars A.;
Bjørngaard, Johan Håkon.
(2016)
Molecular subtypes of breast cancer: Long-term incidence trends and prognostic differences.
Cancer Epidemiology, Biomarkers and Prevention
Vitenskapelig artikkel
2014
-
Engstrøm, Monica J;
Ytterhus, Borgny;
Vatten, Lars Johan;
Opdahl, Signe;
Bofin, Anna M..
(2014)
TOP2A gene copy number change in breast cancer.
Journal of Clinical Pathology
Vitenskapelig artikkel
2010
-
Berggren, Elena M.Trounina;
Almas, T;
Ytterhus, Borgny;
Angelsen, Anders;
Bofin, Anna M..
(2010)
CYTOLOGIC EXAMINATION AND FISH IN THE DETECTION OF ATYPICAL UROTHELIAL CELLS IN SPONTANEOUS URINE SPECIMENS AND BLADDER WASHINGS IN PATIENTS WITH A HISTORY OF CARCINOMA OF THE URINARY BLADDER.
Acta Cytologica
Sammendrag/Abstract
-
Gulati, Sasha;
Ytterhus, Borgny;
Granli, Unn Sophie;
Gulati, Michel;
Lydersen, Stian;
Torp, Sverre Helge.
(2010)
Overexpression of c-erbB2 is a negative prognostic factor in anaplastic astrocytomas.
Diagnostic Pathology
Vitenskapelig artikkel
2009
-
Ytterhus, Borgny;
Engesvold, Ingeborg;
Vogt, Christina.
(2009)
Deteksjon av kromosomavvik i formalinfiksert og parafininnstøpt autopsimateriale fra fostre ved hjelp av FISH.
Bioingeniøren
Vitenskapelig artikkel
2007
-
Hagen, Anne Irene;
Bofin, Anna M.;
Ytterhus, Borgny;
Mæhle, Lovise;
Kjellevold, Kjell Henning;
Møller, Pål.
(2007)
Amplification of TOP2A and HER-2 genes in breast cancers occurring in patients harbouring BRCA1 germline mutations.
Acta Oncologica
Vitenskapelig artikkel
2004
-
Bofin, Anna M.;
Ytterhus, Borgny;
Martin, Cara;
O'Leary, John J.;
Hagmar, Bjørn M.
(2004)
Detection and quantitation of HER-2 gene amplification and protein expression in breast carcinoma.
American Journal of Clinical Pathology
Vitenskapelig artikkel
2003
-
Bofin, Anna M.;
Fjøsne, Hans E.;
Hagmar, Bjørn M.;
Ytterhus, Borgny.
(2003)
Abnormal chromosome 8 copy number in cytological smears from breast carcinoma detected by means of fluorescence in situ hybridization (FISH).
Cytopathology
Vitenskapelig artikkel
-
Bofin, Anna M.;
Hagmar, Bjørn M.;
Ytterhus, Borgny.
(2003)
TOP2A and HER2 gene amplification in fine needle aspirates from breast carcinoma.
Cytopathology
Vitenskapelig artikkel
2000
-
Isaksen, Christina Vogt;
Ytterhus, Borgny;
Skarsvåg, Sølvi.
(2000)
Detection of Trisomy 18 on Formalin-fixed and Paraffin-embedded Material by Fluorescence In Situ Hybridization.
Pediatric and Developmental Pathology
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Høibø, Maren;
Spiske, Ute;
Pedersen, Andre;
Ytterhus, Borgny;
Akslen, Lars Andreas;
Wik, Elisabeth.
(2025)
Predicting estrogen receptor status from HE-stained breast cancer slides using artificial intelligence.
Frontiers in Medicine
Vitenskapelig artikkel
-
Meta, Rahmina;
Pettersen, Henrik Sahlin;
Tollefsen, Sofie Eline;
Ytterhus, Borgny;
Salvesen, Øyvind Olav;
Sjursen, Wenche.
(2025)
Tumour-associated macrophages in human meningiomas.
PLOS ONE
Vitenskapelig artikkel
-
Meta, Rahmina;
Pettersen, Henrik Sahlin;
Tollefsen, Sofie Eline;
Ytterhus, Borgny;
Salvesen, Øyvind;
Sjursen, Wenche.
(2024)
Clinicopathological aspects of tumour-associated macrophages in human meningiomas.
Neuropathology and Applied Neurobiology
Sammendrag/Abstract
-
Børkja, Mathieu;
Giambelluca, Miriam Soledad;
Ytterhus, Borgny;
Prestvik, Wenche Slettahjell;
Bjørkøy, Geir;
Bofin, Anna M..
(2023)
S100A8 gene copy number and protein expression in breast cancer: associations with proliferation, histopathological grade and molecular subtypes.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
-
Skjervold, Anette Hansen;
Valla, Marit;
Ytterhus, Borgny;
Bofin, Anna M..
(2023)
PAK1 copy number in breast cancer—Associations with proliferation and molecular subtypes.
PLOS ONE
Vitenskapelig artikkel
-
Saastad, Sigurd August;
Skjervold, Anette Hansen;
Ytterhus, Borgny;
Engstrøm, Monica Jernberg;
Bofin, Anna M..
(2023)
PD-L1 protein expression in breast cancer.
Journal of Clinical Pathology
Vitenskapelig artikkel
-
Valla, Marit;
Klæstad, Elise;
Ytterhus, Borgny;
Bofin, Anna M..
(2022)
CCND1 amplification in breast cancer -associations with proliferation, histopathological grade, molecular subtype and prognosis.
Journal of mammary gland biology and neoplasia
Vitenskapelig artikkel
-
Bofin, Anna M.;
Ytterhus, Borgny;
Klæstad, Elise;
Valla, Marit.
(2021)
FGFR1 copy number in breast cancer: associations with proliferation, histopathological grade and molecular subtypes.
Journal of Clinical Pathology
Vitenskapelig artikkel
-
Klæstad, Elise;
Sawicka, Joanna Ewa;
Engstrøm, Monica J;
Ytterhus, Borgny;
Valla, Marit;
Bofin, Anna M..
(2021)
ZNF703 gene copy number and protein expression in breast cancer; associations with proliferation, prognosis and luminal subtypes.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
-
Tollefsen, Sofie Eline;
Jarmund, Anders Hagen;
Ytterhus, Borgny;
Salvesen, Øyvind;
Mjønes, Patricia;
Torp, Sverre Helge.
(2021)
Somatostatin receptors in human meningiomas—clinicopathological aspects.
Cancers
Vitenskapelig artikkel
-
Valla, Marit;
Opdahl, Signe;
Ytterhus, Borgny;
Bofin, Anna M..
(2021)
DTX3 copy number increase in breast cancer: a study of associations to molecular subtype, proliferation and prognosis.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
-
Klæstad, Elise;
Opdahl, Signe;
Engstrøm, Monica J;
Ytterhus, Borgny;
Wik, Elisabeth;
Bofin, Anna Mary.
(2020)
MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
-
Valla, Marit;
Mjønes, Patricia;
Engstrøm, Monica J;
Ytterhus, Borgny;
Bordin, Diana Lilian;
Loon, Barbara van.
(2018)
Characterization of FGD5 expression in primary breast cancers and lymph node metastases.
Journal of Histochemistry and Cytochemistry
Vitenskapelig artikkel
-
Arnli, Magnus Bossum;
Backer-Grøndahl, Thomas;
Ytterhus, Borgny;
Granli, Unn Sophie;
Lydersen, Stian;
Gulati, Sasha.
(2017)
Expression and clinical value of EGFR in human meningiomas.
PeerJ
Vitenskapelig artikkel
-
Valla, Marit;
Engstrøm, Monica J;
Ytterhus, Borgny;
Hansen, Åse Kristin Skain;
Akslen, Lars A.;
Vatten, Lars Johan.
(2017)
FGD5 amplification in breast cancer patients is associated with tumor proliferation and a poorer prognosis.
Breast Cancer Research and Treatment
Vitenskapelig artikkel
-
Valla, Marit;
Vatten, Lars Johan;
Engstrøm, Monica J;
Haugen, Olav Anton;
Akslen, Lars A.;
Bjørngaard, Johan Håkon.
(2016)
Molecular subtypes of breast cancer: Long-term incidence trends and prognostic differences.
Cancer Epidemiology, Biomarkers and Prevention
Vitenskapelig artikkel
-
Engstrøm, Monica J;
Ytterhus, Borgny;
Vatten, Lars Johan;
Opdahl, Signe;
Bofin, Anna M..
(2014)
TOP2A gene copy number change in breast cancer.
Journal of Clinical Pathology
Vitenskapelig artikkel
-
Berggren, Elena M.Trounina;
Almas, T;
Ytterhus, Borgny;
Angelsen, Anders;
Bofin, Anna M..
(2010)
CYTOLOGIC EXAMINATION AND FISH IN THE DETECTION OF ATYPICAL UROTHELIAL CELLS IN SPONTANEOUS URINE SPECIMENS AND BLADDER WASHINGS IN PATIENTS WITH A HISTORY OF CARCINOMA OF THE URINARY BLADDER.
Acta Cytologica
Sammendrag/Abstract
-
Gulati, Sasha;
Ytterhus, Borgny;
Granli, Unn Sophie;
Gulati, Michel;
Lydersen, Stian;
Torp, Sverre Helge.
(2010)
Overexpression of c-erbB2 is a negative prognostic factor in anaplastic astrocytomas.
Diagnostic Pathology
Vitenskapelig artikkel
-
Ytterhus, Borgny;
Engesvold, Ingeborg;
Vogt, Christina.
(2009)
Deteksjon av kromosomavvik i formalinfiksert og parafininnstøpt autopsimateriale fra fostre ved hjelp av FISH.
Bioingeniøren
Vitenskapelig artikkel
-
Hagen, Anne Irene;
Bofin, Anna M.;
Ytterhus, Borgny;
Mæhle, Lovise;
Kjellevold, Kjell Henning;
Møller, Pål.
(2007)
Amplification of TOP2A and HER-2 genes in breast cancers occurring in patients harbouring BRCA1 germline mutations.
Acta Oncologica
Vitenskapelig artikkel
-
Bofin, Anna M.;
Ytterhus, Borgny;
Martin, Cara;
O'Leary, John J.;
Hagmar, Bjørn M.
(2004)
Detection and quantitation of HER-2 gene amplification and protein expression in breast carcinoma.
American Journal of Clinical Pathology
Vitenskapelig artikkel
-
Bofin, Anna M.;
Fjøsne, Hans E.;
Hagmar, Bjørn M.;
Ytterhus, Borgny.
(2003)
Abnormal chromosome 8 copy number in cytological smears from breast carcinoma detected by means of fluorescence in situ hybridization (FISH).
Cytopathology
Vitenskapelig artikkel
-
Bofin, Anna M.;
Hagmar, Bjørn M.;
Ytterhus, Borgny.
(2003)
TOP2A and HER2 gene amplification in fine needle aspirates from breast carcinoma.
Cytopathology
Vitenskapelig artikkel
-
Isaksen, Christina Vogt;
Ytterhus, Borgny;
Skarsvåg, Sølvi.
(2000)
Detection of Trisomy 18 on Formalin-fixed and Paraffin-embedded Material by Fluorescence In Situ Hybridization.
Pediatric and Developmental Pathology
Vitenskapelig artikkel
Formidling
2024
-
PosterMeta, Rahmina; Pettersen, Henrik Sahlin; Tollefsen, Sofie Eline; Ytterhus, Borgny; Salvesen, Øyvind Olav; Sjursen, Wenche. (2024) The clinicopathological role of tumour-associated macrophages in human meningiomas. SNOG SYMPOSIUM 2024 – Multidisciplinary Neuro-Oncology Meeting , Gøteborg 2024-04-25 - 2024-04-27
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Faglig foredragMeta, Rahmina; Pettersen, Henrik Sahlin; Tollefsen, Sofie Eline; Ytterhus, Borgny; Salvesen, Øyvind Olav; Sjursen, Wenche. (2024) Tumorassosierte makrofager i meningeomer. Årsmøte i Den norske patologforening , Britannia Hotell, Trondheim, Norge 2024-04-11 -
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PosterMeta, Rahmina; Pettersen, Henrik Sahlin; Tollefsen, Sofie Eline; Ytterhus, Borgny; Salvesen, Øyvind; Sjursen, Wenche. (2024) Clinicopathological aspects of tumour-associated macrophages in human meningiomas. 125TH Meeting of the British Neuropathological Society , London 2024-01-31 - 2024-02-02
2023
-
PosterAraste, Hannie; Kvisten, Magnus; Ytterhus, Borgny; Salvesen, Øyvind Olav; Skjulsvik, Anne Jarstein; Pettersen, Henrik Sahlin. (2023) Microglia and macrophages in human glioblastomas: Distribution and relations to tumour growth. 20th Internation Congress of Neuropathology , Berlin 2023-09-13 - 2023-09-16
2020
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PosterSkjervold, Anette Hansen; Pettersen, Henrik Sahlin; Ytterhus, Borgny; Valla, Marit; Bofin, Anna M.. (2020) Cell counts in visual and digital assessment of Ki-67 in breast cancer. 32nd congress of the ESP and XXXIII International Congress of the IAP 2020 , Glasgow - virtual congress 2020-12-06 - 2020-12-08
2016
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Vitenskapelig foredragValla, Marit; Engstrøm, Monica J; Ytterhus, Borgny; Hansen, Åse Kristin Skain; Akslen, Lars A.; Vatten, Lars Johan. (2016) FGD5 amplification in breast cancer patients is associated with tumour proliferation and a poorer prognosis. Annual Workshop on Breast Cancer , Kongsvold 2016-09-13 - 2016-09-14
-
PosterValla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon. (2016) Molecular subtypes of breast cancer: Long term incidence trends and prognostic differences. The third international molecular pathological epidemiology (MPE) meeting , Dana-Farber Cancer Institute, Boston 2016-05-12 - 2016-05-13
-
Vitenskapelig foredragValla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon. (2016) Molecular subtypes of breast cancer: long-term incidence trends and prognostic differences. Scandinavian Pathology Seminar, Sotra , Sotra 2016-08-30 - 2016-08-31
2014
-
PosterEngstrøm, Monica J; Ytterhus, Borgny; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M.. (2014) TOP2A gene copy number change in breast cancer. 26th European Congress of Pathology , London 2014-08-30 - 2014-09-03
-
PosterKraby, Maria Ryssdal; Opdahl, Signe; Krüger, Kristi; Ytterhus, Borgny; Akslen, Lars A.; Bofin, Anna M.. (2014) Microvascular proliferation in breast cancer. 26th European Congress of Pathology , London 2014-08-30 - 2014-09-03
2013
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Vitenskapelig foredragEngstrøm, Monica J; Ytterhus, Borgny; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M.. (2013) Endringer i TOP2A-genet ved brystkreft. Kirurgisk høstmøte 2013 , Oslo 2013-10-23 - 2013-10-25
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Vitenskapelig foredragEngstrøm, Monica J; Ytterhus, Borgny; Dyrnes, Linda Anita; Vatten, Lars Johan; Bofin, Anna M.. (2013) TOP2A genamplifikasjon ved brystkreft. Årsmøte i Norsk forening for Patologi , Trondheim 2013-03-15 - 2013-03-16
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PosterDyrnes, Linda Anita; Ytterhus, Borgny; Sandberg, Nina; Engstrøm, Monica J; Bofin, Anna M.. (2013) Tissue Microarray in a Large, Historic Breast Cancer Cohort Study. Nordic Medical Laboratory group (NML) Conference 2013 , Trondheim 2013-06-13 - 2013-06-15
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Vitenskapelig foredragYtterhus, Borgny; Dyrnes, Linda Anita; Sandberg, Nina; Engstrøm, Monica J; Bofin, Anna M.. (2013) Visualizing Genes and Chromosomes in Archival Tissue Biopsies. Nordic Medical Laboratory group (NML) 2013 , Trondheim 2013-06-13 - 2013-06-15
2012
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PosterEngstrøm, Monica J; Opdahl, Signe; Sandberg, Nina; Ytterhus, Borgny; Dyrnes, Linda Anita; Vatten, Lars Johan. (2012) Molecular subtypes and survival. Cohort 1 in Breast Cancer Subtypes Project A unique material with a long follow-up. Preliminary results. OSBREAC (Oslo breast cancer consortium) Workshop , Kongsvold Fjeldstue 2012-08-29 - 2012-08-31
2010
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PosterBerggren, Elena; Almås, Tora; Ytterhus, Borgny; Angelsen, Anders; Bofin, Anna M.. (2010) Cytological examination and FISH in the detection of atypical urothelial cells in spontaneous urine specimens and bladder washings. 17th International Congress of Cytology , Edinburgh 2010-05-16 - 2010-05-20
2007
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PosterYtterhus, Borgny; Sandberg, Nina; Bofin, Anna M.. (2007) FISHing for Genes and Chromosomes in FNA Smears. XXXIII European Congress of Cytology , Madrid 2007-10-14 - 2007-10-17
2004
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Vitenskapelig foredragBofin, Anna M.; Ytterhus, Borgny; Hagmar, Bjørn M. (2004) TOP2A og HER2 genamplifikasjon i mammakarsinom. Foredrag , Oslo 2004-01-30 - 2004-01-31
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Vitenskapelig foredragBofin, Anna M.; Ytterhus, Borgny; Hagmar, Bjørn M. (2004) TOP2A og HER2 genamplifikasjon i mammakarsinom. Regionalmøte - NBCG , Trondheim 2004-01-19 - 2004-01-19
2003
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Vitenskapelig foredragBofin, Anna M.; Hagmar, Bjørn M.; Ytterhus, Borgny. (2003) Topoisomerase IIalpha and Her2 gene amplification in fine needle aspirates from breast carcinomas. 29th European Congress of Cytology , Prague 2003-10-08 -