Bakgrunn og aktiviteter
Jeg er utdannet sivilingeniør i bioteknologi og jeg har en doktorgrad i farmakologi. Tidligere har jeg jobbet i flere laboratorier både nasjonalt og internasjonalt innenfor ulike disipliner. Gjennom min doktorgrad ble jeg en spesialist på forskning innen lipidmetabolisme i forbindelse med type 2 diabetes og fedme i muskelceller. Jeg har også erfaring med ulike levende celle imaging teknikker og undervisning, samt analyser av store gen data sett.
Jeg jobber som post doc ved CEMIR, IKM, NTNU. Her jobber jeg med å avsløre mekanismene bak inflammasjon og komplement aktivering i forhold til kolesterol krystall opphopning i aterosklerotiske plakk og med å finne nye behandlinger mot aterosklerose. 15 september 2014 - 1 juni 2015 hadde jeg et utlandsopphold hos Prof Eicke Latz ved Universitetet i Bonn i Tyskland.
Vitenskapelig, faglig og kunstnerisk arbeid
Et utvalg av nyere tidsskriftspublikasjoner, kunstneriske produksjoner, bok, inklusiv bokdeler og rapport-del. Se alle publikasjoner i databasen
Tidsskriftspublikasjoner
- (2017) Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation. Journal of Immunology. vol. 199 (8).
- (2017) Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. Journal of Lipid Research. vol. 58 (11).
- (2016) Cholesterol crystals activate the lectin complement pathway via ficolin-2 and mannose-binding lectin: Implications for the progression of atherosclerosis. Journal of Immunology. vol. 196 (12).
- (2016) Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine. vol. 8 (333).
- (2015) Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects. PLoS ONE. vol. 10 (3).
- (2015) Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise. American Journal of Physiology - Cell Physiology. vol. 308 (7).
- (2015) Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. vol. 1851 (9).
- (2015) Reconstituted high-density lipoprotein attenuates cholesterol crystal-induced inflammatory responses by reducing complement activation. Journal of Immunology. vol. 195 (1).
- (2014) PPARδ activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference. Archives of Physiology and Biochemistry. vol. 120 (1).
- (2014) Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release. Journal of Immunology. vol. 192 (6).
- (2013) Are cultured human myotubes far from home?. Cell and Tissue Research. vol. 354 (3).
- (2013) Remodelling of oxidative energy metabolism by galactose improves glucose handling and metabolic switching in human skeletal muscle cells. PLoS ONE. vol. 8 (4).
- (2012) Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. vol. 1821 (10).
- (2012) Expression of perilipins in human skeletal muscle in vitro and in vivo in relation to diet, exercise and energy balance. Archives of Physiology and Biochemistry. vol. 118 (1).
- (2012) The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. Journal of Steroid Biochemistry and Molecular Biology. vol. 128.
- (2012) Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise. PLoS ONE. vol. 7 (3).
- (2011) Metabolic switching of human skeletal muscle cells in vitro. Prostaglandins, Leukotrienes and Essential Fatty Acids. vol. 85 (5).
- (2010) Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids. American Journal of Physiology. Endocrinology and Metabolism. vol. 299 (1).
- (2010) Metabolic switching of human myotubes is improved by n-3 fatty acids. Journal of Lipid Research. vol. 51 (8).
Rapport/avhandling
- (2013) Regulation of energy metabolism in human skeletal muscle cells. Effects of fatty acids, in vitro exercise and extreme obesity with and without type 2 diabetes. Akademika forlag. 2013. Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo. (1319).