Marianne Sandvold Beckwith
Om
Jeg er utdannet sivilingeniør fra NTNU, og har interessert meg spesielt for mikroskopi og karakteriseringsmetoder for biologiske applikasjoner helt siden studietiden. Biologien er fantastisk, og med en god forståelse av fysikken bak observasjonsmetodene er det uendelig mye nytt å lære.
Jeg tok doktorgrad på tuberkuloseinfeksjon ved senter for molekylær inflammasjonsforskning, der vi ved hjelp av avanserte mikroskopimetoder oppdaget hvordan tuberkulosebakterier kan drepe sine vertsceller ved å lage hull i plasmamembranen, som også gir en inflammatorisk respons. Mikroskopimetodene vi utviklet ble nyttige i mitt videre arbeid som posdoc ved European Molecular Biology Laboratory (EMBL) i Heidelberg, der jeg jobbet med å forstå hvordan immunceller migrerer så raskt rundt i kroppen. Vi fant ut at kurvatursensitive proteiner i cellene hjelper dem med å navigere rundt hindringer.
Gjennom mitt arbeid som PhD og postdoktor har jeg fått innblikk i en rekke prosjekter innen forskjellige fagfelt, fra molekylærbiologi og biofysikk til mikroskopi og metodeutvikling. Jeg har sett hvor muliggjørende mikroskopimetoder kan være, og brenner for å videreformidle kunnskapen til det beste for våre forskningsmiljø på NTNU.
Kompetanseord
Forskning
Link til ORCID: Marianne Sandvold Beckwith (0000-0001-8235-3755) - ORCID
Publikasjoner
Link til ORCID: Marianne Sandvold Beckwith (0000-0001-8235-3755) - ORCID
2020
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Beckwith, Kai Sandvold;
Beckwith, Marianne Sandvold;
Ullmann, Sindre;
Sætra, Ragnhild Sofie Ragnhildstveit;
Kim, Hae Lin;
Marstad, Anne;
Åsberg, Signe Elisabeth;
Strand, Trine Aakvik;
Haug, Markus;
Niederweis, Michael.
(2020)
Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection.
Nature Communications
Vitenskapelig artikkel
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Meås, Hany Zakaria;
Haug, Markus;
Beckwith, Marianne Sandvold;
Louet, Claire;
Ryan, Liv;
Hu, Zhenyi;
Landskron, Johannes;
Nordbø, Svein Arne;
Tasken, Kjetil;
Yin, Hang.
(2020)
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency.
Nature Communications
Vitenskapelig artikkel
2019
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Haug, Markus;
Meås, Hany Zakaria;
Beckwith, Marianne Sandvold;
Louet, Claire;
Ryan, Liv;
Hu, Z.;
Landskron, Johannes;
Nordbø, Svein Arne;
Tasken, Kjetil;
Yin, H. H..
(2019)
P1511 - Sensing of HIV-1 nucleic acids by TLR8 in human CD4+ T cells.
European Journal of Immunology
Konferanseabstract
2018
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Beckwith, Marianne;
Flo, Trude Helen;
Halaas, Øyvind.
(2018)
Targeted correlative light and electron microscopy in the study of host-pathogen interactions.
Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
2015
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Beckwith, Marianne;
Beckwith, Kai Sandvold;
Sikorski, Pawel;
Skogaker, Nan Elisabeth Tostrup;
Flo, Trude Helen;
Halaas, Øyvind.
(2015)
Seeing a mycobacterium-infected cell in nanoscale 3D: Correlative imaging by light microscopy and FIB/SEM tomography.
PLOS ONE
Vitenskapelig artikkel
2014
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Magnus Østgård, Olderøy;
Lilledahl, Magnus Borstad;
Beckwith, Marianne;
Melvik, Jan Egil;
Reinholt, Finn P.;
Sikorski, Pawel;
Brinchmann, Jan E..
(2014)
Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels.
PLOS ONE
Vitenskapelig artikkel
2013
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Beckwith, Marianne;
Sikorski, Pawel.
(2013)
Technical Aspects of Ion Milling and Electron Imaging of Epoxy Embedded Samples for FIB/SEM Tomography.
Norges teknisk-naturvitenskapelige universitet
Masteroppgave
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Olderøy, Magnus Østgård;
Beckwith, Marianne;
Rrinholt, F P;
Lilledahl, Magnus Borstad;
Sikorski, Pawel;
Brinchmann, Jan E..
(2013)
Identification of functional structures in tissue engineered cartilage: from nm to macro scale.
European Cells and Materials
Konferanseabstract
Tidsskriftspublikasjoner
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Haug, Markus;
Meås, Hany Zakaria;
Beckwith, Marianne Sandvold;
Louet, Claire;
Ryan, Liv;
Hu, Z.;
Landskron, Johannes;
Nordbø, Svein Arne;
Tasken, Kjetil;
Yin, H. H..
(2019)
P1511 - Sensing of HIV-1 nucleic acids by TLR8 in human CD4+ T cells.
European Journal of Immunology
Konferanseabstract
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Beckwith, Kai Sandvold;
Beckwith, Marianne Sandvold;
Ullmann, Sindre;
Sætra, Ragnhild Sofie Ragnhildstveit;
Kim, Hae Lin;
Marstad, Anne;
Åsberg, Signe Elisabeth;
Strand, Trine Aakvik;
Haug, Markus;
Niederweis, Michael.
(2020)
Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection.
Nature Communications
Vitenskapelig artikkel
-
Meås, Hany Zakaria;
Haug, Markus;
Beckwith, Marianne Sandvold;
Louet, Claire;
Ryan, Liv;
Hu, Zhenyi;
Landskron, Johannes;
Nordbø, Svein Arne;
Tasken, Kjetil;
Yin, Hang.
(2020)
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency.
Nature Communications
Vitenskapelig artikkel
-
Magnus Østgård, Olderøy;
Lilledahl, Magnus Borstad;
Beckwith, Marianne;
Melvik, Jan Egil;
Reinholt, Finn P.;
Sikorski, Pawel;
Brinchmann, Jan E..
(2014)
Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels.
PLOS ONE
Vitenskapelig artikkel
-
Beckwith, Marianne;
Beckwith, Kai Sandvold;
Sikorski, Pawel;
Skogaker, Nan Elisabeth Tostrup;
Flo, Trude Helen;
Halaas, Øyvind.
(2015)
Seeing a mycobacterium-infected cell in nanoscale 3D: Correlative imaging by light microscopy and FIB/SEM tomography.
PLOS ONE
Vitenskapelig artikkel
-
Olderøy, Magnus Østgård;
Beckwith, Marianne;
Rrinholt, F P;
Lilledahl, Magnus Borstad;
Sikorski, Pawel;
Brinchmann, Jan E..
(2013)
Identification of functional structures in tissue engineered cartilage: from nm to macro scale.
European Cells and Materials
Konferanseabstract
Studentoppgave eller avhandling
-
Beckwith, Marianne;
Flo, Trude Helen;
Halaas, Øyvind.
(2018)
Targeted correlative light and electron microscopy in the study of host-pathogen interactions.
Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
-
Beckwith, Marianne;
Sikorski, Pawel.
(2013)
Technical Aspects of Ion Milling and Electron Imaging of Epoxy Embedded Samples for FIB/SEM Tomography.
Norges teknisk-naturvitenskapelige universitet
Masteroppgave
Formidling
2022
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Sætra, Ragnhild Sofie Ragnhildstveit; Ullmann, Sindre; Bugge, Marit. (2022) Host-cell killing by Mycobacterium tuberculosis. Invited talk
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Sætra, Ragnhild Sofie Ragnhildstveit; Ullmann, Sindre; Bugge, Marit. (2022) The inner life of a mycobacterium-infected macrophage. Invited talk
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Sætra, Ragnhild Sofie Ragnhildstveit; Ullmann, Sindre; Bugge, Marit. (2022) The Inner Life of Mycobacterium Infected Macrophages. Gordon Research Conference on Lysosomes and Endocytosis 2022: Physiological Adaptations of the Endo-Lysosomal System
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Bugge, Marit; Sætra, Ragnhild Sofie Ragnhildstveit; Ullmann, Sindre. (2022) The inner life of a mycobacterium-infected macrophage. NIAID Invited talk
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Gidon, Alexandre; Mediaas, Sindre Dahl; Sætra, Ragnhild Sofie Ragnhildstveit; Bugge, Marit; Ullmann, Sindre; Åsberg, Signe Elisabeth. (2022) Spatiotemporal Relations of Mycobacteria and Human Macrophages. Department seminar series
2021
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Gidon, Alexandre; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit; Bugge, Marit. (2021) Mycobacterium tuberculosis infection in human macrophages. Department seminar series
2020
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KonferanseposterBeckwith, Marianne Sandvold; Beckwith, Kai Sandvold; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit; Marstad, Anne; Kim, Haelin; Åsberg, Signe Elisabeth; Strand, Trine Aakvik; Haug, Markus; Niederweis, Michael. (2020) Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection. Keystone Symposium Tuberculosis
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KonferanseposterSætra, Ragnhild Sofie Ragnhildstveit; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Ullmann, Sindre; Kim, Haelin; Marstad, Anne; Åsberg, Signe Elisabeth; Strand, Trine Aakvik; Flo, Trude Helen. (2020) Mechanisms in human macrophages infected with Mycobacterium tuberculosis. IBA Annual meeting
2019
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KonferanseforedragHaug, Markus; Meås, Hany Zakaria; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Z.; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, H. H.. (2019) Sensing of HIV-1 by TLR8 in human CD4+ T cells. 45th Annual Meeting of the Scandinavian Society for Immunology (SSI)
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit; Strand, Trine Aakvik; Marstad, Anne; Åsberg, Signe; Stenmark, Harald. (2019) Balancing life and death in mycobacterium-infected macrophages. 2nd International conference on molecular mechanisms of inflammation
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit; Marstad, Anne; Strand, Trine Aakvik; Stenmark, Harald; Åsberg, Signe. (2019) Single-cell dynamics of NLRP3 inflammasome activation and pyroptosis during Mycobacterium tuberculosis infection of human macrophages. IUIS2019 17th International Congress of Immunology
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KonferanseposterUllmann, Sindre; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Åsberg, Signe; Strand, Trine Aakvik; Flo, Trude Helen. (2019) Single-cell Dynamics of Pyroptosis in Mycobacteria Tuberculosis (Mtb) infected human macrophages. NBS Kontaktmøte
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KonferanseposterBeckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit; Marstad, Anne; Åsberg, Signe; Strand, Trine Aakvik; Flo, Trude Helen. (2019) Plasma membrane damage during Mycobacterium tuberculosis infection. The 4th Turning the Tide of Antimicrobial resistance meeting
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KonferanseposterUllmann, Sindre; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Sætra, Ragnhild Sofie Ragnhildstveit; Marstad, Anne; Åsberg, Signe; Strand, Trine Aakvik; Flo, Trude Helen. (2019) Catching the moment - Correlative Light Electron Microscopy (CLEM) to study hostpathogen interactions in single cells, at ultimate spatial and temporal resolutions. Conference on Molecular Mechanisms of Inflammation
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KonferanseposterHaug, Markus; Meås, Hany Zakaria; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Z.; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, H. H.. (2019) Sensing of HIV-1 nucleic acids by TLR8 in human CD4+ T cells. 17th Congress of the International Union of Immunological Societies (IUIS)
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KonferanseforedragMeås, Hany Zakaria; Haug, Markus; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Z.; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, H. H.. (2019) Sensing of HIV-1 by TLR8 activates human T cells and reverses latency. International Conference on Molecular Mechanisms of Inflammation
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KonferanseposterUllmann, Sindre; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Sætra, Ragnhild Sofie Ragnhildstveit; Marstad, Anne; Strand, Trine Aakvik; Flo, Trude Helen. (2019) Catching the moment - Correlative Light Electron Microscopy (CLEM) to study hostpathogen interactions in single cells, at ultimate spatial and temporal resolutions. The 4th Turning the Tide of Antimicrobial resistance meeting
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KonferanseposterUllmann, Sindre; Sporsheim, Bjørnar; Egeberg, Kjartan Wøllo; Beckwith, Marianne Sandvold; Beckwith, Kai Sandvold; Sætra, Ragnhild Sofie Ragnhildstveit; Åsberg, Signe; Strand, Trine Aakvik; Flo, Trude Helen. (2019) Correlative light-electron microscopy investigations of single-cell dynamics in Mycobacteria tuberculosis infected human macrophages. Seeing is Believing - Imaging the Molecular Processes of Life
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Gidon, Alexandre; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit. (2019) Plasma membrane damage by Mycobacterium tuberculosis induce inflammasome activation and pyroptosis in host macrophages. International Symposium on Discovery of Actionable Targets in Infectious Diseases
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KonferanseposterMeås, Hany Zakaria; Haug, Markus; Beckwith, Marianne; Louet, Claire; Ryan, Liv; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Damås, Jan Kristian; Flo, Trude Helen. (2019) Sensing of HIV-1 by TLR8 activates human T cells and reverses Latency. Norsk Biokjemisk Selskap Kontaktmøte 2019
2018
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KonferanseposterBeckwith, Marianne; Beckwith, Kai Sandvold; Ullmann, Sindre; Åsberg, Signe; Strand, Trine Aakvik; Flo, Trude Helen. (2018) Single-cell dynamics of pyroptosis in M. tuberculosis infected macrophages. EMBO workshop: The inflammasomes
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KonferanseposterMeås, Hany Zakaria; Haug, Markus; Beckwith, Marianne; Louet, Claire; Ryan, Liv; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Damås, Jan Kristian; Flo, Trude Helen. (2018) Sensing of HIV-1 by TLR8 activates human T cells and reverses Latency. Keystone HIV and Co-Infections: Pathogenesis, Inflammation and Persistence (X8)
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KonferanseforedragFlo, Trude Helen; Beckwith, Marianne; Meås, Hany Zakaria; Haug, Markus; Damås, Jan Kristian; Ryan, Liv; Louet, Claire. (2018) Sensing of HIV-1 by TLR8 activates human T cells and reverses latency. PhD defense
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KonferanseforedragFlo, Trude Helen; Beckwith, Kai Sandvold; Beckwith, Marianne. (2018) Single-cell dynamics of pyroptosis in Mycobacterium tuberculosis infected macrophages. PhD defense
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KonferanseforedragFlo, Trude Helen; Beckwith, Marianne; Beckwith, Kai Sandvold; Ullmann, Sindre; Åsberg, Signe; Marstad, Anne. (2018) Single-cell dynamics of pyroptosis in Mycobacterium tuberculosis infected macrophages. 51st Annual Meeting Society for Leukocyte Biology & International Endotoxin and Innate Immunity Society
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KonferanseforedragFlo, Trude Helen; Beckwith, Marianne; Beckwith, Kai Sandvold. (2018) Single-cell dynamics of pyroptosis in Mycobacterium tuberculosis infected macrophages. TOLL2018: Editing Innate Immunity
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ForedragBeckwith, Marianne. (2018) Tailor made aclar for correlative imaging by light microscopy and FIB-SEM tomography. EMBL seminar
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KonferanseposterBeckwith, Kai Sandvold; Beckwith, Marianne; Ullmann, Sindre; Åsberg, Signe; Flo, Trude Helen. (2018) Single-cell dynamics of pyroptosis in M. Tuberculosis infected macrophages. EMBL Conference: From Images to Knowledge with ImageJ & Friends
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ForedragBeckwith, Kai Sandvold; Beckwith, Marianne; Ullmann, Sindre; Åsberg, Signe; Sætra, Ragnhild Sofie Ragnhildstveit; Strand, Trine Aakvik; Flo, Trude Helen. (2018) Damage and repair of host cell membranes during M. Tuberculosis infection. EMBL seminar
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KonferanseforedragBeckwith, Kai Sandvold; Beckwith, Marianne; Ullmann, Sindre; Åsberg, Signe; Strand, Trine Aakvik; Flo, Trude Helen. (2018) SINGLE-CELL DYNAMICS OF PYROPTOSIS IN M. TUBERCULOSIS INFECTED MACROPHAGES. Annual meeting Norwegian Research School for Infection biology and antimicrobials
2017
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KonferanseforedragFlo, Trude Helen; Beckwith, Marianne; Beckwith, Kai Sandvold. (2017) The cell biology of Mycobacterium tuberculosis induced inflammasome activation and killing of host macrophages. The 35th annual meeeting Norwegian Society for Immunology
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KonferanseposterBeckwith, Marianne; Beckwith, Kai Sandvold; Strand, Trine Aakvik; Flo, Trude Helen. (2017) In situ imaging of pyroptosis caused by Mycobacterium tuberculosis. Keystone X5: From Innate Immunity to Inflammatory Disease
2016
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Konferanseforedrag
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KonferanseforedragBeckwith, Marianne. (2016) Corellative 3D light and electron microscopy - M. Avium-infected macrophages. SCANDEM 2016
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KonferanseforedragBeckwith, Marianne. (2016) Intracellular life in nanoscale 3D - Correlative imaging by light microscopy and FIB/SEM tomography. IBA forskerskole kick-off
2014
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KonferanseforedragBeckwith, Marianne. (2014) Aclar microwells for Correlative Imaging of Mycobacterium infected Macrophages by CLSM and FIB/SEM. SCANDEM 2014
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KonferanseforedragBeckwith, Marianne. (2014) Correlative Imaging of Mycobacterium infected Macrophages by CLSM and FIB/SEM - A system for high resolution 3D investigation. CMIC seminar
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ForedragBeckwith, Marianne. (2014) Du tror det når du får se det: en infeksjon i tre dimensjoner. Forsker grand prix Trondheim
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KonferanseforedragBeckwith, Marianne. (2014) Optimizing Correlative Imaging of Mycobacterium-infected Macrophages by CLSM and FIB/SEM. Norwegian Biochemical Society (NBS) Contact Meeting 2014
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KonferanseposterBeckwith, Marianne; Beckwith, Kai Sandvold; Sikorski, Pawel; Flo, Trude Helen; Halaas, Øyvind. (2014) Correlative imaging by light microscopy and FIB/SEM tomography. NTNU NanoLab 10 Year Anniversary
2013
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ForedragBeckwith, Marianne. (2013) Electron Microscopy Techniques for Biological Applications. Seminar on Biological TEM