Marit Otterlei
Om
Curriculum:
- 2010- CSO, APIM Therapeutics AS, Trondheim (deltid)
- 2003- Professor, Fakultet for medisin og helsevitenskap, Institutt for klinisk og molekylær medisin (IKOM), NTNU, Norges teknisk-naturvitenskapelige universitet, Trondheim (hovedstilling).
- Gjesteforsker ved Centre de Rescherche en Cancerologies de Marseille (CRCM), Frankrike (vårsemester) and Institutt for biologi, Universitetet i København, Danmark (høstsemester), 2019.
- Gjesteforsker ved Laboratory of Molecular Gerontology, National Institute on Aging, National Institute of Health, Baltimore, USA, 2002-2003.
- Startet egen forskningsgruppe i 2002 ved institutt for kreftforskning NTNU etter å ha fått karrierestipend fra forskningsrådet på prosjektet “Replication associated DNA repair”, 2002-2006.
- Førsteamanuensis II, UNIGEN, Center for Molekylærbiologi and Institutt for kreftforskning, Universitetet i Trondheim (UNIT) (nå NTNU), 1988-2002.
- Postdoktor, DNA reparasjon, UNIGEN, Senter for molekylærbiologi, UNIT, Trondheim, 1994-2001.
- PhD (Dr.ing) innenfor medfødt immunitet ved Institutt for Bioteknologi og Institutt for kreftforskning, Norges Tekniske Høyskole (NTH)/ UNIT (nå NTNU), 1994.
- MSc (Siv.ing), Institutt for Bioteknologi, NTH (nå NTNU), 1988.
Proteiner i DNA-sliding clamp-familien er strukturelt konserverte fra bakterier til mennesker. Disse proteinene har en nøkkelrolle i DNA-replikasjon og DNA reparasjon. Nyere forskning, blant annet fra Otterleis forskningsgruppe, har vist at de også deltar i andre cellulære prosesser som er avgjørende for cellenes evne til å håndtere stress. Denne sentrale funksjonen gjør dem interessante som målproteiner i behandling av både kreft og infeksjoner.
Basert på oppdagelsen av et nytt bindingsmotiv for den humane DNA-sliding clampen PCNA, som har fått navnet APIM, ble NTNU-spin-off-selskapet APIM Therapeutics etablert i 2009. Selskapet utvikler et peptid (et lite protein) til bruk i kreftbehandling, som inneholder dette bindingsmotivet. Otterlei er vitenskapelig ansvarlig i selskapet (CSO) ) (https://www.apimtherapeutics.com/). Peptidet har vist seg å være godt tolerert og ha en kreftstabiliserende effekt i mennesker i et fase I-studie, og videre fase II-studier er under planlegging.
Under laboratoriestudier av peptidet oppstod det uventet en bakterieinfeksjon i cellekulturene. Overraskende nok viste det seg at de APIM-inneholdende peptidene også antibakterielle effekter. Noen av disse effekten skyldes binding av APIM også til den bakterielle DNA-sliding clampen (beta-clampen). Vi har utviklet nye bedre antibakterielle peptider og vist at disse påvirker flere ulike mekanismer i bakterier, inkludert cellemembranen, proteintranslasjon og bakteriens evne til mutasjon og replikasjon. Gruppens fokus er å utvikle antimikrobielle peptider som angriper bakterier på nye måter – som grunnlag for neste generasjons antibiotika.
Vi arbeider også videre med å forstå hvordan PCNA, gjennom interaksjoner med proteiner som inneholder APIM, regulerer cellulære stressresponser som er viktige for blant annet immunregulering, inflammasjon og cellevekst.
For vitenskapelige detaljer, se engelsk versjon.
Publikasjoner
2025
-
Bergum, Olaug Elisabeth Torheim;
Otterlei, Marit;
Bruheim, Per.
(2025)
Multi-omics analysis of bacterial stress responses to identify antibiotic mode of action.
NTNU Norges teknisk-naturvitenskapelige universitet
NTNU Norges teknisk-naturvitenskapelige universitet
Doktorgradsavhandling
-
Simonsen, Signe;
Larsen, Fia B.;
Søgaard, Caroline Krogh;
Jonsson, Nicolas;
Lindorff-Larsen, Kresten;
Bruheim, Per.
(2025)
Extreme multivalency and a composite short linear motif facilitate PCNA-binding, localisation and abundance of p21 (CDKN1A).
The FEBS Journal
Vitenskapelig artikkel
2024
-
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2024)
Targeting proliferating cell nuclear antigen (PCNA) for cancer therapy.
Advances in Pharmacology
Vitenskapelig artikkel
-
Simonsen, Signe;
Søgaard, Caroline Krogh;
Olsen, Johan G.;
Otterlei, Marit;
Kragelund, Birthe B..
(2024)
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery.
Cellular and Molecular Life Sciences (CMLS)
Vitenskapelig oversiktsartikkel/review
-
Olaisen, Camilla;
Røst, Lisa M.;
Sharma, Animesh;
Søgaard, Caroline Krogh;
Khong, Tiffany;
Berg, Sigrid Ravn.
(2024)
Multiple Myeloma Cells with Increased Proteasomal and ER Stress Are Hypersensitive to ATX-101, an Experimental Peptide Drug Targeting PCNA.
Cancers
Vitenskapelig artikkel
-
Otterlei, Marit;
Haugan, Maria Schei;
Bjørås, Magnar;
Müller, Fredrik.
(2024)
Hva bør Norge bidra med for å redusere antibiotikaresistens-krisen?.
Dagens medisin
Leserinnlegg
-
Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2024)
tRNA-Derived Fragments as Biomarkers in Bladder Cancer.
Cancers
Vitenskapelig artikkel
-
Singleton, Amanda Holstad;
Otterlei, Marit.
(2024)
Nytt verktøy i jakten på nye antibiotikakandidater.
Bioingeniøren
Populærvitenskapelig artikkel
-
Otterlei, Marit;
Huse, Kanutte;
Rye, Inga Hansine.
(2024)
The Tumor Immune Microenvironment in Breast Cancer Progression.
Acta Oncologica
Vitenskapelig oversiktsartikkel/review
-
Gravina, Giovanni Luca;
Colapietro, Alessandro;
Mancini, Andrea;
Rossetti, Alessandra;
Martellucci, Stefano;
Ventura, Luca.
(2024)
Correction to: ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma (Cancers, (2022), 14, 2, (289), 10.3390/cancers14020289).
Cancers
Errata
-
Bergum, Olaug Elisabeth Torheim;
Singleton, Amanda Holstad;
Røst, Lisa Marie Ivarsdatter;
Bodein, Antoine;
Scott-Boyer, Marie-Pier;
Rye, Morten Beck.
(2024)
SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated.
Frontiers in Microbiology
Vitenskapelig artikkel
2023
-
Rocque, Mariève;
Leipart, Vilde;
Singh, Ashish Kumar;
Mur, Pilar;
Olsen, Maren Fridtjofsen;
Engebretsen, Lars Fredri.
(2023)
Characterization of POLE c.1373A > T p.(Tyr458Phe), causing high cancer risk.
Molecular Genetics and Genomics
Vitenskapelig artikkel
-
Singleton, Amanda Holstad;
Bergum, Olaug Elisabeth Torheim;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen.
(2023)
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates.
Frontiers in Microbiology
Vitenskapelig artikkel
2022
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene
Vitenskapelig artikkel
-
Lemech, Charlotte Rose;
Kichenadasse, Ganessan;
Marschner, Jens-Peter;
Alevizopoulos, Konstantinos;
Otterlei, Marit;
Millward, Michael.
(2022)
ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study.
Oncogene
Vitenskapelig artikkel
-
Gravina, Giovanni Luca;
Colapietro, Alessandro;
Andrea, Mancini;
Rossetti, Alessandra;
Martelucci, Stefano;
Ventura, Luca.
(2022)
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma.
Cancers
Vitenskapelig artikkel
-
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics
Vitenskapelig artikkel
2021
-
Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2021)
Differentially expressed extracellular vesicle-contained micrornas before and after transurethral resection of bladder tumors.
Current Issues in Molecular Biology
Vitenskapelig artikkel
-
Ræder, Synnøve Brandt;
Sandbakken, Erik Thorvaldsen;
Nepal, Anala;
Løseth, Kirsti;
Bergh, Kåre;
Witsø, Eivind.
(2021)
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo.
Frontiers in Microbiology
Vitenskapelig artikkel
-
Frimodt-Møller, Jakob;
Koulouktsis, Andreas;
Charbon, Godefroid;
Otterlei, Marit;
Nielsen, Peter E.;
Løbner-Olesen, Anders.
(2021)
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli.
Molecular Therapy Nucleic Acids
Vitenskapelig artikkel
-
Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules
Vitenskapelig artikkel
-
Nepal, Anala;
Ræder, Synnøve Brandt;
Søgaard, Caroline Krogh;
Haugan, Maria Schei;
Otterlei, Marit.
(2021)
Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization.
Frontiers in Microbiology
Vitenskapelig artikkel
-
Blindheim, Fredrik Heen;
Olsen, Cecilie Elisabeth;
Søgaard, Caroline Krogh;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2021)
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents.
European Journal of Organic Chemistry
Vitenskapelig artikkel
2020
-
Røst, Lisa Marie;
Otterlei, Marit;
Bruheim, Per.
(2020)
Targeted Mass Spectrometric Metabolite Profiling for Studies of Central Carbon Metabolism.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Doktorgradsavhandling
-
Nedal, Aina;
Ræder, Synnøve Brandt;
Dalhus, Bjørn;
Helgesen, Emily;
Forstrøm, Rune Johansen;
Lindland, Kim.
(2020)
Peptides containing the PCNA interacting motif APIM
bind to the beta-clamp and inhibit bacterial growth and
mutagenesis.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Seelinger, Mareike;
Otterlei, Marit.
(2020)
Helicase-Like Transcription Factor HLTF and E3
Ubiquitin Ligase SHPRH Confer DNA Damage
Tolerance through Direct Interactions
with Proliferating Cell Nuclear Antigen (PCNA).
International Journal of Molecular Sciences
Vitenskapelig artikkel
-
Seelinger, Mareike;
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2020)
The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type.
Biomolecules
Vitenskapelig artikkel
2019
-
Prestel, Andreas;
Wichmann, Nanna;
Martins, Joao M;
Marabini, Riccardo;
Kassem, Noah;
Broendum, Sebastian S.
(2019)
The PCNA interaction motifs revisited: thinking outside the PIP-box.
Cellular and Molecular Life Sciences (CMLS)
Vitenskapelig artikkel
-
Søgaard, Caroline Krogh;
Nepal, Anala;
Petrovic, Voin;
Sharma, Animesh;
Liabakk, Nina-Beate;
Steigedal, Tonje S..
(2019)
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy.
OncoTarget
Vitenskapelig artikkel
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Vitenskapelig artikkel
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Vitenskapelig artikkel
2018
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients
Vitenskapelig artikkel
-
Ræder, Synnøve Brandt;
Nepal, Anala;
Bjørås, Karine;
Seelinger, Mareike;
Kolve, Rønnaug Steen;
Nedal, Aina.
(2018)
APIM-mediated REV3L?PCNA interaction important for error free TLS over UV-induced DNA lesions in human cells.
International Journal of Molecular Sciences
Vitenskapelig artikkel
-
Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget
Vitenskapelig artikkel
-
Søgaard, Caroline Danielsen;
Moestue, Siver Andreas;
Rye, Morten Beck;
Kim, Jana;
Nepal, Anala;
Liabakk, Nina-Beate.
(2018)
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
OncoTarget
Vitenskapelig artikkel
-
Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio
Vitenskapelig artikkel
2017
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik.
(2017)
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel.
Data in Brief
Vitenskapelig artikkel
-
Sousa, Mirta;
Bjørås, Karine;
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Otterlei, Marit.
(2017)
P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.
Scientific Reports
Vitenskapelig artikkel
-
Bjørås, Karine;
Sousa, Mirta;
Sharma, Animesh;
Fonseca, Davi de Miranda;
Søgaard, Caroline Danielsen;
Bjørås, Magnar.
(2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik.
(2017)
On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay.
Analytical Biochemistry
Vitenskapelig artikkel
2016
-
Marstad, Anne;
Landsverk, Ole J. B.;
Strømme, Olaf;
Otterlei, Marit;
Collas, Philippe;
Sundan, Anders.
(2016)
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.
The FEBS Journal
Vitenskapelig artikkel
2015
-
Olaisen, Camilla;
Müller, Rebekka;
Nedal, Aina;
Otterlei, Marit.
(2015)
PCNA-interacting peptides reduce Akt phophorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.
Cellular Signalling
Vitenskapelig artikkel
2014
-
Baglo, Yan;
Hagen, Lars;
Høgset, Anders;
Drabløs, Finn;
Otterlei, Marit;
Gederaas, Odrun Arna.
(2014)
Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.
BioMed Research International
Vitenskapelig artikkel
-
Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology
Vitenskapelig artikkel
2013
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Vitenskapelig artikkel
-
Müller, Rebekka;
Misund, Kristine;
Holien, Toril;
Bachke, Siri;
Gilljam, Karin Margaretha;
Våtsveen, Thea Kristin.
(2013)
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells.
PLOS ONE
Vitenskapelig artikkel
2012
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Gilljam, Karin Margaretha;
Torseth, Kathrin;
Wilson, David M.;
Akbari, Mansour.
(2012)
The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1.
DNA Repair
Vitenskapelig artikkel
-
Otterlei, Marit;
Müller, R.;
Gilljam, Karin Margaretha;
Holien, Toril;
Midsund, K.;
Vatsveen, TK.
(2012)
PEPTIDES COMPRISING THE NOVEL PCNA INTERACTING SEQUENCE APIM, INCREASES THE CYTOTOXICITY OF CHEMOTHERAPEUTIC DRUGS BY IMPAIRING THE CELLS DEFENSE MECHANISMS.
Annals of Oncology
Sammendrag/Abstract
-
Bjørnstad, Linn;
Meza, Trine Johansen;
Otterlei, Marit;
Olafsrud, Solveig Mjelstad;
Meza-Zepeda, Leonardo Andrés;
Falnes, Pål.
(2012)
Human ALKBH4 Interacts with Proteins Associated with Transcription.
PLOS ONE
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Müller, Rebekka;
Liabakk, Nina-Beate;
Otterlei, Marit.
(2012)
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.
PLOS ONE
Vitenskapelig artikkel
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Akbari, Mansour;
Otterlei, Marit.
(2012)
X-ray repair cross complementing protein 1 in base excision repair.
International Journal of Molecular Sciences
Vitenskapelig oversiktsartikkel/review
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Vitenskapelig artikkel
2011
-
Alevizopoulos, K;
Otterlei, Marit.
(2011)
ATX-101, a novel APIM-motif comprising peptide drug potentiates the action of several chemotherapeutic drugs by blocking the interaction between PCNA and key proteins involved in DNA repair and cell cycle control.
Annals of Oncology
Sammendrag/Abstract
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods
Vitenskapelig artikkel
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Sundheim, Ottar;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2011)
XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage.
Environmental and Molecular Mutagenesis
Vitenskapelig artikkel
2010
-
Arum, Carl-Jørgen;
Kodama, Yosuke;
Rolim, Natale Pinheiro Lage;
Widerøe, Marius;
Anderssen, Endre;
Viset, Trond.
(2010)
A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma.
World Journal of Urology
Vitenskapelig artikkel
-
Akbari, Mansour;
Solvang-Garten, Karin;
Hanssen-Bauer, Audun;
Lieske, Nora V.;
Pettersen, Henrik P Sahlin;
Pettersen, Grete Klippenvåg.
(2010)
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Sammendrag/Abstract
2009
-
Akbari, Mansour;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Liabakk, Nina-Beate;
Otterlei, Marit;
Krokan, Hans Einar.
(2009)
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.
DNA Repair
Vitenskapelig artikkel
-
Müller, Rebekka;
Otterlei, Marit.
(2009)
APIM's mechanisms of action.
Norwegian University of Science and Technology, Faculty of Medicine
Norwegian University of Science and Technology, Faculty of Medicine
Mastergradsoppgave
-
Langevin, C;
Maidou-Peindara, P;
Aas, Per Arne;
Jacquot, G;
Otterlei, Marit;
Slupphaug, Geir.
(2009)
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect.
Journal of Virology
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel/review
2008
-
Akbari, Mansour;
Visnes, Torkild;
Krokan, Hans Einar;
Otterlei, Marit.
(2008)
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
DNA Repair
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
2007
-
Sterten, Heidi;
Krøkje, Åse;
Otterlei, Marit;
Slupphaug, Geir.
(2007)
Ekspresjon, rensing og funksjonelle studier av rekombinant humant replikasjonsprotein A (RPA).
NTNU
NTNU
Mastergradsoppgave
-
Akbari, Mansour;
Otterlei, Marit;
Pena-Diaz, J;
Krokan, Hans Einar.
(2007)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Vitenskapelig artikkel
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Sammendrag/Abstract
2006
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Krokan, Hans Einar.
(2006)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Vitenskapelig artikkel
-
Pettersen, Grete Klippenvåg;
Otterlei, Marit.
(2006)
DNA repair complexes.
Privat
Privat
Mastergradsoppgave
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Vitenskapelig oversiktsartikkel/review
-
Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy.
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Sammendrag/Abstract
2005
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
-
Pohler, JRG;
Otterlei, Marit;
Warbrick, E.
(2005)
An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit.
BMC Molecular Biology
Vitenskapelig artikkel
-
Luna, Gomez Luisa;
Luna, L;
Rolseth, V;
Hildrestrand, GA;
Otterlei, Marit;
Dantzer, F.
(2005)
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys(326) polymorphic variant.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2004
-
Opresko, PL;
Otterlei, Marit;
Graakjaer, J;
Bruheim, P;
Dawut, L;
Kolvraa, S.
(2004)
The Werner syndrome helicase and exonuclease cooperate to resolve telometric D-loops in a manner regulated by TRF1 and TRF2.
Molecular Cell
Vitenskapelig artikkel
-
Sharma, S;
Otterlei, Marit;
Sommers, JA;
Driscoll, HC;
Dianov, GL;
Kao, HI.
(2004)
WRN helicase and Flap endonuclease 1 forms a complex upon replication arrest and together process branch-migrating DNA structures associated with the replication fork.
Molecular Biology of the Cell
Vitenskapelig artikkel
-
Fan, JS;
Otterlei, Marit;
Wong, HK;
Tomkinson, AE;
Wilson, DM.
(2004)
XRCC1 co-localizes and physically interacts with PCNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
2003
-
Bayton, Kathy;
Otterlei, Marit;
Bjørås, Magnar;
Kobbe, C von;
Bohr, V.A.;
Seeberg, Erling Christen.
(2003)
WRN interacts physically and functionally with the recombination mediator protein RAD52.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Baynton, Kathy;
Otterlei, Marit;
Bjørås, M.;
Kobbe, Cayetano von;
Bohr, Vilhelm;
Seeberg, E..
(2003)
WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*.
JBC Papers in Press
Vitenskapelig artikkel
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
2002
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
2001
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
2000
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, Hilde;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair of DNA in mammalian cells.
FEBS Letters
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, H.;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair in mammalian cells.
FEBS Letters
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
1999
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
-
Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal
Vitenskapelig artikkel
1998
-
Jørgensen, Kjersti;
Otterlei, Marit.
(1998)
Human uracil DNA glycosylase. Egenskaper til enzymer med og uten presekvens.
[Mangler utgivernavn]
[Mangler utgivernavn]
Mastergradsoppgave
-
Bharati, S.;
Krokan, Hans Einar;
Kristiansen, L;
Otterlei, Marit;
Slupphaug, Geir.
(1998)
Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
Plenum Press
Plenum Press
Fagbok
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Mekanismer for intracellulær sortering av UNG-proteiner studert ved molekylærbiologiske og biofysiske metoder.
[Mangler utgivernavn]
[Mangler utgivernavn]
Rapport
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Sekvenser i UNG2 som er viktige for UDG-aktivitet, Mg2eion stimulering og intracellulær sortering.
[Mangler utgivernavn]
[Mangler utgivernavn]
Rapport
-
Otterlei, Marit;
Haug, T.;
Nagelhus, T.A;
Slupphaug, Geir;
Lindmo, T.;
Krokan, Hans Einar.
(1998)
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
1997
-
Krokan, Hans Einar;
Standal, Rune;
Bharati, Sangeeta;
Otterlei, Marit;
Haug, Terje;
Slupphaug, Geir.
(1997)
Uracil in DNA and the family of concerved uracil DNA glycosylases.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Nilsen, H.;
Otterlei, Marit;
Haug, T.;
Solum, K.;
Nagelhus, T.A;
Skorpen, Frank.
(1997)
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Nagelhus, T.;
Haug, T.;
Singh, K.K.;
Keshav, K.F.;
Skorpen, Frank;
Bharati, S..
(1997)
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A.
Journal of Biological Chemistry
Vitenskapelig artikkel
1995
-
Skjåk-Bræk, Gudmund;
Espevik, Terje;
Otterlei, Marit;
Smidsrød, Olav;
Soon-Shiong, P..
(1995)
Homologous guluronic acid alginate coating composition for in vivo application and implantation and method using the same.
[Mangler utgivernavn]
[Mangler utgivernavn]
Rapport
Tidsskriftspublikasjoner
-
Simonsen, Signe;
Larsen, Fia B.;
Søgaard, Caroline Krogh;
Jonsson, Nicolas;
Lindorff-Larsen, Kresten;
Bruheim, Per.
(2025)
Extreme multivalency and a composite short linear motif facilitate PCNA-binding, localisation and abundance of p21 (CDKN1A).
The FEBS Journal
Vitenskapelig artikkel
-
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2024)
Targeting proliferating cell nuclear antigen (PCNA) for cancer therapy.
Advances in Pharmacology
Vitenskapelig artikkel
-
Simonsen, Signe;
Søgaard, Caroline Krogh;
Olsen, Johan G.;
Otterlei, Marit;
Kragelund, Birthe B..
(2024)
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery.
Cellular and Molecular Life Sciences (CMLS)
Vitenskapelig oversiktsartikkel/review
-
Olaisen, Camilla;
Røst, Lisa M.;
Sharma, Animesh;
Søgaard, Caroline Krogh;
Khong, Tiffany;
Berg, Sigrid Ravn.
(2024)
Multiple Myeloma Cells with Increased Proteasomal and ER Stress Are Hypersensitive to ATX-101, an Experimental Peptide Drug Targeting PCNA.
Cancers
Vitenskapelig artikkel
-
Otterlei, Marit;
Haugan, Maria Schei;
Bjørås, Magnar;
Müller, Fredrik.
(2024)
Hva bør Norge bidra med for å redusere antibiotikaresistens-krisen?.
Dagens medisin
Leserinnlegg
-
Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2024)
tRNA-Derived Fragments as Biomarkers in Bladder Cancer.
Cancers
Vitenskapelig artikkel
-
Singleton, Amanda Holstad;
Otterlei, Marit.
(2024)
Nytt verktøy i jakten på nye antibiotikakandidater.
Bioingeniøren
Populærvitenskapelig artikkel
-
Otterlei, Marit;
Huse, Kanutte;
Rye, Inga Hansine.
(2024)
The Tumor Immune Microenvironment in Breast Cancer Progression.
Acta Oncologica
Vitenskapelig oversiktsartikkel/review
-
Gravina, Giovanni Luca;
Colapietro, Alessandro;
Mancini, Andrea;
Rossetti, Alessandra;
Martellucci, Stefano;
Ventura, Luca.
(2024)
Correction to: ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma (Cancers, (2022), 14, 2, (289), 10.3390/cancers14020289).
Cancers
Errata
-
Bergum, Olaug Elisabeth Torheim;
Singleton, Amanda Holstad;
Røst, Lisa Marie Ivarsdatter;
Bodein, Antoine;
Scott-Boyer, Marie-Pier;
Rye, Morten Beck.
(2024)
SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated.
Frontiers in Microbiology
Vitenskapelig artikkel
-
Rocque, Mariève;
Leipart, Vilde;
Singh, Ashish Kumar;
Mur, Pilar;
Olsen, Maren Fridtjofsen;
Engebretsen, Lars Fredri.
(2023)
Characterization of POLE c.1373A > T p.(Tyr458Phe), causing high cancer risk.
Molecular Genetics and Genomics
Vitenskapelig artikkel
-
Singleton, Amanda Holstad;
Bergum, Olaug Elisabeth Torheim;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen.
(2023)
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates.
Frontiers in Microbiology
Vitenskapelig artikkel
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene
Vitenskapelig artikkel
-
Lemech, Charlotte Rose;
Kichenadasse, Ganessan;
Marschner, Jens-Peter;
Alevizopoulos, Konstantinos;
Otterlei, Marit;
Millward, Michael.
(2022)
ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study.
Oncogene
Vitenskapelig artikkel
-
Gravina, Giovanni Luca;
Colapietro, Alessandro;
Andrea, Mancini;
Rossetti, Alessandra;
Martelucci, Stefano;
Ventura, Luca.
(2022)
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma.
Cancers
Vitenskapelig artikkel
-
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics
Vitenskapelig artikkel
-
Strømme, Olaf;
Heck, Kathleen;
Brede, Gaute;
Lindholm, Håvard Takle;
Otterlei, Marit;
Arum, Carl-Jørgen.
(2021)
Differentially expressed extracellular vesicle-contained micrornas before and after transurethral resection of bladder tumors.
Current Issues in Molecular Biology
Vitenskapelig artikkel
-
Ræder, Synnøve Brandt;
Sandbakken, Erik Thorvaldsen;
Nepal, Anala;
Løseth, Kirsti;
Bergh, Kåre;
Witsø, Eivind.
(2021)
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo.
Frontiers in Microbiology
Vitenskapelig artikkel
-
Frimodt-Møller, Jakob;
Koulouktsis, Andreas;
Charbon, Godefroid;
Otterlei, Marit;
Nielsen, Peter E.;
Løbner-Olesen, Anders.
(2021)
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli.
Molecular Therapy Nucleic Acids
Vitenskapelig artikkel
-
Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules
Vitenskapelig artikkel
-
Nepal, Anala;
Ræder, Synnøve Brandt;
Søgaard, Caroline Krogh;
Haugan, Maria Schei;
Otterlei, Marit.
(2021)
Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization.
Frontiers in Microbiology
Vitenskapelig artikkel
-
Blindheim, Fredrik Heen;
Olsen, Cecilie Elisabeth;
Søgaard, Caroline Krogh;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2021)
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents.
European Journal of Organic Chemistry
Vitenskapelig artikkel
-
Nedal, Aina;
Ræder, Synnøve Brandt;
Dalhus, Bjørn;
Helgesen, Emily;
Forstrøm, Rune Johansen;
Lindland, Kim.
(2020)
Peptides containing the PCNA interacting motif APIM
bind to the beta-clamp and inhibit bacterial growth and
mutagenesis.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Seelinger, Mareike;
Otterlei, Marit.
(2020)
Helicase-Like Transcription Factor HLTF and E3
Ubiquitin Ligase SHPRH Confer DNA Damage
Tolerance through Direct Interactions
with Proliferating Cell Nuclear Antigen (PCNA).
International Journal of Molecular Sciences
Vitenskapelig artikkel
-
Seelinger, Mareike;
Søgaard, Caroline Krogh;
Otterlei, Marit.
(2020)
The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type.
Biomolecules
Vitenskapelig artikkel
-
Prestel, Andreas;
Wichmann, Nanna;
Martins, Joao M;
Marabini, Riccardo;
Kassem, Noah;
Broendum, Sebastian S.
(2019)
The PCNA interaction motifs revisited: thinking outside the PIP-box.
Cellular and Molecular Life Sciences (CMLS)
Vitenskapelig artikkel
-
Søgaard, Caroline Krogh;
Nepal, Anala;
Petrovic, Voin;
Sharma, Animesh;
Liabakk, Nina-Beate;
Steigedal, Tonje S..
(2019)
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy.
OncoTarget
Vitenskapelig artikkel
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Vitenskapelig artikkel
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Vitenskapelig artikkel
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients
Vitenskapelig artikkel
-
Ræder, Synnøve Brandt;
Nepal, Anala;
Bjørås, Karine;
Seelinger, Mareike;
Kolve, Rønnaug Steen;
Nedal, Aina.
(2018)
APIM-mediated REV3L?PCNA interaction important for error free TLS over UV-induced DNA lesions in human cells.
International Journal of Molecular Sciences
Vitenskapelig artikkel
-
Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget
Vitenskapelig artikkel
-
Søgaard, Caroline Danielsen;
Moestue, Siver Andreas;
Rye, Morten Beck;
Kim, Jana;
Nepal, Anala;
Liabakk, Nina-Beate.
(2018)
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.
OncoTarget
Vitenskapelig artikkel
-
Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio
Vitenskapelig artikkel
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik.
(2017)
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel.
Data in Brief
Vitenskapelig artikkel
-
Sousa, Mirta;
Bjørås, Karine;
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Otterlei, Marit.
(2017)
P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.
Scientific Reports
Vitenskapelig artikkel
-
Bjørås, Karine;
Sousa, Mirta;
Sharma, Animesh;
Fonseca, Davi de Miranda;
Søgaard, Caroline Danielsen;
Bjørås, Magnar.
(2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Petrovic, Voin;
Olaisen, Camilla;
Sharma, Animesh;
Nepal, Anala;
Bugge, Steffen;
Sundby, Eirik.
(2017)
On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay.
Analytical Biochemistry
Vitenskapelig artikkel
-
Marstad, Anne;
Landsverk, Ole J. B.;
Strømme, Olaf;
Otterlei, Marit;
Collas, Philippe;
Sundan, Anders.
(2016)
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.
The FEBS Journal
Vitenskapelig artikkel
-
Olaisen, Camilla;
Müller, Rebekka;
Nedal, Aina;
Otterlei, Marit.
(2015)
PCNA-interacting peptides reduce Akt phophorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.
Cellular Signalling
Vitenskapelig artikkel
-
Baglo, Yan;
Hagen, Lars;
Høgset, Anders;
Drabløs, Finn;
Otterlei, Marit;
Gederaas, Odrun Arna.
(2014)
Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.
BioMed Research International
Vitenskapelig artikkel
-
Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology
Vitenskapelig artikkel
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Vitenskapelig artikkel
-
Müller, Rebekka;
Misund, Kristine;
Holien, Toril;
Bachke, Siri;
Gilljam, Karin Margaretha;
Våtsveen, Thea Kristin.
(2013)
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells.
PLOS ONE
Vitenskapelig artikkel
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Gilljam, Karin Margaretha;
Torseth, Kathrin;
Wilson, David M.;
Akbari, Mansour.
(2012)
The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1.
DNA Repair
Vitenskapelig artikkel
-
Otterlei, Marit;
Müller, R.;
Gilljam, Karin Margaretha;
Holien, Toril;
Midsund, K.;
Vatsveen, TK.
(2012)
PEPTIDES COMPRISING THE NOVEL PCNA INTERACTING SEQUENCE APIM, INCREASES THE CYTOTOXICITY OF CHEMOTHERAPEUTIC DRUGS BY IMPAIRING THE CELLS DEFENSE MECHANISMS.
Annals of Oncology
Sammendrag/Abstract
-
Bjørnstad, Linn;
Meza, Trine Johansen;
Otterlei, Marit;
Olafsrud, Solveig Mjelstad;
Meza-Zepeda, Leonardo Andrés;
Falnes, Pål.
(2012)
Human ALKBH4 Interacts with Proteins Associated with Transcription.
PLOS ONE
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Müller, Rebekka;
Liabakk, Nina-Beate;
Otterlei, Marit.
(2012)
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.
PLOS ONE
Vitenskapelig artikkel
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Akbari, Mansour;
Otterlei, Marit.
(2012)
X-ray repair cross complementing protein 1 in base excision repair.
International Journal of Molecular Sciences
Vitenskapelig oversiktsartikkel/review
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Vitenskapelig artikkel
-
Alevizopoulos, K;
Otterlei, Marit.
(2011)
ATX-101, a novel APIM-motif comprising peptide drug potentiates the action of several chemotherapeutic drugs by blocking the interaction between PCNA and key proteins involved in DNA repair and cell cycle control.
Annals of Oncology
Sammendrag/Abstract
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods
Vitenskapelig artikkel
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Sundheim, Ottar;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2011)
XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage.
Environmental and Molecular Mutagenesis
Vitenskapelig artikkel
-
Arum, Carl-Jørgen;
Kodama, Yosuke;
Rolim, Natale Pinheiro Lage;
Widerøe, Marius;
Anderssen, Endre;
Viset, Trond.
(2010)
A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma.
World Journal of Urology
Vitenskapelig artikkel
-
Akbari, Mansour;
Solvang-Garten, Karin;
Hanssen-Bauer, Audun;
Lieske, Nora V.;
Pettersen, Henrik P Sahlin;
Pettersen, Grete Klippenvåg.
(2010)
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Sammendrag/Abstract
-
Akbari, Mansour;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Liabakk, Nina-Beate;
Otterlei, Marit;
Krokan, Hans Einar.
(2009)
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.
DNA Repair
Vitenskapelig artikkel
-
Langevin, C;
Maidou-Peindara, P;
Aas, Per Arne;
Jacquot, G;
Otterlei, Marit;
Slupphaug, Geir.
(2009)
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect.
Journal of Virology
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel/review
-
Akbari, Mansour;
Visnes, Torkild;
Krokan, Hans Einar;
Otterlei, Marit.
(2008)
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
DNA Repair
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
-
Akbari, Mansour;
Otterlei, Marit;
Pena-Diaz, J;
Krokan, Hans Einar.
(2007)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Vitenskapelig artikkel
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Sammendrag/Abstract
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Krokan, Hans Einar.
(2006)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Vitenskapelig artikkel
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Vitenskapelig oversiktsartikkel/review
-
Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy.
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Sammendrag/Abstract
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
-
Pohler, JRG;
Otterlei, Marit;
Warbrick, E.
(2005)
An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit.
BMC Molecular Biology
Vitenskapelig artikkel
-
Luna, Gomez Luisa;
Luna, L;
Rolseth, V;
Hildrestrand, GA;
Otterlei, Marit;
Dantzer, F.
(2005)
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys(326) polymorphic variant.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Opresko, PL;
Otterlei, Marit;
Graakjaer, J;
Bruheim, P;
Dawut, L;
Kolvraa, S.
(2004)
The Werner syndrome helicase and exonuclease cooperate to resolve telometric D-loops in a manner regulated by TRF1 and TRF2.
Molecular Cell
Vitenskapelig artikkel
-
Sharma, S;
Otterlei, Marit;
Sommers, JA;
Driscoll, HC;
Dianov, GL;
Kao, HI.
(2004)
WRN helicase and Flap endonuclease 1 forms a complex upon replication arrest and together process branch-migrating DNA structures associated with the replication fork.
Molecular Biology of the Cell
Vitenskapelig artikkel
-
Fan, JS;
Otterlei, Marit;
Wong, HK;
Tomkinson, AE;
Wilson, DM.
(2004)
XRCC1 co-localizes and physically interacts with PCNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
-
Bayton, Kathy;
Otterlei, Marit;
Bjørås, Magnar;
Kobbe, C von;
Bohr, V.A.;
Seeberg, Erling Christen.
(2003)
WRN interacts physically and functionally with the recombination mediator protein RAD52.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Baynton, Kathy;
Otterlei, Marit;
Bjørås, M.;
Kobbe, Cayetano von;
Bohr, Vilhelm;
Seeberg, E..
(2003)
WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*.
JBC Papers in Press
Vitenskapelig artikkel
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, Hilde;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair of DNA in mammalian cells.
FEBS Letters
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, H.;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair in mammalian cells.
FEBS Letters
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
-
Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal
Vitenskapelig artikkel
-
Bharati, S.;
Krokan, Hans Einar;
Kristiansen, L;
Otterlei, Marit;
Slupphaug, Geir.
(1998)
Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Otterlei, Marit;
Haug, T.;
Nagelhus, T.A;
Slupphaug, Geir;
Lindmo, T.;
Krokan, Hans Einar.
(1998)
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Nilsen, H.;
Otterlei, Marit;
Haug, T.;
Solum, K.;
Nagelhus, T.A;
Skorpen, Frank.
(1997)
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Nagelhus, T.;
Haug, T.;
Singh, K.K.;
Keshav, K.F.;
Skorpen, Frank;
Bharati, S..
(1997)
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A.
Journal of Biological Chemistry
Vitenskapelig artikkel
Bøker
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
Plenum Press
Plenum Press
Fagbok
Del av bok/rapport
-
Krokan, Hans Einar;
Standal, Rune;
Bharati, Sangeeta;
Otterlei, Marit;
Haug, Terje;
Slupphaug, Geir.
(1997)
Uracil in DNA and the family of concerved uracil DNA glycosylases.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
Rapport
-
Bergum, Olaug Elisabeth Torheim;
Otterlei, Marit;
Bruheim, Per.
(2025)
Multi-omics analysis of bacterial stress responses to identify antibiotic mode of action.
NTNU Norges teknisk-naturvitenskapelige universitet
NTNU Norges teknisk-naturvitenskapelige universitet
Doktorgradsavhandling
-
Røst, Lisa Marie;
Otterlei, Marit;
Bruheim, Per.
(2020)
Targeted Mass Spectrometric Metabolite Profiling for Studies of Central Carbon Metabolism.
Norges teknisk-naturvitenskapelige universitet
Norges teknisk-naturvitenskapelige universitet
Doktorgradsavhandling
-
Müller, Rebekka;
Otterlei, Marit.
(2009)
APIM's mechanisms of action.
Norwegian University of Science and Technology, Faculty of Medicine
Norwegian University of Science and Technology, Faculty of Medicine
Mastergradsoppgave
-
Sterten, Heidi;
Krøkje, Åse;
Otterlei, Marit;
Slupphaug, Geir.
(2007)
Ekspresjon, rensing og funksjonelle studier av rekombinant humant replikasjonsprotein A (RPA).
NTNU
NTNU
Mastergradsoppgave
-
Pettersen, Grete Klippenvåg;
Otterlei, Marit.
(2006)
DNA repair complexes.
Privat
Privat
Mastergradsoppgave
-
Jørgensen, Kjersti;
Otterlei, Marit.
(1998)
Human uracil DNA glycosylase. Egenskaper til enzymer med og uten presekvens.
[Mangler utgivernavn]
[Mangler utgivernavn]
Mastergradsoppgave
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Mekanismer for intracellulær sortering av UNG-proteiner studert ved molekylærbiologiske og biofysiske metoder.
[Mangler utgivernavn]
[Mangler utgivernavn]
Rapport
-
Holsve, Marianne;
Otterlei, Marit.
(1998)
Sekvenser i UNG2 som er viktige for UDG-aktivitet, Mg2eion stimulering og intracellulær sortering.
[Mangler utgivernavn]
[Mangler utgivernavn]
Rapport
-
Skjåk-Bræk, Gudmund;
Espevik, Terje;
Otterlei, Marit;
Smidsrød, Olav;
Soon-Shiong, P..
(1995)
Homologous guluronic acid alginate coating composition for in vivo application and implantation and method using the same.
[Mangler utgivernavn]
[Mangler utgivernavn]
Rapport
Undervisning
Emner
Formidling
2023
-
IntervjuHestvik, Ingebjørg; Singleton, Amanda Holstad; Otterlei, Marit. (2023) Ny metode baner vei for nye antibiotika. Gemini.no Gemini.no [null]
2019
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PosterRøst, Lisa Marie; Løkken, Erle Gustavsen; Otterlei, Marit; Bruheim, Per. (2019) Glioblastoma cells respond to hypoxia by increased cell growth and altered TCA-cycle progression. NBS Vintermøte , Røros 2019-01-24 - 2019-01-27
2018
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PosterOlaisen, Camilla; Røst, Lisa Marie; Nedal, Aina; Petrovic, Voin; Kvitvang, Hans Fredrik Nyvold; Bruheim, Per. (2018) Proliferating Cell Nuclear Antigen (PCNA) has a Central Role in Regulation of the Glycolysis in Haematological Cancer Cells. Metabolism and Cancer , Marriott New York Brooklyn Bridge 2018-09-28 - 2018-10-01
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PosterKim, Jana; Søgaard, Caroline Krogh; Kim, Eugene; Bathen, Tone Frost; Otterlei, Marit; Moestue, Siver Andreas. (2018) Diffusion weighted MRI simplifies therapy monitoring in TRAMP mice. Joint Annual Meeting ISMRM-ESMRMB , Paris 2018-06-16 - 2018-06-21
2016
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PosterSøgaard, Caroline Danielsen; Petrovic, Voin; Blindheim, Augun; Gederaas, Odrun Arna; Arum, Carl-Jørgen; Otterlei, Marit. (2016) PCNA-targeting APIM-peptide alters response to DNA damage in human bladder cancer cells on a signaling level. 2nd EMBO Cellular Signalling & Cancer Therapy Conference , Cavtat 2016-05-27 - 2016-05-31
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PosterRøst, Lisa Marie; Olaisen, Camilla; Petrovic, Voin; Otterlei, Marit; Bruheim, Per. (2016) Blocking the Stress-specific APIM-PCNA Interaction in Multiple Myeloma Cells Cause Significant Changes in Central Carbon Metabolism. ISCaM 2016: Metabolic Networks in Cancer , Brussel 2016-10-26 - 2016-10-29
2012
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Vitenskapelig foredragGederaas, Odrun; Bachke, Siri; Sørgaard, Caroline Danielsen; Viset, Trond; Arum, Carl-Jørgen; Otterlei, Marit. (2012) Increased efficacy of intravesical chemotherapy in an orthotopic rat bladder cancer model by targeting PCNA with the novel synthetic peptide drug ATX-101. Congress, USA. Urology (korrekt navn blir supplert) 2012-11-30 - 2012-11-30
-
Vitenskapelig foredragOtterlei, Marit. (2012) APIM-peptides targeting PCNA induce apoptosis in cancer cells. The 3rd Erling Seeberg Symposium on DNA Repair , Trondheim 2012-07-19 - 2012-07-23
-
PosterArum, Carl-Jørgen; Gederaas, Odrun; Bachke, Siri; Viset, Trond; Otterlei, Marit. (2012) Targeting DNA repair mechanisms increases efficiency of intravesical chemotherapy in an orthotopic rat bladder model. info kommer , info kommer 2012-11-30 - 2012-11-30
2011
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PosterBaglo, Yan; Müller, Rebekka; Otterlei, Marit; Gederaas, Odrun Arna. (2011) Analysis of stress responses induced by hexylaminolevulinate-mediated photodynamic treatment. 14th Congress of the European Society for Photobiology , Geneva 2011-09-01 - 2011-09-06
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Vitenskapelig foredragMüller, Rebekka; Giljam, Karin Margaretha; Liabakk, Nina-Beate; Otterlei, Marit. (2011) Efficient repair of UV-induced DNA damage during replication depends on direct XPA-PCNA interaction. Eukaryotic DNA Replication & Genome Maintenance , Cold Spring Harbor 2011-09-06 - 2011-09-10
-
PosterMüller, Rebekka; Jacob, Havjin; Bachke, Siri; Giljam, Karin Margaretha; Otterlei, Marit. (2011) Inhibition of the NF-kappaB pathway by the APIM-peptide. Responses to DNA damage: from molecular mechanism to human disease , Egmond aan Zee 2011-04-03 - 2011-04-08
2010
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
2009
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PosterBruheim, Per; Sletta, Håvard; Klinkenberg, Geir; Ellingsen, Trond Erling; Krokan, Hans Einar; Otterlei, Marit. (2009) Systems biology and high resolution genome-wide phenotyping of yeast used for identification of cellular and molecular effects of DNA damaging agents. 3rd US-EU Workshop "Systems level understanding of DNA damage responses" , Egmond aan Zee 2009-03-30 - 2009-04-01
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Vitenskapelig foredragSlupphaug, Geir; Doseth, Berit; Kavli, Bodil Merete; Visnes, Torkild; Hagen, Lars; Torseth, Kathrin. (2009) Genomic uracil processing in mice and men. 2.nd Erling Seeberg symposium on DNA repair , Ålesund/Geiranger 2009-06-20 - 2009-06-25
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Vitenskapelig foredragOtterlei, Marit. (2009) Identification of a novel and widespread PCNA interacting motif with potential use in chemotherapy. Tirsdagseminar, IBT, NTNU , IBT, NTNU 2009-11-25 -
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Vitenskapelig foredragOtterlei, Marit. (2009) A new PCNA binding motif with possible implication in chemotherapy. Torsdagseminar, IMBV, UiO , UiO 2009-09-03 -
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Vitenskapelig foredragOtterlei, Marit. (2009) APIM Therapeutics, improving chemotherapy for cancer patients. Selbu møte 2009 2009-10-05 - 2009-10-06
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Vitenskapelig foredragKrokan, Hans Einar; Visnes, Torkild; Doseth, Berit; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete. (2009) Uracil in DNA and its processing. 3rd US-EU Conference- Repair of Endogenous Genome Damage , Moody Gardens Hotel, Galveston, Texas 2009-02-21 - 2009-02-25
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Vitenskapelig foredragOtterlei, Marit. (2009) A New PCNA Binding Motif which Sensitizes Cancer Cells to Chemotherapy. Symposium on trends and needs in medical technology and health care 2009-11-05 - 2009-11-06
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. 2nd Erling Seeberg Symposium on DNA Repair 2009-06-20 - 2009-06-25
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PosterPsonka-Antonczyk, Katarzyna Maria; Akbari, Mansour; Otterlei, Marit; Krokan, Hans Einar; Stokke, Bjørn Torger. (2009) Uracil-DNA glycosylase (UNG) interacting with mismatched DNA – a single molecule approach. European Biophysics Congress , Genoa 2009-07-11 - 2009-07-15
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Faglig foredrag
2008
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Vitenskapelig foredragSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance , St. Petersburg 2008-06-24 - 2008-06-26
2007
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Vitenskapelig foredragSæten, Christina; Misund, Kristine; Steigedal, Tonje; Otterlei, Marit; Lægreid, Astrid; Thommesen, Liv. (2007) Complex functional studies in mammalian cells using transfected cell arrays. The Norwegian Bichemical Society 43. Contact Meeting , Lillehammer 2007-02-01 - 2007-02-04
2006
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PosterHanssen-Bauer, Audun; Solvang-Garten, Karin; Akbari, Mansour; Krokan, Hans Einar; Otterlei, Marit. (2006) Functional analysis of XRCC1 associated repair complexes containing the XRCC1 polymorphisms Arg194Trp, Arg280His, and Arg399Gln. DNA repair: from Molecular Mechanism to Human Disease , Noordwijkerhout 2006-04-02 - 2006-04-07
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PosterHagen, Lars; Kavli, Bodil Merete; Sundheim, Ottar; Sousa, Mirta; Otterlei, Marit; Liabakk, Nina-Beate. (2006) Regulation of uracil base excision repair by post-translational modifications. Erling Seeberg Symposium on DNA Repair 2006-05-28 - 2006-06-02
2005
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PosterOtterlei, Marit; Akbari, Mansour; Hanssen-Bauer, Audun; Garten, Karin; III, David Wilson; Andersen, Sonja Benedikte. (2005) Base Excision Repair and Single Strand Break Repair proficient XRCC1 complexes. DNA repair meeting , Sicily 2005-11-28 - 2005-12-03
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PosterBruland, Torunn; Sæten, Christina; Strømmen, Tonje; Bergum, Hallgeir; Otterlei, Marit; Thommesen, Liv. (2005) High-throughput characterisation of gene function using cell microarray. The2nd ESF Functional Genomic Conference, Oslo , Oslo 2005-09-06 - 2005-09-10
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PosterKavli, Bodil Merete; Diaz, Javier Pena; Otterlei, Marit; Liabakk, Nina-Beate; Giljam, Karin Margaretha; Krokan, Hans Einar. (2005) The enzymatic activity of human uracil-DNA glycosylase UNG2 is regulated by N-terminal phosphorylation during cell cycle. 2nd EU-US DNA Repair Meeting: Endogeneous Stress, Base excision repair and related processes , Erice, Sicily 2005-11-28 - 2005-12-03
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PosterDiaz, Javier Pena; Hegre, Siv Anita; Akbari, Mansour; Sousa, Mirta; Sundheim, Ottar; Hanssen-Bauer, Audun. (2005) Recruitment of the chaperone Hsp70 to Base Excision Repair complexes. 2nd EU-US DNA RepairMeeting 2005-11-29 - 2005-12-03
2004
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PosterKavli, Bodil; Otterlei, Marit; Liabakk, Nina-Beate; Krokan, Hans Einar; Slupphaug, Geir. (2004) The mutant UNG2-F-25 1S associated with HIGM syndrome is abnormally translocated and degraded, and results in impaired nuclear uracil excision and accumulation of genomic uracil. ASM Conference on DNA Repair and Mutagenesis , Bermuda 2004-11-14 - 2004-11-20
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PosterAkbari, Mansour; Monterotti, Bruno; Krokan, Hans Einar; Otterlei, Marit. (2004) XRCC1-Associated repair complexes (ARC). DNA-repair and mutagenesis: From molecular structure to biological consequences 2004-11-14 - 2004-11-20
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PosterOtterlei, Marit. (2004) Biochemical and Genetic Characterization og the interaction between Werner Syndrome protein and Fen-1 suggests their mechanism of action in vivo. DNA Repair and mutagenesis: From molecular structure to biological consequences 2004-11-14 - 2004-11-20
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Vitenskapelig foredragBruland, Torunn; Bergum, Hallgeir; Steigedal, Tonje; Otterlei, Marit; Thommesen, Liv; Lægreid, Astrid. (2004) Array based screening og gene function and cell-biological application of transfected-cell microarrays. NBS Kontaktmøte , Hafjell 2004-01-15 - 2004-01-18
2003
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Vitenskapelig foredragOtterlei, Marit; Bruheim, Per; Byungchan, Ahn; Baynton, Kathy; Opresko, Patricia; Seeberg, E.. (2003) DNA damage causing replication arrest leads to a relocation of WRN hekicase to complexes containing proteins from the RAD52 epistasis group: RAD52, RAD51, RAD54 and RAD54B. Possible role for WRN in regulation of HR. International Workshop on Werner Syndrome , Lansdowne 2003-05-31 -
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Faglig foredragOtterlei, Marit. (2003) Involvement of WRN in homologous recombination. , Trondheim, Norge 2003-09-30 -
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PosterLuna, Luisa; Rolseth, Veslemøy; Otterlei, Marit; Hildestrand, Gunn; Seeberg, Erling Christen. (2003) Subnuclear localisation of hOgg1 in dependent on phosphorylation of serine 36 and is disrupted in the polymorphic hOgg1-Cys326 allele. Vintermøte , Geilo 2003-01-23 - 2003-01-26
2002
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IntervjuSundan, Anders; Otterlei, Marit; Krokan, Hans Einar. (2002) Det gode liv på Øya: Rapport fra et vinnermiljø. [null] 2002-06-13
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PosterKavli, Bodil; Otterlei, Marit; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Krokan, Hans Einar. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in uracil-DNA repair in the nucleus. Mutagenesis and Carcinogenesis, Gordon Research Conference , Ventura, California, USA 2002-03-08 -
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PosterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Aas, Per Arne. (2002) Substrate preference and enzyme kinetics reveal distinct properties of UNG2 and SMUG1 in cellular base-excision repair; hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup. 32nd Annual Meeting of European Environmental Mutagen Society. DNA Damage and Repair Fundamental Aspects and Contribution to Human Disorders , Warsaw. Poland 2002-09-07 -
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PosterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Otterlei, Marit; Skorpen, Frank. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in DNA-uracil repair in the nucleus. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life , Quality Hotel Røros 2002-01-20 -
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Vitenskapelig foredragAas, Per Arne; Otterlei, Marit; Skorpen, Frank; Akbari, Mansour; Slupphaug, Geir; Krokan, Hans Einar. (2002) Repair of alkylated single-stranded DNA and RNA in living cells. 38.Biokjemiske kontaktmøte Functional genomics-the mosaics of life , Røros 2002-01-20 -
2001
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Faglig foredragOtterlei, Marit. (2001) Interaction between replication and repair proteins. , Medisinsk Teknisk Senter 2001-12-11 -
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PosterSundheim, Ottar; Otterlei, Marit; Kavli, Bodil; Skorpen, Frank; Aas, Per Arne; Krokan, Hans Einar. (2001) Structure-function analysis of the human uracil-DNA glycosylase hSMUG1. Sixth International School on the Crystallography of Biological Macromolecules. , Como, Italy 2001-05-17 -
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Faglig foredragOtterlei, Marit. (2001) DNA skader og reparasjon. , Inst. for bioteknologi, Fakultet for kjemi, NTNU 2001-10-02 -
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Faglig foredragOtterlei, Marit. (2001) "....om gfp, yfp, cfp, kofokal og FRET...". Oppdalsmøte 2001 , Oppdal, 21.- 22. mars 2001
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PosterSlupphaug, Geir; Skorpen, Frank; Nilsen, H.; Fenstad, M.; Rosello, Ch.; Otterlei, Marit. (2001) Functional implications of the UNG2 regulatory domain in BER and transcription regulation. Workshop DNA repair: Interplay with other cellular processes , Noordwijkerhout, The Netherlands, February 25 - March 2, 2001
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Vitenskapelig foredragLuna, L.; Morland, I.; Rolseth, V.; Bjørås, M.; Otterlei, Marit; Seeberg, E.. (2001) Cell cycle dependent expression and intracellular sorting characteristics of the human Ogg1 DNA glycosylase and its mutant form S236C. Workshop on DNA repair: interplay with other cellular processes. , Noordwijkerhout, Nederland 2001-03-25 -
2000
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Faglig foredragKrokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja. (2000) Structure-function aspects of human uracil-DNA glycosylase and its interactions with other proteins. DNA Base Excision Repair Workshop (BER 2000 WORKSHOP) , Galveston, Texas, March 10 - 13, 2000
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Faglig foredragNilsen, Hilde; Roswell, Ian; Robins, Peter; Slupphaug, Geir; Steinsbekk, Kristin; Otterlei, Marit. (2000) Characterisation Of The Major Murine Uracil-DNA Glycosylase And Expression Patterns And Generation of ung/-Knockout Mice. DNA Base Excision Repair Workshop (BER 2000 Workshop) , Galveston, Texas, USA March 10 - 13, 2000
1999
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PosterKrokan, Hans Einar; Slupphaug, Geir; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank. (1999) Excicion Repar of DNA Damage 1. , 1-7 november 1999
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PosterOtterlei, Marit; Kavli, B.; Standal, R.; Skjelbred, Camilla; Bharati, S.; Krokan, Hans Einar. (1999) In vivo Repair of AP-sites in the E.coli Chromosome. , 1-7 november 1999
1998
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Faglig foredragOtterlei, Marit. (1998) Signals for nuclear and mitochondrial targeting of human uracil-DNA-glycosylases and co-localisation of the nuclear form with replication protein A. Norsk Biokjemisk Selskaps møte , Lillehammer
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Vitenskapelig foredragBharati, Sangeeta; Krokan, Hans Einar; Kristiansen, Lena; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1)is processed to two forms one of which is resistant to inhibition by AP-sites. AACR Special Conference in Cancer Research. Endogeneous sources of Mutations. , Ft. Myers, Florida
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Faglig foredragOtterlei, Marit. (1998) Studies on intracellular sorting of proteins fused to Enhanced Green Fluorescent Protein (EGFP). Storlienmøøte , Storlien
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PosterKavli, Bodil; Otterlei, Marit; Skjelbred, Camilla; Standal, Rune; Bharati, Sangeeta; Krokan, Hans Einar. (1998) Mutation frequency and mutation spectra caused by chromosomal AP-site in repair deficient E.coli strains. Norsk Biokjemisk Selskaps møte , Lillehammer