Marie Klevjer
Om
Jeg er forsker i forskningsgruppa Cardiogenomics ved Institutt for sirkulasjon og bildediagnostikk (ISB), NTNU. Forskningen min undersøker hvordan genetiske variasjoner, fysisk aktivitet og livsstilsfaktorer påvirker risiko for hjerte- og karsykdom. Jeg er spesielt interessert i hvordan disse sammenhengene kan variere mellom kvinner og menn, og hvordan genetisk informasjon kan brukes til mer presis forebygging og behandling.
Forskning
Min forskning forsøker å forbedre risikoprediksjonen for hjerte- og karsykdom ved å utforske genetiske faktorer. Hovedfokuset er på treningsrelaterte risikofaktorer, hovedsakelig maksimalt oksygenopptak og hvilepuls. Prosjektet benytter seg av de nyeste metodene innen genetikk.
Publikasjoner
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study
In contrast with the current observational knowledge of RHR and AF, an inverse causal association between RHR and AF was demonstrated in both linear and non-linear MR for RHR values up to 90 bpm.
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study
We identified 38 novel SNP associated with V̇O 2peak in HUNT. Two SNP were nominally replicated in UKB. Several interesting genes emerged from the functional analyses, among them one previously reported to be associated with CVD and another with CRF.
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease
Our findings provide insight into the pleiotropic effects of the RHR variants, contributing towards an improved understanding of mechanisms linking RHR and disease.
2026
-
Øvretveit, Karsten;
Klevjer, Marie;
Brumpton, Ben Michael;
Wisløff, Ulrik;
Hveem, Kristian;
Bye, Anja.
(2026)
Polygenic prediction of cardiorespiratory fitness in the Trøndelag health study (HUNT).
Scientific Reports
Vitenskapelig artikkel
2025
-
Joensuu, Laura;
Lukander, Volter;
Herranen, Päivi;
Tynkkynen, Niko Paavo;
Kujala, Urho;
López-Bueno, Rubén.
(2025)
Genetic Contribution of Cardiorespiratory Fitness in Morbidity and Mortality: A Prospective FinnGen and HUNT study.
medRxiv
Vitenskapelig artikkel
-
Øvretveit, Karsten;
Klevjer, Marie;
Brumpton, Ben Michael;
Wisløff, Ulrik;
Hveem, Kristian;
Bye, Anja.
(2025)
Polygenic prediction of cardiorespiratory fitness: The HUNT Study.
medRxiv
Vitenskapelig artikkel
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Consortium, FinnGen.
(2025)
Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts.
British Journal of Sports Medicine
Vitenskapelig artikkel
2024
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Klevjer, Marie.
(2024)
Genetic liability to sedentary behavior increases the risk of cardiovascular disease incidence: Evidence from the FinnGen cohort with 293,250 individuals.
medRxiv
Vitenskapelig artikkel
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Øvretveit, Karsten;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2024)
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.
European Journal of Preventive Cardiology (EJPC)
Vitenskapelig artikkel
2023
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory
fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Vitenskapelig oversiktsartikkel/review
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Wisløff, Ulrik;
Langaas, Mette;
Bye, Anja.
(2023)
Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study.
Physiological Genomics
Vitenskapelig artikkel
-
Klevjer, Marie;
Rasheed, Humaira;
Romundstad, Pål Richard;
Madssen, Erik;
Brumpton, Ben Michael;
Bye, Anja.
(2023)
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study.
Europace
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Vitenskapelig oversiktsartikkel/review
-
Sperstad, Sigri Bakken;
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Røsbjørgen, Ragnhild.
(2023)
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study.
PLOS ONE
Vitenskapelig artikkel
-
Tynkkynen, Niko Paavo;
Törmäkangas, Timo;
Palviainen, Teemu;
Hyvärinen, Matti;
Klevjer, Marie;
Joensuu, Laura.
(2023)
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study.
European Journal of Epidemiology (EJE)
Vitenskapelig artikkel
2022
-
Benegiamo, Giorgia;
Sleiman, Maroun Bou;
Wohlwend, Martin;
Rodríguez-López, Sandra;
Goeminne, Ludger J. E.;
Laurila, Pirkka-Pekka.
(2022)
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Nature Metabolism
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Hansen, Ailin Falkmo;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2022)
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study.
Medicine & Science in Sports & Exercise
Vitenskapelig artikkel
-
Nodeland, Markus;
Klevjer, Marie;
Sæther, Julie Caroline;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Wisløff, Ulrik.
(2022)
Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study.
Atherosclerosis
Vitenskapelig artikkel
-
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Gigante, Bruna;
Gjære, Sigrid.
(2022)
Small LDL subfractions are associated with coronary atherosclerosis despite nodifferences in conventional lipids.
Physiological Genomics
Vitenskapelig artikkel
2020
-
Bye, Anja;
Klevjer, Marie;
Ryeng, Einar;
Silva, Gustavo Jose Justo;
Moreira, Jose Bianco Nascimento;
Stensvold, Dorthe.
(2020)
Identification of novel genetic variants associated with cardiorespiratory fitness.
Progress in cardiovascular diseases
Vitenskapelig oversiktsartikkel/review
2019
-
Soysa, Ann Kristin Hjelle De;
Klevjer, Marie;
Grill, Valdemar Erik Robert;
Mostad, Ingrid Løvold.
(2019)
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3.
Metabolism: Clinical and Experimental
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Øvretveit, Karsten;
Klevjer, Marie;
Brumpton, Ben Michael;
Wisløff, Ulrik;
Hveem, Kristian;
Bye, Anja.
(2026)
Polygenic prediction of cardiorespiratory fitness in the Trøndelag health study (HUNT).
Scientific Reports
Vitenskapelig artikkel
-
Joensuu, Laura;
Lukander, Volter;
Herranen, Päivi;
Tynkkynen, Niko Paavo;
Kujala, Urho;
López-Bueno, Rubén.
(2025)
Genetic Contribution of Cardiorespiratory Fitness in Morbidity and Mortality: A Prospective FinnGen and HUNT study.
medRxiv
Vitenskapelig artikkel
-
Øvretveit, Karsten;
Klevjer, Marie;
Brumpton, Ben Michael;
Wisløff, Ulrik;
Hveem, Kristian;
Bye, Anja.
(2025)
Polygenic prediction of cardiorespiratory fitness: The HUNT Study.
medRxiv
Vitenskapelig artikkel
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Consortium, FinnGen.
(2025)
Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts.
British Journal of Sports Medicine
Vitenskapelig artikkel
-
Joensuu, Laura;
Koivunen, Kaisa;
Tynkkynen, Niko Paavo;
Palviainen, Teemu;
Kaprio, Jaakko;
Klevjer, Marie.
(2024)
Genetic liability to sedentary behavior increases the risk of cardiovascular disease incidence: Evidence from the FinnGen cohort with 293,250 individuals.
medRxiv
Vitenskapelig artikkel
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Øvretveit, Karsten;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2024)
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.
European Journal of Preventive Cardiology (EJPC)
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory
fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Vitenskapelig oversiktsartikkel/review
-
Nordeidet, Ada Nilsen;
Klevjer, Marie;
Wisløff, Ulrik;
Langaas, Mette;
Bye, Anja.
(2023)
Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study.
Physiological Genomics
Vitenskapelig artikkel
-
Klevjer, Marie;
Rasheed, Humaira;
Romundstad, Pål Richard;
Madssen, Erik;
Brumpton, Ben Michael;
Bye, Anja.
(2023)
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study.
Europace
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Bye, Anja.
(2023)
The genetic basis of exercise and cardiorespiratory fitness – relation to cardiovascular disease.
Current Opinion in Physiology
Vitenskapelig oversiktsartikkel/review
-
Sperstad, Sigri Bakken;
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Røsbjørgen, Ragnhild.
(2023)
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study.
PLOS ONE
Vitenskapelig artikkel
-
Tynkkynen, Niko Paavo;
Törmäkangas, Timo;
Palviainen, Teemu;
Hyvärinen, Matti;
Klevjer, Marie;
Joensuu, Laura.
(2023)
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study.
European Journal of Epidemiology (EJE)
Vitenskapelig artikkel
-
Benegiamo, Giorgia;
Sleiman, Maroun Bou;
Wohlwend, Martin;
Rodríguez-López, Sandra;
Goeminne, Ludger J. E.;
Laurila, Pirkka-Pekka.
(2022)
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Nature Metabolism
Vitenskapelig artikkel
-
Klevjer, Marie;
Nordeidet, Ada Nilsen;
Hansen, Ailin Falkmo;
Madssen, Erik;
Wisløff, Ulrik;
Brumpton, Ben Michael.
(2022)
Genome-Wide Association Study Identifies New Genetic Determinants of Cardiorespiratory Fitness: The Trøndelag Health Study.
Medicine & Science in Sports & Exercise
Vitenskapelig artikkel
-
Nodeland, Markus;
Klevjer, Marie;
Sæther, Julie Caroline;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Wisløff, Ulrik.
(2022)
Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study.
Atherosclerosis
Vitenskapelig artikkel
-
Sæther, Julie Caroline;
Klevjer, Marie;
Giskeødegård, Guro F.;
Bathen, Tone Frost;
Gigante, Bruna;
Gjære, Sigrid.
(2022)
Small LDL subfractions are associated with coronary atherosclerosis despite nodifferences in conventional lipids.
Physiological Genomics
Vitenskapelig artikkel
-
Bye, Anja;
Klevjer, Marie;
Ryeng, Einar;
Silva, Gustavo Jose Justo;
Moreira, Jose Bianco Nascimento;
Stensvold, Dorthe.
(2020)
Identification of novel genetic variants associated with cardiorespiratory fitness.
Progress in cardiovascular diseases
Vitenskapelig oversiktsartikkel/review
-
Soysa, Ann Kristin Hjelle De;
Klevjer, Marie;
Grill, Valdemar Erik Robert;
Mostad, Ingrid Løvold.
(2019)
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3.
Metabolism: Clinical and Experimental
Vitenskapelig artikkel
Formidling
2024
-
PosterKlevjer, Marie; Øvretveit, Karsten; Brumpton, Ben Michael; Wisløff, Ulrik; Hveem, Kristian; Bye, Anja. (2024) Polygenic prediction of cardiorespiratory fitness: The HUNT Study. Nordic Conference on Future Health , Trondheim 2024-09-09 - 2024-09-12
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ProgramdeltagelseKlevjer, Marie. (2024) Populærvitenskapelig innslag om hvilepuls i programmet "God ettermiddag Trøndelag" på NRK P1 Trøndelag. NRK P1 Trøndelag NRK P1 Trøndelag [null] 2024-10-22
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IntervjuKlevjer, Marie. (2024) "Et sprekere liv". Nyhetsbrev Sprek abonnementer Nyhetsbrev Sprek abonnementer [null] 2024-10-28
2023
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PosterSæther, Julie Caroline; Follestad, Turid; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Bruna. (2023) Circulating lipoprotein subfractions and microRNAs as potential biomarkers for improved risk prediction of myocardial infarction: the HUNT study. 3rd Nordic Metabolomics Conference , Trondheim 2023-10-18 - 2023-10-20
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PosterNordeidet, Ada Nilsen; Bye, Anja; Klevjer, Marie; Brumpton, Ben Michael; Wisløff, Ulrik; Madssen, Erik. (2023) Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease. A HEALTHY FUTURE , Trondheim 2023-10-05 -
2022
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PosterKlevjer, Marie; Nordeidet, Ada Nilsen; Bye, Anja. (2022) Genome-wide association study indentify new genetic determinants of resting heart rate. Nordic Society of Human Genetics and Precision Medicine 2022-11-03 - 2022-11-04
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Vitenskapelig foredragKlevjer, Marie; Nordeidet, Ada Nilsen; Hansen, Ailin Falkmo; Madssen, Erik; Wisløff, Ulrik; Brumpton, Ben Michael. (2022) New genetic determinants of VO2max-level identified by GWAS: The HUNT Study. Frontiers in Cardiovascular Biomedicine 2022-04-29 - 2022-05-01
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Vitenskapelig foredragKlevjer, Marie; Nordeidet, Ada Nilsen; Hansen, Ailin Falkmo; Madssen, Erik; Wisløff, Ulrik; Brumpton, Ben Michael. (2022) Genome-wide association study identify new genetic determinants of cardiorespiratory fitness: The HUNT Study. ESC Preventive Cardiology 2022 2022-04-07 - 2022-04-09
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PosterSæther, Julie Caroline; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Brune; Gjære, Sigrid. (2022) Small LDL-5 subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids. EAS Congress 2022 , Milano 2022-05-22 - 2022-05-25
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PosterNordeidet, Ada Nilsen; Bye, Anja; Klevjer, Marie; Langaas, Mette. (2022) Cardiovascular disease-wide association study to investigate shared genetics with peak oxygen uptake. ESC Congress 2022 , Barcelona 2022-08-26 - 2022-08-29
2020
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PosterKlevjer, Marie; Sæther, Julie Caroline; Vesterbekkmo, Elisabeth Kleivhaug; Giskeødegård, Guro F.; Bathen, Tone Frost; Gigante, Bruna. (2020) LDL-5 are elevated in patients with coronary atherosclerosis, despite no increase in total levels of LDL-cholesterol. ESC Congress 2020 - The digital experience 2020-08-29 - 2020-09-01
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Vitenskapelig foredragKlevjer, Marie; Brumpton, Ben Michael; Madssen, Erik; Bye, Anja. (2020) Identifying new genetic markers for maximal oxygen uptake. EPINOR Online Conference 2020-11-09 - 2020-11-09
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ProgramdeltagelseKlevjer, Marie. (2020) Vi har lenge mistenkt at kondis går i arv. Nå er det bevist.». NRK P2 - Studio 2 NRK P2 - Studio 2 [null] 2020-03-04
2019
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Vitenskapelig foredragBye, Anja; Klevjer, Marie; Ryeng, Einar; Silva, Gustavo Justo da; Moreira, Jose Bianco Nascimento; Stensvold, Dorthe. (2019) Identification of genetic variants associated with the cardiovascular disease risk factor, low aerobic fitness - The HUNT study. European Society of Cardiology Congress 2019 , Paris 2019-08-30 - 2019-09-05