Kristin Roseth Aass
Om
My research is focused on Multiple Myeloma, a hematologic cancer of terminally differentiated plasma cells in the bone marrow. Myeloma is an heterogenous and incurable disease, and the ultimate aim is, through translational research, identify new treatment targets, develop efficient individualized therapy strategies for patients. Currently I work on understanding how the immune cell compartment influence disease outcome and treatment response in myeloma patients, where the goal is to identify predictive immunoprofiles or immune markers that can aid in patient stratification and treatment decisions in the future, as well as identifying novel immune-associated treatment targets.
About me:
I studied Biotechnology at Department of Biotechnology and Food Science, NTNU, for three years before I completed my MSc in Molecular Medicine at Department of Clinical and Molecular Medicine, NTNU. I finished my PhD in 2020 at Therese Standal´s group (https://www.ntnu.edu/employees/therese.standal) and have continued with a Norwegian Cancer Society funded post doc on the same group, where I follow up the research findings from my PhD. Through these years I have studied the molecular role of the cytokine IL-32, a biomarker for poor prognosis-myeloma patients and role of miRNA as predictors of prognosis in myeloma, using methods ranging from in vivo mouse experiments, cell culture, CRISPR/Cas9, metabolic and survival assays and flow cytometry to advanced imaging and next generation sequencing. The last years I have turned my focus to high-throughput methods, in particular single cell sequencing, to study immunological aspects of myeloma. Recently, I was granted a researcher position from Liaison Committee between the Central Norway Regional Health Authority (RHA) and NTNU and in 2024 I was awarded a Researcher Project grant from the Norwegian Cancer Society for the project "Single cell multi-omics to explore how epigenetic and functional states of immune cells shape treatment response to anti-CD38 monoclonal antibodies in multiple myeloma" where we will characterize the immune environment in myeloma patients receiving anti-CD38 based therapy. The major aim of the study is to identify epigenetic and functional features of the immune system that can predict response to anti-CD38 or act as potential drug targets. I will recruit a PhD candidate in this project in 2026.
I am part of the Clinical Academic Group for Multiple Myeloma in Central-Norway, Center for Myeloma Research in Trondheim, and Centre of Molecular Inflammation Research (CEMIR).
Supervision:
2017-2018
M.Sc supervision
2018-2019 Alex Waters, Fulbrigth fellowship
2019. Tonje Marie Vikene Nedal
Luca van den Brink
2019-2020 Synne Stokke Tryggestad
PhD co-supervision
2020- 2023 Martin H. Kastnes
2020- 2024 Synne Stokke Tryggestad
Forskerlinje supervision
2022- Siri Anshushaug Bouma
Kompetanseord
Publikasjoner
2025
-
Emma, Busarello,;
Giulia, Biancon,;
Ilaria, Cimignolo,;
Vittorio, Bontempi,;
Giorgia, Bucciarelli,;
Marianna, Ciuffreda,;
Zuhairia, Ibnat,;
Fabio, Lauria,;
Paolo, Macchi,;
Maria, Marino, Stefano.
(2025)
Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease | Nature Communications.
Nature Communications
Vitenskapelig artikkel
-
Mjelle, Robin;
Castro, Ícaro;
Aass, Kristin Roseth.
(2025)
The viral landscape in metastatic solid cancers.
Heliyon
Vitenskapelig artikkel
2024
-
Nedal, Tonje Marie Vikene;
Moen, Siv Helen;
Roseth, Ingrid Aass;
Tryggestad, Synne Stokke;
Aass, Kristin Roseth;
Hov, Gunhild Garmo;
Hella, Hanne;
Sponaas, Anne Marit;
Standal, Therese.
(2024)
Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma.
Scientific Reports
Vitenskapelig artikkel
-
Tryggestad, Synne Stokke;
Roseth, Ingrid Aass;
Aass, Kristin Roseth;
Ørning, Nadia Elise Helene;
Mjelle, Robin;
Hella, Hanne;
Standal, Therese.
(2024)
Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen.
Frontiers in Immunology
Vitenskapelig artikkel
2023
-
Kastnes, Martin Haugrud;
Aass, Kristin Roseth;
Bouma, Siri Anshushaug;
Årseth, Charlotte;
Zahoor, Muhammad;
Yurchenko, Mariya;
Standal, Therese.
(2023)
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes.
Frontiers in Oncology
Vitenskapelig artikkel
-
Aass, Kristin Roseth;
Tryggestad, Synne Stokke;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Nedal, Tonje Marie Vikene;
Misund, Kristine;
Standal, Therese.
(2023)
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells.
Frontiers in Immunology
Vitenskapelig artikkel
2022
-
Aass, Kristin Roseth;
Nedal, Tonje Marie Vikene;
Tryggestad, Synne Stokke;
Haukås, Einar;
Slørdahl, Tobias Schmidt;
Waage, Anders;
Standal, Therese;
Mjelle, Robin.
(2022)
Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma.
Scientific Reports
Vitenskapelig artikkel
-
Aass, Kristin Roseth;
Nedal, Tonje Marie Vikene;
Bouma, Siri Anshushaug;
Tryggestad, Synne Stokke;
Haukås, Einar;
Slørdahl, Tobias Schmidt;
Waage, Anders;
Standal, Therese;
Mjelle, Robin.
(2022)
Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival.
British Journal of Cancer
Vitenskapelig artikkel
2021
-
Aass, Kristin Roseth;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Tryggestad, Synne Stokke;
van den Brink, Luca Mare;
Roseth, Ingrid Aass;
Westhrin, Marita;
Zahoor, Muhammad;
Moen, Siv Helen;
Nedal, Tonje Marie Vikene.
(2021)
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells.
iScience
Vitenskapelig artikkel
2020
-
Aass, Kristin Roseth;
Kastnes, Martin;
Standal, Therese.
(2020)
Molecular interactions and functions of IL-32.
Journal of Leukocyte Biology
Vitenskapelig artikkel
-
Mjelle, Robin;
Aass, Kristin Roseth;
Sjursen, Wenche;
Hofsli, Eva;
Sætrom, Pål.
(2020)
sMETASeq: combined profiling of microbiota and host small RNAs.
iScience
Vitenskapelig artikkel
-
Standal, Therese;
Aass, Kristin Roseth.
(2020)
The role IL-32 in multiple myeloma.
NTNU Open
Doktoravhandling
2017
-
Zahoor, Muhammad;
Westhrin, Marita;
Aass, Kristin Roseth;
Moen, Siv Helen;
Misund, Kristine;
Psonka-Antonczyk, Katarzyna Maria;
Giliberto, Mariaserena;
Buene, Glenn;
Sundan, Anders;
Waage, Anders.
(2017)
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss.
Blood Advances
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Emma, Busarello,;
Giulia, Biancon,;
Ilaria, Cimignolo,;
Vittorio, Bontempi,;
Giorgia, Bucciarelli,;
Marianna, Ciuffreda,;
Zuhairia, Ibnat,;
Fabio, Lauria,;
Paolo, Macchi,;
Maria, Marino, Stefano.
(2025)
Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease | Nature Communications.
Nature Communications
Vitenskapelig artikkel
-
Aass, Kristin Roseth;
Nedal, Tonje Marie Vikene;
Tryggestad, Synne Stokke;
Haukås, Einar;
Slørdahl, Tobias Schmidt;
Waage, Anders;
Standal, Therese;
Mjelle, Robin.
(2022)
Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma.
Scientific Reports
Vitenskapelig artikkel
-
Kastnes, Martin Haugrud;
Aass, Kristin Roseth;
Bouma, Siri Anshushaug;
Årseth, Charlotte;
Zahoor, Muhammad;
Yurchenko, Mariya;
Standal, Therese.
(2023)
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes.
Frontiers in Oncology
Vitenskapelig artikkel
-
Nedal, Tonje Marie Vikene;
Moen, Siv Helen;
Roseth, Ingrid Aass;
Tryggestad, Synne Stokke;
Aass, Kristin Roseth;
Hov, Gunhild Garmo;
Hella, Hanne;
Sponaas, Anne Marit;
Standal, Therese.
(2024)
Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma.
Scientific Reports
Vitenskapelig artikkel
-
Aass, Kristin Roseth;
Kastnes, Martin;
Standal, Therese.
(2020)
Molecular interactions and functions of IL-32.
Journal of Leukocyte Biology
Vitenskapelig artikkel
-
Tryggestad, Synne Stokke;
Roseth, Ingrid Aass;
Aass, Kristin Roseth;
Ørning, Nadia Elise Helene;
Mjelle, Robin;
Hella, Hanne;
Standal, Therese.
(2024)
Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen.
Frontiers in Immunology
Vitenskapelig artikkel
-
Aass, Kristin Roseth;
Tryggestad, Synne Stokke;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Nedal, Tonje Marie Vikene;
Misund, Kristine;
Standal, Therese.
(2023)
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells.
Frontiers in Immunology
Vitenskapelig artikkel
-
Zahoor, Muhammad;
Westhrin, Marita;
Aass, Kristin Roseth;
Moen, Siv Helen;
Misund, Kristine;
Psonka-Antonczyk, Katarzyna Maria;
Giliberto, Mariaserena;
Buene, Glenn;
Sundan, Anders;
Waage, Anders.
(2017)
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss.
Blood Advances
Vitenskapelig artikkel
-
Aass, Kristin Roseth;
Mjelle, Robin;
Kastnes, Martin Haugrud;
Tryggestad, Synne Stokke;
van den Brink, Luca Mare;
Roseth, Ingrid Aass;
Westhrin, Marita;
Zahoor, Muhammad;
Moen, Siv Helen;
Nedal, Tonje Marie Vikene.
(2021)
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells.
iScience
Vitenskapelig artikkel
-
Mjelle, Robin;
Aass, Kristin Roseth;
Sjursen, Wenche;
Hofsli, Eva;
Sætrom, Pål.
(2020)
sMETASeq: combined profiling of microbiota and host small RNAs.
iScience
Vitenskapelig artikkel
-
Mjelle, Robin;
Castro, Ícaro;
Aass, Kristin Roseth.
(2025)
The viral landscape in metastatic solid cancers.
Heliyon
Vitenskapelig artikkel
-
Aass, Kristin Roseth;
Nedal, Tonje Marie Vikene;
Bouma, Siri Anshushaug;
Tryggestad, Synne Stokke;
Haukås, Einar;
Slørdahl, Tobias Schmidt;
Waage, Anders;
Standal, Therese;
Mjelle, Robin.
(2022)
Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival.
British Journal of Cancer
Vitenskapelig artikkel
Studentoppgave eller avhandling
-
Standal, Therese;
Aass, Kristin Roseth.
(2020)
The role IL-32 in multiple myeloma.
NTNU Open
Doktoravhandling
Undervisning
Emner
Formidling
2024
-
KonferanseforedragRoseth, Ingrid Aass; Behsen, Alenka Djarmila; Moen, Siv Helen; Sponaas, Anne Marit; Aass, Kristin Roseth; Tryggestad, Synne Stokke; Hella, Hanne; Størdal, Berit Fladvad; Nedal, Tonje Marie Vikene; Standal, Therese. (2024) Mass cytometry of murine immune cell populations upon diet induced obesity and early stages of myeloma. Norwegian Flow Cytometry Meeting 2024
2023
-
ForedragAass, Kristin Roseth. (2023) Karakterisering av immunceller i beinmargen hos myelomatosepasienter på enkeltcellenivå- hvilke endringer skjer fra diagnose til tilbakefall etter behandling?. Seminar for myelomatosepasienter
-
KonferanseforedragAass, Kristin Roseth. (2023) Characterization of the bone marrow immune microenvironment in myeloma patients with short and long time to progression by scRNA-sequencing. 4th Norwegian Myeloma Workshop
2022
-
KonferanseforedragTryggestad, Synne Stokke; Aass, Kristin Roseth; Buene, Glenn; Standal, Therese. (2022) Infections may render myeloma cells less sensitive to common myeloma drugs. 3rd Norwegian myeloma workshop
2021
-
KonferanseposterKastnes, Martin Haugrud; Standal, Therese; Aass, Kristin Roseth; Sponaas, Anne-Marit; Tryggestad, Synne Stokke. (2021) Investigating the role of IL-32 in T cells. British Society for Immunology Congress 2021
2019
-
KonferanseposterAass, Kristin Roseth; Mjelle, Robin; Westhrin, Marita; Zahoor, Muhammad; Yurchenko, Mariya; Buene, Glenn; Slørdahl, Tobias Schmidt; Hella, Hanne; Waage, Anders; Standal, Therese. (2019) IL-32 is a novel growth factor and metabolic regulator in multiple myeloma cells. The Second Conference on Molecular Mechanisms of Inflammation in Trondheim June 3-6, 2019.
-
KonferanseposterAass, Kristin Roseth; Mjelle, Robin; Zahoor, Muhammad; Yurchenko, Mariya; Westhrin, Marita; Buene, Glenn; Hella, Hanne; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese. (2019) IL-32 is a novel growth factor and metabolic regulator for multiple myeloma cells. Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment.