Katja Scheffler
Om
Leader of the Neurobiological Laboratory with a strong expertise in the field of aging, neurodegenerative disease, DNA repair, epigenetics, and translational medicine.
My research lab is situated at both the Department of Neurology, St. Olavs Hospital and INB, NTNU which allows conducting high-quality basic research as well as patient-oriented clinical studies.
Forskning
Neuroepigenetics - Base Modifications in Cognitive Function
Genomic DNA is continuously challenged by endogenous and exogenous oxidative agents, thus preserving genomic integrity is a key for development and health. Base excision repair (BER) is the major pathway for removal of oxidized bases in the genome. BER is initiated by DNA glycosylases, recognizing and excising a broad range of base lesions. However, processing of oxidized base lesions to avoid DNA mutations seems not the main activity of DNA glycosylases but they rather have a novel role in regulating the epigenetic landscape. The main focus of my research is to unravel the molecular mechanism and function of DNA glycosylases in epigenetic remodeling in brain, thus laying the basis for novel diagnostic- and therapeutic strategies for brain-related disorders.
Next-Generation Translational Medicine in Alzheimer's disease
AD is a complex age-related neurodegenerative disorder that affect millions of people worldwide. With the steady growth of life expectancy, AD has become one of the biggest health challenges of our society. The underlying mechanisms that contribute to the development and progression of AD are still not fully understood, and no treatment is available to halt or delay the disease. We aim to adress these challenges by etablishing a platform for patient-derived cell models to reveal novel molecular pathways leading to AD.
Publikasjoner
2022
-
Egiazarian, Milena Armenovna;
Strømstad, Silje;
Sakshaug, Teri;
Núñez Nescolarde, Ana Beatriz;
Bethge, Nicole;
Bjørås, Magnar;
Scheffler, Katja.
(2022)
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease.
Free Radical Biology & Medicine.
volum 193 (Pt 2).
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Bråthen, Geir;
White, Linda Rosemary;
Salvesen, Øyvind;
Aarsland, Dag;
Hessen, Erik;
Fladby, Tormod;
Waterloo, Knut K;
Scheffler, Katja.
(2022)
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden.
JAMA Network Open.
volum 5 (11).
Vitenskapelig artikkel
-
Tari, Atefe R;
Berg, Helene Haugen;
Videm, Vibeke;
Bråthen, Geir;
White, Linda Rosemary;
Røsbjørgen, Ragnhild;
Scheffler, Katja;
Dalen, Håvard;
Holte, Espen;
Håberg, Asta Kristine;
Selbæk, Geir;
Lydersen, Stian;
Duezel, Emrah;
Bergh, Sverre;
Logan-halvorsrud, Kjell Rune;
Sando, Sigrid Botne;
Wisløff, Ulrik.
(2022)
Safety and efficacy of plasma transfusion from exercise - trained donors in patients with early Alzheimer’s disease: protocol for the ExPlas study.
BMJ Open.
Faglig artikkel
2021
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria;
Fernandez Berrocal, Marion Silvana;
SIkko, Sunniva Bøe;
Vetlesen, Susanne;
Kusnierczyk, Anna;
Olsen, Ann-Karin Hardie;
Gutzkow, Kristine Bjerve;
Rowe, Alexander D.;
Wang, Wei;
Moldestad, Olve;
Syrstad, Monica Dahl;
Slupphaug, Geir;
Eide, Lars;
Klungland, Arne.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology.
volum 4.
Vitenskapelig artikkel
-
Quiles-Jiménez, Ana M T;
Gregersen, Ida;
Segers, Filip;
Skarpengland, Tonje;
Kroustallaki, Pinelopi;
Yang, Kuan;
Kong, Xiang Yi;
Lauritzen, Knut Husø;
Olsen, Maria Belland;
Karlsen, Tom Rune;
Nyman, Tuula Anneli;
Sagen, Ellen Lund;
Bjerkeli, Vigdis;
Suganthan, Rajikala;
Nygård, Ståle;
Scheffler, Katja;
Prins, Jurriën;
Van der Veer, Eric;
Øgaard, Jonas.
(2021)
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.
Atherosclerosis.
volum 324.
Vitenskapelig artikkel
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja;
Bjørås, Magnar.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences.
volum 22:12924 (23).
Vitenskapelig oversiktsartikkel/review
2020
-
Farooq, Amna;
Grønmyr, Sindre;
Omer, Ali Avan;
Rognes, Torbjørn;
Scheffler, Katja;
Bjørås, Magnar;
Wang, Junbai.
(2020)
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data.
Computational and Structural Biotechnology Journal.
volum 18.
Vitenskapelig artikkel
-
Scheffler, Katja;
Jalland, Clara Maria Osnes;
Benestad, Sylvie L.;
Moldal, Torfinn;
Ersdal, Cecilie;
Gunnes, Gjermund;
Suganthan, Rajikala;
Bjørås, Magnar;
Tranulis, Michael A..
(2020)
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
Free Radical Biology & Medicine.
volum 152.
Vitenskapelig artikkel
2019
-
Scheffler, Katja;
Bjørås, Karine Øian;
Bjørås, Magnar.
(2019)
Diverse functions of DNA glycosylases processing oxidative base lesions in brain.
DNA Repair.
volum 81.
Vitenskapelig oversiktsartikkel/review
-
Ystgaard, Martin Bogale;
Scheffler, Katja;
Suganthan, Rajikala;
Bjørås, Magnar;
Ranheim, Trine;
Sagen, Ellen Lund;
Halvorsen, Bente;
Saugstad, Ola Didrik;
Yndestad, Arne.
(2019)
Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy.
Neonatology.
volum 115 (4).
Vitenskapelig artikkel
2018
-
Scheffler, Katja;
Rachek, Lyudmila;
You, Panpan;
Rowe, Alexander D.;
Wang, Wei;
Kuśnierczyk, Anna;
Kittelsen, Lene Svendsen;
Bjørås, Magnar;
Eide, Lars.
(2018)
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis.
DNA Repair.
volum 61.
Vitenskapelig artikkel
2017
-
Olsen, Maria Belland;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Vinge, Leif Erik;
Alfsnes, Katrine;
Palibrk, Vuk;
Wang, Junbai;
Neurauter, Christine Gran;
Gomez, Luisa Fernanda Luna;
Johansen, Jostein;
Øgaard, Jonas;
Ohm, Ingrid Kristine;
Slupphaug, Geir;
Kusnierczyk, Anna;
Fiane, Arnt E;
Brorson, Sverre Henning;
Zhang, Lili;
Gullestad, Lars;
Louch, William Edward.
(2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell reports.
volum 18.
Vitenskapelig artikkel
-
Rolseth, Veslemøy;
Gomez, Luisa Fernanda Luna;
Olsen, Ann-Karin;
Suganthan, Rajikala;
Scheffler, Katja;
Neurauter, Christine Gran;
Esbensen, Qin Ying;
Kusnierczyk, Anna;
Hildrestrand, Gunn Annette;
Graupner, Anne;
Andersen, Jill Mari;
Slupphaug, Geir;
Klungland, Arne;
Nilsen, Hilde;
Bjørås, Magnar.
(2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.
Scientific Reports.
volum 7.
Vitenskapelig artikkel
2016
-
Jalland, Clara Maria Osnes;
Scheffler, Katja;
Benestad, Sylvie Lafond;
Moldal, Torfinn;
Ersdal, Cecilie;
Gunnes, Gjermund;
Suganthan, Rajikala;
Bjørås, Magnar;
Tranulis, Michael A..
(2016)
Neil3 induced neurogenesis protects against prion disease during the clinical phase.
Scientific Reports.
volum 6.
Vitenskapelig artikkel
-
Palibrk, Vuk;
Suganthan, Rajikala;
Scheffler, Katja;
Wang, Wei;
Bjørås, Magnar;
Bøe, Stig Ove.
(2016)
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic–ischemic encephalopathy model.
Cell Death & Disease.
volum 7.
Vitenskapelig artikkel
-
Skarpengland, Tonje;
Dahl, Tuva Børresdatter;
Skjelland, Mona;
Scheffler, Katja;
Sousa, Mirta;
Gregersen, Ida;
Kusnierczyk, Anna;
Sharma, Animesh;
Slupphaug, Geir;
Eide, Lars;
Segers, Filip;
Skagen, Karolina Ryeng;
Dahl, Christen Peder;
Russell, David;
Folkersen, Lasse;
Krohg-Sørensen, Kirsten;
Holm, Sverre;
Bjørås, Magnar;
Aukrust, Pål.
(2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.
Free Radical Biology & Medicine.
volum 97.
Vitenskapelig artikkel
-
Skarpengland, Tonje;
Holm, Sverre;
Scheffler, Katja;
Gregersen, Ida;
Dahl, Tuva Børresdatter;
Suganthan, Rajikala;
Segers, Filip;
Østlie, Ingunn;
Otten, Jeroen J.T.;
Gomez, Luisa Fernanda Luna;
Ketelhuth, Daniel F.J.;
Lundberg, Anna M.;
Neurauter, Christine Gran;
Hildrestrand, Gunn Annette;
Skjelland, Mona;
Bjørndal, Bodil;
Svardal, Asbjørn M.;
Iversen, Per Ole;
Hedin, Ulf.
(2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Scientific Reports.
volum 6:28337.
Vitenskapelig artikkel
-
Wang, Wei;
Scheffler, Katja;
Esbensen, Qin Ying;
Eide, Lars.
(2016)
Quantification of DNA Damage by Real-Time qPCR.
Mitochondrial DNA Methods and Protocols.
Faglig kapittel
2015
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna;
Rowe, Alexander D.;
Vågbø, Cathrine Broberg;
Vetlesen, Susanne;
Eide, Lars;
Slupphaug, Geir;
Yusaku, Nakabeppu;
Timothy, Bredy;
Klungland, Arne;
Bjørås, Magnar.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports.
volum 13 (12).
Vitenskapelig artikkel
-
Wang, Wei;
Esbensen, Qin Ying;
Scheffler, Katja;
Eide, Lars.
(2015)
Analysis of Mitochondrial DNA and RNA Integrity by a Real-Time qPCR-Based Method.
Mitochondrial Medicine.
Faglig kapittel
2014
-
Jalland, Clara;
Benestad, Sylvie Lafond;
Ersdal, Cecilie;
Scheffler, Katja;
Suganthan, Rajikala;
Nakabeppu, Yusaku;
Eide, Lars;
Bjørås, Magnar;
Tranulis, Michael A..
(2014)
Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage.
Free Radical Biology & Medicine.
volum 68.
Vitenskapelig artikkel
-
Strand, Janne Maren;
Scheffler, Katja;
Bjørås, Magnar;
Eide, Lars.
(2014)
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences.
DNA Repair.
volum 18 (1).
Vitenskapelig artikkel
-
Strand, Janne Maren;
Skinnes, Ragnhild;
Scheffler, Katja;
Rootwelt, Terje;
Woldseth, Berit;
Bjørås, Magnar;
Eide, Lars.
(2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis.
Metabolism: Clinical and Experimental.
volum 63 (8).
Vitenskapelig artikkel
-
Wang, Wei;
Scheffler, Katja;
Esbensen, Qin Ying;
Strand, Janne Maren;
Stewart, James B.;
Bjørås, Magnar;
Eide, Lars.
(2014)
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.
PLOS ONE.
volum 9 (5).
Vitenskapelig artikkel
2012
-
Halsne, Ruth;
Esbensen, Qin Ying;
Wang, Wei;
Scheffler, Katja;
Suganthan, Rajikala;
Bjørås, Magnar;
Eide, Lars.
(2012)
Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis.
DNA Repair.
volum 11 (3).
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Egiazarian, Milena Armenovna;
Strømstad, Silje;
Sakshaug, Teri;
Núñez Nescolarde, Ana Beatriz;
Bethge, Nicole;
Bjørås, Magnar;
Scheffler, Katja.
(2022)
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease.
Free Radical Biology & Medicine.
volum 193 (Pt 2).
Vitenskapelig artikkel
-
Grøntvedt, Gøril Rolfseng;
Sando, Sigrid Botne;
Lauridsen, Camilla;
Bråthen, Geir;
White, Linda Rosemary;
Salvesen, Øyvind;
Aarsland, Dag;
Hessen, Erik;
Fladby, Tormod;
Waterloo, Knut K;
Scheffler, Katja.
(2022)
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden.
JAMA Network Open.
volum 5 (11).
Vitenskapelig artikkel
-
Tari, Atefe R;
Berg, Helene Haugen;
Videm, Vibeke;
Bråthen, Geir;
White, Linda Rosemary;
Røsbjørgen, Ragnhild;
Scheffler, Katja;
Dalen, Håvard;
Holte, Espen;
Håberg, Asta Kristine;
Selbæk, Geir;
Lydersen, Stian;
Duezel, Emrah;
Bergh, Sverre;
Logan-halvorsrud, Kjell Rune;
Sando, Sigrid Botne;
Wisløff, Ulrik.
(2022)
Safety and efficacy of plasma transfusion from exercise - trained donors in patients with early Alzheimer’s disease: protocol for the ExPlas study.
BMJ Open.
Faglig artikkel
-
Hildrestrand, Gunn Annette;
Rolseth, Veslemøy;
Kunath, Nicolas;
Suganthan, Rajikala;
Jensen, Vidar;
Bugaj, Anna Maria;
Fernandez Berrocal, Marion Silvana;
SIkko, Sunniva Bøe;
Vetlesen, Susanne;
Kusnierczyk, Anna;
Olsen, Ann-Karin Hardie;
Gutzkow, Kristine Bjerve;
Rowe, Alexander D.;
Wang, Wei;
Moldestad, Olve;
Syrstad, Monica Dahl;
Slupphaug, Geir;
Eide, Lars;
Klungland, Arne.
(2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Communications Biology.
volum 4.
Vitenskapelig artikkel
-
Quiles-Jiménez, Ana M T;
Gregersen, Ida;
Segers, Filip;
Skarpengland, Tonje;
Kroustallaki, Pinelopi;
Yang, Kuan;
Kong, Xiang Yi;
Lauritzen, Knut Husø;
Olsen, Maria Belland;
Karlsen, Tom Rune;
Nyman, Tuula Anneli;
Sagen, Ellen Lund;
Bjerkeli, Vigdis;
Suganthan, Rajikala;
Nygård, Ståle;
Scheffler, Katja;
Prins, Jurriën;
Van der Veer, Eric;
Øgaard, Jonas.
(2021)
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.
Atherosclerosis.
volum 324.
Vitenskapelig artikkel
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja;
Bjørås, Magnar.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences.
volum 22:12924 (23).
Vitenskapelig oversiktsartikkel/review
-
Farooq, Amna;
Grønmyr, Sindre;
Omer, Ali Avan;
Rognes, Torbjørn;
Scheffler, Katja;
Bjørås, Magnar;
Wang, Junbai.
(2020)
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data.
Computational and Structural Biotechnology Journal.
volum 18.
Vitenskapelig artikkel
-
Scheffler, Katja;
Jalland, Clara Maria Osnes;
Benestad, Sylvie L.;
Moldal, Torfinn;
Ersdal, Cecilie;
Gunnes, Gjermund;
Suganthan, Rajikala;
Bjørås, Magnar;
Tranulis, Michael A..
(2020)
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
Free Radical Biology & Medicine.
volum 152.
Vitenskapelig artikkel
-
Scheffler, Katja;
Bjørås, Karine Øian;
Bjørås, Magnar.
(2019)
Diverse functions of DNA glycosylases processing oxidative base lesions in brain.
DNA Repair.
volum 81.
Vitenskapelig oversiktsartikkel/review
-
Ystgaard, Martin Bogale;
Scheffler, Katja;
Suganthan, Rajikala;
Bjørås, Magnar;
Ranheim, Trine;
Sagen, Ellen Lund;
Halvorsen, Bente;
Saugstad, Ola Didrik;
Yndestad, Arne.
(2019)
Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy.
Neonatology.
volum 115 (4).
Vitenskapelig artikkel
-
Scheffler, Katja;
Rachek, Lyudmila;
You, Panpan;
Rowe, Alexander D.;
Wang, Wei;
Kuśnierczyk, Anna;
Kittelsen, Lene Svendsen;
Bjørås, Magnar;
Eide, Lars.
(2018)
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis.
DNA Repair.
volum 61.
Vitenskapelig artikkel
-
Olsen, Maria Belland;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Vinge, Leif Erik;
Alfsnes, Katrine;
Palibrk, Vuk;
Wang, Junbai;
Neurauter, Christine Gran;
Gomez, Luisa Fernanda Luna;
Johansen, Jostein;
Øgaard, Jonas;
Ohm, Ingrid Kristine;
Slupphaug, Geir;
Kusnierczyk, Anna;
Fiane, Arnt E;
Brorson, Sverre Henning;
Zhang, Lili;
Gullestad, Lars;
Louch, William Edward.
(2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell reports.
volum 18.
Vitenskapelig artikkel
-
Rolseth, Veslemøy;
Gomez, Luisa Fernanda Luna;
Olsen, Ann-Karin;
Suganthan, Rajikala;
Scheffler, Katja;
Neurauter, Christine Gran;
Esbensen, Qin Ying;
Kusnierczyk, Anna;
Hildrestrand, Gunn Annette;
Graupner, Anne;
Andersen, Jill Mari;
Slupphaug, Geir;
Klungland, Arne;
Nilsen, Hilde;
Bjørås, Magnar.
(2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.
Scientific Reports.
volum 7.
Vitenskapelig artikkel
-
Jalland, Clara Maria Osnes;
Scheffler, Katja;
Benestad, Sylvie Lafond;
Moldal, Torfinn;
Ersdal, Cecilie;
Gunnes, Gjermund;
Suganthan, Rajikala;
Bjørås, Magnar;
Tranulis, Michael A..
(2016)
Neil3 induced neurogenesis protects against prion disease during the clinical phase.
Scientific Reports.
volum 6.
Vitenskapelig artikkel
-
Palibrk, Vuk;
Suganthan, Rajikala;
Scheffler, Katja;
Wang, Wei;
Bjørås, Magnar;
Bøe, Stig Ove.
(2016)
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic–ischemic encephalopathy model.
Cell Death & Disease.
volum 7.
Vitenskapelig artikkel
-
Skarpengland, Tonje;
Dahl, Tuva Børresdatter;
Skjelland, Mona;
Scheffler, Katja;
Sousa, Mirta;
Gregersen, Ida;
Kusnierczyk, Anna;
Sharma, Animesh;
Slupphaug, Geir;
Eide, Lars;
Segers, Filip;
Skagen, Karolina Ryeng;
Dahl, Christen Peder;
Russell, David;
Folkersen, Lasse;
Krohg-Sørensen, Kirsten;
Holm, Sverre;
Bjørås, Magnar;
Aukrust, Pål.
(2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.
Free Radical Biology & Medicine.
volum 97.
Vitenskapelig artikkel
-
Skarpengland, Tonje;
Holm, Sverre;
Scheffler, Katja;
Gregersen, Ida;
Dahl, Tuva Børresdatter;
Suganthan, Rajikala;
Segers, Filip;
Østlie, Ingunn;
Otten, Jeroen J.T.;
Gomez, Luisa Fernanda Luna;
Ketelhuth, Daniel F.J.;
Lundberg, Anna M.;
Neurauter, Christine Gran;
Hildrestrand, Gunn Annette;
Skjelland, Mona;
Bjørndal, Bodil;
Svardal, Asbjørn M.;
Iversen, Per Ole;
Hedin, Ulf.
(2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Scientific Reports.
volum 6:28337.
Vitenskapelig artikkel
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna;
Rowe, Alexander D.;
Vågbø, Cathrine Broberg;
Vetlesen, Susanne;
Eide, Lars;
Slupphaug, Geir;
Yusaku, Nakabeppu;
Timothy, Bredy;
Klungland, Arne;
Bjørås, Magnar.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports.
volum 13 (12).
Vitenskapelig artikkel
-
Jalland, Clara;
Benestad, Sylvie Lafond;
Ersdal, Cecilie;
Scheffler, Katja;
Suganthan, Rajikala;
Nakabeppu, Yusaku;
Eide, Lars;
Bjørås, Magnar;
Tranulis, Michael A..
(2014)
Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage.
Free Radical Biology & Medicine.
volum 68.
Vitenskapelig artikkel
-
Strand, Janne Maren;
Scheffler, Katja;
Bjørås, Magnar;
Eide, Lars.
(2014)
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences.
DNA Repair.
volum 18 (1).
Vitenskapelig artikkel
-
Strand, Janne Maren;
Skinnes, Ragnhild;
Scheffler, Katja;
Rootwelt, Terje;
Woldseth, Berit;
Bjørås, Magnar;
Eide, Lars.
(2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis.
Metabolism: Clinical and Experimental.
volum 63 (8).
Vitenskapelig artikkel
-
Wang, Wei;
Scheffler, Katja;
Esbensen, Qin Ying;
Strand, Janne Maren;
Stewart, James B.;
Bjørås, Magnar;
Eide, Lars.
(2014)
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.
PLOS ONE.
volum 9 (5).
Vitenskapelig artikkel
-
Halsne, Ruth;
Esbensen, Qin Ying;
Wang, Wei;
Scheffler, Katja;
Suganthan, Rajikala;
Bjørås, Magnar;
Eide, Lars.
(2012)
Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis.
DNA Repair.
volum 11 (3).
Vitenskapelig artikkel
Del av bok/rapport
-
Wang, Wei;
Scheffler, Katja;
Esbensen, Qin Ying;
Eide, Lars.
(2016)
Quantification of DNA Damage by Real-Time qPCR.
Mitochondrial DNA Methods and Protocols.
Faglig kapittel
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Wang, Wei;
Esbensen, Qin Ying;
Scheffler, Katja;
Eide, Lars.
(2015)
Analysis of Mitochondrial DNA and RNA Integrity by a Real-Time qPCR-Based Method.
Mitochondrial Medicine.
Faglig kapittel