Brooke N. Wolford
Forskning
ProtectHearts
ProtectHearts will use the world’s largest population-biobank-linked proteomics datasets to develop a novel protein-based risk score (ProtRS) for cardiovascular disease.
HUNT AI for Heart Health
Combining structured and unstructured health data with genomics, we will employ explainable artificial intelligence (XAI) methods to improve CVD prediction.
INTERVENE
We integrate AI and human genetics to develop tools for disease prevention, diagnosis, and personalised treatment.
Publikasjoner
A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk
Polygenic scores (PGSs) represent the genetic risk for complex diseases. We develop a novel framework to estimate country-, age-, and sex-specific estimates of cumulative incidence stratified by PGS for 18 diseases.
Discovery and systematic characterization of risk variants for coronary artery disease in over a million participants.
We conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci.
Formidling
International research study finds new genetic links to heart disease
An international research study published in Nature Genetics in December 2022 revealed new information about the role genetics play in heart disease.
We're Doomed, We're Saved Podcast
In We’re doomed we’re saved, Andreas Horchler and Louise von Stechow speak to two Polygenic Risk Score researchers, who contributed to the international and interdisciplinary, EU-funded INTERVENE project.
2024
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Poster(2024) Differential gene expression and regulation at single nuclei resolution in muscle of statin users. AtheroNet 3rd Working Group Meeting , Valencia, Spain 2024-02-28 - 2024-03-01
2023
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Vitenskapelig foredrag(2023) Differential gene expression and regulation at single nuclei resolution in muscle of statin users. American Society of Human Genetics Annual Meeting 2023 , Washington, D.C. 2023-11-01 - 2023-11-05
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Vitenskapelig foredrag(2023) Big data integration: Variability of lifetime risk of complex diseases across polygenic score strata in over 1 million individuals. 3rd meeting of the AtheroNET (Network for implementing multiomics approaches in atherosclerotic cardiovascular disease prevention and research) EU COST Action , Vlorë, Albania 2023-09-29 - 2023-09-29
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Poster(2023) Polygenic risk scores predict blood pressure traits across the lifespan. American Society of Human Genetics 2023 Annual Meeting 2023-11-03 -
2022
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Vitenskapelig foredrag(2022) Variability in lifetime risk of complex diseases across European countries & polygenic score strata in >1 million individuals. American Society of Human Genetics 2022 , Los Angeles, CA, USA 2022-10-25 - 2022-10-29
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Vitenskapelig foredrag(2022) Effect of sex and age on disease prediction with polygenic scores in INTERVENE. European Society of Human Genetics Conference , Vienna, Austria 2022-06-11 - 2022-06-14
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Poster(2022) Polygenic predictions and interactions in hypertension. K.G. Jebsen for Genetic Epidemiology Symposium 2022-11-29 - 2022-11-30
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Vitenskapelig foredrag(2022) Polygenic predictions and interactions in hypertension. Exercise in Medicine , Trondheim 2022-12-14 - 2022-12-15