Wannan Tang
Om
Wannan Tang a neuroscientist with background in clinical medicine. Her research profiles are in a broad neuroscience research range, such as in cellular and molecular neurobiology, two-photon imaging, electrophysiology and rAAV-mediated gene therapy development. She has completed her Master and PhD degrees at the Department of Molecular Neurobiology in Max Plank Institute for Medical Research Heidelberg, Germany, with the late Prof. Peter Seeburg and Dr. Rolf Sprengel as supervisors. Her PhD focused on cellular and molecular technologies to study neural circuits, including gene-manipulated mouse lines and virus mediated gene transfer in neurons. After her PhD, she started her research on glial cells, particularly on brain astrocytes. During year 2012-2020, she has designed and applied various molecular sensors and tools via rAAV gene transfer methods to study brain astrocytes in physiological and disease conditions using two-photon imaging in acute brain slices and in awake behaving animals. In 2017, she received Young Research Talents grant from Research Council of Norway and established her own research group. Since 2021 she has joined Norwegian University of Science and Technology (NTNU), and her research interests were extended to roles of brain astrocytes in neurodegenerative diseases and aging. She is currently focusing on astrocytic functions in brain aging, neurodegeneration and metabolism using combination of various molecular tools, two-photon in vivo imaging and transcriptome studies. In addition, to expend her research competence in translational medicine, with her long-term expertise in rAAV engineering, she carries out projects on developing rAAV-mediated gene therapy treatments for various rare genetic disorders.
Publikasjoner
2026
-
Escobar Doncel, Beatriz;
Zhang, Xiaoyi;
Ljøstad, Åsne;
Fernández de la Puebla, Mario;
Shreyas, Rao;
Fjeldstad, Synnøve Algrøy;
Dahle, Maja Tvedt;
Amiry-Moghaddam, Mahmood Reza;
Bjørås, Magnar;
Fang-Stavem, Fei.
(2026)
Two-photon in vivo imaging reveals cell type-specific mitophagy dynamic changes in mouse somatosensory cortex during aging.
npj Aging
Vitenskapelig artikkel
2025
-
Fernández de la Puebla, Mario;
Zhang, Xiaoyi;
Nagelhus, Erlend Arnulf;
Bjørås, Magnar;
Tang, Wannan.
(2025)
IP3R2-Mediated Astrocytic Ca2+Transients Are Critical to Sustain Modulatory Effects of Locomotion on Neurons in Mouse Somatosensory Cortex.
Cells
Vitenskapelig artikkel
2024
-
Kirchhoff, Frank;
Tang, Wannan.
(2024)
Analysis of Functional NMDA Receptors in Astrocytes.
Methods in molecular biology
Vitenskapelig artikkel
2023
-
Bordoni, Luca;
Thorén, Anna Elisabeth;
Gutiérrez-Jiménez, Eugenio;
Åbjørsbråten, Knut Sindre;
Bjørnstad, Daniel Marelius;
Tang, Wannan;
Stern, Mette;
Østergaard, Leif;
Nagelhus, Erlend Arnulf;
Frische, Sebastian.
(2023)
Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema.
Glia
Vitenskapelig artikkel
-
Hjukse, Jarand Berg;
Fernández de la Puebla, Mario;
Vindedal, Gry Fluge;
Sprengel, Rolf;
Jensen, Vidar;
Nagelhus, Erlend Arnulf;
Tang, Wannan.
(2023)
Increased membrane Ca<sup>2+</sup> permeability drives astrocytic Ca<sup>2+</sup> dynamics during neuronal stimulation at excitatory synapses.
Glia
Vitenskapelig artikkel
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi;
Lång, Anna Ulrika;
Kristiansen, Elise;
Pannone, Marco;
Kissova, Miroslava.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Vitenskapelig artikkel
2022
-
Åbjørsbråten, Knut Sindre;
Skaaraas, Gry Helen Enger Syverstad;
Cunen, Celine Marie Løken;
Bjørnstad, Daniel Marelius;
Binder, Kristin Maria Gullestad;
Bojarskaite, Laura;
Jensen, Vidar;
Nilsson, Lars;
Shreyas, Rao;
Tang, Wannan.
(2022)
Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice.
eLIFE
Vitenskapelig artikkel
2020
-
Bojarskaite, Laura;
Bjørnstad, Daniel Marelius;
Pettersen, Klas Henning;
Cunen, Celine;
Hermansen, Gudmund Horn;
Åbjørsbråten, Knut Sindre;
Chambers, Anna;
Sprengel, Rolf;
Vervaeke, Koen Gerard Alois;
Tang, Wannan.
(2020)
Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep.
Nature Communications
Vitenskapelig artikkel
-
Tang, Wannan;
Zillmann, Uwe;
Sprengel, Rolf.
(2020)
Alternative anesthesia of neonatal mice for global rAAV delivery in the brain with non-detectable behavioral interference in adults.
Frontiers in Behavioral Neuroscience
Vitenskapelig artikkel
2019
-
Rosic, Brana;
Dukefoss, Didrik Bakke;
Åbjørsbråten, Knut Sindre;
Tang, Wannan;
Jensen, Vidar;
Ottersen, Ole Petter;
Enger, Rune;
Nagelhus, Erlend Arnulf.
(2019)
Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression.
Glia
Vitenskapelig artikkel
-
Eilert-Olsen, Martine;
Hjukse, Jarand Berg;
Thoren, Anna;
Tang, Wannan;
Enger, Rune;
Jensen, Vidar;
Pettersen, Klas Henning;
Nagelhus, Erlend Arnulf.
(2019)
Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions.
Glia
Vitenskapelig artikkel
2018
-
Heuser, Kjell;
Nome, Cecilie;
Pettersen, Klas;
Åbjørsbråten, Knut Sindre;
Jensen, Vidar;
Tang, Wannan;
Sprengel, Rolf;
Taubøll, Erik;
Nagelhus, Erlend Arnulf;
Enger, Rune.
(2018)
Ca2+ signals in astrocytes facilitate spread of epileptiform activity.
Cerebral Cortex
Vitenskapelig artikkel
2017
-
Tan, Linette Liqi;
Pelzer, Patric;
Heinl, Céline;
Tang, Wannan;
Gangadharan, Vijayan;
Flor, Herta;
Sprengel, Rolf;
Kuner, Thomas;
Kuner, Rohini.
(2017)
A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity.
Nature Neuroscience
Vitenskapelig artikkel
2016
-
Enger, Rune;
Dukefoss, Didrik Bakke;
Tang, Wannan;
Pettersen, Klas;
Bjørnstad, Daniel Marelius;
Helm, Paul Johannes;
Jensen, Vidar;
Sprengel, Rolf;
Vervaeke, Koen Gerard Alois;
Ottersen, Ole Petter.
(2016)
Deletion of aquaporin-4 curtails extracellular glutamate elevation in cortical spreading depression in awake mice.
Cerebral Cortex
Vitenskapelig artikkel
-
Obenhaus, Horst-Andreas Gustav Wilhelm;
Rozov, Andrei;
Bertocchi, Ilaria;
Tang, Wannan;
Kirsch, Joachim;
Betz, Heinrich;
Sprengel, Rolf.
(2016)
Causal interrogation of neuronal networks and behavior through virally transduced ivermectin receptors.
Frontiers in Molecular Neuroscience
Vitenskapelig artikkel
2015
-
Szokol, Karolina;
Heuser, Kjell;
Tang, Wannan;
Jensen, Vidar;
Enger, Rune;
Bedner, Peter;
Steinhäuser, Christian;
Taubøll, Erik;
Ottersen, Ole Petter;
Nagelhus, Erlend Arnulf.
(2015)
Augmentation of Ca<sup>2+</sup> signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
Frontiers in Cellular Neuroscience
Vitenskapelig artikkel
-
Enger, Rune;
Tang, Wannan;
Vindedal, Gry Fluge;
Jensen, Vidar;
Helm, Paul Johannes;
Sprengel, Rolf;
Looger, Loren L.;
Nagelhus, Erlend Arnulf.
(2015)
Dynamics of ionic shifts in cortical spreading depression.
Cerebral Cortex
Vitenskapelig artikkel
-
Tang, Wannan;
Szokol, Karolina;
Jensen, Vidar;
Enger, Rune;
Trivedi, Chintan A.;
Hvalby, Øyvind Christian dødsbo;
Helm, Paul Johannes;
Looger, Loren L.;
Sprengel, Rolf;
Nagelhus, Erlend Arnulf.
(2015)
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
Journal of Neuroscience
Vitenskapelig artikkel
2014
-
Engin, Elif;
Bakhurin, Konstantin I.;
Smith, Kiersten S,;
Hines, Rochelle M.;
Reynolds, Lauren M.;
Tang, Wannan;
Sprengel, Rolf;
Moss, Stephen J.;
Rudolph, Uwe.
(2014)
Neural basis of benzodiazepine reward: Requirement for α2 containing GABA a receptors in the nucleus accumbens.
Neuropsychopharmacology
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Escobar Doncel, Beatriz;
Zhang, Xiaoyi;
Ljøstad, Åsne;
Fernández de la Puebla, Mario;
Shreyas, Rao;
Fjeldstad, Synnøve Algrøy;
Dahle, Maja Tvedt;
Amiry-Moghaddam, Mahmood Reza;
Bjørås, Magnar;
Fang-Stavem, Fei.
(2026)
Two-photon in vivo imaging reveals cell type-specific mitophagy dynamic changes in mouse somatosensory cortex during aging.
npj Aging
Vitenskapelig artikkel
-
Fernández de la Puebla, Mario;
Zhang, Xiaoyi;
Nagelhus, Erlend Arnulf;
Bjørås, Magnar;
Tang, Wannan.
(2025)
IP3R2-Mediated Astrocytic Ca2+Transients Are Critical to Sustain Modulatory Effects of Locomotion on Neurons in Mouse Somatosensory Cortex.
Cells
Vitenskapelig artikkel
-
Åbjørsbråten, Knut Sindre;
Skaaraas, Gry Helen Enger Syverstad;
Cunen, Celine Marie Løken;
Bjørnstad, Daniel Marelius;
Binder, Kristin Maria Gullestad;
Bojarskaite, Laura;
Jensen, Vidar;
Nilsson, Lars;
Shreyas, Rao;
Tang, Wannan.
(2022)
Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice.
eLIFE
Vitenskapelig artikkel
-
Rosic, Brana;
Dukefoss, Didrik Bakke;
Åbjørsbråten, Knut Sindre;
Tang, Wannan;
Jensen, Vidar;
Ottersen, Ole Petter;
Enger, Rune;
Nagelhus, Erlend Arnulf.
(2019)
Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression.
Glia
Vitenskapelig artikkel
-
Bojarskaite, Laura;
Bjørnstad, Daniel Marelius;
Pettersen, Klas Henning;
Cunen, Celine;
Hermansen, Gudmund Horn;
Åbjørsbråten, Knut Sindre;
Chambers, Anna;
Sprengel, Rolf;
Vervaeke, Koen Gerard Alois;
Tang, Wannan.
(2020)
Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep.
Nature Communications
Vitenskapelig artikkel
-
Tan, Linette Liqi;
Pelzer, Patric;
Heinl, Céline;
Tang, Wannan;
Gangadharan, Vijayan;
Flor, Herta;
Sprengel, Rolf;
Kuner, Thomas;
Kuner, Rohini.
(2017)
A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity.
Nature Neuroscience
Vitenskapelig artikkel
-
Szokol, Karolina;
Heuser, Kjell;
Tang, Wannan;
Jensen, Vidar;
Enger, Rune;
Bedner, Peter;
Steinhäuser, Christian;
Taubøll, Erik;
Ottersen, Ole Petter;
Nagelhus, Erlend Arnulf.
(2015)
Augmentation of Ca<sup>2+</sup> signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
Frontiers in Cellular Neuroscience
Vitenskapelig artikkel
-
Bordoni, Luca;
Thorén, Anna Elisabeth;
Gutiérrez-Jiménez, Eugenio;
Åbjørsbråten, Knut Sindre;
Bjørnstad, Daniel Marelius;
Tang, Wannan;
Stern, Mette;
Østergaard, Leif;
Nagelhus, Erlend Arnulf;
Frische, Sebastian.
(2023)
Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema.
Glia
Vitenskapelig artikkel
-
Enger, Rune;
Tang, Wannan;
Vindedal, Gry Fluge;
Jensen, Vidar;
Helm, Paul Johannes;
Sprengel, Rolf;
Looger, Loren L.;
Nagelhus, Erlend Arnulf.
(2015)
Dynamics of ionic shifts in cortical spreading depression.
Cerebral Cortex
Vitenskapelig artikkel
-
Kirchhoff, Frank;
Tang, Wannan.
(2024)
Analysis of Functional NMDA Receptors in Astrocytes.
Methods in molecular biology
Vitenskapelig artikkel
-
Tang, Wannan;
Szokol, Karolina;
Jensen, Vidar;
Enger, Rune;
Trivedi, Chintan A.;
Hvalby, Øyvind Christian dødsbo;
Helm, Paul Johannes;
Looger, Loren L.;
Sprengel, Rolf;
Nagelhus, Erlend Arnulf.
(2015)
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
Journal of Neuroscience
Vitenskapelig artikkel
-
Tang, Wannan;
Zillmann, Uwe;
Sprengel, Rolf.
(2020)
Alternative anesthesia of neonatal mice for global rAAV delivery in the brain with non-detectable behavioral interference in adults.
Frontiers in Behavioral Neuroscience
Vitenskapelig artikkel
-
Hjukse, Jarand Berg;
Fernández de la Puebla, Mario;
Vindedal, Gry Fluge;
Sprengel, Rolf;
Jensen, Vidar;
Nagelhus, Erlend Arnulf;
Tang, Wannan.
(2023)
Increased membrane Ca<sup>2+</sup> permeability drives astrocytic Ca<sup>2+</sup> dynamics during neuronal stimulation at excitatory synapses.
Glia
Vitenskapelig artikkel
-
Enger, Rune;
Dukefoss, Didrik Bakke;
Tang, Wannan;
Pettersen, Klas;
Bjørnstad, Daniel Marelius;
Helm, Paul Johannes;
Jensen, Vidar;
Sprengel, Rolf;
Vervaeke, Koen Gerard Alois;
Ottersen, Ole Petter.
(2016)
Deletion of aquaporin-4 curtails extracellular glutamate elevation in cortical spreading depression in awake mice.
Cerebral Cortex
Vitenskapelig artikkel
-
Heuser, Kjell;
Nome, Cecilie;
Pettersen, Klas;
Åbjørsbråten, Knut Sindre;
Jensen, Vidar;
Tang, Wannan;
Sprengel, Rolf;
Taubøll, Erik;
Nagelhus, Erlend Arnulf;
Enger, Rune.
(2018)
Ca2+ signals in astrocytes facilitate spread of epileptiform activity.
Cerebral Cortex
Vitenskapelig artikkel
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi;
Lång, Anna Ulrika;
Kristiansen, Elise;
Pannone, Marco;
Kissova, Miroslava.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Vitenskapelig artikkel
-
Obenhaus, Horst-Andreas Gustav Wilhelm;
Rozov, Andrei;
Bertocchi, Ilaria;
Tang, Wannan;
Kirsch, Joachim;
Betz, Heinrich;
Sprengel, Rolf.
(2016)
Causal interrogation of neuronal networks and behavior through virally transduced ivermectin receptors.
Frontiers in Molecular Neuroscience
Vitenskapelig artikkel
-
Eilert-Olsen, Martine;
Hjukse, Jarand Berg;
Thoren, Anna;
Tang, Wannan;
Enger, Rune;
Jensen, Vidar;
Pettersen, Klas Henning;
Nagelhus, Erlend Arnulf.
(2019)
Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions.
Glia
Vitenskapelig artikkel
-
Engin, Elif;
Bakhurin, Konstantin I.;
Smith, Kiersten S,;
Hines, Rochelle M.;
Reynolds, Lauren M.;
Tang, Wannan;
Sprengel, Rolf;
Moss, Stephen J.;
Rudolph, Uwe.
(2014)
Neural basis of benzodiazepine reward: Requirement for α2 containing GABA a receptors in the nucleus accumbens.
Neuropsychopharmacology
Vitenskapelig artikkel