Per Bruheim
Om
Bruheim group focuses on Deep Phenotyping of prokaryotic and eukaryotic model systems using Advanced Cultivation Technology and Mass Spectrometry based Metabolomics, Fluxomics and Lipidomics (https://www.ntnu.edu/ibt/research/micphys#/view/about). Bruheim is scientific leader of the NT faculty Mass Spectrometry lab (http://www.ntnu.edu/nt-mslab). We have developed a suite of target and non-target MS methods (http://www.ntnu.edu/nt-mslab/metabolomics) which we apply on a range of biological model systems and research questions.
Teaching
Bruheim is leader of the 2-years and 5-years study programs in Biotechnology (MSBIOTECH and MBIOT5). He teaches in TBT4140 Biochemical Engineering, TBT4110 Microbiology, TKP4170/71 Process Designs, Projects Biochemical Engineering Plant Design, BT8120 Prokaryote Molecular Biology and Synthetic Biology, MEDT8010 Metabolomics - Methods and Applications
Current projects:
Trond Mohn Stiftelse: “Targeting AMR by inhibition of bacterial stress responses” (2019-2023)
NTNU Biotechnology programme: “Chemically defined cell culture media” (2019-2022)
NTNU IBT PhD: “Inhibition of antibiotic resistance development through targeting bacterial translesion synthesis mechanism with novel peptide drugs” (2017-2022)
8-10 ad hoc Metabolomics/ Fluxomics Lipidomics projects (NT-faculty, NTNU, National, International)
Publikasjoner
2023
-
Garcia Calvo, Laura;
Rane, Divyata Vilas;
Everson, Nikalet;
Humlebrekk, Sigurd Tømmerberg;
Mathiassen, Lise Femanger;
Mæhlum, Astfrid Helene Morka;
Malmo, Jostein;
Bruheim, Per.
(2023)
Central carbon metabolite profiling reveals vector-associated differences in the recombinant protein production host Escherichia coli BL21.
Frontiers in Chemical Engineering.
Vitenskapelig artikkel
-
Thorfinnsdottir, Lilja Brekke;
Bø, Gaute Hovde;
Booth, James Alexander;
Bruheim, Per.
(2023)
Survival of Escherichia coli after high-antibiotic stress is dependent on both the pregrown physiological state and incubation conditions.
Frontiers in Microbiology.
Vitenskapelig artikkel
-
Thorfinnsdottir, Lilja Brekke;
Garcia Calvo, Laura;
Bø, Gaute Hovde;
Bruheim, Per;
Røst, Lisa Marie Ivarsdatter.
(2023)
Optimized Fast Filtration-based Sampling and Extraction Enables Precise and Absolute Quantification of the Escherichia coli Central Carbon Metabolome.
Metabolites.
volum 13 (2).
Vitenskapelig artikkel
2022
-
Carracedo Huroz, Sergio;
Lirussi, Lisa;
Alsøe, Lene;
Segers, Filip;
Wang, Changliang;
Bartosova, Zdenka;
Bohov, Pavol;
Tekin, Nuriye Basdag;
Kong, Xiang Yi;
Esbensen, Qin Ying;
Chen, Liang;
Wennerström, Anna Berit;
Kroustallaki, Pinelopi;
Ceolotto, Deborah;
Tönjes, Anke;
Berge, Rolf Kristian;
Bruheim, Per;
Wong, Garry;
Böttcher, Yvonne;
Halvorsen, Bente;
Nilsen, Hilde.
(2022)
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
DNA Repair.
volum 120.
Vitenskapelig artikkel
-
Jang, Mi;
Pete, Ellen Sofie;
Bruheim, Per.
(2022)
The impact of serum-free culture on HEK293 cells: From the establishment of suspension and adherent serum-free adaptation cultures to the investigation of growth and metabolic profiles.
Frontiers in Bioengineering and Biotechnology.
Vitenskapelig artikkel
-
Jang, Mi;
Scheffold, Jana;
Bruheim, Per.
(2022)
Isolation and cultivation of primary muscle cells from Lobster (Homarus gammarus).
In vitro Cellular & Developmental Biology-Animal.
volum 58 (6).
Vitenskapelig artikkel
-
Jang, Mi;
Scheffold, Jana;
Røst, Lisa M.;
Cheon, Hyejeong;
Bruheim, Per.
(2022)
Serum-free cultures of C2C12 cells show different muscle phenotypes which can be estimated by metabolic profiling.
Scientific Reports.
volum 12.
Vitenskapelig artikkel
-
Kumar, Kanhaiya;
Bruheim, Per.
(2022)
A comparative study at bioprocess and metabolite levels of superhost strain Streptomyces coelicolor M1152 and its derivative M1581 heterologously expressing chloramphenicol biosynthetic gene cluster.
Biotechnology and Bioengineering.
volum 119.
Vitenskapelig artikkel
-
Kumar, Kanhaiya;
Bruheim, Per.
(2022)
Nutrient-depended metabolic switching during batch cultivation of Streptomyces coelicolor explored with absolute quantitative mass spectrometry based metabolite profiling.
3 Biotech.
volum 12.
Vitenskapelig artikkel
-
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim;
Bruheim, Per;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics.
volum 11 (8).
Vitenskapelig artikkel
-
Rau, E-Ming;
Bartosova, Zdenka;
Kristiansen, Kåre Andre;
Aasen, Inga Marie;
Bruheim, Per;
Ertesvåg, Helga.
(2022)
Overexpression of two new acyl-CoA:diacylglycerol acyltransferase 2-like acyl-CoA:sterol acyltransferases enhanced squalene accumulation in Aurantiochytrium limacinum.
Frontiers in Microbiology.
volum 13.
Vitenskapelig artikkel
-
Røst, Lisa M.;
Louet, Claire;
Bruheim, Per;
Flo, Trude Helen;
Gidon, Alexandre.
(2022)
Pyruvate Supports RET-Dependent Mitochondrial ROS Production to Control Mycobacterium avium Infection in Human Primary Macrophages.
Frontiers in Immunology.
volum 13.
Vitenskapelig artikkel
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per;
Otterlei, Marit.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene.
Vitenskapelig artikkel
-
Simensen, Vetle;
Schulz, Christian;
Karlsen, Emil;
Bråtelund, Signe;
Burgos, Idun Maria Tokvam;
Thorfinnsdottir, Lilja Brekke;
Garcia Calvo, Laura;
Bruheim, Per;
Almaas, Eivind.
(2022)
Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling.
PLOS ONE.
volum 17 (1).
Vitenskapelig artikkel
2021
-
Abdollahi, Pegah;
Vandsemb, Esten;
Elsaadi, Samah;
Røst, Lisa Marie;
Yang, Rui;
Hjort, Magnus Aassved;
Andreassen, Trygve;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rø, Torstein Baade;
Sponaas, Anne-Marit;
Moestue, Siver Andreas;
Bruheim, Per;
Børset, Magne.
(2021)
Phosphatase of Regenerating Liver-3 Regulates Cancer Cell Metabolism in Multiple Myeloma.
The FASEB Journal.
Vitenskapelig artikkel
-
Bartosova, Zdenka;
Ertesvåg, Helga;
Nyfløt, Eirin Lishaugen;
Kämpe, Kristoffer;
Aasen, Inga Marie;
Bruheim, Per.
(2021)
Combined Metabolome and Lipidome analyses for in-depth characterization of lipid accumulation in the DHA producing Aurantiochytrium sp. T66.
Metabolites.
volum 11 (3).
Vitenskapelig artikkel
-
Bartosova, Zdenka;
Villa Gonzalez, Susana;
Voigt, Andre;
Bruheim, Per.
(2021)
High throughput semi-quantitative UHPSFC-MS/MS lipid profiling and lipid class determination.
Journal of Chromatographic Science.
volum 59 (7).
Vitenskapelig artikkel
-
Fuchino, Katsuya;
Chan, Helena;
Hwang, Ling Chin;
Bruheim, Per.
(2021)
The Ethanologenic bacterium Zymomonas mobilis divides asymmetrically and exhibits heterogeneity in DNA content.
Applied and Environmental Microbiology.
volum 87 (6).
Vitenskapelig artikkel
-
Gidon, Alexandre;
Louet, Claire;
Røst, Lisa M.;
Bruheim, Per;
Flo, Trude Helen.
(2021)
The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages.
mBio.
volum 12 (5).
Vitenskapelig artikkel
-
Jin, Yang;
Harvey, Thomas Nelson;
Bartosova, Zdenka;
Hassani, Sahar;
Bruheim, Per;
Sandve, Simen Rød;
Vik, Jon Olav.
(2021)
Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon.
Journal of Agricultural and Food Chemistry.
volum 69 (12).
Vitenskapelig artikkel
-
Kumar, Kanhaiya;
Bruheim, Per.
(2021)
Large dependency of intracellular NAD and CoA pools on cultivation conditions in Saccharomyces cerevisiae.
BMC Research Notes.
volum 14 (1).
Vitenskapelig artikkel
-
Kumar, Kanhaiya;
Venkatraman, Vishwesh;
Bruheim, Per.
(2021)
Adaptation of central metabolite pools to variations in growth rate and cultivation conditions in Saccharomyces cerevisiae.
Microbial Cell Factories.
Vitenskapelig artikkel
-
Nilsen, Mona Synnøve;
Lindquist, Carine;
Stafsnes, Marit Hallvardsdotter;
Bjørndal, Bodil;
Bruheim, Per;
Aloysius, Thomas Aquinas;
Nygård, Ottar;
Skorve, Jon;
Madsen, Lise;
Dankel, Simon E Nitter;
Berge, Rolf Kristian.
(2021)
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.
volum 1866 (4).
Vitenskapelig artikkel
-
Pedersen, Eilif;
Eitungjerde, Sara;
André, Thea Harnes;
Bruheim, Per;
Grønflaten, Lars Trovatten;
Gundersen, Ingeborg Nævdal;
Hartnik, Lukas;
Kraemer, Frank Alexander;
Sigurjónsson, Jóhannes B.;
Torvatn, Tim Kristian Andreas.
(2021)
Fremtidens teknologistudier (FTS), grupperapport: A3 - 5-årig master.
2021.
Rapport
-
Rutkis, Reinis;
Strazdina, Inese;
Lasa, Zane;
Bruheim, Per;
Kalnenieks, Uldis.
(2021)
Ethanologenesis and respiration in a pyruvate decarboxylase-deficient Zymomonas mobilis.
BMC Research Notes.
volum 14.
Vitenskapelig artikkel
-
Skedsmo, Fredrik;
Espenes, Arild;
Tranulis, Michael A.;
Matiasek, Kaspar;
Gunnes, Gjermund;
Bjerkås, Inge;
Moe, Lars;
Røed, Susan Skogtvedt;
Berendt, Mette;
Fredholm, Merete;
Rohdin, Cecilia;
Shelton, G. Diane;
Bruheim, Per;
Stafsnes, Marit Hallvardsdotter;
Bartosova, Zdenka;
Hermansen, Lene Cecilie;
Stigen, Øyvind;
Jäderlund, Karin Hultin.
(2021)
Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D.
Neuromuscular Disorders.
volum 31 (1).
Vitenskapelig artikkel
-
Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia;
Duodu, Samuel;
Bruheim, Per;
Otterlei, Marit.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules.
volum 11 (6).
Vitenskapelig artikkel
2020
-
Fontana, Diletta;
Mauri, Mario;
Renso, Rossella;
Docci, Mattia;
Crespiatico, Ilaria;
Røst, Lisa Marie;
Jang, Mi;
Niro, Antonio;
D’Aliberti, Deborah;
Massimino, Luca;
Bertagna, Mayla;
Zambrotta, Giovanni;
Bossi, Mario;
Citterio, Stefania;
Crescenzi, Barbara;
Fanelli, Francesca;
Cassina, Valeria;
Corti, Roberta;
Salerno, Domenico;
Nardo, Luca;
Chinello, Clizia;
Mantegazza, Francesco;
Mecucci, Cristina;
Magni, Fulvio;
Cavaletti, Guido;
Bruheim, Per;
Rea, Delphine;
Larsen, Steen;
Gambacorti-Passerini, Carlo;
Piazza, Rocco.
(2020)
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine.
Nature Communications.
volum 11.
Vitenskapelig artikkel
-
Fuchino, Katsuya;
Bruheim, Per.
(2020)
An assessment of serial co-cultivation approach for generating novel Zymomonas mobilis strains.
BMC Research Notes.
volum 13.
Vitenskapelig artikkel
-
Fuchino, Katsuya;
Bruheim, Per.
(2020)
Increased salt tolerance in Zymomonas mobilis strain generated by adaptative evolution.
Microbial Cell Factories.
volum 19 (1).
Vitenskapelig artikkel
-
Fuchino, Katsuya;
Kalnenieks, Uldis;
Rutkis, Reinis;
Grube, Mara;
Bruheim, Per.
(2020)
Metabolic Profiling of Glucose-Fed Metabolically Active Resting Zymomonas mobilis Strains.
Metabolites.
volum 10 (81).
Vitenskapelig artikkel
-
Røst, Lisa Marie;
Darestani, Armaghan Shafaei;
Fuchino, Katsuya;
Bruheim, Per.
(2020)
Zwitterionic HILIC tandem mass spectrometry with isotope dilution for rapid, sensitive and robust quantification of pyridine nucleotides in biological extracts.
Journal of chromatography. B.
volum 1144.
Vitenskapelig artikkel
-
Røst, Lisa Marie;
Thorfinnsdottir, Lilja Brekke;
Kumar, Kanhaiya;
Fuchino, Katsuya;
Langørgen, Ida Eide;
Bartosova, Zdenka;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2020)
Absolute Quantification of the Central Carbon Metabolome in Eight Commonly Applied Prokaryotic and Eukaryotic Model Systems.
Metabolites.
volum 10 (74).
Vitenskapelig artikkel
2019
-
Kalnenieks, Uldis;
Balodite, Elina;
Strahler, Steffi;
Strazdina, Inese;
Rex, Julia;
Pentjuss, Agris;
Fuchino, Katsuya;
Bruheim, Per;
Rutkis, Reinis;
Pappas, Katherine M.;
Poole, Robert K.;
Sawodny, Oliver;
Bettenbrock, Katja.
(2019)
Improvement of acetaldehyde production in Zymomonas mobilis by engineering of its aerobic metabolism.
Frontiers in Microbiology.
volum 10.
Vitenskapelig artikkel
-
Navarro, Miguel Octavio Perez;
Simionato, Ane Stefano;
Perez, Juan Carlos Bedoya;
Barazetti, Andre Riedi;
Emiliano, Janaina;
Niekawa, Erika Tyemi Goya;
Andreata, Matheus Felipe de Lima;
Modolon, Fluvio;
Dealis, Mickely Liuti;
Araujo, Eduardo Jose de Almeida;
Carlos, Thalita Massi;
Scarpelim, Odair Jose;
Silva, Denise Brentan da;
Chryssafidis, Andreas Lazaros;
Bruheim, Per;
Andrade, Galdino.
(2019)
Fluopsin C for treating multidrug-resistant infections: In vitro activity aganist clinically important strains and in vivo efficacy against carbapenemase-producing Klebsiella pneumoniae.
Frontiers in Microbiology.
volum 10.
Vitenskapelig artikkel
-
Skedsmo, Fredrik Strebel;
Malachin, Giulia;
Våge, Dag Inge;
Hammervold, Mie Marie;
Salvesen, Øyvind;
Ersdal, Cecilie;
Ranheim, Birgit;
Stafsnes, Marit Hallvardsdotter;
Bartosova, Zdenka;
Bruheim, Per;
Jäderlund, Karin Hultin;
Matiasek, Kaspar;
Espenes, Arild;
Tranulis, Michael A..
(2019)
Demyelinating polyneuropathy in goats lacking prion protein.
The FASEB Journal.
volum 34 (2).
Vitenskapelig artikkel
-
Volkova, Yulia A.;
Averina, Elena B.;
Vasilenko, Dmitry A;
Sedenkova, Kseniya N;
Grishin, Yuri K.;
Bruheim, Per;
Kuznetsova, Tamara S.;
Zefirov, Nikolai S..
(2019)
Unexpected Heterocyclization of Electrophilic Alkenes by Tetranitromethane in the Presence of Triethylamine. Synthesis of 5-Nitroisoxazoles.
Journal of Organic Chemistry.
volum 84 (6).
Vitenskapelig artikkel
-
Øvrehus, Marius Altern;
Bruheim, Per;
Ju, Wenjun;
Zelnick, Leila R.;
Langlo, Knut Asbjørn Rise;
Sharma, Kumar;
de Boer, Ian H.;
Hallan, Stein.
(2019)
Gene expression studies and targeted metabolomics reveal disturbed serine, methionine, and tyrosine metabolism in early hypertensive nephrosclerosis.
Kidney International Reports.
volum 4 (2).
Vitenskapelig artikkel
2018
-
Johansen, Finn-Eirik;
Brautaset, Trygve;
Aune, Marie Hjelmseth;
Patriksson, Alexandra;
Falkenberg, Liv Eggset;
Kleppe, Rune;
Dick, Gunnar;
Strand, Berit Løkensgard;
Eijsink, Vincent;
Røyne, Anja;
Goksøyr, Anders;
Svendsen, John Sigurd Mjøen;
Fyhn, Marianne;
Vik, Jon Olav;
Wentzel, Alexander;
Aksnes, Astrid;
Bruheim, Per;
Carlsen, Sven Magnus;
Åm, Heidrun.
(2018)
Centre for Digital Life Norway - Annual report 2017.
2018.
Rapport
-
Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn;
Otterlei, Marit.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio.
volum 8 (7).
Vitenskapelig artikkel
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh;
Røst, Lisa Marie;
Misund, Kristine;
Andreassen, Trygve;
Melø, Torun Margareta;
Bartosova, Zdenka;
Bruheim, Per;
Otterlei, Marit.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients.
volum 10 (4).
Vitenskapelig artikkel
-
Stafsnes, Marit Hallvardsdotter;
Røst, Lisa Marie;
Bruheim, Per.
(2018)
Improved phosphometabolome profiling applying isotope dilution strategy and capillary ion chromatography-tandem mass spectrometry.
Journal of chromatography. B.
volum 1083.
Vitenskapelig artikkel
-
Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri;
Liabakk, Nina-Beate;
Gederaas, Odrun Arna;
Viset, Trond;
Arum, Carl-Jørgen;
Bruheim, Per;
Otterlei, Marit.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget.
volum 9 (65).
Vitenskapelig artikkel
2015
-
Giskeødegård, Guro F.;
Hansen, Ailin Falkmo;
Bertilsson, Helena;
Villa Gonzalez, Susana;
Kristiansen, Kåre Andre;
Bruheim, Per;
Mjøs, Svein Are;
Angelsen, Anders;
Bathen, Tone Frost;
Tessem, May-Britt.
(2015)
Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia.
British Journal of Cancer.
volum 113.
Vitenskapelig artikkel
-
Janecková, Hana;
Kalivodova, Alzbeta;
Najdekr, Lukas;
Friedecký, David;
Hron, Karel;
Bruheim, Per;
Adam, Tomás.
(2015)
Untargeted metabolomic analysis of urine samples in the diagnosis of some inherited metabolic disorders.
Biomedical Papers of the Faculty of Medicine of Palacky University.
volum 159 (4).
Vitenskapelig artikkel
-
Kvitvang, Hans Fredrik Nyvold;
Bruheim, Per.
(2015)
Fast filtration sampling protocol for mammalian suspension cells tailored for phosphometabolome profiling by capillary ion chromatography - tandem mass spectrometry.
Journal of chromatography. B.
volum 998-999.
Vitenskapelig artikkel
-
Lien, Stina Katrine;
Niedenführ, Sebastian;
Sletta, Håvard;
Nöh, Katharina;
Bruheim, Per.
(2015)
Fluxome study of Pseudomonas fluorescens reveals major reorganisation of carbon flux through central metabolic pathways in response to inactivation of the anti-sigma factor MucA.
BMC Systems Biology.
volum 9:6.
Vitenskapelig artikkel
-
Mühlroth, Alice;
Assimi, AE;
Røkke, Gunvor;
Despres, Julie;
Winge, Per;
Bruheim, Per;
Hohmann-Marriott, Martin Frank;
Vadstein, Olav;
Bones, Atle M..
(2015)
Transcriptional regulation of lipid accumulation in phosphorus limited Nannochloropsis oceanica.
European journal of phycology.
volum 50.
Sammendrag/abstract
-
Sreevidya, Meesala;
Gopalakrishnan, Subramaniam;
Melø, Torun Margareta;
Simic, Nebojsa;
Bruheim, Per;
Sharma, Mamta;
Srinivas, Vadlamudi;
Alekhya, Gottumukkala.
(2015)
Biological control of Botrytis cinerea and plant growth promotion potential by Penicillim citrinum in chickpea (Cicer arietinum L.).
Biocontrol science and technology (Print).
volum 25 (7).
Vitenskapelig artikkel
2014
-
Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen;
Otterlei, Marit.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology.
volum 7 (6).
Vitenskapelig artikkel
-
Kvitvang, Hans Fredrik Nyvold;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2014)
Assessment of capillary anion exchange ion chromatography tandem mass spectrometry for the quantitative profiling of the phosphometabolome and organic acids in biological extracts.
Journal of Chromatography A.
volum 1370.
Vitenskapelig artikkel
-
Kvitvang, Hans Fredrik Nyvold;
Kristiansen, Kåre Andre;
Lien, Stina Katrine;
Bruheim, Per.
(2014)
Quantitative Analysis of Amino and Organic Acids by Methyl Chloroformate Derivatization and GC-MS/MS Analysis.
Mass Spectrometry in Metabolomics: Methods and Protocols.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Pettersen, Ragnhild;
Johnsen, Geir;
Bruheim, Per;
Andreassen, Trygve.
(2014)
Development of hyperspectral imaging as a bio-optical taxonomic tool for pigmented marine organisms.
Organisms Diversity & Evolution.
volum 14 (2).
Vitenskapelig artikkel
2013
-
Borgos, Sven Even F.;
Bordel, Sergio;
Sletta, Håvard;
Ertesvåg, Helga;
Jakobsen, Øyvind Mejdell;
Bruheim, Per;
Ellingsen, Trond Erling;
Nielsen, Jens;
Valla, Svein.
(2013)
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling.
BMC Systems Biology.
volum 7 (19).
Vitenskapelig artikkel
-
Bruheim, Per;
Kvitvang, Hans Fredrik Nyvold;
Villas-Boas, Silas G..
(2013)
Stable isotope coded derivatizing reagents as internal standards in metabolite profiling.
Journal of Chromatography A.
volum 1296.
Vitenskapelig oversiktsartikkel/review
-
Lien, Stina Katrine;
Sletta, Håvard;
Ellingsen, Trond Erling;
Valla, Svein;
Correa, Elon;
Goodacre, Royston;
Vernstad, Kai;
Borgos, Sven Even F.;
Bruheim, Per.
(2013)
Investigating alginate production and carbon utilization in Pseudomonas fluorescens SBW25 using mass spectrometry-based metabolic profiling.
Metabolomics.
volum 9 (2).
Vitenskapelig artikkel
-
Stafsnes, Marit Hallvardsd;
Bruheim, Per.
(2013)
Pigmented Marine Heterotrophic Bacteria: Occurrence, Diversity, and Characterization of Pigmentation.
Marine Biomaterials: Characterization, Isolation and Applications.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Stafsnes, Marit Hallvardsd;
Dybwad, Marius;
Brunsvik, Anders;
Bruheim, Per.
(2013)
Large scale MALDI-TOF MS based taxa identification to identify novel pigment producers in a marine bacterial culture collection.
Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology.
volum 103 (3).
Vitenskapelig artikkel
2012
-
Almaas, Eivind;
Bruheim, Per;
Lale, Rahmi;
Valla, Svein.
(2012)
Dynamics and robustness of metabolic networks: A systems biology review of Escherichia coli metabolism.
Systems Microbiology - Current Topics and Applications.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Dybwad, Marius;
Granum, Per Einar;
Bruheim, Per;
Blatny, Janet Martha.
(2012)
Characterization of airborne bacteria at an underground subway station.
Applied and Environmental Microbiology.
volum 78 (6).
Vitenskapelig artikkel
-
Elde, Anette;
Pettersen, Ragnhild;
Bruheim, Per;
Järnegren, Johanna;
Johnsen, Geir.
(2012)
Pigmentation and Spectral Absorbance Signatures in Deep-Water Corals from the Trondheimsfjord, Norway.
Marine Drugs.
volum 10 (6).
Vitenskapelig artikkel
-
Janecková, Hana;
Hron, Karel;
Wojtowicz, Petr;
Hlídková, Eva;
Baresová, Anna;
Friedecký, David;
Zídková, Lenka;
Hornik, Petr;
Behúlová, Darina;
Procházková, Dagmar;
Vinohradská, Hana;
Pesková, Karolína;
Bruheim, Per;
Smolka, Vratislav;
St’astná, Sylvie;
Adam, Tomás.
(2012)
Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders.
Journal of Chromatography A.
volum 1226.
Vitenskapelig artikkel
-
Lien, Stina Katrine;
Kvitvang, Hans Fredrik Nyvold;
Bruheim, Per.
(2012)
Utilization of a deuterated derivatization agent to synthesize internal standards for gas chromatography-tandem mass spectrometry quantification of silylated metabolites.
Journal of Chromatography A.
volum 1247.
Vitenskapelig artikkel
-
Tøndervik, Anne;
Bruheim, Per;
Berg, Laila;
Ellingsen, Trond Erling;
Kotlar, Hans Kristian;
Valla, Svein;
Throne-Holst, Mimmi.
(2012)
Ralstonia sp U2 naphthalene dioxygenase and Comamonas sp JS765 nitrobenzene dioxygenase show differences in activity towards methylated naphthalenes.
Journal of Bioscience and Bioengineering.
volum 113 (2).
Vitenskapelig artikkel
-
Wentzel, Alexander;
Bruheim, Per;
Øverby, Anders;
Jakobsen, Øyvind Mejdell;
Sletta, Håvard;
Omara, Walid A.M.;
Hodgson, David A.;
Ellingsen, Trond Erling.
(2012)
Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2).
BMC Systems Biology.
volum 6 (59).
Vitenskapelig artikkel
-
Wentzel, Alexander;
Sletta, Håvard;
Wellington, E.M.H.;
Ellingsen, Trond Erling;
Bruheim, Per.
(2012)
Intracellular metabolite pool changes in response to nutrient depletion induced metabolic switching in Streptomyces coelicolor.
Metabolites.
volum 2.
Vitenskapelig artikkel
-
Wojtowicz, Petr;
Zrostlíková, Jitka;
Šťastná, Veronika;
Dostálová, Eva;
Zídková, Lenka;
Bruheim, Per;
Adam, Tomáš.
(2012)
Comprehensive Two-Dimensional Gas Chromatography Coupled to Time-of-Flight Mass Spectrometry in Human Metabolomics.
Gas Chromatography – Biochemicals, Narcotics and Essential Oils.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
2011
-
Bruheim, Per.
(2011)
“We focus most on the approximately 2000 baker's yeast genes that are closest to human genes.”.
Gemini.
volum spring.
Populærvitenskapelig artikkel
-
Klinkenberg, Geir;
Sletta, Håvard;
Fjærvik, Espen;
Zahlsen, Kolbjørn;
Bruheim, Per.
(2011)
Two-dimensional LC-MS fractioning and cross-matching of mass spectrometric data for rational identification of bioactive compounds in crude extracts.
Journal of Separation Science.
volum 34 (23).
Vitenskapelig artikkel
-
Kvitvang, Hans Fredrik Nyvold;
Andreassen, Trygve;
Adam, Tomas;
Villas-Boas, Silas G.;
Bruheim, Per.
(2011)
Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids.
Analytical Chemistry.
volum 83.
Vitenskapelig artikkel
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar;
Otterlei, Marit;
Bruheim, Per.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods.
volum 87 (3).
Vitenskapelig artikkel
-
Vijayabharathi, Rajendran;
Bruheim, Per;
Andreassen, Trygve;
Raja, Duraisamy Senthil;
Devi, Palanisamy Bruntha;
Sathyabama, Sathyaseelan;
Priyadarisini, Venkatesan Brindha.
(2011)
Assessment of resistomycin, as an anticancer compound isolated and characterized from Streptomyces aurantiacus AAA5.
Journal of Microbiology.
volum 49 (6).
Vitenskapelig artikkel
2010
-
Bruheim, Per.
(2010)
Gjær som pasienter.
Gemini.
volum 4.
Populærvitenskapelig artikkel
-
Bruheim, Per.
(2010)
Med gjær som kreftpasient.
Forskning.no.
publications.INTERVJUSKRIFTL
-
Mørkved, Eva Henmo;
Andreassen, Trygve;
Fröhlich, Roland;
Mo, Frode;
Bruheim, Per.
(2010)
Unsymmetrical zinc azaphthalocyanines, peripherally substituted with thiophen-2-yl and 2-functionalized phenoxy groups.
Polyhedron.
volum 29 (17).
Vitenskapelig artikkel
-
Netzer, Roman;
Stafsnes, Marit Hallvardsdotter;
Andreassen, Trygve;
Goksøyr, Audun;
Bruheim, Per;
Brautaset, Trygve.
(2010)
Biosynthetic Pathway for g-Cyclic Sarcinaxanthin in Micrococcus luteus: Heterologous Expression and Evidence for Diverse and Multiple Catalytic Functions of C50 Carotenoid Cyclases.
Journal of Bacteriology.
volum 192 (21).
Vitenskapelig artikkel
-
Nieselt, Kay;
Battke, Florian;
Herbig, Alexander;
Bruheim, Per;
Wentzel, Alexander;
Jakobsen, Øyvind Mejdell;
Sletta, Håvard;
Alam, Mohammad T.;
Merlo, Maria E.;
Moore, Jonathan;
Omara, Walid A.M.;
Morrissey, Edward R.;
Juarez-Hermosillo, Miguel A.;
Rodríguez-García, Antonio;
Nentwich, Merle;
Thomas, Louise;
Iqbal, Mudassar;
Legaie, Roxane;
Gaze, William H.;
Challis, Gregory L.;
Jansen, Ritsert C.;
Dijkhuizen, Lubbert;
Rand, David A.;
Wild, David L.;
Bonin, Michael;
Reuther, Jens;
Wohlleben, Wolfgang;
Smith, Margaret C.M.;
Burroughs, Nigel J.;
Martín, Juan F.;
Hodgson, David A.;
Takano, Eriko;
Breitling, Rainer;
Ellingsen, Trond Erling;
Wellington, Elisabeth M.H..
(2010)
The dynamic architecture of the metabolic switch in Streptomyces coelicolor.
BMC Genomics.
volum 11.
Vitenskapelig artikkel
-
Stafsnes, Marit Hallvardsdotter;
Josefsen, Kjell D.;
Kildahl-Andersen, Geir;
Valla, Svein;
Ellingsen, Trond E.;
Bruheim, Per.
(2010)
Isolation and Characterization of Marine Pigmented Bacteria from Norwegian Coastal Waters and Screening for Carotenoids with UVA-Blue Light Absorbing Properties.
Journal of Microbiology.
volum 48 (1).
Vitenskapelig artikkel
-
Volkova, Yulia A.;
Averina, Elena B.;
Grishin, Yuri K.;
Bruheim, Per;
Kuznetsova, Tamara S.;
Zefirov, Nikolai S..
(2010)
Unexpected Heterocyclization of Electrophilic Alkenes by Tetranitromethane in the Presence of Triethylamine. Synthesis of 3-Nitroisoxazoles.
Journal of Organic Chemistry.
volum 75 (9).
Vitenskapelig artikkel
2009
-
Jørgensen, Hanne;
Degnes, Kristin;
Sletta, Håvard;
Fjærvik, Espen;
Dikiy, Alexander;
Dikiy, Alexander;
Herfindal, Lars;
Bruheim, Per;
Klinkenberg, Geir;
Bredholt, Harald;
Nygård, Gyrid;
Doskeland, Stein Ove;
Ellingsen, Trond E.;
Zotchev, Sergey B..
(2009)
Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.
Chemistry and Biology.
volum 16 (10).
Vitenskapelig artikkel
-
Bruheim, Per;
Sletta, Håvard;
Zahlsen, Kolbjørn;
Bathen, Tone Frost;
Gribbestad, Ingrid S.
(2009)
metabolomics - et spennende verktøy i medisinsk og biologisk forskning.
NBS-nytt.
volum 1.
Populærvitenskapelig artikkel
-
Jørgensen, Hanne;
Fjærvik, Espen;
Hakvåg, Sigrid;
Bruheim, Per;
Bredholt, Harald;
Klinkenberg, Geir;
Ellingsen, Trond Erling;
Zotchev, Sergey.
(2009)
Candicidin Biosynthesis Gene Cluster Is Widely Distributed among Streptomyces spp. Isolated from the Sediments and the Neuston Layer of the Trondheim Fjord, Norway.
Applied and Environmental Microbiology.
volum 75 (10).
Vitenskapelig artikkel
-
Mørkved, Eva Henmo;
Andreassen, Trygve;
Bruheim, Per.
(2009)
Zinc azaphthalocyanines with pyridin-3-yloxy peripheral substituents.
Polyhedron.
volum 28 (13).
Vitenskapelig artikkel
-
Stockmann, Vegar;
Bakke, Jan Magnus;
Bruheim, Per;
Fiksdahl, Anne.
(2009)
Formation of new 4-isocyanobut-2-enenitriles by thermal ring cleavage of 3-pyridyl azides.
Tetrahedron.
volum 65 (18).
Vitenskapelig artikkel
2008
-
Fuglseth, Erik;
Sundby, Eirik;
Bruheim, Per;
Hoff, Bård Helge.
(2008)
Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols.
Tetrahedron: asymmetry.
volum 19 (16).
Vitenskapelig artikkel
-
Fuglseth, Erik;
Sundby, Eirik;
Bruheim, Per;
Hoff, Bård Helge.
(2008)
Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols.
Tetrahedron: asymmetry.
volum 19.
Vitenskapelig artikkel
-
Simon, Sebastien Charles;
Nordgård, Erland;
Bruheim, Per;
Sjøblom, Johan.
(2008)
Determination of C-80 tetra-acid content in calcium naphthenate deposits.
Journal of Chromatography A.
volum 1200.
Vitenskapelig artikkel
2007
-
Villas-Boas, Silas G.;
Bruheim, Per.
(2007)
Cold glycerol–saline: The promising quenching solution for accurate intracellular metabolite analysis of microbial cells.
Analytical Biochemistry.
volum 370.
Vitenskapelig artikkel
-
Villas-Boas, Silas G.;
Bruheim, Per.
(2007)
The potential of metabolomics tools in bioremediation studies.
Omics.
volum 11 (3).
Vitenskapelig oversiktsartikkel/review
2006
-
Holtan, Synnøve;
Bruheim, Per;
Skjåk-Bræk, Gudmund.
(2006)
Mode of action and subsite studies of the guluronan block forming mannuronan C-5 epimerases AlgE1 and AlgE6.
Biochemical Journal.
volum 395.
Vitenskapelig artikkel
-
Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy;
Bohr, Vilhelm A..
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science.
volum 119 (24).
Vitenskapelig artikkel
2005
-
Sletta, Håvard;
Bruheim, Per;
Borgos, Sven Even F.;
Sekurova, Olga;
Grasdalen, Hans;
Aune, Randi;
Zotchev, Sergey;
Ellingsen, Trond Erling.
(2005)
Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.
Antimicrobial Agents and Chemotherapy.
volum 49 (11).
Vitenskapelig artikkel
2004
-
Bruheim, Per;
Borgos, Sven Even F.;
Tsan, Pascale;
Sletta, Håvard;
Ellingsen, Trond Erling;
Lancelin, Jean-Marc;
Zotchev, Sergey.
(2004)
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
Antimicrobial Agents and Chemotherapy.
volum 48 (11).
Vitenskapelig artikkel
2003
-
Butler, M.;
Takano, E.;
Bruheim, Per;
Jovetic, Srdjan;
Marinelli, Flavia;
Bibb, Mervyn J..
(2003)
Deletion of scbA enhances antibiotic production in Streptomyces lividans.
Applied Microbiology and Biotechnology.
volum 61.
Vitenskapelig artikkel
-
Gunnarsson, Nina;
Bruheim, Per;
Nielsen, Jens.
(2003)
Production of the glycopeptide antibiotic A40926 by Nonomuraea sp. ATCC 39727: influence of medium composition in batch fermentation.
Journal of Industrial Microbiology & Biotechnology.
volum 30.
Vitenskapelig artikkel
-
Robin, J.;
Bruheim, Per;
Nielsen, M.L.;
Noorman, H.;
Nielsen, Jens.
(2003)
Continuous cultivations of a Pencillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetyoxycephalosporanic acid and byproduct formations.
Biotechnology and Bioengineering.
volum 83 (3).
Vitenskapelig artikkel
2002
-
Brautaset, Trygve;
Bruheim, Per;
Sletta, Håvard;
Hagen, Lars;
Ellingsen, Trond E.;
Strøm, Arne Reidar;
Valla, Svein;
Zotchev, Sergey.
(2002)
Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455.
Chemistry and Biology.
volum 9.
Vitenskapelig artikkel
-
Bredholt, Harald;
Bruheim, Per;
Potocky, Martin;
Eimhjellen, Kjell.
(2002)
Hydrophobicity development, alkane oxidation, and crude-oil emulsification in a Rhodococcus species.
Canadian Journal of Microbiology (print).
volum 48.
Vitenskapelig artikkel
-
Bruheim, Per;
Butler, M.;
Ellingsen, Trond E..
(2002)
A theoretical analysis of the biosynthesis of actinorhodin in a hyper-producing Streptomyces lividans strain cultivated on various carbon sources.
Applied Microbiology and Biotechnology.
volum 58.
Vitenskapelig artikkel
-
Bruheim, Per;
Sletta, Håvard;
Bibb, M.J.;
White, J.;
Levine, David William.
(2002)
High-yield actinorhodin production in fed-batch culture by a Streptomyces lividans strain overexpressing the pathway-specific activator gene actII-ORF4.
Journal of Industrial Microbiology & Biotechnology.
volum 28.
Vitenskapelig artikkel
-
Butler, M.;
Bruheim, Per;
Jovetic, Srdjan;
Marinelli, Flavia;
Postma, Pieter W.;
Bibb, Mervyn J..
(2002)
Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans.
Applied and Environmental Microbiology.
volum 68 (10).
Vitenskapelig artikkel
2000
-
Bruheim, Per.
(2000)
Metabolic engineering - fremtidens verktøy for utvikling av industrielle bioteknologiske prosesser?.
NBS-nytt.
Populærvitenskapelig artikkel
-
Bruheim, Per;
Eimhjellen, Kjell.
(2000)
Effects of non-ionic surfactants on the uptake and hydrolysis of fluoresceindiacetate by alkane-oxidizing bacteria.
Canadian Journal of Microbiology (print).
volum 46 (4).
Vitenskapelig artikkel
1999
-
Bruheim, Per;
Bredholt, Harald;
Eimhjellen, Kjell.
(1999)
Effects of surfactant mixtures, including Corexit 9527, on bacterial oxidation of acetate and alkanes in crude oil.
Applied and Environmental Microbiology.
volum 65 (4).
Vitenskapelig artikkel
1998
-
Bredholt, Harald;
Josefsen, Kjell;
Vatland, Arild;
Bruheim, Per;
Eimhjellen, Kjell.
(1998)
Emulsification of crude oil by an alkane-oxidizing Rhodococcus species isolated from seawater.
Canadian Journal of Microbiology (print).
volum 44.
Vitenskapelig artikkel
-
Bruheim, Per;
Eimhjellen, Kjell.
(1998)
Chemically emulsified crude oil as substrate for bacterial oxdidation : differences in species response.
Canadian Journal of Microbiology (print).
volum 44/1998.
Vitenskapelig artikkel
1997
-
Bruheim, Per;
Bredholt, Harald;
Eimhjellen, Kjell.
(1997)
Bacterial degradation of emulsified crude oil and the effect of various surfactants.
Canadian Journal of Microbiology (print).
volum 43.
Vitenskapelig artikkel
1996
-
Thu, Beate;
Bruheim, Per;
Espevik, Terje;
Smidsrød, Olav;
Soon-Shiong, P.;
Skjåk-Bræk, Gudmund.
(1996)
Alginate polycation microcapsules. I, Interaction between alginate and polycation.
Biomaterials.
volum 17.
Vitenskapelig artikkel
-
Thu, Beate;
Bruheim, Per;
Espevik, Terje;
Smidsrød, Olav;
Soon-Shiong, Patrick;
Skjåk-Bræk, Gudmund.
(1996)
Alginate polycation microcapsules. II, Some functional properties.
Biomaterials.
volum 17.
Vitenskapelig artikkel
1991
-
Stokke, Bjørn Torger;
Smidsrød, Olav;
Bruheim, Per;
Skjåk-Bræk, Gudmund.
(1991)
Distribution of uronate residues in alginate chains in relation to alginate gelling properties.
Macromolecules.
volum 24.
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Garcia Calvo, Laura;
Rane, Divyata Vilas;
Everson, Nikalet;
Humlebrekk, Sigurd Tømmerberg;
Mathiassen, Lise Femanger;
Mæhlum, Astfrid Helene Morka;
Malmo, Jostein;
Bruheim, Per.
(2023)
Central carbon metabolite profiling reveals vector-associated differences in the recombinant protein production host Escherichia coli BL21.
Frontiers in Chemical Engineering.
Vitenskapelig artikkel
-
Thorfinnsdottir, Lilja Brekke;
Bø, Gaute Hovde;
Booth, James Alexander;
Bruheim, Per.
(2023)
Survival of Escherichia coli after high-antibiotic stress is dependent on both the pregrown physiological state and incubation conditions.
Frontiers in Microbiology.
Vitenskapelig artikkel
-
Thorfinnsdottir, Lilja Brekke;
Garcia Calvo, Laura;
Bø, Gaute Hovde;
Bruheim, Per;
Røst, Lisa Marie Ivarsdatter.
(2023)
Optimized Fast Filtration-based Sampling and Extraction Enables Precise and Absolute Quantification of the Escherichia coli Central Carbon Metabolome.
Metabolites.
volum 13 (2).
Vitenskapelig artikkel
-
Carracedo Huroz, Sergio;
Lirussi, Lisa;
Alsøe, Lene;
Segers, Filip;
Wang, Changliang;
Bartosova, Zdenka;
Bohov, Pavol;
Tekin, Nuriye Basdag;
Kong, Xiang Yi;
Esbensen, Qin Ying;
Chen, Liang;
Wennerström, Anna Berit;
Kroustallaki, Pinelopi;
Ceolotto, Deborah;
Tönjes, Anke;
Berge, Rolf Kristian;
Bruheim, Per;
Wong, Garry;
Böttcher, Yvonne;
Halvorsen, Bente;
Nilsen, Hilde.
(2022)
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice.
DNA Repair.
volum 120.
Vitenskapelig artikkel
-
Jang, Mi;
Pete, Ellen Sofie;
Bruheim, Per.
(2022)
The impact of serum-free culture on HEK293 cells: From the establishment of suspension and adherent serum-free adaptation cultures to the investigation of growth and metabolic profiles.
Frontiers in Bioengineering and Biotechnology.
Vitenskapelig artikkel
-
Jang, Mi;
Scheffold, Jana;
Bruheim, Per.
(2022)
Isolation and cultivation of primary muscle cells from Lobster (Homarus gammarus).
In vitro Cellular & Developmental Biology-Animal.
volum 58 (6).
Vitenskapelig artikkel
-
Jang, Mi;
Scheffold, Jana;
Røst, Lisa M.;
Cheon, Hyejeong;
Bruheim, Per.
(2022)
Serum-free cultures of C2C12 cells show different muscle phenotypes which can be estimated by metabolic profiling.
Scientific Reports.
volum 12.
Vitenskapelig artikkel
-
Kumar, Kanhaiya;
Bruheim, Per.
(2022)
A comparative study at bioprocess and metabolite levels of superhost strain Streptomyces coelicolor M1152 and its derivative M1581 heterologously expressing chloramphenicol biosynthetic gene cluster.
Biotechnology and Bioengineering.
volum 119.
Vitenskapelig artikkel
-
Kumar, Kanhaiya;
Bruheim, Per.
(2022)
Nutrient-depended metabolic switching during batch cultivation of Streptomyces coelicolor explored with absolute quantitative mass spectrometry based metabolite profiling.
3 Biotech.
volum 12.
Vitenskapelig artikkel
-
Olsen, Cecilie Elisabeth;
Blindheim, Fredrik Heen;
Søgaard, Caroline Krogh;
Røst, Lisa M.;
Singleton, Amanda;
Bergum, Olaug Elisabeth Torheim;
Bruheim, Per;
Otterlei, Marit;
Sundby, Eirik;
Hoff, Bård Helge.
(2022)
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide.
Antibiotics.
volum 11 (8).
Vitenskapelig artikkel
-
Rau, E-Ming;
Bartosova, Zdenka;
Kristiansen, Kåre Andre;
Aasen, Inga Marie;
Bruheim, Per;
Ertesvåg, Helga.
(2022)
Overexpression of two new acyl-CoA:diacylglycerol acyltransferase 2-like acyl-CoA:sterol acyltransferases enhanced squalene accumulation in Aurantiochytrium limacinum.
Frontiers in Microbiology.
volum 13.
Vitenskapelig artikkel
-
Røst, Lisa M.;
Louet, Claire;
Bruheim, Per;
Flo, Trude Helen;
Gidon, Alexandre.
(2022)
Pyruvate Supports RET-Dependent Mitochondrial ROS Production to Control Mycobacterium avium Infection in Human Primary Macrophages.
Frontiers in Immunology.
volum 13.
Vitenskapelig artikkel
-
Røst, Lisa M.;
Ræder, Synnøve Brandt;
Olaisen, Camilla;
Søgaard, Caroline Krogh;
Sharma, Animesh;
Bruheim, Per;
Otterlei, Marit.
(2022)
PCNA regulates primary metabolism by scaffolding metabolic enzymes.
Oncogene.
Vitenskapelig artikkel
-
Simensen, Vetle;
Schulz, Christian;
Karlsen, Emil;
Bråtelund, Signe;
Burgos, Idun Maria Tokvam;
Thorfinnsdottir, Lilja Brekke;
Garcia Calvo, Laura;
Bruheim, Per;
Almaas, Eivind.
(2022)
Experimental determination of Escherichia coli biomass composition for constraint-based metabolic modeling.
PLOS ONE.
volum 17 (1).
Vitenskapelig artikkel
-
Abdollahi, Pegah;
Vandsemb, Esten;
Elsaadi, Samah;
Røst, Lisa Marie;
Yang, Rui;
Hjort, Magnus Aassved;
Andreassen, Trygve;
Misund, Kristine;
Slørdahl, Tobias Schmidt;
Rø, Torstein Baade;
Sponaas, Anne-Marit;
Moestue, Siver Andreas;
Bruheim, Per;
Børset, Magne.
(2021)
Phosphatase of Regenerating Liver-3 Regulates Cancer Cell Metabolism in Multiple Myeloma.
The FASEB Journal.
Vitenskapelig artikkel
-
Bartosova, Zdenka;
Ertesvåg, Helga;
Nyfløt, Eirin Lishaugen;
Kämpe, Kristoffer;
Aasen, Inga Marie;
Bruheim, Per.
(2021)
Combined Metabolome and Lipidome analyses for in-depth characterization of lipid accumulation in the DHA producing Aurantiochytrium sp. T66.
Metabolites.
volum 11 (3).
Vitenskapelig artikkel
-
Bartosova, Zdenka;
Villa Gonzalez, Susana;
Voigt, Andre;
Bruheim, Per.
(2021)
High throughput semi-quantitative UHPSFC-MS/MS lipid profiling and lipid class determination.
Journal of Chromatographic Science.
volum 59 (7).
Vitenskapelig artikkel
-
Fuchino, Katsuya;
Chan, Helena;
Hwang, Ling Chin;
Bruheim, Per.
(2021)
The Ethanologenic bacterium Zymomonas mobilis divides asymmetrically and exhibits heterogeneity in DNA content.
Applied and Environmental Microbiology.
volum 87 (6).
Vitenskapelig artikkel
-
Gidon, Alexandre;
Louet, Claire;
Røst, Lisa M.;
Bruheim, Per;
Flo, Trude Helen.
(2021)
The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages.
mBio.
volum 12 (5).
Vitenskapelig artikkel
-
Jin, Yang;
Harvey, Thomas Nelson;
Bartosova, Zdenka;
Hassani, Sahar;
Bruheim, Per;
Sandve, Simen Rød;
Vik, Jon Olav.
(2021)
Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon.
Journal of Agricultural and Food Chemistry.
volum 69 (12).
Vitenskapelig artikkel
-
Kumar, Kanhaiya;
Bruheim, Per.
(2021)
Large dependency of intracellular NAD and CoA pools on cultivation conditions in Saccharomyces cerevisiae.
BMC Research Notes.
volum 14 (1).
Vitenskapelig artikkel
-
Kumar, Kanhaiya;
Venkatraman, Vishwesh;
Bruheim, Per.
(2021)
Adaptation of central metabolite pools to variations in growth rate and cultivation conditions in Saccharomyces cerevisiae.
Microbial Cell Factories.
Vitenskapelig artikkel
-
Nilsen, Mona Synnøve;
Lindquist, Carine;
Stafsnes, Marit Hallvardsdotter;
Bjørndal, Bodil;
Bruheim, Per;
Aloysius, Thomas Aquinas;
Nygård, Ottar;
Skorve, Jon;
Madsen, Lise;
Dankel, Simon E Nitter;
Berge, Rolf Kristian.
(2021)
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.
volum 1866 (4).
Vitenskapelig artikkel
-
Rutkis, Reinis;
Strazdina, Inese;
Lasa, Zane;
Bruheim, Per;
Kalnenieks, Uldis.
(2021)
Ethanologenesis and respiration in a pyruvate decarboxylase-deficient Zymomonas mobilis.
BMC Research Notes.
volum 14.
Vitenskapelig artikkel
-
Skedsmo, Fredrik;
Espenes, Arild;
Tranulis, Michael A.;
Matiasek, Kaspar;
Gunnes, Gjermund;
Bjerkås, Inge;
Moe, Lars;
Røed, Susan Skogtvedt;
Berendt, Mette;
Fredholm, Merete;
Rohdin, Cecilia;
Shelton, G. Diane;
Bruheim, Per;
Stafsnes, Marit Hallvardsdotter;
Bartosova, Zdenka;
Hermansen, Lene Cecilie;
Stigen, Øyvind;
Jäderlund, Karin Hultin.
(2021)
Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D.
Neuromuscular Disorders.
volum 31 (1).
Vitenskapelig artikkel
-
Sumabe, Balagra Kasim;
Ræder, Synnøve Brandt;
Røst, Lisa M.;
Sharma, Animesh;
Donkor, Eric S.;
Mosi, Lydia;
Duodu, Samuel;
Bruheim, Per;
Otterlei, Marit.
(2021)
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.
Biomolecules.
volum 11 (6).
Vitenskapelig artikkel
-
Fontana, Diletta;
Mauri, Mario;
Renso, Rossella;
Docci, Mattia;
Crespiatico, Ilaria;
Røst, Lisa Marie;
Jang, Mi;
Niro, Antonio;
D’Aliberti, Deborah;
Massimino, Luca;
Bertagna, Mayla;
Zambrotta, Giovanni;
Bossi, Mario;
Citterio, Stefania;
Crescenzi, Barbara;
Fanelli, Francesca;
Cassina, Valeria;
Corti, Roberta;
Salerno, Domenico;
Nardo, Luca;
Chinello, Clizia;
Mantegazza, Francesco;
Mecucci, Cristina;
Magni, Fulvio;
Cavaletti, Guido;
Bruheim, Per;
Rea, Delphine;
Larsen, Steen;
Gambacorti-Passerini, Carlo;
Piazza, Rocco.
(2020)
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine.
Nature Communications.
volum 11.
Vitenskapelig artikkel
-
Fuchino, Katsuya;
Bruheim, Per.
(2020)
An assessment of serial co-cultivation approach for generating novel Zymomonas mobilis strains.
BMC Research Notes.
volum 13.
Vitenskapelig artikkel
-
Fuchino, Katsuya;
Bruheim, Per.
(2020)
Increased salt tolerance in Zymomonas mobilis strain generated by adaptative evolution.
Microbial Cell Factories.
volum 19 (1).
Vitenskapelig artikkel
-
Fuchino, Katsuya;
Kalnenieks, Uldis;
Rutkis, Reinis;
Grube, Mara;
Bruheim, Per.
(2020)
Metabolic Profiling of Glucose-Fed Metabolically Active Resting Zymomonas mobilis Strains.
Metabolites.
volum 10 (81).
Vitenskapelig artikkel
-
Røst, Lisa Marie;
Darestani, Armaghan Shafaei;
Fuchino, Katsuya;
Bruheim, Per.
(2020)
Zwitterionic HILIC tandem mass spectrometry with isotope dilution for rapid, sensitive and robust quantification of pyridine nucleotides in biological extracts.
Journal of chromatography. B.
volum 1144.
Vitenskapelig artikkel
-
Røst, Lisa Marie;
Thorfinnsdottir, Lilja Brekke;
Kumar, Kanhaiya;
Fuchino, Katsuya;
Langørgen, Ida Eide;
Bartosova, Zdenka;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2020)
Absolute Quantification of the Central Carbon Metabolome in Eight Commonly Applied Prokaryotic and Eukaryotic Model Systems.
Metabolites.
volum 10 (74).
Vitenskapelig artikkel
-
Kalnenieks, Uldis;
Balodite, Elina;
Strahler, Steffi;
Strazdina, Inese;
Rex, Julia;
Pentjuss, Agris;
Fuchino, Katsuya;
Bruheim, Per;
Rutkis, Reinis;
Pappas, Katherine M.;
Poole, Robert K.;
Sawodny, Oliver;
Bettenbrock, Katja.
(2019)
Improvement of acetaldehyde production in Zymomonas mobilis by engineering of its aerobic metabolism.
Frontiers in Microbiology.
volum 10.
Vitenskapelig artikkel
-
Navarro, Miguel Octavio Perez;
Simionato, Ane Stefano;
Perez, Juan Carlos Bedoya;
Barazetti, Andre Riedi;
Emiliano, Janaina;
Niekawa, Erika Tyemi Goya;
Andreata, Matheus Felipe de Lima;
Modolon, Fluvio;
Dealis, Mickely Liuti;
Araujo, Eduardo Jose de Almeida;
Carlos, Thalita Massi;
Scarpelim, Odair Jose;
Silva, Denise Brentan da;
Chryssafidis, Andreas Lazaros;
Bruheim, Per;
Andrade, Galdino.
(2019)
Fluopsin C for treating multidrug-resistant infections: In vitro activity aganist clinically important strains and in vivo efficacy against carbapenemase-producing Klebsiella pneumoniae.
Frontiers in Microbiology.
volum 10.
Vitenskapelig artikkel
-
Skedsmo, Fredrik Strebel;
Malachin, Giulia;
Våge, Dag Inge;
Hammervold, Mie Marie;
Salvesen, Øyvind;
Ersdal, Cecilie;
Ranheim, Birgit;
Stafsnes, Marit Hallvardsdotter;
Bartosova, Zdenka;
Bruheim, Per;
Jäderlund, Karin Hultin;
Matiasek, Kaspar;
Espenes, Arild;
Tranulis, Michael A..
(2019)
Demyelinating polyneuropathy in goats lacking prion protein.
The FASEB Journal.
volum 34 (2).
Vitenskapelig artikkel
-
Volkova, Yulia A.;
Averina, Elena B.;
Vasilenko, Dmitry A;
Sedenkova, Kseniya N;
Grishin, Yuri K.;
Bruheim, Per;
Kuznetsova, Tamara S.;
Zefirov, Nikolai S..
(2019)
Unexpected Heterocyclization of Electrophilic Alkenes by Tetranitromethane in the Presence of Triethylamine. Synthesis of 5-Nitroisoxazoles.
Journal of Organic Chemistry.
volum 84 (6).
Vitenskapelig artikkel
-
Øvrehus, Marius Altern;
Bruheim, Per;
Ju, Wenjun;
Zelnick, Leila R.;
Langlo, Knut Asbjørn Rise;
Sharma, Kumar;
de Boer, Ian H.;
Hallan, Stein.
(2019)
Gene expression studies and targeted metabolomics reveal disturbed serine, methionine, and tyrosine metabolism in early hypertensive nephrosclerosis.
Kidney International Reports.
volum 4 (2).
Vitenskapelig artikkel
-
Olaisen, Camilla;
Kvitvang, Hans Fredrik Nyvold;
Lee, Sungmin;
Almaas, Eivind;
Bruheim, Per;
Drabløs, Finn;
Otterlei, Marit.
(2018)
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.
FEBS Open Bio.
volum 8 (7).
Vitenskapelig artikkel
-
Petrovic, Voin;
Nepal, Anala;
Olaisen, Camilla;
Bachke, Siri;
Hira, Jonathan;
Søgaard, Caroline Krogh;
Røst, Lisa Marie;
Misund, Kristine;
Andreassen, Trygve;
Melø, Torun Margareta;
Bartosova, Zdenka;
Bruheim, Per;
Otterlei, Marit.
(2018)
Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.
Nutrients.
volum 10 (4).
Vitenskapelig artikkel
-
Stafsnes, Marit Hallvardsdotter;
Røst, Lisa Marie;
Bruheim, Per.
(2018)
Improved phosphometabolome profiling applying isotope dilution strategy and capillary ion chromatography-tandem mass spectrometry.
Journal of chromatography. B.
volum 1083.
Vitenskapelig artikkel
-
Søgaard, Caroline Krogh;
Blindheim, Augun;
Røst, Lisa Marie;
Petrovic, Voin;
Nepal, Anala;
Bachke, Siri;
Liabakk, Nina-Beate;
Gederaas, Odrun Arna;
Viset, Trond;
Arum, Carl-Jørgen;
Bruheim, Per;
Otterlei, Marit.
(2018)
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.
OncoTarget.
volum 9 (65).
Vitenskapelig artikkel
-
Giskeødegård, Guro F.;
Hansen, Ailin Falkmo;
Bertilsson, Helena;
Villa Gonzalez, Susana;
Kristiansen, Kåre Andre;
Bruheim, Per;
Mjøs, Svein Are;
Angelsen, Anders;
Bathen, Tone Frost;
Tessem, May-Britt.
(2015)
Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia.
British Journal of Cancer.
volum 113.
Vitenskapelig artikkel
-
Janecková, Hana;
Kalivodova, Alzbeta;
Najdekr, Lukas;
Friedecký, David;
Hron, Karel;
Bruheim, Per;
Adam, Tomás.
(2015)
Untargeted metabolomic analysis of urine samples in the diagnosis of some inherited metabolic disorders.
Biomedical Papers of the Faculty of Medicine of Palacky University.
volum 159 (4).
Vitenskapelig artikkel
-
Kvitvang, Hans Fredrik Nyvold;
Bruheim, Per.
(2015)
Fast filtration sampling protocol for mammalian suspension cells tailored for phosphometabolome profiling by capillary ion chromatography - tandem mass spectrometry.
Journal of chromatography. B.
volum 998-999.
Vitenskapelig artikkel
-
Lien, Stina Katrine;
Niedenführ, Sebastian;
Sletta, Håvard;
Nöh, Katharina;
Bruheim, Per.
(2015)
Fluxome study of Pseudomonas fluorescens reveals major reorganisation of carbon flux through central metabolic pathways in response to inactivation of the anti-sigma factor MucA.
BMC Systems Biology.
volum 9:6.
Vitenskapelig artikkel
-
Mühlroth, Alice;
Assimi, AE;
Røkke, Gunvor;
Despres, Julie;
Winge, Per;
Bruheim, Per;
Hohmann-Marriott, Martin Frank;
Vadstein, Olav;
Bones, Atle M..
(2015)
Transcriptional regulation of lipid accumulation in phosphorus limited Nannochloropsis oceanica.
European journal of phycology.
volum 50.
Sammendrag/abstract
-
Sreevidya, Meesala;
Gopalakrishnan, Subramaniam;
Melø, Torun Margareta;
Simic, Nebojsa;
Bruheim, Per;
Sharma, Mamta;
Srinivas, Vadlamudi;
Alekhya, Gottumukkala.
(2015)
Biological control of Botrytis cinerea and plant growth promotion potential by Penicillim citrinum in chickpea (Cicer arietinum L.).
Biocontrol science and technology (Print).
volum 25 (7).
Vitenskapelig artikkel
-
Gederaas, Odrun Arna;
Søgaard, Caroline Danielsen;
Viset, Trond;
Bachke, Siri;
Bruheim, Per;
Arum, Carl-Jørgen;
Otterlei, Marit.
(2014)
Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide.
Translational Oncology.
volum 7 (6).
Vitenskapelig artikkel
-
Kvitvang, Hans Fredrik Nyvold;
Kristiansen, Kåre Andre;
Bruheim, Per.
(2014)
Assessment of capillary anion exchange ion chromatography tandem mass spectrometry for the quantitative profiling of the phosphometabolome and organic acids in biological extracts.
Journal of Chromatography A.
volum 1370.
Vitenskapelig artikkel
-
Pettersen, Ragnhild;
Johnsen, Geir;
Bruheim, Per;
Andreassen, Trygve.
(2014)
Development of hyperspectral imaging as a bio-optical taxonomic tool for pigmented marine organisms.
Organisms Diversity & Evolution.
volum 14 (2).
Vitenskapelig artikkel
-
Borgos, Sven Even F.;
Bordel, Sergio;
Sletta, Håvard;
Ertesvåg, Helga;
Jakobsen, Øyvind Mejdell;
Bruheim, Per;
Ellingsen, Trond Erling;
Nielsen, Jens;
Valla, Svein.
(2013)
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling.
BMC Systems Biology.
volum 7 (19).
Vitenskapelig artikkel
-
Bruheim, Per;
Kvitvang, Hans Fredrik Nyvold;
Villas-Boas, Silas G..
(2013)
Stable isotope coded derivatizing reagents as internal standards in metabolite profiling.
Journal of Chromatography A.
volum 1296.
Vitenskapelig oversiktsartikkel/review
-
Lien, Stina Katrine;
Sletta, Håvard;
Ellingsen, Trond Erling;
Valla, Svein;
Correa, Elon;
Goodacre, Royston;
Vernstad, Kai;
Borgos, Sven Even F.;
Bruheim, Per.
(2013)
Investigating alginate production and carbon utilization in Pseudomonas fluorescens SBW25 using mass spectrometry-based metabolic profiling.
Metabolomics.
volum 9 (2).
Vitenskapelig artikkel
-
Stafsnes, Marit Hallvardsd;
Dybwad, Marius;
Brunsvik, Anders;
Bruheim, Per.
(2013)
Large scale MALDI-TOF MS based taxa identification to identify novel pigment producers in a marine bacterial culture collection.
Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology.
volum 103 (3).
Vitenskapelig artikkel
-
Dybwad, Marius;
Granum, Per Einar;
Bruheim, Per;
Blatny, Janet Martha.
(2012)
Characterization of airborne bacteria at an underground subway station.
Applied and Environmental Microbiology.
volum 78 (6).
Vitenskapelig artikkel
-
Elde, Anette;
Pettersen, Ragnhild;
Bruheim, Per;
Järnegren, Johanna;
Johnsen, Geir.
(2012)
Pigmentation and Spectral Absorbance Signatures in Deep-Water Corals from the Trondheimsfjord, Norway.
Marine Drugs.
volum 10 (6).
Vitenskapelig artikkel
-
Janecková, Hana;
Hron, Karel;
Wojtowicz, Petr;
Hlídková, Eva;
Baresová, Anna;
Friedecký, David;
Zídková, Lenka;
Hornik, Petr;
Behúlová, Darina;
Procházková, Dagmar;
Vinohradská, Hana;
Pesková, Karolína;
Bruheim, Per;
Smolka, Vratislav;
St’astná, Sylvie;
Adam, Tomás.
(2012)
Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders.
Journal of Chromatography A.
volum 1226.
Vitenskapelig artikkel
-
Lien, Stina Katrine;
Kvitvang, Hans Fredrik Nyvold;
Bruheim, Per.
(2012)
Utilization of a deuterated derivatization agent to synthesize internal standards for gas chromatography-tandem mass spectrometry quantification of silylated metabolites.
Journal of Chromatography A.
volum 1247.
Vitenskapelig artikkel
-
Tøndervik, Anne;
Bruheim, Per;
Berg, Laila;
Ellingsen, Trond Erling;
Kotlar, Hans Kristian;
Valla, Svein;
Throne-Holst, Mimmi.
(2012)
Ralstonia sp U2 naphthalene dioxygenase and Comamonas sp JS765 nitrobenzene dioxygenase show differences in activity towards methylated naphthalenes.
Journal of Bioscience and Bioengineering.
volum 113 (2).
Vitenskapelig artikkel
-
Wentzel, Alexander;
Bruheim, Per;
Øverby, Anders;
Jakobsen, Øyvind Mejdell;
Sletta, Håvard;
Omara, Walid A.M.;
Hodgson, David A.;
Ellingsen, Trond Erling.
(2012)
Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2).
BMC Systems Biology.
volum 6 (59).
Vitenskapelig artikkel
-
Wentzel, Alexander;
Sletta, Håvard;
Wellington, E.M.H.;
Ellingsen, Trond Erling;
Bruheim, Per.
(2012)
Intracellular metabolite pool changes in response to nutrient depletion induced metabolic switching in Streptomyces coelicolor.
Metabolites.
volum 2.
Vitenskapelig artikkel
-
Bruheim, Per.
(2011)
“We focus most on the approximately 2000 baker's yeast genes that are closest to human genes.”.
Gemini.
volum spring.
Populærvitenskapelig artikkel
-
Klinkenberg, Geir;
Sletta, Håvard;
Fjærvik, Espen;
Zahlsen, Kolbjørn;
Bruheim, Per.
(2011)
Two-dimensional LC-MS fractioning and cross-matching of mass spectrometric data for rational identification of bioactive compounds in crude extracts.
Journal of Separation Science.
volum 34 (23).
Vitenskapelig artikkel
-
Kvitvang, Hans Fredrik Nyvold;
Andreassen, Trygve;
Adam, Tomas;
Villas-Boas, Silas G.;
Bruheim, Per.
(2011)
Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids.
Analytical Chemistry.
volum 83.
Vitenskapelig artikkel
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar;
Otterlei, Marit;
Bruheim, Per.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods.
volum 87 (3).
Vitenskapelig artikkel
-
Vijayabharathi, Rajendran;
Bruheim, Per;
Andreassen, Trygve;
Raja, Duraisamy Senthil;
Devi, Palanisamy Bruntha;
Sathyabama, Sathyaseelan;
Priyadarisini, Venkatesan Brindha.
(2011)
Assessment of resistomycin, as an anticancer compound isolated and characterized from Streptomyces aurantiacus AAA5.
Journal of Microbiology.
volum 49 (6).
Vitenskapelig artikkel
-
Bruheim, Per.
(2010)
Gjær som pasienter.
Gemini.
volum 4.
Populærvitenskapelig artikkel
-
Bruheim, Per.
(2010)
Med gjær som kreftpasient.
Forskning.no.
publications.INTERVJUSKRIFTL
-
Mørkved, Eva Henmo;
Andreassen, Trygve;
Fröhlich, Roland;
Mo, Frode;
Bruheim, Per.
(2010)
Unsymmetrical zinc azaphthalocyanines, peripherally substituted with thiophen-2-yl and 2-functionalized phenoxy groups.
Polyhedron.
volum 29 (17).
Vitenskapelig artikkel
-
Netzer, Roman;
Stafsnes, Marit Hallvardsdotter;
Andreassen, Trygve;
Goksøyr, Audun;
Bruheim, Per;
Brautaset, Trygve.
(2010)
Biosynthetic Pathway for g-Cyclic Sarcinaxanthin in Micrococcus luteus: Heterologous Expression and Evidence for Diverse and Multiple Catalytic Functions of C50 Carotenoid Cyclases.
Journal of Bacteriology.
volum 192 (21).
Vitenskapelig artikkel
-
Nieselt, Kay;
Battke, Florian;
Herbig, Alexander;
Bruheim, Per;
Wentzel, Alexander;
Jakobsen, Øyvind Mejdell;
Sletta, Håvard;
Alam, Mohammad T.;
Merlo, Maria E.;
Moore, Jonathan;
Omara, Walid A.M.;
Morrissey, Edward R.;
Juarez-Hermosillo, Miguel A.;
Rodríguez-García, Antonio;
Nentwich, Merle;
Thomas, Louise;
Iqbal, Mudassar;
Legaie, Roxane;
Gaze, William H.;
Challis, Gregory L.;
Jansen, Ritsert C.;
Dijkhuizen, Lubbert;
Rand, David A.;
Wild, David L.;
Bonin, Michael;
Reuther, Jens;
Wohlleben, Wolfgang;
Smith, Margaret C.M.;
Burroughs, Nigel J.;
Martín, Juan F.;
Hodgson, David A.;
Takano, Eriko;
Breitling, Rainer;
Ellingsen, Trond Erling;
Wellington, Elisabeth M.H..
(2010)
The dynamic architecture of the metabolic switch in Streptomyces coelicolor.
BMC Genomics.
volum 11.
Vitenskapelig artikkel
-
Stafsnes, Marit Hallvardsdotter;
Josefsen, Kjell D.;
Kildahl-Andersen, Geir;
Valla, Svein;
Ellingsen, Trond E.;
Bruheim, Per.
(2010)
Isolation and Characterization of Marine Pigmented Bacteria from Norwegian Coastal Waters and Screening for Carotenoids with UVA-Blue Light Absorbing Properties.
Journal of Microbiology.
volum 48 (1).
Vitenskapelig artikkel
-
Volkova, Yulia A.;
Averina, Elena B.;
Grishin, Yuri K.;
Bruheim, Per;
Kuznetsova, Tamara S.;
Zefirov, Nikolai S..
(2010)
Unexpected Heterocyclization of Electrophilic Alkenes by Tetranitromethane in the Presence of Triethylamine. Synthesis of 3-Nitroisoxazoles.
Journal of Organic Chemistry.
volum 75 (9).
Vitenskapelig artikkel
-
Jørgensen, Hanne;
Degnes, Kristin;
Sletta, Håvard;
Fjærvik, Espen;
Dikiy, Alexander;
Dikiy, Alexander;
Herfindal, Lars;
Bruheim, Per;
Klinkenberg, Geir;
Bredholt, Harald;
Nygård, Gyrid;
Doskeland, Stein Ove;
Ellingsen, Trond E.;
Zotchev, Sergey B..
(2009)
Biosynthesis of Macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.
Chemistry and Biology.
volum 16 (10).
Vitenskapelig artikkel
-
Bruheim, Per;
Sletta, Håvard;
Zahlsen, Kolbjørn;
Bathen, Tone Frost;
Gribbestad, Ingrid S.
(2009)
metabolomics - et spennende verktøy i medisinsk og biologisk forskning.
NBS-nytt.
volum 1.
Populærvitenskapelig artikkel
-
Jørgensen, Hanne;
Fjærvik, Espen;
Hakvåg, Sigrid;
Bruheim, Per;
Bredholt, Harald;
Klinkenberg, Geir;
Ellingsen, Trond Erling;
Zotchev, Sergey.
(2009)
Candicidin Biosynthesis Gene Cluster Is Widely Distributed among Streptomyces spp. Isolated from the Sediments and the Neuston Layer of the Trondheim Fjord, Norway.
Applied and Environmental Microbiology.
volum 75 (10).
Vitenskapelig artikkel
-
Mørkved, Eva Henmo;
Andreassen, Trygve;
Bruheim, Per.
(2009)
Zinc azaphthalocyanines with pyridin-3-yloxy peripheral substituents.
Polyhedron.
volum 28 (13).
Vitenskapelig artikkel
-
Stockmann, Vegar;
Bakke, Jan Magnus;
Bruheim, Per;
Fiksdahl, Anne.
(2009)
Formation of new 4-isocyanobut-2-enenitriles by thermal ring cleavage of 3-pyridyl azides.
Tetrahedron.
volum 65 (18).
Vitenskapelig artikkel
-
Fuglseth, Erik;
Sundby, Eirik;
Bruheim, Per;
Hoff, Bård Helge.
(2008)
Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols.
Tetrahedron: asymmetry.
volum 19 (16).
Vitenskapelig artikkel
-
Fuglseth, Erik;
Sundby, Eirik;
Bruheim, Per;
Hoff, Bård Helge.
(2008)
Asymmetric reduction using (R)-MeCBS and determination of absolute configuration of para-substituted 2-fluoroarylethanols.
Tetrahedron: asymmetry.
volum 19.
Vitenskapelig artikkel
-
Simon, Sebastien Charles;
Nordgård, Erland;
Bruheim, Per;
Sjøblom, Johan.
(2008)
Determination of C-80 tetra-acid content in calcium naphthenate deposits.
Journal of Chromatography A.
volum 1200.
Vitenskapelig artikkel
-
Villas-Boas, Silas G.;
Bruheim, Per.
(2007)
Cold glycerol–saline: The promising quenching solution for accurate intracellular metabolite analysis of microbial cells.
Analytical Biochemistry.
volum 370.
Vitenskapelig artikkel
-
Villas-Boas, Silas G.;
Bruheim, Per.
(2007)
The potential of metabolomics tools in bioremediation studies.
Omics.
volum 11 (3).
Vitenskapelig oversiktsartikkel/review
-
Holtan, Synnøve;
Bruheim, Per;
Skjåk-Bræk, Gudmund.
(2006)
Mode of action and subsite studies of the guluronan block forming mannuronan C-5 epimerases AlgE1 and AlgE6.
Biochemical Journal.
volum 395.
Vitenskapelig artikkel
-
Otterlei, Marit;
Bruheim, Per;
Ahn, Byungchan;
Bussen, Wendy;
Karmakar, Parimal;
Baynton, Kathy;
Bohr, Vilhelm A..
(2006)
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of Cell Science.
volum 119 (24).
Vitenskapelig artikkel
-
Sletta, Håvard;
Bruheim, Per;
Borgos, Sven Even F.;
Sekurova, Olga;
Grasdalen, Hans;
Aune, Randi;
Zotchev, Sergey;
Ellingsen, Trond Erling.
(2005)
Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.
Antimicrobial Agents and Chemotherapy.
volum 49 (11).
Vitenskapelig artikkel
-
Bruheim, Per;
Borgos, Sven Even F.;
Tsan, Pascale;
Sletta, Håvard;
Ellingsen, Trond Erling;
Lancelin, Jean-Marc;
Zotchev, Sergey.
(2004)
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
Antimicrobial Agents and Chemotherapy.
volum 48 (11).
Vitenskapelig artikkel
-
Butler, M.;
Takano, E.;
Bruheim, Per;
Jovetic, Srdjan;
Marinelli, Flavia;
Bibb, Mervyn J..
(2003)
Deletion of scbA enhances antibiotic production in Streptomyces lividans.
Applied Microbiology and Biotechnology.
volum 61.
Vitenskapelig artikkel
-
Gunnarsson, Nina;
Bruheim, Per;
Nielsen, Jens.
(2003)
Production of the glycopeptide antibiotic A40926 by Nonomuraea sp. ATCC 39727: influence of medium composition in batch fermentation.
Journal of Industrial Microbiology & Biotechnology.
volum 30.
Vitenskapelig artikkel
-
Robin, J.;
Bruheim, Per;
Nielsen, M.L.;
Noorman, H.;
Nielsen, Jens.
(2003)
Continuous cultivations of a Pencillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetyoxycephalosporanic acid and byproduct formations.
Biotechnology and Bioengineering.
volum 83 (3).
Vitenskapelig artikkel
-
Brautaset, Trygve;
Bruheim, Per;
Sletta, Håvard;
Hagen, Lars;
Ellingsen, Trond E.;
Strøm, Arne Reidar;
Valla, Svein;
Zotchev, Sergey.
(2002)
Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455.
Chemistry and Biology.
volum 9.
Vitenskapelig artikkel
-
Bredholt, Harald;
Bruheim, Per;
Potocky, Martin;
Eimhjellen, Kjell.
(2002)
Hydrophobicity development, alkane oxidation, and crude-oil emulsification in a Rhodococcus species.
Canadian Journal of Microbiology (print).
volum 48.
Vitenskapelig artikkel
-
Bruheim, Per;
Butler, M.;
Ellingsen, Trond E..
(2002)
A theoretical analysis of the biosynthesis of actinorhodin in a hyper-producing Streptomyces lividans strain cultivated on various carbon sources.
Applied Microbiology and Biotechnology.
volum 58.
Vitenskapelig artikkel
-
Bruheim, Per;
Sletta, Håvard;
Bibb, M.J.;
White, J.;
Levine, David William.
(2002)
High-yield actinorhodin production in fed-batch culture by a Streptomyces lividans strain overexpressing the pathway-specific activator gene actII-ORF4.
Journal of Industrial Microbiology & Biotechnology.
volum 28.
Vitenskapelig artikkel
-
Butler, M.;
Bruheim, Per;
Jovetic, Srdjan;
Marinelli, Flavia;
Postma, Pieter W.;
Bibb, Mervyn J..
(2002)
Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans.
Applied and Environmental Microbiology.
volum 68 (10).
Vitenskapelig artikkel
-
Bruheim, Per.
(2000)
Metabolic engineering - fremtidens verktøy for utvikling av industrielle bioteknologiske prosesser?.
NBS-nytt.
Populærvitenskapelig artikkel
-
Bruheim, Per;
Eimhjellen, Kjell.
(2000)
Effects of non-ionic surfactants on the uptake and hydrolysis of fluoresceindiacetate by alkane-oxidizing bacteria.
Canadian Journal of Microbiology (print).
volum 46 (4).
Vitenskapelig artikkel
-
Bruheim, Per;
Bredholt, Harald;
Eimhjellen, Kjell.
(1999)
Effects of surfactant mixtures, including Corexit 9527, on bacterial oxidation of acetate and alkanes in crude oil.
Applied and Environmental Microbiology.
volum 65 (4).
Vitenskapelig artikkel
-
Bredholt, Harald;
Josefsen, Kjell;
Vatland, Arild;
Bruheim, Per;
Eimhjellen, Kjell.
(1998)
Emulsification of crude oil by an alkane-oxidizing Rhodococcus species isolated from seawater.
Canadian Journal of Microbiology (print).
volum 44.
Vitenskapelig artikkel
-
Bruheim, Per;
Eimhjellen, Kjell.
(1998)
Chemically emulsified crude oil as substrate for bacterial oxdidation : differences in species response.
Canadian Journal of Microbiology (print).
volum 44/1998.
Vitenskapelig artikkel
-
Bruheim, Per;
Bredholt, Harald;
Eimhjellen, Kjell.
(1997)
Bacterial degradation of emulsified crude oil and the effect of various surfactants.
Canadian Journal of Microbiology (print).
volum 43.
Vitenskapelig artikkel
-
Thu, Beate;
Bruheim, Per;
Espevik, Terje;
Smidsrød, Olav;
Soon-Shiong, P.;
Skjåk-Bræk, Gudmund.
(1996)
Alginate polycation microcapsules. I, Interaction between alginate and polycation.
Biomaterials.
volum 17.
Vitenskapelig artikkel
-
Thu, Beate;
Bruheim, Per;
Espevik, Terje;
Smidsrød, Olav;
Soon-Shiong, Patrick;
Skjåk-Bræk, Gudmund.
(1996)
Alginate polycation microcapsules. II, Some functional properties.
Biomaterials.
volum 17.
Vitenskapelig artikkel
-
Stokke, Bjørn Torger;
Smidsrød, Olav;
Bruheim, Per;
Skjåk-Bræk, Gudmund.
(1991)
Distribution of uronate residues in alginate chains in relation to alginate gelling properties.
Macromolecules.
volum 24.
Vitenskapelig artikkel
Del av bok/rapport
-
Kvitvang, Hans Fredrik Nyvold;
Kristiansen, Kåre Andre;
Lien, Stina Katrine;
Bruheim, Per.
(2014)
Quantitative Analysis of Amino and Organic Acids by Methyl Chloroformate Derivatization and GC-MS/MS Analysis.
Mass Spectrometry in Metabolomics: Methods and Protocols.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Stafsnes, Marit Hallvardsd;
Bruheim, Per.
(2013)
Pigmented Marine Heterotrophic Bacteria: Occurrence, Diversity, and Characterization of Pigmentation.
Marine Biomaterials: Characterization, Isolation and Applications.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Almaas, Eivind;
Bruheim, Per;
Lale, Rahmi;
Valla, Svein.
(2012)
Dynamics and robustness of metabolic networks: A systems biology review of Escherichia coli metabolism.
Systems Microbiology - Current Topics and Applications.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Wojtowicz, Petr;
Zrostlíková, Jitka;
Šťastná, Veronika;
Dostálová, Eva;
Zídková, Lenka;
Bruheim, Per;
Adam, Tomáš.
(2012)
Comprehensive Two-Dimensional Gas Chromatography Coupled to Time-of-Flight Mass Spectrometry in Human Metabolomics.
Gas Chromatography – Biochemicals, Narcotics and Essential Oils.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
Rapport
-
Pedersen, Eilif;
Eitungjerde, Sara;
André, Thea Harnes;
Bruheim, Per;
Grønflaten, Lars Trovatten;
Gundersen, Ingeborg Nævdal;
Hartnik, Lukas;
Kraemer, Frank Alexander;
Sigurjónsson, Jóhannes B.;
Torvatn, Tim Kristian Andreas.
(2021)
Fremtidens teknologistudier (FTS), grupperapport: A3 - 5-årig master.
2021.
Rapport
-
Johansen, Finn-Eirik;
Brautaset, Trygve;
Aune, Marie Hjelmseth;
Patriksson, Alexandra;
Falkenberg, Liv Eggset;
Kleppe, Rune;
Dick, Gunnar;
Strand, Berit Løkensgard;
Eijsink, Vincent;
Røyne, Anja;
Goksøyr, Anders;
Svendsen, John Sigurd Mjøen;
Fyhn, Marianne;
Vik, Jon Olav;
Wentzel, Alexander;
Aksnes, Astrid;
Bruheim, Per;
Carlsen, Sven Magnus;
Åm, Heidrun.
(2018)
Centre for Digital Life Norway - Annual report 2017.
2018.
Rapport
Formidling
2020
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Vitenskapelig foredragEide, Marta; Goksøyr, Anders; Yadetie, Fekadu; Gilabert, Alejandra; Bartosova, Zdenka; Frøysa, Håvard G; Fallahi, Shirin; Zhang, Xiaokang; Blaser, Nello; Jonassen, Inge; Bruheim, Per; Alendal, Guttorm; Brun, Morten; Porte, Cinta; Karlsen, Odd Andre. (2020) A multi-omics approach to study Ppar-mediated regulation of lipid metabolism in Atlantic cod (Gadus morhua). 8th Norwegian Environemntal Toxicology Symposium (NETS) 2020 ; Digital. 2020-11-04 - 2020-11-05.
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Vitenskapelig foredragNilsen, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas; Nygård, Ottar; Skorve, Jon; Madsen, Lise; Dankel, Simon N; Berge, Rolf Kristian. (2020) Low 3-hydroxyisobutyrate (3-HIB) and high methylmalonic acid (MMA) levels in plasma reflect increased hepatic fatty acid oxidation. 11th World Congress on Targeting Mitochondria 2020 . World Mitochondria Society; 2020-10-28 - 2020-10-30.
2019
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Vitenskapelig foredragAasen, Inga Marie; Bartosova, Zdenka; Haslene-Hox, Hanne; Heggeset, Tonje Marita Bjerkan; Stafsnes, Marit Hallvardsdotter; Bruheim, Per; Ertesvåg, Helga. (2019) Elucidating lipid accumulation and DHA synthesis in Aurantiochytrium sp. strain T66 using -omics technologies. NFM Meeting, Applied and Environmental Microbiology . Norsk forening for Mikrobiologi; Trondheim. 2019-06-11 - 2019-06-12.
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Vitenskapelig foredragAasen, Inga Marie; Haslene-Hox, Hanne; Ertesvåg, Helga; Heggeset, Tonje Marita Bjerkan; Bruheim, Per. (2019) Fatty acid synthesis in Aurantiochytrium sp, revealed by analyses of growth and production kinetics and global proteomes. First International Conference on Labyrinthulean Protists (ICoLP) ; Kobe. 2019-08-28 - 2019-08-30.
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Vitenskapelig foredragAasen, Inga Marie; Haslene-Hox, Hanne; Stafsnes, Marit Hallvardsdotter; Heggeset, Tonje Marita Bjerkan; Bruheim, Per. (2019) Lipid accumulation and DHA synthesis in Aurantiochytrium sp, elucidated by transcriptome, proteome and metabolome analyses. BIOPROSP_19 ; Tromsø. 2019-02-25 - 2019-02-27.
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PosterBartosova, Zdenka; Gonzalez, Susana Villa; Bruheim, Per. (2019) High-throughput method for lipidomic analysis and semi-quantification of lipid classes. NBS Kontaktmøte 2019 . Norsk Biokjemisk Selskap; Røros. 2019-01-24 - 2019-01-27.
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PosterBartosova, Zdenka; Stafsnes, Marit Hallvardsdotter; Voigt, Andre; Bruheim, Per. (2019) Supercritical fluid chromatography with mass spectrometry: A versatile tool for lipid profiling and lipid class quantitation. DigitalLife 2019 . Digital Life Norway; Tromsø. 2019-09-05 - 2019-09-06.
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PosterErtesvåg, Helga; Haslene-Hox, Hanne; Aasen, Inga Marie; Almaas, Eivind; Bartosova, Zdenka; Heggeset, Tonje Marita Bjerkan; Le, Simone Balzer; Rau, E-Ming; Stafsnes, Marit Hallvardsdotter; Voigt, Andre; Bruheim, Per. (2019) Industrial microbiology – 'omics methods and modelling as tools for process optimization. DigitalLife 2019 . Digital Life Norway; Tromsø. 2019-09-05 - 2019-09-06.
-
PosterFuchino, Katsuya; Bruheim, Per. (2019) Improved acetaldehyde production by engineered Zymomonas mobilis strains. EMBL new approaches and concepts in microbiology ; 2019-07-10 - 2019-07-13.
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PosterKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2019) Carbon distribution within metabolic pathways during antibiotic production by Streptomyces superhost strains. 3rd Open Conference of Functional Metagenomics International FUNCTIONAL METAGENOMICS 2019 ; Trondheim. 2019-06-16 - 2019-06-19.
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Faglig foredragKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2019) Deciphering the carbon distribution in metabolic pathways during antibiotic production by Streptomyces superhost strains using 13C-isotope-labeling experiments. Minisymposia at NBS Winter meeting 2019 ; Røros. 2019-01-24 - 2019-01-26.
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PosterKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2019) Studying the metabolism of Streptomyces coelicolor during antibiotic production in submerged batch fermentations. 8th Congress of European Microbiologists - FEMS2019 ; Glasgow, Scotland. 2019-07-07 - 2019-07-11.
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PosterKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2019) Studying the metabolism of Streptomyces coelicolor during antibiotic production using 13C-isotope-labeling experiments. 3rd annual Biotechnology Research and Innovation conference . NTNU, UiO and UiB; Tromsø. 2019-09-04 - 2019-09-05.
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PosterRøst, Lisa Marie; Løkken, Erle Gustavsen; Otterlei, Marit; Bruheim, Per. (2019) Glioblastoma cells respond to hypoxia by increased cell growth and altered TCA-cycle progression. NBS Vintermøte . Norsk Biokjemisk Selskap Trondheim; Røros. 2019-01-24 - 2019-01-27.
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PosterSchulz, Christian; Karlsen, Emil; Kumar, Kanhaiya; Bartosova, Zdenka; Schmid, Jochen; Bruheim, Per; Almaas, Eivind. (2019) Measuring Biomass Composition for Modelling. DLN anual conference ; 2019-09-05 - 2019-09-06.
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PosterStafsnes, Marit Hallvardsdotter; Bartosova, Zdenka; Bruheim, Per. (2019) Metabolomics and fluxomics - essential approaches in optimization of bioprocesses. Digital Life Norway 2019 . DLN; Tromsø. 2019-09-05 - 2019-09-06.
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PosterThorfinnsdottir, Lilja Brekke; Bruheim, Per. (2019) Antibiotic tolerance vs persistence: How to assay and distinguish the terms. Norwegian Biochemical Society 55th Contact Meeting . Norwegian Biochemical Society; Røros. 2019-01-24 - 2019-01-27.
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Vitenskapelig foredragThorfinnsdottir, Lilja Brekke; Bruheim, Per. (2019) Development of an unbiased method to study persistent bacteria. NFM meeting . Norwegian Society for Microbiology; Trondheim. 2019-06-11 - 2019-06-12.
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Vitenskapelig foredragWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre; Borgos, Sven Even F.; Kumelj, Tjasa; Kumar, Kanhaiya; Bruheim, Per; Almaas, Eivind; Liles, Mark R.; Sandoval, Megan; Waits, Damien S.; Mead, David A.; Medema, Marnix H.; Navarro Munoz, Jorge; Fernandez-Guerra, Antonio; van Dissel, Dino; Hulst, Mandy; Chao, Du; Van Wezel, Gilles P.; Wang, Hao; Kerkhoven, Eduard; Salehzadeh-Yazdi, Ali; Wolkenhauer, Olaf; Nieselt, Kay; Iftime, Dumitrita; Bera, Agnieszka; Hinder, Markus; Stegmann, Evi; Wohlleben, Wolfgang; Ellingsen, Trond Erling; Sletta, Håvard. (2019) Expanding the (meta)genomics toolbox for the discovery and production of novel natural products from microbial resources. 2nd Synthetic Biology for Natural Products Conference . Fusion Conferences; Puerto Vallarta. 2019-06-02 - 2019-06-05.
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Vitenskapelig foredragWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre; Borgos, Sven Even F.; Kumelj, Tjasa; Kumar, Kanhaiya; Bruheim, Per; Almaas, Eivind; Liles, Mark R.; Sandoval, Megan; Waits, Damien S.; Mead, David A.; Medema, Marnix H.; Navarro Munoz, Jorge; Fernandez-Guerra, Antonio; van Dissel, Dino; Hulst, Mandy; Du, Chao; Van Wezel, Gilles P.; Wang, Hao; Kerkhoven, Eduard; Salehzadeh-Yazdi, Ali; Wolkenhauer, Olaf; Nieselt, Kay; Iftime, Dumitrita; Bera, Agnieszka; Hinder, Markus; Stegmann, Evi; Wohlleben, Wolfgang; Ellingsen, Trond Erling; Sletta, Håvard. (2019) Expanding the (meta)genomics toolbox for the discovery and production of novel natural products from microbial resources. Functional Metageomics 2019 . SINTEF/NTNU; Trondheim. 2019-06-16 - 2019-09-19.
2018
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PosterBartosova, Zdenka; Stafsnes, Marit Hallvardsdotter; Gjuvsland, Arne Bjørke; Harvey, Thomas Nelson; Nanton, Dominic; Sandve, Simen Rød; Torgersen, Jacob Seilø; Vik, Jon Olav; Bruheim, Per. (2018) Mass spectrometry based profiling of the salmon lipidome. DigitalLife 2018 . Centre for Digital Life Norway; Bergen. 2018-03-20 - 2018-03-21.
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PosterFuchino, Katsuya; Bruheim, Per. (2018) A novel bacterial system with integrated micro-bubble distillation for the production of acetaldehyde. Digital life 2018 annual conference . Digital life Norway; Bergen. 2018-03-20 - 2018-03-21.
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PosterKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2018) Intracellular metabolite profiling of Streptomyces coelicolor A3(2) during antibiotic production in nutrient stressed batch fermentation. Digital Life Workshop ; Bergen. 2018-03-20 - 2018-03-21.
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Faglig foredragKumar, Kanhaiya; Wentzel, Alexander; Bruheim, Per. (2018) Intracellular metabolite profiling of Streptomyces coelicolor A3(2) in nutrient stressed batch fermentation for antibiotic production. European Congress of Biotechnology 2018 . European Federation of Biotechnology; Geneva. 2018-07-01 - 2018-07-04.
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PosterOlaisen, Camilla; Røst, Lisa Marie; Nedal, Aina; Petrovic, Voin; Kvitvang, Hans Fredrik Nyvold; Bruheim, Per; Otterlei, Marit. (2018) Proliferating Cell Nuclear Antigen (PCNA) has a Central Role in Regulation of the Glycolysis in Haematological Cancer Cells. Metabolism and Cancer . American Association of Cancer Research; Marriott New York Brooklyn Bridge. 2018-09-28 - 2018-10-01.
2017
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PosterBösl, Korbinian; Røst, Lisa Marie; Giambelluca, Miriam; Bruheim, Per; Kandasamy, Richard Kumaran. (2017) Integrative analysis of the inflammatory signalling kinome landscape. Digital Life 2017 . Centre for Digital Life Norway; Oslo. 2017-03-20 - 2017-03-21.
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Faglig foredragWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre; Kumelj, Tjasa; Bruheim, Per; Almaas, Eivind; Liles, Mark R.; Sandoval, Megan; Waits, Damien; ERASysAPP SYSTERACT cons., The; Ellingsen, Trond Erling; Sletta, Håvard. (2017) New bioactive compounds from environmental microbial resources by an integrated functional (meta)genomics approach. Synthetic Biology of Natural Products . FUSION conferences; Hotel Fiesta Americana Condesa, Cancun. 2017-03-05 - 2017-03-08.
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Faglig foredragWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre; Kumelj, Tjasa; Bruheim, Per; Almaas, Eivind; Liles, Mark R.; Sandoval, Megan; Waits, Damien; ERASysAPP SYSTERACT cons., The; Ellingsen, Trond Erling; Sletta, Håvard. (2017) New bioactive compounds from environmental microbial resources by an integrated functional (meta)genomics approach. BioProsp 2017, the 8th International Conference on Marine Biotechnology . UiT; UiT, Tromsø. 2017-03-08 - 2017-03-10.
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Faglig foredragWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre; Kumelj, Tjasa; Bruheim, Per; Almaas, Eivind; Liles, Mark R.; Sandoval, Megan; Waits, Damien; ERASysAPP SYSTERACT cons., The; Ellingsen, Trond Erling; Sletta, Håvard. (2017) New bioactive compounds from environmental microbial resources by an integrated functional (meta)genomics approach. Centre for Digital Life Norway - Annual conference . Centre for Digital Life Norway; Hotel Bristol, Oslo. 2017-03-20 - 2017-03-21.
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Faglig foredragWentzel, Alexander; Lewin, Anna; Nordborg, Anna; Nguyen, Giang-Son; Degnes, Kristin Fløgstad; Sulheim, Snorre; Kumelj, Tjasa; Bruheim, Per; Almaas, Eivind; Liles, Mark R.; Sandoval, Megan; Waits, Damien; ERASysAPP SYSTERACT cons., The; Ellingsen, Trond Erling; Sletta, Håvard. (2017) New bioactive compounds from environmental microbial resources by an integrated functional (meta)genomics approach. Meeting with the ReDig project . SINTEF, RG Biotechnology; SINTEF, RG Biotechnology. 2017-09-19 - 2017-09-19.
2016
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PosterBösl, Korbinian; Røst, Lisa Marie; Giambelluca, Miriam; Bruheim, Per; Kandasamy, Richard Kumaran. (2016) Integrative analysis of the inflammatory signalling kinome landscape. National Graduate School in Infection Biology and and Antimicrobial Kick-Off meeting . National Graduate School in Infection Biology and and Antimi; Oslo. 2016-11-14 - 2016-11-15.
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PosterHeggeset, Tonje Marita Bjerkan; Lewin, Anna; Nguyen, Giang-Son; Nordborg, Anna; Degnes, Kristin Fløgstad; Sletta, Håvard; Zahlsen, Kolbjørn; Ellingsen, Trond Erling; Bruheim, Per; Almaas, Eivind; Wentzel, Alexander. (2016) INBioPharm - Integrated Novel Natural Product Discovery and Production Platform for Accelerated Biopharmaceutical Innovation from Microbial Biodiversity. Functional Metagenomics 2016 . SINTEF; Jægtvolden Fjordhotell, Inderøy. 2016-09-25 - 2016-09-28.
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PosterRøst, Lisa Marie; Olaisen, Camilla; Petrovic, Voin; Otterlei, Marit; Bruheim, Per. (2016) Blocking the Stress-specific APIM-PCNA Interaction in Multiple Myeloma Cells Cause Significant Changes in Central Carbon Metabolism. ISCaM 2016: Metabolic Networks in Cancer . International Society of Cancer Metabolism; Brussel. 2016-10-26 - 2016-10-29.
2015
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IntervjuBruheim, Per. (2015) Utdanning og forskning innen ølbrygging ved NTNU. NRK P1 Her og Nå [Radio]. 2015-04-17.
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IntervjuBruheim, Per; Vadstein, Olav. (2015) Nå kan du studere ølbrygging på NTNU. Forskning.no [Internett]. 2015-04-10.
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ProgramdeltagelseBruheim, Per; Vadstein, Olav. (2015) Utdanning og forskning innen ølbrygging ved NTNU. NRK1 Scrødingers katt [TV]. 2015-04-10.
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PosterMühlroth, Alice; Bones, Atle M.; Vadstein, Olav; Hohmann-Marriott, Martin; El-Assimi, Aimen; Røkke, Gunvor; Bruheim, Per; Winge, Per; Despres, Julie. (2015) Investigation of transcriptional regulation in microalgae Nannochloropsis oceanica CCMP1779 under induced TAG accumulation by phosphate deficiency. EPC6 european phylogeny congress 6 ; 2015-08-23 - 2015-08-28.
2014
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Vitenskapelig foredragStafsnes, Marit Hallvardsdotter; Bruheim, Per. (2014) Deep Phenotyping using Mass Spectrometry based Metabolomics and Fluxomics. NTNU - Bioinformatics Network Seminar 2014 . NTNU; Trondheim. 2014-12-08 - 2014-12-08.
2012
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Vitenskapelig foredragBruheim, Per. (2012) Insights into bacterial metabolism by using mass spectrometric metabolomics tools. NBS Avdeling Trondheim "Oppdalsmøte" ; Storlien. 2012-04-16 - 2012-04-17.
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Vitenskapelig foredragBruheim, Per. (2012) Quantitative metabolomics for analysis of biological extracts. 20. Norske Symposium i Kromatografi ; Sandefjord. 2012-01-08 - 2012-01-10.
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PosterJanecková, Hana; Friedecky, D.; Wojtowicz, P.; Hron, Karel; Brunsvik, A.; Correa, E.; Micova, K.; Najdekr, L.; Bruheim, Per; Goodacre, R.; Adam, T.. (2012) Untargeted metabolomics for diagnosing inherited metabolic diseases. 27th International Symposium on MicroScale Bioseparations and Analyses ; Geneva. 2012-02-12 - 2012-02-15.
2011
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Vitenskapelig foredragBruheim, Per. (2011) A new GC-MS/MS method for quantitative Metabolite Profilng of amino and carboxyilic acid containing metabolites. The Norwegian Biochemical Society 47th Contact Meeting ; Tromsø. 2011-02-03 - 2011-02-06.
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PosterKvitvang, Hans Fredrik Nyvold; Andreassen, Trygve; Adam, Tomas; Villas-Boas, Silas G.; Bruheim, Per. (2011) High sensitive GC-MS/MS method for absolute quantitation of amino and non-amino organic acids. Norsk Selskap for Massespektrometri (NSMS) ; 2011-01-23 - 2011-01-26.
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PosterLien, Stina Katrine; Sletta, Håvard; Vernstad, Kai; Valla, Svein; Bruheim, Per. (2011) Mass spectrometry based Metabolome analysis of the alginate producing bacterium Pseudomonas fluorescens. Det 14. Norske seminar i massespektrometri . Norsk selskap for massespektrometri (NSMS); Hafjell. 2011-01-23 - 2011-01-26.
2010
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IntervjuBruheim, Per; Andersen, Steinar Q.. (2010) Her utvikles kreftvaksine ved hjelp av bakegjær. VG [Avis]. 2010-12-15.
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PosterFriedecky, D.; Krätschmerova, H.; Micova, K.; Wojtowicz, P.; Adamova, K.; Brunsvik, A.; Bruheim, Per; Adam, T.. (2010) Diagnosing of inherited metabolic disorders by LC-QTOF analysis of cultured skin fibroblasts. Advances in Metabolite Profiling ; Firenze. 2010-11-09 - 2010-11-10.
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Vitenskapelig foredragWentzel, Alexander; Øverby, Anders; Hoel, Sunniva; Bruheim, Per; Sletta, Håvard; Ellingsen, Trond E.. (2010) High reproducibility system for submerged batch cultivations of Streptomyces coelicolor as the basis for systems biology research in Streptomycetes. 11th International Symposium on the Genetics of Industrial Microorganisms ; Melbourne. 2010-06-28 - 2010-07-01.
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Vitenskapelig foredragØvrehus, Marius Altern; Bruheim, Per; Zahlsen, Kolbjørn; Hallan, Stein. (2010) Nye biomarkører for nyresvikt. Vårmøtet til Norsk Nyremedisinsk Forening . Norsk Nyremedisinsk Forening; Arendal. 2010-06-09 - 2010-06-11.
2009
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PosterJørgensen, Hanne; Degnes, Kristin F.; Sletta, Håvard; Fjærvik, Espen; Dikiy, Alexander; Herfindal, Lars; Bruheim, Per; Klinkenberg, Geir; Bredholt, Harald; Nygård, Gyrid; Døskeland, Stein O.; Ellingsen, Trond Erling; Zotchev, Sergey. (2009) The biosynthesis of macrolactam BE-14106: a new way of generating an aminoacyl starter unit. The Fifteenth International Symposium on the Biology of Actinomycetes 2009 (ISBA15) ; 2009-08-20 - 2009-08-25.
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Vitenskapelig foredragJørgensen, Hanne; Engelhardt, Kerstin; Sletta, Håvard; Fjærvik, Espen; Klinkenberg, Geir; Degnes, Kristin F.; Ian, Elena; Bredholt, Harald; Kemmler, M.; Terekhova, Larissa P.; Galatenko, Olga A.; Dikiy, Alexander; Bruheim, Per; Ellingsen, Trond Erling; Zotchev, Sergey. (2009) Streptomycetes and other actinobacteria from the Trondheim fjord (Norway): diversity, secondary metabolites, and genes for their biosynthesis. Symposium on the Biology of Streptomyces ; Muenster. 2009-10-07 - 2009-10-11.
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Vitenskapelig foredragZotchev, Sergey; Jørgensen, Hanne; Degnes, Kristin F.; Sletta, Håvard; Fjærvik, Espen; Dikiy, Alexander; Herfindal, L.; Bruheim, Per; Klinkenberg, Geir; Bredholt, Harald; Nygård, G.; Døskeland, Stein O.; Ellingsen, Trond Erling. (2009) SMALL-RING MACROLACTAMS WITH ACYL SIDE CHAIN: NEW INSIGHTS INTO THE BIOSYNTHESIS AND ITS EVOLUTION. 15th International Symposium on the Biology of Actinomycetes ; Shanghai. 2009-08-20 - 2009-08-25.
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PosterBruheim, Per; Sletta, Håvard; Klinkenberg, Geir; Ellingsen, Trond Erling; Krokan, Hans Einar; Otterlei, Marit. (2009) Systems biology and high resolution genome-wide phenotyping of yeast used for identification of cellular and molecular effects of DNA damaging agents. 3rd US-EU Workshop "Systems level understanding of DNA damage responses" ; Egmond aan Zee. 2009-03-30 - 2009-04-01.
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PosterMærk, Mali; Lien, Stina Katrine; Ertesvåg, Helga; Bruheim, Per; Valla, Svein. (2009) An Entner-Doudoroff pathway mutation in Pseudomonas fluorescens causes cell death during alginate production. The Norwegian Biochemical Society 45th Contact Meeting . Norsk Biokjemisk Selskap; Røros. 2009-01-29 - 2009-02-01.
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Vitenskapelig foredragWentzel, Alexander; Jakobsen, Øyvind M.; Øverby, Anders; Hoel, Sunniva; Bruheim, Per; Sletta, Håvard; Strøm, Arne Reidar; Ellingsen, Trond Erling. (2009) A systems biology approach towards understanding metabolic switching from primary to secondary metabolism in Streptomyces coelicolor. NBS Vintermøte . Norsk Biokjemisk Selskap; Røros. 2009-01-29 - 2009-02-01.
2008
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PosterStavne, Tonje; Mærk, Mali; Bruheim, Per; Engelhardt, Kerstin. (2008) Mikrobiell og industriell bioteknologi. Researchers' Night Trondheim . Norges Forskningsråd; Trondheim. 2008-09-26 - 2008-09-26.
2007
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Vitenskapelig foredragBruheim, Per. (2007) Microbial metabolomics. AgResearch ; Grasslands and Massey Univerisity, Palmerston North. 2007-06-01 - 2007-06-01.
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PosterJørgensen, Hanne; Fjærvik, Espen; Hakvåg, Sigrid; Bruheim, Per; Bredholt, Harald; Klinkenberg, Geir; Zotchev, Sergey. (2007) Spread of antibiotic biosynthesis genes among streptomycetes in the Trondheim fjord possibly involves mobile genetic elements. The Fourteenth International Symposium on the Biology of Actinomycetes 2007 (ISBA14) ; Newcastle. 2007-08-26 - 2007-08-30.
2004
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Vitenskapelig foredragBorgos, Sven Even F.; Bruheim, Per; Sletta, Håvard; Sekurova, Olga; Ellingsen, Trond Erling; Zotchev, Sergey. (2004) Generation of novel antibiotics via manipulation of the nystatin biosynthetic gene cluster in the bacterium Streptomyces noursei. 2nd International Conference "Genomics, Proteomics and Bioinformatics for Medicine" ; Moskva. 2004-07-14 - 2004-07-19.
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PosterBruheim, Per; Borgos, Sven Even F.; Sletta, Håvard; Tsan, Pascale; Ellingsen, Trond Erling; Lancelin, Jean-Marc; Zotchev, Sergey. (2004) Nystatin biosynthesis: natural and engineered diversity of polyene macrolides produced by Streptomyces noursei. Genetics and Molecular Biology of Industrial Microorganisms conference ; San Diego. 2004-11-14 - 2004-11-18.
2003
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PosterBrautaset, Trygve; Bruheim, Per; Sekurova, Olga; Borgos, Sven Even F.; Sletta, Håvard; Ellingsen, Trond E.; Zotchev, Sergey. (2003) Nystatin biosynthesis in Streptomyces noursei: lessons learned from the gene knockout experiments. Biology of Streptomycetes . [Mangler data]; Münster, Germany. 2003-03-03.
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Vitenskapelig foredragOtterlei, Marit; Bruheim, Per; Byungchan, Ahn; Baynton, Kathy; Opresko, Patricia; Seeberg, E.; Sung, Patrick; Bohr, Vilhelm. (2003) DNA damage causing replication arrest leads to a relocation of WRN hekicase to complexes containing proteins from the RAD52 epistasis group: RAD52, RAD51, RAD54 and RAD54B. Possible role for WRN in regulation of HR. International Workshop on Werner Syndrome . [Mangler data]; Lansdowne. 2003-05-31.
2002
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Vitenskapelig foredragBrautaset, Trygve; Bruheim, Per; Sekurova, Olga; Sletta, Håvard; Ellingsen, Trond E.; Strøm, Arne Reidar; Valla, Svein; Zotchev, Sergey. (2002) Nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455: mutational analysis, and future perspectives for genetic manipulation. 9th International Symposium on the Genetics of Industrial Microorganisms, . [Mangler data]; Gjeongju, South Korea. 2002-07-05.
2001
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PosterBrautaset, Trygve; Bruheim, Per; Sletta, Håvard; Ellingsen, T.E.; Strøm, Arne Reidar; Valla, Svein; Zotchev, Sergey. (2001) Novel polyene antibiotics via genetic manipulation of the nystatin polyketide synthase. ISBA møte . [Mangler data]; Vancouver. 2001-08-10.
1998
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Vitenskapelig foredragBruheim, Per. (1998) Actinorhodin production by Streptomyces liridans: activation of the biosynthetic pathway related to growth, morphology and medium composition. Biokjemisk kontaktmøte . [Mangler data]; Lillehammer.