Per Arne Aas
Publikasjoner
2023
-
Ravlo, Erlend;
Sousa, Mirta;
Andresen, Lise Lima;
Holberg-Petersen, Mona;
Klundby, Ingvild;
Aas, Per Arne.
(2023)
A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles.
Scientific Reports
Vitenskapelig artikkel
2021
-
Kavli, Bodil Merete;
Iveland, Tobias Solli;
Buchinger, Edith;
Hagen, Lars;
Liabakk, Nina-Beate;
Aas, Per Arne.
(2021)
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Hegre, Siv Anita;
Samdal, Helle;
Klima, Antonin;
Stovner, Endre Bakken;
Nørsett, Kristin Gabestad;
Liabakk, Nina-Beate.
(2021)
Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation.
Scientific Reports
Vitenskapelig artikkel
-
Steen, Kristian Wollen;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Rabe, Renana;
Iveland, Tobias Solli;
Aas, Per Arne.
(2021)
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Journal of Translational Medicine
Vitenskapelig artikkel
2020
-
Ianevski, Aleksandr;
Yao, Rouan;
Fenstad, Mona H.;
Biza, Svetlana;
Zusinaite, Eva;
Reisberg, Tuuli.
(2020)
Potential Antiviral Options against SARS-CoV-2 Infection. Viruses.
Viruses
Vitenskapelig artikkel
-
Yang, Mingyi;
Lin, Xiaolin;
Segers, Filip;
Suganthan, Rajikala;
Hildrestrand, Gunn Annette;
Rinholm, Johanne Egge.
(2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation.
Cell reports
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Biza, Svetlana;
Zusinaite, Eva;
Mannik, Andres;
Kivi, Gaily.
(2020)
Identification and Tracking of Antiviral Drug Combinations.
Viruses
Vitenskapelig artikkel
2019
-
Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Vitenskapelig artikkel
2018
-
Dewan, Alisa Elinsdatter;
Xing, Mengtan;
Lundbæk, Marie Benner;
Gago-Fuentes, Raquel;
Beck, Carole;
Aas, Per Arne.
(2018)
Robust DNA repair in PAXX-deficient mammalian cells.
FEBS Open Bio
Vitenskapelig artikkel
2017
-
Buchinger, Edith;
Wiik, Siv Åshild;
Kusnierczyk, Anna;
Rabe, Renana;
Aas, Per Arne;
Kavli, Bodil Merete.
(2017)
Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2.
Biomolecular NMR Assignments
Vitenskapelig artikkel
2015
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
-
Mjelle, Robin;
Hegre, Siv Anita;
Aas, Per Arne;
Slupphaug, Geir;
Drabløs, Finn;
Sætrom, Pål.
(2015)
Cell cycle regulation of human DNA repair and chromatin remodeling genes.
DNA Repair
Vitenskapelig artikkel
-
Zub, Kamila;
Sousa, Mirta;
Sarno, Antonio;
Sharma, Animesh;
Dikic, Aida;
Rao, Shalini.
(2015)
Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired Melphalan resistance in multiple myeloma cells.
PLOS ONE
Vitenskapelig artikkel
2014
-
Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Vitenskapelig artikkel
-
Hagen, Lars;
Sharma, Animesh;
Aas, Per Arne;
Slupphaug, Geir.
(2014)
Off-target responses in the HeLa proteome subsequent to transient plasmid-mediated transfection.
Biochimica et Biophysica Acta - Proteins and Proteomics
Vitenskapelig artikkel
-
Wallenius, Anders;
Hauser, Jannek;
Aas, Per Arne;
Sarno, Antonio;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2014)
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Molecular Immunology
Vitenskapelig artikkel
2013
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Ericsson, Ida;
Galashevskaya, Anastasia;
Sarno, Antonio;
Aas, Per Arne.
(2013)
Genomic uracil - potent mutagen but normal intermediate in adaptive immunity.
The FEBS Journal
Sammendrag/abstract
-
Diaz, Javier Pena;
Hegre, Siv Anita;
Anderssen, Endre;
Aas, Per Arne;
Mjelle, Robin;
Gilfillan, Gregor Duncan.
(2013)
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Vitenskapelig artikkel
-
Sousa, Mirta;
Zub, Kamila Anna;
Aas, Per Arne;
Hanssen-Bauer, Audun;
Demirovic, Aida;
Sarno, Antonio.
(2013)
An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.
PLOS ONE
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Vitenskapelig artikkel
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Vitenskapelig artikkel
2010
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Sammendrag/abstract
-
Fenstad, Mona Høysæter;
Johnson, Matthew;
Roten, Linda Tømmerdal;
Aas, Per Arne;
Forsmo, Siri;
Klepper, Kjetil.
(2010)
Genetic and molecular functional characterization of variants within TNFSF13B, a positional candidate preeclampsia susceptibility gene on 13q.
PLOS ONE
Vitenskapelig artikkel
-
Monsen, Vivi A Talstad;
Sundheim, Ottar;
Aas, Per Arne;
Westbye, Marianne Pedersen;
Sousa, Mirta;
Slupphaug, Geir.
(2010)
Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Monsen, Vivi A Talstad;
Krokan, Hans Einar;
Aas, Per Arne.
(2010)
Mechanisms of alkylation damage repair by human AlkB homologues.
NTNU
Doktorgradsavhandling
2009
-
Aas, Per Arne;
Diaz, Javier Pena;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Skorpen, Frank.
(2009)
Overexpression of transcription factor AP-2 stimulates the P-A promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression.
DNA Repair
Vitenskapelig artikkel
-
Langevin, C;
Maidou-Peindara, P;
Aas, Per Arne;
Jacquot, G;
Otterlei, Marit;
Slupphaug, Geir.
(2009)
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect.
Journal of Virology
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
2008
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
2007
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
2006
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Vitenskapelig artikkel
2004
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Falnes, Pål;
Bjoras, M;
Bjørås, Magnar;
Aas, PA;
Sundheim, Ottar;
Seeberg, E.
(2004)
Substrate specificities of bacterial and human AlkB proteins.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2003
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
2002
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
2001
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
2000
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
1999
-
Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal
Vitenskapelig artikkel
1998
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences.
Fagbok
-
Skorpen, Frank;
Alm, B.;
Skjelbred, Camilla;
Aas, P.A.;
Krokan, Hans Einar.
(1998)
Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells.
Chemico-Biological Interactions
Vitenskapelig artikkel
-
Haug, T.;
Skorpen, Frank;
Aas, P.A.;
Malm, V;
Skjelbred, Camilla;
Krokan, Hans Einar.
(1998)
Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Skorpen, Frank;
Skjelbred, Camilla;
Aas, P.A.;
Alm, B.;
Schønberg, S.A.;
Krokan, Hans Einar.
(1998)
Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Ravlo, Erlend;
Sousa, Mirta;
Andresen, Lise Lima;
Holberg-Petersen, Mona;
Klundby, Ingvild;
Aas, Per Arne.
(2023)
A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles.
Scientific Reports
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Iveland, Tobias Solli;
Buchinger, Edith;
Hagen, Lars;
Liabakk, Nina-Beate;
Aas, Per Arne.
(2021)
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Hegre, Siv Anita;
Samdal, Helle;
Klima, Antonin;
Stovner, Endre Bakken;
Nørsett, Kristin Gabestad;
Liabakk, Nina-Beate.
(2021)
Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation.
Scientific Reports
Vitenskapelig artikkel
-
Steen, Kristian Wollen;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Rabe, Renana;
Iveland, Tobias Solli;
Aas, Per Arne.
(2021)
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Fenstad, Mona H.;
Biza, Svetlana;
Zusinaite, Eva;
Reisberg, Tuuli.
(2020)
Potential Antiviral Options against SARS-CoV-2 Infection. Viruses.
Viruses
Vitenskapelig artikkel
-
Yang, Mingyi;
Lin, Xiaolin;
Segers, Filip;
Suganthan, Rajikala;
Hildrestrand, Gunn Annette;
Rinholm, Johanne Egge.
(2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation.
Cell reports
Vitenskapelig artikkel
-
Ianevski, Aleksandr;
Yao, Rouan;
Biza, Svetlana;
Zusinaite, Eva;
Mannik, Andres;
Kivi, Gaily.
(2020)
Identification and Tracking of Antiviral Drug Combinations.
Viruses
Vitenskapelig artikkel
-
Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Montaldo, Nicola Pietro;
Bordin, Diana Lilian;
Brambilla, Alessandro;
Rösinger, Marcel;
Martin, Sarah Fordyce;
Bjørås, Karine Øian.
(2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nature Communications
Vitenskapelig artikkel
-
Dewan, Alisa Elinsdatter;
Xing, Mengtan;
Lundbæk, Marie Benner;
Gago-Fuentes, Raquel;
Beck, Carole;
Aas, Per Arne.
(2018)
Robust DNA repair in PAXX-deficient mammalian cells.
FEBS Open Bio
Vitenskapelig artikkel
-
Buchinger, Edith;
Wiik, Siv Åshild;
Kusnierczyk, Anna;
Rabe, Renana;
Aas, Per Arne;
Kavli, Bodil Merete.
(2017)
Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2.
Biomolecular NMR Assignments
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
-
Mjelle, Robin;
Hegre, Siv Anita;
Aas, Per Arne;
Slupphaug, Geir;
Drabløs, Finn;
Sætrom, Pål.
(2015)
Cell cycle regulation of human DNA repair and chromatin remodeling genes.
DNA Repair
Vitenskapelig artikkel
-
Zub, Kamila;
Sousa, Mirta;
Sarno, Antonio;
Sharma, Animesh;
Dikic, Aida;
Rao, Shalini.
(2015)
Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired Melphalan resistance in multiple myeloma cells.
PLOS ONE
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Vitenskapelig artikkel
-
Hagen, Lars;
Sharma, Animesh;
Aas, Per Arne;
Slupphaug, Geir.
(2014)
Off-target responses in the HeLa proteome subsequent to transient plasmid-mediated transfection.
Biochimica et Biophysica Acta - Proteins and Proteomics
Vitenskapelig artikkel
-
Wallenius, Anders;
Hauser, Jannek;
Aas, Per Arne;
Sarno, Antonio;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2014)
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Molecular Immunology
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Ericsson, Ida;
Galashevskaya, Anastasia;
Sarno, Antonio;
Aas, Per Arne.
(2013)
Genomic uracil - potent mutagen but normal intermediate in adaptive immunity.
The FEBS Journal
Sammendrag/abstract
-
Diaz, Javier Pena;
Hegre, Siv Anita;
Anderssen, Endre;
Aas, Per Arne;
Mjelle, Robin;
Gilfillan, Gregor Duncan.
(2013)
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Vitenskapelig artikkel
-
Sousa, Mirta;
Zub, Kamila Anna;
Aas, Per Arne;
Hanssen-Bauer, Audun;
Demirovic, Aida;
Sarno, Antonio.
(2013)
An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.
PLOS ONE
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Vitenskapelig artikkel
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Sammendrag/abstract
-
Fenstad, Mona Høysæter;
Johnson, Matthew;
Roten, Linda Tømmerdal;
Aas, Per Arne;
Forsmo, Siri;
Klepper, Kjetil.
(2010)
Genetic and molecular functional characterization of variants within TNFSF13B, a positional candidate preeclampsia susceptibility gene on 13q.
PLOS ONE
Vitenskapelig artikkel
-
Monsen, Vivi A Talstad;
Sundheim, Ottar;
Aas, Per Arne;
Westbye, Marianne Pedersen;
Sousa, Mirta;
Slupphaug, Geir.
(2010)
Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Aas, Per Arne;
Diaz, Javier Pena;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Skorpen, Frank.
(2009)
Overexpression of transcription factor AP-2 stimulates the P-A promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression.
DNA Repair
Vitenskapelig artikkel
-
Langevin, C;
Maidou-Peindara, P;
Aas, Per Arne;
Jacquot, G;
Otterlei, Marit;
Slupphaug, Geir.
(2009)
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect.
Journal of Virology
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Vitenskapelig artikkel
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Falnes, Pål;
Bjoras, M;
Bjørås, Magnar;
Aas, PA;
Sundheim, Ottar;
Seeberg, E.
(2004)
Substrate specificities of bacterial and human AlkB proteins.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
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Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
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Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
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Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
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Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
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Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal
Vitenskapelig artikkel
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Skorpen, Frank;
Alm, B.;
Skjelbred, Camilla;
Aas, P.A.;
Krokan, Hans Einar.
(1998)
Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells.
Chemico-Biological Interactions
Vitenskapelig artikkel
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Haug, T.;
Skorpen, Frank;
Aas, P.A.;
Malm, V;
Skjelbred, Camilla;
Krokan, Hans Einar.
(1998)
Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Skorpen, Frank;
Skjelbred, Camilla;
Aas, P.A.;
Alm, B.;
Schønberg, S.A.;
Krokan, Hans Einar.
(1998)
Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
Bøker
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences.
Fagbok
Rapport
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Monsen, Vivi A Talstad;
Krokan, Hans Einar;
Aas, Per Arne.
(2010)
Mechanisms of alkylation damage repair by human AlkB homologues.
NTNU
Doktorgradsavhandling
Formidling
2022
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PosterAli, Zeeshan; Ravlo, Erlend; Aas, Per Arne; Hagen, Lars; Erlandsen, Sten Even; Ottesen, Vegar. (2022) Scalable Production of Silica-coated Magnetic Nanobeads and their Applications in Viral Diagnostics. European Colloid & Interface Society 36th European Colloid & Interface Society Conference , Chania, Crete 2022-09-04 - 2022-09-09
2019
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PosterSamdal, Helle; Hegre, Siv Anita; Klima, Antonin; Stovner, Endre Bakken; Nørsett, Kristin Gabestad; Liabakk, Nina-Beate. (2019) Functional evaluation of long non-coding RNAs with potential roles during cell replication. Keystone symposia on molecular and cellular biology Long Noncoding RNAs: From Molecular Mechanism to Functional Genetics , Whistler 2019-02-24 - 2019-02-28
2018
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PosterHegre, Siv Anita; Klima, Antonin; Stovner, Endre Bakken; Samdal, Helle; Nørsett, Kristin Gabestad; Liabakk, Nina-Beate. (2018) Long non-coding RNAs in epigenetic inheritance. Keystone Symposia on Molecular and Cellular Biology Noncoding RNAs: Form, Function, Physiology , Keystone, Colorado 2018-02-25 - 2018-03-01
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PosterSlupphaug, Geir; Wollen Steen, Kristian; Rabe, Renana; Hagen, Lars; Aas, Per Arne; Sharma, Animesh. (2018) A role of ASCC3 in the quality control of methylated mRNA. EMBO EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice , Capri 2018-10-14 - 2018-10-17
2017
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PosterHegre, Siv Anita; Samdal, Helle; Klima, Antonin; Stovner, Endre Bakken; Nørsett, Kristin; Aas, Per Arne. (2017) Long non-coding RNAs in epigenetic inheritance * Won Poster prize of 250 EUR at the EMBO|EMBL Symposium. EMBL EMBO EMBL Symposium "The Non-Coding genome" , Heidelberg 2017-09-13 - 2017-09-16
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PosterHegre, Siv Anita; Klima, Antonin; Aas, Per Arne; Liabakk, Nina-Beate; Sætrom, Pål. (2017) Meta-Analysis of RNA expression identifies human cell-cycle genes. Keystone Symposia Keystone Symposia "Noncoding RNAs: From Disease to Targeted Therapeutics" , Banff 2017-02-05 -
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PosterLundbæk, Marie Benner; Sarno, Antonio; Liabakk, Nina-Beate; Aas, Per Arne; Krokan, Hans Einar; Kavli, Bodil Merete. (2017) Mitochondrial uracil-DNA glycosylase UNG1 supports class switch recombination and genomic uracil processing in mouse B-cell. Keystone B-cells and T Follicular Helper cells: Controling Long-Lived Immunity , Whistler 2017-04-23 - 2017-04-27
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PosterKlima, Antonin; Hegre, Siv Anita; Aas, Per Arne; Liabakk, Nina-Beate; Sætrom, Pål. (2017) Meta-analysis of RNA expression identifies human cell-cycle genes. Norbis – Annual National Conference 2017-11-08 - 2017-11-10
2016
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Vitenskapelig foredragKrokan, Hans Einar; Pettersen, Henrik Sahlin; Mjelle, Robin; Hegre, Siv Anita; Sætrom, Pål; Drabløs, Finn Sverre. (2016) REGULATION OF BASE EXCISION REPAIR – CANONICAL AND NON-CANONICAL PROCESSING OF GENOMIC URACIL. Russian Academy of Sciences, Siberian branch 10th International Multiconference on Bioinformatics of Genome Regulation and Structure\Systems Biology , Akademorodok, Novosibirsk 2016-08-29 - 2016-09-03
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Vitenskapelig foredragSlupphaug, Geir; Steen, Kristian Wollen; Hagen, Lars; Aas, Per Arne; Sharma, Animesh; Vågbø, Cathrine Broberg. (2016) MMS-induced modifications in mRNA and potential roles of ASCC3/ALKBH3 . The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan , Matsue 2016-11-13 - 2016-11-17
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Vitenskapelig foredragKrokan, Hans Einar; Kavli, Bodil Merete; Pettersen, Henrik Sahlin; Sætrom, Pål; Galashevskaya, Anastasia; Sarno, Antonio. (2016) Genomic Uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan , Matsue 2016-11-13 - 2016-11-17
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Faglig foredragKrokan, Hans Einar; Slupphaug, Geir; Sætrom, Pål; Sarno, Antonio; Galashevskaya, Anastasia; Lundbæk, Marie Benner. (2016) Genomic uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. Turkish Society of Toxicology. Eurotox 2016 , Sivilla 2016-09-04 -
2013
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PosterPena-Diaz, Javier; Hegre, Siv Anita; Anderssen, Endre; Aas, Per Arne; Mjelle, Robin; Gilfillan, Gregor Duncan. (2013) Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication. Norwegian Biochemical Society Norwegian Biochemical Society Contact Meeting , Lillehammer 2013-01-31 - 2013-02-03
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PosterFonseca, Davi de Miranda; Baar, Cecilie Christensen; Assefa, Netsanet Gizaw; Moe, Elin; Liabakk, Nina-Beate; Leiros, Hanna-Kirsti S.. (2013) Thermo-sensitive human UNG-mutants. The Structural Cell Biology of DNA Repair Machines effort XII Annual SBDR Program Project Workshop , Berkeley, CA 2013-04-11 - 2013-04-13
2011
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PosterSousa, Mirta; Zub, Kamila; Aas, Per Arne; Tian, Erming; Liabakk, Nina-Beate; Young, Clifford. (2011) Switch in ATM/ATR expression and up-regulation of NHEJ proteins contribute to acquired melphalan resistance in RPMI8226 myeloma cells. 2nd nordic proteomics symposium , Copenhagen 2011-11-27 - 2011-11-29
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PosterSousa, Mirta; Zub, Kamila; Aas, Per Arne; Young, Clifford; Tian, Erming; Jensen, Ole Nørregaard. (2011) Proteomics screening identifies AKR1C proteins as potential markers for resistance in melphalan resistant RPMI8226-LR5 myeloma cells. 4th EU-USA conference on DNA base damage and repair , Oslo 2011-05-18 - 2011-05-22
2010
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Vitenskapelig foredragZub, Kamila; Sousa, Mirta; Aas, Per Arne; Young, Clifford; Tian, Erming; Johansen, Jostein. (2010) A proteomics and genomic approach to identify factors associated with melphalan resistance in multiple myeloma cells. NTNU 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. NTNU 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
2009
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Vitenskapelig foredragAas, Per Arne; Diaz, Javier Pena; Liabakk, Nina-Beate; Krokan, Hans Einar; Skorpen, Frank. (2009) Overexpression of transcription factor AP-2 stimulates the P(A) promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression. IKM Tirdagsforedrag-IKM , Medisinsk Teknisk Forskningssenter 2009-05-18 - 2009-05-18
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair 2009-06-20 - 2009-06-25
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PosterTalstad, Vivi A; Sundheim, Ottar; Aas, Per Arne; Krokan, Hans Einar. (2009) Structural basis for substrate specificity of human AlkB homologues 2 and 3. International symposium: DNA Damage Response and Repair Mechanisms , Heraklion, Crete 2009-04-20 - 2009-04-23
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PosterHegre, Siv Anita; Sætrom, Pål; Aas, Per Arne; Olsen, Lene Christin; Lundbæk, Marie Benner; Diaz, Javier Pena. (2009) Multiple microRNAs appear to regulate the DNA repair enzyme UNG2 during the cell cycle. Keystone Symposia MicroRNA and Cancer Conference , Keystone, Colorado 2009-06-10 - 2009-06-15
2008
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Vitenskapelig foredragSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance , St. Petersburg 2008-06-24 - 2008-06-26
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PosterTalstad, Vivi A; Sundheim, Ottar; Aas, Per Arne; Krokan, Hans Einar. (2008) Identification of the motif that determines double strand substrate preference of hABH2 by domain swapping between hABH3 and hABH2. DNA Repair EU Integrated Project DNA repair annual meeting 2008 , Rotterdam 2008-04-16 - 2008-04-18
2006
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PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Talstad, Vivi; Aas, Per Arne. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Erling Seeberg Symposium on DNA Repair 2006-05-28 - 2006-06-02
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PosterVågbø, Cathrine Broberg; Talstad, Vivi; Aas, Per Arne; Krokan, Hans Einar. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA. EU Integrated Project “DNA Damage Response and Rep. Mech." DNA Repair: from Molecular Mechanism to Human Disease , Noordwijkerhout 2006-04-02 - 2006-04-07
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PosterVågbø, Cathrine Broberg; Talstad, Vivi; Aas, Per Arne; Krokan, Hans Einar. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA. Universitet i Oslo Erling Seeberg Symposium on DNA repair , Henningsvær, Lofoten 2006-05-28 - 2006-06-02
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PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2006) Crystal structure of hABH3 DNA/RNA demethylase reveals a novel active-site leucine oxidation. Norwegian Biochemical Society (NBS) The Norwegian Biochemical Society 42. Contact Meeting , Storefjell, Storefjell Hotell 2006-01-19 - 2006-01-22
2005
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PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2005) Structure of the hABH3 DNA demethylase implicates an oxidized leucine residue in catalysis. 2nd ESF Functional Genomics and disease 2005-09-06 -
2003
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Populærvitenskapelig foredragAas, Per Arne. (2003) RNA-modification. "Tirsdagsmøte" , Trondheim, Norge 2003-10-14 -
2002
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Vitenskapelig foredragAas, Per Arne; Otterlei, Marit; Skorpen, Frank; Akbari, Mansour; Slupphaug, Geir; Krokan, Hans Einar. (2002) Repair of alkylated single-stranded DNA and RNA in living cells. 38.Biokjemiske kontaktmøte Functional genomics-the mosaics of life , Røros 2002-01-20 -
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PosterLauritzen, K.H; Aas, Per Arne; Krokan, Hans Einar; Skorpen, Frank. (2002) The human mitochondrial uracil-DNA glycosylase (UNG1) promoter is induced by high levels of CO2. 38.Biokjemiske kontaktmøte Functional genomics-the mosaics of life , Røros 2002-01-20 -
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PosterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Aas, Per Arne. (2002) Substrate preference and enzyme kinetics reveal distinct properties of UNG2 and SMUG1 in cellular base-excision repair; hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup. 32nd Annual Meeting of European Environmental Mutagen Society. DNA Damage and Repair Fundamental Aspects and Contribution to Human Disorders , Warsaw. Poland 2002-09-07 -
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PosterKavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Otterlei, Marit; Skorpen, Frank. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in DNA-uracil repair in the nucleus. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life , Quality Hotel Røros 2002-01-20 -
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PosterKavli, Bodil; Otterlei, Marit; Sundheim, Ottar; Akbari, Mansour; Aas, Per Arne; Krokan, Hans Einar. (2002) Biochemical and kinetic analysis of human UNG2 and SMUG1 indicate overlapping functions in uracil-DNA repair in the nucleus. Mutagenesis and Carcinogenesis, Gordon Research Conference , Ventura, California, USA 2002-03-08 -
2001
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Populærvitenskapelig foredragAas, Per Arne. (2001) Regulation of the UNG gene. "Tirsdagsmøte" populærvitenskapelig foredrag. , Medisinsk Teknisk Senter 2001-12-04 -
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PosterSlupphaug, Geir; Skorpen, Frank; Nilsen, H.; Fenstad, M.; Rosello, Ch.; Otterlei, Marit. (2001) Functional implications of the UNG2 regulatory domain in BER and transcription regulation. Workshop DNA repair: Interplay with other cellular processes , Noordwijkerhout, The Netherlands, February 25 - March 2, 2001
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PosterSundheim, Ottar; Otterlei, Marit; Kavli, Bodil; Skorpen, Frank; Aas, Per Arne; Krokan, Hans Einar. (2001) Structure-function analysis of the human uracil-DNA glycosylase hSMUG1. Sixth International School on the Crystallography of Biological Macromolecules. , Como, Italy 2001-05-17 -
1998
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Populærvitenskapelig foredragAas, Per Arne. (1998) Studier av promotorregulering i eukaryote celler. Storlienmøte , Storlien
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PosterHaug, Terje; Aas, Per Arne; Skorpen, Frank; Malm, Veslemøy; Skjelbred, Camilla; Krokan, Hans Einar. (1998) Regulation of expression of nuclear and mitocondrialforms of human uracil-DNA glycosylase. Norsk Biokjmisk Vintermøte , Lillehammer