Nadra Jesmine Nilsen
Om
Research Scientist at the Centre of Molecular Inflammation Research (CEMIR), Center for Myeloma Research and the Colorectal Cancer (CRC) Research Center
My research focuses on basic mechanisms of innate immunity. In particular, I am interested in how signaling pattern recognition receptors (PRRs) recognize and respond to microbial and endogenous components, and how this shapes the subsequent immune response. I am currently interested in how PRR signaling affects cancer progression, with emphasis on the cancers Multiple Myeloma and colorectal cancer.
Publikasjoner
2017
-
Bugge, Marit;
Bergstrøm, Bjarte;
Eide, Oda K.;
Solli, Helene;
Kjønstad, Ingrid Fadum;
Stenvik, Jørgen;
Espevik, Terje;
Nilsen, Nadra J..
(2017)
Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Selective Cytokine Production and Promotes Invasiveness.
Journal of Biological Chemistry
Vitenskapelig artikkel
2016
-
Moen, Siv Helen;
Westhrin, Marita;
Zahoor, Muhammad;
Nørgaard, Nikolai Nordberg;
Hella, Hanne;
Størdal, Berit Fladvad;
Sundan, Anders;
Nilsen, Nadra J.;
Sponaas, Anne-Marit;
Standal, Therese.
(2016)
Caspase-8 regulates the expression of pro- and
anti-inflammatory cytokines in human bone
marrow-derived mesenchymal stromal cells.
Immunity,Inflammation and Disease
Vitenskapelig artikkel
-
Bugge, Marit;
Nilsen, Nadra J.;
Espevik, Terje.
(2016)
Toll-Like Receptor 3 Signaling in Intestinal Epithelial Cells.
Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
2015
-
Nilsen, Nadra;
I., Vladimer Gregory;
Stenvik, Jørgen;
Ørning, Mathias Pontus;
Zeid-Kilani, Maria Vanessa;
Bugge, Marit;
Bergstrøm, Bjarte;
Conlon, Joseph;
Husebye, Harald;
Amy, Hise.
(2015)
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
Journal of Biological Chemistry
Vitenskapelig artikkel
2013
-
Østvik, Ann Elisabet;
Granlund, Atle;
Bugge, Marit;
Nilsen, Nadra;
Torp, Sverre Helge;
Waldum, Helge;
Damås, Jan Kristian;
Espevik, Terje;
Sandvik, Arne Kristian.
(2013)
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation.
Inflammatory Bowel Diseases
Vitenskapelig artikkel
2012
-
Østvik, Ann Elisabet;
Nilsen, Nadra;
Granlund, Atle;
Torp, Sverre Helge;
Flatberg, Arnar;
Waldum, Helge;
Espevik, Terje;
Damås, Jan Kristian;
Sandvik, Arne Kristian.
(2012)
Enhanced expression of CXCL10 in inflammatory bowel disease-role of mucosal TLR3 stimulation.
Journal of Crohn’s and Coltis Supplements
Konferanseabstract
2010
-
Etokebe, GE;
Skjeldal, F;
Nilsen, Nadra;
Rodionov, Dmitrii;
Knezevic, Jelena;
Bulat-Kardum, Ljiljana;
Espevik, Terje;
Bakke, Oddmund;
Dembic, Zlatko.
(2010)
Toll-Like Receptor 2 (P631H) Mutant Impairs Membrane Internalization and is a Dominant Negative Allele.
Scandinavian Journal of Immunology
Vitenskapelig artikkel
-
Husebye, Harald;
Aune, Marie Hjelmseth;
Stenvik, Jørgen;
Samstad, Eivind Ottersen;
Skjeldal, Frode Miltzow;
Halaas, Øyvind;
Nilsen, Nadra;
Stenmark, Harald Alfred;
Latz, Eicke;
Lien, Egil.
(2010)
The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes.
Immunity
Vitenskapelig artikkel
2009
-
Iversen, Ann-Charlotte;
Steinkjer, Bjørg;
Nilsen, Nadra;
Bohnhorst, Janne Øvrebø;
Moen, Siv Helen;
Vik, Randi;
Stephens, Phil;
Thomas, DW;
Benedict, Chris A.;
Espevik, Terje.
(2009)
A proviral role for CpG in cytomegalovirus infection.
Journal of Immunology
Vitenskapelig artikkel
2008
-
Nilsen, Nadra;
Deininger, S;
Nonstad, Unni;
Skjeldal, F;
Husebye, Harald;
Rodionov, D;
Aulock, S von;
Hartung, T;
Lien, E;
Lien, E.
(2008)
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36.
Journal of Leukocyte Biology
Vitenskapelig artikkel
-
Nilsen, Nadra;
Espevik, Terje;
Lien, Egil.
(2008)
TOLL-LIKE RECEPTOR 2 EXPRESSION, REGULATION AND SIGNALING.
Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
2005
-
Manukyan, M;
Triantafilou, K;
Triantafilou, M;
Mackie, A;
Nilsen, Nadra Jesmine;
Espevik, Terje;
Wiesmullers, KH;
Ulmer, AJ;
Heine, H.
(2005)
Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.
European Journal of Immunology
Vitenskapelig artikkel
2004
-
Latz, E;
Schoenemeyer, A;
Visintin, A;
Fitzgerald, KA;
Monks, BG;
Knetter, Cathrine;
Lien, E;
Nilsen, Nadra;
Espevik, Terje;
Golenbock, DT.
(2004)
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Nature Immunology
Vitenskapelig artikkel
-
Nilsen, Nadra;
Nonstad, Unni;
Kahn, Naseema;
Knetter, Cathrine;
Akira, Shizuo;
Sundan, Anders;
Espevik, Terje;
Lien, Egil.
(2004)
Lipopolysaccharide and Double-stranded RNA Up-regulate Toll-like Receptor 2 Independently of Myeloid Differentiation Factor 88.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Campa, Christiana;
Holtan, Synnøve;
Nilsen, Nadra;
Bjerkan, Tonje M;
Stokke, Bjørn Torger;
Skjåk-Bræk, Gudmund.
(2004)
Biochemical analysis of the processive mechanism for epimerization of alginate by mannuronan C-5 epimerase AlgE4.
Biochemical Journal
Vitenskapelig artikkel
2003
-
Schjetne, KW;
Thompson, KM;
Nilsen, Nadra;
Flo, Trude Helen;
Fleckenstein, B;
Iversen, JG;
Espevik, Terje;
Bogen, B.
(2003)
Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target.
Journal of Immunology
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Latz, E;
Schoenemeyer, A;
Visintin, A;
Fitzgerald, KA;
Monks, BG;
Knetter, Cathrine;
Lien, E;
Nilsen, Nadra;
Espevik, Terje;
Golenbock, DT.
(2004)
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Nature Immunology
Vitenskapelig artikkel
-
Schjetne, KW;
Thompson, KM;
Nilsen, Nadra;
Flo, Trude Helen;
Fleckenstein, B;
Iversen, JG;
Espevik, Terje;
Bogen, B.
(2003)
Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target.
Journal of Immunology
Vitenskapelig artikkel
-
Bugge, Marit;
Bergstrøm, Bjarte;
Eide, Oda K.;
Solli, Helene;
Kjønstad, Ingrid Fadum;
Stenvik, Jørgen;
Espevik, Terje;
Nilsen, Nadra J..
(2017)
Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Selective Cytokine Production and Promotes Invasiveness.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Iversen, Ann-Charlotte;
Steinkjer, Bjørg;
Nilsen, Nadra;
Bohnhorst, Janne Øvrebø;
Moen, Siv Helen;
Vik, Randi;
Stephens, Phil;
Thomas, DW;
Benedict, Chris A.;
Espevik, Terje.
(2009)
A proviral role for CpG in cytomegalovirus infection.
Journal of Immunology
Vitenskapelig artikkel
-
Østvik, Ann Elisabet;
Nilsen, Nadra;
Granlund, Atle;
Torp, Sverre Helge;
Flatberg, Arnar;
Waldum, Helge;
Espevik, Terje;
Damås, Jan Kristian;
Sandvik, Arne Kristian.
(2012)
Enhanced expression of CXCL10 in inflammatory bowel disease-role of mucosal TLR3 stimulation.
Journal of Crohn’s and Coltis Supplements
Konferanseabstract
-
Moen, Siv Helen;
Westhrin, Marita;
Zahoor, Muhammad;
Nørgaard, Nikolai Nordberg;
Hella, Hanne;
Størdal, Berit Fladvad;
Sundan, Anders;
Nilsen, Nadra J.;
Sponaas, Anne-Marit;
Standal, Therese.
(2016)
Caspase-8 regulates the expression of pro- and
anti-inflammatory cytokines in human bone
marrow-derived mesenchymal stromal cells.
Immunity,Inflammation and Disease
Vitenskapelig artikkel
-
Etokebe, GE;
Skjeldal, F;
Nilsen, Nadra;
Rodionov, Dmitrii;
Knezevic, Jelena;
Bulat-Kardum, Ljiljana;
Espevik, Terje;
Bakke, Oddmund;
Dembic, Zlatko.
(2010)
Toll-Like Receptor 2 (P631H) Mutant Impairs Membrane Internalization and is a Dominant Negative Allele.
Scandinavian Journal of Immunology
Vitenskapelig artikkel
-
Østvik, Ann Elisabet;
Granlund, Atle;
Bugge, Marit;
Nilsen, Nadra;
Torp, Sverre Helge;
Waldum, Helge;
Damås, Jan Kristian;
Espevik, Terje;
Sandvik, Arne Kristian.
(2013)
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation.
Inflammatory Bowel Diseases
Vitenskapelig artikkel
-
Nilsen, Nadra;
Deininger, S;
Nonstad, Unni;
Skjeldal, F;
Husebye, Harald;
Rodionov, D;
Aulock, S von;
Hartung, T;
Lien, E;
Lien, E.
(2008)
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36.
Journal of Leukocyte Biology
Vitenskapelig artikkel
-
Manukyan, M;
Triantafilou, K;
Triantafilou, M;
Mackie, A;
Nilsen, Nadra Jesmine;
Espevik, Terje;
Wiesmullers, KH;
Ulmer, AJ;
Heine, H.
(2005)
Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.
European Journal of Immunology
Vitenskapelig artikkel
-
Nilsen, Nadra;
Nonstad, Unni;
Kahn, Naseema;
Knetter, Cathrine;
Akira, Shizuo;
Sundan, Anders;
Espevik, Terje;
Lien, Egil.
(2004)
Lipopolysaccharide and Double-stranded RNA Up-regulate Toll-like Receptor 2 Independently of Myeloid Differentiation Factor 88.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Campa, Christiana;
Holtan, Synnøve;
Nilsen, Nadra;
Bjerkan, Tonje M;
Stokke, Bjørn Torger;
Skjåk-Bræk, Gudmund.
(2004)
Biochemical analysis of the processive mechanism for epimerization of alginate by mannuronan C-5 epimerase AlgE4.
Biochemical Journal
Vitenskapelig artikkel
-
Husebye, Harald;
Aune, Marie Hjelmseth;
Stenvik, Jørgen;
Samstad, Eivind Ottersen;
Skjeldal, Frode Miltzow;
Halaas, Øyvind;
Nilsen, Nadra;
Stenmark, Harald Alfred;
Latz, Eicke;
Lien, Egil.
(2010)
The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes.
Immunity
Vitenskapelig artikkel
-
Nilsen, Nadra;
I., Vladimer Gregory;
Stenvik, Jørgen;
Ørning, Mathias Pontus;
Zeid-Kilani, Maria Vanessa;
Bugge, Marit;
Bergstrøm, Bjarte;
Conlon, Joseph;
Husebye, Harald;
Amy, Hise.
(2015)
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
Journal of Biological Chemistry
Vitenskapelig artikkel
Studentoppgave eller avhandling
-
Bugge, Marit;
Nilsen, Nadra J.;
Espevik, Terje.
(2016)
Toll-Like Receptor 3 Signaling in Intestinal Epithelial Cells.
Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
-
Nilsen, Nadra;
Espevik, Terje;
Lien, Egil.
(2008)
TOLL-LIKE RECEPTOR 2 EXPRESSION, REGULATION AND SIGNALING.
Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
Formidling
2018
-
KonferanseposterBugge, Marit; EIde, Oda Kamilla; Solli, Helene; Kjønstad, Ingrid Fadum; Stenvik, Jørgen; Bergstrøm, Bjarte; Espevik, Terje; Nilsen, Nadra. (2018) SURFACE TOLL-LIKE RECEPTOR 3 EXPRESSION IN METASTATIC INTESTINAL EPITHELIAL CELLS INDUCES INFLAMMATORY CYTOKINE PRODUCTION AND PROMOTES INVASIVENESS. Toll 2018 Translating Innate Immunity
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KonferanseforedragBugge, Marit; Espevik, Terje; Nilsen, Nadra. (2018) Altered Toll-Like Receptor Expression and Signaling in Colorectal Cancer Cells promotes Invasiveness. 2nd International NTNU Symposium Current and Future Clinical Biomarkers of Cancer: From diagnosis to immunotherapy – why is precision medicine so difficult?
2017
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KonferanseposterBugge, Marit; Bergstrøm, Bjarte Aune; Eide, Oda K.; Solli, Helene; Kjønstad, Ingrid Fadum; Stenvik, Jørgen; Espevik, Terje; Nilsen, Nadra. (2017) Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Inflammatory Cytokine Production and Promotes Invasiveness. Development of Tissue- and Pathogen-specific Cellular Innate Immunity
2015
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KonferanseposterNilsen, Nadra J.; Espevik, Terje; Vladimer, G; Stenvik, Jørgen; Orning, M. Pontus A.; Zeid-Kilani, Maria Vanessa; Bugge, Marit; Bergstrøm, Bjarte; Conlon, Joseph; Husebye, Harald. (2015) THE ADAPTOR PROTEINS TRAM AND TRIF MEDIATE TOLL-LIKE RECEPTOR 2 SIGNALING. Innate Immune Memory
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KonferanseposterNilsen, Nadra J.; Espevik, Terje; Gjerdingen, Thea Johannne; Bugge, Marit; Kjønstad, Ingrid Fadum. (2015) A TOLL-LIKE RECEPTOR 7/8 LIGAND SECRETED BY MYELOMA CELLS INDUCES PRIMARY BONE MARROW STROMAL CELLS TO PRODUCE CYTOKINES THAT PROMOTE MYELOMA SURVIVAL. Toll2015 Targeting Innate Immunity
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ForedragNilsen, Nadra J.; Espevik, Terje; Vladimer, G; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit; Bergstrøm, Bjarte; Conlon, Joseph; Husebye, Harald; Hise, Amy G. (2015) THE ADAPTOR PROTEINS TRAM AND TRIF MEDIATE TOLL-LIKE RECEPTOR 2 SIGNALING. Toll2015 Targeting Innate Immunity
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KonferanseposterBugge, Marit; Solli, Helene; Kjønstad, Ingrid F.; Stenvik, Jørgen; Espevik, Terje; Nilsen, Nadra J.. (2015) Metastatic Intestinal Epithelial Cells Express Surface Toll-Like Receptor 3. Toll 2015 Targeting Innate Immunity
2013
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KonferanseposterBugge, Marit; Nilsen, Nadra; Espevik, Terje. (2013) A potential role for TLR3 expression and TLR3 mediated responses in the progression of colorectal cancer. Keystone Symposia on Cancer Immunology and Immunotherapy
2010
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KonferanseforedragNilsen, Nadra; Espevik, Terje; Lien, Egil. (2010) The Adaptor Proteins TRAM and TRIF mediate Toll-Like Receptor 2- induced RANTES/CCL5 Release. 14th International Congress of Immunology
2008
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KonferanseposterIversen, Ann-Charlotte; Steinkjer, Bjørg; Nilsen, Nadra; Bohnhorst, Janne Øvrebø; Moen, Siv Helen; Vik, Randi; Stephens, Phil; Thomas, David W.; Benedict, Chris A.; Espevik, Terje. (2008) A proviral role for CpG in cytomegalovirus infection. Toll 2008 Conference
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KonferanseposterNilsen, Nadra; Deininger, Susanne; Nonstad, Unni; Skjeldal, Frode; Husebye, Harald; Rodionov, Dmitrii; Aulock, Sonja von; Hartung, Thomas; Lien, Egil; Bakke, Oddmund. (2008) Toll-like receptor 2 signaling occurs preferentially at the plasma membrane, independent of internalization, and is facilitated by both CD36 and CD14. TOLL2008
2004
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KonferanseforedragNilsen, Nadra; Espevik, Terje. (2004) Molecular associations of lipopeptides with CD14 and TLR2. Toll 2004
-
KonferanseforedragNilsen, Nadra; Nonstad, U; Knetter, Cathrine; Sundan, Anders; Espevik, Terje; Lien, Egil. (2004) Lipopolysaccharide- and dsRNA-Induced Upregulation of Mouse Tollike Receptor 2 is Myeloid Differentiation Factor 88-Independent. Toll 2004
2003
-
KonferanseposterManoukian, M; Triantafilou, M; Triantafilou, K; Mackie, A; Nilsen, Nadra; Espevik, Terje; Wiesmüller, K.H.; Ulmer, A. J.; Heine, H. (2003) Molecular mechanisms of lipopeptide interaction with CD14 and TLR2. 34th Annual Meeting of the German Society of Immunology
2002
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KonferanseposterNilsen, Nadra; Nonstad, Unni; Sundan, Anders; Espevik, Terje; Lien, Egil. (2002) Function and expression of mouse Toll-like receptor 2, a receptor for bacterial, fungal and viral components. The 7th Biennial Conference of the International Endotoxin Society.