Marianne Doré Hansen
Bakgrunn og aktiviteter
Research focus: Hepatitis C virus-driven inflammation in liver pathology and hepatocellular carcinoma.
Hepatitis C virus (HCV) is a major cause of chronic liver disease, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC) worldwide and poses a significant global health threat. Lipid accumulation in the liver, termed hepatic steatosis is a significant risk factor for development of HCC in chronic HCV patients independently of other known risk factors, which suggest the possibility that amelioration of hepatic steatosis may prevent HCC. The project rely on basic research, in vitro and in vivo models, advanced cellular imaging and unique biobanks to study mechanisms that drive disease progression. The project aim to increase our understanding of factors driving development of severe liver disease, which is fundamental for developing interventional and therapeutic strategies.
- Researcher at Department of Clinical and Molecular Medicine, NTNU 2018 – now
- Visiting scientist at Institut Pasteur, Paris, France, Department of Virology, Hepacivirus and innate immunity, 2015 - 2018
- Post doctor at Department of Laboratory medicine, Children’s and Women’s Health, NTNU 2015-2018
- Visiting scientist at Institut Pasteur, Paris, France, Department of Virology, Hepacivirus and innate immunity, 2013
- PhD in Molecular Medicine in Marit W. Anthonsens lab, Department of Laboratory Medicine, Children’s and Women’s Health, NTNU, 2010-2015
- Senior Engineer, Department of Biology, NTNU, 2000-2010
- M.Sc. Biotechnology, University in Tromsø, 1996 – 1999
Vitenskapelig, faglig og kunstnerisk arbeid
Et utvalg av nyere tidsskriftspublikasjoner, kunstneriske produksjoner, bok, inklusiv bokdeler og rapport-del. Se alle publikasjoner i databasen
- (2017) Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT. Scientific Reports. vol. 7 (1).
- (2017) Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M. Proceedings of the National Academy of Sciences of the United States of America. vol. 114 (17).
- (2014) Effects on Development, Growth Responses and Thyroid-Hormone Systems in Eyed-Eggs and Yolk-Sac Larvae of Atlantic Salmon (Salmo salar) Continuously Exposed to 3,3′,4,4′-Tetrachlorobiphenyl (PCB-77). Journal of Toxicology and Environmental Health, Part A. vol. 7 (9-11).
- (2009) Neural aromatase transcript and protein levels in Atlantic salmon (Salmo salar) are modulated by the ubiquitous water pollutant, 4-nonylphenol. General and Comparative Endocrinology. vol. 164 (1).
- (2005) Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner. Journal of Molecular Diagnostics. vol. 7.
- (2015) Interplay of single´stranded RNA viruses with autophagy: Intracellular mechanisms and functional impact. 2015. ISBN 978-82-326-0808-9.