Bakgrunn og aktiviteter
Hovedmålet for vår forskning er et utvikle kliniske anvendelser av avanserte optiske avbildningsteknikker, med en spesiell fokus på ikke-linære mikroskopi.
We are currently investigating the use of multiphoton microscopy (MPM) for characterizing various types of tissue. MPM has the advantage that it can be used to create 3 dimensional images, with submicron resolution and no exogenous staining. For more information about the project, please visit folk.ntnu.no/lilledah
Vitenskapelig, faglig og kunstnerisk arbeid
Et utvalg av nyere tidsskriftspublikasjoner, kunstneriske produksjoner, bok, inklusiv bokdeler og rapport-del. Se alle publikasjoner i databasen
- (2018) Characterization of cellular and matrix alterations in the early pathogenesis of osteochondritis dissecans in pigs using second harmonic generation and two-photon excitation fluorescence microscopy. Journal of Orthopaedic Research. vol. 36 (8).
- (2018) Comparison of compressive stress-relaxation behavior in osteoarthritic (ICRS graded) human articular cartilage. International Journal of Molecular Sciences. vol. 19 (2).
- (2018) Automated calibration and control for polarization-resolved second harmonic generation on commercial microscopes. PLoS ONE. vol. 13 (4).
- (2018) Analyzing the feasibility of discriminating between collagen types I and II using polarization‐resolved second harmonic generation. Journal of Biophotonics.
- (2017) Non-linear optical microscopy of cartilage canals in the distal femur of young pigs may reveal the cause of articular osteochondrosis. BMC Veterinary Research. vol. 13.
- (2017) The effect of changing the numerical aperture in SHG microscopy of cartilage. Progress in Biomedical Optics and Imaging. vol. 10069.
- (2017) Non-linear optical microscopy as a novel quantitative and label-free imaging modality to improve the assessment of tissue-engineered cartilage. Osteoarthritis and Cartilage. vol. 25 (10).
- (2016) Second harmonic generation imaging reveals a distinct organization of collagen fibrils in locations associated with cartilage growth. Connective Tissue Research. vol. 57 (5).
- (2015) Alterations in collagen fibre patterns in breast cancer. A premise for tumour invasiveness?. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). vol. 123 (1).
- (2015) Optical investigation of osteoarthritic human cartilage (ICRS grade) by confocal Raman spectroscopy: a pilot study. Analytical and Bioanalytical Chemistry. vol. 407 (26).
- (2015) Nonlinear optical microscopy of early stage (ICRS Grade-I) osteoarthritic human cartilage. Biomedical Optics Express. vol. 6 (5).
- (2015) Polarization second harmonic generation microscopy provides quantitative enhanced molecular specificity for tissue diagnostics. Journal of Biophotonics. vol. 8 (9).
- (2015) Single Cell Confocal Raman Spectroscopy of Human Osteoarthritic Chondrocytes: A Preliminary Study. International Journal of Molecular Sciences. vol. 16 (5).
- (2015) Second harmonic generation imaging in tissue engineering and cartilage pathologies. Progress in Biomedical Optics and Imaging. vol. 9329.
- (2015) Novel imaging technologies for characterization of microbial extracellular polysaccharides. Frontiers in Microbiology. vol. 6 (MAY).
- (2014) Ultrasound-enhanced drug delivery in prostate cancer xenografts by nanoparticles stabilizing microbubbles. Journal of Controlled Release. vol. 187.
- (2014) Mueller matrix three-dimensional directional imaging of collagen fibers. Journal of Biomedical Optics. vol. 19 (2).
- (2014) Analysis of human knee osteoarthritic cartilage using polarization sensitive second harmonic generation microscopy. Proceedings of SPIE, the International Society for Optical Engineering. vol. 9129.
- (2014) Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels. PLoS ONE. vol. 9 (3).
- (2013) Identification of functional structures in tissue engineered cartilage: from nm to macro scale. European Cells and Materials. vol. 26.