Bakgrunn og aktiviteter
The Inflammatory Cell Death Group.
We are a new research group situated at the Centre for Molecular Inflammation Research (Cemir), a Norwegian Research Council Centre of Excellence. We are affiliated with the Autophagy and Oxidative Stress Group and the Centre of Myeloma Research. Our focus is regulation and targeting of inflammatory cell death pathways in the monocytic lineage.
We are looking for enthusiastic and skilled students (bachelor, master, PhD) and postdocs. Contact me pr. email for more information
Regulated cell death types such as apoptosis, necroptosis and pyroptosis are central in a wide range of physiological and pathological states throughout the organism. Understanding how cells initiate or suppress cell death in response to challenges such as drugs or bacterial infections is important to understand both immune responses, cellular homeostasis and drug cytotoxicity.
Our research focus is on how intracellular protection mechanisms and cell death pathways tackle stressors such as chemotherapeutic drugs, danger-associated and pathogen-associated molecular patterns (DAMPs and PAMPs). We focus on the role of the RIPK1- and RIPK3-regulated death pathways in inflammation.
Interestingly, cell death pathways are often interconnected with pathways for proliferation and cytokine production. They take important roles in both drug resistance and inflammation. De-regulation of these pathways can lead to malignant states such as cancer and cronic inflammation.
Kristian K. Starheim, Principle Investigator
Ingrid Nyhus Moen, PhD-Candidate
Merisa Klarhan, Master Student
Madhavi Bhandari, Master Student
Erling Håland, Medical Student, research program for medical students.
Work experience Starheim.
2016-present: Researcher, Centre for Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), Trondheim Norway. Young researcher qualifying grant from The Norwegian Cancer Society.
2014-2015: Visiting post doctoral researcher, UMass Medical School, Dept. Infectious diseases, Worcester MA, US.
2013-2015: Post doctoral researcher, CEMIR, NTNU.
2012 Aug-Dec: Research fellow, K.G. Jebsen Centre for Myeloma Research, NTNU
2012 Feb-Jul: Visiting scientist, NTNU.
2011 Feb - Jul: Visiting scientist, Instituto Gulbenkian de Ciência, Oeiras, Portugal.
2008 - 2012: PhD Fellowship, Dep. of Surgical Sciences/Dep. of Molecular Biology, UiB
2007 - 2008: Scientific assistant, Dep. Surgical Sciences/Dep. Molecular Biology, UiB.
2008 - 2011: Master of Philosophy, University of Bergen (UiB).
2008 - 2010: PhD, Dep. Surgical Sciences/Dep. Molecular Biology, UiB.
2003 - 2008: Undergraduate studies, Dep. Philosophy, UiB.
2005 - 2007: Master of Science, Molecular Biology, UiB.
2002 - 2005: Bachelor of Science, Molecular Biology, UiB.
Vitenskapelig, faglig og kunstnerisk arbeid
Viser et utvalg av aktivitet. Se alle publikasjoner i databasen
- (2018) Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. vol. 362 (6418).
- (2017) Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization. Bioscience Reports. vol. 37:BSR20170066 (2).
- (2016) Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells. OncoTarget. vol. 7 (43).
- (2016) Manipulation of interleukin-1β and interleukin-18 production by yersinia pestis effectors YopJ and YopM and redundant impact on virulence. Journal of Biological Chemistry. vol. 291 (19).
- (2016) Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells. Blood Cancer Journal.
- (2016) A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity. Molecular & Cellular Proteomics.
- (2015) An organellar Nα-acetyltransferase, Naa60, acetylates cytosolic n termini of transmembrane proteins and maintains golgi integrity. Cell reports. vol. 10 (8).
- (2013) Molekylær medisin som uttalt hybrid aktivitet - Å omsetje Latour tilbake til laboratoriet. Agora : Journal for metafysisk spekulasjon.
- (2012) Protein N-terminal acetyltransferases: when the start matters. TIBS -Trends in Biochemical Sciences. Regular ed.. vol. 37 (4).
- (2010) The Chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. Molecular and Cellular Biology. vol. 30 (8).
- (2009) A novel human NatA N-alpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). BMC Biochemistry. vol. 10.
- (2009) Knockdown of the human N-alpha-acetyltransferace complex C (hNatC) leads to p53-dependent apoptosis and aberrant hArl8b localization. Molecular and Cellular Biology. vol. 29 (13).
- (2009) Composition and biological significance of the human N-alpha-terminal acetyltransferases. BMC Proceedings. vol. 3.
- (2008) Identification of the human N-alpha-acetyltransferase complex B (hnatB): a complex important for cell-cycle progression. Biochemical Journal. vol. 415.
- (2011) Knowledge production in experimental molecular medicine - Primers for a reflexive life knowledge. 2011.
- (2010) The human protein N-α-acetyltransferase complexes hNatA, hNatB, and hNatC. Universitetet i Bergen. 2010. ISBN 978-82-308-0991-4.
- (2007) A study of novel N-alpha-acetyltransferase complexes NatB & NatC. Universitetet i Bergen. 2007.