Bakgrunn og aktiviteter

The Inflammatory Cell Death Group.

We are a new research group situated at the Centre for Molecular Inflammation Research (Cemir), a Norwegian Research Council Centre of Excellence. We are affiliated with the Autophagy and Oxidative Stress Group and the Centre of Myeloma Research. Our focus is regulation and targeting of inflammatory cell death pathways in the monocytic lineage.

We are looking for enthusiastic and skilled students (bachelor, master, PhD) and postdocs. Contact me pr. email for more information

Research.

Regulated cell death types such as apoptosis, necroptosis and pyroptosis are central in a wide range of physiological and pathological states throughout the organism.  Understanding how cells initiate or suppress cell death in response to challenges such as drugs or bacterial infections is important to understand both immune responses, cellular homeostasis and drug cytotoxicity.

Our research focus is on how intracellular protection mechanisms and cell death pathways tackle stressors such as chemotherapeutic drugs, danger-associated and pathogen-associated molecular patterns (DAMPs and PAMPs). We focus on the role of the RIPK1- and RIPK3-regulated death pathways in inflammation.

Interestingly, cell death pathways are often interconnected with pathways for proliferation and cytokine production. They take important roles in both drug resistance and inflammation. De-regulation of these pathways can lead to malignant states such as cancer and cronic inflammation.

Members.

Kristian K. Starheim, Principle Investigator

Ingrid Nyhus Moen, PhD-Candidate

Merisa Klarhan, Master Student

Madhavi Bhandari, Master Student

Erling Håland, Medical Student, research program for medical students.

Work experience Starheim.

2016-present: Researcher, Centre for Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), Trondheim Norway. Young researcher qualifying grant from The Norwegian Cancer Society.

2014-2015: Visiting post doctoral researcher, UMass Medical School, Dept. Infectious diseases, Worcester MA, US.

2013-2015: Post doctoral researcher, CEMIR, NTNU.

2012 Aug-Dec: Research fellow, K.G. Jebsen Centre for Myeloma Research, NTNU

2012 Feb-Jul: Visiting scientist, NTNU.

2011 Feb - Jul: Visiting scientist, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

2008 - 2012: PhD Fellowship, Dep. of Surgical Sciences/Dep. of Molecular Biology, UiB

2007 - 2008: Scientific assistant, Dep. Surgical Sciences/Dep. Molecular Biology, UiB.

Education

2008 - 2011: Master of Philosophy, University of Bergen (UiB).

2008 - 2010: PhD, Dep. Surgical Sciences/Dep. Molecular Biology, UiB.

2003 - 2008: Undergraduate studies, Dep. Philosophy, UiB.

2005 - 2007:  Master of Science, Molecular Biology, UiB.

2002 - 2005: Bachelor of Science, Molecular Biology, UiB.

Vitenskapelig, faglig og kunstnerisk arbeid

Viser et utvalg av aktivitet. Se alle publikasjoner i databasen

Tidsskriftspublikasjoner

Rapport/avhandling

  • Starheim, Kristian Kobbenes; De Cuzzani, Paola Maria; Strand, Roger. (2011) Knowledge production in experimental molecular medicine - Primers for a reflexive life knowledge. 2011.
  • Starheim, Kristian Kobbenes. (2010) The human protein N-α-acetyltransferase complexes hNatA, hNatB, and hNatC. Universitetet i Bergen. 2010. ISBN 978-82-308-0991-4.
  • Starheim, Kristian Kobbenes; Lillehaug, Johan; Arnesen, Thomas. (2007) A study of novel N-alpha-acetyltransferase complexes NatB & NatC. Universitetet i Bergen. 2007.