Hans Einar Krokan
Om
Short CV
BIOGRAPHICAL SKETCH
NAME |
POSITION TITLE |
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Hans Einar Krokan |
Professor/Chairman |
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EDUCATION/TRAINING |
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INSTITUTION AND LOCATION |
DEGREE |
YEAR(s) |
FIELD OF STUDY |
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M.D |
1970 |
Medicine |
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Ph.D. |
1977 |
Biochemistry |
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A. Positions and Honors
Positions and Employment
1970-1972 Internship, in surgery, internal medicine and community medicine
1972 Doctor in the air force (captain), Ørlandet military airport
1972-1977 Research fellow,
1977-1979 Post doctoral fellow (Fogarty International Fellowship),
1979-1985 Associate professor in biochemistry,
1983-1984 Visiting scientist, (Stipend from International Cancer Union, Eleanor Roosevelt Awardee), National Cancer Institute, Lab. Human Carcinogenesis,
1985-1988 Department head, Department of biotechnology, Norsk Hydro Research Centre Porsgrunn, from 1987 Director of Research, Biomedical Section (responsible for biotechnology, organic chemistry and preclinical- and clinical medicine)
1988-1993 Professor at
1993-present Professor in medicine/molecular Biology, Medicine,
1990-2002 Director/Chairman,
2006- Director/Chairman, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (formerly University of Trondheim)
2006- Norwegian delegate ESFRI (European Strategy Forum for Research Infrastructures) Biological and medical Road Map Working Group
Honors
1977-1979 Fogarty International Fellowship
1983 Eleanor Roosevelt Awardee
1994 Elected member of The Royal Norwegian Academy of Science and Letters
1997 Honorary member of the Norwegian Biochemical Society
2000 Elected member of the European Molecular Biology Organization (EMBO)
2004 Anders Jahre’s Award for Medical Research; “For his groundbreaking DNA research” (a prize given annually to one/two scientist(s) in the 5 Nordic countries).
2008 King Olav Vs Prize for Cancer Research
Research experience and interests:
Hans E. Krokan has established research groups within DNA replication, genome maintenance and DNA repair, omega-3 fatty acids research, and research on predisposition to lung cancer. He has also established extensive research programs in an industrial company (Norsk
B. Selected peer-reviewed publications (from approximately 150 scientific articles in international journals, mostly within DNA replication and DNA repair since 1975).
Krokan, H.E. and Wittwer, C. (1981) Uracil-DNA glycosylase: General properties substrate specificity and effect of uracil analogs. Nucleic Acids Res. vol. 5, 2599-2613.
Slupphaug, G., Olsen, L.C., Aasland, R., Helland, D.E. and Krokan, H.E. (1991). Cell cycle kinetics and hybrid arrest identifies a major uracil-DNA glycosylase. Nucl. Acids Res. 19, 5131-5137
Slupphaug, G., Markussen, F.H., Olsen, L.C., Aasland, R., Aarsæther, N., Bakke, O., Krokan, H.E. and Helland, D.E. and (1993). Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene. Nucl. Acids Res. 21, 2579-2584
Slupphaug, G., Eftedal, I., Kavli, B., Bharati, S., Helle, N., Haug, T., Levine, D.W. and Krokan, H.E. (1995) Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG-gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase. Biochemistry 34, 128-138
Mol, C.D., Arvai, A.S., Slupphaug, G., Kavli, B., Alseth, I., Krokan, H.E. and Tainer, J.A. (1995) Crystal Structure and mutational analysis of Human Uracil-DNA glycosylase: Structural basis for specificity and catalysis. Cell 80, 869-878
Mol, C.D., Arvai, A.S., Sanderson, R.J., Slupphaug, G., Kavli, B., Krokan, H.E., Mosbaugh, D.W. and Tainer, J.A. (1995). Crystal Structure of Human Uracil-DNA Glycosylase in Complex with a Protein Inhibitor. Cell 82, 701-708
Kavli, B., Slupphaug, G., Mol, C.D., Arvai, A.S., Petersen, S.B., Tainer, J.A., and Krokan, H.E. (1996). Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO J. 15, 3442-3447
Slupphaug, G., Kavli, B., Mol, C.D., Arvai, A., Krokan, H.E. and Tainer, J.A. (1996). Structure of human uracil-DNA glycosylase bound to DNA shows a nucleotide flipping mechanism. Nature 384, 87-92
Nagelhus, T., Haug, T., Singh, K.K., Keshav, K.F., Skorpen, F., Bharati, S., Otterlei, M., Lindmo, T., Benichou, S., Benarous, R. and Krokan, H.E. (1997). A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34 kDa subunit of replication protein A. J. Biol. Chem. 272, 6561-6566
Krokan, H.E., Standal, R. and Slupphaug,G (1997) DNA glycosylases in base excision repair. Biochem. J. 325, 1-16
Parikh, S.S., Mol, C.D., Slupphaug, G., Bharati, S., Krokan, H.E. and Tainer, J.A. (1998). Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase. EMBO J. 17, 5214-5226
Otterlei, M., Haug, T., Nagelhus, T.A., Slupphaug, G., Lindmo, T. and Krokan, H.E. (1998). Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively. Nucl. Acids Res. 20, 4611-4617
Otterlei, M., Warbrick, E., Slupphaug, G., Nagelhus, T.A., Haug, T., Akbari, M., Aas, P.A., Steinsbekk, K., Bakke, O., and Krokan, H.E. (1999) Postreplicative Base Excision Repair in Replication Foci. EMBO J. 18, 3834-3844
Parikh, S., Walcher, G., Jones, G.D., Slupphaug, G., Krokan, H.E.,
Otterlei, M., Kavli, B., Standal, R., Skjelbred, C., Bharati, S., Krokan, H.E. (2000). Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO J. 19, 5542-5551
Kavli, B., Sundheim, O., Akbari, M., Otterlei, M., Nilsen, H., Skorpen, F., Aas, P.A., Hagen, L., Krokan, H.E. and Slupphaug, G. (2002). hUNG2 is the major repair enzyme for removal of uracil from U:A matchers, U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. J. Biol. Chem. 277, 39926-39936.
Aas, P.A., Otterlei, M., Falnes, P.Ø., Vågbø, C.B., Skorpen, F., Akbari, M., Sundheim, O., Bjørås, M., Slupphaug, G., Seeberg, E. and Krokan, H.E. (2003). Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature 421; 859-863
Imai, K, Slupphaug, G., Lee, W-I., Revy, P., Nonoyama, S, Catalan, N, Yel, L., Forveille, M., Kavli, B., Krokan, H.E., Ochs, H.D., Fischer, A. and Durandy, A. (2003) Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch. Nature Immunology 4:1023-1028
Akbari, M., Otterlei, M., Peña-Diaz, J., Kavli, B., Hagen, L., Liabakk, N.B., Imai, K., Durandy, A., Slupphaug G., and Krokan, H.E. (2004) An affinity-isolated UNG2-associated repair complex carries out complete repair of U/G mispairs and U/A pairs in DNA. Nucl. Acids Res. 32:5486-98
Kavli, B., Andersen, S., Otterlei, M., Liabakk, N., Durandy A., Imai, K., Krokan H.E., and Slupphaug, G.(2005) Lymphoid cell lines from UNG deficient HIGM patients have profoundly impaired uracil excision activity from single stranded DNA and increased levels of uracil in the chromosome. J. Exp. Med. 201, 2011-2021
Andersen, S., Ericsson, M., Dai, HY, Peña-Diaz, J., Slupphaug, G., Nilsen, H., Aarset, H. and Krokan, H.E. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair 4:1432-1441.
Auerbach, P., Bennett, A.O., Bailey, E., Krokan, H,E. and Demple, B. (2005) Mutagenic specificity of endogenously-generated abasic sites in Saccharomyces cerevisiae chromosomal DNA. Proc. Natl. Acad. Sci. USA..102:17711-17716.
Ringvoll,J., Nordstrand, L.M., Vågbø, C. B. Talstad, V., Reite,K., Aas, P.A., Lauritzen, K. H., Liabakk, N.B., Bjørk, A., Doughty, R.W., Falnes, P., Krokan, H.E. and Klungland, A. (2006) Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing endogenous and induced 1meA and 3meC lesions in DNA. EMBO J. 25:2189-2198.
Sundheim, O., Vågbø, C.V., Bjørås, de Sousa, M.M.L., Aas, P.A., Drabløs, Krokan, H.E., Tainer, J.A. and Slupphaug, G. (2006). Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO J. 25:3389-3397
Akbari, M., Otterlei, M., Peña-Diaz, J., and. Krokan, H.E. (2007) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience 6:505-516
Pettersen, H.S., Sundheim, O., Gilljam, K.; Slupphaug, G., Krokan, H.E. and Kavli, B. (2007) Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of Base Excision Repair by distinct mechanisms. Nucl. Acids. Res.35: 3879-3892.
Kavli, B., Otterlei, M., Slupphaug, G. and Krokan, H.E.(2007) DNA-General mutagen, but normal intermediate in acquired immunity. DNA Repair (Amst). 6:505-516
Hagen, L., Kavli, B., Sousa, M. M.L., Diaz, J.P., Liabakk, N.B., Aslaksen, P.B., Torseth, K., Sundheim, O., Otterlei, M., Hørning, O., Jensen, O.N., Krokan, H.E. and Slupphaug, G. (2008) Cell Cycle Regulated Phosphorylations of Human Uracil-DNA Glycosylase UNG2 Govern Replication-Associated Uracil Removal EMBO J. 27:51-61
Akbari, M., Visnes, T., Krokan, H.E. and Otterlei, M. (2008) Base excision repair by human mitochondrial extracts involves both single-nucleotide insertion and long-patch DNA synthesis. DNA Repair 7:605-616
Hung, R.J., McKay, J.D., Gaborieau, V., Boffetta, P., Hashibe, M., Earidze, D., …Krokan, H.E.,… Lathrop, M., Brennan, P. (2008) A genome-wide association study identifies a susceptibility locus for lung cancer encompassing nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452:633-637(multicenter study with 6 centers, several author names deleted to save space)
Westbye, M.P., Feyzi, E., Aas, P.A., Vågbø, C.B., Kavli, B., Talstad, V.A., Hagen, L., Sundheim, O., Liabakk, N-B., Slupphaug, G., Otterlei, M., Krokan, H.E.(2008) Human AlkB homologue 1 is a mitochondrial protein that repairs 3-methylcytosine in DNA. J Biol Chem 283:25046-25056
McKay, J.D., Hung, R.J. , Gaborieau, V., Boffetta, P., (authors deleted), Krokan, H.E., Skorpen, F., Elvestad, M.B., Vatten, L.,…(authors deleted) Lathrop, M., Brennan, P. (2008) Identification of gene region 5p15.33, comprising the telomerase reverse transcriptase gene, as a novel lung cancer susceptibility locus among 6,000 lung cancer cases and 9,500 controls. Nature Genetics 40:1404-1406 (multicenter study with 6 centers, several author names deleted to save space)
Sundheim, O., Talstad, V.A., Vågbø, C.B., Slupphaug, G., Krokan, H.E. (2008) AlkB demethylases flip out in different ways. DNA Repair 7:1916-1923
Visnes, T., Doseth, B., Pettersen, H.S.,
Publikasjoner
2023
-
Lefol, Yohan Pierre;
Korfage, Tom;
Mjelle, Robin;
Prebensen, Christian Haugland;
Lüders, Torben;
Müller, Bruno.
(2023)
TiSA: TimeSeriesAnalysis - A pipeline for the analysis of longitudinal transcriptomics data.
NAR Genomics and Bioinformatics
Vitenskapelig artikkel
2022
-
Bonagas, Nadilly;
Gustafsson, Nina M. S.;
Henriksson, Martin;
Marttila, Petra;
Gustafsson, Robert;
Wiita, Elisée.
(2022)
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nature Cancer
Vitenskapelig artikkel
2021
-
Olinski, Ryszard;
Slupphaug, Geir;
Foksinski, Marek;
Krokan, Hans Einar.
(2021)
Genomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignancies.
International Journal of Molecular Sciences
Vitenskapelig artikkel
2020
-
Visnes, Torkild;
Benitez-Buelga, Carlos;
Cázares-Körner, Armando;
Sanjiv, Kumar;
Hanna, Bishoy M F;
Mortusewicz, Oliver.
(2020)
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Boeckemeier, L;
Kraehenbuehl, R;
Keszthelyi, A;
Gasasira, MU;
Vernon, EG;
Beardmore, R.
(2020)
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.
Science Advances
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2020)
Genomic Uracil in Biology, Immunity and Cancer.
Royal Society of Chemistry (RSC) Publishing
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
2019
-
Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2018
-
Slupphaug, Geir;
Krokan, Hans Einar.
(2018)
Genomic Uracil – Valuable Tool in Molecular Biology but Inherent Problem in Sequencing of Ancient DNA.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Viral Uracil - Uracil DNA glycosylases and dUTPases.
World Scientific
Faglig kapittel
-
Slupphaug, Geir;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2018)
Routes to Uracil in DNA.
World Scientific
Faglig kapittel
-
Slupphaug, Geir;
Krokan, Hans Einar.
(2018)
Genomic Uracil - Evolution, Biology, Immunology and Disease.
World Scientific
World Scientific
Fagbok
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Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
DNA Repair is Integrated with Many Cellular Processes.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Sarno, Antonio;
Slupphaug, Geir.
(2018)
Enzymology of Genomic Uracil Repair.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir;
Drabløs, Finn.
(2018)
The Earth, Life and Genomic Uracil.
World Scientific
Faglig kapittel
-
Visnes, Torkild;
Armando, Cazares-Körner;
Wenjing, Hao;
Wallner, Olov;
Masuyer, Geoffrey;
Loseva, Olga.
(2018)
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Science
Vitenskapelig artikkel
2017
-
Wang, Yufei;
McKay, James D.;
Rafnar, Thorunn;
Wang, Zhaoming;
Timofeeva, Maria N.;
Broderick, Peter.
(2017)
Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer (Nature Genetics (2014) 46 (736-741)).
Nature Genetics
Errata
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Krokan, Hans Einar;
Slupphaug, Geir;
Kavli, Bodil Merete.
(2017)
Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Alsøe, Lene;
Sarno, Antonio;
Carracedo Huroz, Sergio;
Domanska, Diana Ewa;
Dingler, Felix;
Lirussi, Lisa.
(2017)
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Scientific Reports
Vitenskapelig artikkel
2016
-
Rasmussen, Erik;
Vågbø, Cathrine Broberg;
Münch, Daniel;
Krokan, Hans Einar;
Klungland, Arne;
Amdam, Gro Vang.
(2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.
Biochemistry and Biophysics Reports
Vitenskapelig artikkel
-
Robles, Ana I.;
Olsen, Karina Standahl;
Tsui, Dana W.T.;
Georgoulias, Vassilis;
Creaney, Jenette;
Dobra, Katalin.
(2016)
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Xue, JH;
Xu, GF;
Gu, TP;
Chen, GD;
Han, BB;
Xu, ZM.
(2016)
Uracil-DNA glycosylase UNG promotes tet-mediated DNA demethylation.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Helander, Linda;
Sharma, Animesh;
Krokan, Hans Einar;
Plaetzer, Kristjan;
Krammer, Barbara;
Tortik, Nicole.
(2016)
Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins.
Molecular Biosystems
Vitenskapelig artikkel
2015
-
Helander, Linda;
Krokan, Hans Einar;
Gederaas, Odrun Arna;
Johnsson, Anders Carl G.;
Chen, Duan.
(2015)
Hexylaminolevulinate Photodynamic Treatment of Cancer Cell Lines. PhD Thesis.
Tapir Akademisk Forlag
Tapir Akademisk Forlag
Doktorgradsavhandling
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
-
Brenner, Darren. R.;
Amos, Christopher I.;
Brhane, Yonathan;
Timofeeva, Maria N.;
Caporaso, Neil;
Wang, Yufei.
(2015)
Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia.
Carcinogenesis
Vitenskapelig artikkel
-
Mjelle, Robin;
Hegre, Siv Anita;
Aas, Per Arne;
Slupphaug, Geir;
Drabløs, Finn;
Sætrom, Pål.
(2015)
Cell cycle regulation of human DNA repair and chromatin remodeling genes.
DNA Repair
Vitenskapelig artikkel
2014
-
Wang, Yufei;
McKay, JD;
Rafnar, T;
Wang, Z;
Timofeeva, MN;
Broderick, P.
(2014)
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
Nature Genetics
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Vitenskapelig artikkel
-
Hu, Yi;
Ericsson, Ida;
Doseth, Berit;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2014)
Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors.
Experimental Cell Research
Vitenskapelig artikkel
-
Wallenius, Anders;
Hauser, Jannek;
Aas, Per Arne;
Sarno, Antonio;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2014)
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Molecular Immunology
Vitenskapelig artikkel
-
Zdzalik, Daria;
Vågbø, Cathrine Broberg;
Kirpekar, F;
Davydova, Erna;
Puścian, Alicja;
Maciejewska, Agnieszka M..
(2014)
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities.
PLOS ONE
Vitenskapelig artikkel
-
Helander, Linda;
Krokan, Hans Einar;
Johnsson, Anders Carl G.;
Gederaas, Odrun Arna;
Plaetzer, Kristjan.
(2014)
Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro.
Journal of Biomedical Optics
Vitenskapelig artikkel
2013
-
Bjørngaard, Johan Håkon;
Gunnell, David;
Gabrielsen, Maiken Elvestad;
Davey Smith, George;
Skorpen, Frank;
Krokan, Hans Einar.
(2013)
The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study.
Psychological Medicine
Vitenskapelig artikkel
-
Overland, Hilde Bremseth;
Schønberg, Svanhild Margrethe Arentz;
Krokan, Hans Einar.
(2013)
ER stress, reactive oxygen species and autophagy in colon cancer cells treated with polyunsaturated marine fatty acids.
Doktoravhandlinger ved NTNU (1)
Doktorgradsavhandling
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Ericsson, Ida;
Galashevskaya, Anastasia;
Sarno, Antonio;
Aas, Per Arne.
(2013)
Genomic uracil - potent mutagen but normal intermediate in adaptive immunity.
The FEBS Journal
Sammendrag/abstract
-
Hu, Yi;
Ericsson, Ida;
Torseth, Kathrin;
Methot, Stephen;
Sundheim, Ottar;
Liabakk, Nina-Beate.
(2013)
A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.
Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
-
Zheng, Guanqun;
Dahl, John Arne;
Niu, Yamei;
Fedorcsak, Peter;
Huang, Chun-Min;
Li, Charles J..
(2013)
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility.
Molecular Cell
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Bjørås, Magnar.
(2013)
Base Excision Repair.
Cold Spring Harbor Perspectives in Biology
Vitenskapelig artikkel
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Vitenskapelig artikkel
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Vitenskapelig artikkel
-
Diaz, Javier Pena;
Hegre, Siv Anita;
Anderssen, Endre;
Aas, Per Arne;
Mjelle, Robin;
Gilfillan, Gregor Duncan.
(2013)
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Gabrielsen, Maiken Elvestad;
Romundstad, Pål Richard;
Langhammer, Arnulf;
Krokan, Hans Einar;
Skorpen, Frank.
(2013)
Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway.
European Journal of Human Genetics
Vitenskapelig artikkel
2012
-
Krokan, Hans Einar.
(2012)
A life in DNA repair-And beyond.
DNA Repair
Leder
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Vitenskapelig artikkel
-
Doseth, Berit;
Ekre, Cecilie;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2012)
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2012)
To Repair and Protect.
International Innovation
Populærvitenskapelig artikkel
-
Krokan, Hans Einar.
(2012)
Stable Genomes and DNA Repair.
International Innovation
Populærvitenskapelig artikkel
-
Krokan, Hans Einar.
(2012)
The Essentials of DNA Repair.
Public Service Review: European Union
Populærvitenskapelig artikkel
-
Timofeeva, MN;
Hung, RJ;
Rafnar, T;
Christiani, DC;
Field, JK;
Bickeboller, H.
(2012)
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
Human Molecular Genetics
Vitenskapelig artikkel
-
Meza, Trine Johansen;
Moen, Marivi;
Vågbø, Cathrine Broberg;
Krokan, Hans Einar;
Klungland, Arne;
Grini, Paul Eivind.
(2012)
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Akbari, Mansour;
Krokan, Hans Einar.
(2012)
Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-Implications for comparative studies.
Mutation research
Vitenskapelig artikkel
-
Kazma, R;
Babron, MC;
Gaborieau, Valerie;
Génin, E;
Brennan, P;
Hung, Rayjean J..
(2012)
Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium.
Carcinogenesis
Vitenskapelig artikkel
-
Johnson, Matthew P;
Brennecke, Shaun P.;
Iversen, Ann-Charlotte;
East, Christine;
Olsen, Guro Dalheim;
Kent, Jack W.
(2012)
Genome-wide association scans identify novel maternal susceptibility loci for preeclampsia.
Pregnancy Hypertension
Sammendrag/abstract
2011
-
Robertson, Adam Brian;
Dahl, John Arne;
Vågbø, Cathrine Broberg;
Tripathi, P;
Krokan, Hans Einar;
Klungland, Arne.
(2011)
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Arum, Carl-Jørgen;
Gederaas, Odrun Arna;
Larsen, Eivind La Puebla;
Randeberg, Lise Lyngsnes;
Hjelde, Astrid;
Krokan, Hans Einar.
(2011)
Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action.
Journal of Biomedical Optics
Vitenskapelig artikkel
-
Leihne, VIbeke;
Kirpekar, F;
Vågbø, Cathrine Broberg;
Van den Born, Erwin;
Krokan, Hans Einar;
Grini, Paul Eivind.
(2011)
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Sundheim, Ottar;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2011)
XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage.
Environmental and Molecular Mutagenesis
Vitenskapelig artikkel
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods
Vitenskapelig artikkel
-
Doseth, Berit;
Visnes, Torkild;
Wallenius, Anders;
Ericsson, Ida;
Sarno, Antonio;
Pettersen, Henrik Sahlin.
(2011)
Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Van den Born, Erwin;
Vågbø, Cathrine Broberg;
Songe-Møller, Lene;
Leihne, VIbeke;
Lien, Guro Flor;
Leszczynska, G.
(2011)
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nature Communications
Vitenskapelig artikkel
-
Baglo, Yan;
Sousa, Mirta;
Slupphaug, Geir;
Hagen, Lars;
Håvåg, Sissel;
Helander, Linda.
(2011)
Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways.
Photochemical and Photobiological Sciences
Vitenskapelig artikkel
2010
-
Monsen, Vivi A Talstad;
Sundheim, Ottar;
Aas, Per Arne;
Westbye, Marianne Pedersen;
Sousa, Mirta;
Slupphaug, Geir.
(2010)
Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2010)
Advarer mot biodiesel i fossilt diesel: Svært mange kan bli syke.
Teknisk Ukeblad
Intervju tidsskrift
-
Monsen, Vivi A Talstad;
Krokan, Hans Einar;
Aas, Per Arne.
(2010)
Mechanisms of alkylation damage repair by human AlkB homologues.
NTNU
Doktorgradsavhandling
-
Songe-Møller, Lene;
Van den Born, Erwin;
Leihne, V;
Vågbø, Cathrine Broberg;
Kristoffersen, T;
Krokan, Hans Einar.
(2010)
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding.
Molecular and Cellular Biology
Vitenskapelig artikkel
-
Slagsvold, Jens Erik;
Pettersen, Caroline Hild;
Størvold, Gro Leite;
Follestad, Turid;
Krokan, Hans Einar;
Schønberg, Svanhild Margrethe Arentz.
(2010)
DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells.
Nutrition and Cancer
Vitenskapelig artikkel
-
Akbari, Mansour;
Solvang-Garten, Karin;
Hanssen-Bauer, Audun;
Lieske, Nora V.;
Pettersen, Henrik P Sahlin;
Pettersen, Grete Klippenvåg.
(2010)
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Sammendrag/abstract
2009
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel/review
-
Slagsvold, Jens Erik;
Pettersen, Caroline Hild;
Follestad, Turid;
Krokan, Hans Einar;
Schønberg, Svanhild Margrethe Arentz.
(2009)
The Antiproliferative Effect of EPA in HL60 Cells is Mediated by Alterations in Calcium Homeostasis.
Lipids
Vitenskapelig artikkel
-
Størvold, Gro Leite;
Fleten, Karianne Giller;
Olsen, Cathrine Goberg;
Follestad, Turid;
Krokan, Hans Einar;
Schønberg, Svanhild Margrethe Arentz.
(2009)
Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells.
Lipids
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
-
Akbari, Mansour;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Liabakk, Nina-Beate;
Otterlei, Marit;
Krokan, Hans Einar.
(2009)
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.
DNA Repair
Vitenskapelig artikkel
-
Aas, Per Arne;
Diaz, Javier Pena;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Skorpen, Frank.
(2009)
Overexpression of transcription factor AP-2 stimulates the P-A promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Visnes, Torkild.
(2009)
DNA Excision repair of uracil and 5-fluorouracil in human cancer cell lines.
Det medisinske fakultet, NTNU
Doktorgradsavhandling
-
Landi, MT;
Chatterjee, N;
Yu, K;
Goldin, LR;
Goldstein, AM;
Rotunno, M.
(2009)
A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma.
American Journal of Human Genetics
Vitenskapelig artikkel
2008
-
Hung, RJ;
Mckay, J;
Gaborieau, V;
Boffetta, P;
Chu, C;
Field, JK.
(2008)
Detecting new genes for tobacco-related cancers - genomewide association study of lung cancer.
European Journal of Cancer
Sammendrag/abstract
-
Akbari, Mansour;
Krokan, Hans Einar.
(2008)
Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging.
Mechanisms of Ageing and Development
Vitenskapelig oversiktsartikkel/review
-
Andersen, Sonja Benedikte;
Krokan, Hans Einar;
Baar, Cecilie Christensen;
Rakvag, Trude Teoline;
Laugsand, Eivor Alette;
Kvam, Tor-Morten.
(2008)
Identification of an alternative, putative promoter and new alternatively spliced transcripts from the human µ opioid receptor gene, OPRM1.
Palliative Medicine
Sammendrag/abstract
-
Heath, SC;
Gut, IG;
Brennan, P;
Mckay, JD;
Bencko, V;
Fabianova, E.
(2008)
Investigation of the fine structure of European populations with applications to disease association studies.
European Journal of Human Genetics
Vitenskapelig artikkel
-
McKay, JD;
Mckay, JD;
Hung, RJ;
Gaborieau, V;
Boffetta, Paolo;
Chabrier, Amelie.
(2008)
Lung cancer susceptibility locus at 5p15.33.
Nature Genetics
Vitenskapelig artikkel
-
Slagsvold, Jens Erik;
Pettersen, Caroline Hild;
Follestad, Turid;
Krokan, Hans Einar;
Schønberg, Svanhild Margrethe Arentz.
(2008)
The antiproliferative effect of EPA in HL60 cells is mediated by alterations in calcium homeostasis.
Lipids
Vitenskapelig artikkel
-
Hung, RJ;
Mckay, JD;
Gaborieau, V;
Boffetta, P;
Hashibe, M;
Zaridze, D.
(2008)
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
Nature
Vitenskapelig artikkel
-
Bathen, Tone Frost;
Holmgren, Kristin;
Lundemo, Anne Gøril;
Hjelstuen, Mari H;
Krokan, Hans Einar;
Gribbestad, Ingrid S.
(2008)
Omega-3 Fatty Acids Supress Growth of SW620 Human Colon Cancer Xenografts in Nude Mice.
Anticancer Research
Vitenskapelig artikkel
-
Akbari, Mansour;
Visnes, Torkild;
Krokan, Hans Einar;
Otterlei, Marit.
(2008)
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
DNA Repair
Vitenskapelig artikkel
-
Sundheim, Ottar;
Talstad, Vivi A;
Vågbø, Cathrine Broberg;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
AlkB demethylases flip out in different ways.
DNA Repair
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Visnes, Torkild;
Akbari, Mansour;
Hagen, Lars;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
The rate of base excision repair of uracil is controlled by the initiating glycosylase.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2008)
NBS 40 år.
NBS-nytt
Populærvitenskapelig artikkel
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
-
Jakobsen, CH;
Pettersen, Caroline Hild;
Størvold, Gro Leite;
Bremseth, Hilde;
Follestad, Turid;
Sand, Kristin.
(2008)
DHA induces ER stress and growth arrest in human colon cancer cells: association with cholesterol and calcium homeostasis.
Journal of Lipid Research
Vitenskapelig artikkel
-
Larsen, Eivind La Puebla;
Randeberg, Lise Lyngsnes;
Gederaas, Odrun Arna;
Arum, Carl-Jørgen;
Hjelde, Astrid;
Zhao, Chun-Mei.
(2008)
Monitoring of Hexyl 5-aminolevulinate Induced Photodynamic Therapy in Rat Bladder Cancer by Optical Spectroscopy.
Journal of Biomedical Optics
Vitenskapelig artikkel
2007
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2007)
Repair of small base lesions in DNA - From molecular biology to phenotype - Preface.
DNA Repair
Leder
-
Sousa, Mirta;
Krokan, Hans Einar;
Slupphaug, Geir.
(2007)
DNA-uracil and human pathology.
Molecular Aspects of Medicine
Vitenskapelig oversiktsartikkel/review
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2007)
Repair of small base lesions in DNA- from molecular biology to phenotype.
DNA Repair
Sammendrag/abstract
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Sammendrag/abstract
-
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Gilljam, Karin Margaretha;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2007)
Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Vitenskapelig artikkel
-
Larsen, Eivind La Puebla;
Randeberg, Lise Lyngsnes;
Gederaas, Odrun Arna;
Krokan, Hans Einar;
Hjelme, Dag Roar;
Svaasand, Lars O..
(2007)
In vitro study on methemoglobin formation in erythrocytes following hexyl-aminolevulinate induced photodynamic therapy.
SPIE - The International Society for Optics and Photonics
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Akbari, Mansour;
Otterlei, Marit;
Pena-Diaz, J;
Krokan, Hans Einar.
(2007)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Vitenskapelig artikkel
2006
-
Larsen, Eivind La Puebla;
Randeberg, Lise Lyngsnes;
Gederaas, Odrun Arna;
Arum, Carl-Jørgen;
Krokan, Hans Einar;
Chen, Duan.
(2006)
Monitoring of hALA induced PDT in rat bladder cancer by optical spectroscopy.
Lasers in Surgery and Medicine
Sammendrag/abstract
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Vitenskapelig oversiktsartikkel/review
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Sammendrag/abstract
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Vitenskapelig artikkel
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Krokan, Hans Einar.
(2006)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2006)
Preface.
DNA Repair
Vitenskapelig artikkel
-
Schønberg, Svanhild Margrethe Arentz;
Lundemo, Anne Gøril;
Fladvad, Torill;
Holmgren, Kristin;
Bremseth, Hilde;
Nilsen, Asbjørn Magne.
(2006)
Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1.
The FEBS Journal
Vitenskapelig artikkel
2005
-
Hjelde, Astrid;
Gederaas, Odrun Arna;
Krokan, Hans Einar;
Brubakk, Alf O.
(2005)
Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines.
Medical Science Monitor
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
-
Gederaas, Odrun Arna;
Schønberg, Svanhild Margrethe Arentz;
Ramstad, Ståle;
Berg, Kristian;
Johnsson, Anders Carl G.;
Krokan, Hans Einar.
(2005)
Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization.
Photochemical and Photobiological Sciences
Vitenskapelig artikkel
-
Andersen, Sonja Benedikte;
Heine, T;
Sneve, Ragnhild;
Kønig, Imbritt;
Krokan, Hans Einar;
Epe, B.
(2005)
Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.
Carcinogenesis
Vitenskapelig artikkel
-
Andersen, Sonja Benedikte;
Ericsson, Maria Elisabeth Madelene;
Dai, HY;
Diaz, Javier Pena;
Slupphaug, Geir;
Nilsen, H.
(2005)
Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice.
DNA Repair
Vitenskapelig artikkel
-
Auerbach, Paul;
Bennett, Richard A.O.;
Bailey, Elisabeth A.;
Krokan, Hans Einar;
Demple, Bruce.
(2005)
Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
-
Schønberg, Svanhild Margrethe Arentz;
Jakobsen, Caroline Hild;
Bremseth, Hilde;
Olsen, Karina Standahl;
Lundemo, Anne Gøril;
Follestad, Turid.
(2005)
Endoplasmic reticulum stress induced by DHA leads to growth arrest of human colon cancer cells.
Chemistry and Physics of Lipids
Vitenskapelig artikkel
-
Akbari, Mansour;
Hansen, Marianne Dore;
Halgunset, Jostein;
Skorpen, Frank;
Krokan, Hans Einar.
(2005)
Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner.
Journal of Molecular Diagnostics
Vitenskapelig artikkel
-
Rakvag, Trude Teoline;
Klepstad, Pål;
Baar, Cecilie Christensen;
Kvam, Tor-Morten;
Dale, Ola;
Kaasa, Stein.
(2005)
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients.
Pain
Vitenskapelig artikkel
-
Andersen, S;
Heine, T;
Sneve, Ragnhild;
Konig, I;
Krokan, HE;
Epe, B.
(2005)
Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.
Carcinogenesis
Vitenskapelig artikkel
-
Andersen, S;
Ericsson, M;
DAI, H;
Peña-Diaz, J;
Slupphaug, G;
Nilsen, Hilde.
(2005)
Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice.
DNA Repair
Vitenskapelig artikkel
2004
-
Krokan, Hans Einar.
(2004)
Molecular and functional interactions in macromolecular repair.
European Journal of Biochemistry (EJB)
Sammendrag/abstract
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2004)
Novel aspects of macromolecular repair and relationship to human disease.
Journal of Molecular Medicine
Vitenskapelig oversiktsartikkel/review
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
-
Kvam, TM;
Baar, Cecilie Christensen;
Raakvag, Trude Teoline;
Kaasa, Stein;
Krokan, Hans Einar;
Skorpen, Frank.
(2004)
Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing.
Journal of Molecular Medicine
Vitenskapelig artikkel
-
Klepstad, Pål;
Rakvag, TT;
Kaasa, Stein;
Holthe, Monica;
Dale, Ola;
Borchgrevink, Petter Chr..
(2004)
The 118 A>G polymorphism in the human mu-opioid receptor gene may increase morphins requirements in patients with pain caused by malignant disease.
Acta Anaesthesiologica Scandinavica
Vitenskapelig artikkel
-
Akbari, Mansour;
Skjelbred, C;
Folling, I;
Sagen, J;
Krokan, Hans Einar.
(2004)
A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss.
Scandinavian Journal of Clinical and Laboratory Investigation
Vitenskapelig artikkel
-
Diaz, Javier Pena;
Akbari, Mansour;
Sundheim, Ottar;
Farez-Vidal, ME;
Andersen, S;
Sneve, R.
(2004)
Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.
Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Akbari, M;
Skjelbred, C;
Folling, I;
Sagen, Jørn V.;
Krokan, HE.
(2004)
A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA (Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss.
Scandinavian Journal of Clinical and Laboratory Investigation
Vitenskapelig artikkel
-
Klepstad, Pål;
Rakvag, Trude Teoline;
Kaasa, Stein;
Holthe, Monica;
Dale, Ola;
Borchgrevink, Petter Chr..
(2004)
The 118 A>G polymorphism in the human µ-opioidreceptor gene may increase morphine requrements in patients with pain caused by malignant disease.
Acta Anaesthesiologica Scandinavica
Vitenskapelig artikkel
-
Akbari, M;
Skjelbred, C;
Følling, Ivar;
Sagen, J;
Krokan, H E.
(2004)
A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA Leu (UUR)) applied to a Norwegian family with diabetes mellitus and hearing loss.
Scandinavian Journal of Clinical and Laboratory Investigation
Vitenskapelig artikkel
2003
-
Holthe, M.;
Rakvåg, Trude Teoline;
Klepstad, Pål;
Idle, Jefrrey R.;
Kaasa, Stein;
Krokan, Hans Einar.
(2003)
Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients.
The Pharmacogenomics Journal
Vitenskapelig artikkel
-
Slupphaug, Geir;
Kavli, Bodil;
Krokan, Hans Einar.
(2003)
Interacting pathways that prevent and repair oxidative DNA damage.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Nilsen, Hilde;
Stamp, G;
Andersen, Sonja;
Hrivnak, G;
Krokan, Hans Einar;
Lindahl, T.
(2003)
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.
Oncogene
Vitenskapelig artikkel
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
-
Imai, K;
Slupphaug, Geir;
Lee, W-I;
Revy, P;
Nonoyama, S;
Catalan, N.
(2003)
Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch.
Nature Immunology
Vitenskapelig artikkel
-
Holthe, Monica;
Råkvåg, Trude Teoline;
Klepstad, Pål;
Idle, Jefrrey R.;
Kaasa, Stein;
Krokan, Hans Einar.
(2003)
Identification of 10 novel single nucleotide polymorphisms and analysis of their relevance to morphine glucuronidation.
The Pharmacogenomics Journal
Vitenskapelig artikkel
2002
-
Holthe, Monica;
Klepstad, Pål;
Zahlsen, Kolbjørn;
Borchgrevink, Petter Chr.;
Hagen, Lars;
Dale, Ola.
(2002)
Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1a1*28 polymorphisms in cancer patients on chronic morphine therapy.
European Journal of Clinical Pharmacology
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Drabløs, Finn;
Slupphaug, Geir.
(2002)
Uracil in DNA, occurrence, consequences and repair.
Oncogene
Vitenskapelig artikkel
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2002)
Fromprotein folding to new enzymes.
Tidsskrift for Den norske legeforening
Vitenskapelig artikkel
-
Holthe, Monica;
Råkvåg, Trude Teoline;
Klepstad, Pål;
Idle, Jefrrey R.;
Kaasa, Stein;
Krokan, Hans Einar.
(2002)
Sequence variationin the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphins (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients.
The Pharmacogenomics Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2002)
Damage and repair of DNA in mammalian cells-emphasis on oxidative damage. Proceedings from International Symposium "Natural Ionising Radiation and Health".
Det Norske Videnskaps-Akademi : proceedings
Vitenskapelig artikkel
-
Grøsvik, K;
Slupphaug, Geir;
Krokan, Hans Einar.
(2002)
"Characterisation of uracil-exising enzyme activities in organ extracts from UNG knockout and wild-type mice.".
NTNU
Hovedfagsoppgave
-
Nygård, M;
Nilsen, M;
Remseth, V;
Slupphaug, Geir;
Krokan, Hans Einar.
(2002)
Uttrykk av det membran-modifiserende enzymet UDPDG i E.coli som funksjon av dyrkningsbetingelser og induksjon av DNA-skader.
[Mangler utgivernavn]
Hovedfagsoppgave
2001
-
Krokan, Hans Einar;
Nilsen, Hilde.
(2001)
Base excision repair in a network of defence and tolerance.
Carcinogenesis
Vitenskapelig artikkel
-
Rudra, Parveen;
Krokan, Hans Einar.
(2001)
Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid.
Anticancer Research
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Prydz, H..
(2001)
Genoverføring - administrasjonsmåter, fordeler, mulige ulemper og farer.
Tidsskrift for Den norske legeforening
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
-
Dusseau, C.;
Murray, GI;
Keenan, RA;
OKelly, T.;
Krokan, Hans Einar;
McLeod, HL.
(2001)
Analysis of uracil DNA glycosylase in human colorectal cancer.
International Journal of Oncology
Vitenskapelig artikkel
-
Kvaløy, Kirsti;
Nilsen, H.;
Steinsbekk, Kristin;
Nedal, Aina;
Monterotti, Bruno;
Akbari, Mansour.
(2001)
Sequence variation in the human uracil-DNA glycosylase (UNG) gene.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Prydz, H..
(2001)
Genoverføring - administrasjonsmåter, fordeler, mulige ulemper og farer.
Tidsskrift for Den norske legeforening
Vitenskapelig artikkel
-
Prydz, Hans Peter B;
Krokan, Hans E..
(2001)
Genoverføring - Administrasjonsmåter, fordeler, mulige ulemper og farer.
TDNLF
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2001)
Kong Olav V's kreftforskningspris til Erling Seeberg.
NBS-nytt
Populærvitenskapelig artikkel
-
Krokan, Hans Einar.
(2001)
Biologiens århundre er nå.
Fondsfinans Farmasi - Bioteknologi, Årsrapport 2000
Populærvitenskapelig artikkel
2000
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Parikh, Sudip S.;
Walcher, Gunter;
Jones, Garry D.;
Slupphaug, Geir;
Krokan, Hans Einar;
Blackburn, G.Michael.
(2000)
Uracil-DNA glycosylase-DNA substrate and product structures:Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, Hilde;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair of DNA in mammalian cells.
FEBS Letters
Vitenskapelig artikkel
-
Nilsen, Hilde;
Rosewell, Ian;
Robins, Peter;
Skjelbred, Camilla;
Andersen, Sonja;
Slupphaug, Geir.
(2000)
URACIL-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication.
Molecular Cell
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, H.;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair in mammalian cells.
FEBS Letters
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Parikh, S;
Walcher, G;
Jones, G.D;
Slupphaug, Geir;
Krokan, Hans Einar;
Blackburn, G.M.
(2000)
Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
-
Nilsen, Hilde;
Rosewell, I.;
Robins, P.;
Skjelbred, Camilla;
Andersen, Sonja;
Slupphaug, Geir.
(2000)
) Ung-deficient mice reveal a primary role of the uracil-DNA glycosylase enzyme during DNA replication.
Molecular Cell
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Smeland, Erlend;
Prydz, Hans;
Ørstadvik, Karen Helene;
Frøland, Stig;
Aamdal, Steinar;
Myklebost, Ola.
(2000)
Genterapi Status og fremtidige muligheter innen klinisk medisin.
Lobo Grafisk AS
Fagbok
-
Smeland, Erlend B;
Prydz, Hans Peter B;
Ørstavik, Karen Helene;
Frøland, Stig Sophus;
Aamdal, Steinar;
Myklebost, Ola.
(2000)
Genterapi. Status og fremtidige muligheter innen klinisk medisin.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
1999
-
Krokan, Hans Einar;
Schønberg, Svanhild.
(1999)
Norsk studie visar att fettsyror från fisk kan døda cancerceller.
Landstidningen, Sverige
Kronikk
-
Krokan, Hans Einar;
Schønberg, Svanhild.
(1999)
Omega 3 fettsyrer.
Østersundsposten
Kronikk
-
Schønberg, Svanhild;
Krokan, Hans Einar.
(1999)
Fisk tar knekken på kreftceller.
Adresseavisen
Kronikk
-
Waldum, Helge;
Sandvik, AK;
Angelsen, Anders;
Krokan, Hans Einar;
Falkmer, Sture Emil.
(1999)
The origin of gut and pancreatic neuroendocrine (APUD) cells - the last word?.
Journal of Pathology
Kronikk
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
-
Waldum, Helge;
Sandvik, AK;
Angelsen, Anders;
Krokan, Hans Einar;
Falkmer, S.
(1999)
Re. Editorial entitled "The origin of gut and pancreatic neuroendocrine (APUD) cells-the last word?".
Journal of Pathology
Vitenskapelig artikkel
-
Rudra, Parveen K.;
Krokan, Hans Einar.
(1999)
Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells.
Anticancer Research
Vitenskapelig artikkel
-
Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal
Vitenskapelig artikkel
-
Waldum, Helge;
Sandvik, AK;
Angelsen, Anders;
Krokan, Hans Einar.
(1999)
The origin of gut and pancreatic neuroendocrine cells - the last word?.
Journal of Pathology
Vitenskapelig artikkel
-
Waldum, Helge;
Sandvik, Arne Kristian;
Angelsen, Anders;
Krokan, Hans Einar;
Falkmer, Sture Emil.
(1999)
Letter to the Editor: Re. Editorial entitled "The origin of gut and pancreatic neuroendocrine (APUD) cells - the last word?".
Journal of Pathology
Vitenskapelig artikkel
-
Schønberg, Svanhild;
Krokan, Hans Einar.
(1999)
Fisk tar knekken på kreftceller.
Aftenposten (morgenutg. : trykt utg.)
Populærvitenskapelig artikkel
-
Krokan, Hans Einar;
Schønberg, Svanhild;
Rudra, Parveen Kumar.
(1999)
Dreper kreft : sporet etter de krefthemmende mekanismene i Omega-3 (n-3fettsyrer) er blitt sterkere.
Teknisk Ukeblad
Populærvitenskapelig artikkel
-
Krokan, Hans Einar.
(1999)
Kapittel 16: Vann og elektrolytter.
Cappelen Damm Høyskoleforlaget
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
1998
-
Skorpen, Frank;
Alm, B.;
Skjelbred, Camilla;
Aas, P.A.;
Krokan, Hans Einar.
(1998)
Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells.
Chemico-Biological Interactions
Vitenskapelig artikkel
-
Haug, T.;
Skorpen, Frank;
Aas, P.A.;
Malm, V;
Skjelbred, Camilla;
Krokan, Hans Einar.
(1998)
Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Bharati, S.;
Krokan, Hans Einar;
Kristiansen, L;
Otterlei, Marit;
Slupphaug, Geir.
(1998)
Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Parikh, S.S.;
Slupphaug, Geir;
Bharati, S;
Trainer, J.A..
(1998)
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
EMBO Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Slupphaug, Geir.
(1998)
DNA-reparasjonsenzymer og deres gener.
Tidsskrift for Den norske legeforening
Vitenskapelig artikkel
-
Otterlei, Marit;
Haug, T.;
Nagelhus, T.A;
Slupphaug, Geir;
Lindmo, T.;
Krokan, Hans Einar.
(1998)
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Parikh, S. Sudip;
Mol, Clifford D.;
Slupphaug, Geir;
Bharati, Sangeta;
Krokan, Hans Einar;
Yainer, John A..
(1998)
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Skorpen, Frank;
Skjelbred, Camilla;
Aas, P.A.;
Alm, B.;
Schønberg, S.A.;
Krokan, Hans Einar.
(1998)
Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Nøding, R.;
Schønberg, S.A.;
Krokan, Hans Einar;
Bjerve, K.S..
(1998)
Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media.
Lipids
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences.
Fagbok
1997
-
Nilsen, H.;
Otterlei, Marit;
Haug, T.;
Solum, K.;
Nagelhus, T.A;
Skorpen, Frank.
(1997)
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Nagelhus, T.;
Haug, T.;
Singh, K.K.;
Keshav, K.F.;
Skorpen, Frank;
Bharati, S..
(1997)
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Schønberg, S.M.;
Rudra, P.K.;
Nøding, R.;
Bjerve, K.S;
Krokan, Hans Einar.
(1997)
Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids.
Carcinogenesis
Vitenskapelig artikkel
-
Schønberg, Svanhild A.;
Rudra, Parveen K.;
Nøding, Randi;
Skorpen, Frank;
Bjerve, Kristian S;
Krokan, Hans Einar.
(1997)
Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids.
Carcinogenesis
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Standal, Rune;
Slupphaug, Geir.
(1997)
DNA glycosylase in the base excision repair of DNA.
Biochemical Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Standal, Rune;
Bharati, Sangeeta;
Otterlei, Marit;
Haug, Terje;
Slupphaug, Geir.
(1997)
Uracil in DNA and the family of concerved uracil DNA glycosylases.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
1996
-
Dizdaroglu, M.;
Karakaya, A.;
Jaruga, P.;
Slupphaug, Geir;
Krokan, Hans Einar.
(1996)
Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Slupphaug, Geir;
Kavli, B.;
Mol, C.D.;
Arvai, A.;
Krokan, Hans Einar;
Tainer, J.A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Kavli, B.;
Slupphaug, Geir;
Mol, C.D.;
Arvai, A.S.;
Petersen, S.B.;
Tainer, J.A..
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Kavli, Bodil;
Slupphaug, Geir;
Mol, Clifford D.;
Arvai, Andrew S.;
Petersen, Steffen B.;
Tainer, John A..
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Haug, Terje;
Skorpen, Frank;
Kvaløy, Kirsti;
Eftedal, Ingrid;
Lund, Henning;
Krokan, Hans Einar.
(1996)
Human uracil-DNA glycosylase gene : sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1.
Genomics
Vitenskapelig artikkel
-
Lund, Henning;
Eftedal, Ingrid;
Haug, Terje;
Krokan, Hans Einar.
(1996)
Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16.
Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
-
Slupphaug, Geir;
Mol, Clifford D.;
Kavli, Bodil;
Arvai, Andrew S.;
Krokan, Hans Einar;
Tainer, John A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Dizdaroglu, Miral;
Karakaya, Asuman;
Jaruga, Pawel;
Slupphaug, Geir;
Krokan, Hans Einar.
(1996)
Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Lehmann, A.R.;
Bridges, B.A.;
Hanawalt, P.C.;
Johnson, R.T.;
Kanaar, R.;
Krokan, Hans E..
(1996)
Workshop on processing of DNA damage.
Mutation research
Vitenskapelig artikkel
-
Lund, H.;
Eftedal, I.;
Haug, T.;
Krokan, Hans Einar.
(1996)
Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1.
Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
-
Nagelhus, T.;
Slupphaug, Geir;
Krokan, Hans Einar;
Lindmo, T..
(1996)
Fading correction for fluorescence quantitation in confocal microscopy.
Cytometry
Vitenskapelig artikkel
-
Haug, T.;
Skorpen, Frank;
Lund, H.;
Eftedal, I.;
Kvaløy, K.;
Krokan, Hans Einar.
(1996)
Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1.
Genomics, Society and Policy
Vitenskapelig artikkel
1995
-
Slupphaug, Geir;
Eftedal, Ingrid;
Kavli, Bodil;
Bharati, Sangeeta;
Helle, Nils M;
Haug, Terje.
(1995)
Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.
Biochemistry
Vitenskapelig artikkel
-
Nilsen, Hilde;
Yazdankhah, Siamak Pour;
Eftedal, Ingrid;
Krokan, Hans Einar.
(1995)
Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots.
FEBS Letters
Vitenskapelig artikkel
1993
-
Slupphaug, Geir;
Alseth, Ingrun;
Eftedal, Ingrid;
Volden, Gunnar;
Krokan, Hans Einar.
(1993)
Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification.
Analytical Biochemistry
Vitenskapelig artikkel
-
Slupphaug, G.;
Markussen, F.-H.;
Olsen, Lisbeth Charlotte;
Aasland, Rein;
Aarsæther, Niels;
Bakke, O..
(1993)
Human Uracil-DNA glycosylase is shared by the nucleus and the mitochondria.
Nucleic Acid Res
Vitenskapelig artikkel
-
Eftedal, Ingrid;
Guddal, Per Henrik;
Slupphaug, Geir;
Volden, Gunnar;
Krokan, Hans Einar.
(1993)
Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(1993)
Omega-3 fatty acids : metabolism and biological effects.
Advances in Life Sciences
Fagbok
-
Krokan, Hans Einar;
Valla, Svein;
Bones, Atle.
(1993)
Markørgener - sikkerhet for helse og miljø.
Direktoratet for naturforvaltning
Fagbok
-
Krokan, Hans Einar;
Bjerve, Kristian S;
Mørk, E..
(1993)
The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro.
Biochimica et Biophysica Acta
Vitenskapelig artikkel
1992
-
Krokan, Hans Einar.
(1992)
Expression of O(6)-methylguanine - DNA methyltransferase and uracilDNA lycosylase in human placentae from smokers and non-smokers.
Carcinogenesis
Vitenskapelig artikkel
-
Olsen, Lisbeth Charlotte;
Aasland, Rein;
Krokan, H. E.;
Helland, Dag Emil.
(1992)
Human uracil DNA glycosylase cDNA complements E.coli ung mutants.
Nucleic Acid Res
Vitenskapelig artikkel
1991
-
Slupphaug, G.;
Olsen, Lisbeth Charlotte;
Helland, Dag Emil;
Aasland, Rein;
Krokan, H. E..
(1991)
Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil- DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
1990
-
Aasland, Rein;
Olsen, Lisbeth Charlotte;
Spurr, N. K.;
Krokan, H. E.;
Helland, Dag Emil.
(1990)
Chromosomal assignment of Human Uracil-DNA Glycosylase to Chromosome 12.
Genomics
Vitenskapelig artikkel
1978
-
Wist, Erik;
Krokan, Hans E..
(1978)
Preservation by glycerol of DNA synthetic capacity of isolated HeLa cell nuclei during long term storage at low temperature.
Experimental Cell Research
Vitenskapelig artikkel
-
Wist, Erik;
Undhjem, O;
Krokan, Hans E..
(1978)
Accumulation of small fragments of DNA in isolated HeLa cell nuclei due to transient incorporation of dUMP.
Biochimica et Biophysica Acta
Vitenskapelig artikkel
1977
-
Krokan, Hans E.;
Wist, Erik;
Prydz, Hans Peter B.
(1977)
DNA replication intermediates in whole HeLa cells and isolated nuclei.
Biochimica et Biophysica Acta
Vitenskapelig artikkel
-
Krokan, Hans E.;
Wist, Erik;
Prydz, Hans Peter B.
(1977)
Effect of cytosol on DNA synthesis in isolated nuclei.
Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
1976
-
Wist, Erik;
Krokan, Hans E.;
Prydz, Hans Peter B.
(1976)
Effect of 1-beta-D-arabionsyl-cytosine-triphosphate on DNA synthesis in HeLa cell nuclei.
Biochemistry
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Lefol, Yohan Pierre;
Korfage, Tom;
Mjelle, Robin;
Prebensen, Christian Haugland;
Lüders, Torben;
Müller, Bruno.
(2023)
TiSA: TimeSeriesAnalysis - A pipeline for the analysis of longitudinal transcriptomics data.
NAR Genomics and Bioinformatics
Vitenskapelig artikkel
-
Bonagas, Nadilly;
Gustafsson, Nina M. S.;
Henriksson, Martin;
Marttila, Petra;
Gustafsson, Robert;
Wiita, Elisée.
(2022)
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nature Cancer
Vitenskapelig artikkel
-
Olinski, Ryszard;
Slupphaug, Geir;
Foksinski, Marek;
Krokan, Hans Einar.
(2021)
Genomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignancies.
International Journal of Molecular Sciences
Vitenskapelig artikkel
-
Visnes, Torkild;
Benitez-Buelga, Carlos;
Cázares-Körner, Armando;
Sanjiv, Kumar;
Hanna, Bishoy M F;
Mortusewicz, Oliver.
(2020)
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Boeckemeier, L;
Kraehenbuehl, R;
Keszthelyi, A;
Gasasira, MU;
Vernon, EG;
Beardmore, R.
(2020)
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.
Science Advances
Vitenskapelig artikkel
-
Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Visnes, Torkild;
Armando, Cazares-Körner;
Wenjing, Hao;
Wallner, Olov;
Masuyer, Geoffrey;
Loseva, Olga.
(2018)
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Science
Vitenskapelig artikkel
-
Wang, Yufei;
McKay, James D.;
Rafnar, Thorunn;
Wang, Zhaoming;
Timofeeva, Maria N.;
Broderick, Peter.
(2017)
Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer (Nature Genetics (2014) 46 (736-741)).
Nature Genetics
Errata
-
Alsøe, Lene;
Sarno, Antonio;
Carracedo Huroz, Sergio;
Domanska, Diana Ewa;
Dingler, Felix;
Lirussi, Lisa.
(2017)
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Scientific Reports
Vitenskapelig artikkel
-
Rasmussen, Erik;
Vågbø, Cathrine Broberg;
Münch, Daniel;
Krokan, Hans Einar;
Klungland, Arne;
Amdam, Gro Vang.
(2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.
Biochemistry and Biophysics Reports
Vitenskapelig artikkel
-
Robles, Ana I.;
Olsen, Karina Standahl;
Tsui, Dana W.T.;
Georgoulias, Vassilis;
Creaney, Jenette;
Dobra, Katalin.
(2016)
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Xue, JH;
Xu, GF;
Gu, TP;
Chen, GD;
Han, BB;
Xu, ZM.
(2016)
Uracil-DNA glycosylase UNG promotes tet-mediated DNA demethylation.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Helander, Linda;
Sharma, Animesh;
Krokan, Hans Einar;
Plaetzer, Kristjan;
Krammer, Barbara;
Tortik, Nicole.
(2016)
Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins.
Molecular Biosystems
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
-
Brenner, Darren. R.;
Amos, Christopher I.;
Brhane, Yonathan;
Timofeeva, Maria N.;
Caporaso, Neil;
Wang, Yufei.
(2015)
Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia.
Carcinogenesis
Vitenskapelig artikkel
-
Mjelle, Robin;
Hegre, Siv Anita;
Aas, Per Arne;
Slupphaug, Geir;
Drabløs, Finn;
Sætrom, Pål.
(2015)
Cell cycle regulation of human DNA repair and chromatin remodeling genes.
DNA Repair
Vitenskapelig artikkel
-
Wang, Yufei;
McKay, JD;
Rafnar, T;
Wang, Z;
Timofeeva, MN;
Broderick, P.
(2014)
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
Nature Genetics
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2014)
Error-free versus mutagenic processing of genomic uracil-Relevance to cancer.
DNA Repair
Vitenskapelig artikkel
-
Hu, Yi;
Ericsson, Ida;
Doseth, Berit;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2014)
Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors.
Experimental Cell Research
Vitenskapelig artikkel
-
Wallenius, Anders;
Hauser, Jannek;
Aas, Per Arne;
Sarno, Antonio;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2014)
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Molecular Immunology
Vitenskapelig artikkel
-
Zdzalik, Daria;
Vågbø, Cathrine Broberg;
Kirpekar, F;
Davydova, Erna;
Puścian, Alicja;
Maciejewska, Agnieszka M..
(2014)
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities.
PLOS ONE
Vitenskapelig artikkel
-
Helander, Linda;
Krokan, Hans Einar;
Johnsson, Anders Carl G.;
Gederaas, Odrun Arna;
Plaetzer, Kristjan.
(2014)
Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro.
Journal of Biomedical Optics
Vitenskapelig artikkel
-
Bjørngaard, Johan Håkon;
Gunnell, David;
Gabrielsen, Maiken Elvestad;
Davey Smith, George;
Skorpen, Frank;
Krokan, Hans Einar.
(2013)
The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study.
Psychological Medicine
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Ericsson, Ida;
Galashevskaya, Anastasia;
Sarno, Antonio;
Aas, Per Arne.
(2013)
Genomic uracil - potent mutagen but normal intermediate in adaptive immunity.
The FEBS Journal
Sammendrag/abstract
-
Hu, Yi;
Ericsson, Ida;
Torseth, Kathrin;
Methot, Stephen;
Sundheim, Ottar;
Liabakk, Nina-Beate.
(2013)
A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.
Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
-
Zheng, Guanqun;
Dahl, John Arne;
Niu, Yamei;
Fedorcsak, Peter;
Huang, Chun-Min;
Li, Charles J..
(2013)
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility.
Molecular Cell
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Bjørås, Magnar.
(2013)
Base Excision Repair.
Cold Spring Harbor Perspectives in Biology
Vitenskapelig artikkel
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Vitenskapelig artikkel
-
Hegre, Siv Anita;
Sætrom, Pål;
Aas, Per Arne;
Pettersen, Henrik P Sahlin;
Otterlei, Marit;
Krokan, Hans Einar.
(2013)
Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase.
DNA Repair
Vitenskapelig artikkel
-
Diaz, Javier Pena;
Hegre, Siv Anita;
Anderssen, Endre;
Aas, Per Arne;
Mjelle, Robin;
Gilfillan, Gregor Duncan.
(2013)
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Gabrielsen, Maiken Elvestad;
Romundstad, Pål Richard;
Langhammer, Arnulf;
Krokan, Hans Einar;
Skorpen, Frank.
(2013)
Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway.
European Journal of Human Genetics
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2012)
A life in DNA repair-And beyond.
DNA Repair
Leder
-
Torseth, Kathrin;
Doseth, Berit;
Hagen, Lars;
Olaisen, Camilla;
Liabakk, Nina-Beate;
Græsmann, Heidi.
(2012)
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair
Vitenskapelig artikkel
-
Doseth, Berit;
Ekre, Cecilie;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2012)
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2012)
To Repair and Protect.
International Innovation
Populærvitenskapelig artikkel
-
Krokan, Hans Einar.
(2012)
Stable Genomes and DNA Repair.
International Innovation
Populærvitenskapelig artikkel
-
Krokan, Hans Einar.
(2012)
The Essentials of DNA Repair.
Public Service Review: European Union
Populærvitenskapelig artikkel
-
Timofeeva, MN;
Hung, RJ;
Rafnar, T;
Christiani, DC;
Field, JK;
Bickeboller, H.
(2012)
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
Human Molecular Genetics
Vitenskapelig artikkel
-
Meza, Trine Johansen;
Moen, Marivi;
Vågbø, Cathrine Broberg;
Krokan, Hans Einar;
Klungland, Arne;
Grini, Paul Eivind.
(2012)
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Akbari, Mansour;
Krokan, Hans Einar.
(2012)
Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-Implications for comparative studies.
Mutation research
Vitenskapelig artikkel
-
Kazma, R;
Babron, MC;
Gaborieau, Valerie;
Génin, E;
Brennan, P;
Hung, Rayjean J..
(2012)
Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium.
Carcinogenesis
Vitenskapelig artikkel
-
Johnson, Matthew P;
Brennecke, Shaun P.;
Iversen, Ann-Charlotte;
East, Christine;
Olsen, Guro Dalheim;
Kent, Jack W.
(2012)
Genome-wide association scans identify novel maternal susceptibility loci for preeclampsia.
Pregnancy Hypertension
Sammendrag/abstract
-
Robertson, Adam Brian;
Dahl, John Arne;
Vågbø, Cathrine Broberg;
Tripathi, P;
Krokan, Hans Einar;
Klungland, Arne.
(2011)
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Arum, Carl-Jørgen;
Gederaas, Odrun Arna;
Larsen, Eivind La Puebla;
Randeberg, Lise Lyngsnes;
Hjelde, Astrid;
Krokan, Hans Einar.
(2011)
Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action.
Journal of Biomedical Optics
Vitenskapelig artikkel
-
Leihne, VIbeke;
Kirpekar, F;
Vågbø, Cathrine Broberg;
Van den Born, Erwin;
Krokan, Hans Einar;
Grini, Paul Eivind.
(2011)
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Sundheim, Ottar;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Slupphaug, Geir.
(2011)
XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage.
Environmental and Molecular Mutagenesis
Vitenskapelig artikkel
-
Sletta, Håvard;
Klinkenberg, Geir;
Winnberg, Asgeir;
Kvitvang, Hans Fredrik Nyvold;
Nilsen, Marianne Bakke;
Krokan, Hans Einar.
(2011)
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants.
Journal of Microbiological Methods
Vitenskapelig artikkel
-
Doseth, Berit;
Visnes, Torkild;
Wallenius, Anders;
Ericsson, Ida;
Sarno, Antonio;
Pettersen, Henrik Sahlin.
(2011)
Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Van den Born, Erwin;
Vågbø, Cathrine Broberg;
Songe-Møller, Lene;
Leihne, VIbeke;
Lien, Guro Flor;
Leszczynska, G.
(2011)
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nature Communications
Vitenskapelig artikkel
-
Baglo, Yan;
Sousa, Mirta;
Slupphaug, Geir;
Hagen, Lars;
Håvåg, Sissel;
Helander, Linda.
(2011)
Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways.
Photochemical and Photobiological Sciences
Vitenskapelig artikkel
-
Monsen, Vivi A Talstad;
Sundheim, Ottar;
Aas, Per Arne;
Westbye, Marianne Pedersen;
Sousa, Mirta;
Slupphaug, Geir.
(2010)
Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2010)
Advarer mot biodiesel i fossilt diesel: Svært mange kan bli syke.
Teknisk Ukeblad
Intervju tidsskrift
-
Songe-Møller, Lene;
Van den Born, Erwin;
Leihne, V;
Vågbø, Cathrine Broberg;
Kristoffersen, T;
Krokan, Hans Einar.
(2010)
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding.
Molecular and Cellular Biology
Vitenskapelig artikkel
-
Slagsvold, Jens Erik;
Pettersen, Caroline Hild;
Størvold, Gro Leite;
Follestad, Turid;
Krokan, Hans Einar;
Schønberg, Svanhild Margrethe Arentz.
(2010)
DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells.
Nutrition and Cancer
Vitenskapelig artikkel
-
Akbari, Mansour;
Solvang-Garten, Karin;
Hanssen-Bauer, Audun;
Lieske, Nora V.;
Pettersen, Henrik P Sahlin;
Pettersen, Grete Klippenvåg.
(2010)
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Otterlei, Marit;
Akbari, M.;
Slupphaug, Geir;
Aas, Per Arne.
(2010)
DNA repair and cancer.
European Journal of Cancer
Sammendrag/abstract
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel/review
-
Slagsvold, Jens Erik;
Pettersen, Caroline Hild;
Follestad, Turid;
Krokan, Hans Einar;
Schønberg, Svanhild Margrethe Arentz.
(2009)
The Antiproliferative Effect of EPA in HL60 Cells is Mediated by Alterations in Calcium Homeostasis.
Lipids
Vitenskapelig artikkel
-
Størvold, Gro Leite;
Fleten, Karianne Giller;
Olsen, Cathrine Goberg;
Follestad, Turid;
Krokan, Hans Einar;
Schønberg, Svanhild Margrethe Arentz.
(2009)
Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells.
Lipids
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
-
Akbari, Mansour;
Diaz, Javier Pena;
Andersen, Sonja Benedikte;
Liabakk, Nina-Beate;
Otterlei, Marit;
Krokan, Hans Einar.
(2009)
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.
DNA Repair
Vitenskapelig artikkel
-
Aas, Per Arne;
Diaz, Javier Pena;
Liabakk, Nina-Beate;
Krokan, Hans Einar;
Skorpen, Frank.
(2009)
Overexpression of transcription factor AP-2 stimulates the P-A promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression.
DNA Repair
Vitenskapelig artikkel
-
Landi, MT;
Chatterjee, N;
Yu, K;
Goldin, LR;
Goldstein, AM;
Rotunno, M.
(2009)
A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma.
American Journal of Human Genetics
Vitenskapelig artikkel
-
Hung, RJ;
Mckay, J;
Gaborieau, V;
Boffetta, P;
Chu, C;
Field, JK.
(2008)
Detecting new genes for tobacco-related cancers - genomewide association study of lung cancer.
European Journal of Cancer
Sammendrag/abstract
-
Akbari, Mansour;
Krokan, Hans Einar.
(2008)
Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging.
Mechanisms of Ageing and Development
Vitenskapelig oversiktsartikkel/review
-
Andersen, Sonja Benedikte;
Krokan, Hans Einar;
Baar, Cecilie Christensen;
Rakvag, Trude Teoline;
Laugsand, Eivor Alette;
Kvam, Tor-Morten.
(2008)
Identification of an alternative, putative promoter and new alternatively spliced transcripts from the human µ opioid receptor gene, OPRM1.
Palliative Medicine
Sammendrag/abstract
-
Heath, SC;
Gut, IG;
Brennan, P;
Mckay, JD;
Bencko, V;
Fabianova, E.
(2008)
Investigation of the fine structure of European populations with applications to disease association studies.
European Journal of Human Genetics
Vitenskapelig artikkel
-
McKay, JD;
Mckay, JD;
Hung, RJ;
Gaborieau, V;
Boffetta, Paolo;
Chabrier, Amelie.
(2008)
Lung cancer susceptibility locus at 5p15.33.
Nature Genetics
Vitenskapelig artikkel
-
Slagsvold, Jens Erik;
Pettersen, Caroline Hild;
Follestad, Turid;
Krokan, Hans Einar;
Schønberg, Svanhild Margrethe Arentz.
(2008)
The antiproliferative effect of EPA in HL60 cells is mediated by alterations in calcium homeostasis.
Lipids
Vitenskapelig artikkel
-
Hung, RJ;
Mckay, JD;
Gaborieau, V;
Boffetta, P;
Hashibe, M;
Zaridze, D.
(2008)
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
Nature
Vitenskapelig artikkel
-
Bathen, Tone Frost;
Holmgren, Kristin;
Lundemo, Anne Gøril;
Hjelstuen, Mari H;
Krokan, Hans Einar;
Gribbestad, Ingrid S.
(2008)
Omega-3 Fatty Acids Supress Growth of SW620 Human Colon Cancer Xenografts in Nude Mice.
Anticancer Research
Vitenskapelig artikkel
-
Akbari, Mansour;
Visnes, Torkild;
Krokan, Hans Einar;
Otterlei, Marit.
(2008)
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
DNA Repair
Vitenskapelig artikkel
-
Sundheim, Ottar;
Talstad, Vivi A;
Vågbø, Cathrine Broberg;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
AlkB demethylases flip out in different ways.
DNA Repair
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Visnes, Torkild;
Akbari, Mansour;
Hagen, Lars;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
The rate of base excision repair of uracil is controlled by the initiating glycosylase.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2008)
NBS 40 år.
NBS-nytt
Populærvitenskapelig artikkel
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
-
Jakobsen, CH;
Pettersen, Caroline Hild;
Størvold, Gro Leite;
Bremseth, Hilde;
Follestad, Turid;
Sand, Kristin.
(2008)
DHA induces ER stress and growth arrest in human colon cancer cells: association with cholesterol and calcium homeostasis.
Journal of Lipid Research
Vitenskapelig artikkel
-
Larsen, Eivind La Puebla;
Randeberg, Lise Lyngsnes;
Gederaas, Odrun Arna;
Arum, Carl-Jørgen;
Hjelde, Astrid;
Zhao, Chun-Mei.
(2008)
Monitoring of Hexyl 5-aminolevulinate Induced Photodynamic Therapy in Rat Bladder Cancer by Optical Spectroscopy.
Journal of Biomedical Optics
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2007)
Repair of small base lesions in DNA - From molecular biology to phenotype - Preface.
DNA Repair
Leder
-
Sousa, Mirta;
Krokan, Hans Einar;
Slupphaug, Geir.
(2007)
DNA-uracil and human pathology.
Molecular Aspects of Medicine
Vitenskapelig oversiktsartikkel/review
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2007)
Repair of small base lesions in DNA- from molecular biology to phenotype.
DNA Repair
Sammendrag/abstract
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Akbari, Mansour;
Visnes, Torkild;
Pettersen, Henrik P Sahlin;
Sundheim, Ottar.
(2007)
Repair og uracil in DNA by UNG2 and SMUG1 - an update.
DNA Repair
Sammendrag/abstract
-
Pettersen, Henrik P Sahlin;
Sundheim, Ottar;
Gilljam, Karin Margaretha;
Slupphaug, Geir;
Krokan, Hans Einar;
Kavli, Bodil Merete.
(2007)
Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2007)
Uracil in DNA - General mutagen, but normal intermediate in acquired immunity.
DNA Repair
Vitenskapelig artikkel
-
Akbari, Mansour;
Otterlei, Marit;
Pena-Diaz, J;
Krokan, Hans Einar.
(2007)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Vitenskapelig artikkel
-
Larsen, Eivind La Puebla;
Randeberg, Lise Lyngsnes;
Gederaas, Odrun Arna;
Arum, Carl-Jørgen;
Krokan, Hans Einar;
Chen, Duan.
(2006)
Monitoring of hALA induced PDT in rat bladder cancer by optical spectroscopy.
Lasers in Surgery and Medicine
Sammendrag/abstract
-
Hagen, Lars;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Slupphaug, Geir;
Krokan, Hans Einar.
(2006)
Genomic uracil and human disease.
Experimental Cell Research
Vitenskapelig oversiktsartikkel/review
-
Krokan, Hans Einar;
Akbari, Mansour;
Diaz, Javier Pena;
Kavli, Bodil Merete;
Otterlei, Marit;
Ericsson, Madelene.
(2006)
Base excision repair proteins in cancer prevention and acquired immune responses.
The FEBS Journal
Sammendrag/abstract
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Vitenskapelig artikkel
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Krokan, Hans Einar.
(2006)
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2006)
Preface.
DNA Repair
Vitenskapelig artikkel
-
Schønberg, Svanhild Margrethe Arentz;
Lundemo, Anne Gøril;
Fladvad, Torill;
Holmgren, Kristin;
Bremseth, Hilde;
Nilsen, Asbjørn Magne.
(2006)
Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1.
The FEBS Journal
Vitenskapelig artikkel
-
Hjelde, Astrid;
Gederaas, Odrun Arna;
Krokan, Hans Einar;
Brubakk, Alf O.
(2005)
Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines.
Medical Science Monitor
Vitenskapelig artikkel
-
Kavli, Bodil Merete;
Andersen, Sonja Benedikte;
Otterlei, Marit;
Liabakk, Nina-Beate;
Imai, K;
Fischer, A.
(2005)
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
-
Gederaas, Odrun Arna;
Schønberg, Svanhild Margrethe Arentz;
Ramstad, Ståle;
Berg, Kristian;
Johnsson, Anders Carl G.;
Krokan, Hans Einar.
(2005)
Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization.
Photochemical and Photobiological Sciences
Vitenskapelig artikkel
-
Andersen, Sonja Benedikte;
Heine, T;
Sneve, Ragnhild;
Kønig, Imbritt;
Krokan, Hans Einar;
Epe, B.
(2005)
Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.
Carcinogenesis
Vitenskapelig artikkel
-
Andersen, Sonja Benedikte;
Ericsson, Maria Elisabeth Madelene;
Dai, HY;
Diaz, Javier Pena;
Slupphaug, Geir;
Nilsen, H.
(2005)
Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice.
DNA Repair
Vitenskapelig artikkel
-
Auerbach, Paul;
Bennett, Richard A.O.;
Bailey, Elisabeth A.;
Krokan, Hans Einar;
Demple, Bruce.
(2005)
Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
-
Schønberg, Svanhild Margrethe Arentz;
Jakobsen, Caroline Hild;
Bremseth, Hilde;
Olsen, Karina Standahl;
Lundemo, Anne Gøril;
Follestad, Turid.
(2005)
Endoplasmic reticulum stress induced by DHA leads to growth arrest of human colon cancer cells.
Chemistry and Physics of Lipids
Vitenskapelig artikkel
-
Akbari, Mansour;
Hansen, Marianne Dore;
Halgunset, Jostein;
Skorpen, Frank;
Krokan, Hans Einar.
(2005)
Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner.
Journal of Molecular Diagnostics
Vitenskapelig artikkel
-
Rakvag, Trude Teoline;
Klepstad, Pål;
Baar, Cecilie Christensen;
Kvam, Tor-Morten;
Dale, Ola;
Kaasa, Stein.
(2005)
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients.
Pain
Vitenskapelig artikkel
-
Andersen, S;
Heine, T;
Sneve, Ragnhild;
Konig, I;
Krokan, HE;
Epe, B.
(2005)
Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.
Carcinogenesis
Vitenskapelig artikkel
-
Andersen, S;
Ericsson, M;
DAI, H;
Peña-Diaz, J;
Slupphaug, G;
Nilsen, Hilde.
(2005)
Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice.
DNA Repair
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2004)
Molecular and functional interactions in macromolecular repair.
European Journal of Biochemistry (EJB)
Sammendrag/abstract
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2004)
Novel aspects of macromolecular repair and relationship to human disease.
Journal of Molecular Medicine
Vitenskapelig oversiktsartikkel/review
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
-
Kvam, TM;
Baar, Cecilie Christensen;
Raakvag, Trude Teoline;
Kaasa, Stein;
Krokan, Hans Einar;
Skorpen, Frank.
(2004)
Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing.
Journal of Molecular Medicine
Vitenskapelig artikkel
-
Klepstad, Pål;
Rakvag, TT;
Kaasa, Stein;
Holthe, Monica;
Dale, Ola;
Borchgrevink, Petter Chr..
(2004)
The 118 A>G polymorphism in the human mu-opioid receptor gene may increase morphins requirements in patients with pain caused by malignant disease.
Acta Anaesthesiologica Scandinavica
Vitenskapelig artikkel
-
Akbari, Mansour;
Skjelbred, C;
Folling, I;
Sagen, J;
Krokan, Hans Einar.
(2004)
A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss.
Scandinavian Journal of Clinical and Laboratory Investigation
Vitenskapelig artikkel
-
Diaz, Javier Pena;
Akbari, Mansour;
Sundheim, Ottar;
Farez-Vidal, ME;
Andersen, S;
Sneve, R.
(2004)
Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.
Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
-
Akbari, Mansour;
Otterlei, Marit;
Diaz, Javier Pena;
Aas, Per Arne;
Kavli, Bodil;
Liabakk, Nina-Beate.
(2004)
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Akbari, M;
Skjelbred, C;
Folling, I;
Sagen, Jørn V.;
Krokan, HE.
(2004)
A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA (Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss.
Scandinavian Journal of Clinical and Laboratory Investigation
Vitenskapelig artikkel
-
Klepstad, Pål;
Rakvag, Trude Teoline;
Kaasa, Stein;
Holthe, Monica;
Dale, Ola;
Borchgrevink, Petter Chr..
(2004)
The 118 A>G polymorphism in the human µ-opioidreceptor gene may increase morphine requrements in patients with pain caused by malignant disease.
Acta Anaesthesiologica Scandinavica
Vitenskapelig artikkel
-
Akbari, M;
Skjelbred, C;
Følling, Ivar;
Sagen, J;
Krokan, H E.
(2004)
A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA Leu (UUR)) applied to a Norwegian family with diabetes mellitus and hearing loss.
Scandinavian Journal of Clinical and Laboratory Investigation
Vitenskapelig artikkel
-
Holthe, M.;
Rakvåg, Trude Teoline;
Klepstad, Pål;
Idle, Jefrrey R.;
Kaasa, Stein;
Krokan, Hans Einar.
(2003)
Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients.
The Pharmacogenomics Journal
Vitenskapelig artikkel
-
Slupphaug, Geir;
Kavli, Bodil;
Krokan, Hans Einar.
(2003)
Interacting pathways that prevent and repair oxidative DNA damage.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Nilsen, Hilde;
Stamp, G;
Andersen, Sonja;
Hrivnak, G;
Krokan, Hans Einar;
Lindahl, T.
(2003)
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.
Oncogene
Vitenskapelig artikkel
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
-
Imai, K;
Slupphaug, Geir;
Lee, W-I;
Revy, P;
Nonoyama, S;
Catalan, N.
(2003)
Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch.
Nature Immunology
Vitenskapelig artikkel
-
Holthe, Monica;
Råkvåg, Trude Teoline;
Klepstad, Pål;
Idle, Jefrrey R.;
Kaasa, Stein;
Krokan, Hans Einar.
(2003)
Identification of 10 novel single nucleotide polymorphisms and analysis of their relevance to morphine glucuronidation.
The Pharmacogenomics Journal
Vitenskapelig artikkel
-
Holthe, Monica;
Klepstad, Pål;
Zahlsen, Kolbjørn;
Borchgrevink, Petter Chr.;
Hagen, Lars;
Dale, Ola.
(2002)
Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1a1*28 polymorphisms in cancer patients on chronic morphine therapy.
European Journal of Clinical Pharmacology
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Drabløs, Finn;
Slupphaug, Geir.
(2002)
Uracil in DNA, occurrence, consequences and repair.
Oncogene
Vitenskapelig artikkel
-
Kavli, Bodil;
Sundheim, Ottar;
Akbari, Mansour;
Otterlei, Marit;
Nilsen, Hilde;
Skorpen, Frank.
(2002)
hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2002)
Fromprotein folding to new enzymes.
Tidsskrift for Den norske legeforening
Vitenskapelig artikkel
-
Holthe, Monica;
Råkvåg, Trude Teoline;
Klepstad, Pål;
Idle, Jefrrey R.;
Kaasa, Stein;
Krokan, Hans Einar.
(2002)
Sequence variationin the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphins (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients.
The Pharmacogenomics Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Slupphaug, Geir.
(2002)
Damage and repair of DNA in mammalian cells-emphasis on oxidative damage. Proceedings from International Symposium "Natural Ionising Radiation and Health".
Det Norske Videnskaps-Akademi : proceedings
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, Hilde.
(2001)
Base excision repair in a network of defence and tolerance.
Carcinogenesis
Vitenskapelig artikkel
-
Rudra, Parveen;
Krokan, Hans Einar.
(2001)
Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid.
Anticancer Research
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Prydz, H..
(2001)
Genoverføring - administrasjonsmåter, fordeler, mulige ulemper og farer.
Tidsskrift for Den norske legeforening
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Otterlei, Marit;
Nilsen, Hilde;
Kavli, Bodil;
Skorpen, Frank;
Andersen, Sonja.
(2001)
Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene.
Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
-
Dusseau, C.;
Murray, GI;
Keenan, RA;
OKelly, T.;
Krokan, Hans Einar;
McLeod, HL.
(2001)
Analysis of uracil DNA glycosylase in human colorectal cancer.
International Journal of Oncology
Vitenskapelig artikkel
-
Kvaløy, Kirsti;
Nilsen, H.;
Steinsbekk, Kristin;
Nedal, Aina;
Monterotti, Bruno;
Akbari, Mansour.
(2001)
Sequence variation in the human uracil-DNA glycosylase (UNG) gene.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Prydz, H..
(2001)
Genoverføring - administrasjonsmåter, fordeler, mulige ulemper og farer.
Tidsskrift for Den norske legeforening
Vitenskapelig artikkel
-
Prydz, Hans Peter B;
Krokan, Hans E..
(2001)
Genoverføring - Administrasjonsmåter, fordeler, mulige ulemper og farer.
TDNLF
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(2001)
Kong Olav V's kreftforskningspris til Erling Seeberg.
NBS-nytt
Populærvitenskapelig artikkel
-
Krokan, Hans Einar.
(2001)
Biologiens århundre er nå.
Fondsfinans Farmasi - Bioteknologi, Årsrapport 2000
Populærvitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Parikh, Sudip S.;
Walcher, Gunter;
Jones, Garry D.;
Slupphaug, Geir;
Krokan, Hans Einar;
Blackburn, G.Michael.
(2000)
Uracil-DNA glycosylase-DNA substrate and product structures:Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, Hilde;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair of DNA in mammalian cells.
FEBS Letters
Vitenskapelig artikkel
-
Nilsen, Hilde;
Rosewell, Ian;
Robins, Peter;
Skjelbred, Camilla;
Andersen, Sonja;
Slupphaug, Geir.
(2000)
URACIL-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication.
Molecular Cell
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Nilsen, H.;
Skorpen, Frank;
Otterlei, Marit;
Slupphaug, Geir.
(2000)
Base excision repair in mammalian cells.
FEBS Letters
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, B;
Standal, R;
Skjelbred, Camilla;
Bharati, S;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Nilsen, Hilde;
Steinsbekk, Kristin;
Otterlei, Marit;
Slupphaug, Geir;
Aas, Per Arne;
Krokan, Hans Einar.
(2000)
Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Parikh, S;
Walcher, G;
Jones, G.D;
Slupphaug, Geir;
Krokan, Hans Einar;
Blackburn, G.M.
(2000)
Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
-
Nilsen, Hilde;
Rosewell, I.;
Robins, P.;
Skjelbred, Camilla;
Andersen, Sonja;
Slupphaug, Geir.
(2000)
) Ung-deficient mice reveal a primary role of the uracil-DNA glycosylase enzyme during DNA replication.
Molecular Cell
Vitenskapelig artikkel
-
Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar.
(2000)
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
EMBO Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Schønberg, Svanhild.
(1999)
Norsk studie visar att fettsyror från fisk kan døda cancerceller.
Landstidningen, Sverige
Kronikk
-
Krokan, Hans Einar;
Schønberg, Svanhild.
(1999)
Omega 3 fettsyrer.
Østersundsposten
Kronikk
-
Schønberg, Svanhild;
Krokan, Hans Einar.
(1999)
Fisk tar knekken på kreftceller.
Adresseavisen
Kronikk
-
Waldum, Helge;
Sandvik, AK;
Angelsen, Anders;
Krokan, Hans Einar;
Falkmer, Sture Emil.
(1999)
The origin of gut and pancreatic neuroendocrine (APUD) cells - the last word?.
Journal of Pathology
Kronikk
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bhariti, Sangeeta;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1999)
Human uracil-DNA glycosylase.
NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
-
Waldum, Helge;
Sandvik, AK;
Angelsen, Anders;
Krokan, Hans Einar;
Falkmer, S.
(1999)
Re. Editorial entitled "The origin of gut and pancreatic neuroendocrine (APUD) cells-the last word?".
Journal of Pathology
Vitenskapelig artikkel
-
Rudra, Parveen K.;
Krokan, Hans Einar.
(1999)
Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells.
Anticancer Research
Vitenskapelig artikkel
-
Otterlei, Marit;
Warbrick, Emma;
Nagelhus, Toril;
Haug, Terje;
Slupphaug, Geir;
Akbari, Mansour.
(1999)
Post-replicative base excision repair in replication foci.
EMBO Journal
Vitenskapelig artikkel
-
Waldum, Helge;
Sandvik, AK;
Angelsen, Anders;
Krokan, Hans Einar.
(1999)
The origin of gut and pancreatic neuroendocrine cells - the last word?.
Journal of Pathology
Vitenskapelig artikkel
-
Waldum, Helge;
Sandvik, Arne Kristian;
Angelsen, Anders;
Krokan, Hans Einar;
Falkmer, Sture Emil.
(1999)
Letter to the Editor: Re. Editorial entitled "The origin of gut and pancreatic neuroendocrine (APUD) cells - the last word?".
Journal of Pathology
Vitenskapelig artikkel
-
Schønberg, Svanhild;
Krokan, Hans Einar.
(1999)
Fisk tar knekken på kreftceller.
Aftenposten (morgenutg. : trykt utg.)
Populærvitenskapelig artikkel
-
Krokan, Hans Einar;
Schønberg, Svanhild;
Rudra, Parveen Kumar.
(1999)
Dreper kreft : sporet etter de krefthemmende mekanismene i Omega-3 (n-3fettsyrer) er blitt sterkere.
Teknisk Ukeblad
Populærvitenskapelig artikkel
-
Skorpen, Frank;
Alm, B.;
Skjelbred, Camilla;
Aas, P.A.;
Krokan, Hans Einar.
(1998)
Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells.
Chemico-Biological Interactions
Vitenskapelig artikkel
-
Haug, T.;
Skorpen, Frank;
Aas, P.A.;
Malm, V;
Skjelbred, Camilla;
Krokan, Hans Einar.
(1998)
Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Bharati, S.;
Krokan, Hans Einar;
Kristiansen, L;
Otterlei, Marit;
Slupphaug, Geir.
(1998)
Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Parikh, S.S.;
Slupphaug, Geir;
Bharati, S;
Trainer, J.A..
(1998)
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
EMBO Journal
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Slupphaug, Geir.
(1998)
DNA-reparasjonsenzymer og deres gener.
Tidsskrift for Den norske legeforening
Vitenskapelig artikkel
-
Otterlei, Marit;
Haug, T.;
Nagelhus, T.A;
Slupphaug, Geir;
Lindmo, T.;
Krokan, Hans Einar.
(1998)
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Parikh, S. Sudip;
Mol, Clifford D.;
Slupphaug, Geir;
Bharati, Sangeta;
Krokan, Hans Einar;
Yainer, John A..
(1998)
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Skorpen, Frank;
Skjelbred, Camilla;
Aas, P.A.;
Alm, B.;
Schønberg, S.A.;
Krokan, Hans Einar.
(1998)
Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus.
Mutation Research (DNA Repair)
Vitenskapelig artikkel
-
Nøding, R.;
Schønberg, S.A.;
Krokan, Hans Einar;
Bjerve, K.S..
(1998)
Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media.
Lipids
Vitenskapelig artikkel
-
Nilsen, H.;
Otterlei, Marit;
Haug, T.;
Solum, K.;
Nagelhus, T.A;
Skorpen, Frank.
(1997)
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Nagelhus, T.;
Haug, T.;
Singh, K.K.;
Keshav, K.F.;
Skorpen, Frank;
Bharati, S..
(1997)
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Schønberg, S.M.;
Rudra, P.K.;
Nøding, R.;
Bjerve, K.S;
Krokan, Hans Einar.
(1997)
Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids.
Carcinogenesis
Vitenskapelig artikkel
-
Schønberg, Svanhild A.;
Rudra, Parveen K.;
Nøding, Randi;
Skorpen, Frank;
Bjerve, Kristian S;
Krokan, Hans Einar.
(1997)
Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids.
Carcinogenesis
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Standal, Rune;
Slupphaug, Geir.
(1997)
DNA glycosylase in the base excision repair of DNA.
Biochemical Journal
Vitenskapelig artikkel
-
Dizdaroglu, M.;
Karakaya, A.;
Jaruga, P.;
Slupphaug, Geir;
Krokan, Hans Einar.
(1996)
Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Slupphaug, Geir;
Kavli, B.;
Mol, C.D.;
Arvai, A.;
Krokan, Hans Einar;
Tainer, J.A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Kavli, B.;
Slupphaug, Geir;
Mol, C.D.;
Arvai, A.S.;
Petersen, S.B.;
Tainer, J.A..
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Kavli, Bodil;
Slupphaug, Geir;
Mol, Clifford D.;
Arvai, Andrew S.;
Petersen, Steffen B.;
Tainer, John A..
(1996)
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
EMBO Journal
Vitenskapelig artikkel
-
Haug, Terje;
Skorpen, Frank;
Kvaløy, Kirsti;
Eftedal, Ingrid;
Lund, Henning;
Krokan, Hans Einar.
(1996)
Human uracil-DNA glycosylase gene : sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1.
Genomics
Vitenskapelig artikkel
-
Lund, Henning;
Eftedal, Ingrid;
Haug, Terje;
Krokan, Hans Einar.
(1996)
Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16.
Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
-
Slupphaug, Geir;
Mol, Clifford D.;
Kavli, Bodil;
Arvai, Andrew S.;
Krokan, Hans Einar;
Tainer, John A..
(1996)
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature
Vitenskapelig artikkel
-
Dizdaroglu, Miral;
Karakaya, Asuman;
Jaruga, Pawel;
Slupphaug, Geir;
Krokan, Hans Einar.
(1996)
Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Lehmann, A.R.;
Bridges, B.A.;
Hanawalt, P.C.;
Johnson, R.T.;
Kanaar, R.;
Krokan, Hans E..
(1996)
Workshop on processing of DNA damage.
Mutation research
Vitenskapelig artikkel
-
Lund, H.;
Eftedal, I.;
Haug, T.;
Krokan, Hans Einar.
(1996)
Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1.
Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
-
Nagelhus, T.;
Slupphaug, Geir;
Krokan, Hans Einar;
Lindmo, T..
(1996)
Fading correction for fluorescence quantitation in confocal microscopy.
Cytometry
Vitenskapelig artikkel
-
Haug, T.;
Skorpen, Frank;
Lund, H.;
Eftedal, I.;
Kvaløy, K.;
Krokan, Hans Einar.
(1996)
Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1.
Genomics, Society and Policy
Vitenskapelig artikkel
-
Slupphaug, Geir;
Eftedal, Ingrid;
Kavli, Bodil;
Bharati, Sangeeta;
Helle, Nils M;
Haug, Terje.
(1995)
Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.
Biochemistry
Vitenskapelig artikkel
-
Nilsen, Hilde;
Yazdankhah, Siamak Pour;
Eftedal, Ingrid;
Krokan, Hans Einar.
(1995)
Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots.
FEBS Letters
Vitenskapelig artikkel
-
Slupphaug, Geir;
Alseth, Ingrun;
Eftedal, Ingrid;
Volden, Gunnar;
Krokan, Hans Einar.
(1993)
Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification.
Analytical Biochemistry
Vitenskapelig artikkel
-
Slupphaug, G.;
Markussen, F.-H.;
Olsen, Lisbeth Charlotte;
Aasland, Rein;
Aarsæther, Niels;
Bakke, O..
(1993)
Human Uracil-DNA glycosylase is shared by the nucleus and the mitochondria.
Nucleic Acid Res
Vitenskapelig artikkel
-
Eftedal, Ingrid;
Guddal, Per Henrik;
Slupphaug, Geir;
Volden, Gunnar;
Krokan, Hans Einar.
(1993)
Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Krokan, Hans Einar;
Bjerve, Kristian S;
Mørk, E..
(1993)
The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro.
Biochimica et Biophysica Acta
Vitenskapelig artikkel
-
Krokan, Hans Einar.
(1992)
Expression of O(6)-methylguanine - DNA methyltransferase and uracilDNA lycosylase in human placentae from smokers and non-smokers.
Carcinogenesis
Vitenskapelig artikkel
-
Olsen, Lisbeth Charlotte;
Aasland, Rein;
Krokan, H. E.;
Helland, Dag Emil.
(1992)
Human uracil DNA glycosylase cDNA complements E.coli ung mutants.
Nucleic Acid Res
Vitenskapelig artikkel
-
Slupphaug, G.;
Olsen, Lisbeth Charlotte;
Helland, Dag Emil;
Aasland, Rein;
Krokan, H. E..
(1991)
Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil- DNA glycosylase.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Aasland, Rein;
Olsen, Lisbeth Charlotte;
Spurr, N. K.;
Krokan, H. E.;
Helland, Dag Emil.
(1990)
Chromosomal assignment of Human Uracil-DNA Glycosylase to Chromosome 12.
Genomics
Vitenskapelig artikkel
-
Wist, Erik;
Krokan, Hans E..
(1978)
Preservation by glycerol of DNA synthetic capacity of isolated HeLa cell nuclei during long term storage at low temperature.
Experimental Cell Research
Vitenskapelig artikkel
-
Wist, Erik;
Undhjem, O;
Krokan, Hans E..
(1978)
Accumulation of small fragments of DNA in isolated HeLa cell nuclei due to transient incorporation of dUMP.
Biochimica et Biophysica Acta
Vitenskapelig artikkel
-
Krokan, Hans E.;
Wist, Erik;
Prydz, Hans Peter B.
(1977)
DNA replication intermediates in whole HeLa cells and isolated nuclei.
Biochimica et Biophysica Acta
Vitenskapelig artikkel
-
Krokan, Hans E.;
Wist, Erik;
Prydz, Hans Peter B.
(1977)
Effect of cytosol on DNA synthesis in isolated nuclei.
Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
-
Wist, Erik;
Krokan, Hans E.;
Prydz, Hans Peter B.
(1976)
Effect of 1-beta-D-arabionsyl-cytosine-triphosphate on DNA synthesis in HeLa cell nuclei.
Biochemistry
Vitenskapelig artikkel
Bøker
-
Slupphaug, Geir;
Krokan, Hans Einar.
(2018)
Genomic Uracil - Evolution, Biology, Immunology and Disease.
World Scientific
World Scientific
Fagbok
-
Smeland, Erlend;
Prydz, Hans;
Ørstadvik, Karen Helene;
Frøland, Stig;
Aamdal, Steinar;
Myklebost, Ola.
(2000)
Genterapi Status og fremtidige muligheter innen klinisk medisin.
Lobo Grafisk AS
Fagbok
-
Krokan, Hans Einar;
Skorpen, Frank;
Otterlei, Marit;
Bharati, S;
Steinsbekk, Kristin;
Nilsen, Hilde.
(1998)
Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis.
DNA damage and repair: Oxygen Radical Effects, Cellular Prote ction and Biological Consequences.
Fagbok
-
Krokan, Hans Einar.
(1993)
Omega-3 fatty acids : metabolism and biological effects.
Advances in Life Sciences
Fagbok
-
Krokan, Hans Einar;
Valla, Svein;
Bones, Atle.
(1993)
Markørgener - sikkerhet for helse og miljø.
Direktoratet for naturforvaltning
Fagbok
Del av bok/rapport
-
Kavli, Bodil Merete;
Slupphaug, Geir;
Krokan, Hans Einar.
(2020)
Genomic Uracil in Biology, Immunity and Cancer.
Royal Society of Chemistry (RSC) Publishing
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Slupphaug, Geir;
Krokan, Hans Einar.
(2018)
Genomic Uracil – Valuable Tool in Molecular Biology but Inherent Problem in Sequencing of Ancient DNA.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
Viral Uracil - Uracil DNA glycosylases and dUTPases.
World Scientific
Faglig kapittel
-
Slupphaug, Geir;
Kavli, Bodil Merete;
Krokan, Hans Einar.
(2018)
Routes to Uracil in DNA.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir.
(2018)
DNA Repair is Integrated with Many Cellular Processes.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Sarno, Antonio;
Slupphaug, Geir.
(2018)
Enzymology of Genomic Uracil Repair.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Kavli, Bodil Merete;
Slupphaug, Geir;
Drabløs, Finn.
(2018)
The Earth, Life and Genomic Uracil.
World Scientific
Faglig kapittel
-
Krokan, Hans Einar;
Slupphaug, Geir;
Kavli, Bodil Merete.
(2017)
Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Larsen, Eivind La Puebla;
Randeberg, Lise Lyngsnes;
Gederaas, Odrun Arna;
Krokan, Hans Einar;
Hjelme, Dag Roar;
Svaasand, Lars O..
(2007)
In vitro study on methemoglobin formation in erythrocytes following hexyl-aminolevulinate induced photodynamic therapy.
SPIE - The International Society for Optics and Photonics
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Smeland, Erlend B;
Prydz, Hans Peter B;
Ørstavik, Karen Helene;
Frøland, Stig Sophus;
Aamdal, Steinar;
Myklebost, Ola.
(2000)
Genterapi. Status og fremtidige muligheter innen klinisk medisin.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Krokan, Hans Einar.
(1999)
Kapittel 16: Vann og elektrolytter.
Cappelen Damm Høyskoleforlaget
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
-
Krokan, Hans Einar;
Standal, Rune;
Bharati, Sangeeta;
Otterlei, Marit;
Haug, Terje;
Slupphaug, Geir.
(1997)
Uracil in DNA and the family of concerved uracil DNA glycosylases.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
Rapport
-
Helander, Linda;
Krokan, Hans Einar;
Gederaas, Odrun Arna;
Johnsson, Anders Carl G.;
Chen, Duan.
(2015)
Hexylaminolevulinate Photodynamic Treatment of Cancer Cell Lines. PhD Thesis.
Tapir Akademisk Forlag
Tapir Akademisk Forlag
Doktorgradsavhandling
-
Overland, Hilde Bremseth;
Schønberg, Svanhild Margrethe Arentz;
Krokan, Hans Einar.
(2013)
ER stress, reactive oxygen species and autophagy in colon cancer cells treated with polyunsaturated marine fatty acids.
Doktoravhandlinger ved NTNU (1)
Doktorgradsavhandling
-
Monsen, Vivi A Talstad;
Krokan, Hans Einar;
Aas, Per Arne.
(2010)
Mechanisms of alkylation damage repair by human AlkB homologues.
NTNU
Doktorgradsavhandling
-
Krokan, Hans Einar;
Visnes, Torkild.
(2009)
DNA Excision repair of uracil and 5-fluorouracil in human cancer cell lines.
Det medisinske fakultet, NTNU
Doktorgradsavhandling
-
Grøsvik, K;
Slupphaug, Geir;
Krokan, Hans Einar.
(2002)
"Characterisation of uracil-exising enzyme activities in organ extracts from UNG knockout and wild-type mice.".
NTNU
Hovedfagsoppgave
-
Nygård, M;
Nilsen, M;
Remseth, V;
Slupphaug, Geir;
Krokan, Hans Einar.
(2002)
Uttrykk av det membran-modifiserende enzymet UDPDG i E.coli som funksjon av dyrkningsbetingelser og induksjon av DNA-skader.
[Mangler utgivernavn]
Hovedfagsoppgave
Formidling
2017
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PosterLundbæk, Marie Benner; Sarno, Antonio; Liabakk, Nina-Beate; Aas, Per Arne; Krokan, Hans Einar; Kavli, Bodil Merete. (2017) Mitochondrial uracil-DNA glycosylase UNG1 supports class switch recombination and genomic uracil processing in mouse B-cell. Keystone B-cells and T Follicular Helper cells: Controling Long-Lived Immunity , Whistler 2017-04-23 - 2017-04-27
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PosterAlsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix; Lirussi, Lisa. (2017) Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1 . 6th EU-US Conference on Repair of endogenous DNA damage 2017-09-24 - 2017-09-28
2016
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Vitenskapelig foredragKrokan, Hans Einar; Kavli, Bodil Merete; Pettersen, Henrik Sahlin; Sætrom, Pål; Galashevskaya, Anastasia; Sarno, Antonio. (2016) Genomic Uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan , Matsue 2016-11-13 - 2016-11-17
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Vitenskapelig foredragKavli, Bodil Merete; Pettersen, Henrik Sahlin; Ericsson, Ida; Hu, Yi; Krokan, Hans Einar. (2016) AID og genomisk uracil; kilde til mutasjoner og utvikling av B-celle lymphom. Onkologisk forum Onkologisk forum 2016 , Scandic hotel- Lerkendal, Trondheim 2016-11-17 - 2016-11-18
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Vitenskapelig foredragLundbæk, Marie Benner; Sarno, Antonio; Liabakk, Nina-Beate; Krokan, Hans Einar; Kavli, Bodil Merete. (2016) Mitochondrial UNG1 supports class switch recombination in mouse B-cells. 10th 3R Symposium Organzing Committee 10th 3R International Symposium , Matsue 2016-11-13 - 2016-11-17
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Vitenskapelig foredragKrokan, Hans Einar; Pettersen, Henrik Sahlin; Mjelle, Robin; Hegre, Siv Anita; Sætrom, Pål; Drabløs, Finn Sverre. (2016) REGULATION OF BASE EXCISION REPAIR – CANONICAL AND NON-CANONICAL PROCESSING OF GENOMIC URACIL. Russian Academy of Sciences, Siberian branch 10th International Multiconference on Bioinformatics of Genome Regulation and Structure\Systems Biology , Akademorodok, Novosibirsk 2016-08-29 - 2016-09-03
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Vitenskapelig foredragNilsen, Hilde; Kroustallaki, Pinelopi; Alsøe, Lene; Huroz, Sergio C; Sarno, Antonio; Esbensen, Ying. (2016) Telomere maintenance defects in mice deficient in SMUG1 uracil-DNA glycosylase. 10th 3R International Symposium Organizing Committee 10th 3R International Symposium , Matsue 2016-11-13 - 2016-11-17
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Vitenskapelig foredragSarno, Antonio; Alsøe, Lene; Carracedo, Sergio; Tekin, Nuriya Basdag; Gupta, Tanima Sen; Jobert, Laure. (2016) UNG and SMUG1 complement each other in DNA uracil excision and DNA 5-hydroxymethyluracil originates from 5-hydroxymethylcytosine deamination in mice. 10th 3R International Symposium Organizing Committee 10th 3R International Symposium , Matsue 2016-11-13 - 2016-11-17
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Faglig foredragKrokan, Hans Einar; Slupphaug, Geir; Sætrom, Pål; Sarno, Antonio; Galashevskaya, Anastasia; Lundbæk, Marie Benner. (2016) Genomic uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. Turkish Society of Toxicology. Eurotox 2016 , Sivilla 2016-09-04 -
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Vitenskapelig foredragKrokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2016) DNA Repair in diagnosis and therapy of cancer - opportunities and problems. NTNU 1st International NTNU Symposium on Clinical Biomarkers of Cancer , Trondheim 2016-06-16 - 2016-06-17
2015
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Vitenskapelig foredragKrokan, Hans Einar. (2015) All the things U are. Uiniversitetet i Oslo Tomas Lindahl Conference on DNA Repair , Oslo 2015-06-17 - 2015-06-21
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Faglig foredragKrokan, Hans Einar. (2015) Nobelprisen i kjemi for 2015 til forskere innen DNA reparasjon . Gløshaugen Akademiske Klubb, NTNU Gløshaugen Akademiske Klubb , Trondheim 2015-12-03 -
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IntervjuKrokan, Hans Einar. (2015) Denne har funne oppskrifta på langt liv. nrk.no nrk.no [Internett] 2015-01-06
2014
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PosterRasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne. (2014) Epigenetically modified cytosines in the honey bee genome. The Ecology of Food Perception Unconventional Model Animals in Food & Health , Oslo 2014-03-20 - 2014-03-21
2013
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IntervjuKrokan, Hans Einar. (2013) Milepælstudie avslører kreftmutasjoner. forskning.no forskning.no [Internett] 2013-08-18
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PosterFonseca, Davi de Miranda; Baar, Cecilie Christensen; Assefa, Netsanet Gizaw; Moe, Elin; Liabakk, Nina-Beate; Leiros, Hanna-Kirsti S.. (2013) Thermo-sensitive human UNG-mutants. The Structural Cell Biology of DNA Repair Machines effort XII Annual SBDR Program Project Workshop , Berkeley, CA 2013-04-11 - 2013-04-13
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PosterRasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne. (2013) Presence of modified cytosines in the honey bee genome. Insect Nutritional Homeostasis , Bonn 2013-05-01 - 2013-05-04
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IntervjuKrokan, Hans Einar. (2013) 4-tråda DNA funne i menneskeceller. NRK.no/viten NRK.no/viten [Internett] 2013-01-21
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PosterPena-Diaz, Javier; Hegre, Siv Anita; Anderssen, Endre; Aas, Per Arne; Mjelle, Robin; Gilfillan, Gregor Duncan. (2013) Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication. Norwegian Biochemical Society Norwegian Biochemical Society Contact Meeting , Lillehammer 2013-01-31 - 2013-02-03
2012
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Vitenskapelig foredragKrokan, Hans Einar. (2012) Genomic Uracil-A Potent Mutagen, But Normal Intermediate in Adaptive Immunity. University of Texas Southwestern Medical Center Pathology Seminar Series – Special Lecture , Dallas 2012-10-05 - 2012-10-06
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Vitenskapelig foredragKrokan, Hans Einar. (2012) Uracil in DNA – Generation and Processing. L.H. Bergersen, V. A. Bohr, K W. Caldecott, A. et. al. 4th Genome Dynamics in Neuroscience, Genome Instability in Aging and Brain Disease 2012-09-19 - 2012-09-22
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Populærvitenskapelig foredragKrokan, Hans Einar. (2012) Hvordan klarer organismer å vedlikeholde arvematerialet?. Sør-Trøndelag fylkeskommune Nettverkssamling i biologi/kjemi Sør-Trøndelag Fylkeskommune , Trondheim 2012-11-01 - 2012-11-01
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Vitenskapelig foredragKrokan, Hans Einar. (2012) Genomic uracil - general mutagen, but normal intermediate in adaptive immunity. European Environmental Mutagenesis Society 42nd EEMS Annual Conference , Warsaw 2012-09-16 - 2012-09-20
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Vitenskapelig foredragKrokan, Hans Einar. (2012) Genomic uracil – Friend and foe. Gene Center - University of Munich Gene Center/SFB 646 Seminar Series , München 2012-10-29 - 2012-10-29
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PosterFonseca, Davi de Miranda; Moe, Elin; Liabakk, Nina-Beate; Baar, Cecilie Christensen; Skorpen, Frank; Krokan, Hans Einar. (2012) Thermo-sensitive mutants of UNG protein studied by structural experiments – Perspectives. The 3rd Erling Seeberg Symposium on DNA Repair , Trondheim and Ørland 2012-06-19 - 2012-06-24
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Vitenskapelig foredragJohnson, Matthew P; Brennecke, Shaun P.; Iversen, Ann-Charlotte; East, C; Olsen, Guro Dalheim; Kent, J. (2012) Genome-wide association scans identify novel maternal susceptibility loci for preeclampsia. ISSHP The XVIII ISSHP World Congress , Geneva 2012-07-09 - 2012-07-12
2011
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Vitenskapelig foredragMunyeshyaka, Aloys; Helander, Linda; Plaetzer, Kristjan; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Comparison of light intensities Hexylaminolevulinate mediated photodynamic therapy. Noffof Årsmøte til Noffof , Radiumhospitalet, Oslo 2011-11-18 - 2011-11-18
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PosterMunyeshyaka, Aloys; Helander, Linda; Plaetzer, Kristjan; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Hexylaminolevulinate mediated photodynamic therapy with blue light on five cancer cell lines- a cytotoxicity study. BioStruct BioStruct , Jægtvollen 2011-10-01 - 2011-10-04
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IntervjuKrokan, Hans Einar. (2011) Intervju om HeLa cellene fra kreftpasienten Henrietta Lacks. NRK P3 NRK P3 [Radio] 2011-11-30
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Vitenskapelig foredragKrokan, Hans Einar. (2011) Functions of different uracil-DNA glycosylases and importance of tight cell cycle regulation. Leiden University Medical Center Responses to DNA damage: from molecular mechanism to human disease , Egmond aan Zee 2011-04-03 - 2011-04-08
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Populærvitenskapelig foredragKrokan, Hans Einar. (2011) Idédugnad om Menneskekroppen: ”Flaks og uflaks med gener”. Universitetet i Oslo 200-års jubiléet for Universitetet i Oslo , Oslo, Blindern 2011-10-15 - 2011-10-15
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PosterBaglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. University of Dublin Cancer Proteomics 2011, European Molecular Biology Organization , The Burlington Hotel, Dublin 2011-06-20 - 2011-06-23
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PosterPettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. UiO 4th EU-USA conference on DNA base damage and repair , Holmenkollen Park Hotell 2011-05-18 - 2011-05-22
2010
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Vitenskapelig foredragKrokan, Hans Einar. (2010) DNA Repair and Cancer. European Association for Cancer Research 21st Meeting of the European Association for Cancer Research , Oslo 2010-06-26 - 2010-06-29
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ProgramdeltagelseKrokan, Hans Einar. (2010) Intervju vedrørende mulig økt karsinogenisitet pga. økt opptak av PAH forbindelser. NRK, Schrødingers katt NRK, Schrødingers katt [TV] 2010-11-25
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Vitenskapelig foredragKrokan, Hans Einar. (2010) DNA Repair Proteins in prevention and induction of mutations. European Environmental Mutagen Society Joint Meeting of European Environmental Mutagen Society (EEMS) and the Society for Free Radical Research (SFFR). , Oslo 2010-09-12 - 2010-09-18
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ProgramdeltagelseKrokan, Hans Einar. (2010) Intervju om ”Syntetisk liv (etter publikasjon om syntetisk bakterie, Craig Venter), samt samtale om vår forskning på reparasjon av gener ved NTNU. NRK Trønder-radioen 21.05.2010 NRK Trønder-radioen 21.05.2010 [Radio] 2010-05-21
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. NTNU 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
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Populærvitenskapelig foredragKrokan, Hans Einar. (2010) Hvordan vedlikeholder vi vårt arvemateriale?. Gløshaugen Akademiske Klubb Seminarserie , Trondheim 2010-11-18 - 2010-11-18
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Vitenskapelig foredragMeza, Trine Johansen; Moen, Marivi N.; Vågbø, Cathrine B.; Ulleland, Marius; Krokan, Hans Einar; Arne, Klungland. (2010) The DNA dioxygenase AtALKBH2 protects Arabidopsis thaliana against methylation damage. 9th Norwegian Arabidopsis Meeting , Oslo 2010-11-11 - 2010-11-11
2009
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ProgramdeltagelseKrokan, Hans Einar. (2009) TV program, NRK1, Schrødingers katt - Forskningspolitikk. NRK1 TV NRK1 TV [TV] 2009-01-22
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Vitenskapelig foredragSlupphaug, Geir; Doseth, Berit; Kavli, Bodil Merete; Visnes, Torkild; Hagen, Lars; Torseth, Kathrin. (2009) Genomic uracil processing in mice and men. 2.nd Erling Seeberg symposium on DNA repair , Ålesund/Geiranger 2009-06-20 - 2009-06-25
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Vitenskapelig foredragAas, Per Arne; Diaz, Javier Pena; Liabakk, Nina-Beate; Krokan, Hans Einar; Skorpen, Frank. (2009) Overexpression of transcription factor AP-2 stimulates the P(A) promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression. IKM Tirdagsforedrag-IKM , Medisinsk Teknisk Forskningssenter 2009-05-18 - 2009-05-18
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Vitenskapelig foredragKrokan, Hans Einar. (2009) Genome wide association studies on gene variants predisposing to lung cancer. St. Olavs Hospital og NTNU Seminar i molekylærmedisin , Trondheim 2009-01-28 - 2009-01-28
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Vitenskapelig foredragKrokan, Hans Einar. (2009) Mechanism and fidelity of processing of uracil in DNA. Integrated Project in DNA Repair (EU) International symposium: DNA Damage response and repair mechanisms , Heraklion, Crete, Greece 2009-04-20 - 2009-04-23
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Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair 2009-06-20 - 2009-06-25
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Vitenskapelig foredragKrokan, Hans Einar. (2009) Genvarianter som predisponerer for lungekreft. NTNU Seminar i Molekylærmedisin, 28.01.2009, Trondheim; , Trondheim 2009-01-28 - 2009-01-28
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Vitenskapelig foredragKrokan, Hans Einar. (2009) Genetic predisposition to lung cancer – common SNPs important cause. Det Norske Vitenskaps-Akademi Sigurd K. Thoresen Foundation Workshop - HUMAN GENOMIC VARIATION AND DISEASE , Oslo 2009-10-06 - 2009-10-06
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Vitenskapelig foredragKrokan, Hans Einar. (2009) DNA-interacting proteins as molecular machines. NTNU 4th NTNU NanoLab User Meeting , Trondheim 2009-05-13 - 2009-05-13
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Vitenskapelig foredragKrokan, Hans Einar. (2009) Nobelpriser i medisin og fysiologi og i kjemi 2009. NTVA Møte i NTVA , Trondheim 2009-11-10 - 2009-11-10
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Vitenskapelig foredragKrokan, Hans Einar; Visnes, Torkild; Doseth, Berit; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete. (2009) Uracil in DNA and its processing. E. Dogliotti, H. Krokan, T. Stevnsner, S. Mitra, S.H. Wilson 3rd US-EU Conference- Repair of Endogenous Genome Damage , Moody Gardens Hotel, Galveston, Texas 2009-02-21 - 2009-02-25
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Vitenskapelig foredragHelander, Linda; Plaetzer, Kristjan; Krammer, Barbara; Krokan, Hans Einar; Gederaas, Odrun Arna. (2009) Reactive oxygen species and cytotoxicity in rat bladder cancer cells (AY-27) after hexyl 5-aminolevulinate-induced photodynamic therapy. European Society for Photobiology 13th Congress od European Society for Photobiology , Wroclaw 2009-09-05 - 2009-09-10
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Vitenskapelig foredragGederaas, Odrun Arna; Husebye, Harald; Hjelde, Astrid; Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Helander, Linda. (2009) In vivo and in vitro detection of PpIX after treatment with hexyl 5-aminolevulinate and light. European platform for Photodynamic medicine european society for Photobiology , Wroclaw 2009-09-05 - 2009-09-10
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Vitenskapelig foredragGederaas, Odrun Arna; Hjelde, Astrid; Randeberg, Lise Lyngsnes; Halaas, Øyvind; Høgset, Anders; Krokan, Hans Einar. (2009) Photochemical Internalisation (PCI). IKM, NTNU Prosjektmøte, NTNU , IKM, NTNU 2009-03-09 - 2009-03-09
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PosterPsonka-Antonczyk, Katarzyna Maria; Akbari, Mansour; Otterlei, Marit; Krokan, Hans Einar; Stokke, Bjørn Torger. (2009) Uracil-DNA glycosylase (UNG) interacting with mismatched DNA – a single molecule approach. European Biophysical Societies' Association European Biophysics Congress , Genoa 2009-07-11 - 2009-07-15
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PosterHenrik Sahlin, Pettersen; Visnes, Torkild; Vågbø, Cathrine Broberg; Kavli, Bodil Merete; Krokan, Hans Einar. (2009) Cytotoxicity of 5-fluorouracil is mainly due to RNA effects and thymidylate synthase inhibition, not excessive DNA repair. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair , Ålesund og Geiranger 2009-06-20 - 2009-06-25
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PosterTalstad, Vivi A; Sundheim, Ottar; Aas, Per Arne; Krokan, Hans Einar. (2009) Structural basis for substrate specificity of human AlkB homologues 2 and 3. International symposium: DNA Damage Response and Repair Mechanisms , Heraklion, Crete 2009-04-20 - 2009-04-23
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PosterHegre, Siv Anita; Sætrom, Pål; Aas, Per Arne; Olsen, Lene Christin; Lundbæk, Marie Benner; Diaz, Javier Pena. (2009) Multiple microRNAs appear to regulate the DNA repair enzyme UNG2 during the cell cycle. Keystone Symposia MicroRNA and Cancer Conference , Keystone, Colorado 2009-06-10 - 2009-06-15
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PosterBruheim, Per; Sletta, Håvard; Klinkenberg, Geir; Ellingsen, Trond Erling; Krokan, Hans Einar; Otterlei, Marit. (2009) Systems biology and high resolution genome-wide phenotyping of yeast used for identification of cellular and molecular effects of DNA damaging agents. 3rd US-EU Workshop "Systems level understanding of DNA damage responses" , Egmond aan Zee 2009-03-30 - 2009-04-01
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Populærvitenskapelig foredragKrokan, Hans Einar. (2009) Hva kreves for å få professor kompetanse?. SOMA - Linjeforening for alle masterstudenter på DMF ved NTN Møte , Trondheim 2009-10-28 - 2009-10-28
2008
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Vitenskapelig foredragGederaas, Odrun Arna; Hjelde, Astrid; Husebye, Harald; Helander, Linda; Sæterbø, Kristin Grendstad; Krokan, Hans Einar. (2008) Effects of hexyl 5-aminolevulinate and light in rat bladder cancer cells. Ruder Boskovic Institute, Zagreb, Croatia Photodiagnosis and Photodynamic therapy, EMMP, Dubrovnik , Dubrovnic 2008-03-24 - 2008-03-28
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Vitenskapelig foredragHelander, Linda; Gederaas, Odrun Arna; Hjelde, Astrid; Johnsson, Anders; Krokan, Hans Einar; Melø, Thor Bernt. (2008) Effects of hexyl 5-aminolevulinate and light in rat bladder cancer cells. Noffof Årsmøte i NOFFOF, Norsk Forening for Fotobiologi og Fotomedisin, Blindern, Oslo, Norge , Blindern, Oslo 2008-11-07 - 2008-11-07
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Vitenskapelig foredragBaas, Nils Andreas; Børresen-Dale, Anne-Lise; Krokan, Hans Einar; Levine, Arnold. (2008) Conference on systems biology and disease. Konferanse 2008-08-18 - 2008-08-19
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Vitenskapelig foredragKrokan, Hans Einar. (2008) Genetic variability and lung cancer. Norsk Biokjemisk Selskap, UMB Seminar Norsk Biokjemisk Selskap , Ås 2008-12-11 - 2008-12-11
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Vitenskapelig foredragKrokan, Hans Einar. (2008) Researcher initiative as creative force in shaping of university strategy - some personal experiences. Institutt for bioteknologi, NTNU Minisymposium on Microbial Biotechnology 2008-11-17 - 2008-11-17
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Vitenskapelig foredragKrokan, Hans Einar. (2008) DNA Repair, genetic variability and human cancer. Onkologisk forum Onkologisk forum 2008 2008-12-19 - 2008-12-21
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Vitenskapelig foredragKrokan, Hans Einar. (2008) DNA Repair and Human Disease. Den svenske patologiförening Patologiföreningens Vårmöte 22.-25. mai, , Uppsala 2008-05-22 - 2008-05-24
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Vitenskapelig foredragKrokan, Hans Einar. (2008) DNA Repair population studies. Consortium EU Integrated Project DNA Damage Response and Repair Mechanisms Annual Meeting , Rotterdam 2008-04-16 - 2008-04-19
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Vitenskapelig foredragKrokan, Hans Einar. (2008) Genetiske polymorfismer ved lungekreft - en multisenterstudie. HUNT Biobank Inforamsjonsmøte om biobankplattformen i FUGE , Trondheim 2008-06-05 - 2008-06-05
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Vitenskapelig foredragKrokan, Hans Einar. (2008) Genome-wide scans for SNPs predisposing to cancer. Universitetet i Tromsø Seminar during "Tromsø Cancer Course" , Tromsø 2008-04-23 - 2008-04-23
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Vitenskapelig foredragKrokan, Hans Einar. (2008) DNA Repair - from Structure to Population Studies and Human Disease. Danish Centre for Molecular Gerontology Aging - from molecules to population , Helsingør 2008-05-12 - 2008-05-14
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Vitenskapelig foredragKrokan, Hans Einar. (2008) Uracil in DNA and its processing by different DNA glycosylases. Royal Society Royal Society Discussion Meeting , London 2008-06-09 - 2008-06-10
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Vitenskapelig foredragSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance , St. Petersburg 2008-06-24 - 2008-06-26
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IntervjuSkorpen, Frank; Krokan, Hans Einar. (2008) NTNU-forskere fant lungekreftgen. Adresseavisen Adresseavisen [Avis] 2008-04-04
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PosterTalstad, Vivi A; Sundheim, Ottar; Aas, Per Arne; Krokan, Hans Einar. (2008) Identification of the motif that determines double strand substrate preference of hABH2 by domain swapping between hABH3 and hABH2. DNA Repair EU Integrated Project DNA repair annual meeting 2008 , Rotterdam 2008-04-16 - 2008-04-18
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PosterHelander, Linda; Gederaas, Odrun Arna; Hjelde, Astrid; Johnsson, Anders; Krokan, Hans Einar; Melø, Thor Bernt. (2008) Effects of hexyl 5-aminolevulinate and light in rat bladder cancer cells. 7th International Symposium on Photodynamic Therapy and Photodiagnosis in Clinical Practice, Brixen/Bressanone, Italia , Bressanone/Brixen 2008-10-07 - 2008-10-11
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Populærvitenskapelig foredragKrokan, Hans Einar. (2008) Tale ved mottakelse av Kong Olav V. kreftforskningspris for 2008. Den Norske Kreftforening Utdeling av Kong Olav V. Kreftforskningspris for 2008 , Oslo 2008-06-11 - 2008-06-11
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Populærvitenskapelig foredragKrokan, Hans Einar. (2008) Utsikt fra elfenbenstårnet. FUGE Midt-Norge Juleseminar FUGE Midt-Norge , Trondheim 2008-12-09 - 2008-12-09
2007
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Vitenskapelig foredragJakobsen, Caroline Hild; Bremseth, Hilde; Størvold, Gro Leite; Olsen, Karina Standahl; Follestad, Turid; Lundemo, Anne Gøril. (2007) DHA-induced growth inhibition of cancer cells is associated with disturbances in cholesterol metabolism, calcium homeostasis and induction of ER stress. Mikromatriseplattformen Foredrag i MOL8003 , Trondheim, NTNU 2007-03-27 - 2007-03-27
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Vitenskapelig foredrag