Hans Einar Krokan

Om

Short CV

BIOGRAPHICAL SKETCH

NAME		POSITION TITLE
Hans Einar Krokan		Professor/Chairman
EDUCATION/TRAINING
INSTITUTION AND LOCATION	DEGREE (if applicable)		YEAR(s)	FIELD OF STUDY
University of Oslo, Oslo, Norway	M.D		1970	Medicine
University of Tromsø, Tromsø, Norway	Ph.D.		1977	Biochemistry

A. Positions and Honors

Positions and Employment

1970-1972 Internship, in surgery, internal medicine and community medicine

1972 Doctor in the air force (captain), Ørlandet military airport

1972-1977 Research fellow, University of Tromsø, IMB

1977-1979 Post doctoral fellow (Fogarty International Fellowship), Harvard Medical School, Dep. Biol. Chem (18 months) with Prof. Melvin L. DePamphilis

1979-1985 Associate professor in biochemistry, University of Tromsø

1983-1984 Visiting scientist, (Stipend from International Cancer Union, Eleanor Roosevelt Awardee), National Cancer Institute, Lab. Human Carcinogenesis, Bethesda (12 months) with Dr. C. C. Harris

1985-1988 Department head, Department of biotechnology, Norsk Hydro Research Centre Porsgrunn, from 1987 Director of Research, Biomedical Section (responsible for biotechnology, organic chemistry and preclinical- and clinical medicine)

1988-1993 Professor at Institute of Biotechnology/UNIGEN, Scientific director of Unigen, University of Trondheim Norwegian College of Technology

1993-present Professor in medicine/molecular Biology, Medicine, Institute of Cancer Research and Molecular Biology)

1990-2002 Director/Chairman, Institute of Cancer Research and Molecular Biology, Faculty of Medicine, University of Trondheim

2006- Director/Chairman, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (formerly University of Trondheim)

2006- Norwegian delegate ESFRI (European Strategy Forum for Research Infrastructures) Biological and medical Road Map Working Group

Honors

1977-1979 Fogarty International Fellowship

1983 Eleanor Roosevelt Awardee

1994 Elected member of The Royal Norwegian Academy of Science and Letters

1997 Honorary member of the Norwegian Biochemical Society

2000 Elected member of the European Molecular Biology Organization (EMBO)

2004 Anders Jahre’s Award for Medical Research; “For his groundbreaking DNA research” (a prize given annually to one/two scientist(s) in the 5 Nordic countries).

2008 King Olav Vs Prize for Cancer Research

Research experience and interests:

Hans E. Krokan has established research groups within DNA replication, genome maintenance and DNA repair, omega-3 fatty acids research, and research on predisposition to lung cancer. He has also established extensive research programs in an industrial company (Norsk Hydro AS), and has successfully contributed to drug development, particularly Omacor, the only therapeutic drug developed in Norway. His research group within DNA repair is among the internationally leading groups.

B. Selected peer-reviewed publications (from approximately 150 scientific articles in international journals, mostly within DNA replication and DNA repair since 1975).

Krokan, H.E. and Wittwer, C. (1981) Uracil-DNA glycosylase: General properties substrate specificity and effect of uracil analogs. Nucleic Acids Res. vol. 5, 2599-2613.

Slupphaug, G., Olsen, L.C., Aasland, R., Helland, D.E. and Krokan, H.E. (1991). Cell cycle kinetics and hybrid arrest identifies a major uracil-DNA glycosylase. Nucl. Acids Res. 19, 5131-5137

Slupphaug, G., Markussen, F.H., Olsen, L.C., Aasland, R., Aarsæther, N., Bakke, O., Krokan, H.E. and Helland, D.E. and (1993). Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene. Nucl. Acids Res. 21, 2579-2584

Slupphaug, G., Eftedal, I., Kavli, B., Bharati, S., Helle, N., Haug, T., Levine, D.W. and Krokan, H.E. (1995) Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG-gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase. Biochemistry 34, 128-138

Mol, C.D., Arvai, A.S., Slupphaug, G., Kavli, B., Alseth, I., Krokan, H.E. and Tainer, J.A. (1995) Crystal Structure and mutational analysis of Human Uracil-DNA glycosylase: Structural basis for specificity and catalysis. Cell 80, 869-878

Mol, C.D., Arvai, A.S., Sanderson, R.J., Slupphaug, G., Kavli, B., Krokan, H.E., Mosbaugh, D.W. and Tainer, J.A. (1995). Crystal Structure of Human Uracil-DNA Glycosylase in Complex with a Protein Inhibitor. Cell 82, 701-708

Kavli, B., Slupphaug, G., Mol, C.D., Arvai, A.S., Petersen, S.B., Tainer, J.A., and Krokan, H.E. (1996). Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO J. 15, 3442-3447

Slupphaug, G., Kavli, B., Mol, C.D., Arvai, A., Krokan, H.E. and Tainer, J.A. (1996). Structure of human uracil-DNA glycosylase bound to DNA shows a nucleotide flipping mechanism. Nature 384, 87-92

Nagelhus, T., Haug, T., Singh, K.K., Keshav, K.F., Skorpen, F., Bharati, S., Otterlei, M., Lindmo, T., Benichou, S., Benarous, R. and Krokan, H.E. (1997). A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34 kDa subunit of replication protein A. J. Biol. Chem. 272, 6561-6566

Krokan, H.E., Standal, R. and Slupphaug,G (1997) DNA glycosylases in base excision repair. Biochem. J. 325, 1-16

Parikh, S.S., Mol, C.D., Slupphaug, G., Bharati, S., Krokan, H.E. and Tainer, J.A. (1998). Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase. EMBO J. 17, 5214-5226

Otterlei, M., Haug, T., Nagelhus, T.A., Slupphaug, G., Lindmo, T. and Krokan, H.E. (1998). Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively. Nucl. Acids Res. 20, 4611-4617

Otterlei, M., Warbrick, E., Slupphaug, G., Nagelhus, T.A., Haug, T., Akbari, M., Aas, P.A., Steinsbekk, K.,Bakke, O., and Krokan, H.E.(1999) Postreplicative Base Excision Repair in Replication Foci. EMBO J. 18, 3834-3844

Parikh, S., Walcher, G., Jones, G.D., Slupphaug, G., Krokan, H.E., Blackburn, G.M. and Tainer, J.A. (2000) Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proc. Natl. Acad. Sci., USA 97, 5083-5088

Otterlei, M., Kavli, B., Standal, R., Skjelbred, C., Bharati, S., Krokan, H.E. (2000). Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO J. 19, 5542-5551

Kavli, B., Sundheim, O., Akbari, M., Otterlei, M., Nilsen, H., Skorpen, F., Aas, P.A., Hagen, L., Krokan, H.E. and Slupphaug, G. (2002). hUNG2 is the major repair enzyme for removal of uracil from U:A matchers, U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. J. Biol. Chem. 277, 39926-39936.

Aas, P.A., Otterlei, M., Falnes, P.Ø., Vågbø, C.B., Skorpen, F., Akbari, M., Sundheim, O., Bjørås, M., Slupphaug, G., Seeberg, E. and Krokan, H.E. (2003). Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature 421; 859-863

Imai, K, Slupphaug, G., Lee,W-I., Revy, P., Nonoyama, S, Catalan, N, Yel, L., Forveille, M., Kavli, B., Krokan, H.E., Ochs, H.D., Fischer, A. and Durandy, A. (2003) Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch. Nature Immunology 4:1023-1028

Akbari, M., Otterlei, M., Peña-Diaz, J., Kavli, B., Hagen, L., Liabakk, N.B., Imai, K., Durandy, A., Slupphaug G., and Krokan, H.E. (2004) An affinity-isolated UNG2-associated repair complex carries out complete repair of U/G mispairs and U/A pairs in DNA. Nucl. Acids Res. 32:5486-98

Kavli, B., Andersen, S., Otterlei, M., Liabakk, N., Durandy A., Imai, K., Krokan H.E., and Slupphaug, G.(2005) Lymphoid cell lines from UNG deficient HIGM patients have profoundly impaired uracil excision activity from single stranded DNA and increased levels of uracil in the chromosome. J. Exp. Med. 201, 2011-2021

Andersen, S., Ericsson, M., Dai, HY, Peña-Diaz, J., Slupphaug, G., Nilsen, H., Aarset, H. and Krokan, H.E. (2005)Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair 4:1432-1441.

Auerbach, P., Bennett, A.O., Bailey, E., Krokan, H,E. and Demple, B. (2005) Mutagenic specificity of endogenously-generated abasic sites in Saccharomyces cerevisiae chromosomal DNA. Proc. Natl. Acad. Sci. USA..102:17711-17716.

Ringvoll,J., Nordstrand, L.M., Vågbø, C. B. Talstad, V., Reite,K., Aas, P.A., Lauritzen, K. H., Liabakk, N.B., Bjørk, A., Doughty, R.W., Falnes, P., Krokan, H.E. and Klungland, A. (2006) Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing endogenous and induced 1meA and 3meC lesions in DNA. EMBO J. 25:2189-2198.

Sundheim, O., Vågbø, C.V., Bjørås, de Sousa, M.M.L., Aas, P.A., Drabløs, Krokan, H.E., Tainer, J.A. and Slupphaug, G. (2006). Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO J. 25:3389-3397

Akbari, M., Otterlei, M., Peña-Diaz, J., and. Krokan, H.E. (2007) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience 6:505-516

Pettersen, H.S., Sundheim, O., Gilljam, K.; Slupphaug, G., Krokan, H.E. and Kavli, B. (2007) Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of Base Excision Repair by distinct mechanisms. Nucl. Acids. Res.35: 3879-3892.

Kavli, B., Otterlei, M., Slupphaug, G. and Krokan, H.E.(2007) DNA-General mutagen, but normal intermediate in acquired immunity. DNA Repair (Amst). 6:505-516

Hagen, L., Kavli, B., Sousa, M. M.L., Diaz, J.P., Liabakk, N.B., Aslaksen, P.B., Torseth, K., Sundheim, O., Otterlei, M., Hørning, O., Jensen, O.N., Krokan, H.E. and Slupphaug, G. (2008) Cell Cycle Regulated Phosphorylations of Human Uracil-DNA Glycosylase UNG2 Govern Replication-Associated Uracil Removal EMBO J. 27:51-61

Akbari, M., Visnes, T., Krokan, H.E. and Otterlei, M. (2008) Base excision repair by human mitochondrial extracts involves both single-nucleotide insertion and long-patch DNA synthesis. DNA Repair 7:605-616

Hung, R.J., McKay, J.D., Gaborieau, V., Boffetta, P., Hashibe, M., Earidze, D., …Krokan, H.E.,… Lathrop, M., Brennan, P. (2008) A genome-wide association study identifies a susceptibility locus for lung cancer encompassing nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452:633-637(multicenter study with 6 centers, several author names deleted to save space)

Westbye, M.P., Feyzi, E., Aas, P.A., Vågbø, C.B., Kavli, B., Talstad, V.A., Hagen, L., Sundheim, O., Liabakk, N-B., Slupphaug, G., Otterlei, M., Krokan, H.E.(2008) Human AlkB homologue 1 is a mitochondrial protein that repairs 3-methylcytosine in DNA. J Biol Chem 283:25046-25056

McKay, J.D., Hung, R.J. , Gaborieau, V., Boffetta^,P., (authors deleted), Krokan, H.E., Skorpen, F., Elvestad, M.B., Vatten, L.,…(authors deleted) Lathrop, M., Brennan, P. (2008)Identification of gene region 5p15.33, comprising the telomerase reverse transcriptase gene, as a novel lung cancer susceptibility locus among 6,000 lung cancer cases and 9,500 controls. Nature Genetics 40:1404-1406 (multicenter study with 6 centers, several author names deleted to save space)

Sundheim, O., Talstad, V.A., Vågbø, C.B., Slupphaug, G., Krokan, H.E. (2008) AlkB demethylases flip out in different ways. DNA Repair 7:1916-1923

Visnes, T., Doseth, B., Pettersen, H.S., Hagen, L., Sousa, MML, Akbari, M., Otterlei, M., Kavli, B., Slupphaug, G., and Krokan, H.E. (2009) Uracil in DNA and its processing by different DNA glycosylases. Royal Phil. Transact. B. 364:563-568

Publikasjoner

2023

Lefol, Yohan Pierre; Korfage, Tom; Mjelle, Robin; Prebensen, Christian Haugland; Lüders, Torben; Müller, Bruno; Krokan, Hans Einar; Sarno, Antonio; Alsøe, Lene; Berdal, Jan-Erik. (2023) TiSA: TimeSeriesAnalysis - A pipeline for the analysis of longitudinal transcriptomics data. NAR Genomics and Bioinformatics
Vitenskapelig artikkel

2022

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra; Gustafsson, Robert; Wiita, Elisée; Borhade, Sanjay; Green, Alanna C.; Vallin, Karl S. A.; Sarno, Antonio. (2022) Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nature Cancer
Vitenskapelig artikkel

2021

Olinski, Ryszard; Slupphaug, Geir; Foksinski, Marek; Krokan, Hans Einar. (2021) Genomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignancies. International Journal of Molecular Sciences
Vitenskapelig artikkel

2020

Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2020) Genomic Uracil in Biology, Immunity and Cancer.
Vitenskapelig kapittel
Boeckemeier, L; Kraehenbuehl, R; Keszthelyi, A; Gasasira, MU; Vernon, EG; Beardmore, R; Vågbø, Cathrine Broberg; Chaplin, D; Gollins, S; Krokan, Hans Einar. (2020) Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication. Science Advances
Vitenskapelig artikkel
Visnes, Torkild; Benitez-Buelga, Carlos; Cázares-Körner, Armando; Sanjiv, Kumar; Hanna, Bishoy M F; Mortusewicz, Oliver; Rajagopal, Varshni; Albers, Julian J.; Hagey, Daniel W.; Bekkhus, Tove. (2020) Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Research (NAR)
Vitenskapelig artikkel

2019

Sarno, Antonio; Lundbæk, Marie Benner; Liabakk, Nina-Beate; Aas, Per Arne; Mjelle, Robin; Hagen, Lars; Sousa, Mirta; Krokan, Hans Einar; Kavli, Bodil Merete. (2019) Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil. Nucleic Acids Research (NAR)
Vitenskapelig artikkel

2018

Krokan, Hans Einar; Kavli, Bodil Merete; Sarno, Antonio; Slupphaug, Geir. (2018) Enzymology of Genomic Uracil Repair.
Faglig kapittel
Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil – Valuable Tool in Molecular Biology but Inherent Problem in Sequencing of Ancient DNA.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir; Drabløs, Finn. (2018) The Earth, Life and Genomic Uracil.
Faglig kapittel
Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil - Evolution, Biology, Immunology and Disease. World Scientific
Faglig monografi
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) DNA Repair is Integrated with Many Cellular Processes.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) Viral Uracil - Uracil DNA glycosylases and dUTPases.
Faglig kapittel
Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2018) Routes to Uracil in DNA.
Faglig kapittel
Visnes, Torkild; Armando, Cazares-Körner; Wenjing, Hao; Wallner, Olov; Masuyer, Geoffrey; Loseva, Olga; Mortusewicz, Oliver; Wiita, Elisee; Sarno, Antonio; Manoilov, Aleksandr. (2018) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science
Vitenskapelig artikkel

2017

Krokan, Hans Einar; Slupphaug, Geir; Kavli, Bodil Merete. (2017) Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig kapittel
Wang, Yufei; McKay, James D.; Rafnar, Thorunn; Wang, Zhaoming; Timofeeva, Maria N.; Broderick, Peter; Zong, Xuchen; Laplana, Marina; Wei, Yongyue; Han, Younghun. (2017) Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer (Nature Genetics (2014) 46 (736-741)). Nature Genetics
Korrigendum
Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix; Lirussi, Lisa; SenGupta, Tanima; Tekin, Nuriye Basdag; Jobert, Laure; Alexandrov, Ludmil B.. (2017) Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. Scientific Reports
Vitenskapelig artikkel

2016

Xue, JH; Xu, GF; Gu, TP; Chen, GD; Han, BB; Xu, ZM; Bjørås, Magnar; Krokan, Hans Einar; Xu, GL; Du, Yr. (2016) Uracil-DNA glycosylase UNG promotes tet-mediated DNA demethylation. Journal of Biological Chemistry
Vitenskapelig artikkel
Helander, Linda; Sharma, Animesh; Krokan, Hans Einar; Plaetzer, Kristjan; Krammer, Barbara; Tortik, Nicole; Gederaas, Odrun Arna; Slupphaug, Geir; Hagen, Lars. (2016) Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins. Molecular Biosystems
Vitenskapelig artikkel
Robles, Ana I.; Olsen, Karina Standahl; Tsui, Dana W.T.; Georgoulias, Vassilis; Creaney, Jenette; Dobra, Katalin; Vyberg, Mogens; Minato, Nagahiro; Anders, Robert A.; Børresen-Dale, Anne-Lise. (2016) Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway. Journal of Translational Medicine
Vitenskapelig artikkel
Rasmussen, Erik; Vågbø, Cathrine Broberg; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne; Amdam, Gro Vang; Dahl, John Arne. (2016) DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates. Biochemistry and Biophysics Reports
Vitenskapelig artikkel

2015

Mjelle, Robin; Hegre, Siv Anita; Aas, Per Arne; Slupphaug, Geir; Drabløs, Finn; Sætrom, Pål; Krokan, Hans Einar. (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair
Vitenskapelig artikkel
Helander, Linda; Krokan, Hans Einar; Gederaas, Odrun Arna; Johnsson, Anders Carl G.; Chen, Duan. (2015) Hexylaminolevulinate Photodynamic Treatment of Cancer Cell Lines. PhD Thesis. Tapir Akademisk Forlag
Doktoravhandling
Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål. (2015) AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA Repair
Vitenskapelig artikkel
Brenner, Darren. R.; Amos, Christopher I.; Brhane, Yonathan; Timofeeva, Maria N.; Caporaso, Neil; Wang, Yufei; Christiani, David C.; Bickeböller, Heike; Yang, Ping; Albanes, Demetrius. (2015) Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. Carcinogenesis
Vitenskapelig artikkel

2014

Wang, Yufei; McKay, JD; Rafnar, T; Wang, Z; Timofeeva, MN; Broderick, P; Zong, X; Laplana, M; Wei, Y; Han, Y. (2014) Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nature Genetics
Vitenskapelig artikkel
Krokan, Hans Einar; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Kavli, Bodil Merete; Slupphaug, Geir. (2014) Error-free versus mutagenic processing of genomic uracil-Relevance to cancer. DNA Repair
Vitenskapelig artikkel
Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin. (2014) Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLOS ONE
Vitenskapelig artikkel
Helander, Linda; Krokan, Hans Einar; Johnsson, Anders Carl G.; Gederaas, Odrun Arna; Plaetzer, Kristjan. (2014) Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro. Journal of Biomedical Optics
Vitenskapelig artikkel
Wallenius, Anders; Hauser, Jannek; Aas, Per Arne; Sarno, Antonio; Kavli, Bodil Merete; Krokan, Hans Einar; Grundström, Thomas. (2014) Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification. Molecular Immunology
Vitenskapelig artikkel
Hu, Yi; Ericsson, Ida; Doseth, Berit; Liabakk, Nina-Beate; Krokan, Hans Einar; Kavli, Bodil Merete. (2014) Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors. Experimental Cell Research
Vitenskapelig artikkel

2013

Hu, Yi; Ericsson, Ida; Torseth, Kathrin; Methot, Stephen; Sundheim, Ottar; Liabakk, Nina-Beate; Slupphaug, Geir; Noia, Javier Di; Krokan, Hans Einar; Kavli, Bodil Merete. (2013) A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching. Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
Krokan, Hans Einar; Bjørås, Magnar. (2013) Base Excision Repair. Cold Spring Harbor Perspectives in Biology
Vitenskapelig artikkel
Diaz, Javier Pena; Hegre, Siv Anita; Anderssen, Endre; Aas, Per Arne; Mjelle, Robin; Gilfillan, Gregor Duncan; Lyle, Robert; Drabløs, Finn; Krokan, Hans Einar; Sætrom, Pål. (2013) Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Hegre, Siv Anita; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Otterlei, Marit; Krokan, Hans Einar. (2013) Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase. DNA Repair
Vitenskapelig artikkel
Overland, Hilde Bremseth; Schønberg, Svanhild Margrethe Arentz; Krokan, Hans Einar. (2013) ER stress, reactive oxygen species and autophagy in colon cancer cells treated with polyunsaturated marine fatty acids. Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fedorcsak, Peter; Huang, Chun-Min; Li, Charles J.; Vågbø, Cathrine Broberg; Shi, Yue; Wang, Wen-Ling; Song, Shu-Hui. (2013) ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Molecular Cell
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Ericsson, Ida; Galashevskaya, Anastasia; Sarno, Antonio; Aas, Per Arne; Vagbo, CB; Pettersen, Henrik P Sahlin; Slupphaug, Geir. (2013) Genomic uracil - potent mutagen but normal intermediate in adaptive immunity. The FEBS Journal
Konferanseabstract
Gabrielsen, Maiken Elvestad; Romundstad, Pål Richard; Langhammer, Arnulf; Krokan, Hans Einar; Skorpen, Frank. (2013) Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway. European Journal of Human Genetics
Vitenskapelig artikkel
Bjørngaard, Johan Håkon; Gunnell, David; Gabrielsen, Maiken Elvestad; Smith, George Davey; Skorpen, Frank; Krokan, Hans Einar; Vatten, Lars Johan; Romundstad, Pål Richard. (2013) The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study. Psychological Medicine
Vitenskapelig artikkel
Galashevskaya, Anastasia; Sarno, Antonio; Vågbø, Cathrine Broberg; Aas, Per Arne; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2013) A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported. DNA Repair
Vitenskapelig artikkel

2012

Kazma, R; Babron, MC; Gaborieau, Valerie; Génin, E; Brennan, P; Hung, Rayjean J.; McLaughlin, Jon; Krokan, Hans Einar; Gabrielsen, Maiken Elvestad; Skorpen, Frank. (2012) Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. Carcinogenesis
Vitenskapelig artikkel
Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne; Grini, Paul Eivind; Falnes, Pål. (2012) The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Johnson, Matthew P; Brennecke, Shaun P.; Iversen, Ann-Charlotte; East, Christine; Olsen, Guro Dalheim; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Abraham, Lawrence J. (2012) Genome-wide association scans identify novel maternal susceptibility loci for preeclampsia. Pregnancy Hypertension
Konferanseabstract
Akbari, Mansour; Krokan, Hans Einar. (2012) Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-Implications for comparative studies. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Vitenskapelig artikkel
Krokan, Hans Einar. (2012) A life in DNA repair-And beyond. DNA Repair
Leder
Torseth, Kathrin; Doseth, Berit; Hagen, Lars; Olaisen, Camilla; Liabakk, Nina-Beate; Græsmann, Heidi; Durandy, Anne; Otterlei, Marit; Krokan, Hans Einar; Kavli, Bodil Merete. (2012) The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA. DNA Repair
Vitenskapelig artikkel
Doseth, Berit; Ekre, Cecilie; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2012) Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil. DNA Repair
Vitenskapelig artikkel
Krokan, Hans Einar. (2012) The Essentials of DNA Repair. Public Service Review: European Union
Populærvitenskapelig artikkel
Timofeeva, MN; Hung, RJ; Rafnar, T; Christiani, DC; Field, JK; Bickeboller, H; Risch, A; McKay, JD; Wang, Y; Dai, J. (2012) Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Human Molecular Genetics
Vitenskapelig artikkel
Krokan, Hans Einar. (2012) Stable Genomes and DNA Repair. International Innovation
Populærvitenskapelig artikkel
Krokan, Hans Einar. (2012) To Repair and Protect. International Innovation
Populærvitenskapelig artikkel
Vågbø, Cathrine Broberg; Svaasand, Eva Kathrine; Aas, Per Arne; Krokan, Hans Einar. (2012) Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response. DNA Repair
Vitenskapelig artikkel

2011

Robertson, Adam Brian; Dahl, John Arne; Vågbø, Cathrine Broberg; Tripathi, P; Krokan, Hans Einar; Klungland, Arne. (2011) A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Sletta, Håvard; Klinkenberg, Geir; Winnberg, Asgeir; Kvitvang, Hans Fredrik Nyvold; Nilsen, Marianne Bakke; Krokan, Hans Einar; Otterlei, Marit; Bruheim, Per. (2011) A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants. Journal of Microbiological Methods
Vitenskapelig artikkel
Baglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda; Zub, Kamila; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Photochemical and Photobiological Sciences
Vitenskapelig artikkel
Leihne, VIbeke; Kirpekar, F; Vågbø, Cathrine Broberg; Van den Born, Erwin; Krokan, Hans Einar; Grini, Paul Eivind; Meza, Trine Johansen; Falnes, Pål. (2011) Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Hanssen-Bauer, Audun; Garten, Karin Solvang-; Sundheim, Ottar; Diaz, Javier Pena; Andersen, Sonja Benedikte; Slupphaug, Geir; Krokan, Hans Einar; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2011) XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage. Environmental and Molecular Mutagenesis
Vitenskapelig artikkel
Doseth, Berit; Visnes, Torkild; Wallenius, Anders; Ericsson, Ida; Sarno, Antonio; Pettersen, Henrik Sahlin; Flatberg, Arnar; Catterall, Tara Cherie; Slupphaug, Geir; Krokan, Hans Einar. (2011) Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE. Journal of Biological Chemistry
Vitenskapelig artikkel
Arum, Carl-Jørgen; Gederaas, Odrun Arna; Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Hjelde, Astrid; Krokan, Hans Einar; Svaasand, Lars O.; Chen, Duan; Zhao, Chun-Mei. (2011) Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action. Journal of Biomedical Optics
Vitenskapelig artikkel
Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor; Leszczynska, G; Malkiewicz, A; Krokan, Hans Einar; Kirpekar, F; Klungland, Arne. (2011) ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications
Vitenskapelig artikkel

2010

Monsen, Vivi A Talstad; Krokan, Hans Einar; Aas, Per Arne. (2010) Mechanisms of alkylation damage repair by human AlkB homologues. Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
Monsen, Vivi A Talstad; Sundheim, Ottar; Aas, Per Arne; Westbye, Marianne Pedersen; Sousa, Mirta; Slupphaug, Geir; Krokan, Hans Einar. (2010) Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Songe-Møller, Lene; Van den Born, Erwin; Leihne, V; Vågbø, Cathrine Broberg; Kristoffersen, T; Krokan, Hans Einar; Kirpekar, F; Falnes, PO; Klungland, A. (2010) Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding. Molecular and Cellular Biology
Vitenskapelig artikkel
Slagsvold, Jens Erik; Pettersen, Caroline Hild; Størvold, Gro Leite; Follestad, Turid; Krokan, Hans Einar; Schønberg, Svanhild Margrethe Arentz. (2010) DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells. Nutrition and Cancer
Vitenskapelig artikkel
Akbari, Mansour; Garten, Karin Solvang-; Hanssen-Bauer, Audun; Lieske, Nora V.; Pettersen, Henrik P Sahlin; Pettersen, Grete Klippenvåg; Wilson, DM; Krokan, Hans Einar; Otterlei, Marit. (2010) Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair
Vitenskapelig artikkel
Krokan, Hans Einar; Kavli, Bodil Merete; Otterlei, Marit; Akbari, M.; Slupphaug, Geir; Aas, Per Arne. (2010) DNA repair and cancer. European Journal of Cancer
Konferanseabstract

2009

Akbari, Mansour; Diaz, Javier Pena; Andersen, Sonja Benedikte; Liabakk, Nina-Beate; Otterlei, Marit; Krokan, Hans Einar. (2009) Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity. DNA Repair
Vitenskapelig artikkel
Landi, MT; Chatterjee, N; Yu, K; Goldin, LR; Goldstein, AM; Rotunno, M; Mirabello, L; Jacobs, K; Jacobs, K; Wheeler, W. (2009) A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma. American Journal of Human Genetics
Vitenskapelig artikkel
Aas, Per Arne; Diaz, Javier Pena; Liabakk, Nina-Beate; Krokan, Hans Einar; Skorpen, Frank. (2009) Overexpression of transcription factor AP-2 stimulates the P-A promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression. DNA Repair
Vitenskapelig artikkel
Slagsvold, Jens Erik; Pettersen, Caroline Hild; Follestad, Turid; Krokan, Hans Einar; Schønberg, Svanhild Margrethe Arentz. (2009) The Antiproliferative Effect of EPA in HL60 Cells is Mediated by Alterations in Calcium Homeostasis. Lipids
Vitenskapelig artikkel
Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology
Vitenskapelig artikkel
Krokan, Hans Einar; Visnes, Torkild. (2009) DNA Excision repair of uracil and 5-fluorouracil in human cancer cell lines. Det medisinske fakultet, NTNU
Doktoravhandling
Størvold, Gro Leite; Fleten, Karianne Giller; Olsen, Cathrine Goberg; Follestad, Turid; Krokan, Hans Einar; Schønberg, Svanhild Margrethe Arentz. (2009) Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells. Lipids
Vitenskapelig artikkel
Visnes, Torkild; Doseth, Berit; Pettersen, Henrik Sahlin; Hagen, Lars; Sousa, Mirta; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2009) Uracil in DNA and its processing by different DNA glycosylases. Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel

2008

Akbari, Mansour; Visnes, Torkild; Krokan, Hans Einar; Otterlei, Marit. (2008) Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis. DNA Repair
Vitenskapelig artikkel
Andersen, Sonja Benedikte; Krokan, Hans Einar; Baar, Cecilie Christensen; Rakvag, Trude Teoline; Laugsand, Eivor Alette; Kvam, Tor-Morten; Torill, Fladvad; Skorpen, Frank. (2008) Identification of an alternative, putative promoter and new alternatively spliced transcripts from the human µ opioid receptor gene, OPRM1. Palliative Medicine
Konferanseabstract
Sundheim, Ottar; Talstad, Vivi A; Vågbø, Cathrine Broberg; Slupphaug, Geir; Krokan, Hans Einar. (2008) AlkB demethylases flip out in different ways. DNA Repair
Vitenskapelig artikkel
Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry
Vitenskapelig artikkel
Visnes, Torkild; Akbari, Mansour; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2008) The rate of base excision repair of uracil is controlled by the initiating glycosylase. DNA Repair
Vitenskapelig artikkel
Krokan, Hans Einar. (2008) NBS 40 år. NBS-nytt
Populærvitenskapelig artikkel
McKay, JD; Mckay, JD; Hung, RJ; Gaborieau, V; Boffetta, Paolo; Chabrier, Amelie; Byrnes, GB; Zaridze, D; Mukeria, A; Szeszenia-Dabrowska, N. (2008) Lung cancer susceptibility locus at 5p15.33. Nature Genetics
Vitenskapelig artikkel
Hung, RJ; Mckay, JD; Gaborieau, V; Boffetta, P; Hashibe, M; Zaridze, D; Mukeria, A; Szeszenia-Dabrowska, N; Lissowska, J; Rudnai, P. (2008) A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature
Vitenskapelig artikkel
Heath, SC; Gut, IG; Brennan, P; Mckay, JD; Bencko, V; Fabianova, E; Foretova, L; Georges, M; Janout, V; Kabesch, M. (2008) Investigation of the fine structure of European populations with applications to disease association studies. European Journal of Human Genetics
Vitenskapelig artikkel
Slagsvold, Jens Erik; Pettersen, Caroline Hild; Follestad, Turid; Krokan, Hans Einar; Schønberg, Svanhild Margrethe Arentz. (2008) The antiproliferative effect of EPA in HL60 cells is mediated by alterations in calcium homeostasis. Lipids
Vitenskapelig artikkel
Akbari, Mansour; Krokan, Hans Einar. (2008) Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging. Mechanisms of Ageing and Development
Vitenskapelig oversiktsartikkel
Hung, RJ; Mckay, J; Gaborieau, V; Boffetta, P; Chu, C; Field, JK; Krokan, Hans Einar; Vineis, P; Larthrop, M; Brennan, P. (2008) Detecting new genes for tobacco-related cancers - genomewide association study of lung cancer. European Journal of Cancer
Konferanseabstract
Bathen, Tone Frost; Holmgren, Kristin; Lundemo, Anne Gøril; Hjelstuen, Mari H; Krokan, Hans Einar; Gribbestad, Ingrid S; Schønberg, Svanhild Margrethe Arentz. (2008) Omega-3 Fatty Acids Supress Growth of SW620 Human Colon Cancer Xenografts in Nude Mice. Anticancer Research
Vitenskapelig artikkel
Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Liabakk, Nina-Beate; Sundheim, Ottar; Diaz, Javier Pena; Otterlei, Marit; Hørning, Ole; Jensen, Ole N. (2008) Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO Journal
Vitenskapelig artikkel
Jakobsen, CH; Pettersen, Caroline Hild; Størvold, Gro Leite; Bremseth, Hilde; Follestad, Turid; Sand, Kristin; Mack, Merete; Olsen, Karina Standahl; Lundemo, Anne Gøril; Iversen, Jens Gustav. (2008) DHA induces ER stress and growth arrest in human colon cancer cells: association with cholesterol and calcium homeostasis. Journal of Lipid Research
Vitenskapelig artikkel
Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Gederaas, Odrun Arna; Arum, Carl-Jørgen; Hjelde, Astrid; Zhao, Chun-Mei; Chen, Duan; Krokan, Hans Einar; Svaasand, Lars O.. (2008) Monitoring of Hexyl 5-aminolevulinate Induced Photodynamic Therapy in Rat Bladder Cancer by Optical Spectroscopy. Journal of Biomedical Optics
Vitenskapelig artikkel

2007

Akbari, Mansour; Otterlei, Marit; Pena-Diaz, J; Krokan, Hans Einar. (2007) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience
Vitenskapelig artikkel
Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel
Sousa, Mirta; Krokan, Hans Einar; Slupphaug, Geir. (2007) DNA-uracil and human pathology. Molecular Aspects of Medicine
Vitenskapelig oversiktsartikkel
Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) Uracil in DNA - General mutagen, but normal intermediate in acquired immunity. DNA Repair
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA- from molecular biology to phenotype. DNA Repair
Konferanseabstract
Krokan, Hans Einar; Kavli, Bodil Merete; Akbari, Mansour; Visnes, Torkild; Pettersen, Henrik P Sahlin; Sundheim, Ottar; Hagen, Lars; Otterlei, Marit; Gilljam, Karin Margaretha; Slupphaug, Geir. (2007) Repair og uracil in DNA by UNG2 and SMUG1 - an update. DNA Repair
Konferanseabstract
Pettersen, Henrik P Sahlin; Sundheim, Ottar; Gilljam, Karin Margaretha; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2007) Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Gederaas, Odrun Arna; Krokan, Hans Einar; Hjelme, Dag Roar; Svaasand, Lars O.. (2007) In vitro study on methemoglobin formation in erythrocytes following hexyl-aminolevulinate induced photodynamic therapy.
Vitenskapelig kapittel
Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA - From molecular biology to phenotype - Preface. DNA Repair
Leder

2006

Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Krokan, Hans Einar. (2006) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2006) Preface. DNA Repair
Vitenskapelig artikkel
Hagen, Lars; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2006) Genomic uracil and human disease. Experimental Cell Research
Vitenskapelig oversiktsartikkel
Ringvoll, Jeanette; Ringvoll, Jeanette; Nordstrand, Line M.; Vågbø, Cathrine Broberg; Vagbo, CB; Talstad, Vivi; Reite, Karen; Aas, Per Arne; Lauritzen, Knut H.; Liabakk, Nina-Beate. (2006) Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO Journal
Vitenskapelig artikkel
Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Mittelstedt, L.Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO Journal
Vitenskapelig artikkel
Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Gederaas, Odrun Arna; Arum, Carl-Jørgen; Krokan, Hans Einar; Chen, Duan; Hjelme, Dag Roar; Svaasand, Lars O.. (2006) Monitoring of hALA induced PDT in rat bladder cancer by optical spectroscopy. Lasers in Surgery and Medicine
Konferanseabstract
Krokan, Hans Einar; Akbari, Mansour; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Ericsson, Madelene; Aarset, Harald; Andersen, Sonja Benedikte; Slupphaug, Geir. (2006) Base excision repair proteins in cancer prevention and acquired immune responses. The FEBS Journal
Konferanseabstract
Schønberg, Svanhild Margrethe Arentz; Lundemo, Anne Gøril; Fladvad, Torill; Holmgren, Kristin; Bremseth, Hilde; Nilsen, Asbjørn Magne; Gederaas, Odrun Arna; Tvedt, Kåre E; Egeberg, Kjartan Wøllo; Krokan, Hans Einar. (2006) Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1. The FEBS Journal
Vitenskapelig artikkel

2005

Akbari, Mansour; Hansen, Marianne Dore; Halgunset, Jostein; Skorpen, Frank; Krokan, Hans Einar. (2005) Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner. Journal of Molecular Diagnostics
Vitenskapelig artikkel
Hjelde, Astrid; Gederaas, Odrun Arna; Krokan, Hans Einar; Brubakk, Alf O. (2005) Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines. Medical Science Monitor
Vitenskapelig artikkel
Andersen, S; Heine, T; Sneve, Ragnhild; Konig, I; Krokan, HE; Epe, B; Nilsen, Hilde. (2005) Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis
Vitenskapelig artikkel
Andersen, S; Ericsson, M; DAI, H; Peña-Diaz, J; Slupphaug, G; Nilsen, Hilde; Aarset, H; Krokan, HE. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair
Vitenskapelig artikkel
Schønberg, Svanhild Margrethe Arentz; Jakobsen, Caroline Hild; Bremseth, Hilde; Olsen, Karina Standahl; Lundemo, Anne Gøril; Follestad, Turid; Sand, Kristin; Iversen, Jens Gustav; Krokan, Hans Einar. (2005) Endoplasmic reticulum stress induced by DHA leads to growth arrest of human colon cancer cells. Chemistry and Physics of Lipids
Vitenskapelig artikkel
Kavli, Bodil Merete; Andersen, Sonja Benedikte; Otterlei, Marit; Liabakk, Nina-Beate; Imai, K; Fischer, A; Durandy, A; Krokan, Hans Einar; Slupphaug, Geir. (2005) B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Journal of Experimental Medicine (JEM)
Vitenskapelig artikkel
Andersen, Sonja Benedikte; Ericsson, Maria Elisabeth Madelene; Dai, HY; Diaz, Javier Pena; Slupphaug, Geir; Nilsen, H; Aarset, H; Krokan, Hans Einar. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair
Vitenskapelig artikkel
Andersen, Sonja Benedikte; Heine, T; Sneve, Ragnhild; Kønig, Imbritt; Krokan, Hans Einar; Epe, B; Nilsen, Hilde. (2005) Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis
Vitenskapelig artikkel
Gederaas, Odrun Arna; Schønberg, Svanhild Margrethe Arentz; Ramstad, Ståle; Berg, Kristian; Johnsson, Anders Carl G.; Krokan, Hans Einar. (2005) Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. Photochemical and Photobiological Sciences
Vitenskapelig artikkel
Auerbach, Paul; Bennett, Richard A.O.; Bailey, Elisabeth A.; Krokan, Hans Einar; Demple, Bruce. (2005) Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
Rakvag, Trude Teoline; Klepstad, Pål; Baar, Cecilie Christensen; Kvam, Tor-Morten; Dale, Ola; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2005) The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain
Vitenskapelig artikkel

2004

Klepstad, Pål; Rakvag, TT; Kaasa, Stein; Holthe, Monica; Dale, Ola; Borchgrevink, Petter Chr.; Baar, Cecilie Christensen; Vikan, T; Krokan, Hans Einar; Skorpen, Frank. (2004) The 118 A>G polymorphism in the human mu-opioid receptor gene may increase morphins requirements in patients with pain caused by malignant disease. Acta Anaesthesiologica Scandinavica
Vitenskapelig artikkel
Kvam, TM; Baar, Cecilie Christensen; Raakvag, Trude Teoline; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2004) Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing. Journal of Molecular Medicine
Vitenskapelig artikkel
Akbari, M; Skjelbred, C; Folling, I; Sagen, Jørn V.; Krokan, HE. (2004) A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA (Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss. Scandinavian Journal of Clinical and Laboratory Investigation
Vitenskapelig artikkel
Akbari, M; Skjelbred, C; Følling, Ivar; Sagen, J; Krokan, H E. (2004) A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA Leu (UUR)) applied to a Norwegian family with diabetes mellitus and hearing loss. Scandinavian Journal of Clinical and Laboratory Investigation
Vitenskapelig artikkel
Klepstad, Pål; Rakvag, Trude Teoline; Kaasa, Stein; Holthe, Monica; Dale, Ola; Borchgrevink, Petter Chr.; Baar, Cecilie Christensen; Krokan, Hans Einar; Skorpen, Frank. (2004) The 118 A>G polymorphism in the human µ-opioidreceptor gene may increase morphine requrements in patients with pain caused by malignant disease. Acta Anaesthesiologica Scandinavica
Vitenskapelig artikkel
Krokan, Hans Einar. (2004) Molecular and functional interactions in macromolecular repair. European Journal of Biochemistry (EJB)
Konferanseabstract
Diaz, Javier Pena; Akbari, Mansour; Sundheim, Ottar; Farez-Vidal, ME; Andersen, S; Sneve, R; Gonzalez-Pacanowska, D; Krokan, Hans Einar; Slupphaug, Geir. (2004) Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair. Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
Akbari, Mansour; Skjelbred, C; Folling, I; Sagen, J; Krokan, Hans Einar. (2004) A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss. Scandinavian Journal of Clinical and Laboratory Investigation
Vitenskapelig artikkel
Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Aas, Per Arne; Kavli, Bodil; Liabakk, Nina-Beate; Hagen, Lars; Imai, K; Durandy, A; Slupphaug, Geir. (2004) Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair
Vitenskapelig oversiktsartikkel
Krokan, Hans Einar; Slupphaug, Geir. (2004) Novel aspects of macromolecular repair and relationship to human disease. Journal of Molecular Medicine
Vitenskapelig oversiktsartikkel

2003

Holthe, M.; Rakvåg, Trude Teoline; Klepstad, Pål; Idle, Jefrrey R.; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2003) Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. The Pharmacogenomics Journal
Vitenskapelig artikkel
Holthe, Monica; Råkvåg, Trude Teoline; Klepstad, Pål; Idle, Jefrrey R.; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2003) Identification of 10 novel single nucleotide polymorphisms and analysis of their relevance to morphine glucuronidation. The Pharmacogenomics Journal
Vitenskapelig artikkel
Slupphaug, Geir; Kavli, Bodil; Krokan, Hans Einar. (2003) Interacting pathways that prevent and repair oxidative DNA damage. Mutation Research (DNA Repair)
Vitenskapelig artikkel
Imai, K; Slupphaug, Geir; Lee, W-I; Revy, P; Nonoyama, S; Catalan, N; Yel, L; Forveille, M; Kavli, Bodil; Krokan, Hans Einar. (2003) Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch. Nature Immunology
Vitenskapelig artikkel
Nilsen, Hilde; Stamp, G; Andersen, Sonja; Hrivnak, G; Krokan, Hans Einar; Lindahl, T; Barnes, D.E. (2003) Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene
Vitenskapelig artikkel
Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature
Vitenskapelig artikkel

2002

Holthe, Monica; Klepstad, Pål; Zahlsen, Kolbjørn; Borchgrevink, Petter Chr.; Hagen, Lars; Dale, Ola; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2002) Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1a1*28 polymorphisms in cancer patients on chronic morphine therapy. European Journal of Clinical Pharmacology
Vitenskapelig artikkel
Grøsvik, K; Slupphaug, Geir; Krokan, Hans Einar. (2002) "Characterisation of uracil-exising enzyme activities in organ extracts from UNG knockout and wild-type mice.". NTNU
Masteroppgave
Nygård, M; Nilsen, M; Remseth, V; Slupphaug, Geir; Krokan, Hans Einar. (2002) Uttrykk av det membran-modifiserende enzymet UDPDG i E.coli som funksjon av dyrkningsbetingelser og induksjon av DNA-skader. [Mangler utgivernavn]
Masteroppgave
Krokan, Hans Einar. (2002) Fromprotein folding to new enzymes. Tidsskrift for Den norske legeforening (Tidsskriftet)
Vitenskapelig artikkel
Holthe, Monica; Råkvåg, Trude Teoline; Klepstad, Pål; Idle, Jefrrey R.; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2002) Sequence variationin the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphins (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. The Pharmacogenomics Journal
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2002) Damage and repair of DNA in mammalian cells-emphasis on oxidative damage. Proceedings from International Symposium "Natural Ionising Radiation and Health". Det Norske Videnskaps-Akademi : proceedings
Vitenskapelig artikkel
Krokan, Hans Einar; Drabløs, Finn; Slupphaug, Geir. (2002) Uracil in DNA, occurrence, consequences and repair. Oncogene
Vitenskapelig artikkel
Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Skorpen, Frank; Aas, Per Arne; Hagen, Lars; Krokan, Hans Einar; Slupphaug, Geir. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry
Vitenskapelig artikkel

2001

Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Skjelbred, Camilla Furu; Akbari, Mansour; Aas, Per Arne; Slupphaug, Geir. (2001) Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
Krokan, Hans Einar. (2001) Biologiens århundre er nå. Fondsfinans Farmasi - Bioteknologi, Årsrapport 2000
Populærvitenskapelig artikkel
Dusseau, C.; Murray, GI; Keenan, RA; OKelly, T.; Krokan, Hans Einar; McLeod, HL. (2001) Analysis of uracil DNA glycosylase in human colorectal cancer. International Journal of Oncology
Vitenskapelig artikkel
Kvaløy, Kirsti; Nilsen, H.; Steinsbekk, Kristin; Nedal, Aina; Monterotti, Bruno; Akbari, Mansour; Krokan, Hans Einar. (2001) Sequence variation in the human uracil-DNA glycosylase (UNG) gene. Mutation Research (DNA Repair)
Vitenskapelig artikkel
Krokan, Hans Einar; Prydz, H.. (2001) Genoverføring - administrasjonsmåter, fordeler, mulige ulemper og farer. Tidsskrift for Den norske legeforening (Tidsskriftet)
Vitenskapelig artikkel
Rudra, Parveen; Krokan, Hans Einar. (2001) Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid. Anticancer Research
Vitenskapelig artikkel
Krokan, Hans Einar; Prydz, H.. (2001) Genoverføring - administrasjonsmåter, fordeler, mulige ulemper og farer. Tidsskrift for Den norske legeforening (Tidsskriftet)
Vitenskapelig artikkel
Prydz, Hans Peter B; Krokan, Hans E.. (2001) Genoverføring - Administrasjonsmåter, fordeler, mulige ulemper og farer. TDNLF
Vitenskapelig artikkel
Krokan, Hans Einar. (2001) Kong Olav V's kreftforskningspris til Erling Seeberg. NBS-nytt
Populærvitenskapelig artikkel
Krokan, Hans Einar; Nilsen, Hilde. (2001) Base excision repair in a network of defence and tolerance. Carcinogenesis
Vitenskapelig artikkel

2000

Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Parikh, Sudip S.; Walcher, Gunter; Jones, Garry D.; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.Michael; Tainer, John A.. (2000) Uracil-DNA glycosylase-DNA substrate and product structures:Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, Hilde; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters
Vitenskapelig artikkel
Nilsen, Hilde; Rosewell, I.; Robins, P.; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Krokan, Hans Einar; Lindahl, T.; Barnes, D.E.. (2000) ) Ung-deficient mice reveal a primary role of the uracil-DNA glycosylase enzyme during DNA replication. Molecular Cell
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, H.; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair in mammalian cells. FEBS Letters
Vitenskapelig artikkel
Otterlei, Marit; Kavli, B; Standal, R; Skjelbred, Camilla; Bharati, S; Krokan, Hans Einar. (2000) Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO Journal
Vitenskapelig artikkel
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Parikh, S; Walcher, G; Jones, G.D; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.M; Tainer, J.A. (2000) Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Vitenskapelig artikkel
Smeland, Erlend; Prydz, Hans; Ørstadvik, Karen Helene; Frøland, Stig; Aamdal, Steinar; Myklebost, Ola; Apold, Jaran; Børresen-Dale, Anne-Lise; Seeberg, Erling; Hovig, Eivind. (2000) Genterapi Status og fremtidige muligheter innen klinisk medisin. Lobo Grafisk AS
Faglig monografi
Otterlei, Marit; Kavli, Bodil; Standal, Rune; Skjelbred, Camilla; Bharati, Sangeeta; Krokan, Hans Einar. (2000) Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO Journal
Vitenskapelig artikkel
Nilsen, Hilde; Rosewell, Ian; Robins, Peter; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Daly, Graham; Krokan, Hans Einar; Lindahl, Tomas; Barnes, Deborah E.. (2000) URACIL-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication. Molecular Cell
Vitenskapelig artikkel
Smeland, Erlend B; Prydz, Hans Peter B; Ørstavik, Karen Helene; Frøland, Stig Sophus; Aamdal, Steinar; Myklebost, Ola; Apold, J; Børresen-Dale, Anne-Lise; Seeberg, Erling Christen; Hovig, Eivind. (2000) Genterapi. Status og fremtidige muligheter innen klinisk medisin.
Vitenskapelig kapittel

1999

Waldum, Helge; Sandvik, Arne Kristian; Angelsen, Anders; Krokan, Hans Einar; Falkmer, Sture Emil. (1999) Letter to the Editor: Re. Editorial entitled "The origin of gut and pancreatic neuroendocrine (APUD) cells - the last word?". Journal of Pathology
Vitenskapelig artikkel
Schønberg, Svanhild; Krokan, Hans Einar. (1999) Fisk tar knekken på kreftceller. Aftenposten (morgenutg. : trykt utg.)
Populærvitenskapelig artikkel
Krokan, Hans Einar; Schønberg, Svanhild; Rudra, Parveen Kumar. (1999) Dreper kreft : sporet etter de krefthemmende mekanismene i Omega-3 (n-3fettsyrer) er blitt sterkere. Teknisk Ukeblad
Populærvitenskapelig artikkel
Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bhariti, Sangeeta; Steinsbekk, Kristin; Nilsen, Hilde; Skjelbred, Camilla; Kavli, Bodil; Standal, Rune; Slupphaug, Geir. (1999) Human uracil-DNA glycosylase. NATO Advances Study Institute series. Series A, Life sciences
Vitenskapelig artikkel
Rudra, Parveen K.; Krokan, Hans Einar. (1999) Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells. Anticancer Research
Vitenskapelig artikkel
Otterlei, Marit; Warbrick, Emma; Nagelhus, Toril; Haug, Terje; Slupphaug, Geir; Akbari, Mansour; Aas, Per Arne; Steinsbekk, Kristin; Bakke, Oddmund; Krokan, Hans Einar. (1999) Post-replicative base excision repair in replication foci. EMBO Journal
Vitenskapelig artikkel
Waldum, Helge; Sandvik, AK; Angelsen, Anders; Krokan, Hans Einar; Falkmer, S. (1999) Re. Editorial entitled "The origin of gut and pancreatic neuroendocrine (APUD) cells-the last word?". Journal of Pathology
Vitenskapelig artikkel
Waldum, Helge; Sandvik, AK; Angelsen, Anders; Krokan, Hans Einar. (1999) The origin of gut and pancreatic neuroendocrine cells - the last word?. Journal of Pathology
Vitenskapelig artikkel
Krokan, Hans Einar. (1999) Kapittel 16: Vann og elektrolytter.
Vitenskapelig kapittel

1998

Krokan, Hans Einar; Parikh, S.S.; Slupphaug, Geir; Bharati, S; Trainer, J.A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO Journal
Vitenskapelig artikkel
Haug, T.; Skorpen, Frank; Aas, P.A.; Malm, V; Skjelbred, Camilla; Krokan, Hans Einar. (1998) Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Nøding, R.; Schønberg, S.A.; Krokan, Hans Einar; Bjerve, K.S.. (1998) Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media. Lipids
Vitenskapelig artikkel
Bharati, S.; Krokan, Hans Einar; Kristiansen, L; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bharati, S; Steinsbekk, Kristin; Nilsen, Hilde; Hernes, T Nagelhus-; Haug, T; Aas, Per A; Akbari, M. (1998) Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis. Plenum Press
Faglig monografi
Parikh, S. Sudip; Mol, Clifford D.; Slupphaug, Geir; Bharati, Sangeta; Krokan, Hans Einar; Yainer, John A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Otterlei, Marit; Haug, T.; Nagelhus, T.A; Slupphaug, Geir; Lindmo, T.; Krokan, Hans Einar. (1998) Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localization signal and a strong classical mitochondrial localizations signal, respectively. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (1998) DNA-reparasjonsenzymer og deres gener. Tidsskrift for Den norske legeforening (Tidsskriftet)
Vitenskapelig artikkel
Skorpen, Frank; Skjelbred, Camilla; Aas, P.A.; Alm, B.; Schønberg, S.A.; Krokan, Hans Einar. (1998) Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus. Mutation Research (DNA Repair)
Vitenskapelig artikkel
Skorpen, Frank; Alm, B.; Skjelbred, Camilla; Aas, P.A.; Krokan, Hans Einar. (1998) Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells. Chemico-Biological Interactions
Vitenskapelig artikkel

1997

Krokan, Hans Einar; Standal, Rune; Bharati, Sangeeta; Otterlei, Marit; Haug, Terje; Slupphaug, Geir; Skorpen, Frank. (1997) Uracil in DNA and the family of concerved uracil DNA glycosylases.
Vitenskapelig kapittel
Schønberg, Svanhild A.; Rudra, Parveen K.; Nøding, Randi; Skorpen, Frank; Bjerve, Kristian S; Krokan, Hans Einar. (1997) Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids. Carcinogenesis
Vitenskapelig artikkel
Krokan, Hans Einar; Standal, Rune; Slupphaug, Geir. (1997) DNA glycosylase in the base excision repair of DNA. Biochemical Journal
Vitenskapelig artikkel
Schønberg, S.M.; Rudra, P.K.; Nøding, R.; Bjerve, K.S; Krokan, Hans Einar. (1997) Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids. Carcinogenesis
Vitenskapelig artikkel
Nilsen, H.; Otterlei, Marit; Haug, T.; Solum, K.; Nagelhus, T.A; Skorpen, Frank; Krokan, Hans Einar. (1997) Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Nagelhus, T.; Haug, T.; Singh, K.K.; Keshav, K.F.; Skorpen, Frank; Bharati, S.; Otterlei, Marit; Lindmo, T.; Benichou, S.; Benarous, R.. (1997) A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit o replication protein A. Journal of Biological Chemistry
Vitenskapelig artikkel

1996

Dizdaroglu, Miral; Karakaya, Asuman; Jaruga, Pawel; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Lund, Henning; Eftedal, Ingrid; Haug, Terje; Krokan, Hans Einar. (1996) Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16. Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
Slupphaug, Geir; Mol, Clifford D.; Kavli, Bodil; Arvai, Andrew S.; Krokan, Hans Einar; Tainer, John A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature
Vitenskapelig artikkel
Haug, Terje; Skorpen, Frank; Kvaløy, Kirsti; Eftedal, Ingrid; Lund, Henning; Krokan, Hans Einar. (1996) Human uracil-DNA glycosylase gene : sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Genomics
Vitenskapelig artikkel
Kavli, Bodil; Slupphaug, Geir; Mol, Clifford D.; Arvai, Andrew S.; Petersen, Steffen B.; Tainer, John A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Lehmann, A.R.; Bridges, B.A.; Hanawalt, P.C.; Johnson, R.T.; Kanaar, R.; Krokan, Hans E.; Seeberg, Erling Christen. (1996) Workshop on processing of DNA damage. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Vitenskapelig artikkel
Nagelhus, T.; Slupphaug, Geir; Krokan, Hans Einar; Lindmo, T.. (1996) Fading correction for fluorescence quantitation in confocal microscopy. Cytometry
Vitenskapelig artikkel
Kavli, B.; Slupphaug, Geir; Mol, C.D.; Arvai, A.S.; Petersen, S.B.; Tainer, J.A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Lund, H.; Eftedal, I.; Haug, T.; Krokan, Hans Einar. (1996) Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
Haug, T.; Skorpen, Frank; Lund, H.; Eftedal, I.; Kvaløy, K.; Krokan, Hans Einar. (1996) Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Genomics, Society and Policy
Vitenskapelig artikkel
Slupphaug, Geir; Kavli, B.; Mol, C.D.; Arvai, A.; Krokan, Hans Einar; Tainer, J.A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature
Vitenskapelig artikkel
Dizdaroglu, M.; Karakaya, A.; Jaruga, P.; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR)
Vitenskapelig artikkel

1995

Nilsen, Hilde; Yazdankhah, Siamak Pour; Eftedal, Ingrid; Krokan, Hans Einar. (1995) Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots. FEBS Letters
Vitenskapelig artikkel
Slupphaug, Geir; Eftedal, Ingrid; Kavli, Bodil; Bharati, Sangeeta; Helle, Nils M; Haug, Terje; Levine, David William; Krokan, Hans Einar. (1995) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry
Vitenskapelig artikkel

1993

Eftedal, Ingrid; Guddal, Per Henrik; Slupphaug, Geir; Volden, Gunnar; Krokan, Hans Einar. (1993) Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Krokan, Hans Einar; Bjerve, Kristian S; Mørk, E.. (1993) The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro. Biochimica et Biophysica Acta
Vitenskapelig artikkel
Slupphaug, G.; Markussen, F.-H.; Olsen, Lisbeth Charlotte; Aasland, Rein; Aarsæther, Niels; Bakke, O.; Krokan, H. E.; Helland, Dag Emil. (1993) Human Uracil-DNA glycosylase is shared by the nucleus and the mitochondria. Nucleic Acid Res
Vitenskapelig artikkel
Slupphaug, Geir; Alseth, Ingrun; Eftedal, Ingrid; Volden, Gunnar; Krokan, Hans Einar. (1993) Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification. Analytical Biochemistry
Vitenskapelig artikkel
Krokan, Hans Einar; Valla, Svein; Bones, Atle. (1993) Markørgener - sikkerhet for helse og miljø. Direktoratet for naturforvaltning
Faglig monografi
Krokan, Hans Einar. (1993) Omega-3 fatty acids : metabolism and biological effects. Birkhæuser Verlag
Faglig monografi

1992

Krokan, Hans Einar. (1992) Expression of O(6)-methylguanine - DNA methyltransferase and uracilDNA lycosylase in human placentae from smokers and non-smokers. Carcinogenesis
Vitenskapelig artikkel
Olsen, Lisbeth Charlotte; Aasland, Rein; Krokan, H. E.; Helland, Dag Emil. (1992) Human uracil DNA glycosylase cDNA complements E.coli ung mutants. Nucleic Acid Res
Vitenskapelig artikkel

1991

Slupphaug, G.; Olsen, Lisbeth Charlotte; Helland, Dag Emil; Aasland, Rein; Krokan, H. E.. (1991) Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil- DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel

1990

Aasland, Rein; Olsen, Lisbeth Charlotte; Spurr, N. K.; Krokan, H. E.; Helland, Dag Emil. (1990) Chromosomal assignment of Human Uracil-DNA Glycosylase to Chromosome 12. Genomics
Vitenskapelig artikkel

1978

Wist, Erik; Undhjem, O; Krokan, Hans E.. (1978) Accumulation of small fragments of DNA in isolated HeLa cell nuclei due to transient incorporation of dUMP. Biochimica et Biophysica Acta
Vitenskapelig artikkel
Wist, Erik; Krokan, Hans E.. (1978) Preservation by glycerol of DNA synthetic capacity of isolated HeLa cell nuclei during long term storage at low temperature. Experimental Cell Research
Vitenskapelig artikkel

1977

Krokan, Hans E.; Wist, Erik; Prydz, Hans Peter B. (1977) Effect of cytosol on DNA synthesis in isolated nuclei. Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
Krokan, Hans E.; Wist, Erik; Prydz, Hans Peter B. (1977) DNA replication intermediates in whole HeLa cells and isolated nuclei. Biochimica et Biophysica Acta
Vitenskapelig artikkel

1976

Wist, Erik; Krokan, Hans E.; Prydz, Hans Peter B. (1976) Effect of 1-beta-D-arabionsyl-cytosine-triphosphate on DNA synthesis in HeLa cell nuclei. Biochemistry
Vitenskapelig artikkel

Tidsskriftspublikasjoner

Holthe, Monica; Klepstad, Pål; Zahlsen, Kolbjørn; Borchgrevink, Petter Chr.; Hagen, Lars; Dale, Ola; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2002) Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1a1*28 polymorphisms in cancer patients on chronic morphine therapy. European Journal of Clinical Pharmacology
Vitenskapelig artikkel
Waldum, Helge; Sandvik, Arne Kristian; Angelsen, Anders; Krokan, Hans Einar; Falkmer, Sture Emil. (1999) Letter to the Editor: Re. Editorial entitled "The origin of gut and pancreatic neuroendocrine (APUD) cells - the last word?". Journal of Pathology
Vitenskapelig artikkel
Hu, Yi; Ericsson, Ida; Torseth, Kathrin; Methot, Stephen; Sundheim, Ottar; Liabakk, Nina-Beate; Slupphaug, Geir; Noia, Javier Di; Krokan, Hans Einar; Kavli, Bodil Merete. (2013) A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching. Journal of Molecular Biology (JMB)
Vitenskapelig artikkel
Akbari, Mansour; Visnes, Torkild; Krokan, Hans Einar; Otterlei, Marit. (2008) Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis. DNA Repair
Vitenskapelig artikkel
Andersen, Sonja Benedikte; Krokan, Hans Einar; Baar, Cecilie Christensen; Rakvag, Trude Teoline; Laugsand, Eivor Alette; Kvam, Tor-Morten; Torill, Fladvad; Skorpen, Frank. (2008) Identification of an alternative, putative promoter and new alternatively spliced transcripts from the human µ opioid receptor gene, OPRM1. Palliative Medicine
Konferanseabstract
Akbari, Mansour; Hansen, Marianne Dore; Halgunset, Jostein; Skorpen, Frank; Krokan, Hans Einar. (2005) Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner. Journal of Molecular Diagnostics
Vitenskapelig artikkel
Krokan, Hans Einar; Otterlei, Marit; Nilsen, Hilde; Kavli, Bodil; Skorpen, Frank; Andersen, Sonja; Skjelbred, Camilla Furu; Akbari, Mansour; Aas, Per Arne; Slupphaug, Geir. (2001) Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene. Progress in Nucleic Acid Research and Molecular Biology
Vitenskapelig artikkel
Akbari, Mansour; Diaz, Javier Pena; Andersen, Sonja Benedikte; Liabakk, Nina-Beate; Otterlei, Marit; Krokan, Hans Einar. (2009) Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity. DNA Repair
Vitenskapelig artikkel
Wist, Erik; Undhjem, O; Krokan, Hans E.. (1978) Accumulation of small fragments of DNA in isolated HeLa cell nuclei due to transient incorporation of dUMP. Biochimica et Biophysica Acta
Vitenskapelig artikkel
Wist, Erik; Krokan, Hans E.. (1978) Preservation by glycerol of DNA synthetic capacity of isolated HeLa cell nuclei during long term storage at low temperature. Experimental Cell Research
Vitenskapelig artikkel
Robertson, Adam Brian; Dahl, John Arne; Vågbø, Cathrine Broberg; Tripathi, P; Krokan, Hans Einar; Klungland, Arne. (2011) A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Research (NAR)
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Krokan, Hans Einar; Bjørås, Magnar. (2013) Base Excision Repair. Cold Spring Harbor Perspectives in Biology
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Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra; Gustafsson, Robert; Wiita, Elisée; Borhade, Sanjay; Green, Alanna C.; Vallin, Karl S. A.; Sarno, Antonio. (2022) Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nature Cancer
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Kazma, R; Babron, MC; Gaborieau, Valerie; Génin, E; Brennan, P; Hung, Rayjean J.; McLaughlin, Jon; Krokan, Hans Einar; Gabrielsen, Maiken Elvestad; Skorpen, Frank. (2012) Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. Carcinogenesis
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Sletta, Håvard; Klinkenberg, Geir; Winnberg, Asgeir; Kvitvang, Hans Fredrik Nyvold; Nilsen, Marianne Bakke; Krokan, Hans Einar; Otterlei, Marit; Bruheim, Per. (2011) A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants. Journal of Microbiological Methods
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Diaz, Javier Pena; Hegre, Siv Anita; Anderssen, Endre; Aas, Per Arne; Mjelle, Robin; Gilfillan, Gregor Duncan; Lyle, Robert; Drabløs, Finn; Krokan, Hans Einar; Sætrom, Pål. (2013) Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication. Nucleic Acids Research (NAR)
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Krokan, Hans E.; Wist, Erik; Prydz, Hans Peter B. (1977) Effect of cytosol on DNA synthesis in isolated nuclei. Biochemical and Biophysical Research Communications - BBRC
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Wist, Erik; Krokan, Hans E.; Prydz, Hans Peter B. (1976) Effect of 1-beta-D-arabionsyl-cytosine-triphosphate on DNA synthesis in HeLa cell nuclei. Biochemistry
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Krokan, Hans E.; Wist, Erik; Prydz, Hans Peter B. (1977) DNA replication intermediates in whole HeLa cells and isolated nuclei. Biochimica et Biophysica Acta
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Krokan, Hans Einar. (2001) Biologiens århundre er nå. Fondsfinans Farmasi - Bioteknologi, Årsrapport 2000
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Nilsen, Hilde; Yazdankhah, Siamak Pour; Eftedal, Ingrid; Krokan, Hans Einar. (1995) Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots. FEBS Letters
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Wang, Yufei; McKay, JD; Rafnar, T; Wang, Z; Timofeeva, MN; Broderick, P; Zong, X; Laplana, M; Wei, Y; Han, Y. (2014) Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nature Genetics
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Eftedal, Ingrid; Guddal, Per Henrik; Slupphaug, Geir; Volden, Gunnar; Krokan, Hans Einar. (1993) Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase. Nucleic Acids Research (NAR)
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Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne; Grini, Paul Eivind; Falnes, Pål. (2012) The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research (NAR)
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Hegre, Siv Anita; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Otterlei, Marit; Krokan, Hans Einar. (2013) Multiple microRNAs may regulate DNA repair enzyme uracil‐DNA glycosylase. DNA Repair
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Krokan, Hans Einar; Bjerve, Kristian S; Mørk, E.. (1993) The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro. Biochimica et Biophysica Acta
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Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Krokan, Hans Einar. (2006) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience
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Johnson, Matthew P; Brennecke, Shaun P.; Iversen, Ann-Charlotte; East, Christine; Olsen, Guro Dalheim; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Abraham, Lawrence J. (2012) Genome-wide association scans identify novel maternal susceptibility loci for preeclampsia. Pregnancy Hypertension
Konferanseabstract
Krokan, Hans Einar; Slupphaug, Geir. (2006) Preface. DNA Repair
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Schønberg, Svanhild; Krokan, Hans Einar. (1999) Fisk tar knekken på kreftceller. Aftenposten (morgenutg. : trykt utg.)
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Akbari, Mansour; Otterlei, Marit; Pena-Diaz, J; Krokan, Hans Einar. (2007) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience
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Krokan, Hans Einar; Schønberg, Svanhild; Rudra, Parveen Kumar. (1999) Dreper kreft : sporet etter de krefthemmende mekanismene i Omega-3 (n-3fettsyrer) er blitt sterkere. Teknisk Ukeblad
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Holthe, M.; Rakvåg, Trude Teoline; Klepstad, Pål; Idle, Jefrrey R.; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2003) Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. The Pharmacogenomics Journal
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Landi, MT; Chatterjee, N; Yu, K; Goldin, LR; Goldstein, AM; Rotunno, M; Mirabello, L; Jacobs, K; Jacobs, K; Wheeler, W. (2009) A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma. American Journal of Human Genetics
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Feyzi, Emadoldin; Aas, Per Arne; Sundheim, Ottar; Westbye, Marianne; Vågbø, Cathrine Broberg; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) RNA Base Damage and Repair. Current Pharmaceutical Biotechnology
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Xue, JH; Xu, GF; Gu, TP; Chen, GD; Han, BB; Xu, ZM; Bjørås, Magnar; Krokan, Hans Einar; Xu, GL; Du, Yr. (2016) Uracil-DNA glycosylase UNG promotes tet-mediated DNA demethylation. Journal of Biological Chemistry
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Hjelde, Astrid; Gederaas, Odrun Arna; Krokan, Hans Einar; Brubakk, Alf O. (2005) Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines. Medical Science Monitor
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Andersen, S; Heine, T; Sneve, Ragnhild; Konig, I; Krokan, HE; Epe, B; Nilsen, Hilde. (2005) Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis
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Boeckemeier, L; Kraehenbuehl, R; Keszthelyi, A; Gasasira, MU; Vernon, EG; Beardmore, R; Vågbø, Cathrine Broberg; Chaplin, D; Gollins, S; Krokan, Hans Einar. (2020) Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication. Science Advances
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Visnes, Torkild; Armando, Cazares-Körner; Wenjing, Hao; Wallner, Olov; Masuyer, Geoffrey; Loseva, Olga; Mortusewicz, Oliver; Wiita, Elisee; Sarno, Antonio; Manoilov, Aleksandr. (2018) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science
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Monsen, Vivi A Talstad; Sundheim, Ottar; Aas, Per Arne; Westbye, Marianne Pedersen; Sousa, Mirta; Slupphaug, Geir; Krokan, Hans Einar. (2010) Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3. Nucleic Acids Research (NAR)
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Andersen, S; Ericsson, M; DAI, H; Peña-Diaz, J; Slupphaug, G; Nilsen, Hilde; Aarset, H; Krokan, HE. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair
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Sundheim, Ottar; Talstad, Vivi A; Vågbø, Cathrine Broberg; Slupphaug, Geir; Krokan, Hans Einar. (2008) AlkB demethylases flip out in different ways. DNA Repair
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Westbye, Marianne; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi A; Kavli, Bodil Merete; Hagen, Lars; Sundheim, Ottar; Akbari, Mansour; Liabakk, Nina-Beate. (2008) Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Journal of Biological Chemistry
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Visnes, Torkild; Akbari, Mansour; Hagen, Lars; Slupphaug, Geir; Krokan, Hans Einar. (2008) The rate of base excision repair of uracil is controlled by the initiating glycosylase. DNA Repair
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Aas, Per Arne; Diaz, Javier Pena; Liabakk, Nina-Beate; Krokan, Hans Einar; Skorpen, Frank. (2009) Overexpression of transcription factor AP-2 stimulates the P-A promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression. DNA Repair
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Sousa, Mirta; Krokan, Hans Einar; Slupphaug, Geir. (2007) DNA-uracil and human pathology. Molecular Aspects of Medicine
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Dusseau, C.; Murray, GI; Keenan, RA; OKelly, T.; Krokan, Hans Einar; McLeod, HL. (2001) Analysis of uracil DNA glycosylase in human colorectal cancer. International Journal of Oncology
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Schønberg, Svanhild A.; Rudra, Parveen K.; Nøding, Randi; Skorpen, Frank; Bjerve, Kristian S; Krokan, Hans Einar. (1997) Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids. Carcinogenesis
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Krokan, Hans Einar; Standal, Rune; Slupphaug, Geir. (1997) DNA glycosylase in the base excision repair of DNA. Biochemical Journal
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Kvaløy, Kirsti; Nilsen, H.; Steinsbekk, Kristin; Nedal, Aina; Monterotti, Bruno; Akbari, Mansour; Krokan, Hans Einar. (2001) Sequence variation in the human uracil-DNA glycosylase (UNG) gene. Mutation Research (DNA Repair)
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Krokan, Hans Einar; Prydz, H.. (2001) Genoverføring - administrasjonsmåter, fordeler, mulige ulemper og farer. Tidsskrift for Den norske legeforening (Tidsskriftet)
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Olinski, Ryszard; Slupphaug, Geir; Foksinski, Marek; Krokan, Hans Einar. (2021) Genomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignancies. International Journal of Molecular Sciences
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Mjelle, Robin; Hegre, Siv Anita; Aas, Per Arne; Slupphaug, Geir; Drabløs, Finn; Sætrom, Pål; Krokan, Hans Einar. (2015) Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair
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Slupphaug, Geir; Eftedal, Ingrid; Kavli, Bodil; Bharati, Sangeeta; Helle, Nils M; Haug, Terje; Levine, David William; Krokan, Hans Einar. (1995) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry
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Klepstad, Pål; Rakvag, TT; Kaasa, Stein; Holthe, Monica; Dale, Ola; Borchgrevink, Petter Chr.; Baar, Cecilie Christensen; Vikan, T; Krokan, Hans Einar; Skorpen, Frank. (2004) The 118 A>G polymorphism in the human mu-opioid receptor gene may increase morphins requirements in patients with pain caused by malignant disease. Acta Anaesthesiologica Scandinavica
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Aasland, Rein; Olsen, Lisbeth Charlotte; Spurr, N. K.; Krokan, H. E.; Helland, Dag Emil. (1990) Chromosomal assignment of Human Uracil-DNA Glycosylase to Chromosome 12. Genomics
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Slupphaug, G.; Markussen, F.-H.; Olsen, Lisbeth Charlotte; Aasland, Rein; Aarsæther, Niels; Bakke, O.; Krokan, H. E.; Helland, Dag Emil. (1993) Human Uracil-DNA glycosylase is shared by the nucleus and the mitochondria. Nucleic Acid Res
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Songe-Møller, Lene; Van den Born, Erwin; Leihne, V; Vågbø, Cathrine Broberg; Kristoffersen, T; Krokan, Hans Einar; Kirpekar, F; Falnes, PO; Klungland, A. (2010) Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding. Molecular and Cellular Biology
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Rudra, Parveen; Krokan, Hans Einar. (2001) Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid. Anticancer Research
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Krokan, Hans Einar; Prydz, H.. (2001) Genoverføring - administrasjonsmåter, fordeler, mulige ulemper og farer. Tidsskrift for Den norske legeforening (Tidsskriftet)
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Slagsvold, Jens Erik; Pettersen, Caroline Hild; Follestad, Turid; Krokan, Hans Einar; Schønberg, Svanhild Margrethe Arentz. (2009) The Antiproliferative Effect of EPA in HL60 Cells is Mediated by Alterations in Calcium Homeostasis. Lipids
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Baglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda; Zub, Kamila; Krokan, Hans Einar; Gederaas, Odrun Arna. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Photochemical and Photobiological Sciences
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Akbari, Mansour; Krokan, Hans Einar. (2012) Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-Implications for comparative studies. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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Visnes, Torkild; Benitez-Buelga, Carlos; Cázares-Körner, Armando; Sanjiv, Kumar; Hanna, Bishoy M F; Mortusewicz, Oliver; Rajagopal, Varshni; Albers, Julian J.; Hagey, Daniel W.; Bekkhus, Tove. (2020) Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Research (NAR)
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Hagen, Lars; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2006) Genomic uracil and human disease. Experimental Cell Research
Vitenskapelig oversiktsartikkel
Krokan, Hans Einar. (2008) NBS 40 år. NBS-nytt
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Kvam, TM; Baar, Cecilie Christensen; Raakvag, Trude Teoline; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2004) Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing. Journal of Molecular Medicine
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Krokan, Hans Einar. (1992) Expression of O(6)-methylguanine - DNA methyltransferase and uracilDNA lycosylase in human placentae from smokers and non-smokers. Carcinogenesis
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Krokan, Hans Einar. (2012) A life in DNA repair-And beyond. DNA Repair
Leder
Akbari, M; Skjelbred, C; Folling, I; Sagen, Jørn V.; Krokan, HE. (2004) A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA (Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss. Scandinavian Journal of Clinical and Laboratory Investigation
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Kavli, Bodil Merete; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2007) Uracil in DNA - General mutagen, but normal intermediate in acquired immunity. DNA Repair
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Krokan, Hans Einar; Sætrom, Pål; Aas, Per Arne; Pettersen, Henrik P Sahlin; Kavli, Bodil Merete; Slupphaug, Geir. (2014) Error-free versus mutagenic processing of genomic uracil-Relevance to cancer. DNA Repair
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McKay, JD; Mckay, JD; Hung, RJ; Gaborieau, V; Boffetta, Paolo; Chabrier, Amelie; Byrnes, GB; Zaridze, D; Mukeria, A; Szeszenia-Dabrowska, N. (2008) Lung cancer susceptibility locus at 5p15.33. Nature Genetics
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Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA- from molecular biology to phenotype. DNA Repair
Konferanseabstract
Slupphaug, G.; Olsen, Lisbeth Charlotte; Helland, Dag Emil; Aasland, Rein; Krokan, H. E.. (1991) Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil- DNA glycosylase. Nucleic Acids Research (NAR)
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Krokan, Hans Einar; Kavli, Bodil Merete; Akbari, Mansour; Visnes, Torkild; Pettersen, Henrik P Sahlin; Sundheim, Ottar; Hagen, Lars; Otterlei, Marit; Gilljam, Karin Margaretha; Slupphaug, Geir. (2007) Repair og uracil in DNA by UNG2 and SMUG1 - an update. DNA Repair
Konferanseabstract
Sarno, Antonio; Lundbæk, Marie Benner; Liabakk, Nina-Beate; Aas, Per Arne; Mjelle, Robin; Hagen, Lars; Sousa, Mirta; Krokan, Hans Einar; Kavli, Bodil Merete. (2019) Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil. Nucleic Acids Research (NAR)
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Leihne, VIbeke; Kirpekar, F; Vågbø, Cathrine Broberg; Van den Born, Erwin; Krokan, Hans Einar; Grini, Paul Eivind; Meza, Trine Johansen; Falnes, Pål. (2011) Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Hung, RJ; Mckay, JD; Gaborieau, V; Boffetta, P; Hashibe, M; Zaridze, D; Mukeria, A; Szeszenia-Dabrowska, N; Lissowska, J; Rudnai, P. (2008) A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature
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Helander, Linda; Sharma, Animesh; Krokan, Hans Einar; Plaetzer, Kristjan; Krammer, Barbara; Tortik, Nicole; Gederaas, Odrun Arna; Slupphaug, Geir; Hagen, Lars. (2016) Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins. Molecular Biosystems
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Pettersen, Henrik P Sahlin; Sundheim, Ottar; Gilljam, Karin Margaretha; Slupphaug, Geir; Krokan, Hans Einar; Kavli, Bodil Merete. (2007) Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms. Nucleic Acids Research (NAR)
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Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bhariti, Sangeeta; Steinsbekk, Kristin; Nilsen, Hilde; Skjelbred, Camilla; Kavli, Bodil; Standal, Rune; Slupphaug, Geir. (1999) Human uracil-DNA glycosylase. NATO Advances Study Institute series. Series A, Life sciences
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Slagsvold, Jens Erik; Pettersen, Caroline Hild; Størvold, Gro Leite; Follestad, Turid; Krokan, Hans Einar; Schønberg, Svanhild Margrethe Arentz. (2010) DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells. Nutrition and Cancer
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Ringvoll, Jeanette; Ringvoll, Jeanette; Nordstrand, Line M.; Vågbø, Cathrine Broberg; Vagbo, CB; Talstad, Vivi; Reite, Karen; Aas, Per Arne; Lauritzen, Knut H.; Liabakk, Nina-Beate. (2006) Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO Journal
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Wang, Yufei; McKay, James D.; Rafnar, Thorunn; Wang, Zhaoming; Timofeeva, Maria N.; Broderick, Peter; Zong, Xuchen; Laplana, Marina; Wei, Yongyue; Han, Younghun. (2017) Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer (Nature Genetics (2014) 46 (736-741)). Nature Genetics
Korrigendum
Dizdaroglu, Miral; Karakaya, Asuman; Jaruga, Pawel; Slupphaug, Geir; Krokan, Hans Einar. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Lund, Henning; Eftedal, Ingrid; Haug, Terje; Krokan, Hans Einar. (1996) Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16. Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
Slupphaug, Geir; Mol, Clifford D.; Kavli, Bodil; Arvai, Andrew S.; Krokan, Hans Einar; Tainer, John A.. (1996) A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature
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Heath, SC; Gut, IG; Brennan, P; Mckay, JD; Bencko, V; Fabianova, E; Foretova, L; Georges, M; Janout, V; Kabesch, M. (2008) Investigation of the fine structure of European populations with applications to disease association studies. European Journal of Human Genetics
Vitenskapelig artikkel
Akbari, Mansour; Garten, Karin Solvang-; Hanssen-Bauer, Audun; Lieske, Nora V.; Pettersen, Henrik P Sahlin; Pettersen, Grete Klippenvåg; Wilson, DM; Krokan, Hans Einar; Otterlei, Marit. (2010) Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair
Vitenskapelig artikkel
Haug, Terje; Skorpen, Frank; Kvaløy, Kirsti; Eftedal, Ingrid; Lund, Henning; Krokan, Hans Einar. (1996) Human uracil-DNA glycosylase gene : sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. Genomics
Vitenskapelig artikkel
Kavli, Bodil; Slupphaug, Geir; Mol, Clifford D.; Arvai, Andrew S.; Petersen, Steffen B.; Tainer, John A.; Krokan, Hans Einar. (1996) Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. EMBO Journal
Vitenskapelig artikkel
Olsen, Lisbeth Charlotte; Aasland, Rein; Krokan, H. E.; Helland, Dag Emil. (1992) Human uracil DNA glycosylase cDNA complements E.coli ung mutants. Nucleic Acid Res
Vitenskapelig artikkel
Krokan, Hans Einar; Parikh, S.S.; Slupphaug, Geir; Bharati, S; Trainer, J.A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO Journal
Vitenskapelig artikkel
Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine UNG gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Parikh, Sudip S.; Walcher, Gunter; Jones, Garry D.; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.Michael; Tainer, John A.. (2000) Uracil-DNA glycosylase-DNA substrate and product structures:Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
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Robles, Ana I.; Olsen, Karina Standahl; Tsui, Dana W.T.; Georgoulias, Vassilis; Creaney, Jenette; Dobra, Katalin; Vyberg, Mogens; Minato, Nagahiro; Anders, Robert A.; Børresen-Dale, Anne-Lise. (2016) Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway. Journal of Translational Medicine
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Rasmussen, Erik; Vågbø, Cathrine Broberg; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne; Amdam, Gro Vang; Dahl, John Arne. (2016) DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates. Biochemistry and Biophysics Reports
Vitenskapelig artikkel
Krokan, Hans Einar; Nilsen, Hilde; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters
Vitenskapelig artikkel
Haug, T.; Skorpen, Frank; Aas, P.A.; Malm, V; Skjelbred, Camilla; Krokan, Hans Einar. (1998) Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase. Nucleic Acids Research (NAR)
Vitenskapelig artikkel
Nøding, R.; Schønberg, S.A.; Krokan, Hans Einar; Bjerve, K.S.. (1998) Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media. Lipids
Vitenskapelig artikkel
Bharati, S.; Krokan, Hans Einar; Kristiansen, L; Otterlei, Marit; Slupphaug, Geir. (1998) Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites. Nucleic Acids Research (NAR)
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Akbari, M; Skjelbred, C; Følling, Ivar; Sagen, J; Krokan, H E. (2004) A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA Leu (UUR)) applied to a Norwegian family with diabetes mellitus and hearing loss. Scandinavian Journal of Clinical and Laboratory Investigation
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Pettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Research (NAR)
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Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fedorcsak, Peter; Huang, Chun-Min; Li, Charles J.; Vågbø, Cathrine Broberg; Shi, Yue; Wang, Wen-Ling; Song, Shu-Hui. (2013) ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Molecular Cell
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Holthe, Monica; Råkvåg, Trude Teoline; Klepstad, Pål; Idle, Jefrrey R.; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2003) Identification of 10 novel single nucleotide polymorphisms and analysis of their relevance to morphine glucuronidation. The Pharmacogenomics Journal
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Klepstad, Pål; Rakvag, Trude Teoline; Kaasa, Stein; Holthe, Monica; Dale, Ola; Borchgrevink, Petter Chr.; Baar, Cecilie Christensen; Krokan, Hans Einar; Skorpen, Frank. (2004) The 118 A>G polymorphism in the human µ-opioidreceptor gene may increase morphine requrements in patients with pain caused by malignant disease. Acta Anaesthesiologica Scandinavica
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Nilsen, Hilde; Rosewell, I.; Robins, P.; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Krokan, Hans Einar; Lindahl, T.; Barnes, D.E.. (2000) ) Ung-deficient mice reveal a primary role of the uracil-DNA glycosylase enzyme during DNA replication. Molecular Cell
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Krokan, Hans Einar; Nilsen, H.; Skorpen, Frank; Otterlei, Marit; Slupphaug, Geir. (2000) Base excision repair in mammalian cells. FEBS Letters
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Slagsvold, Jens Erik; Pettersen, Caroline Hild; Follestad, Turid; Krokan, Hans Einar; Schønberg, Svanhild Margrethe Arentz. (2008) The antiproliferative effect of EPA in HL60 cells is mediated by alterations in calcium homeostasis. Lipids
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Slupphaug, Geir; Alseth, Ingrun; Eftedal, Ingrid; Volden, Gunnar; Krokan, Hans Einar. (1993) Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplification. Analytical Biochemistry
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Akbari, Mansour; Krokan, Hans Einar. (2008) Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging. Mechanisms of Ageing and Development
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Krokan, Hans Einar. (2004) Molecular and functional interactions in macromolecular repair. European Journal of Biochemistry (EJB)
Konferanseabstract
Otterlei, Marit; Kavli, B; Standal, R; Skjelbred, Camilla; Bharati, S; Krokan, Hans Einar. (2000) Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO Journal
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Nilsen, Hilde; Steinsbekk, Kristin; Otterlei, Marit; Slupphaug, Geir; Aas, Per Arne; Krokan, Hans Einar. (2000) Analysis of uracil-DNA glycosylases from the murine Ung-gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nucleic Acids Research (NAR)
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Parikh, S; Walcher, G; Jones, G.D; Slupphaug, Geir; Krokan, Hans Einar; Blackburn, G.M; Tainer, J.A. (2000) Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
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Sundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Mittelstedt, L.Mirta; Talstad, Vivi; Aas, Per Arne; Drabløs, Finn; Krokan, Hans Einar; Tainer, John A.; Slupphaug, Geir. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO Journal
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Diaz, Javier Pena; Akbari, Mansour; Sundheim, Ottar; Farez-Vidal, ME; Andersen, S; Sneve, R; Gonzalez-Pacanowska, D; Krokan, Hans Einar; Slupphaug, Geir. (2004) Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair. Journal of Molecular Biology (JMB)
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Akbari, Mansour; Skjelbred, C; Folling, I; Sagen, J; Krokan, Hans Einar. (2004) A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss. Scandinavian Journal of Clinical and Laboratory Investigation
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Akbari, Mansour; Otterlei, Marit; Diaz, Javier Pena; Aas, Per Arne; Kavli, Bodil; Liabakk, Nina-Beate; Hagen, Lars; Imai, K; Durandy, A; Slupphaug, Geir. (2004) Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells. Nucleic Acids Research (NAR)
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Pettersen, Henrik Sahlin; Galashevskaya, Anastasia; Doseth, Berit; Sousa, Mirta; Sarno, Antonio; Visnes, Torkild; Aas, Per Arne; Liabakk, Nina-Beate; Slupphaug, Geir; Sætrom, Pål. (2015) AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA Repair
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Prydz, Hans Peter B; Krokan, Hans E.. (2001) Genoverføring - Administrasjonsmåter, fordeler, mulige ulemper og farer. TDNLF
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Lehmann, A.R.; Bridges, B.A.; Hanawalt, P.C.; Johnson, R.T.; Kanaar, R.; Krokan, Hans E.; Seeberg, Erling Christen. (1996) Workshop on processing of DNA damage. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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Krokan, Hans Einar. (2002) Fromprotein folding to new enzymes. Tidsskrift for Den norske legeforening (Tidsskriftet)
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Otterlei, Marit; Kavli, Bodil; Standal, Rune; Skjelbred, Camilla; Bharati, Sangeeta; Krokan, Hans Einar. (2000) Repair of chromosomal abasic sites in vivo involves at least three different repair pathways. EMBO Journal
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Gilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Sousa, Mirta; Müller, Rebekka; Vågbø, Cathrine Broberg; Catterall, Tara; Liabakk, Nina-Beate; Slupphaug, Geir; Drabløs, Finn. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. Journal of Cell Biology
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Krokan, Hans Einar; Kavli, Bodil Merete; Ericsson, Ida; Galashevskaya, Anastasia; Sarno, Antonio; Aas, Per Arne; Vagbo, CB; Pettersen, Henrik P Sahlin; Slupphaug, Geir. (2013) Genomic uracil - potent mutagen but normal intermediate in adaptive immunity. The FEBS Journal
Konferanseabstract
Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Gederaas, Odrun Arna; Arum, Carl-Jørgen; Krokan, Hans Einar; Chen, Duan; Hjelme, Dag Roar; Svaasand, Lars O.. (2006) Monitoring of hALA induced PDT in rat bladder cancer by optical spectroscopy. Lasers in Surgery and Medicine
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Schønberg, Svanhild Margrethe Arentz; Jakobsen, Caroline Hild; Bremseth, Hilde; Olsen, Karina Standahl; Lundemo, Anne Gøril; Follestad, Turid; Sand, Kristin; Iversen, Jens Gustav; Krokan, Hans Einar. (2005) Endoplasmic reticulum stress induced by DHA leads to growth arrest of human colon cancer cells. Chemistry and Physics of Lipids
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Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin. (2014) Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLOS ONE
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Krokan, Hans Einar; Akbari, Mansour; Diaz, Javier Pena; Kavli, Bodil Merete; Otterlei, Marit; Ericsson, Madelene; Aarset, Harald; Andersen, Sonja Benedikte; Slupphaug, Geir. (2006) Base excision repair proteins in cancer prevention and acquired immune responses. The FEBS Journal
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Helander, Linda; Krokan, Hans Einar; Johnsson, Anders Carl G.; Gederaas, Odrun Arna; Plaetzer, Kristjan. (2014) Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro. Journal of Biomedical Optics
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Krokan, Hans Einar; Slupphaug, Geir. (2007) Repair of small base lesions in DNA - From molecular biology to phenotype - Preface. DNA Repair
Leder
Kavli, Bodil Merete; Andersen, Sonja Benedikte; Otterlei, Marit; Liabakk, Nina-Beate; Imai, K; Fischer, A; Durandy, A; Krokan, Hans Einar; Slupphaug, Geir. (2005) B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. Journal of Experimental Medicine (JEM)
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Andersen, Sonja Benedikte; Ericsson, Maria Elisabeth Madelene; Dai, HY; Diaz, Javier Pena; Slupphaug, Geir; Nilsen, H; Aarset, H; Krokan, Hans Einar. (2005) Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair
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Drabløs, Finn; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Kavli, Bodil; Bratlie, Marit Skyrud; Diaz, Javier Pena; Otterlei, Marit; Slupphaug, Geir; Krokan, Hans Einar. (2004) Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair
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Slupphaug, Geir; Kavli, Bodil; Krokan, Hans Einar. (2003) Interacting pathways that prevent and repair oxidative DNA damage. Mutation Research (DNA Repair)
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Andersen, Sonja Benedikte; Heine, T; Sneve, Ragnhild; Kønig, Imbritt; Krokan, Hans Einar; Epe, B; Nilsen, Hilde. (2005) Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis
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Imai, K; Slupphaug, Geir; Lee, W-I; Revy, P; Nonoyama, S; Catalan, N; Yel, L; Forveille, M; Kavli, Bodil; Krokan, Hans Einar. (2003) Uracil-DNA glycosylase deficiency profoundly impairs immunoglobulin class switch. Nature Immunology
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Hung, RJ; Mckay, J; Gaborieau, V; Boffetta, P; Chu, C; Field, JK; Krokan, Hans Einar; Vineis, P; Larthrop, M; Brennan, P. (2008) Detecting new genes for tobacco-related cancers - genomewide association study of lung cancer. European Journal of Cancer
Konferanseabstract
Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix; Lirussi, Lisa; SenGupta, Tanima; Tekin, Nuriye Basdag; Jobert, Laure; Alexandrov, Ludmil B.. (2017) Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. Scientific Reports
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Hanssen-Bauer, Audun; Garten, Karin Solvang-; Sundheim, Ottar; Diaz, Javier Pena; Andersen, Sonja Benedikte; Slupphaug, Geir; Krokan, Hans Einar; Wilson, David M.; Akbari, Mansour; Otterlei, Marit. (2011) XRCC1 Coordinates Disparate Responses and Multiprotein Repair Complexes Depending on the Nature and Context of the DNA Damage. Environmental and Molecular Mutagenesis
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Gabrielsen, Maiken Elvestad; Romundstad, Pål Richard; Langhammer, Arnulf; Krokan, Hans Einar; Skorpen, Frank. (2013) Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway. European Journal of Human Genetics
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Gederaas, Odrun Arna; Schønberg, Svanhild Margrethe Arentz; Ramstad, Ståle; Berg, Kristian; Johnsson, Anders Carl G.; Krokan, Hans Einar. (2005) Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. Photochemical and Photobiological Sciences
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Krokan, Hans Einar; Slupphaug, Geir. (2004) Novel aspects of macromolecular repair and relationship to human disease. Journal of Molecular Medicine
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Nilsen, Hilde; Stamp, G; Andersen, Sonja; Hrivnak, G; Krokan, Hans Einar; Lindahl, T; Barnes, D.E. (2003) Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene
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Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature
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Doseth, Berit; Visnes, Torkild; Wallenius, Anders; Ericsson, Ida; Sarno, Antonio; Pettersen, Henrik Sahlin; Flatberg, Arnar; Catterall, Tara Cherie; Slupphaug, Geir; Krokan, Hans Einar. (2011) Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity: SPECIES DIFFERENCES BETWEEN MAN AND MOUSE. Journal of Biological Chemistry
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Nilsen, Hilde; Rosewell, Ian; Robins, Peter; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Daly, Graham; Krokan, Hans Einar; Lindahl, Tomas; Barnes, Deborah E.. (2000) URACIL-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication. Molecular Cell
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Rudra, Parveen K.; Krokan, Hans Einar. (1999) Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells. Anticancer Research
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Otterlei, Marit; Warbrick, Emma; Nagelhus, Toril; Haug, Terje; Slupphaug, Geir; Akbari, Mansour; Aas, Per Arne; Steinsbekk, Kristin; Bakke, Oddmund; Krokan, Hans Einar. (1999) Post-replicative base excision repair in replication foci. EMBO Journal
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Krokan, Hans Einar. (2001) Kong Olav V's kreftforskningspris til Erling Seeberg. NBS-nytt
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Auerbach, Paul; Bennett, Richard A.O.; Bailey, Elisabeth A.; Krokan, Hans Einar; Demple, Bruce. (2005) Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA. Proceedings of the National Academy of Sciences of the United States of America (PNAS)
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Torseth, Kathrin; Doseth, Berit; Hagen, Lars; Olaisen, Camilla; Liabakk, Nina-Beate; Græsmann, Heidi; Durandy, Anne; Otterlei, Marit; Krokan, Hans Einar; Kavli, Bodil Merete. (2012) The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA. DNA Repair
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Waldum, Helge; Sandvik, AK; Angelsen, Anders; Krokan, Hans Einar; Falkmer, S. (1999) Re. Editorial entitled "The origin of gut and pancreatic neuroendocrine (APUD) cells-the last word?". Journal of Pathology
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Parikh, S. Sudip; Mol, Clifford D.; Slupphaug, Geir; Bharati, Sangeta; Krokan, Hans Einar; Yainer, John A.. (1998) Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase. EMBO Journal
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Krokan, Hans Einar; Slupphaug, Geir. (1998) DNA-reparasjonsenzymer og deres gener. Tidsskrift for Den norske legeforening (Tidsskriftet)
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Hagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Liabakk, Nina-Beate; Sundheim, Ottar; Diaz, Javier Pena; Otterlei, Marit; Hørning, Ole; Jensen, Ole N. (2008) Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO Journal
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Krokan, Hans Einar; Nilsen, Hilde. (2001) Base excision repair in a network of defence and tolerance. Carcinogenesis
Vitenskapelig artikkel
Vågbø, Cathrine Broberg; Svaasand, Eva Kathrine; Aas, Per Arne; Krokan, Hans Einar. (2012) Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response. DNA Repair
Vitenskapelig artikkel
Holthe, Monica; Råkvåg, Trude Teoline; Klepstad, Pål; Idle, Jefrrey R.; Kaasa, Stein; Krokan, Hans Einar; Skorpen, Frank. (2002) Sequence variationin the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphins (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. The Pharmacogenomics Journal
Vitenskapelig artikkel
Krokan, Hans Einar; Slupphaug, Geir. (2002) Damage and repair of DNA in mammalian cells-emphasis on oxidative damage. Proceedings from International Symposium "Natural Ionising Radiation and Health". Det Norske Videnskaps-Akademi : proceedings
Vitenskapelig artikkel
Krokan, Hans Einar; Drabløs, Finn; Slupphaug, Geir. (2002) Uracil in DNA, occurrence, consequences and repair. Oncogene
Vitenskapelig artikkel
Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde; Skorpen, Frank; Aas, Per Arne; Hagen, Lars; Krokan, Hans Einar; Slupphaug, Geir. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry
Vitenskapelig artikkel
Hu, Yi; Ericsson, Ida; Doseth, Berit; Liabakk, Nina-Beate; Krokan, Hans Einar; Kavli, Bodil Merete. (2014) Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors. Experimental Cell Research
Vitenskapelig artikkel
Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor; Leszczynska, G; Malkiewicz, A; Krokan, Hans Einar; Kirpekar, F; Klungland, Arne. (2011) ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications
Vitenskapelig artikkel
Visnes, Torkild; Doseth, Berit; Pettersen, Henrik Sahlin; Hagen, Lars; Sousa, Mirta; Akbari, Mansour; Otterlei, Marit; Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2009) Uracil in DNA and its processing by different DNA glycosylases. Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel

Bøker

Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil - Evolution, Biology, Immunology and Disease. World Scientific
Faglig monografi
Krokan, Hans Einar; Skorpen, Frank; Otterlei, Marit; Bharati, S; Steinsbekk, Kristin; Nilsen, Hilde; Hernes, T Nagelhus-; Haug, T; Aas, Per A; Akbari, M. (1998) Human uracil-DNA glycosylase:gene structure, regulation and structural basis for catalysis. Plenum Press
Faglig monografi
Smeland, Erlend; Prydz, Hans; Ørstadvik, Karen Helene; Frøland, Stig; Aamdal, Steinar; Myklebost, Ola; Apold, Jaran; Børresen-Dale, Anne-Lise; Seeberg, Erling; Hovig, Eivind. (2000) Genterapi Status og fremtidige muligheter innen klinisk medisin. Lobo Grafisk AS
Faglig monografi
Krokan, Hans Einar; Valla, Svein; Bones, Atle. (1993) Markørgener - sikkerhet for helse og miljø. Direktoratet for naturforvaltning
Faglig monografi
Krokan, Hans Einar. (1993) Omega-3 fatty acids : metabolism and biological effects. Birkhæuser Verlag
Faglig monografi

Del av bok/rapport

Kavli, Bodil Merete; Slupphaug, Geir; Krokan, Hans Einar. (2020) Genomic Uracil in Biology, Immunity and Cancer.
Vitenskapelig kapittel
Krokan, Hans Einar; Standal, Rune; Bharati, Sangeeta; Otterlei, Marit; Haug, Terje; Slupphaug, Geir; Skorpen, Frank. (1997) Uracil in DNA and the family of concerved uracil DNA glycosylases.
Vitenskapelig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Sarno, Antonio; Slupphaug, Geir. (2018) Enzymology of Genomic Uracil Repair.
Faglig kapittel
Slupphaug, Geir; Krokan, Hans Einar. (2018) Genomic Uracil – Valuable Tool in Molecular Biology but Inherent Problem in Sequencing of Ancient DNA.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir; Drabløs, Finn. (2018) The Earth, Life and Genomic Uracil.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) DNA Repair is Integrated with Many Cellular Processes.
Faglig kapittel
Krokan, Hans Einar; Kavli, Bodil Merete; Slupphaug, Geir. (2018) Viral Uracil - Uracil DNA glycosylases and dUTPases.
Faglig kapittel
Slupphaug, Geir; Kavli, Bodil Merete; Krokan, Hans Einar. (2018) Routes to Uracil in DNA.
Faglig kapittel
Krokan, Hans Einar; Slupphaug, Geir; Kavli, Bodil Merete. (2017) Genomic Uracil-Dangers and Benefits in processing.
Vitenskapelig kapittel
Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Gederaas, Odrun Arna; Krokan, Hans Einar; Hjelme, Dag Roar; Svaasand, Lars O.. (2007) In vitro study on methemoglobin formation in erythrocytes following hexyl-aminolevulinate induced photodynamic therapy.
Vitenskapelig kapittel
Smeland, Erlend B; Prydz, Hans Peter B; Ørstavik, Karen Helene; Frøland, Stig Sophus; Aamdal, Steinar; Myklebost, Ola; Apold, J; Børresen-Dale, Anne-Lise; Seeberg, Erling Christen; Hovig, Eivind. (2000) Genterapi. Status og fremtidige muligheter innen klinisk medisin.
Vitenskapelig kapittel
Krokan, Hans Einar. (1999) Kapittel 16: Vann og elektrolytter.
Vitenskapelig kapittel

Studentoppgave eller avhandling

Monsen, Vivi A Talstad; Krokan, Hans Einar; Aas, Per Arne. (2010) Mechanisms of alkylation damage repair by human AlkB homologues. Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
Grøsvik, K; Slupphaug, Geir; Krokan, Hans Einar. (2002) "Characterisation of uracil-exising enzyme activities in organ extracts from UNG knockout and wild-type mice.". NTNU
Masteroppgave
Nygård, M; Nilsen, M; Remseth, V; Slupphaug, Geir; Krokan, Hans Einar. (2002) Uttrykk av det membran-modifiserende enzymet UDPDG i E.coli som funksjon av dyrkningsbetingelser og induksjon av DNA-skader. [Mangler utgivernavn]
Masteroppgave
Overland, Hilde Bremseth; Schønberg, Svanhild Margrethe Arentz; Krokan, Hans Einar. (2013) ER stress, reactive oxygen species and autophagy in colon cancer cells treated with polyunsaturated marine fatty acids. Norges teknisk-naturvitenskapelige universitet
Doktoravhandling
Helander, Linda; Krokan, Hans Einar; Gederaas, Odrun Arna; Johnsson, Anders Carl G.; Chen, Duan. (2015) Hexylaminolevulinate Photodynamic Treatment of Cancer Cell Lines. PhD Thesis. Tapir Akademisk Forlag
Doktoravhandling
Krokan, Hans Einar; Visnes, Torkild. (2009) DNA Excision repair of uracil and 5-fluorouracil in human cancer cell lines. Det medisinske fakultet, NTNU
Doktoravhandling

Formidling