Sjoerd Hak
Om
Nanomedicines are extensively studied for in vivo therapeutic and diagnostic applications. Although several nanodrugs have been clinically approved and many are in clinical trials, the medical potential of these agents remains to be fully exploited. There are multiple reasons for this unsatisfactory utilization, but an important underlying issue is incomplete understanding of nanoparticle in vivo applications.
In my group, we attempt to define the gaps in the knowledge about nanoparticle ‘in vivo behavior’, and develop and use a range of methods to address these issues. At the heart of our effort lie various in vivo imaging modalities, like whole animal optical imaging, magnetic resonance imaging, and intravital microscopy. Especially intravital microscopy has proven extremely powerful for studying nanoparticle drug release and tumor targeting kinetics, as well as nanoparticle interactions with various cells in real-time. For ex vivo analysis, we have implemented state-of-the-art flow cytometry approaches allowing us to map interactions of administered nanoparticles with numerous cell types. Using this combination of in vivo and ex vivo methods, we are now discovering pivotal roles for various cells of the immune system in nanoparticle in vivo applications.
Using the new and exciting insights we gained over recent years, we are aiming to develop novel nanotherapeutic approaches with a focus on cancer. At the same time, we continue to increase our understanding of nanoparticles’ complex ‘in vivo behavior’.
Publikasjoner
2022
-
Momoh, Jeffrey;
Kapsokalyvas, Dimitrios;
Vogt, Michael;
Hak, Sjoerd;
Kiessling, Fabian;
van Zandvoort, Marc;
Lammers, Twan;
Sofias, Alexandros Marios.
(2022)
Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes.
Advanced Drug Delivery Reviews.
volum 189.
Vitenskapelig oversiktsartikkel/review
2021
-
Mildner, Robert;
Hak, Sjoerd;
Parot, Jérémie;
Hyldbakk, Astrid;
Borgos, Sven Even F.;
Some, Dan;
Johann, Cristoph;
Caputo, Fanny.
(2021)
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery.
European journal of pharmaceutics and biopharmaceutics.
volum 163.
Vitenskapelig artikkel
-
Sofias, Alexandros Marios;
Bjørkøy, Geir;
Ochando, Jordi;
Sønstevold, Linda;
Hegvik, Maria;
Davies, Catharina de Lange;
Haraldseth, Olav;
Lammers, Twan;
Mulder, Willem J. M.;
Hak, Sjoerd.
(2021)
Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes.
Advanced Science.
volum 8 (13).
Vitenskapelig artikkel
2020
-
Molska, Alicja;
Nyman, Axel Karl Gottfrid;
Sofias, Alexandros Marios;
Kristiansen, Kåre Andre;
Hak, Sjoerd;
Widerøe, Marius.
(2020)
In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations.
European journal of pharmaceutics and biopharmaceutics.
volum 152.
Vitenskapelig artikkel
-
Priem, Bram;
van Leent, Mandy M. T.;
Teunissen, Abraham J. P.;
Sofias, Alexandros Marios;
Mourits, Vera P.;
Willemsen, Lisa;
Klein, Emma D.;
Oosterwijk, Roderick S.;
Meerwaldt, Anu E.;
Munitz, Jazz;
Prévot, Geoffrey;
Verschuur, Anna Vera;
Nauta, Sheqouia A.;
van Leeuwen, Esther M.;
Fisher, Elizabeth L.;
de Jong, Karen A.M.;
Zhao, Yiming;
Toner, Yohana C.;
Soultanidis, Georgios.
(2020)
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Cell.
volum 183 (3).
Vitenskapelig artikkel
-
Senders, Max L.;
Meerwaldt, Anu E.;
van Leent, Mandy M. T.;
Sanchez-Gaytan, Brenda L.;
van de Voort, Jan C.;
Toner, Yohana C.;
Maier, Alexander;
Klein, Emma D.;
Sullivan, Nathaniel A. T.;
Sofias, Alexandros Marios;
Groenen, Hannah;
Faries, Christopher;
Oosterwijk, Roderick S.;
van Leeuwen, Esther M.;
Fay, Francois;
Chepurko, Elena;
Reiner, Thomas;
Duivenvoorden, Raphael;
Zangi, Lior.
(2020)
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging.
Nature Nanotechnology.
volum 15 (5).
Vitenskapelig artikkel
-
Sofias, Alexandros Marios;
Toner, Yohana C.;
Meerwaldt, Anu E.;
van Leent, Mandy M. T.;
Soultanidis, Georgios;
Elschot, Mattijs;
Gonai, Haruki;
Grendstad, Kristin;
Flobak, Åsmund;
Neckmann, Ulrike;
Wolowczyk, Camilla;
Fisher, Elizabeth L.;
Reiner, Thomas;
Davies, Catharina de Lange;
Bjørkøy, Geir;
Teunissen, Abraham J. P.;
Ochando, Jordi;
Pérez-Medina, Carlos;
Mulder, Willem J. M..
(2020)
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking.
ACS Nano.
volum 14 (7).
Vitenskapelig artikkel
2019
-
Combes, Francis;
Sofias, Alexandros Marios;
Mc Cafferty, Séan;
Huysmans, Hanne;
De Temmerman, Joyca;
Hak, Sjoerd;
Meyer, Evelyne;
Sanders, Niek N.
(2019)
Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes.
Cancers.
volum 11 (11).
Vitenskapelig artikkel
-
Sofias, Alexandros Marios;
Åslund, Andreas;
Hagen, Nils;
Grendstad, Kristin;
Hak, Sjoerd.
(2019)
Simple and robust intravital microscopy procedures in hybrid TIE2GFP-BALB/c transgenic mice.
Molecular Imaging and Biology.
volum 22 (3).
Vitenskapelig artikkel
2018
-
Sofias, Alexandros Marios;
Andreassen, Trygve;
Hak, Sjoerd.
(2018)
Nanoparticle Ligand-Decoration Procedures Affect in Vivo Interactions with Immune Cells.
Molecular Pharmaceutics.
volum 15 (12).
Vitenskapelig artikkel
-
Witzigmann, Dominik;
Hak, Sjoerd;
van der Meel, Roy.
(2018)
Translating nanomedicines: Thinking beyond materials? A young investigator's reply to `The Novelty Bubble’.
Journal of Controlled Release.
volum 290.
Vitenskapelig artikkel
2017
-
Perez-Medina, Carlos;
Hak, Sjoerd;
Reiner, Thomas;
Fayad, Zahi A;
Nahrendorf, Matthias;
Mulder, Willem J. M..
(2017)
Integrating nanomedicine and imaging.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.
volum 375 (2107).
Vitenskapelig oversiktsartikkel/review
-
Sanchez-Gaytan, Brenda L;
Fay, Francois;
Hak, Sjoerd;
Alaarg, Amr;
Fayad, Zahi A;
Perez-Medina, Carlos;
Mulder, Willem J M;
Zhao, Yiming.
(2017)
Real-Time Monitoring of Nanoparticle Formation by FRET Imaging.
Angewandte Chemie International Edition.
volum 56 (11).
Vitenskapelig artikkel
-
Singh, Gurvinder;
McDonagh, Birgitte Hjelmeland;
Hak, Sjoerd;
Peddis, Davide;
Bandyopadhyay, Sulalit;
Sandvig, Ioanna;
Sandvig, Axel;
Glomm, Wilhelm.
(2017)
Synthesis of gadolinium oxide nanodisks and gadolinium doped iron oxide nanoparticles for MR contrast agents.
Journal of materials chemistry. B.
volum 5 (3).
Vitenskapelig artikkel
2016
-
McDonagh, Birgitte Hjelmeland;
Singh, Gurvinder;
Hak, Sjoerd;
Bandyopadhyay, Sulalit;
Augestad, Ingrid Lovise;
Peddis, Davide;
Sandvig, Ioanna;
Sandvig, Axel;
Glomm, Wilhelm.
(2016)
L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles.
Small.
volum 12 (3).
Vitenskapelig artikkel
-
Snipstad, Sofie;
Hak, Sjoerd;
Baghirov, Habib;
Sulheim, Einar;
Mørch, Ýrr Asbjørg;
Lelu, Sylvie;
von Haartman, Eva;
Bäck, Marcus;
Nilsson, Peter R;
Klymchenko, Andrey S;
Davies, Ruth Catharina de Lange;
Åslund, Andreas.
(2016)
Labeling nanoparticles: Dye leakage and altered cellular uptake.
Cytometry Part A.
volum 91 (8).
Vitenskapelig artikkel
-
Zhao, Yiming;
Fay, Francois;
Hak, Sjoerd;
Manuel Perez-Aguilar, Jose;
Sanchez-Gaytan, Brenda L;
Goode, Brandon;
Duivenvoorden, Raphael;
Davies, Ruth Catharina de Lange;
Bjørkøy, Astrid;
Weinstein, Harel;
Fayad, Zahi A;
Perez-Medina, Carlos;
Mulder, Willem J M.
(2016)
Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy.
Nature Communications.
volum 7.
Vitenskapelig artikkel
2015
-
Hak, Sjoerd;
Garaiova, Zuzana;
Olsen, Linda Therese;
Nilsen, Asbjørn Magne;
Davies, Catharina De Lange.
(2015)
The effects of oil-in-water nanoemulsion polyethylene glycol surface density on intracellular stability, pharmacokinetics, and biodistribution in tumor bearing mice.
Pharmaceutical Research.
volum 32 (4).
Vitenskapelig artikkel
-
Hak, Sjoerd;
Goa, Pål Erik;
Stenmark, Sebastian Tegnér;
Bjerkholt, Frøydis F;
Haraldseth, Olav.
(2015)
Transverse relaxivity of iron oxide nanocrystals clustered in nanoemulsions: Experiment and theory.
Magnetic Resonance in Medicine.
volum 74 (3).
Vitenskapelig artikkel
-
Mørch, Ýrr Asbjørg;
Hansen, Rune;
Berg, Sigrid;
Åslund, Andreas;
Glomm, Wilhelm;
Eggen, Siv;
Schmid, Ruth;
Johnsen, Heidi;
Kubowicz, Stephan;
Snipstad, Sofie;
Sulheim, Einar;
Hak, Sjoerd;
Singh, Gurvinder;
McDonagh, Birgitte Hjelmeland;
Blom, Hans;
Davies, Ruth Catharina de Lange;
Stenstad, Per Martin.
(2015)
Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery.
Contrast Media & Molecular Imaging.
volum 10 (5).
Vitenskapelig artikkel
-
Åslund, Andreas;
Berg, Sigrid;
Hak, Sjoerd;
Mørch, Ýrr Asbjørg;
Torp, Sverre Helge;
Sandvig, Axel;
Widerøe, Marius;
Hansen, Rune;
Davies, Ruth Catharina de Lange.
(2015)
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles.
Journal of Controlled Release.
volum 220.
Vitenskapelig artikkel
2014
-
Hak, Sjoerd;
Cebulla, Jana;
Huuse, Else Marie;
Davies, Catharina de Lange;
Mulder, Willem J. M.;
Larsson, Henrik;
Haraldseth, Olav.
(2014)
Periodicity in tumor vasculature targeting kinetics of ligand-functionalized nanoparticles studied by dynamic contrast enhanced magnetic resonance imaging and intravital microscopy.
Angiogenesis.
volum 17 (1).
Vitenskapelig artikkel
2013
-
Garaiova, Zuzana;
Hak, Sjoerd;
Davies, Catharina De Lange;
Hianik, Tibor.
(2013)
Interaction of nanoparticles with biomembranes and lipid vesicles modified by artificial receptors.
European Biophysics Journal.
volum 42.
Sammendrag/abstract
-
Hak, Sjoerd.
(2013)
Improving nanoparticles for battling cancer.
Nettsider (opplysningsmateriale)
-
Zhao, Yiming;
van Rooy, Inge;
Hak, Sjoerd;
Fay, Francois;
Tang, Jun;
Davies, Catharina De Lange;
Skobe, Mihaela;
Fisher, Edward Allen;
Radu, Aurelian;
Fayad, Zahi A;
Donega, Celso de Mello;
Meijerink, Andries;
Mulder, Willem J.M..
(2013)
Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice.
ACS Nano.
volum 7 (11).
Vitenskapelig artikkel
2012
-
Hak, Sjoerd;
Helgesen, Emily;
Hektoen, Helga;
Huuse, Else Marie;
Jarzyna, Peter A.;
Mulder, Willem J.M.;
Haraldseth, Olav;
Davies, Catharina De Lange.
(2012)
The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-Directed Tumor Targeting Studied in Vivo by Dual Modality Imaging.
ACS Nano.
volum 6 (6).
Vitenskapelig artikkel
2010
-
Hak, Sjoerd;
Reitan, Nina Kristine;
Haraldseth, Olav;
Davies, Catharina De Lange.
(2010)
Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles.
Angiogenesis.
volum 13 (2).
Vitenskapelig oversiktsartikkel/review
2009
-
Hak, Sjoerd;
Sanders, Erik H.M.;
Agrawal, Prashant;
Langereis, Sander;
Grull, Holger;
Keizer, Henk M.;
Arena, Francesca;
Terreno, Enzo;
Strijkers, Gustav J.;
Nicolay, Klaas.
(2009)
A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging.
European journal of pharmaceutics and biopharmaceutics.
volum 72.
Vitenskapelig artikkel
-
Kok, Maarten B.;
Hak, Sjoerd;
Mulder, Willem J.M.;
van der Schaft, Daisy W.;
Strijkers, Gustav J.;
Nicolay, Klaas.
(2009)
Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity.
Magnetic Resonance in Medicine.
volum 61 (1022).
Vitenskapelig artikkel
-
Strijkers, Gustav J.;
Hak, Sjoerd;
Kok, Maarten B.;
Springer, Charles;
Nicolay, Klaas.
(2009)
Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents.
Magnetic Resonance in Medicine.
volum 61.
Vitenskapelig artikkel
2008
-
Mulder, Willem J.M.;
Cormode, David P.;
Hak, Sjoerd;
Lobatto, Mark E.;
Silvera, Stefano;
Fayad, Zahi A.
(2008)
Multimodality nanotracers for cardiovascular applications.
Nature Clinical Practice Cardiovascular Medicine.
volum 5.
Vitenskapelig oversiktsartikkel/review
Tidsskriftspublikasjoner
-
Momoh, Jeffrey;
Kapsokalyvas, Dimitrios;
Vogt, Michael;
Hak, Sjoerd;
Kiessling, Fabian;
van Zandvoort, Marc;
Lammers, Twan;
Sofias, Alexandros Marios.
(2022)
Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes.
Advanced Drug Delivery Reviews.
volum 189.
Vitenskapelig oversiktsartikkel/review
-
Mildner, Robert;
Hak, Sjoerd;
Parot, Jérémie;
Hyldbakk, Astrid;
Borgos, Sven Even F.;
Some, Dan;
Johann, Cristoph;
Caputo, Fanny.
(2021)
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery.
European journal of pharmaceutics and biopharmaceutics.
volum 163.
Vitenskapelig artikkel
-
Sofias, Alexandros Marios;
Bjørkøy, Geir;
Ochando, Jordi;
Sønstevold, Linda;
Hegvik, Maria;
Davies, Catharina de Lange;
Haraldseth, Olav;
Lammers, Twan;
Mulder, Willem J. M.;
Hak, Sjoerd.
(2021)
Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes.
Advanced Science.
volum 8 (13).
Vitenskapelig artikkel
-
Molska, Alicja;
Nyman, Axel Karl Gottfrid;
Sofias, Alexandros Marios;
Kristiansen, Kåre Andre;
Hak, Sjoerd;
Widerøe, Marius.
(2020)
In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations.
European journal of pharmaceutics and biopharmaceutics.
volum 152.
Vitenskapelig artikkel
-
Priem, Bram;
van Leent, Mandy M. T.;
Teunissen, Abraham J. P.;
Sofias, Alexandros Marios;
Mourits, Vera P.;
Willemsen, Lisa;
Klein, Emma D.;
Oosterwijk, Roderick S.;
Meerwaldt, Anu E.;
Munitz, Jazz;
Prévot, Geoffrey;
Verschuur, Anna Vera;
Nauta, Sheqouia A.;
van Leeuwen, Esther M.;
Fisher, Elizabeth L.;
de Jong, Karen A.M.;
Zhao, Yiming;
Toner, Yohana C.;
Soultanidis, Georgios.
(2020)
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Cell.
volum 183 (3).
Vitenskapelig artikkel
-
Senders, Max L.;
Meerwaldt, Anu E.;
van Leent, Mandy M. T.;
Sanchez-Gaytan, Brenda L.;
van de Voort, Jan C.;
Toner, Yohana C.;
Maier, Alexander;
Klein, Emma D.;
Sullivan, Nathaniel A. T.;
Sofias, Alexandros Marios;
Groenen, Hannah;
Faries, Christopher;
Oosterwijk, Roderick S.;
van Leeuwen, Esther M.;
Fay, Francois;
Chepurko, Elena;
Reiner, Thomas;
Duivenvoorden, Raphael;
Zangi, Lior.
(2020)
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging.
Nature Nanotechnology.
volum 15 (5).
Vitenskapelig artikkel
-
Sofias, Alexandros Marios;
Toner, Yohana C.;
Meerwaldt, Anu E.;
van Leent, Mandy M. T.;
Soultanidis, Georgios;
Elschot, Mattijs;
Gonai, Haruki;
Grendstad, Kristin;
Flobak, Åsmund;
Neckmann, Ulrike;
Wolowczyk, Camilla;
Fisher, Elizabeth L.;
Reiner, Thomas;
Davies, Catharina de Lange;
Bjørkøy, Geir;
Teunissen, Abraham J. P.;
Ochando, Jordi;
Pérez-Medina, Carlos;
Mulder, Willem J. M..
(2020)
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking.
ACS Nano.
volum 14 (7).
Vitenskapelig artikkel
-
Combes, Francis;
Sofias, Alexandros Marios;
Mc Cafferty, Séan;
Huysmans, Hanne;
De Temmerman, Joyca;
Hak, Sjoerd;
Meyer, Evelyne;
Sanders, Niek N.
(2019)
Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes.
Cancers.
volum 11 (11).
Vitenskapelig artikkel
-
Sofias, Alexandros Marios;
Åslund, Andreas;
Hagen, Nils;
Grendstad, Kristin;
Hak, Sjoerd.
(2019)
Simple and robust intravital microscopy procedures in hybrid TIE2GFP-BALB/c transgenic mice.
Molecular Imaging and Biology.
volum 22 (3).
Vitenskapelig artikkel
-
Sofias, Alexandros Marios;
Andreassen, Trygve;
Hak, Sjoerd.
(2018)
Nanoparticle Ligand-Decoration Procedures Affect in Vivo Interactions with Immune Cells.
Molecular Pharmaceutics.
volum 15 (12).
Vitenskapelig artikkel
-
Witzigmann, Dominik;
Hak, Sjoerd;
van der Meel, Roy.
(2018)
Translating nanomedicines: Thinking beyond materials? A young investigator's reply to `The Novelty Bubble’.
Journal of Controlled Release.
volum 290.
Vitenskapelig artikkel
-
Perez-Medina, Carlos;
Hak, Sjoerd;
Reiner, Thomas;
Fayad, Zahi A;
Nahrendorf, Matthias;
Mulder, Willem J. M..
(2017)
Integrating nanomedicine and imaging.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.
volum 375 (2107).
Vitenskapelig oversiktsartikkel/review
-
Sanchez-Gaytan, Brenda L;
Fay, Francois;
Hak, Sjoerd;
Alaarg, Amr;
Fayad, Zahi A;
Perez-Medina, Carlos;
Mulder, Willem J M;
Zhao, Yiming.
(2017)
Real-Time Monitoring of Nanoparticle Formation by FRET Imaging.
Angewandte Chemie International Edition.
volum 56 (11).
Vitenskapelig artikkel
-
Singh, Gurvinder;
McDonagh, Birgitte Hjelmeland;
Hak, Sjoerd;
Peddis, Davide;
Bandyopadhyay, Sulalit;
Sandvig, Ioanna;
Sandvig, Axel;
Glomm, Wilhelm.
(2017)
Synthesis of gadolinium oxide nanodisks and gadolinium doped iron oxide nanoparticles for MR contrast agents.
Journal of materials chemistry. B.
volum 5 (3).
Vitenskapelig artikkel
-
McDonagh, Birgitte Hjelmeland;
Singh, Gurvinder;
Hak, Sjoerd;
Bandyopadhyay, Sulalit;
Augestad, Ingrid Lovise;
Peddis, Davide;
Sandvig, Ioanna;
Sandvig, Axel;
Glomm, Wilhelm.
(2016)
L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles.
Small.
volum 12 (3).
Vitenskapelig artikkel
-
Snipstad, Sofie;
Hak, Sjoerd;
Baghirov, Habib;
Sulheim, Einar;
Mørch, Ýrr Asbjørg;
Lelu, Sylvie;
von Haartman, Eva;
Bäck, Marcus;
Nilsson, Peter R;
Klymchenko, Andrey S;
Davies, Ruth Catharina de Lange;
Åslund, Andreas.
(2016)
Labeling nanoparticles: Dye leakage and altered cellular uptake.
Cytometry Part A.
volum 91 (8).
Vitenskapelig artikkel
-
Zhao, Yiming;
Fay, Francois;
Hak, Sjoerd;
Manuel Perez-Aguilar, Jose;
Sanchez-Gaytan, Brenda L;
Goode, Brandon;
Duivenvoorden, Raphael;
Davies, Ruth Catharina de Lange;
Bjørkøy, Astrid;
Weinstein, Harel;
Fayad, Zahi A;
Perez-Medina, Carlos;
Mulder, Willem J M.
(2016)
Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy.
Nature Communications.
volum 7.
Vitenskapelig artikkel
-
Hak, Sjoerd;
Garaiova, Zuzana;
Olsen, Linda Therese;
Nilsen, Asbjørn Magne;
Davies, Catharina De Lange.
(2015)
The effects of oil-in-water nanoemulsion polyethylene glycol surface density on intracellular stability, pharmacokinetics, and biodistribution in tumor bearing mice.
Pharmaceutical Research.
volum 32 (4).
Vitenskapelig artikkel
-
Hak, Sjoerd;
Goa, Pål Erik;
Stenmark, Sebastian Tegnér;
Bjerkholt, Frøydis F;
Haraldseth, Olav.
(2015)
Transverse relaxivity of iron oxide nanocrystals clustered in nanoemulsions: Experiment and theory.
Magnetic Resonance in Medicine.
volum 74 (3).
Vitenskapelig artikkel
-
Mørch, Ýrr Asbjørg;
Hansen, Rune;
Berg, Sigrid;
Åslund, Andreas;
Glomm, Wilhelm;
Eggen, Siv;
Schmid, Ruth;
Johnsen, Heidi;
Kubowicz, Stephan;
Snipstad, Sofie;
Sulheim, Einar;
Hak, Sjoerd;
Singh, Gurvinder;
McDonagh, Birgitte Hjelmeland;
Blom, Hans;
Davies, Ruth Catharina de Lange;
Stenstad, Per Martin.
(2015)
Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery.
Contrast Media & Molecular Imaging.
volum 10 (5).
Vitenskapelig artikkel
-
Åslund, Andreas;
Berg, Sigrid;
Hak, Sjoerd;
Mørch, Ýrr Asbjørg;
Torp, Sverre Helge;
Sandvig, Axel;
Widerøe, Marius;
Hansen, Rune;
Davies, Ruth Catharina de Lange.
(2015)
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles.
Journal of Controlled Release.
volum 220.
Vitenskapelig artikkel
-
Hak, Sjoerd;
Cebulla, Jana;
Huuse, Else Marie;
Davies, Catharina de Lange;
Mulder, Willem J. M.;
Larsson, Henrik;
Haraldseth, Olav.
(2014)
Periodicity in tumor vasculature targeting kinetics of ligand-functionalized nanoparticles studied by dynamic contrast enhanced magnetic resonance imaging and intravital microscopy.
Angiogenesis.
volum 17 (1).
Vitenskapelig artikkel
-
Garaiova, Zuzana;
Hak, Sjoerd;
Davies, Catharina De Lange;
Hianik, Tibor.
(2013)
Interaction of nanoparticles with biomembranes and lipid vesicles modified by artificial receptors.
European Biophysics Journal.
volum 42.
Sammendrag/abstract
-
Zhao, Yiming;
van Rooy, Inge;
Hak, Sjoerd;
Fay, Francois;
Tang, Jun;
Davies, Catharina De Lange;
Skobe, Mihaela;
Fisher, Edward Allen;
Radu, Aurelian;
Fayad, Zahi A;
Donega, Celso de Mello;
Meijerink, Andries;
Mulder, Willem J.M..
(2013)
Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice.
ACS Nano.
volum 7 (11).
Vitenskapelig artikkel
-
Hak, Sjoerd;
Helgesen, Emily;
Hektoen, Helga;
Huuse, Else Marie;
Jarzyna, Peter A.;
Mulder, Willem J.M.;
Haraldseth, Olav;
Davies, Catharina De Lange.
(2012)
The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-Directed Tumor Targeting Studied in Vivo by Dual Modality Imaging.
ACS Nano.
volum 6 (6).
Vitenskapelig artikkel
-
Hak, Sjoerd;
Reitan, Nina Kristine;
Haraldseth, Olav;
Davies, Catharina De Lange.
(2010)
Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles.
Angiogenesis.
volum 13 (2).
Vitenskapelig oversiktsartikkel/review
-
Hak, Sjoerd;
Sanders, Erik H.M.;
Agrawal, Prashant;
Langereis, Sander;
Grull, Holger;
Keizer, Henk M.;
Arena, Francesca;
Terreno, Enzo;
Strijkers, Gustav J.;
Nicolay, Klaas.
(2009)
A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging.
European journal of pharmaceutics and biopharmaceutics.
volum 72.
Vitenskapelig artikkel
-
Kok, Maarten B.;
Hak, Sjoerd;
Mulder, Willem J.M.;
van der Schaft, Daisy W.;
Strijkers, Gustav J.;
Nicolay, Klaas.
(2009)
Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity.
Magnetic Resonance in Medicine.
volum 61 (1022).
Vitenskapelig artikkel
-
Strijkers, Gustav J.;
Hak, Sjoerd;
Kok, Maarten B.;
Springer, Charles;
Nicolay, Klaas.
(2009)
Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents.
Magnetic Resonance in Medicine.
volum 61.
Vitenskapelig artikkel
-
Mulder, Willem J.M.;
Cormode, David P.;
Hak, Sjoerd;
Lobatto, Mark E.;
Silvera, Stefano;
Fayad, Zahi A.
(2008)
Multimodality nanotracers for cardiovascular applications.
Nature Clinical Practice Cardiovascular Medicine.
volum 5.
Vitenskapelig oversiktsartikkel/review
INFORMASJONSMATR
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Hak, Sjoerd.
(2013)
Improving nanoparticles for battling cancer.
Nettsider (opplysningsmateriale)
Formidling
2022
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PosterBokil, Ansooya Avinash; Børkja , Mathieu Le Boulvais ; Wolowczyk, Camilla; Bofin, Anna Mary; Hak, Sjoerd; Giambelluca, Miriam Soledad. (2022) DISCOVERING MARKERS THAT IDENTIFY PRO-METASTATIC IMMUNE CELL SUBSETS. European Society for Medical Oncology Immuno-Oncology Congress . European Society for Medical Oncology; Geneva. 2022-12-07 - 2022-12-09.
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PosterWolowczyk, Camilla; Bokil, Ansooya Avinash; Hak, Sjoerd; Bjørkøy, Geir; Giambelluca, Miriam Soledad. (2022) A new role for CXCL3 in shaping the metastatic tumor microenvironment. ESMO IMMUNO-ONCOLOGY CONGRESS 2022 ; 2022-12-07 - 2022-12-09.
2021
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IntervjuBorgos, Sven Even F.; Benjaminsen, Christina; Hak, Sjoerd. (2021) Hvor sikre er koronavaksinene?. Gemini.no [Internett]. 2021-01-14.
2019
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Faglig foredragSofias, Alexandros Marios; Pérez-Medina, Carlos; Mulder, Willem J.M.; Hak, Sjoerd. (2019) Unraveling the intricate in vivo fate of active-targeting nanomedicines. NanoSymposium 2019 ; 2019-10-16 - 2019-10-17.
2018
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PosterHak, Sjoerd; Hagen, Nils; Sofias, Alexandros Marios; Åslund, Andreas; Davies, Catharina de Lange. (2018) Simple and robust intravital microscopy procedures in TIE2GFP mice. ESCDD 2018 ; 2018-04-11 - 2018-04-13.
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PosterSofias, Alexandros Marios; Hak, Sjoerd. (2018) Embracing the Stealth Mode: Composing cRGD-modified lipid based nanoparticles able to escape extensive phagocytosis. CRS 2018 ; 2018-07-22 - 2018-07-24.
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Faglig foredragSofias, Alexandros Marios; Ochando, Jordi; Flobak, Åsmund; Mulder, Willem J. M.; Hak, Sjoerd. (2018) Tumor targeting by cRGD-modified nanoparticles is dominated by immune cell hitchhiking. WMIC 2018 ; 2018-09-12 - 2018-09-15.
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PosterSofias, Alexandros Marios; Ochando, Jordi; Grendstad, Kristin; Flobak, Åsmund; Mulder, Willem J. M.; Hak, Sjoerd. (2018) Tumor angiogenesis targeting by cRGD-modified nanoparticles is dominated by neutrophil hitchhiking. ESCDD 2018 ; 2018-04-11 - 2018-04-13.
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PosterSofias, Alexandros Marios; Ochando, Jordi; Mulder, Willem J. M.; Hak, Sjoerd. (2018) Circulating phagocytes contribute to angiogenesis targeting by cRGD-conjugated nanoparticles. NanoDDS 2018 ; 2018-09-21 - 2018-09-23.
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Faglig foredragSofias, Alexandros Marios; Ochando, Jordi; Mulder, Willem J. M.; Hak, Sjoerd. (2018) Hitchhiking with immune cells: Dominant tumor targeting mechanism for cRGD-modified nanoparticles. TMII 2018 ; 2018-04-26.
2017
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Faglig foredragMolska, Alicja; Sofias, Alexandros Marios; Nyman, Axel Karl Gottfrid; Hak, Sjoerd; Widerøe, Marius. (2017) Melatonin treatment for hypoxic-ischemic brain injury. Lipid-based nanoparticles as a platform for drug delivery. The 5th National PhD Conference in Neuroscience . NRSN; Sommarøy. 2017-09-20 - 2017-09-22.
2016
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PosterHak, Sjoerd; Zhao, Yiming; Mulder, Willem J.M.; de Lange Davies, Catharina; Haraldseth, Olav. (2016) A fluorescence Resonance energy transfer method to study payload release kinetics from lipid-based nanoparticles. European Symposium on Controlled Drug Delivery ; 2016-04-13 - 2016-04-15.
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PosterMolska, Alicja; Hak, Sjoerd; Widerøe, Marius. (2016) Lipid-based nanoparticles as a platform for drug delivery - melatonin treatment of hypoxic-ischemic brain injury. The 8th National PhD Conference in Medical Imaging . Medlm and CIUS; Trondheim. 2016-11-21 - 2016-11-22.
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PosterSofias, Alexandros Marios; Widerøe, Marius; Davies, Catharina De Lange; Haraldseth, Olav; Hak, Sjoerd. (2016) Elucidating targeting kinetics towards integrins: A quantitative study. The 8th National PhD Conference in Medical Imaging - MedIm 2016 . Norwegian Research School in Medical Imaging; Trondheim. 2016-11-21 - 2016-11-22.
2015
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PosterHak, Sjoerd; Åslund, Andreas K. O.; Zhao, Yiming; Mulder, Willem J.M.; Haraldseth, Olav; Davies, Catharina De Lange. (2015) A fluorescence resonance energy transfer labeling method to study dissociation kinetics of lipid-based nanoparticles. World Molecular Imaging Conference ; 2015-09-02 - 2015-09-05.
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PosterMcDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm. (2015) L-DOPA-coated manganese oxide nanoparticles as dual MRI contrast agents and potential drug delivery vehicles. Nordic Neuroscience 2015 . Scandinavian Physiological Society; Trondheim. 2015-06-10 - 2015-06-12.
2014
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Vitenskapelig foredragHak, Sjoerd; Zuzana, Garaiova; Olsen, Linda Therese; Nilsen, Asbjørn Magne; Davies, Catharina De Lange. (2014) The Effects of Oil-in-water Nanoemulsion Polyethylene Glycol Surface Density on Intracellular Stability, Pharmacokinetics, and Biodistribution in Tumor Bearing Mice. World Molecular Imaging Conference . WMIS; Seoul. 2014-09-17 - 2014-09-20.
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PosterÅslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Sandvig, Axel; Torp, Sverre Helge; Stenstad, Per Martin; Hansen, Rune; Glomm, Wilhelm; Davies, Catharina De Lange. (2014) Delivery of multifunctional nanoparticles across the blood-brain barrier. The 2014 Joint National PhD Conference in Medical Imaging and MedViz Conference . Medim/medviz; Grand Terminus Hotel, Bergen, Norway. 2014-06-17 - 2014-06-18.
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Faglig foredragÅslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Stenstad, Per Martin; Hansen, Rune; Davies, Catharina De Lange. (2014) Multifunctional nanoparticles for drug delivery across the blood-brain barrier. Biofysikkmøtet 2014 ; Soria Moria, Holmenkollen. 2014-03-06 - 2014-03-07.
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Faglig foredragÅslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Widerøe, Marius; Sandvig, Axel; Stenstad, Per Martin; Hansen, Rune; Davies, Catharina De Lange. (2014) Nanoparticle-microbubbles and focused ultrasound to penetrate the blood-brain barrier. COST TD1004 Action: Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery . COST action TD1004; Kaya Ramada Hotel, Istanbul. 2014-10-03 - 2014-10-04.
2013
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Vitenskapelig foredragHak, Sjoerd. (2013) Targeted particles and polymers. World Molecular Imaging Conference . WMIS; Savannah. 2013-09-18 - 2013-09-21.
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Vitenskapelig foredragHak, Sjoerd; Cebulla, Jana; Huuse, Else Marie; Davies, Catharina De Lange; Mulder, Willem J.M.; Larsson, Henrik BW; Haraldseth, Olav. (2013) Tumor Targeting Kinetics of Ligand-Functionalized Nanoparticles Studied with Dynamic Contrast Enhanced Magnetic Resonance Imaging and Intravital Microscopy. World Molecular Imaging Conference . WMIS; Savannah. 2013-09-18 - 2013-09-21.
2011
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PosterHak, Sjoerd; Thuen, Marte; Jarzyna, Peter A.; Mulder, Willem J.M.; Syversen, Tore; Haraldseth, Olav; Davies, Catharina De Lange. (2011) Combined in vivo confocal laser scanning microscopy and magnetic resonance imaging to study an αvβ3-integrin targeted nanoemulsion. International Society for Magnetic Resonance in Medicine ; 2011-05-07.
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PosterHak, Sjoerd; Emily, Helgesen; Hektoen, Helga H; Sæterbø, Kristin Grenstad; Marte, Thuen; Mulder, Willem J. M.; Haraldseth, Olav; Davies, Catharina De Lange. (2011) Combined in vivo confocal laser scanning microscopy and magnetic resonance imaging to study an avb3-integrin targeted nanoemulsion. World Molecular Imaging Conference ; 2011-09-10.
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PosterHak, Sjoerd; Helgesen, Emily; Hektoen, Helga H; Sæterbø, Kristin Grendstad; Thuen, Marte; Mulder, Willem J. M.; Haraldseth, Olav; Davies, Catharina De Lange. (2011) The effect of polyethylene glycol surface density on the targeting efficiency of αvβ3-integrin specific nanoparticles. PhD conference Norwegian Research School in Medical Imaging ; 2011-11-20.
2010
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PosterHak, Sjoerd; Jarzyna, Peter A.; Mulder, Willem J.M.; Thuen, Marte; Reitan, Nina Kristine; Haraldseth, Olav; Davies, Catharina De Lange. (2010) Combined in vivo MRI and in vivo CLSM to study the behavior of multifunctional nanoemulsions. World Molecular Imaging Conference . Society for Molecular Imaging; Kyoto. 2010-09-07 - 2010-09-10.