Bakgrunn og aktiviteter
Has a master and PhD in organic chemistry from Linköping University, Sweden. Has been working as a post doc in Catharina Davies´s group since February 2013.
Born and raised in Øst Trøndelag (Härjedalen, Sweden) I moved south to Linköping to persue my academic studies. I obtained a Master in organic chemistry in 2003 and received a stipend to do som research for a year within the same field.
In 2004 I started my PhD and worked mainly on synthesizing flourescent dyes that were used to study protein aggregation related diseases, like Alzheimer´s disease and prion diseases. We were able to design a probe that could be used in vivo by i.v. injections and that was conformationally sensitive which meant that the flourescent spectra of the dye could act as fingerprint for a specific strain of aggregates or depending on how the had been fibirlized. In 2009 I defended my thesis named Designing thiophene-based fluorescent probes for the study of neurodegenerative protein aggregation diseases: From test tube to in vivo experiments.
In 2010 I started as a post doc in an EU framework 7 program called LUPAS that were utilizing the probes we previously developed but also developed new probes. Within in the project we looked at both treatment and diagnostics of primarily protein aggregation diseases. The project ended in 2012.
After almost fifteen years within organic chemistry, but also a lot of studies in vivo and in vitro models, I wanted to pursue this in vitro/in vivo aspect of research. And Catharina Davies and her group had a very interesting cross disciplinary project, with the focus on in vivo experiments but to some extent also in vitro experiments. Since February 2013 I am now working within this project. The project has a novel approach to open up the blood-brain barrier (BBB) and although many groups are doing parts of what we are trying to do, no one is combining it into one project, as we know of. We will use in house (SINTEF) synthesized gas filled microbubbles to open the BBB with focused ultrasound (FUS). The FUS will make the gas bubbles oscilate and burst in this will stress the BBB so that it opens up. Moreover, we will attempt to in advance down regulate the efflux pumps so that the drug containing nanoparticles that pass the BBB does not get pumped out in to circulation again, but stay within in the tumor. The microbubbles in them self are unique since the are composed of nanoparticles. And the nanoparticles can be loaded with a desired drug, dye or cell aiming possibilities.
The overall goal of this project is to establish a generic vessel that can transport a drug across the BBB.
Vitenskapelig, faglig og kunstnerisk arbeid
Et utvalg av nyere tidsskriftspublikasjoner, kunstneriske produksjoner, bok, inklusiv bokdeler og rapport-del. Se alle publikasjoner i databasen
- (2017) The effect of poly(ethylene glycol) coating and monomer type on poly(alkyl cyanoacrylate) nanoparticle interactions with lipid monolayers and cells. Colloids and Surfaces B: Biointerfaces. vol. 150.
- (2017) Primary Porcine Brain Endothelial Cells as In Vitro Model to Study Effects of Ultrasound and Microbubbles on Blood-Brain Barrier Function. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. vol. 64 (1).
- (2017) Quantification and Qualitative Effects of Different PEGylations on Poly(butyl cyanoacrylate) Nanoparticles. Molecular Pharmaceutics. vol. 14 (8).
- (2017) Efficient Enhancement of Blood–Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT). Theranostics. vol. 7 (1).
- (2016) Gelling kinetics and in situ mineralization of alginate hydrogels: A correlative spatiotemporal characterization toolbox. Acta Biomaterialia. vol. 44.
- (2016) Labeling nanoparticles: Dye leakage and altered cellular uptake. Cytometry Part A.
- (2016) Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles. Journal of Nanobiotechnology. vol. 14 (1).
- (2015) Structure-based drug design identifies polythiophenes as antiprion compounds. Science Translational Medicine. vol. 7 (299).
- (2015) An azide functionalized oligothiophene ligand - A versatile tool for multimodal detection of disease associated protein aggregates. Biosensors & bioelectronics. vol. 63.
- (2015) Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery. Contrast Media & Molecular Imaging. vol. 10 (5).
- (2015) Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles. Journal of Controlled Release. vol. 220.
- (2014) Contact-mediated intracellular delivery of hydrophobic drugs from polymeric nanoparticles. Cancer Nanotechnology. vol. 5 (1).