Studier av årsaker til medfødte misdannelser basert på Medisinsk fødselsregister
DOI:
https://doi.org/10.5324/nje.v17i2.148Abstract
Studier av årsaker til medfødte misdannelser har helt fra begynnelsen vært et viktig formål med Medisinsk fødselsregister (MFR). Det har sammenheng med at det var Thalidomidkatastrofen med epidemien av medfødte lemmedefekter tidlig på sekstitallet som førte til registerets opprettelse. Her gjennomgåes en rekke
studier basert på data fra MFR gjennom registerets førtiårige historie. Studiene spenner fra risiko knyttet til yrkesforhold, kraftlinjer og nedfall etter Tsjernobylkatastrofen til gjentagelsesmønstre innenfor familier. Oversikten vil ikke gi noe forsøk på endelig konklusjon knyttet til disse faktorene, fordi det ville forutsette en total gjennomgang av studier gjort også utenfor Norge. Oversikten dekker heller ikke alle studier med data fra MFR, men er ment å gi et hovedinntrykk av forskning som har benyttet MFR.
Identification of causes of birth defects has been a major purpose of The Norwegian Medical Birth Registry since the registry was started. This has dramatic background in the fact that it was the international epidemic of birth defects caused by the apparently harmless drug Thalidomide that lead to the establishment of the registry in 1967. A review of studies of causes of birth defects based on data from the registry through its 40 year long history is given here. The review spans a variety of studies from studies of occupational exposures, power lines and the Chernobyl fallout to studies of familial recurrence risks. The purpose is not to give a scientific review of current evidence of causal effects but to give an impression of the contribution of the registry to such research over the past 40 years
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