Evaluering av inflammatoriske mediatorer i diagnostikk av alvorlige neonatale infeksjoner
DOI:
https://doi.org/10.5324/nje.v7i1.361Abstract
Formål:
SAMMENDRAGStudie design:
Resultater:
IL-6 predikerte uavhengig infeksjon (
bidrag til infeksjonsdiagnosen. En kombinert parameter bestående av CRP
≥ 10 mg/l og/eller IL-6 > 50 pg/ml
ga en sensitivitet på 96% (95% CI: 88–100%), en spesifisitet på 74% (95% CI: 65–83%), en negativ prediktiv
verdi på 99% (95% CI: 96–100%) og en positiv prediktiv verdi på 49% (95% CI: 35–63%).
Konklusjon:
diagnosis of severe neonatal infections
Objective
ENGLISH SUMMARYStudy design
Results:
of IL-6 yielded independent contributions to the diagnosis of infection (
mediator made any further contribution to the diagnosis. A combined parameter of CRP
≥ 10 mg/l and/or IL-6 >
50 pg/ml yielded a sensitivity of 96% (95% CI: 88–100%), a specificity of 74% (95% CI: 65–83%), a negative
predictive value of 99% (95% CI: 96–100%) and a positive predictive value of 49% (95% CI: 35–63%).
Conclusion:
severe neonatal infections.
IL-6 in combination with CRP may constitute a valuable parameter in the early diagnosis ofp <0.05). The logaritm of CRP and the logaritmp < 0.001 resp. p = 0.03). No otherTwentyfour neonates with sepsis, clinical sepsis and pneumonia had significantly raised serum
levels of all six mediators compared to noninfected neonates (all
: Blood samples were collected at admittance from 165 neonates who were suspected to have a
severe bacterial infection and serum concentrations of the six inflammatory mediators were determined. We
analysed the mediators, either isolated or in combination, as diagnostic parameters by multiple logistic
regression, receiver-operator characteristic plots and predictive value theory (sensitivity and specificity).
: To study C-reactive protein (CRP), interleukin-6 (IL-6), soluble tumor necrosis factor receptors(TNFR) p55 and p75 and the adhesion molecules ICAM-1 and E-selectin in the early diagnosis of neonatal
sepsis.
The value of inflammatory mediators in the. Nor J Epidemiol 1997; 7 (1): 73-78.IL-6 i kombinasjon med CRP synes å være en verdifull parameter ved utredning av nyfødte
barn ved mistanke om alvorlig bakteriell infeksjon.
Døllner H, Johnsen H, Vatten L, Arntzen KJ, Austgulen R.
p < 0,05). Logaritmen til CRP og logaritmen til
p < 0,001, resp. p = 0,03). Ingen av de øvrige fire mediatorer ga ytterligere
Tjuefire barn med sepsis, klinisk sepsis og pneumoni hadde høyere serum konsentrasjon av alle
seks inflammatoriske mediatorer enn barn uten infeksjon (alle
Konsentrasjon av de inflammatoriske mediatorer ble bestemt i serum ved innleggelse hos 165
nyfødte barn med mistanke om alvorlig bakteriell infeksjon. Vi analyserte verdien av mediatorene enkeltvis
eller i kombinasjon til å predikere alvorlig neonatal infeksjon med multippel logistisk regresjon, receiveroperator
characteristic kurver og beregning av sensitivitet og spesifisitet.
Å studere C-reaktivt protein (CRP), interleukin-6 (IL-6), tumor nekrose faktor reseptor (TNFR) p55og p75 og adhesjonsmolekylene ICAM-1 og E-selectin som parametre for alvorlig bakteriell infeksjon hos
nyfødte barn.
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