TY - JOUR AU - Kvaavik, Elisabeth AU - Meyer, Haakon E. AU - Smedshaug, Guro Berge AU - Falch, Jan A. AU - Tverdal, Aage AU - Pedersen, Jan I. PY - 2009/11/05 Y2 - 2024/03/28 TI - Intervensjonsstudien "Forebyggelse av lårhalsbrudd". Metode og praktisk gjennomføring JF - Norsk Epidemiologi JA - Nor J Epidemiol VL - 10 IS - 1 SE - DO - 10.5324/nje.v10i1.518 UR - https://www.ntnu.no/ojs/index.php/norepid/article/view/518 SP - AB - <strong><span style="font-family: TimesNewRomanPS-BoldMT;"><span style="font-family: TimesNewRomanPS-BoldMT;"><p align="left"> </p><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left">Bakgrunn</p></span></span></em></strong></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left"> </p></span></em></strong></span><p align="left"> </p><p align="left"><span style="font-size: xx-small; font-family: TimesNewRomanPSMT;"><span style="font-size: xx-small; font-family: TimesNewRomanPSMT;">3 </span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">kan forebygge brudd blant sykehjemsbeboere. Her beskrives<p align="left">metoden og den praktiske gjennomføringen av studien.</p></span></span></p><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left">Metode</p></span></span></em></strong></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left"> </p></span></em></strong></span><p align="left"> </p><p align="left"><span style="font-size: x-small; font-family: Symbol;"><span style="font-size: x-small; font-family: Symbol;">m</span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">g vitamin D daglig som 5 ml tran og kontrollgruppa fikk 5 ml tran der vitamin D var fjernet. Endepunktene<p align="left">var lårhalsbrudd og alle ikke-vertebrale brudd. Et enkelt studieopplegg ble vektlagt. På bakgrunn</p><p align="left">av styrkeberegningen var målsetningen å inkludere ca. 2000 deltakere.</p></span></span></p><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left">Resultater</p></span></span></em></strong></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left"> </p></span></em></strong></span><p align="left"> </p><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left">Konklusjon</p></span></span></em></strong></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left"> </p></span></em></strong></span><p align="left"> </p><p align="left"><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">The intervention study<strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><p align="left">”Prevention of hip fractures”.</p></span></span></strong></span><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><p align="left"> </p></span></strong></span></strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-ItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-ItalicMT;">Nor J Epidemiol </span></span></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">2000; </span></span><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">10 </span></span></strong><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">(1): 79-85.</span></span></p><p align="left"> </p><strong><span style="font-family: TimesNewRomanPS-BoldMT;"><span style="font-family: TimesNewRomanPS-BoldMT;"><p align="left"> </p><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left">Background</p></span></span></em></strong></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left"> </p></span></em></strong></span><p align="left"> </p><p align="left"><span style="font-size: xx-small; font-family: TimesNewRomanPSMT;"><span style="font-size: xx-small; font-family: TimesNewRomanPSMT;">3 </span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">can prevent such<p align="left">fractures. Here we present the method and the implementation of the study.</p></span></span></p><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left">Method</p></span></span></em></strong></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left"> </p></span></em></strong></span><p align="left"> </p><p align="left"><span style="font-size: x-small; font-family: Symbol;"><span style="font-size: x-small; font-family: Symbol;">m</span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">g vitamin D daily in 5 ml cod liver oil for 2 years and the control group received 5 ml cod liver oil<p align="left">without vitamin D. The endpoints were hip fractures and all non-vertebral fractures. It was considered</p><p align="left">important to use a trial that the nursing homes would find easy to implement. According to power calculation</p><p align="left">the aim was to include about 2000 participants.</p></span></span></p><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left">Results</p></span></span></em></strong></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left"> </p></span></em></strong></span><p align="left"> </p><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left">Conclusion</p></span></span></em></strong></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><p align="left"> </p></span></em></strong></span><p align="left"> </p></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: The participation was lower than expected as recruiting nursing homes and nursing home<p align="left">residents posed considerable difficulty. However, the great majority of the ward staff at the participating</p><p>wards did not find the intervention demanding. A total of 1144 was included in the study.</p></span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: A total of 1144 residents from 51 nursing homes (of 106 invited) in Oslo, Lier and Bergen participated.<p align="left">The participation rate at the individual nursing home varied from 3 to 57%. The participants were</p><p align="left">85 years old and 3/4 were women. Mean calcium intake from cheese and milk was 450 mg/day, more than</p><p align="left">40% used a vitamin D supplement while only 3% used a calcium supplement. 1/3 of the participants completed</p><p align="left">the 2 years intervention, about 1/3 finished the intervention before 2 years because of death and 1/3</p><p align="left">finished before 2 years of other causes. The great majority of the wards did not find the intervention</p><p align="left">demanding.</p></span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: A randomised, double-blinded, controlled trial in nursing homes. The intervention group received<span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">10</p></span></span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left"> </p></span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: Vitamin D deficiency is a potential important risk factor for osteoporotic fractures. We have<span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">carried out a trial in nursing homes residents to study if supplementation with vitamin D</p></span></span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left"> </p></span></span></span></span><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">ENGLISH SUMMARY</span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: Deltakelsen var lavere enn forventet idet det var betydelige vansker med å rekruttere sykehjemsbeboere<p align="left">til studien, men de avdelinger som deltok fant gjennomføringen av studien lite arbeidskrevende.</p><p align="left">Totalt ble 1144 inkludert i studien.</p><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">Kvaavik E, Meyer HE, Smedshaug GB, Falch JA, Tverdal A, Pedersen JI.</p></span></span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left"> </p></span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: I alt 1144 beboere ved 51 sykehjem (av 106 forespurte) i Oslo, Lier og Bergen deltok. Deltakelsen<p align="left">ved de enkelte sykehjem varierte fra 3 til 57% av beboerne. Deltakerne var i gjennomsnitt 85 år og</p><p align="left">3/4 var kvinner. Kalsiuminntak fra ost og melk var i gjennomsnitt 450 mg/dag, 40% brukte vitamin Dtilskudd</p><p align="left">daglig mens 3% brukte kalsiumtilskudd. 1/3 av deltakerne fullførte intervensjonen, ca. 1/3 avsluttet</p><p align="left">før 2 år pga. død og 1/3 avsluttet før 2 år av andre årsaker. De fleste avdelingslederne fant det lite</p><p align="left">arbeidskrevende å gjennomføre intervensjonen.</p></span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: En randomisert, dobbelt blindet, kontrollert studie på sykehjem. Intervensjonsgruppa fikk i 2 år<span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">10</p></span></span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left"> </p></span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: Vitamin D-mangel er en potensielt viktig risikofaktor for osteoporotiske brudd. Vi har gjennomført<span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">en studie for å teste om vitamin D</p></span></span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left"> </p></span></span></span></span><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">SAMMENDRAG</span></span></strong> ER -