TY - JOUR AU - Nafstad, Per AU - Samuelsen, Sven O. AU - Irgens, Lorentz M. AU - Bjerkedal, Tor PY - 2009/10/13 Y2 - 2024/03/28 TI - Svangerskapskomplikasjoner og risikoen for astma blant nordmenn født 1967-1993 JF - Norsk Epidemiologi JA - Nor J Epidemiol VL - 15 IS - 1 SE - DO - 10.5324/nje.v15i1.226 UR - https://www.ntnu.no/ojs/index.php/norepid/article/view/226 SP - AB - <strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left">Bakgrunn</p></font></font></em></strong></span><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left"> </p></font></em></strong></span><p align="left"> </p><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left">Metode</p></font></font></em></strong></span><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left"> </p></font></em></strong></span><p align="left"> </p><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left">Resultater</p></font></font></em></strong></span><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left"> </p></font></em></strong></span><p align="left"> </p><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left">Konklusjon</p></font></font></em></strong></span><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left"> </p></font></em></strong></span><p align="left"> </p><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left">Background</p></font></font></em></strong></span><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left"> </p></font></em></strong></span><p align="left"> </p><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: Fetal life events may affect the development of the immune and/or respiratory system and increase the risk of asthma and allergic diseases. The objective of this study was to test the hypothesis that pregnancy complications are associated with the risk of developing asthma in the offspring.</span></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left">Methods</p></font></font></em></strong></span><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left"> </p></font></em></strong></span><p align="left"> </p><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: The study population comprised Norwegian live births 1967-1993 (n = 1 548 429) linking the Medical Birth Registry of Norway (MBRN) (exposure variables) and the National Insurance Administration Register (NIAR) (outcome variables), which covers all Norwegians. The MBRN variables included pregnancy complications, pregnancy outcomes and diseases of the mother. The NIAR provided data on all Norwegians who had received cash benefit for treatment of asthma from 1967 to 1996 (n = 5938, 3.9/1000 persons).</span></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left">Results</p></font></font></em></strong></span><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left"> </p></font></em></strong></span><p align="left"> </p><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: In multiple logistic regression analysis, pregnancy complications (International Classification of Diseases (ICD)-8 codes: 630-34) were associated with the risk of asthma (odds ratio 1.82, 95% confidence interval: 1.67–1.98). This was also the case if analyses were performed in different strata according to year of birth, plurality, maternal atopy, geographical district of birth, and maternal education.</span></span><strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldItalicMT;"><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left">Conclusions</p></font></font></em></strong></span><strong><em><font face="TimesNewRomanPS-BoldItalicMT" size="2"><p align="left"> </p></font></em></strong></span><p align="left"> </p><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: Pregnancy complications may represent risk factors for the development of asthma in the offspring or express early signs of increased risk for developing the disease.</span></span></em></strong></em></strong></em></strong></em></strong></span></span></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: Svangerskapskomplikasjoner hos mor kan gi økt risiko for utvikling av astma hos barnet eller utrykke tidlige tegn på økt risiko for å utvikle sykdommen</span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: Multipell logistisk regresjonsanalyse viste at svangerskapskomplikasjoner (International Classification of Diseases (ICD)-8 kode 630-34) var assosiert med risikoen for å ha fått grunn- og/eller hjelpestønad for astma (odds ratio 1,82, 95% konfidensintervall: 1,67–1,98). Dette var også tilfelle hvis analysene ble utført i forskjellige strata av fødselsår, pluralitet, atopisk sykdom hos mor, utdanningsnivå hos mor og hvor i landet fødselen fant sted.</span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: Undersøkelsespopulasjonen består av levende fødte nordmenn født i perioden 1967-1993(n = 1 548 429). Opplysninger fra Medisinsk fødselsregister (MFR) ble koblet med opplysninger fra Rikstrygdeverket om mottatt grunn- og hjelpestønad. Fødselsregisteret inneholder opplysninger om svangerskapskomplikasjoner og sykdommer hos den gravide/fødende mor og Rikstrygdeverkets register inneholder opplysninger og diagnoser over alle nordmenn som har motatt grunn- og hjelpestønad pga. astma i perioden 1967-1996 (n = 5938, 3,9/1000 personer).</span></span></strong></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">: Det er mulig at forhold og hendelser i svangerskapet kan påvirke utviklingen av immunog/eller respirasjonssystemet og dermed øke risikoen for å utvikle astma og allergiske lidelser. I denne artikkelen testes hypotesen om hvorvidt svangerskapskomplikasjoner påvirker risikoen for at barn utvikler astma.</span></span></strong> ER -