EnvA-pseudotyped G-deleted Rabies viruses

kr 7150,00

Rabies virus is an enveloped, negative sRNA virus. Genetically modified rabies glycoprotein (G)-deleted rabies virus, trans-complemented with rabies-G (provided by transgenics or a helper virus) is used for transsynaptic input tracing. EnvA-pseudotyped recombinant rabies cannot infect mammalian cells but it will infect only the cells that express exogenous receptor TVA on it surface (starter cells). Subsequent application of EnvA pseudotyped glycoprotein (G)-deleted rabies virus will infect the TVA+ cells and due to the presence of trans complemented rabies-G, the infectious rabies virus are formed in starter cells which will result in monosynaptic spreading of G-deleted rabies viruses to directly connected, presynaptic neurons.

Currently we offer stock EnvA-pseudotyped G-deleted Rabies viruses. Vector core can assist in research by designing novel constructs and subsequent production of the viruses, please consult the core facility for the details.

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Weight 100 kg