Avneesh Jain
Forskning
HYPE : Cortical hyperexcitability in Chronic Migraine
This study is aimed to enhance our understanding of cortical hyperexcitability in Chronic Migraine (with and without aura) and to provide metrics (primarily the T2 of Glu) for developing targeted therapeutic interventions.
Dynamic MRS : REPRO
The aim of this study is to set up a multi Echo time (TE) experiment, in order to provide a reliable and robust measurement of the T2 relaxation of metabolites, with a specific interest for the T2 of Glutamate for detecting neurotransmission impairments.
Implementation of advanced 7T MR methods in personalization of the treatment of brain disorders
This project was aimed to develop a research platform for advanced in vivo magnetic resonance spectroscopy (MRS) methods at NTNU and St Olav university hospital.
Aging & Resilience Study
To unravel neurobiological mechanisms underlying emotional responses to
ultimately design effective interventions that help prevention and treatment of psychiatric symptoms, such as depression and anxiety, across ageing. (Previous work)
Publikasjoner
Altered hypothalamic metabolism in chronic cluster headaches patients measured with 1H-MRS at ultra-high magnetic field
The first 7T study to characterize hypothalamic metabolism in chronic cluster headache. We observed reductions in two crucial metabolites indicating hypothalamic neuronal involvement, possibly reflecting mitochondrial and energetic dysfunction.
Resilience-related neural similarity during naturalistic movie watching Open Access
This 7T based fMRI study sheds light on the mechanisms of resilience, highlighting that it involves a constellation of neuropsychological processes crucial for adapting to external stimuli.
Formidling
Scientific Lecture : European Headache Congress, Lisbon, 2025
Evidence of mitochondrial dysfunction and disrupted neuronal energy metabolism in hypothalamic neurons in Chronic Cluster Headache: A 7-Tesla ¹H MR Spectroscopy Study.
Migrene i et livsløpsperspektiv, Hodepineaften, Trondheim, 2025
Presenterer vår nye forskningsstudie om Kronisk Migrene og hypereksitabilitet ved bruk av 7T 1H-MRS
Proffered Abstract : Center for Magnetic Resonance Research, Minneapolis, Minnesota, 2025
Towards reliable Glutamate T2 quantification at 7T: Role of macromolecules and model choice.
To investigate the Influence of macromolecular background on the evaluation of glutamate (Glu) transverse relaxation time (T₂).
Lecture : European Headache Congress, Rotterdam 2024
Studying the metabolic profile of chronic cluster headache (cCH) in pain perception-related
areas could provide novel, useful clinical information
Scientific talk : European Society for Magnetic Resonance in Medicine, Barcelona, 2024.
Higher thalamic myo-Inositol measured at 7T suggests novel mechanisms
in chronic cluster headaches.
2025
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Konferanseforedrag(2025) Towards reliable Glutamate T2 quantification at 7T: Role of macromolecules and model choice. 15th Biennial Workshop on Ultra-High Field Imaging
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Konferanseforedrag(2025) Evidence of mitochondrial dysfunction in hypothalamic neurons in chronic cluster headache: A 7T ¹H MR spectroscopy study. 19th European Headache Congress - EHC2025 - Lisbon
2024
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Konferanseposter(2024) Higher thalamic myo-Inositol measured at 7T using 1H-MR spectroscopy suggests novel mechanisms in chronic cluster headaches. 18th European Headache Concgress
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Konferanseforedrag(2024) Higher thalamic myo-Inositol measured at 7Tesla suggests novel mechanisms in chronic cluster headaches. European Society for Magnetic Resonance in Medicine and Biology 40th Annual Scientific Meeting