Folsyre og medfødte misdannelser
DOI:
https://doi.org/10.5324/nje.v7i1.349Abstract
SAMMENDRAG
Folsyre, et B vitamin, er viktig for en normal utvikling av fosterets nervesystem. En rekke intervensjonsstudier
har vist at forekomsten av nevralrørsdefekter og misdannelser i hjerne/ryggmarg, kan reduseres
med opptil 70% dersom mor får folsyretilskudd (0,4 / 4,0 mg) fra minst en måned før befruktning til og
med tredje svangerskapsmåned. Perikonsepsjonell bruk av multivitaminer er også assosiert med reduksjon
av andre medfødte misdannelser som leppe-/ganespalte, urinveis- og hjertemisdannelser og manglende
eller misdannede lemmer hos fosteret.
Bjørke Monsen A-L.
Folic acid and fetal malformations. Nor J Epidemiol 1997; 7 (1): 19-22.
ENGLISH SUMMARY
Folic acid, a B vitamin, is essential for normal development of the central nervous system during the early
weeks of gestation. Both observational and intervention studies have demonstrated that periconceptional
administration of folate (0.4 / 4.0 mg) reduces the occurence and the recurrence rate of neural tube defects.
Periconceptional multivitamin supplementation has also been associated with reduction of other congenital
malformations like cleft lip/palate, urinary tract defects, cardiovascular defects and limb reductions.
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