The Autism Birth Cohort (ABC):a study of autism spectrum disorders in MoBa

Authors

  • Pål Surén
  • Synnve Schjølberg
  • Anne-Siri Øyen
  • Kari Kveim Lie
  • Mady Hornig
  • Michaeline Bresnahan
  • Therese Bakke
  • Christine Roth
  • Elin Alsaker
  • Patricia Schreuder
  • Nina Stenberg
  • Ted Reichborn-Kjennerud
  • Deborah Hirtz
  • Ezra Susser
  • Per Magnus
  • Ian Lipkind
  • Camilla Stoltenberg

DOI:

https://doi.org/10.5324/nje.v24i1-2.1757

Abstract

Background: Autism spectrum disorders (ASDs) are characterized by persistent deficits in social communication and interaction and restricted, repetitive patterns of behavior, interests or activities. In most cases, the cause of ASD is likely to be a combination of genetic predisposition and environmental exposures occurring in fetal life or early infancy. Consequently, a prospective pregnancy cohort like MoBa represents an ideal platform for studies of ASDs in children.

Methods: The Autism Birth Cohort (ABC) Study has identified potential ASD cases in MoBa through questionnaire- based screening, parental and professional referrals, and linkages to the Norwegian Patient Register. ASD diagnoses have been ascertained through in-person clinical assessments and medical record reviews.

Current results: By the end of 2012, the ABC Study had identified 518 ASD cases in MoBa. The ASD prevalence in school-age children is 0.7-0.8%, which is in line with nationwide estimates for Norway. The most important source of ASD case identification was registry linkages, while only a minority was detected through early screening. Published findings show that screening at 18 months misses the majority of ASD cases. Analyses of risk factors for ASDs have shown that maternal use of folic acid supplements in early pregnancy may lower the child’s risk of developing ASDs and that paternal obesity appears to increase the child’s risk of ASDs.

Future plans: ASD case identification will continue through annual registry linkages and subsequent reviews of medical records. Analyses of plasma samples and RNA samples will be conducted to investigate prenatal and perinatal microbial exposures, innate immune and inflammatory responses, biomarkers of autism risk, and exposures to xenobiotics. Analyses of deciduous teeth will also investigate the effect of medications and environmental toxins. Exome sequencing of DNA from ASD cases and their parents is ongoing, and will elucidate the role of de novo DNA mutations in the pathogenesis of ASDs. Future epidemiological analyses will explore the results of the 36-month screening for ASDs, the diagnostic stability and developmental trajectories in ASD children, and psychiatric and medical comorbidities in ASDs.

Downloads

Download data is not yet available.

Author Biographies

Pål Surén

Synnve Schjølberg

Anne-Siri Øyen

Kari Kveim Lie

Mady Hornig

Michaeline Bresnahan

Therese Bakke

Christine Roth

Elin Alsaker

Patricia Schreuder

Nina Stenberg

Ted Reichborn-Kjennerud

Deborah Hirtz

Ezra Susser

Per Magnus

Ian Lipkind

Camilla Stoltenberg

Downloads

Published

2014-12-22

How to Cite

Surén, P., Schjølberg, S., Øyen, A.-S., Lie, K. K., Hornig, M., Bresnahan, M., Bakke, T., Roth, C., Alsaker, E., Schreuder, P., Stenberg, N., Reichborn-Kjennerud, T., Hirtz, D., Susser, E., Magnus, P., Lipkind, I., & Stoltenberg, C. (2014). The Autism Birth Cohort (ABC):a study of autism spectrum disorders in MoBa. Norsk Epidemiologi, 24(1-2). https://doi.org/10.5324/nje.v24i1-2.1757