Inflammation and Toll group
The general strategy of our research is to study the functions of Toll-like receptors (TLRs) in relation to inflammatory responses. In particular, we are addressing involvement of inflammatory responses in host defence against microbes and cancer. We have a focus on characterizing mechanisms behind cellular trafficking of TLRs in relation to their functions. The group has a long track record and has made several significant contributions within TLRs and inflammation and we were among the first to demonstrate the lethal effects of tumour necrosis factor in gram negative septic shock. The group consists of approximately 25 persons. Specifically, we are working on the following projects:
- Trafficking of Toll-like receptors and its contribution to innate immunity
- Pathogenomics of bacteria studied by systems biology; a new approach to discover TLR immune evasion and activation mechanisms
- Regulation of CMV infections in fibroblasts
- The mycobacterial phagosome maturation arrest: allowing iron acquisition while maintaining immune evasion
- Regulation of B cell differentiation and functions: involvement of TLRs and bone morphogenetic proteins (BMPs)
- Characterization and modulation of inflammatory responses in chronic wounds
- Mechanisms behind particle induced allergy and inflammation
- Development of alginate biopolymers for immunomodulation and cell encapsulation
