SPACEBRAIN at the University of Heidelberg
Hannah Monyer is the Head of the Department for Clinical Neurobiology. Her research is interdisciplinary and the approaches in the lab resort to molecular (generation of genetically modified mice), electrophysiological (patch-clamp recordings in the acute slice), and anatomical (cell reconstruction, immunohistochemistry) techniques. Over the last two years in vivo recording (using tetrodes and silicon probes) in freely moving wildtype and mutant mice has been established in the lab.
Hannah Monyer leads a scientific team with both molecular biologists and electrophysiologists. The former team consists of 7 postdocs and 3 PhD students. In vitro electrophysiological studies are carried out by 3 postdocs and measurements in vivo are performed by 2 postdocs and 1 PhD student. The Department is financed in part by the Schilling Foundation and the Medical Faculty. Additional positions are financed by German or other research grants. The genetically altered mice are generated in the animal facility of the University. The current mouse space assigned to the lab is 2000 animals.
In the SPACEBRAIN project, Hannah Monyer will work on the anatomical and functional characterization of distinct GABAergic interneurones in the entorhinal cortex making use of transgenic mice. She will use mouse mutants with ‘floxed’ receptors that will enable them to generate region-specific knockout mice (via viral delivery into hippocampus or entorhinal cortex) to study functional and behavioural modifications.
Bilde av Hannah Monyer