Mirta Mittelstedt Leal Sousa

Research interests:

• Proteomics
• DNA Repair

Education:

PhD in Molecular Medicine, 2012.
Department of Cancer Research and Molecular Medicine, NTNU, Norway.

MSc in Molecular Biology, 2003.
Department of Cellular Biology Brasília, University of Brasília, Brazil.

BSc in Chemistry, 2000.
Department of Chemistry Brasília, University of Brasília, Brazil.

List of publications:

9. Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to-noise ratio in downstream 2D-PAGE analysis. Sousa, M.M.L., Steen, K.W., Hagen, L., Slupphaug, G. Proteome Science, 9(1): 45 (2011)

8. Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Baglo, Y., Sousa, M.M.L., Slupphaug, G., Hagen, L., Håvåg, S., Helander, L., Zub, K.A., Krokan, H., Gederaas, O.A. Photochemical and Photobiological Sciences, 10:1137-1145 (2011)

7. Divergent β-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3. Monsen, V.T., Sundheim, O., Aas, P.A., Westbyen, M.P., Sousa, M.M.L., Slupphaug, G., Krokan, H.E. Nucleic Acids Research 38(19): 6447-6455 (2010).

6. Identification of a novel, widespread, and functionally important PCNA-binding motif. Gilljam, K.M., Feyzi, E., Aas, P.A., Sousa, M.M.L., Müller, R., Vågbø, C.V., Catterall, T.C., Liabakk, N.B., Slupphaug, G., Drabløs, F., Krokan, H.E., Otterlei, M. The Journal of Cell Biology, 186(5):645–654 (2009).

5. Uracil in DNA and its processing by different DNA glycosylases. Visnes,T., Doseth, B., Pettersen, H.S., Hagen, L., Sousa, M.M.L., Akbari, M., Otterlei, M., Kavli, B., Slupphaug, G. and Krokan, H.E.. Phil. Trans. R. Soc. B 364, 563-568 (2009).

4. Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. Hagen, L., Kavli, B.M., Sousa, M.M.L., Torseth, K., Liabakk, N., Sundheim, O., Diaz, J.P., Otterlei, M., Hørning, O., Jensen, O.N., Krokan, H.E., Slupphaug, G. The EMBO Journal 27:51–61 (2008).

3. DNA-uracil and human pathology. Sousa, M.M.L., Krokan, H.E., Slupphaug, G.Molecular Aspects of Medicine 28:276–306 (2007).

2. Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Sundheim, O., Vågbø, C.B., Bjørås, M., Sousa, M.M.L., Talstad, V., Aas, P.A., Drabløs, F., Krokan, H.E., Tainer, J.A., Slupphaug, G. The EMBO journal, 25(14): 3389–3397 (2006).

1. Sequence similarity-based proteomics in insects: characterization of the larvae venom of the brazilian moth Cerodirphia speciosa. Shevchenko, A., Sousa, M.M.L., Waridel, P., Bittencourt, S.T., Sousa, M.V., and Shevchenko, A. Journal of Proteome Research 4, 862-869 (2005).