Mirta Mittelstedt Leal de Sousa
Om
Research interests:
- Proteomics
- Neuroscience
- Biochemistry
- DNA Repair
- Cancer research
Formal Education:
PhD in Molecular Medicine, 2012.
Department of Cancer Research and Molecular Medicine, NTNU, Norway.
MSc in Molecular Biology, 2003.
Department of Cellular Biology Brasília, University of Brasília, Brazil.
BSc in Chemistry, 2000.
Department of Chemistry Brasília, University of Brasília, Brazil.
Postdoctoral Institutions
2012-2020.
Department of Cancer Research and Molecular Medicine, NTNU, Norway.
2012-2013.
Lawrence Berkeley National Laboratory (LBNL), Berkeley, California, USA.
The Joint Bioenergy Institute (JBEI), Emeryville, California, USA.
List of publications:
39. Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells. Neurauter, C.G., Pannone, M., Sousa, M.M.L., Wang, W., Kuśnierczyk, A. Luna, L., Sætrom, P., Scheffler, K., Bjørås, M. Free Radical Biology and Medicine. 2024 213:470-487. DOI: 10.1016/j.freeradbiomed.2024.01.037
38. NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA. Starheim, E.J., Ravlo, E., Schølberg, J., Solvang, V., Wang, W., Scrimgeour, N.R., Manaf, A., Erlandsen, S.E., Aas, P.A., Hagen, L., Sousa M.M.L., Bjørås. Sci Rep. 2023 Nov 27;13(1):20836. DOI: 10.1038/s41598-023-46868-5
37. Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation iin early brain development. Lin, X., Wang, W., Yang, M., Damseh, N., Sousa M.M.L., Jacob, F., Lang, A., Kristiansed, E., Pannone, M., Kissova, M., Almaas, R., Kusnierczyk, A., Siller, R., Shahrour, M., Al.Asjjab, M., Abu-Libdeh, B., Tang, W., Slupphaug, G., Elpeleg, O., Boe, S.O., Eide, L., Sullivan, G.J., Rinholm, J.E., Song, H., Ming, G., Loon, B.V., Edvardson, S., Ye, J., Bjørås. Genome Biology. 2023, 24: 216 DOI: https://doi.org/10.1186/s13059-023-03037-1.
36. A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles. Ravlo, E., Sousa M.M.L., Andersen, L.L., Holberg-Petersen, M., Klundby, I., Aas, P.A., Hagen, L.., Erlandensen, S.E., Malmring, J.F., Ali, Z., Sharma, A., Ottesen, V., Bandyopadhyay, S., Bjørås M. Scientific Reports. 2023, 13, 11714. DOI:https://doi.org/10.1038/s41598-023-38743-0
35. Severely-ill COVID-19 patients have altered circulating levels of proteins controlling the epitranscriptome. Quiles-jiménez A., Sousa M.M.L., Huse C., Dyrhol-Riise A.M., Holter, J.C., Christensen E.E., Tonby K., Holten A.R., Aukrust P., Bjørås M., Dahl T.B., Halvorsen B. Journal of Infection. 2023. Letter to the Editor. DOI:https://doi.org/10.1016/j.jinf.2023.03.002
34. DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients. Olsen M.B., Huse C., Sousa M.M.L., Murphy S.L., Sarno A., Obermann T.S., Yang K., Holter J.C., Jørgensen M.J., Christensen E.E., Wang W., Ji P., Heggelund L., Hoel H., Dyrhol-Riise A.M., Gregersen I., Aukrust P., Bjørås M., Halvorsen B., Dahl T.B. Journal of Inflammation Research. 2022, 15:6629-6644. DOI: 10.2147/JIR.S379331. eCollection 2022.
33. Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses. Kaarbø M., Yang, M., Hov, J.R., Scient, K.H.C., Sousa M.M.L., Macpherson, M.E., Reims, H.M., Kran, A.M., Halvorsen, B., Karlsen T.H., Aukrust, P., Lundin, K.E.A., Fevang, B., Bjørås M., Jørgensen, S.F. Journal of allergy and clinical immunology 2022. S0091-6749(22)01335-5. DOI:10.1016/j.jaci.2022.09.029. DOI: https://doi.org/10.1016/j.jaci.2022.09.029
32. Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant. Maddirevula S., Alameer S., Ewida, N., Sousa M.M.L., Bjørås M., Vågbø C.B., Alkuraya, F.S. Human genetics 2021, 141:209-215. DOI: 10.1007/s00439-021-02391-z.
31. Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction. Sousa M.M.L., Ye J., Luna L., Hildresstrand G., Bjørås K., Scheffler K., Bjørås M. International Journal of Molecular Sciences. 2021, 22:12024. doi: https://doi.org/10.3390/ijms222312924.
30. N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis.Quiles-Jiménez A.Gregersen I., Sousa M.M.L., Abbas A., Kong X.Y., Alseth I, Holm S,Dahl TB,Skagen K., Skjellan M., Aukrust P., Bjørås M., Halvorsen B. Biochemical and Biophysical Research Communications. 2020, 533(4):631-637.
29. HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines. Iveland T.S., Hagen L., Sharma A., Sousa M.M.L., Sarno A., Wollen K.L., Liabakk N.B., Slupphaug G. J Transl Med. 2020 Apr 7;18(1):159. doi: 10.1186/s12967-020-02318-8.
28. OXR1A, a coactivator of PRMT5 regulating Histone Arginine Methylation. Yang M., Lin X., Segers F., Suganthan R., Hildrestrand G.A., Rinholm J.E., Aas P.A., Sousa M.M.L., Holm S., Bolstad N., Warren D., Berge R.K., Johansen R.F., Yndestad A., Kristiansen E., Klungland A., Luna L., Eide L., Halvorsen B., Aukrust P., Bjørås M. Cell Rep. 2020 Mar 24;30(12):4165-4178.e7. doi: 10.1016/j.celrep.2020.02.063.
27. Separating Golgi proteins from cis to trans reveals underlying properties of cisternal localization. Parsons H.T., Stevens T.J., McFarlane H.E., Vidal-Melgosa S., Griss J., Lawrence N., Butler R., Sousa M.M.L., Salemi M., Willats W.G.T., Petzold C.J., Heazlewood J.L., Lilley K.S. The Plant Cell, 2019. July. DOI: https://doi.org/10.1105/tpc.19.00081
26. Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil. Sarno A., Lundbæk M., Liabakk N., Aas P.A., Mjelle R., Hagen L., Sousa M.M.L., Krokan H.E., Kavli B. Nucleic acids research, 2019. Mar 6, pii: gkz145. DOI: 10.1093/nar/gkz145.
24. p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage. Sousa M.M.L., Bjørås K.Ø., Hanssen-Bauer, A., Solvang-Garten, K., Otterlei M. Nature Scientific Reports. Jul 24;7(1):6322 (2017). DOI: 10.1038/s41598-017-06770-3.
23. Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication. Bjørås K.Ø., Sousa M.M.L., Sharma A., Fonseca D.M., Søgaard C.K., Bjørås M., Otterlei M. Nucleic Acids Research. Aug 21;45(14):8291-8301 (2017). DOI: 10.1093/nar/gkx476.
22. Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia. Zatula A., Dikic A., Mulder C., Sharma A., Vågbø C.B., Sousa M.M.L., Waage A., Slupphaug G. Oncotarget. 8(12):19427-19442 (2017). DOI: 10.18632/oncotarget.14294.
21. Novel UCHL1 mutations reveal new insights into ubiquitin processing. Rydning S.L., Backe P.H., Sousa M.M.L., Iqbal Z., Øye A.M., Sheng Y., Yang M., Lin X., Slupphaug G., Nordenmark T.H., Vigeland M.D., Bjørås M., Tallaksen C.M., Selmer K.K. Hum Mol Genet. 26 (6): 1031-1040 (2017). DOI: 10.1093/hmg/ddw391.
20. Analysis of the biotechnological potential of a Lentinus crinitus isolate in the light of its secretome. Cambri G., Sousa M.M.L., Fonseca D.M., Marchini F., Silveira J.L.M., Paba J. Journal of Proteome Research 15(12):4557-4568 (2016). DOI: 10.1021/acs.jproteome.6b00636.
19. Genomic uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. Krokan, H.E., Slupphaug, G. Sætrom, P., Sarno, A., Galashevskaya, A., Lundbæk, M.B., Aas, P.A., Krokan, R.H., Liabakk, N.B., Pettersen, H.S., Sousa M.M.L., Doseth, B., Kavli, B. Toxicology Letters 258(16):S19 (2016). DOI: https://doi.org/10.1016/j.toxlet.2016.06.1182.
18. Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA. Skarpegland T., Dahl T.B., Skjelland M., Scheffler K., Sousa M.M.L., Gregersen I., Kusnierczyk A., Sharma A., Slupphaug G., Eide L., Segers F.M., Skagen K.R., Dahl C.P., Russell D., Folkersen L., Krohg-Sørensen K., Holm S., Bjørås M., Aukrust P., Halvorsen B. Free Radic Biol Med. 97:386-397 (2016). DOI: http://doi.org/10.1016/j.freeradbiomed.2016.07.001.
17. Aerobic interval training reduces inducible ventricular arrhytmias in diabetic mice after myocardial infarction. Rolim N.P., Skårdal K., Høydal M., Sousa M.M.L., Malmo V., Kaurstad G., Ingul C.B., Hansen H.E., Alves M.N., Thuen M., Haraldseth O., Brum P.C., Slupphaug G., Loennechen J.P., Stølen T., Wisløff U. Basic Res Cardiol 110(4):44 (2015). DOI:10.1007/s00395-015-0502-9.
16. Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells. Zub K.A., Sousa M.M.L., Sarno A., Sharma A., Demirovic A., Rao S., Young C., Aas P.A., Ericsson I., Sundan A., Jensen O.N., Slupphaug G. PlosOne. Mar 13;10(3):e0119857 (2015). DOI: 10.1371/journal.pone.0119857.
15. AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. Pettersen, H.S., Galashevskaya, A., Doseth, B., Sousa, M.M.L., Sarno, A., Visnes, T., Aas, P.A., Liabakk, N.B., Slupphaug, G., Sætrom, P., Kavli, B.M., Krokan, H.E. DNA repair. 25:60-71 (2015). DOI:10.1016/j.dnarep.2014.11.006.
14. A kinetic-based approach to understanding heterologous mevalonate pathway function in E. coli. Weaver, L.J., Sousa, M.M.L., Wang, G., Baidoo, E., Petzold, C.J., Keasling, J.D. Biotechnology and Bioengeneering. 112(1):111-9 (2015). DOI: 10.1002/bit.25323.
13. A targeted proteomics toolkit for high-throughput absolute quantification of Escherichia coli proteins. Batth, T.S., Singh, P., Ramakrishnan, V.R., Sousa, M.M.L., Chan, L.J.G., Tran, H.M. Luning, E.G., Pan, E.H.Y., Vuu, K.M., Keasling, J.D., Adams, P.D., Petzold, C.J. Metabolic Engeneering. 26C:48-56 (2014). DOI: 10.1016/j.ymben.2014.08.004.
12. Atrial myocyte function and Ca2+ handling is associated with inborn aerobic capacity. Johnsen, A.B., Rolim, N.P.L., Stølen, T., Alves, M., Sousa, M.M.L., Slupphaug, G., Britton, S.L., Koch, L.G., Smith, G.L., Wisløff, U., Høydal, M.A. Plos One. 8(10):e76568 (2013).
11. An inverse switch in DNA base excision and strand break repair contributes to Melphalan resistance in multiple myeloma cells. Sousa, M.M.L., Zub, K.A., Aas, P.A., Hanssen-Bauer, A., Demirovic, A., Sarno, A., Tian, E., Liabakk, N.B., Slupphaug, G. Plos One. 8(2):e55493 (2013).
10. Eating behavior and glucagon-like peptide-1 producing cells in interposed ileum and pancreatic islets in rats subjected to ileal interposition associated with sleeve gastrectomy. Johannessen, H., Kodama, Y., Zhao, C., Sousa, M.M.L, Slupphaug, G., Kulseng, B.E., Chen, D. Obesity Surgery. 23(1):39-49 (2013).
9. Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to-noise ratio in downstream 2D-PAGE analysis. Sousa, M.M.L., Steen, K.W., Hagen, L., Slupphaug, G. Proteome Science, 9(1): 45 (2011)
8. Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Baglo, Y., Sousa, M.M.L., Slupphaug, G., Hagen, L., Håvåg, S., Helander, L., Zub, K.A., Krokan, H., Gederaas, O.A. Photochemical and Photobiological Sciences, 10:1137-1145 (2011)
7. Divergent β-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3. Monsen, V.T., Sundheim, O., Aas, P.A., Westbyen, M.P., Sousa, M.M.L., Slupphaug, G., Krokan, H.E. Nucleic Acids Research 38(19): 6447-6455 (2010).
6. Identification of a novel, widespread, and functionally important PCNA-binding motif. Gilljam, K.M., Feyzi, E., Aas, P.A., Sousa, M.M.L., Müller, R., Vågbø, C.V., Catterall, T.C., Liabakk, N.B., Slupphaug, G., Drabløs, F., Krokan, H.E., Otterlei, M. The Journal of Cell Biology, 186(5):645–654 (2009).
5. Uracil in DNA and its processing by different DNA glycosylases. Visnes,T., Doseth, B., Pettersen, H.S., Hagen, L., Sousa, M.M.L., Akbari, M., Otterlei, M., Kavli, B., Slupphaug, G. and Krokan, H.E.. Phil. Trans. R. Soc. B 364, 563-568 (2009).
4. Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. Hagen, L., Kavli, B.M., Sousa, M.M.L., Torseth, K., Liabakk, N., Sundheim, O., Diaz, J.P., Otterlei, M., Hørning, O., Jensen, O.N., Krokan, H.E., Slupphaug, G. The EMBO Journal 27:51–61 (2008).
3. DNA-uracil and human pathology. Sousa, M.M.L., Krokan, H.E., Slupphaug, G.Molecular Aspects of Medicine 28:276–306 (2007).
2. Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Sundheim, O., Vågbø, C.B., Bjørås, M., Sousa, M.M.L., Talstad, V., Aas, P.A., Drabløs, F., Krokan, H.E., Tainer, J.A., Slupphaug, G. The EMBO journal, 25(14): 3389–3397 (2006).
1. Sequence similarity-based proteomics in insects: characterization of the larvae venom of the brazilian moth Cerodirphia speciosa. Shevchenko, A., Sousa, M.M.L., Waridel, P., Bittencourt, S.T., Sousa, M.V., and Shevchenko, A. Journal of Proteome Research 4, 862-869 (2005).
Publikasjoner
2024
-
Neurauter, Christine Gran;
Pannone, Marco;
Sousa, Mirta;
Wang, Wei;
Kusnierczyk, Anna;
Luna, Luisa.
(2024)
Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells.
Free Radical Biology & Medicine
Vitenskapelig artikkel
2023
-
Quiles-Jiménez, Ana M T;
Sousa, Mirta;
Huse, Camilla;
Dyrhol-Riise, Anne Ma;
Holter, Jan Cato;
Christensen, Erik Egeland.
(2023)
Severely ill COVID-19 patients have altered circulating levels of proteins controlling the epitranscriptome.
Journal of Infection
Brev til redaktøren
-
Ravlo, Erlend;
Sousa, Mirta;
Andresen, Lise Lima;
Holberg-Petersen, Mona;
Klundby, Ingvild;
Aas, Per Arne.
(2023)
A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles.
Scientific Reports
Vitenskapelig artikkel
-
Starheim, Eirin Johannessen;
Ravlo, Erlend;
Schjølberg, Jørn-Ove;
Solvang, Vanessa;
Wang, Wei;
Scrimgeour, Nathan Robert.
(2023)
NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA.
Scientific Reports
Vitenskapelig artikkel
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Vitenskapelig artikkel
2022
-
Olsen, Maria Belland;
Huse, Camilla;
Sousa, Mirta;
Murphy, Sarah Louise Mikalsen;
Sarno, Antonio;
Obermann, Tobias Sebastian.
(2022)
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients.
Journal of Inflammation Research
Vitenskapelig artikkel
-
Kaarbø, Mari;
Yang, Mingyi;
Hov, Johannes Espolin Roksund;
Holm, Kristian;
Sousa, Mirta;
Macpherson, Magnhild Eide.
(2022)
Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses.
Journal of Allergy and Clinical Immunology
Vitenskapelig artikkel
2021
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences
Vitenskapelig oversiktsartikkel/review
-
Maddirevula, Sateesh;
Alameer, Seham;
Ewida, Nour;
Sousa, Mirta;
Bjørås, Magnar;
Vågbø, Cathrine Broberg.
(2021)
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant.
Human Genetics
Vitenskapelig artikkel
2020
-
Yang, Mingyi;
Lin, Xiaolin;
Segers, Filip;
Suganthan, Rajikala;
Hildrestrand, Gunn Annette;
Rinholm, Johanne Egge.
(2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation.
Cell reports
Vitenskapelig artikkel
-
Quiles Jimenez, Ana Maria Teresa;
Gregersen, Ida;
Sousa, Mirta;
Abbas, Azhar;
Kong, Xiang Yi;
Alseth, Ingrun.
(2020)
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis.
Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
-
Iveland, Tobias Solli;
Hagen, Lars;
Sharma, Animesh;
Sousa, Mirta;
Sarno, Antonio;
Wollen, Kristian Lied.
(2020)
HDACi Mediate UNG2 Depletion, Dysregulated Genomic Uracil and Altered Expression of Oncoproteins and Tumor Suppressors in B- And T-cell Lines.
Journal of Translational Medicine
Vitenskapelig artikkel
2019
-
Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Parsons, H.T.;
Stevens, T.J.;
McFarlane, H.E.;
Vidal-Melgosa, Silvia;
Griss, Johannes;
Lawrence, Nicola.
(2019)
Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization.
The Plant Cell
Vitenskapelig artikkel
2017
-
Rydning, Siri Lynne;
Backe, Paul Hoff;
Sousa, Mirta;
Iqbal, Zafar;
Øye, Ane-Marte;
Sheng, Ying.
(2017)
Novel UCHL1 mutations reveal new insights into ubiquitin processing.
Human Molecular Genetics
Vitenskapelig artikkel
-
Bjørås, Karine;
Sousa, Mirta;
Sharma, Animesh;
Fonseca, Davi de Miranda;
Søgaard, Caroline Danielsen;
Bjørås, Magnar.
(2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Zatula, Alexey;
Dikic, Aida;
Mulder, Teska Celine;
Sharma, Animesh;
Vågbø, Cathrine Broberg;
Sousa, Mirta.
(2017)
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.
OncoTarget
Vitenskapelig artikkel
-
Sousa, Mirta;
Bjørås, Karine;
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Otterlei, Marit.
(2017)
P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.
Scientific Reports
Vitenskapelig artikkel
-
Vange, Pål;
Bruland, Torunn;
Doseth, Berit;
Fossmark, Reidar;
Sousa, Mirta;
Beisvag, Vidar.
(2017)
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival.
PLOS ONE
Vitenskapelig artikkel
-
Rydning, Siri Lynne;
Backe, Paul Hoff;
Sousa, Mirta;
Iqbal, Zafar;
Øye, Ane-Marte;
Sheng, Ying.
(2017)
Corrigendum: Novel UCHL1 mutations reveal new insights into ubiquitin processing.
Human Molecular Genetics
Errata
2016
-
Cambri, Geison;
Sousa, Mirta;
Fonseca, Davi de Miranda;
Marchini, Fabricio K.;
Meira da Silveira, Joana Lea;
Paba, Jaime.
(2016)
Analysis of the Biotechnological Potential of a Lentinus crinitus Isolate in the Light of Its Secretome.
Journal of Proteome Research
Vitenskapelig artikkel
-
Skarpengland, Tonje;
Dahl, Tuva Børresdatter;
Skjelland, Mona;
Scheffler, Katja;
Sousa, Mirta;
Gregersen, Ida.
(2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.
Free Radical Biology & Medicine
Vitenskapelig artikkel
2015
-
Weaver, Lane J;
Sousa, Mirta;
Wang, George;
Baidoo, Edward;
Petzold, Christopher J;
Keasling, Jay D..
(2015)
A kinetic-based approach to understanding heterologous mevalonate pathway function in E. coli.
Biotechnology and Bioengineering
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
-
Zub, Kamila;
Sousa, Mirta;
Sarno, Antonio;
Sharma, Animesh;
Dikic, Aida;
Rao, Shalini.
(2015)
Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired Melphalan resistance in multiple myeloma cells.
PLOS ONE
Vitenskapelig artikkel
-
Rolim, Natale Pinheiro Lage;
Skårdal, Kristine;
Høydal, Morten;
Sousa, Mirta;
Malmo, Vegard;
Skrove, Guri Kaurstad.
(2015)
Aerobic interval training reduces inducible ventricular arrhytmias in diabetic mice after myocardial infarction.
Basic Research in Cardiology
Vitenskapelig artikkel
2014
-
Batth, Tanveer S;
Singh, Pragya;
Ramakrishnan, Vikram R;
Sousa, Mirta;
Chan, Leanne Jade;
Tran, Huu M.
(2014)
A targeted proteomics toolkit for high-throughput absolute quantification of Escherichia coli proteins.
Metabolic Engineering
Vitenskapelig artikkel
2013
-
Johnsen, Anne Berit;
Rolim, Natale Pinheiro Lage;
Stølen, Tomas;
Alves, Marcia;
Sousa, Mirta;
Slupphaug, Geir.
(2013)
Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity.
PLOS ONE
Vitenskapelig artikkel
-
Sousa, Mirta;
Zub, Kamila Anna;
Aas, Per Arne;
Hanssen-Bauer, Audun;
Demirovic, Aida;
Sarno, Antonio.
(2013)
An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.
PLOS ONE
Vitenskapelig artikkel
-
Johannessen, Helene;
Kodama, Yosuke;
Zhao, Chun-Mei;
Sousa, Mirta;
Slupphaug, Geir;
Kulseng, Bård Eirik.
(2013)
Eating Behavior and Glucagon-Like Peptide-1-Producing Cells in Interposed Ileum and Pancreatic Islets in Rats Subjected to Ileal Interposition Associated with Sleeve Gastrectomy.
Obesity Surgery
Vitenskapelig artikkel
2011
-
Baglo, Yan;
Sousa, Mirta;
Slupphaug, Geir;
Hagen, Lars;
Håvåg, Sissel;
Helander, Linda.
(2011)
Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways.
Photochemical and Photobiological Sciences
Vitenskapelig artikkel
-
Sousa, Mirta;
Steen, Kristian Wollen;
Hagen, Lars;
Slupphaug, Geir.
(2011)
Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis.
Proteome Science
Vitenskapelig artikkel
2010
-
Monsen, Vivi A Talstad;
Sundheim, Ottar;
Aas, Per Arne;
Westbye, Marianne Pedersen;
Sousa, Mirta;
Slupphaug, Geir.
(2010)
Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2009
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel/review
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
2008
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
2007
-
Sousa, Mirta;
Krokan, Hans Einar;
Slupphaug, Geir.
(2007)
DNA-uracil and human pathology.
Molecular Aspects of Medicine
Vitenskapelig oversiktsartikkel/review
2006
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Neurauter, Christine Gran;
Pannone, Marco;
Sousa, Mirta;
Wang, Wei;
Kusnierczyk, Anna;
Luna, Luisa.
(2024)
Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells.
Free Radical Biology & Medicine
Vitenskapelig artikkel
-
Quiles-Jiménez, Ana M T;
Sousa, Mirta;
Huse, Camilla;
Dyrhol-Riise, Anne Ma;
Holter, Jan Cato;
Christensen, Erik Egeland.
(2023)
Severely ill COVID-19 patients have altered circulating levels of proteins controlling the epitranscriptome.
Journal of Infection
Brev til redaktøren
-
Ravlo, Erlend;
Sousa, Mirta;
Andresen, Lise Lima;
Holberg-Petersen, Mona;
Klundby, Ingvild;
Aas, Per Arne.
(2023)
A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles.
Scientific Reports
Vitenskapelig artikkel
-
Starheim, Eirin Johannessen;
Ravlo, Erlend;
Schjølberg, Jørn-Ove;
Solvang, Vanessa;
Wang, Wei;
Scrimgeour, Nathan Robert.
(2023)
NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA.
Scientific Reports
Vitenskapelig artikkel
-
Lin, Xiaolin;
Wang, Wei;
Yang, Mingyi;
Damseh, Nadirah;
Sousa, Mirta;
Jacob, Fadi.
(2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biology
Vitenskapelig artikkel
-
Olsen, Maria Belland;
Huse, Camilla;
Sousa, Mirta;
Murphy, Sarah Louise Mikalsen;
Sarno, Antonio;
Obermann, Tobias Sebastian.
(2022)
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients.
Journal of Inflammation Research
Vitenskapelig artikkel
-
Kaarbø, Mari;
Yang, Mingyi;
Hov, Johannes Espolin Roksund;
Holm, Kristian;
Sousa, Mirta;
Macpherson, Magnhild Eide.
(2022)
Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses.
Journal of Allergy and Clinical Immunology
Vitenskapelig artikkel
-
Sousa, Mirta;
Ye, Jing;
Gomez, Luisa Fernanda Luna;
Hildrestrand, Gunn Annette;
Bjørås, Karine;
Scheffler, Katja.
(2021)
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction.
International Journal of Molecular Sciences
Vitenskapelig oversiktsartikkel/review
-
Maddirevula, Sateesh;
Alameer, Seham;
Ewida, Nour;
Sousa, Mirta;
Bjørås, Magnar;
Vågbø, Cathrine Broberg.
(2021)
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant.
Human Genetics
Vitenskapelig artikkel
-
Yang, Mingyi;
Lin, Xiaolin;
Segers, Filip;
Suganthan, Rajikala;
Hildrestrand, Gunn Annette;
Rinholm, Johanne Egge.
(2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation.
Cell reports
Vitenskapelig artikkel
-
Quiles Jimenez, Ana Maria Teresa;
Gregersen, Ida;
Sousa, Mirta;
Abbas, Azhar;
Kong, Xiang Yi;
Alseth, Ingrun.
(2020)
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis.
Biochemical and Biophysical Research Communications - BBRC
Vitenskapelig artikkel
-
Iveland, Tobias Solli;
Hagen, Lars;
Sharma, Animesh;
Sousa, Mirta;
Sarno, Antonio;
Wollen, Kristian Lied.
(2020)
HDACi Mediate UNG2 Depletion, Dysregulated Genomic Uracil and Altered Expression of Oncoproteins and Tumor Suppressors in B- And T-cell Lines.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Sarno, Antonio;
Lundbæk, Marie Benner;
Liabakk, Nina-Beate;
Aas, Per Arne;
Mjelle, Robin;
Hagen, Lars.
(2019)
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Parsons, H.T.;
Stevens, T.J.;
McFarlane, H.E.;
Vidal-Melgosa, Silvia;
Griss, Johannes;
Lawrence, Nicola.
(2019)
Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization.
The Plant Cell
Vitenskapelig artikkel
-
Rydning, Siri Lynne;
Backe, Paul Hoff;
Sousa, Mirta;
Iqbal, Zafar;
Øye, Ane-Marte;
Sheng, Ying.
(2017)
Novel UCHL1 mutations reveal new insights into ubiquitin processing.
Human Molecular Genetics
Vitenskapelig artikkel
-
Bjørås, Karine;
Sousa, Mirta;
Sharma, Animesh;
Fonseca, Davi de Miranda;
Søgaard, Caroline Danielsen;
Bjørås, Magnar.
(2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Zatula, Alexey;
Dikic, Aida;
Mulder, Teska Celine;
Sharma, Animesh;
Vågbø, Cathrine Broberg;
Sousa, Mirta.
(2017)
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.
OncoTarget
Vitenskapelig artikkel
-
Sousa, Mirta;
Bjørås, Karine;
Hanssen-Bauer, Audun;
Solvang-Garten, Karin;
Otterlei, Marit.
(2017)
P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.
Scientific Reports
Vitenskapelig artikkel
-
Vange, Pål;
Bruland, Torunn;
Doseth, Berit;
Fossmark, Reidar;
Sousa, Mirta;
Beisvag, Vidar.
(2017)
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival.
PLOS ONE
Vitenskapelig artikkel
-
Rydning, Siri Lynne;
Backe, Paul Hoff;
Sousa, Mirta;
Iqbal, Zafar;
Øye, Ane-Marte;
Sheng, Ying.
(2017)
Corrigendum: Novel UCHL1 mutations reveal new insights into ubiquitin processing.
Human Molecular Genetics
Errata
-
Cambri, Geison;
Sousa, Mirta;
Fonseca, Davi de Miranda;
Marchini, Fabricio K.;
Meira da Silveira, Joana Lea;
Paba, Jaime.
(2016)
Analysis of the Biotechnological Potential of a Lentinus crinitus Isolate in the Light of Its Secretome.
Journal of Proteome Research
Vitenskapelig artikkel
-
Skarpengland, Tonje;
Dahl, Tuva Børresdatter;
Skjelland, Mona;
Scheffler, Katja;
Sousa, Mirta;
Gregersen, Ida.
(2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.
Free Radical Biology & Medicine
Vitenskapelig artikkel
-
Weaver, Lane J;
Sousa, Mirta;
Wang, George;
Baidoo, Edward;
Petzold, Christopher J;
Keasling, Jay D..
(2015)
A kinetic-based approach to understanding heterologous mevalonate pathway function in E. coli.
Biotechnology and Bioengineering
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Galashevskaya, Anastasia;
Doseth, Berit;
Sousa, Mirta;
Sarno, Antonio;
Visnes, Torkild.
(2015)
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair
Vitenskapelig artikkel
-
Zub, Kamila;
Sousa, Mirta;
Sarno, Antonio;
Sharma, Animesh;
Dikic, Aida;
Rao, Shalini.
(2015)
Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired Melphalan resistance in multiple myeloma cells.
PLOS ONE
Vitenskapelig artikkel
-
Rolim, Natale Pinheiro Lage;
Skårdal, Kristine;
Høydal, Morten;
Sousa, Mirta;
Malmo, Vegard;
Skrove, Guri Kaurstad.
(2015)
Aerobic interval training reduces inducible ventricular arrhytmias in diabetic mice after myocardial infarction.
Basic Research in Cardiology
Vitenskapelig artikkel
-
Batth, Tanveer S;
Singh, Pragya;
Ramakrishnan, Vikram R;
Sousa, Mirta;
Chan, Leanne Jade;
Tran, Huu M.
(2014)
A targeted proteomics toolkit for high-throughput absolute quantification of Escherichia coli proteins.
Metabolic Engineering
Vitenskapelig artikkel
-
Johnsen, Anne Berit;
Rolim, Natale Pinheiro Lage;
Stølen, Tomas;
Alves, Marcia;
Sousa, Mirta;
Slupphaug, Geir.
(2013)
Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity.
PLOS ONE
Vitenskapelig artikkel
-
Sousa, Mirta;
Zub, Kamila Anna;
Aas, Per Arne;
Hanssen-Bauer, Audun;
Demirovic, Aida;
Sarno, Antonio.
(2013)
An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.
PLOS ONE
Vitenskapelig artikkel
-
Johannessen, Helene;
Kodama, Yosuke;
Zhao, Chun-Mei;
Sousa, Mirta;
Slupphaug, Geir;
Kulseng, Bård Eirik.
(2013)
Eating Behavior and Glucagon-Like Peptide-1-Producing Cells in Interposed Ileum and Pancreatic Islets in Rats Subjected to Ileal Interposition Associated with Sleeve Gastrectomy.
Obesity Surgery
Vitenskapelig artikkel
-
Baglo, Yan;
Sousa, Mirta;
Slupphaug, Geir;
Hagen, Lars;
Håvåg, Sissel;
Helander, Linda.
(2011)
Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways.
Photochemical and Photobiological Sciences
Vitenskapelig artikkel
-
Sousa, Mirta;
Steen, Kristian Wollen;
Hagen, Lars;
Slupphaug, Geir.
(2011)
Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis.
Proteome Science
Vitenskapelig artikkel
-
Monsen, Vivi A Talstad;
Sundheim, Ottar;
Aas, Per Arne;
Westbye, Marianne Pedersen;
Sousa, Mirta;
Slupphaug, Geir.
(2010)
Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Visnes, Torkild;
Doseth, Berit;
Pettersen, Henrik Sahlin;
Hagen, Lars;
Sousa, Mirta;
Akbari, Mansour.
(2009)
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical Transactions of the Royal Society of London. Biological Sciences
Vitenskapelig oversiktsartikkel/review
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
-
Hagen, Lars;
Kavli, Bodil Merete;
Sousa, Mirta;
Torseth, Kathrin;
Liabakk, Nina-Beate;
Sundheim, Ottar.
(2008)
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
EMBO Journal
Vitenskapelig artikkel
-
Sousa, Mirta;
Krokan, Hans Einar;
Slupphaug, Geir.
(2007)
DNA-uracil and human pathology.
Molecular Aspects of Medicine
Vitenskapelig oversiktsartikkel/review
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
Formidling
2016
-
Faglig foredragSousa, Mirta. (2016) Principles of targeted proteomics. Myeloma group meeting , Kunnskapsenter (KM42) 2016-03-31 - 2016-03-31
-
Vitenskapelig foredragVange, Pål; Bruland, Torunn; Doseth, Berit; Sousa, Mirta; Sørdal, Øystein Finset; Qvigstad, Gunnar. (2016) The anti-apoptotic factor clusterin is involved in hypergastrinemia-induced remodeling of the gastric oxyntic mucosa. United European Gastroenterology Week 2016 , Wien 2016-10-17 - 2016-10-19
-
Faglig foredragKrokan, Hans Einar; Slupphaug, Geir; Sætrom, Pål; Sarno, Antonio; Galashevskaya, Anastasia; Lundbæk, Marie Benner. (2016) Genomic uracil - Important carcinogenic mutagen but normal intermediate in adaptive immunity. Turkish Society of Toxicology. Eurotox 2016 , Sivilla 2016-09-04 -
2015
-
Faglig foredragSousa, Mirta. (2015) Protein Quantification Through Targeted Proteomics. Institutt dagen - IKM 2015-04-16 - 2015-04-16
-
Faglig foredragSousa, Mirta. (2015) Principles of targeted proteomics and its applications in cancer research. Norsk Biokjemisk Selskap (NBS) 2015 , Granen Hotell, Åre 2015-03-03 - 2015-03-04
2014
-
PosterSingh, Pragya; Batth, Tanveer S; Ramakrishnan, Vikram R; Sousa, Mirta; Chan, Leanne Jade; Keasling, Jay D. (2014) An SRM toolkit for “faster-better-cheaper” absolute quantification of Escherichia coli pathway proteins. ASMS The American Society of Mass Spectrometry (ASMS) - 62nd Annual Conference , Baltimore, MD, USA 2014-06-15 - 2014-06-19
-
PosterZatula, Alexey; Demirovic, Aida; Sharma, Animesh; Sousa, Mirta; Sundan, Anders; Slupphaug, Geir. (2014) Biomarker discovery and subtype classification within Multiple Myeloma by Super-SILAC. 2014 Nordic Proteomics Conference , Turku 2014-03-11 - 2014-03-13
-
PosterGebriel, Mohammed; Zatula, Alexey; Sousa, Mirta; Hagen, Lars; Slupphaug, Geir. (2014) From tissue to protein networks in (a bit more than) two hours: an ultrafast and a straightforward single-run LC-MS/MS approach for comprehensive proteome analyses. Norwegian Biochemical Society NBS Contact Meeting 2014 , Røros 2014-01-23 - 2014-01-26
-
PosterGebriel, Mohammed; Sousa, Mirta; Slupphaug, Geir. (2014) Global Proteomic monitoring of Phosphoproteome dynamics during rotenone-induced apoptosis in HeLa cells. Norwegian Biochemical Society NBS Contact Meeting 2014 , Røros 2014-01-23 - 2014-01-26
2013
-
Vitenskapelig foredragSousa, Mirta; Slupphaug, Geir. (2013) Targeted Quantitation of Proteins by Mass Spectrometry. IKM - NTNU Monday Meeting - IKM 2013-11-25 - 2013-11-25
-
PosterParsons, Harriet; Petzold, Christopher J; Verhertbruggen, Yves; Lao, Jeemeng; Sousa, Mirta; Scheller, Henrik. (2013) Separation of the Arabidopsis secretory pathway. Joint BioEnergy Institute 2013 JBEI Annual Summer Retreat 2013-06-26 - 2013-06-28
-
Vitenskapelig foredragSousa, Mirta; Slupphaug, Geir. (2013) Biomarker discovery in multiple myeloma by targeted absolute quantitative proteomics. Pr. Trent Northen - Lawrence Berkeley National Laboratory Trent Northen Group Meeting , Lawrence Berkeley National Laboratory, Berkeley 2013-03-05 - 2013-03-05
-
PosterSousa, Mirta; Batth, Tanveer S; Singh, Pragya; M Tran, Huu; Ramakrishnan, Vikram R; Keasling, Jay D. (2013) Targeted Proteomics of Metabolically Engineered E. coli. Joint BioEnergy Institute 2013 JBEI Annual Summer Retreat 2013-06-26 - 2013-06-28
-
PosterSousa, Mirta; Batth, Tanveer S; Singh, Pragya; Ramakrishnan, Vikram R; Keasling, Jay D; Adams, Paul D. (2013) Targeted Proteomics of Metabolically Engineered E. coli. Joint BioEnergy Institute, JBEI Industry Advisory Committee (IAC) and Scientific Advisory Committee (SAC) Meetings , JBEI, Emeryville, CA 2013-06-12 - 2013-06-14
2012
-
Vitenskapelig foredragSousa, Mirta. (2012) Melphalan resistance in myeloma cells. NTNU Onsdag møte 2012-04-25 - 2012-04-25
2011
-
PosterBaglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda. (2011) Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. University of Dublin Cancer Proteomics 2011, European Molecular Biology Organization , The Burlington Hotel, Dublin 2011-06-20 - 2011-06-23
-
Vitenskapelig foredragSousa, Mirta. (2011) Signaling response and DNA repair pathways involved in acquired melphalan resistance in myeloma cells. NTNU Monday meeting - IKM 2011-09-19 - 2011-09-19
-
PosterSousa, Mirta; Zub, Kamila; Aas, Per Arne; Tian, Erming; Liabakk, Nina-Beate; Young, Clifford. (2011) Switch in ATM/ATR expression and up-regulation of NHEJ proteins contribute to acquired melphalan resistance in RPMI8226 myeloma cells. 2nd nordic proteomics symposium , Copenhagen 2011-11-27 - 2011-11-29
-
PosterSousa, Mirta; Zub, Kamila; Aas, Per Arne; Young, Clifford; Tian, Erming; Jensen, Ole Nørregaard. (2011) Proteomics screening identifies AKR1C proteins as potential markers for resistance in melphalan resistant RPMI8226-LR5 myeloma cells. 4th EU-USA conference on DNA base damage and repair , Oslo 2011-05-18 - 2011-05-22
2010
-
Vitenskapelig foredragSousa, Mirta. (2010) Multiple Myeloma. IKM - NTNU Monday meeting , trondheim 2010-10-25 - 2010-10-25
-
Vitenskapelig foredragZub, Kamila; Sousa, Mirta; Aas, Per Arne; Young, Clifford; Tian, Erming; Johansen, Jostein. (2010) A proteomics and genomic approach to identify factors associated with melphalan resistance in multiple myeloma cells. NTNU 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
-
Vitenskapelig foredragSousa, Mirta; Steen, Kristian Wollen; Hagen, Lars; Slupphaug, Geir. (2010) Antibody crosslinking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis. NTNU 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
-
Vitenskapelig foredragHagen, Lars; Kavli, Bodil Merete; Sousa, Mirta; Torseth, Kathrin; Slupphaug, Geir. (2010) Post translational modifications of the human DNA repair protein uracil DNA glycosylase, UNG2. 6th Norwegian National Proteomics Meeting 2010-12-09 - 2010-12-10
2009
-
Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair 2009-06-20 - 2009-06-25
-
PosterZub, Kamila; Sousa, Mirta; Young, Clifford; Tian, Erming; Hagen, Lars; Slupphaug, Geir. (2009) Differential protein expression in melphalan sensitive and resistant multiple myeloma cells revealed by SILAC-based quantitative proteomics. 5th Norwegian National Proteomics meeting , Bergen 2009-10-26 - 2009-10-27
-
PosterZub, Kamila; Sousa, Mirta; Young, Clifford; Tian, Erming; Johansen, Jostein; Hagen, Lars. (2009) What a difference melphalan makes! Differential protein expression in melphalan resistant and sensitive multiple myeloma cells using SILAC analysis. Select Biosciences Proteomics Europe , Barcelona 2009-11-05 - 2009-11-06
-
PosterSousa, Mirta; Tian, Erming; Hanssen-Bauer, Audun; Zub, Kamila; Banica, Ana; Slupphaug, Geir. (2009) MBD4 is a candidate protein in development of drug resistance in multiple myeloma. The norwegian biochemical society 45th contact meeting , Røros 2009-01-29 - 2009-02-01
2008
-
Vitenskapelig foredragSousa, Mirta. (2008) Induced DNA damage by Melphalan, an alkylating drug used in multiple myeloma treatment. NTNU-IKM monday meeting 2008-09-29 - 2008-09-29
2007
-
Vitenskapelig foredragSousa, Mirta. (2007) 2D fluorescence difference gel electrophoresis (2D DIGE). NTNU - IKM 2007-11-19 - 2007-11-19
2006
-
PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Talstad, Vivi; Aas, Per Arne. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Erling Seeberg Symposium on DNA Repair 2006-05-28 - 2006-06-02
-
PosterSousa, Mirta; Sundheim, Ottar; Vågbø, Cathrine Broberg; Talstad, Vivi; Aslaksen, Petter Broby; Slupphaug, Geir. (2006) Post-translational self-hydroxilation of an active site leucine in human ABH3 may protect against generation of damaging oxygen radicals. Erling Seeberg Symposium on DNA Repair , Bodø og Hennigsvær 2006-05-28 - 2006-06-02
-
PosterHagen, Lars; Kavli, Bodil Merete; Sundheim, Ottar; Sousa, Mirta; Otterlei, Marit; Liabakk, Nina-Beate. (2006) Regulation of uracil base excision repair by post-translational modifications. Erling Seeberg Symposium on DNA Repair 2006-05-28 - 2006-06-02
-
PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2006) Crystal structure of hABH3 DNA/RNA demethylase reveals a novel active-site leucine oxidation. Norwegian Biochemical Society (NBS) The Norwegian Biochemical Society 42. Contact Meeting , Storefjell, Storefjell Hotell 2006-01-19 - 2006-01-22
2005
-
PosterDiaz, Javier Pena; Hegre, Siv Anita; Akbari, Mansour; Sousa, Mirta; Sundheim, Ottar; Hanssen-Bauer, Audun. (2005) Recruitment of the chaperone Hsp70 to Base Excision Repair complexes. 2nd EU-US DNA RepairMeeting 2005-11-29 - 2005-12-03
-
PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2005) Structure of the hABH3 DNA demethylase implicates an oxidized leucine residue in catalysis. 2nd ESF Functional Genomics and disease 2005-09-06 -