Kristian Starheim
Om
Inflammatory Cell Death Group.
We are a research group situated at the Centre for Molecular Inflammation Research (Cemir), a Norwegian Research Council Centre of Excellence. We are affiliated with the Autophagy and Oxidative Stress Group and the Centre of Myeloma Research. Our focus is regulation and targeting of inflammatory cell death pathways in the monocytic lineage.
We have terminated our research activity and are not accepting students.
Research.
Regulated cell death types such as apoptosis, necroptosis and pyroptosis are central in a wide range of physiological and pathological states throughout the organism. Understanding how cells initiate or suppress cell death in response to challenges such as drugs or bacterial infections is important to understand both immune responses, cellular homeostasis and drug cytotoxicity.
Our research focus is on how intracellular protection mechanisms and cell death pathways tackle stressors such as chemotherapeutic drugs, danger-associated and pathogen-associated molecular patterns (DAMPs and PAMPs). We focus on the role of the RIPK1- and RIPK3-regulated death pathways in inflammation.
Interestingly, cell death pathways are often interconnected with pathways for proliferation and cytokine production. They take important roles in both drug resistance and inflammation. De-regulation of these pathways can lead to malignant states such as cancer and cronic inflammation.
Members.
Kristian K. Starheim, Principle Investigator
Ingrid Nyhus Moen, PhD-Candidate
Erling Håland, Medical Student, research program for medical students.
Work experience Starheim.
2016-present: Researcher, Centre for Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), Trondheim Norway. Young researcher qualifying grant from The Norwegian Cancer Society.
2014-2015: Visiting post doctoral researcher, UMass Medical School, Dept. Infectious diseases, Worcester MA, US.
2013-2015: Post doctoral researcher, CEMIR, NTNU.
2012 Aug-Dec: Research fellow, K.G. Jebsen Centre for Myeloma Research, NTNU
2012 Feb-Jul: Visiting scientist, NTNU.
2011 Feb - Jul: Visiting scientist, Instituto Gulbenkian de Ciência, Oeiras, Portugal.
2008 - 2012: PhD Fellowship, Dep. of Surgical Sciences/Dep. of Molecular Biology, UiB
2007 - 2008: Scientific assistant, Dep. Surgical Sciences/Dep. Molecular Biology, UiB.
Education
2008 - 2011: Master of Philosophy, University of Bergen (UiB).
2008 - 2010: PhD, Dep. Surgical Sciences/Dep. Molecular Biology, UiB.
2003 - 2008: Undergraduate studies, Dep. Philosophy, UiB.
2005 - 2007: Master of Science, Molecular Biology, UiB.
2002 - 2005: Bachelor of Science, Molecular Biology, UiB.
Publikasjoner
2019
-
Skjesol, Astrid;
Yurchenko, Mariya;
Bösl, Korbinian;
Gravastrand, Caroline S.;
Nilsen, Kaja Elisabeth;
Grøvdal, Lene Melsæther.
(2019)
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
PLoS Pathogens
Vitenskapelig artikkel
2018
-
Ørning, Mathias Pontus Andreas;
Weng, Dan;
Starheim, Kristian K.;
Ratner, Dmitry;
Best, Zachary;
Lee, Bettina.
(2018)
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Science
Vitenskapelig artikkel
2017
-
Starheim, Kristian K.;
Kalvik, Thomas Vikestad;
Bjørkøy, Geir;
Arnesen, Thomas.
(2017)
Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization.
Bioscience Reports
Vitenskapelig artikkel
2016
-
Baranowska, Katarzyna Anna;
Misund, Kristine;
Starheim, Kristian K.;
Holien, Toril;
Johansson, Ida;
Darvekar, Sagar.
(2016)
Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.
OncoTarget
Vitenskapelig artikkel
-
Van Damme, Petra;
Kalvik, Thomas Vikestad;
Starheim, Kristian K.;
Jonckheere, Veronique;
Myklebust, Line Merethe;
Menschaert, Gerben.
(2016)
A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity.
Molecular & Cellular Proteomics
Vitenskapelig artikkel
-
Starheim, Kristian Kobbenes;
Holien, Toril;
Misund, Kristine;
Johansson, Ida;
Baranowska, Katarzyna Anna;
Sponaas, Anne Marit.
(2016)
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Blood Cancer Journal
Vitenskapelig artikkel
-
Ratner, Dmitry;
Ørning, Mathias Pontus;
Starheim, Kristian Kobbenes;
Marty-Roix, Robyn;
Proulx, MK;
Goguen, JD.
(2016)
Manipulation of interleukin-1β and interleukin-18 production by yersinia pestis effectors YopJ and YopM and redundant impact on virulence.
Journal of Biological Chemistry
Vitenskapelig artikkel
2015
-
Aksnes, Henriette;
Van Damme, Petra;
Goris, Marianne;
Starheim, Kristian K.;
Marie, Michael Bruno Eric;
Støve, Svein Isungset.
(2015)
An organellar Nα-acetyltransferase, Naa60, acetylates cytosolic n termini of transmembrane proteins and maintains golgi integrity.
Cell reports
Vitenskapelig artikkel
2013
-
Starheim, Kristian K..
(2013)
Molekylær medisin som uttalt hybrid aktivitet - Å omsetje Latour tilbake til laboratoriet.
Agora
Vitenskapelig artikkel
2012
-
Starheim, Kristian Kobbenes;
Gevaert, Kris;
Arnesen, Thomas.
(2012)
Protein N-terminal acetyltransferases: when the start matters.
TIBS -Trends in Biochemical Sciences. Regular ed.
Vitenskapelig oversiktsartikkel/review
2011
-
Starheim, Kristian Kobbenes;
De Cuzzani , Paola Maria;
Strand, Roger.
(2011)
Knowledge production in experimental molecular medicine - Primers for a reflexive life knowledge.
Universitetet i Bergen
Universitetet i Bergen
Mastergradsoppgave
2010
-
Arnesen, Thomas;
Starheim, Kristian Kobbenes;
Van Damme, Petra;
Evjenth, Rune Henrik;
Dinh, Huyen Mong Thi;
Betts, Matthew James.
(2010)
The Chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation.
Molecular and Cellular Biology
Vitenskapelig artikkel
-
Starheim, Kristian Kobbenes.
(2010)
The human protein N-α-acetyltransferase complexes hNatA, hNatB, and hNatC.
Universitetet i Bergen
Universitetet i Bergen
Doktorgradsavhandling
2009
-
Arnesen, Thomas;
Gromyko, Darina;
Kagabo, Diane;
Betts, Matthew James;
Starheim, Kristian Kobbenes;
Varhaug, Jan Erik.
(2009)
A novel human NatA N-alpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1).
BMC Biochemistry
Vitenskapelig artikkel
-
Starheim, Kristian Kobbenes;
Gromyko, Darina;
Evjenth, Rune Henrik;
Ryningen, Anita;
Varhaug, Jan Erik;
Lillehaug, Johan.
(2009)
Knockdown of the human N-alpha-acetyltransferace complex C (hNatC) leads to p53-dependent apoptosis and aberrant hArl8b localization.
Molecular and Cellular Biology
Vitenskapelig artikkel
-
Starheim, Kristian Kobbenes;
Gromyko, Darina;
Velde, Rolf Sturla;
Varhaug, Jan Erik;
Arnesen, Thomas.
(2009)
Composition and biological significance of the human N-alpha-terminal acetyltransferases.
BMC Proceedings
Vitenskapelig oversiktsartikkel/review
2008
-
Starheim, Kristian Kobbenes;
Arnesen, Thomas;
Gromyko, Darina;
Ryningen, Anita;
Varhaug, Jan Erik;
Lillehaug, Johan.
(2008)
Identification of the human N-alpha-acetyltransferase complex B (hnatB): a complex important for cell-cycle progression.
Biochemical Journal
Vitenskapelig artikkel
2007
-
Starheim, Kristian Kobbenes;
Lillehaug, Johan;
Arnesen, Thomas.
(2007)
A study of novel N-alpha-acetyltransferase complexes NatB & NatC.
Universitetet i Bergen
Universitetet i Bergen
Mastergradsoppgave
Tidsskriftspublikasjoner
-
Skjesol, Astrid;
Yurchenko, Mariya;
Bösl, Korbinian;
Gravastrand, Caroline S.;
Nilsen, Kaja Elisabeth;
Grøvdal, Lene Melsæther.
(2019)
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
PLoS Pathogens
Vitenskapelig artikkel
-
Ørning, Mathias Pontus Andreas;
Weng, Dan;
Starheim, Kristian K.;
Ratner, Dmitry;
Best, Zachary;
Lee, Bettina.
(2018)
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Science
Vitenskapelig artikkel
-
Starheim, Kristian K.;
Kalvik, Thomas Vikestad;
Bjørkøy, Geir;
Arnesen, Thomas.
(2017)
Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization.
Bioscience Reports
Vitenskapelig artikkel
-
Baranowska, Katarzyna Anna;
Misund, Kristine;
Starheim, Kristian K.;
Holien, Toril;
Johansson, Ida;
Darvekar, Sagar.
(2016)
Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.
OncoTarget
Vitenskapelig artikkel
-
Van Damme, Petra;
Kalvik, Thomas Vikestad;
Starheim, Kristian K.;
Jonckheere, Veronique;
Myklebust, Line Merethe;
Menschaert, Gerben.
(2016)
A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity.
Molecular & Cellular Proteomics
Vitenskapelig artikkel
-
Starheim, Kristian Kobbenes;
Holien, Toril;
Misund, Kristine;
Johansson, Ida;
Baranowska, Katarzyna Anna;
Sponaas, Anne Marit.
(2016)
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Blood Cancer Journal
Vitenskapelig artikkel
-
Ratner, Dmitry;
Ørning, Mathias Pontus;
Starheim, Kristian Kobbenes;
Marty-Roix, Robyn;
Proulx, MK;
Goguen, JD.
(2016)
Manipulation of interleukin-1β and interleukin-18 production by yersinia pestis effectors YopJ and YopM and redundant impact on virulence.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Aksnes, Henriette;
Van Damme, Petra;
Goris, Marianne;
Starheim, Kristian K.;
Marie, Michael Bruno Eric;
Støve, Svein Isungset.
(2015)
An organellar Nα-acetyltransferase, Naa60, acetylates cytosolic n termini of transmembrane proteins and maintains golgi integrity.
Cell reports
Vitenskapelig artikkel
-
Starheim, Kristian K..
(2013)
Molekylær medisin som uttalt hybrid aktivitet - Å omsetje Latour tilbake til laboratoriet.
Agora
Vitenskapelig artikkel
-
Starheim, Kristian Kobbenes;
Gevaert, Kris;
Arnesen, Thomas.
(2012)
Protein N-terminal acetyltransferases: when the start matters.
TIBS -Trends in Biochemical Sciences. Regular ed.
Vitenskapelig oversiktsartikkel/review
-
Arnesen, Thomas;
Starheim, Kristian Kobbenes;
Van Damme, Petra;
Evjenth, Rune Henrik;
Dinh, Huyen Mong Thi;
Betts, Matthew James.
(2010)
The Chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation.
Molecular and Cellular Biology
Vitenskapelig artikkel
-
Arnesen, Thomas;
Gromyko, Darina;
Kagabo, Diane;
Betts, Matthew James;
Starheim, Kristian Kobbenes;
Varhaug, Jan Erik.
(2009)
A novel human NatA N-alpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1).
BMC Biochemistry
Vitenskapelig artikkel
-
Starheim, Kristian Kobbenes;
Gromyko, Darina;
Evjenth, Rune Henrik;
Ryningen, Anita;
Varhaug, Jan Erik;
Lillehaug, Johan.
(2009)
Knockdown of the human N-alpha-acetyltransferace complex C (hNatC) leads to p53-dependent apoptosis and aberrant hArl8b localization.
Molecular and Cellular Biology
Vitenskapelig artikkel
-
Starheim, Kristian Kobbenes;
Gromyko, Darina;
Velde, Rolf Sturla;
Varhaug, Jan Erik;
Arnesen, Thomas.
(2009)
Composition and biological significance of the human N-alpha-terminal acetyltransferases.
BMC Proceedings
Vitenskapelig oversiktsartikkel/review
-
Starheim, Kristian Kobbenes;
Arnesen, Thomas;
Gromyko, Darina;
Ryningen, Anita;
Varhaug, Jan Erik;
Lillehaug, Johan.
(2008)
Identification of the human N-alpha-acetyltransferase complex B (hnatB): a complex important for cell-cycle progression.
Biochemical Journal
Vitenskapelig artikkel
Rapport
-
Starheim, Kristian Kobbenes;
De Cuzzani , Paola Maria;
Strand, Roger.
(2011)
Knowledge production in experimental molecular medicine - Primers for a reflexive life knowledge.
Universitetet i Bergen
Universitetet i Bergen
Mastergradsoppgave
-
Starheim, Kristian Kobbenes.
(2010)
The human protein N-α-acetyltransferase complexes hNatA, hNatB, and hNatC.
Universitetet i Bergen
Universitetet i Bergen
Doktorgradsavhandling
-
Starheim, Kristian Kobbenes;
Lillehaug, Johan;
Arnesen, Thomas.
(2007)
A study of novel N-alpha-acetyltransferase complexes NatB & NatC.
Universitetet i Bergen
Universitetet i Bergen
Mastergradsoppgave