Cathrine Broberg Vågbø
Om
Jeg har doktorgrad i molekylærmedisin og er ansatt ved kjernefasiliteten Proteomics and Modomics Experimental Core (PROMEC), Institutt for klinisk og molekylær medisin, NTNU.
Mitt spesialområde er RNA-epitranskriptomikk og DNA-epigenetikk som regulerer genuttrykk og gjennom det de fleste cellulære prosesser. Mitt primære mål er å bidra til å øke vår forståelse av hvordan feil i disse systemene forårsaker sykdom. Jeg har 20 års erfaring med analytiske teknikker som kromatografi og massespektrometri, og utvikling av metoder for å karakterisere kjemiske RNA- og DNA-modifikasjoner har stått sentralt i arbeidet mitt. I dag er disse metodene en del av PROMEC-repertoaret hvor de brukes av en rekke forskningsgrupper nasjonalt og internasjonalt.
Publikasjoner
Publisert 41 artikler (PubMed) i fagfellevurderte internasjonale tidsskrift, >5000 siteringer, h-index 27 (Publons).
Statistikk: Journal (impact factor, antall publikasjoner): Nature (69.5, 3), Cell (41.6, 1), Nat Neurosci (28.1, 1), Mol Cell (19.3, 2), Nucleic Acids Res (19.1, 6), Sci Adv (14.1, 1), Genes&Dev (12.9, 2), Nat Commun (17.7, 2), EMBO J (13.8, 2), Am J Hum Genet (11.0, 1), Cell Rep (10.0, 2), J Cell Biol (8.1, 1), Oncotarget (6.0, 1), J Transl Med (5.5, 1), Epigenet Chromatin (5.2, 1), DNA Rep (4.9, 5), J Biol Chem (4.6, 1), Cell Discov (4.5, 1), Sci Rep (4.5, 1), Mol Cell Biol (4.4, 1), Hum Genet (5.2, 1), PlosOne (3.5, 1), J Pharmacol Exp Ther (3.0, 1), F1000Res (1.7, 1), J Clin Pharm (1.7, 1).
Forfattet lærebokkapittel: Genomic Uracil: Evolution, Biology, Immunology and Disease, ISBN 9813233494, World Scientific publishing (2018).
Publikasjoner
2024
-
Schwarz, Simon D.;
Xu, Jianming;
Gunasekera, Kapila;
Schürmann, David;
Vågbø, Cathrine Broberg;
Ferrari, Elena.
(2024)
Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation.
Nature Communications
Vitenskapelig artikkel
2023
-
Sherwood, Anna V.;
Rivera-Rangel, Lizandro R.;
Ryberg, Line A.;
Larsen, Helena S.;
Anker, Klara M.;
Costa, Rui.
(2023)
Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide.
Nature
Vitenskapelig artikkel
-
Dohnalkova, Michaela;
Krasnykov, Kyrylo;
Mendel, Mateusz;
Li, Lingyun;
Panasenko, Olesya;
Fleury-Olela, Fabienne.
(2023)
Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility.
Cell reports
Vitenskapelig artikkel
-
Hayran , Abdul Baset ;
Liabakk, Nina-Beate;
Aas, Per Arne;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Sarno, Antonio.
(2023)
RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2022
-
Emdal, Elisabeth Fritzke;
Ottestad, Anine Larsen;
Vågbø, Cathrine Broberg;
Skarpeteig, Veronica ;
Rye, Morten Beck.
(2022)
Prøv deg som en DNA-detektiv.
Forskningstorget 2022
Annen presentasjon
-
Eftedal, Ingrid;
Vågbø, Cathrine Broberg;
Lund, Hedda Juni.
(2022)
Quantification of guanine-derived urinary biomarkers of oxidative stress in saturation divers by LC-MS/MS.
Norges Teknisk Naturvitenskaplige Universitet
Mastergradsoppgave
2021
-
Mendel, Mateusz;
Delaney, Kamila;
Pandey, Radha Raman;
Chen, Kuan-Ming;
Wenda, Joanna M.;
Vågbø, Cathrine Broberg.
(2021)
Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Cell
Vitenskapelig artikkel
-
Steen, Kristian Wollen;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Rabe, Renana;
Iveland, Tobias Solli;
Aas, Per Arne.
(2021)
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Maddirevula, Sateesh;
Alameer, Seham;
Ewida, Nour;
Sousa, Mirta;
Bjørås, Magnar;
Vågbø, Cathrine Broberg.
(2021)
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant.
Human Genetics
Vitenskapelig artikkel
2020
-
Boeckemeier, L;
Kraehenbuehl, R;
Keszthelyi, A;
Gasasira, MU;
Vernon, EG;
Beardmore, R.
(2020)
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.
Science Advances
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Slupphaug, Geir.
(2020)
RNA in DNA repair.
DNA Repair
Vitenskapelig artikkel
-
Kong, Xiang Yi;
Vik, Erik Sebastian;
Nawaz, Meh Sameen;
Berges, Natalia;
Dahl, Tuva Børresdatter;
Vågbø, Cathrine.
(2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Schär, Primo;
Schuermann, David;
Schwarz, Simon D.;
Grundbacher, Eliane;
Hrovat, Alexandra M.;
Xu, Jianming.
(2020)
Inducible TDG knockout models to study epigenetic regulation.
F1000
Vitenskapelig artikkel
-
Pandey, Radha Raman;
Delfino, Elena;
Homolka, David;
Roithova, Adriana;
Chen, Kuan-Ming;
Li, Lingyun.
(2020)
The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.
Cell reports
Vitenskapelig artikkel
2019
-
Monies, Dorota;
Vågbø, Cathrine Broberg;
Al-Owain, Mohammad;
Alhomaidi, Suzan;
Alkuraya, Fowzan S..
(2019)
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification.
American Journal of Human Genetics
Vitenskapelig artikkel
-
Pinto, Rita;
Vågbø, Cathrine Broberg;
Jakobsson, Magnus;
Yeji, Kim;
Baltissen, Marijke P;
O'Donohue, Marie-Francoise.
(2019)
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Li, Xiang;
Zhao, Qiongyi;
Wei, Wei;
Lin, Quan;
Magnan, Christophe;
Emami, Michael R.
(2019)
The DNA modification N6-methyl-2 '-eoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.
Nature Neuroscience
Vitenskapelig artikkel
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Vitenskapelig artikkel
2017
-
Brickner, Joshua R;
Soll, Jennifer M;
Lombardi, Patrick M;
Vågbø, Cathrine Broberg;
Mudge, Miranda C;
Oyeniran, Clement.
(2017)
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Nature
Vitenskapelig artikkel
-
Zatula, Alexey;
Dikic, Aida;
Mulder, Teska Celine;
Sharma, Animesh;
Vågbø, Cathrine Broberg;
Sousa, Mirta.
(2017)
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.
OncoTarget
Vitenskapelig artikkel
-
Landfors, Miriam;
Johansen, Jostein;
Aronsen, Jan Magnus;
Vågbø, Cathrine Broberg;
Doré, Louis C.;
He, Chuan.
(2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Cell Discovery
Vitenskapelig artikkel
-
Ke, Shengdong;
Pandya-Jones, Amy;
Saito, Yuhki;
Fak, John J.;
Vågbø, Cathrine Broberg;
Geula, Shay.
(2017)
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.
Genes & Development
Vitenskapelig artikkel
2016
-
Tekpli, Xavier;
Urbanucci, Alfonso;
Hashim, Adnan;
Vågbø, Cathrine Broberg;
Lyle, Robert;
Kringen, Marianne K..
(2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.
Epigenetics & Chromatin
Vitenskapelig artikkel
-
Weber, Alain R.;
Krawczyk, Claudia;
Robertson, Adam Brian;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Schürmann, David.
(2016)
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.
Nature Communications
Vitenskapelig artikkel
-
Rasmussen, Erik;
Vågbø, Cathrine Broberg;
Münch, Daniel;
Krokan, Hans Einar;
Klungland, Arne;
Amdam, Gro Vang.
(2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.
Biochemistry and Biophysics Reports
Vitenskapelig artikkel
2015
-
Ke, Shengdong;
Alemu, Endalkachew Ashenafi;
Mertens, Claudia;
Gantman, Emily Conn;
Fak, John J.;
Mele, Aldo.
(2015)
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes & Development
Vitenskapelig artikkel
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports
Vitenskapelig artikkel
2014
-
Zdzalik, Daria;
Vågbø, Cathrine Broberg;
Kirpekar, F;
Davydova, Erna;
Puścian, Alicja;
Maciejewska, Agnieszka M..
(2014)
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities.
PLOS ONE
Vitenskapelig artikkel
2013
-
Jobert, Laure;
Skjeldam, Hanne Kim;
Dalhus, Bjørn;
Galashevskaya, Anastasia;
Vågbø, Cathrine Broberg;
Bjørås, Magnar.
(2013)
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Molecular Cell
Vitenskapelig artikkel
-
Zheng, Guanqun;
Dahl, John Arne;
Niu, Yamei;
Fedorcsak, Peter;
Huang, Chun-Min;
Li, Charles J..
(2013)
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility.
Molecular Cell
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Vitenskapelig artikkel
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Vitenskapelig artikkel
2012
-
Meza, Trine Johansen;
Moen, Marivi;
Vågbø, Cathrine Broberg;
Krokan, Hans Einar;
Klungland, Arne;
Grini, Paul Eivind.
(2012)
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2011
-
Van den Born, Erwin;
Vågbø, Cathrine Broberg;
Songe-Møller, Lene;
Leihne, VIbeke;
Lien, Guro Flor;
Leszczynska, G.
(2011)
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nature Communications
Vitenskapelig artikkel
-
Robertson, Adam Brian;
Dahl, John Arne;
Vågbø, Cathrine Broberg;
Tripathi, P;
Krokan, Hans Einar;
Klungland, Arne.
(2011)
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Leihne, VIbeke;
Kirpekar, F;
Vågbø, Cathrine Broberg;
Van den Born, Erwin;
Krokan, Hans Einar;
Grini, Paul Eivind.
(2011)
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
2010
-
Songe-Møller, Lene;
Van den Born, Erwin;
Leihne, V;
Vågbø, Cathrine Broberg;
Kristoffersen, T;
Krokan, Hans Einar.
(2010)
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding.
Molecular and Cellular Biology
Vitenskapelig artikkel
2009
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
2008
-
Vågbø, Cathrine Broberg.
(2008)
Direct repair of alkylation damage in DNA and RNA by 2-oxoglutarate- and iron-dependent dioxygenases.
NTNU
Doktorgradsavhandling
-
Sundheim, Ottar;
Talstad, Vivi A;
Vågbø, Cathrine Broberg;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
AlkB demethylases flip out in different ways.
DNA Repair
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
2007
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
2006
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Vitenskapelig artikkel
2004
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
2003
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
2001
-
Chatton, Jean-Yves;
Idle, Jefrrey R.;
Vågbø, Cathrine;
Magistretti, Pierre.
(2001)
Insights into the mechanisms of ifosfamide Encephalopathy:Drug Metabolites Have Agonistic Effects on a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid(AMPA) Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons.
Journal of Pharmacology and Experimental Therapeutics
Vitenskapelig artikkel
Tidsskriftspublikasjoner
-
Schwarz, Simon D.;
Xu, Jianming;
Gunasekera, Kapila;
Schürmann, David;
Vågbø, Cathrine Broberg;
Ferrari, Elena.
(2024)
Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation.
Nature Communications
Vitenskapelig artikkel
-
Sherwood, Anna V.;
Rivera-Rangel, Lizandro R.;
Ryberg, Line A.;
Larsen, Helena S.;
Anker, Klara M.;
Costa, Rui.
(2023)
Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide.
Nature
Vitenskapelig artikkel
-
Dohnalkova, Michaela;
Krasnykov, Kyrylo;
Mendel, Mateusz;
Li, Lingyun;
Panasenko, Olesya;
Fleury-Olela, Fabienne.
(2023)
Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility.
Cell reports
Vitenskapelig artikkel
-
Hayran , Abdul Baset ;
Liabakk, Nina-Beate;
Aas, Per Arne;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Sarno, Antonio.
(2023)
RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Mendel, Mateusz;
Delaney, Kamila;
Pandey, Radha Raman;
Chen, Kuan-Ming;
Wenda, Joanna M.;
Vågbø, Cathrine Broberg.
(2021)
Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Cell
Vitenskapelig artikkel
-
Steen, Kristian Wollen;
Hagen, Lars;
Vågbø, Cathrine Broberg;
Rabe, Renana;
Iveland, Tobias Solli;
Aas, Per Arne.
(2021)
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.
Journal of Translational Medicine
Vitenskapelig artikkel
-
Maddirevula, Sateesh;
Alameer, Seham;
Ewida, Nour;
Sousa, Mirta;
Bjørås, Magnar;
Vågbø, Cathrine Broberg.
(2021)
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant.
Human Genetics
Vitenskapelig artikkel
-
Boeckemeier, L;
Kraehenbuehl, R;
Keszthelyi, A;
Gasasira, MU;
Vernon, EG;
Beardmore, R.
(2020)
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.
Science Advances
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Slupphaug, Geir.
(2020)
RNA in DNA repair.
DNA Repair
Vitenskapelig artikkel
-
Kong, Xiang Yi;
Vik, Erik Sebastian;
Nawaz, Meh Sameen;
Berges, Natalia;
Dahl, Tuva Børresdatter;
Vågbø, Cathrine.
(2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Schär, Primo;
Schuermann, David;
Schwarz, Simon D.;
Grundbacher, Eliane;
Hrovat, Alexandra M.;
Xu, Jianming.
(2020)
Inducible TDG knockout models to study epigenetic regulation.
F1000
Vitenskapelig artikkel
-
Pandey, Radha Raman;
Delfino, Elena;
Homolka, David;
Roithova, Adriana;
Chen, Kuan-Ming;
Li, Lingyun.
(2020)
The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues.
Cell reports
Vitenskapelig artikkel
-
Monies, Dorota;
Vågbø, Cathrine Broberg;
Al-Owain, Mohammad;
Alhomaidi, Suzan;
Alkuraya, Fowzan S..
(2019)
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification.
American Journal of Human Genetics
Vitenskapelig artikkel
-
Pinto, Rita;
Vågbø, Cathrine Broberg;
Jakobsson, Magnus;
Yeji, Kim;
Baltissen, Marijke P;
O'Donohue, Marie-Francoise.
(2019)
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Li, Xiang;
Zhao, Qiongyi;
Wei, Wei;
Lin, Quan;
Magnan, Christophe;
Emami, Michael R.
(2019)
The DNA modification N6-methyl-2 '-eoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.
Nature Neuroscience
Vitenskapelig artikkel
-
Prikrylova, Terezia;
Robertson, Julia;
Ferrucci, Francesca;
Konorska, Dorota Joanna;
Aanes, Håvard;
Manaf, Adeel.
(2019)
5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication.
Scientific Reports
Vitenskapelig artikkel
-
Brickner, Joshua R;
Soll, Jennifer M;
Lombardi, Patrick M;
Vågbø, Cathrine Broberg;
Mudge, Miranda C;
Oyeniran, Clement.
(2017)
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Nature
Vitenskapelig artikkel
-
Zatula, Alexey;
Dikic, Aida;
Mulder, Teska Celine;
Sharma, Animesh;
Vågbø, Cathrine Broberg;
Sousa, Mirta.
(2017)
Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.
OncoTarget
Vitenskapelig artikkel
-
Landfors, Miriam;
Johansen, Jostein;
Aronsen, Jan Magnus;
Vågbø, Cathrine Broberg;
Doré, Louis C.;
He, Chuan.
(2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Cell Discovery
Vitenskapelig artikkel
-
Ke, Shengdong;
Pandya-Jones, Amy;
Saito, Yuhki;
Fak, John J.;
Vågbø, Cathrine Broberg;
Geula, Shay.
(2017)
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.
Genes & Development
Vitenskapelig artikkel
-
Tekpli, Xavier;
Urbanucci, Alfonso;
Hashim, Adnan;
Vågbø, Cathrine Broberg;
Lyle, Robert;
Kringen, Marianne K..
(2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.
Epigenetics & Chromatin
Vitenskapelig artikkel
-
Weber, Alain R.;
Krawczyk, Claudia;
Robertson, Adam Brian;
Kusnierczyk, Anna;
Vågbø, Cathrine Broberg;
Schürmann, David.
(2016)
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.
Nature Communications
Vitenskapelig artikkel
-
Rasmussen, Erik;
Vågbø, Cathrine Broberg;
Münch, Daniel;
Krokan, Hans Einar;
Klungland, Arne;
Amdam, Gro Vang.
(2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.
Biochemistry and Biophysics Reports
Vitenskapelig artikkel
-
Ke, Shengdong;
Alemu, Endalkachew Ashenafi;
Mertens, Claudia;
Gantman, Emily Conn;
Fak, John J.;
Mele, Aldo.
(2015)
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes & Development
Vitenskapelig artikkel
-
Bjørge, Monica Dahl;
Hildrestrand, Gunn Annette;
Scheffler, Katja;
Suganthan, Rajikala;
Rolseth, Veslemøy;
Kusnierczyk, Anna.
(2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell reports
Vitenskapelig artikkel
-
Zdzalik, Daria;
Vågbø, Cathrine Broberg;
Kirpekar, F;
Davydova, Erna;
Puścian, Alicja;
Maciejewska, Agnieszka M..
(2014)
Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities.
PLOS ONE
Vitenskapelig artikkel
-
Jobert, Laure;
Skjeldam, Hanne Kim;
Dalhus, Bjørn;
Galashevskaya, Anastasia;
Vågbø, Cathrine Broberg;
Bjørås, Magnar.
(2013)
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Molecular Cell
Vitenskapelig artikkel
-
Zheng, Guanqun;
Dahl, John Arne;
Niu, Yamei;
Fedorcsak, Peter;
Huang, Chun-Min;
Li, Charles J..
(2013)
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility.
Molecular Cell
Vitenskapelig artikkel
-
Vågbø, Cathrine Broberg;
Svaasand, Eva Kathrine;
Aas, Per Arne;
Krokan, Hans Einar.
(2013)
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair
Vitenskapelig artikkel
-
Galashevskaya, Anastasia;
Sarno, Antonio;
Vågbø, Cathrine Broberg;
Aas, Per Arne;
Hagen, Lars;
Slupphaug, Geir.
(2013)
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair
Vitenskapelig artikkel
-
Meza, Trine Johansen;
Moen, Marivi;
Vågbø, Cathrine Broberg;
Krokan, Hans Einar;
Klungland, Arne;
Grini, Paul Eivind.
(2012)
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Van den Born, Erwin;
Vågbø, Cathrine Broberg;
Songe-Møller, Lene;
Leihne, VIbeke;
Lien, Guro Flor;
Leszczynska, G.
(2011)
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nature Communications
Vitenskapelig artikkel
-
Robertson, Adam Brian;
Dahl, John Arne;
Vågbø, Cathrine Broberg;
Tripathi, P;
Krokan, Hans Einar;
Klungland, Arne.
(2011)
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Leihne, VIbeke;
Kirpekar, F;
Vågbø, Cathrine Broberg;
Van den Born, Erwin;
Krokan, Hans Einar;
Grini, Paul Eivind.
(2011)
Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Pettersen, Henrik Sahlin;
Visnes, Torkild;
Vågbø, Cathrine Broberg;
Svaasand, Eva K;
Doseth, Berit;
Slupphaug, Geir.
(2011)
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Research (NAR)
Vitenskapelig artikkel
-
Songe-Møller, Lene;
Van den Born, Erwin;
Leihne, V;
Vågbø, Cathrine Broberg;
Kristoffersen, T;
Krokan, Hans Einar.
(2010)
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding.
Molecular and Cellular Biology
Vitenskapelig artikkel
-
Gilljam, Karin Margaretha;
Feyzi, Emadoldin;
Aas, Per Arne;
Sousa, Mirta;
Müller, Rebekka;
Vågbø, Cathrine Broberg.
(2009)
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Journal of Cell Biology
Vitenskapelig artikkel
-
Sundheim, Ottar;
Talstad, Vivi A;
Vågbø, Cathrine Broberg;
Slupphaug, Geir;
Krokan, Hans Einar.
(2008)
AlkB demethylases flip out in different ways.
DNA Repair
Vitenskapelig artikkel
-
Westbye, Marianne;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Talstad, Vivi A;
Kavli, Bodil Merete.
(2008)
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
Journal of Biological Chemistry
Vitenskapelig artikkel
-
Feyzi, Emadoldin;
Aas, Per Arne;
Sundheim, Ottar;
Westbye, Marianne;
Vågbø, Cathrine Broberg;
Otterlei, Marit.
(2007)
RNA Base Damage and Repair.
Current Pharmaceutical Biotechnology
Vitenskapelig oversiktsartikkel/review
-
Sundheim, Ottar;
Vågbø, Cathrine Broberg;
Bjørås, Magnar;
Mittelstedt, L.Mirta;
Talstad, Vivi;
Aas, Per Arne.
(2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
EMBO Journal
Vitenskapelig artikkel
-
Ringvoll, Jeanette;
Ringvoll, Jeanette;
Nordstrand, Line M.;
Vågbø, Cathrine Broberg;
Vagbo, CB;
Talstad, Vivi.
(2006)
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
EMBO Journal
Vitenskapelig artikkel
-
Drabløs, Finn;
Feyzi, Emadoldin;
Aas, Per Arne;
Vågbø, Cathrine Broberg;
Kavli, Bodil;
Bratlie, Marit Skyrud.
(2004)
Alkylation damage in DNA and RNA - repair mechanisms and medical significance.
DNA Repair
Vitenskapelig oversiktsartikkel/review
-
Aas, Per Arne;
Otterlei, Marit;
Falnes, P.Ø;
Vågbø, Cathrine;
Skorpen, Frank;
Akbari, Mansour.
(2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature
Vitenskapelig artikkel
-
Chatton, Jean-Yves;
Idle, Jefrrey R.;
Vågbø, Cathrine;
Magistretti, Pierre.
(2001)
Insights into the mechanisms of ifosfamide Encephalopathy:Drug Metabolites Have Agonistic Effects on a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid(AMPA) Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons.
Journal of Pharmacology and Experimental Therapeutics
Vitenskapelig artikkel
Rapport
-
Eftedal, Ingrid;
Vågbø, Cathrine Broberg;
Lund, Hedda Juni.
(2022)
Quantification of guanine-derived urinary biomarkers of oxidative stress in saturation divers by LC-MS/MS.
Norges Teknisk Naturvitenskaplige Universitet
Mastergradsoppgave
-
Vågbø, Cathrine Broberg.
(2008)
Direct repair of alkylation damage in DNA and RNA by 2-oxoglutarate- and iron-dependent dioxygenases.
NTNU
Doktorgradsavhandling
UTSTILLING
-
Emdal, Elisabeth Fritzke;
Ottestad, Anine Larsen;
Vågbø, Cathrine Broberg;
Skarpeteig, Veronica ;
Rye, Morten Beck.
(2022)
Prøv deg som en DNA-detektiv.
Forskningstorget 2022
Annen presentasjon
Formidling
2022
-
Vitenskapelig foredragEldin, Patrick; Vågbø, Cathrine Broberg; Salinas, Sara; Hagiwara, Masatoshi; Slupphaug, Geir; Briant, Laurence. (2022) Le virus Zika reprogramme l'epitranscriptome des ARNt de l'hote pour l'adapter a son biais des codons et faciliter sa traduction. Societe Francaise de Virologie XXIVème Journées Francophones de Virologie , Strasbourg 2022-04-11 - 2022-04-12
-
Vitenskapelig foredragSlupphaug, Geir; Dikic, Aida; Berg, Sigrid Karlsen; Sharma, Animesh; Hagen, Lars; Vågbø, Cathrine Broberg. (2022) Enhanced protein translation fidelity – a novel target in multiple myeloma treatment?. Proteomass Scientific Society 8th International Caparica Conference on Analytical Proteomics 2022 , Carparica, Portugal 2022-07-18 - 2022-07-21
2018
-
Vitenskapelig foredragVågbø, Cathrine Broberg. (2018) Barneuniversitetet: DNA – livets oppskrift!. Barneuniversitetet/ Kunnskapsbyen Trondheim. Barneuniversitetet: DNA – livets oppskrift! , Melhus Bibliotek 2018-11-03 - 2018-11-03
-
PosterVågbø, Cathrine Broberg; Kusnierczyk, Anna; Slupphaug, Geir. (2018) DNA and RNA modification profiling using liquid chromatography – mass spectrometry. EMBO EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice , Capri 2018-10-14 - 2018-10-17
-
PosterSlupphaug, Geir; Wollen Steen, Kristian; Rabe, Renana; Hagen, Lars; Aas, Per Arne; Sharma, Animesh. (2018) A role of ASCC3 in the quality control of methylated mRNA. EMBO EMBO Workshop - From Epigenome towards Epitranscriptome in Cell Fate Choice , Capri 2018-10-14 - 2018-10-17
2017
-
Vitenskapelig foredragVågbø, Cathrine Broberg. (2017) Mass spectrometry based analysis of modified DNA and RNA. Matriks Seminar massespektrometri , Oslo 2017-11-02 - 2017-11-02
-
Vitenskapelig foredragVågbø, Cathrine Broberg. (2017) Barneuniversitetet: DNA – livets oppskrift!. Barneuniversitetet/ Kunnskapsbyen Trondheim. Barneuniversitetet: DNA – livets oppskrift! , Trondheim Folkebibliotek 2021-04-07 - 2021-04-07
2016
-
Vitenskapelig foredragSlupphaug, Geir; Steen, Kristian Wollen; Hagen, Lars; Aas, Per Arne; Sharma, Animesh; Vågbø, Cathrine Broberg. (2016) MMS-induced modifications in mRNA and potential roles of ASCC3/ALKBH3 . The 10th International 3R (Replication, recombination and repair) Symposium, Matsue, Japan , Matsue 2016-11-13 - 2016-11-17
-
PosterSharma, Animesh; Kusnierczyk, Anna; Vågbø, Cathrine Broberg; Fonseca, Davi de Miranda; Slupphaug, Geir. (2016) PROMEC: Services within Proteomics and DNA/RNA-modomics. NTNU - Faculty of Medicine Seminar for staff at the future Faculty of Medicine and Health Sciences , Scandic Lerkendal Hotel, Trondheim 2016-11-10 - 2016-11-11
2014
-
PosterRasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne. (2014) Epigenetically modified cytosines in the honey bee genome. The Ecology of Food Perception Unconventional Model Animals in Food & Health , Oslo 2014-03-20 - 2014-03-21
2013
-
PosterRasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne. (2013) Presence of modified cytosines in the honey bee genome. Insect Nutritional Homeostasis , Bonn 2013-05-01 - 2013-05-04
2011
-
PosterPettersen, Henrik Sahlin; Visnes, Torkild; Vågbø, Cathrine Broberg; Svaasand, Eva K; Doseth, Berit; Slupphaug, Geir. (2011) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. UiO 4th EU-USA conference on DNA base damage and repair , Holmenkollen Park Hotell 2011-05-18 - 2011-05-22
2010
-
Vitenskapelig foredragMeza, Trine Johansen; Moen, Marivi N.; Vågbø, Cathrine B.; Ulleland, Marius; Krokan, Hans Einar; Arne, Klungland. (2010) The DNA dioxygenase AtALKBH2 protects Arabidopsis thaliana against methylation damage. 9th Norwegian Arabidopsis Meeting , Oslo 2010-11-11 - 2010-11-11
-
Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Müller, rebecca; Catterall, Tara C. (2010) Identification of a new and widespread and functionally important PCNA-binding motif. NTNU 6th Norwegian National Proteomics Meeting , trondheim 2010-12-09 - 2010-12-10
-
Vitenskapelig foredragVågbø, Cathrine Broberg. (2010) Biological applications of mass spectrometry in the analysis of DNA and RNA modifications. The 6th Norwegian Proteomics Conference 2010-12-09 - 2010-12-10
2009
-
Vitenskapelig foredragGilljam, Karin Margaretha; Feyzi, Emadoldin; Aas, Per Arne; Westbye, Marianne; Sousa, Mirta; Müller, Rebekka. (2009) The human AlkB homologs 1,2 and 3, localisation and tentative functions. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair 2009-06-20 - 2009-06-25
-
PosterHenrik Sahlin, Pettersen; Visnes, Torkild; Vågbø, Cathrine Broberg; Kavli, Bodil Merete; Krokan, Hans Einar. (2009) Cytotoxicity of 5-fluorouracil is mainly due to RNA effects and thymidylate synthase inhibition, not excessive DNA repair. Rikshospitalet-Radiumhospitalet og Universitetet i Oslo 2nd Erling Seeberg Symposium on DNA Repair , Ålesund og Geiranger 2009-06-20 - 2009-06-25
2008
-
Vitenskapelig foredragVågbø, Cathrine Broberg. (2008) RNA repair by AlkB proteins - fact or fiction?. Inst. for Kreftforskning og Molekylær Medisin Faglig seminar Inst. for Kreftforskning og Molekylær Medisin 2008-11-11 - 2008-11-11
-
Vitenskapelig foredragSlupphaug, Geir; Westbye, Marianne P.; Feyzi, Emadoldin; Aas, Per Arne; Vågbø, Cathrine Broberg; Talstad, Vivi. (2008) Human ABH1 is a predominantly mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. Ist Russian-EU meeting in Genomic maintenance , St. Petersburg 2008-06-24 - 2008-06-26
-
Vitenskapelig foredragVågbø, Cathrine Broberg. (2008) ALKB mediert RNA reparasjon. IKM Tirsdagsmøter ved Institutt for kreftforskning og molekylær medisin , Trondheim 2008-11-11 -
2007
-
Vitenskapelig foredragVågbø, Cathrine Broberg. (2007) Repair of RNA alkylation damage - in vivo?. Avd. for Kreftforskning og Molekylær Medisin, NTNU Fagmøte på Avd. for Kreftforskning og Molekylær Medisin , Laboratoriesenteret, NTNU 2007-09-10 - 2007-09-10
2006
-
Vitenskapelig foredragVågbø, Cathrine Broberg. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA (oral presentation). EU Integrated Project “DNA Damage Response and Rep. Mech." DNA Repair: from Molecular Mechanism to Human Disease , Noordwijkerhout 2006-04-02 - 2006-04-07
-
Vitenskapelig foredragVågbø, Cathrine Broberg. (2006) The in vivo role of mouse AlkB homologue 2 and 3 assessed through LC/MS/MS. Institutt for Kreftforskning og Molekylær Medisin, NTNU Tirsdagsseminar Institutt for Kreftforskning og Molekylær Medisin , Trondheim 2006-10-24 - 2006-10-24
-
PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Talstad, Vivi; Aas, Per Arne. (2006) Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Erling Seeberg Symposium on DNA Repair 2006-05-28 - 2006-06-02
-
PosterSousa, Mirta; Sundheim, Ottar; Vågbø, Cathrine Broberg; Talstad, Vivi; Aslaksen, Petter Broby; Slupphaug, Geir. (2006) Post-translational self-hydroxilation of an active site leucine in human ABH3 may protect against generation of damaging oxygen radicals. Erling Seeberg Symposium on DNA Repair , Bodø og Hennigsvær 2006-05-28 - 2006-06-02
-
PosterVågbø, Cathrine Broberg; Talstad, Vivi; Aas, Per Arne; Krokan, Hans Einar. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA. EU Integrated Project “DNA Damage Response and Rep. Mech." DNA Repair: from Molecular Mechanism to Human Disease , Noordwijkerhout 2006-04-02 - 2006-04-07
-
PosterVågbø, Cathrine Broberg; Talstad, Vivi; Aas, Per Arne; Krokan, Hans Einar. (2006) The in vivo role of mABH2 and mABH3 assessed through a highly sensitive and specific LC-MS/MS method for quantifying methyl lesions in DNA. Universitet i Oslo Erling Seeberg Symposium on DNA repair , Henningsvær, Lofoten 2006-05-28 - 2006-06-02
-
PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2006) Crystal structure of hABH3 DNA/RNA demethylase reveals a novel active-site leucine oxidation. Norwegian Biochemical Society (NBS) The Norwegian Biochemical Society 42. Contact Meeting , Storefjell, Storefjell Hotell 2006-01-19 - 2006-01-22
2005
-
PosterSundheim, Ottar; Vågbø, Cathrine Broberg; Bjørås, Magnar; Sousa, Mirta; Aas, Per Arne; Drabløs, Finn. (2005) Structure of the hABH3 DNA demethylase implicates an oxidized leucine residue in catalysis. 2nd ESF Functional Genomics and disease 2005-09-06 -
2004
-
Vitenskapelig foredragHagen, Lars; Vågbø, Cathrine Broberg. (2004) Mass spectrometry applications at Institute of Cancer Research and Molecular Medicine, NTNU, Trondheim. Norsk selskap for massespektrometri Møte i Norsk selskap for massespektrometri , Bergen 2004-05-10 -
2002
-
PosterVisnes, Torkild; Vågbø, Cathrine; Akbari, Mansour; Krokan, Hans Einar. (2002) To BER or not to BER - is that the question?. Norsk Biokjemisk Selskaps Vintermøte , Røros, Norge 2002-01-20 -
-
PosterVisnes, Torkild; Vågbø, Cathrine; Akbari, Mansour; Krokan, Hans Einar. (2002) The signifisance of variation of uracil DNA.glycosylase activity on uracil initiated base exicion repair. 38. Biokjemiske kontaktmøte Functinal genomics - the mosaics of life , Quality Hotel Røros 2002-01-20 -
1999
-
Populærvitenskapelig foredragVågbø, Cathrine Broberg; Brunsvik, Anders; Zahlsen, Kolbjørn; Hadidi, Hakam; Idle, Jeffrey R.. (1999) Phenotypic and excessive 3-hydroxylation of coumarin, a ubiquitous environmental contaminant. 35. Biokjemiske kontaktmøte NBS , Tromsø, 21 - 24. januar 1999
1998
-
PosterVågbø, Cathrine B.; Haidid, Hakam; Idle, Jeffrey. (1998) Thiodiglycolic acid a novel endogenous urinary metabolite in humans. Biokjemisk kontaktmøte , Lillehammer